locus-tag	class	description
M478_RS00055	COG3718	enzyme involved in inositol metabolism
M478_RS00070	COG5265	(ABC) transporter
M478_RS00845	COG1702	phosphate starvation-inducible protein PhoH
M478_RS00850	COG1702	phosphate starvation-inducible protein PhoH
M478_RS00895	COG0647	UMP catabolic process
M478_RS00985	COG0735	belongs to the Fur family
M478_RS01040	COG1129	ABC transporter
M478_RS01045	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS01050	COG0673	inositol 2-dehydrogenase activity
M478_RS01055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_RS01065	COG3718	enzyme involved in inositol metabolism
M478_RS01075	COG5265	(ABC) transporter
M478_RS01100	COG2197	response regulator
M478_RS01105	COG1278	Cold shock
M478_RS01115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M478_RS01125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M478_RS01145	COG1686	Belongs to the peptidase S11 family
M478_RS01150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M478_RS01155	COG0772	Belongs to the SEDS family
M478_RS01160	COG0768	penicillin binding
M478_RS01170	COG0799	negative regulation of ribosome biogenesis
M478_RS01180	COG1466	dna polymerase III delta subunit
M478_RS01195	COG2888	peptidyl-tyrosine sulfation
M478_RS01200	COG1126	abc transporter atp-binding protein
M478_RS01205	COG0765	amino acid transport
M478_RS01210	COG0765	amino acid transport
M478_RS01220	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M478_RS01225	COG4535	Mg2 and Co2 transporter CorC
M478_RS01235	COG1702	phosphate starvation-inducible protein PhoH
M478_RS01240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M478_RS01245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M478_RS01285	COG0367	asparagine synthase
M478_RS01290	COG0647	UMP catabolic process
M478_RS01295	COG1940	carbohydrate kinase activity
M478_RS01295	COG1846	Transcriptional regulator
M478_RS01300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M478_RS01310	COG1263	PTS System
M478_RS01310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_RS01310	COG2190	(PTS) system
M478_RS01335	COG0735	belongs to the Fur family
M478_RS01355	COG0596	Alpha beta hydrolase
M478_RS01365	COG0582	viral genome integration into host DNA
M478_RS01370	COG2963	transposase activity
M478_RS01375	COG0582	viral genome integration into host DNA
M478_RS01395	COG2113	Glycine betaine
M478_RS01400	COG4176	ABC-type proline glycine betaine transport system permease component
M478_RS01405	COG4175	Glycine betaine
M478_RS01410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M478_RS01450	COG1278	Cold shock
M478_RS01455	COG0747	negative chemotaxis
M478_RS01465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_RS01470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M478_RS01475	COG1124	(ABC) transporter
M478_RS01480	COG0831	urea catabolic process
M478_RS01505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M478_RS01515	COG4413	Urea transporter
M478_RS01520	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
M478_RS01535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M478_RS01545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M478_RS01555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M478_RS01560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M478_RS01565	COG1447	Phosphotransferase system cellobiose-specific component IIA
M478_RS01570	COG2169	Transcriptional regulator
M478_RS01570	COG1917	Cupin 2, conserved barrel domain protein
M478_RS01590	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M478_RS01595	COG0033	Phosphoglucomutase
M478_RS01615	COG0745	RESPONSE REGULATOR receiver
M478_RS01620	COG2205	protein histidine kinase activity
M478_RS01655	COG3272	Protein of unknown function (DUF1722)
M478_RS01665	COG5212	phosphodiesterase
M478_RS01670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M478_RS01680	COG1984	allophanate hydrolase subunit 2
M478_RS01735	COG0513	Belongs to the DEAD box helicase family
M478_RS01745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M478_RS01760	COG3026	antisigma factor binding
M478_RS01765	COG3086	response to oxidative stress
M478_RS01800	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M478_RS01820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_RS01825	COG1737	Transcriptional regulator
M478_RS01835	COG0560	Phosphoserine phosphatase
M478_RS01875	COG2205	protein histidine kinase activity
M478_RS01880	COG3170	Tfp pilus assembly protein FimV
M478_RS01885	COG2204	response regulator
M478_RS01890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M478_RS01890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M478_RS01895	COG0347	Belongs to the P(II) protein family
M478_RS01900	COG2188	Transcriptional regulator
M478_RS01905	COG2188	Transcriptional regulator
M478_RS01920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_RS01920	COG1017	nitric oxide dioxygenase activity
M478_RS01940	COG2814	Major facilitator Superfamily
M478_RS01945	COG3711	transcriptional antiterminator
M478_RS01950	COG3683	transport system, periplasmic component
M478_RS01955	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M478_RS01975	COG1104	cysteine desulfurase activity
M478_RS01980	COG0822	iron-sulfur transferase activity
M478_RS02000	COG0633	Ferredoxin
M478_RS02005	COG2975	iron-sulfur cluster assembly
M478_RS02025	COG3468	outer membrane autotransporter barrel domain protein
M478_RS02030	COG3468	outer membrane autotransporter barrel domain protein
M478_RS02075	COG2976	Protein conserved in bacteria
M478_RS02080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M478_RS02095	COG1645	bacterial-type flagellum-dependent swarming motility
M478_RS02105	COG0516	GMP reductase activity
M478_RS02105	COG0517	IMP dehydrogenase activity
M478_RS02160	COG3328	transposase activity
M478_RS02175	COG0351	phosphomethylpyrimidine kinase
M478_RS02195	COG0826	peptidase U32
M478_RS02200	COG3422	double-strand break repair
M478_RS02205	COG0745	RESPONSE REGULATOR receiver
M478_RS02210	COG2205	protein histidine kinase activity
M478_RS02215	COG2205	protein histidine kinase activity
M478_RS02240	COG3842	ATPase activity
M478_RS02250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M478_RS02260	COG1176	ABC-type spermidine putrescine transport system, permease component I
M478_RS02265	COG1177	transmembrane transport
M478_RS02270	COG0443	Heat shock 70 kDa protein
M478_RS02275	COG2239	Acts as a magnesium transporter
M478_RS02290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M478_RS02300	COG0581	inorganic phosphate transmembrane transporter activity
M478_RS02320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M478_RS02325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M478_RS02350	COG1393	Belongs to the ArsC family
M478_RS02355	COG4783	chaperone-mediated protein folding
M478_RS02360	COG0628	permease
M478_RS02380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M478_RS02385	COG2716	regulation of RNA biosynthetic process
M478_RS02395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M478_RS02415	COG2321	neutral zinc metallopeptidase
M478_RS02435	COG1876	peptidase activity
M478_RS02445	COG1393	Belongs to the ArsC family
M478_RS02460	COG1175	transmembrane transport
M478_RS02465	COG3842	ATPase activity
M478_RS02470	COG3119	arylsulfatase activity
M478_RS02475	COG0641	radical SAM
M478_RS02480	COG1988	membrane-bound metal-dependent
M478_RS02490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_RS02500	COG2197	response regulator
M478_RS02505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_RS02505	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_RS02510	COG3062	negative regulation of establishment of protein localization
M478_RS02520	COG3043	anaerobic respiration
M478_RS02525	COG3005	denitrification pathway
M478_RS02570	COG3111	PFAM Bacterial OB fold (BOF) protein
M478_RS02580	COG2837	iron assimilation
M478_RS02585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M478_RS02595	COG4886	Leucine-rich repeat (LRR) protein
M478_RS02605	COG2731	YhcH YjgK YiaL family protein
M478_RS02615	COG1737	Transcriptional regulator
M478_RS02625	COG4150	thiosulfate binding
M478_RS02630	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M478_RS02635	COG4208	sulfate ABC transporter
M478_RS02640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M478_RS02655	COG0745	RESPONSE REGULATOR receiver
M478_RS02660	COG5002	protein histidine kinase activity
M478_RS02660	COG3850	Histidine kinase
M478_RS02670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M478_RS02690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M478_RS02705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_RS02710	COG0745	RESPONSE REGULATOR receiver
M478_RS02715	COG2205	protein histidine kinase activity
M478_RS02740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS02750	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M478_RS02765	COG3530	Putative quorum-sensing-regulated virulence factor
M478_RS02815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M478_RS02830	COG0667	Aldo Keto reductase
M478_RS02855	COG0436	Aminotransferase
M478_RS02860	COG3038	cytochrome b561
M478_RS02890	COG3381	protein complex oligomerization
M478_RS02895	COG3302	dmso reductase anchor subunit
M478_RS02900	COG0437	4 iron, 4 sulfur cluster binding
M478_RS02905	COG0243	molybdopterin cofactor binding
M478_RS02940	COG2951	lytic endotransglycosylase activity
M478_RS03000	COG3121	Chaperone
M478_RS03005	COG3188	usher protein
M478_RS03010	COG3328	transposase activity
M478_RS03015	COG3188	usher protein
M478_RS03110	COG2824	Alkylphosphonate utilization operon protein PhnA
M478_RS03120	COG1704	LemA family
M478_RS03140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M478_RS03145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M478_RS03150	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M478_RS03160	COG1138	Cytochrome C-type biogenesis protein
M478_RS03165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M478_RS03170	COG4235	cytochrome complex assembly
M478_RS03170	COG3088	subunit of a heme lyase
M478_RS03175	COG3088	subunit of a heme lyase
M478_RS03175	COG4235	cytochrome complex assembly
M478_RS03190	COG3691	Protein conserved in bacteria
M478_RS03205	COG2062	phosphohistidine phosphatase, SixA
M478_RS03215	COG2890	protein-(glutamine-N5) methyltransferase activity
M478_RS03230	COG0730	response to heat
M478_RS03235	COG3101	peptidyl-lysine hydroxylation
M478_RS03250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_RS03255	COG1794	racemase activity, acting on amino acids and derivatives
M478_RS03270	COG0697	spore germination
M478_RS03290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M478_RS03300	COG0586	Pfam SNARE associated Golgi protein
M478_RS03310	COG0285	dihydrofolate synthase activity
M478_RS03315	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M478_RS03320	COG1286	toxin biosynthetic process
M478_RS03325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M478_RS03335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS03340	COG4215	(ABC) transporter
M478_RS03345	COG4160	amino acid transport
M478_RS03350	COG4598	ABC transporter
M478_RS03355	COG1090	epimerase
M478_RS03365	COG0622	Phosphoesterase
M478_RS03370	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
M478_RS03375	COG3037	sugar-specific permease SgaT UlaA
M478_RS03380	COG3328	transposase activity
M478_RS03395	COG1609	Transcriptional regulator
M478_RS03400	COG0857	belongs to the CobB CobQ family
M478_RS03400	COG0280	phosphate acetyltransferase
M478_RS03425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_RS03430	COG0471	metal ion transport
M478_RS03430	COG0490	domain, Protein
M478_RS03445	COG0436	Aminotransferase
M478_RS03455	COG0583	DNA-binding transcription factor activity
M478_RS03465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M478_RS03485	COG1034	ATP synthesis coupled electron transport
M478_RS03500	COG0839	Belongs to the complex I subunit 6 family
M478_RS03510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M478_RS03515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M478_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS03540	COG3265	gluconokinase activity
M478_RS03550	COG1649	PFAM Uncharacterised BCR, COG1649
M478_RS03555	COG1609	Transcriptional regulator
M478_RS03565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M478_RS03580	COG0129	dihydroxy-acid dehydratase activity
M478_RS03595	COG4575	ribosome binding
M478_RS03605	COG1169	isochorismate synthase
M478_RS03620	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M478_RS03635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M478_RS03665	COG1126	abc transporter atp-binding protein
M478_RS03670	COG0765	amino acid transport
M478_RS03675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS03705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M478_RS03725	COG1063	alcohol dehydrogenase
M478_RS03730	COG1879	ABC-type sugar transport system periplasmic component
M478_RS03735	COG1129	ABC transporter
M478_RS03740	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS03745	COG1609	Transcriptional regulator
M478_RS03750	COG0583	DNA-binding transcription factor activity
M478_RS03755	COG0473	3-isopropylmalate dehydrogenase activity
M478_RS03765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M478_RS03775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_RS03780	COG2831	hemolysin activation secretion protein
M478_RS03785	COG3210	domain, Protein
M478_RS03805	COG3210	domain, Protein
M478_RS03825	COG3210	domain, Protein
M478_RS03835	COG3842	ATPase activity
M478_RS03845	COG1609	Transcriptional regulator
M478_RS03860	COG0395	ABC-type sugar transport system, permease component
M478_RS03865	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
M478_RS03885	COG0668	transmembrane transport
M478_RS03890	COG1518	maintenance of DNA repeat elements
M478_RS03895	COG1203	CRISPR-associated helicase, Cas3
M478_RS03920	COG0667	Aldo Keto reductase
M478_RS03930	COG0477	Major facilitator Superfamily
M478_RS03940	COG0583	DNA-binding transcription factor activity
M478_RS03945	COG2771	luxR family
M478_RS03950	COG3916	Acyl-homoserine-lactone synthase
M478_RS03980	COG0628	permease
M478_RS04005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M478_RS04030	COG3328	transposase activity
M478_RS04035	COG1530	ribonuclease E activity
M478_RS04040	COG0564	pseudouridine synthase activity
M478_RS04045	COG0424	maF-like protein
M478_RS04050	COG1399	metal-binding, possibly nucleic acid-binding protein
M478_RS04055	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M478_RS04085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_RS04095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M478_RS04100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M478_RS04110	COG0470	DNA polymerase III
M478_RS04115	COG0084	hydrolase, TatD family'
M478_RS04120	COG1263	PTS System
M478_RS04120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_RS04150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M478_RS04155	COG0537	adenosine 5'-monophosphoramidase activity
M478_RS04160	COG5633	Lipoprotein
M478_RS04175	COG1472	Belongs to the glycosyl hydrolase 3 family
M478_RS04185	COG1252	NADH dehydrogenase
M478_RS04200	COG3328	transposase activity
M478_RS04205	COG3134	Outer membrane lipoprotein
M478_RS04210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M478_RS04215	COG4591	ABC-type transport system involved in lipoprotein release permease component
M478_RS04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
M478_RS04230	COG1940	carbohydrate kinase activity
M478_RS04245	COG2850	peptidyl-arginine hydroxylation
M478_RS04255	COG0745	RESPONSE REGULATOR receiver
M478_RS04265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M478_RS04285	COG1187	pseudouridine synthase activity
M478_RS04290	COG0538	isocitrate dehydrogenase activity
M478_RS04305	COG0840	transmembrane signaling receptor activity
M478_RS04310	COG0702	epimerase
M478_RS04315	COG1733	regulation of RNA biosynthetic process
M478_RS04340	COG1522	sequence-specific DNA binding
M478_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS04350	COG3321	synthase
M478_RS04350	COG0604	alcohol dehydrogenase
M478_RS04380	COG1285	pathogenesis
M478_RS04405	COG1360	Flagellar Motor Protein
M478_RS04410	COG2198	Histidine kinase
M478_RS04410	COG0643	Histidine kinase
M478_RS04415	COG0835	chemotaxis
M478_RS04420	COG2271	Major facilitator Superfamily
M478_RS04425	COG0251	oxidation-reduction process
M478_RS04435	COG2964	Protein conserved in bacteria
M478_RS04455	COG0840	transmembrane signaling receptor activity
M478_RS04460	COG0840	transmembrane signaling receptor activity
M478_RS04465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M478_RS04475	COG0745	RESPONSE REGULATOR receiver
M478_RS04480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M478_RS04490	COG3023	N-Acetylmuramoyl-L-alanine amidase
M478_RS04495	COG5295	Hep Hag repeat protein
M478_RS04500	COG5295	Hep Hag repeat protein
M478_RS04510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M478_RS04565	COG3121	Chaperone
M478_RS04585	COG3008	intermembrane lipid transfer
M478_RS04590	COG2995	paraquat-inducible protein a
M478_RS04595	COG1956	GAF domain-containing protein
M478_RS04605	COG0793	Belongs to the peptidase S41A family
M478_RS04615	COG3539	Fimbrial protein
M478_RS04620	COG3121	Chaperone
M478_RS04635	COG3121	Chaperone
M478_RS04640	COG2814	Major facilitator Superfamily
M478_RS04645	COG0823	Involved in the tonB-independent uptake of proteins
M478_RS04655	COG3023	N-Acetylmuramoyl-L-alanine amidase
M478_RS04660	COG1823	symporter activity
M478_RS04665	COG1988	membrane-bound metal-dependent
M478_RS04670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M478_RS04675	COG1653	transport
M478_RS04680	COG3842	ATPase activity
M478_RS04685	COG0395	ABC-type sugar transport system, permease component
M478_RS04690	COG1175	transmembrane transport
M478_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS04710	COG1917	Cupin 2, conserved barrel domain protein
M478_RS04715	COG3328	transposase activity
M478_RS04720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_RS04730	COG3001	Fructosamine kinase
M478_RS04740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M478_RS04745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M478_RS04750	COG1121	(ABC) transporter
M478_RS04755	COG0803	Belongs to the bacterial solute-binding protein 9 family
M478_RS04780	COG4249	Peptidase C14 caspase catalytic subunit p20
M478_RS04810	COG0072	phenylalanine-tRNA ligase activity
M478_RS04810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M478_RS04815	COG0776	regulation of translation
M478_RS04830	COG0386	Belongs to the glutathione peroxidase family
M478_RS04875	COG0791	NLP P60 protein
M478_RS04900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M478_RS04900	COG0574	Belongs to the PEP-utilizing enzyme family
M478_RS04905	COG0628	permease
M478_RS04910	COG0277	FAD linked oxidase domain protein
M478_RS04910	COG0247	lactate metabolic process
M478_RS04915	COG2050	protein possibly involved in aromatic compounds catabolism
M478_RS04925	COG0316	Belongs to the HesB IscA family
M478_RS04930	COG0719	Fe-S assembly protein
M478_RS04935	COG0396	ATPase activity
M478_RS04940	COG0719	Fe-S assembly protein
M478_RS04955	COG1388	LysM domain
M478_RS04955	COG1376	ErfK ybiS ycfS ynhG family protein
M478_RS05015	COG0307	riboflavin synthase, alpha
M478_RS05020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M478_RS05025	COG2814	Major facilitator Superfamily
M478_RS05030	COG0583	DNA-binding transcription factor activity
M478_RS05045	COG0791	NLP P60 protein
M478_RS05055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M478_RS05060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M478_RS05065	COG0346	lactoylglutathione lyase activity
M478_RS05070	COG1902	pentaerythritol trinitrate reductase activity
M478_RS05075	COG1309	transcriptional regulator
M478_RS05080	COG2194	sulfuric ester hydrolase activity
M478_RS05090	COG3133	Outer membrane lipoprotein
M478_RS05100	COG3895	Periplasmic Protein
M478_RS05120	COG0625	glutathione transferase activity
M478_RS05135	COG3104	oligopeptide transport
M478_RS05140	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M478_RS05140	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M478_RS05145	COG4172	Belongs to the ABC transporter superfamily
M478_RS05155	COG4171	peptide transport system, permease
M478_RS05160	COG4168	peptide transport system, permease
M478_RS05165	COG4166	transmembrane transport
M478_RS05185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M478_RS05190	COG1842	Phage shock protein A
M478_RS05200	COG1983	PspC domain protein
M478_RS05210	COG3106	COG3106 Predicted ATPase
M478_RS05220	COG5654	RES domain protein
M478_RS05225	COG5642	Protein of unknown function (DUF2384)
M478_RS05240	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M478_RS05245	COG4948	Mandelate Racemase Muconate Lactonizing
M478_RS05250	COG2866	Carboxypeptidase
M478_RS05255	COG4166	transmembrane transport
M478_RS05275	COG0657	acetylesterase activity
M478_RS05285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M478_RS05285	COG1013	pyruvate-flavodoxin oxidoreductase activity
M478_RS05285	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M478_RS05285	COG0674	pyruvate-flavodoxin oxidoreductase activity
M478_RS05295	COG1285	pathogenesis
M478_RS05300	COG3042	response to heat
M478_RS05305	COG3187	Heat shock protein
M478_RS05310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M478_RS05315	COG2911	Protein conserved in bacteria
M478_RS05325	COG3784	Protein of unknown function (DUF1318)
M478_RS05330	COG0246	Mannitol dehydrogenase
M478_RS05335	COG2390	Transcriptional regulator
M478_RS05345	COG1643	Atp-dependent helicase
M478_RS05360	COG3591	Belongs to the peptidase S1B family
M478_RS05415	COG1454	alcohol dehydrogenase
M478_RS05415	COG1012	belongs to the aldehyde dehydrogenase family
M478_RS05420	COG2095	MarC family integral membrane protein
M478_RS05430	COG0601	transmembrane transport
M478_RS05435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_RS05440	COG0444	Belongs to the ABC transporter superfamily
M478_RS05445	COG4608	Belongs to the ABC transporter superfamily
M478_RS05485	COG2350	Protein conserved in bacteria
M478_RS05490	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M478_RS05495	COG3328	transposase activity
M478_RS05530	COG3047	cAMP biosynthetic process
M478_RS05550	COG0134	indole-3-glycerol-phosphate synthase activity
M478_RS05550	COG0135	phosphoribosylanthranilate isomerase activity
M478_RS05560	COG0512	Glutamine amidotransferase of anthranilate synthase
M478_RS05585	COG0009	L-threonylcarbamoyladenylate synthase
M478_RS05590	COG1187	pseudouridine synthase activity
M478_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS05605	COG0616	signal peptide processing
M478_RS05625	COG0583	DNA-binding transcription factor activity
M478_RS05635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M478_RS05645	COG0671	phosphoesterase, PA-phosphatase related
M478_RS05650	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M478_RS05655	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M478_RS05670	COG0023	Translation Initiation Factor
M478_RS05690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M478_RS05695	COG2879	small protein
M478_RS05700	COG1966	Carbon starvation protein
M478_RS05710	COG2271	Major facilitator Superfamily
M478_RS05715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_RS05720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M478_RS05730	COG4659	FMN binding
M478_RS05735	COG4658	electron transport chain
M478_RS05740	COG2207	Transcriptional regulator
M478_RS05740	COG3708	Transcriptional regulator
M478_RS05770	COG1132	(ABC) transporter
M478_RS05780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_RS05785	COG2274	protein secretion by the type I secretion system
M478_RS05800	COG1879	ABC-type sugar transport system periplasmic component
M478_RS05805	COG1129	ABC transporter
M478_RS05810	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS05820	COG0673	inositol 2-dehydrogenase activity
M478_RS05825	COG0385	Bile acid
M478_RS05835	COG5339	Protein conserved in bacteria
M478_RS05845	COG0114	fumarate hydratase activity
M478_RS05860	COG0583	DNA-binding transcription factor activity
M478_RS05865	COG1940	carbohydrate kinase activity
M478_RS05870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M478_RS05875	COG0038	chloride channel
M478_RS05885	COG1609	Transcriptional regulator
M478_RS05905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M478_RS05915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M478_RS05940	COG0028	Belongs to the TPP enzyme family
M478_RS05945	COG0440	acetolactate synthase activity
M478_RS05950	COG1011	Hydrolase
M478_RS05970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M478_RS05975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M478_RS05980	COG0589	response to stress
M478_RS05985	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M478_RS05990	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M478_RS06005	COG0531	amino acid
M478_RS06015	COG0745	RESPONSE REGULATOR receiver
M478_RS06020	COG2205	protein histidine kinase activity
M478_RS06025	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M478_RS06060	COG0745	RESPONSE REGULATOR receiver
M478_RS06070	COG0788	formyltetrahydrofolate deformylase activity
M478_RS06075	COG3328	transposase activity
M478_RS06090	COG0583	DNA-binding transcription factor activity
M478_RS06095	COG0708	Exodeoxyribonuclease III
M478_RS06100	COG0494	nUDIX hydrolase
M478_RS06110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M478_RS06115	COG0709	Synthesizes selenophosphate from selenide and ATP
M478_RS06120	COG0778	Nitroreductase
M478_RS06125	COG0616	signal peptide processing
M478_RS06130	COG0252	asparaginase activity
M478_RS06135	COG1335	isochorismatase
M478_RS06140	COG3139	Protein of unknown function (DUF1315)
M478_RS06160	COG3713	MltA-interacting MipA family protein
M478_RS06165	COG2766	serine protein kinase
M478_RS06180	COG0583	DNA-binding transcription factor activity
M478_RS06190	COG2814	Major facilitator Superfamily
M478_RS06200	COG2719	SpoVR family
M478_RS06230	COG1104	cysteine desulfurase activity
M478_RS06405	COG3328	transposase activity
M478_RS06505	COG0582	viral genome integration into host DNA
M478_RS06515	COG0179	Fumarylacetoacetate (FAA) hydrolase
M478_RS06520	COG2951	lytic endotransglycosylase activity
M478_RS06535	COG2894	cell division
M478_RS06540	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M478_RS06545	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M478_RS06550	COG0318	PFAM AMP-dependent synthetase and ligase
M478_RS06565	COG1199	ATP-dependent helicase activity
M478_RS06570	COG0251	oxidation-reduction process
M478_RS06585	COG0800	Aldolase
M478_RS06590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M478_RS06595	COG1737	Transcriptional regulator
M478_RS06600	COG0469	pyruvate kinase activity
M478_RS06605	COG1560	Kdo2-lipid A biosynthetic process
M478_RS06610	COG0739	heme binding
M478_RS06615	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M478_RS06625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M478_RS06650	COG0494	nUDIX hydrolase
M478_RS06660	COG1801	Protein of unknown function DUF72
M478_RS06665	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M478_RS06685	COG3102	Protein conserved in bacteria
M478_RS06710	COG0728	peptidoglycan biosynthetic process
M478_RS06715	COG0673	inositol 2-dehydrogenase activity
M478_RS06720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M478_RS06735	COG3381	protein complex oligomerization
M478_RS06750	COG1940	carbohydrate kinase activity
M478_RS06755	COG0584	glycerophosphoryl diester phosphodiesterase
M478_RS06760	COG3842	ATPase activity
M478_RS06775	COG1176	ABC-type spermidine putrescine transport system, permease component I
M478_RS06780	COG3833	ABC-type maltose transport systems, permease component
M478_RS06805	COG0659	secondary active sulfate transmembrane transporter activity
M478_RS06825	COG2890	protein-(glutamine-N5) methyltransferase activity
M478_RS06855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M478_RS06875	COG0012	GTP binding
M478_RS06930	COG5002	protein histidine kinase activity
M478_RS06970	COG0500	methyltransferase
M478_RS06995	COG3328	transposase activity
M478_RS07040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_RS07045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M478_RS07050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M478_RS07065	COG0402	S-adenosylhomocysteine deaminase activity
M478_RS07125	COG3842	ATPase activity
M478_RS07130	COG0395	ABC-type sugar transport system, permease component
M478_RS07135	COG1175	transmembrane transport
M478_RS07145	COG0673	inositol 2-dehydrogenase activity
M478_RS07155	COG2188	Transcriptional regulator
M478_RS07295	COG2197	response regulator
M478_RS07305	COG3136	membrane protein required for alginate biosynthesis
M478_RS07325	COG1113	amino acid transport
M478_RS07345	COG2822	iron ion transport
M478_RS07350	COG0672	)-iron permease
M478_RS07365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M478_RS07365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M478_RS07365	COG0506	proline dehydrogenase activity
M478_RS07380	COG1126	abc transporter atp-binding protein
M478_RS07385	COG0765	amino acid transport
M478_RS07390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS07405	COG1191	sigma factor activity
M478_RS07440	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
M478_RS07445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M478_RS07450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M478_RS07465	COG1677	Flagellar hook-basal body complex protein FliE
M478_RS07485	COG1157	protein secretion by the type III secretion system
M478_RS07500	COG1580	Controls the rotational direction of flagella during chemotaxis
M478_RS07525	COG1987	bacterial-type flagellum assembly
M478_RS07545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_RS07550	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS07555	COG1129	ABC transporter
M478_RS07565	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS07570	COG3347	Dehydrogenase
M478_RS07570	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS07575	COG2390	Transcriptional regulator
M478_RS07585	COG1256	bacterial-type flagellum assembly
M478_RS07625	COG1558	bacterial-type flagellum-dependent cell motility
M478_RS07630	COG1815	bacterial-type flagellum-dependent cell motility
M478_RS07640	COG2747	anti-sigma28 factor FlgM
M478_RS07645	COG3418	PFAM FlgN family protein
M478_RS07670	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M478_RS07675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M478_RS07705	COG2372	response to copper ion
M478_RS07710	COG1528	Iron-storage protein
M478_RS07725	COG1770	oligopeptidase
M478_RS07740	COG3141	response to X-ray
M478_RS07745	COG0513	Belongs to the DEAD box helicase family
M478_RS07770	COG1760	l-serine dehydratase
M478_RS07775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M478_RS07780	COG2368	4-hydroxyphenylacetate
M478_RS07795	COG3971	2-oxopent-4-enoate hydratase activity
M478_RS07805	COG3384	dioxygenase
M478_RS07810	COG1012	belongs to the aldehyde dehydrogenase family
M478_RS07825	COG1846	Transcriptional regulator
M478_RS07835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS07835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_RS07840	COG3715	PTS system
M478_RS07845	COG3716	PTS system mannose fructose sorbose family IID component
M478_RS07875	COG2226	methyltransferase
M478_RS07880	COG1496	oxidoreductase activity
M478_RS07905	COG1113	amino acid transport
M478_RS07940	COG2207	Transcriptional regulator
M478_RS07950	COG1132	(ABC) transporter
M478_RS08000	COG3328	transposase activity
M478_RS08005	COG2223	nitrite transmembrane transporter activity
M478_RS08025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M478_RS08050	COG3122	Protein conserved in bacteria
M478_RS08070	COG0534	Mate efflux family protein
M478_RS08085	COG4948	Mandelate Racemase Muconate Lactonizing
M478_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS08100	COG3011	Protein conserved in bacteria
M478_RS08105	COG2271	Major facilitator Superfamily
M478_RS08110	COG1470	cell adhesion involved in biofilm formation
M478_RS08110	COG1388	LysM domain
M478_RS08115	COG3328	transposase activity
M478_RS08130	COG2925	Exonuclease
M478_RS08135	COG0531	amino acid
M478_RS08145	COG0371	Dehydrogenase
M478_RS08150	COG1129	ABC transporter
M478_RS08155	COG1129	ABC transporter
M478_RS08160	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS08170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_RS08180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M478_RS08190	COG0131	Imidazoleglycerol-phosphate dehydratase
M478_RS08190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M478_RS08210	COG0140	phosphoribosyl-ATP diphosphatase activity
M478_RS08210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M478_RS08220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M478_RS08225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M478_RS08240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M478_RS08245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_RS08250	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_RS08255	COG1120	ATPase activity
M478_RS08270	COG3486	L-lysine 6-monooxygenase (NADPH) activity
M478_RS08275	COG0076	glutamate decarboxylase activity
M478_RS08280	COG4114	ferric iron reductase
M478_RS08285	COG1253	flavin adenine dinucleotide binding
M478_RS08290	COG2982	Protein involved in outer membrane biogenesis
M478_RS08305	COG0489	protein tyrosine kinase activity
M478_RS08340	COG2814	Major facilitator Superfamily
M478_RS08350	COG1346	cytolysis
M478_RS08365	COG2949	membrane
M478_RS08370	COG4211	Belongs to the binding-protein-dependent transport system permease family
M478_RS08385	COG2311	Membrane
M478_RS08395	COG0477	Major facilitator Superfamily
M478_RS08400	COG0583	DNA-binding transcription factor activity
M478_RS08430	COG1136	(ABC) transporter
M478_RS08440	COG0303	'Molybdopterin
M478_RS08450	COG3328	transposase activity
M478_RS08460	COG0488	(ABC) transporter
M478_RS08595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M478_RS08600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M478_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS08615	COG1024	Enoyl-CoA hydratase
M478_RS08625	COG3425	synthase
M478_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS08635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_RS08640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M478_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS08685	COG2920	part of a sulfur-relay system
M478_RS08705	COG1832	CoA-binding protein
M478_RS08720	COG0210	DNA helicase
M478_RS08725	COG3304	Inner membrane component domain
M478_RS08730	COG1289	transmembrane transporter activity
M478_RS08735	COG3070	regulator of competence-specific genes
M478_RS08765	COG1067	ATP-dependent peptidase activity
M478_RS08780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_RS08795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M478_RS08810	COG3130	regulation of translation
M478_RS08820	COG3009	Protein conserved in bacteria
M478_RS08825	COG3008	intermembrane lipid transfer
M478_RS08825	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M478_RS08830	COG2995	paraquat-inducible protein a
M478_RS08835	COG0488	(ABC) transporter
M478_RS08845	COG3217	Mosc domain protein beta barrel domain protein
M478_RS08845	COG0633	Ferredoxin
M478_RS08860	COG0308	aminopeptidase N
M478_RS08880	COG1448	Aminotransferase
M478_RS08885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M478_RS08890	COG3108	Peptidase M15
M478_RS08895	COG2989	Protein conserved in bacteria
M478_RS08925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M478_RS08935	COG3173	Aminoglycoside phosphotransferase
M478_RS08950	COG1278	Cold shock
M478_RS08955	COG5383	Protein conserved in bacteria
M478_RS08970	COG0658	competence protein
M478_RS08970	COG2333	competence protein COMEC
M478_RS08985	COG0539	negative regulation of cytoplasmic translation
M478_RS09010	COG5295	Hep Hag repeat protein
M478_RS09010	COG5295	Hep Hag repeat protein
M478_RS09015	COG0252	asparaginase activity
M478_RS09020	COG1944	ATP diphosphatase activity
M478_RS09025	COG2116	formate transmembrane transporter activity
M478_RS09030	COG1882	Formate acetyltransferase
M478_RS09040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M478_RS09070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M478_RS09080	COG3107	peptidoglycan biosynthetic process
M478_RS09080	COG1674	ftsk spoiiie
M478_RS09090	COG0492	ferredoxin-NADP+ reductase activity
M478_RS09105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M478_RS09115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M478_RS09125	COG0542	response to heat
M478_RS09135	COG1278	Cold shock
M478_RS09145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_RS09150	COG2990	Protein conserved in bacteria
M478_RS09155	COG3593	DNA synthesis involved in DNA repair
M478_RS09160	COG2431	L-lysine efflux transmembrane transporter activity
M478_RS09170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_RS09175	COG0028	Belongs to the TPP enzyme family
M478_RS09180	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M478_RS09185	COG0702	epimerase
M478_RS09190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_RS09200	COG1605	Chorismate mutase
M478_RS09205	COG1126	abc transporter atp-binding protein
M478_RS09210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS09215	COG4215	(ABC) transporter
M478_RS09220	COG4160	amino acid transport
M478_RS09240	COG1120	ATPase activity
M478_RS09270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS09285	COG1177	transmembrane transport
M478_RS09290	COG1176	ABC-type spermidine putrescine transport system, permease component I
M478_RS09295	COG3842	ATPase activity
M478_RS09300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M478_RS09335	COG0671	phosphoesterase, PA-phosphatase related
M478_RS09345	COG1349	DNA-binding transcription factor activity
M478_RS09350	COG0814	amino acid
M478_RS09360	COG1686	Belongs to the peptidase S11 family
M478_RS09365	COG2011	ABC-type metal ion transport system permease component
M478_RS09390	COG0625	glutathione transferase activity
M478_RS09395	COG4771	TonB-dependent receptor
M478_RS09405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_RS09415	COG0833	amino acid
M478_RS09420	COG0583	DNA-binding transcription factor activity
M478_RS09425	COG2855	membrane
M478_RS09435	COG3188	usher protein
M478_RS09440	COG3121	Chaperone
M478_RS09455	COG3710	Transcriptional regulator
M478_RS09460	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M478_RS09460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_RS09460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_RS09465	COG1105	Belongs to the carbohydrate kinase PfkB family
M478_RS09475	COG0494	nUDIX hydrolase
M478_RS09485	COG1129	ABC transporter
M478_RS09520	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS09545	COG0246	Mannitol dehydrogenase
M478_RS09550	COG2186	Transcriptional regulator
M478_RS09560	COG0523	cobalamin synthesis protein
M478_RS09565	COG0671	phosphoesterase, PA-phosphatase related
M478_RS09570	COG0791	NLP P60 protein
M478_RS09575	COG2200	EAL domain
M478_RS09580	COG4166	transmembrane transport
M478_RS09585	COG4174	ABC transporter (Permease)
M478_RS09590	COG4239	(ABC) transporter, permease
M478_RS09595	COG4172	Belongs to the ABC transporter superfamily
M478_RS09605	COG2814	Major facilitator Superfamily
M478_RS09610	COG1187	pseudouridine synthase activity
M478_RS09615	COG1061	Type III restriction enzyme res subunit
M478_RS09640	COG3082	Protein of unknown function (DUF1414)
M478_RS09645	COG3083	sulfuric ester hydrolase activity
M478_RS09655	COG3157	Type VI secretion system effector, Hcp
M478_RS09670	COG2723	6-phospho-beta-galactosidase activity
M478_RS09675	COG1737	Transcriptional regulator
M478_RS09695	COG3299	homolog of phage Mu protein gp47
M478_RS09735	COG4386	tail sheath protein
M478_RS09755	COG3622	Belongs to the hyi family
M478_RS09760	COG1349	DNA-binding transcription factor activity
M478_RS09770	COG3395	kinase activity
M478_RS09815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M478_RS09840	COG2223	nitrite transmembrane transporter activity
M478_RS09845	COG2198	Histidine kinase
M478_RS09845	COG0642	Histidine kinase
M478_RS09850	COG0642	Histidine kinase
M478_RS09850	COG2198	Histidine kinase
M478_RS09860	COG0784	Response regulator, receiver
M478_RS09860	COG2205	protein histidine kinase activity
M478_RS09890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_RS09905	COG0814	amino acid
M478_RS09930	COG0697	spore germination
M478_RS09940	COG1982	Orn Lys Arg decarboxylase major
M478_RS09945	COG0531	amino acid
M478_RS09950	COG1174	glycine betaine transport
M478_RS09955	COG1125	glycine betaine transport
M478_RS09960	COG1174	glycine betaine transport
M478_RS09965	COG1732	Glycine betaine
M478_RS09970	COG1732	Glycine betaine
M478_RS09975	COG2897	thiosulfate sulfurtransferase activity
M478_RS09995	COG1122	ATPase activity
M478_RS10015	COG4807	Protein conserved in bacteria
M478_RS10030	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M478_RS10040	COG2261	transglycosylase associated protein
M478_RS10060	COG0277	FAD linked oxidase domain protein
M478_RS10065	COG1686	Belongs to the peptidase S11 family
M478_RS10075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M478_RS10095	COG0670	Belongs to the BI1 family
M478_RS10100	COG0314	molybdopterin synthase activity
M478_RS10105	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M478_RS10115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M478_RS10125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M478_RS10130	COG4628	conserved protein (DUF2132)
M478_RS10140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M478_RS10150	COG2226	methyltransferase
M478_RS10175	COG0561	phosphatase activity
M478_RS10185	COG4149	molybdate abc transporter
M478_RS10190	COG0725	ABC transporter, periplasmic molybdate-binding protein
M478_RS10200	COG3585	molybdate ion transport
M478_RS10200	COG2005	Transcriptional regulator
M478_RS10205	COG1119	ATPase activity
M478_RS10220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M478_RS10225	COG1085	galactose-1-phosphate uridylyltransferase
M478_RS10240	COG2017	converts alpha-aldose to the beta-anomer
M478_RS10255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M478_RS10260	COG1230	cation diffusion facilitator family transporter
M478_RS10290	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M478_RS10295	COG2885	chlorophyll binding
M478_RS10305	COG3064	Membrane
M478_RS10305	COG3064	Membrane
M478_RS10310	COG0848	biopolymer transport protein
M478_RS10315	COG0811	peptide transport
M478_RS10320	COG0824	Thioesterase
M478_RS10325	COG3790	cyd operon protein YbgE
M478_RS10330	COG4890	Cyd operon protein YbgT
M478_RS10335	COG1294	oxidase, subunit
M478_RS10340	COG1271	oxidase subunit
M478_RS10345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M478_RS10355	COG0508	dehydrogenase complex catalyzes the overall conversion of
M478_RS10360	COG0567	Dehydrogenase, E1 component
M478_RS10370	COG1053	succinate dehydrogenase
M478_RS10375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M478_RS10380	COG2009	succinate dehydrogenase
M478_RS10395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M478_RS10400	COG0497	DNA recombination
M478_RS10405	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M478_RS10415	COG2867	negative regulation of translational initiation
M478_RS10435	COG0582	viral genome integration into host DNA
M478_RS10495	COG3657	addiction module killer protein
M478_RS10525	COG1953	Uracil, thiamine, allantoin
M478_RS10545	COG2226	methyltransferase
M478_RS10550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M478_RS10555	COG1388	LysM domain
M478_RS10555	COG0741	lytic transglycosylase activity
M478_RS10570	COG0656	L-ascorbic acid biosynthetic process
M478_RS10600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M478_RS10610	COG2011	ABC-type metal ion transport system permease component
M478_RS10615	COG1464	Belongs to the NlpA lipoprotein family
M478_RS10625	COG1720	tRNA m6t6A37 methyltransferase activity
M478_RS10635	COG3015	lipoprotein NlpE involved in copper resistance
M478_RS10645	COG4681	YaeQ
M478_RS10655	COG4568	rho-dependent transcription termination
M478_RS10665	COG0037	tRNA processing
M478_RS10670	COG0346	lactoylglutathione lyase activity
M478_RS10680	COG0587	DNA-directed DNA polymerase activity
M478_RS10705	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M478_RS10720	COG0750	zinc metalloprotease
M478_RS10725	COG0575	Belongs to the CDS family
M478_RS10785	COG0564	pseudouridine synthase activity
M478_RS10790	COG3098	single-species biofilm formation
M478_RS10810	COG1611	Belongs to the LOG family
M478_RS10835	COG2363	Small membrane protein
M478_RS10840	COG0583	DNA-binding transcription factor activity
M478_RS10845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M478_RS10850	COG2166	iron-sulfur cluster assembly
M478_RS10855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M478_RS10860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M478_RS10875	COG0860	N-Acetylmuramoyl-L-alanine amidase
M478_RS10885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M478_RS10890	COG1074	ATP-dependent DNA helicase activity
M478_RS10900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M478_RS10965	COG0667	Aldo Keto reductase
M478_RS10995	COG1609	Transcriptional regulator
M478_RS11005	COG0583	DNA-binding transcription factor activity
M478_RS11010	COG2814	Major facilitator Superfamily
M478_RS11015	COG0583	DNA-binding transcription factor activity
M478_RS11030	COG0840	transmembrane signaling receptor activity
M478_RS11100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M478_RS11120	COG0288	reversible hydration of carbon dioxide
M478_RS11165	COG4771	TonB-dependent receptor
M478_RS11170	COG2195	Cleaves the N-terminal amino acid of tripeptides
M478_RS11175	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M478_RS11215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_RS11225	COG5001	Diguanylate cyclase
M478_RS11230	COG2801	Transposase and inactivated derivatives
M478_RS11240	COG2211	Major facilitator Superfamily
M478_RS11290	COG2771	luxR family
M478_RS11295	COG3916	Acyl-homoserine-lactone synthase
M478_RS11430	COG1982	Orn Lys Arg decarboxylase major
M478_RS11435	COG1879	ABC-type sugar transport system periplasmic component
M478_RS11440	COG1129	ABC transporter
M478_RS11445	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS11450	COG4774	siderophore transport
M478_RS11470	COG1194	a g-specific adenine glycosylase
M478_RS11480	COG3171	Protein conserved in bacteria
M478_RS11500	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M478_RS11500	COG1073	alpha beta
M478_RS11500	COG3064	Membrane
M478_RS11505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M478_RS11510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M478_RS11520	COG0762	integral membrane protein
M478_RS11525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M478_RS11530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M478_RS11535	COG2805	Type II/IV secretion system protein
M478_RS11545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M478_RS11560	COG0189	ligase activity
M478_RS11565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M478_RS11570	COG2356	endonuclease I
M478_RS11585	COG1166	arginine decarboxylase activity
M478_RS11595	COG0501	Belongs to the peptidase M48B family
M478_RS11600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M478_RS11620	COG0191	fructose-bisphosphate aldolase activity
M478_RS11655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M478_RS11660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M478_RS11675	COG0006	proline dipeptidase activity
M478_RS11680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M478_RS11685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M478_RS11715	COG5295	Hep Hag repeat protein
M478_RS11725	COG1272	protein, Hemolysin III
M478_RS11770	COG0745	RESPONSE REGULATOR receiver
M478_RS11775	COG2205	protein histidine kinase activity
M478_RS11780	COG4452	Inner membrane protein CreD
M478_RS11785	COG0716	FMN binding
M478_RS11790	COG4974	Belongs to the 'phage' integrase family
M478_RS11795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M478_RS11800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M478_RS11820	COG0582	viral genome integration into host DNA
M478_RS11850	COG2944	sequence-specific DNA binding
M478_RS11945	COG1695	Transcriptional regulator
M478_RS11950	COG0791	NLP P60 protein
M478_RS11960	COG1879	ABC-type sugar transport system periplasmic component
M478_RS11965	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS11970	COG1129	ABC transporter
M478_RS11980	COG2182	Extracellular solute-binding protein
M478_RS11985	COG1175	transmembrane transport
M478_RS11990	COG3833	ABC-type maltose transport systems, permease component
M478_RS11995	COG3867	Arabinogalactan endo-beta-1,4-galactanase
M478_RS12000	COG1874	Beta-galactosidase
M478_RS12005	COG1263	PTS System
M478_RS12005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_RS12025	COG2271	Major facilitator Superfamily
M478_RS12055	COG3119	arylsulfatase activity
M478_RS12060	COG0641	radical SAM
M478_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS12080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS12085	COG3716	PTS system mannose fructose sorbose family IID component
M478_RS12090	COG3715	PTS system
M478_RS12095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_RS12100	COG2222	sugar isomerase
M478_RS12110	COG1349	DNA-binding transcription factor activity
M478_RS12115	COG3119	arylsulfatase activity
M478_RS12140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M478_RS12140	COG2226	methyltransferase
M478_RS12140	COG3433	isochorismatase activity
M478_RS12150	COG3433	isochorismatase activity
M478_RS12150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M478_RS12150	COG2226	methyltransferase
M478_RS12175	COG1132	(ABC) transporter
M478_RS12175	COG2375	cellular response to nickel ion
M478_RS12180	COG1132	(ABC) transporter
M478_RS12195	COG2610	gluconate transmembrane transporter activity
M478_RS12225	COG3501	Rhs element vgr protein
M478_RS12250	COG0471	metal ion transport
M478_RS12265	COG2801	Transposase and inactivated derivatives
M478_RS12280	COG3710	Transcriptional regulator
M478_RS12300	COG1256	bacterial-type flagellum assembly
M478_RS12310	COG1706	bacterial-type flagellum-dependent cell motility
M478_RS12320	COG4786	Flagellar basal body rod
M478_RS12325	COG4787	bacterial-type flagellum-dependent cell motility
M478_RS12330	COG1749	Flagellar hook protein flgE
M478_RS12335	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M478_RS12340	COG1558	bacterial-type flagellum-dependent cell motility
M478_RS12345	COG1815	bacterial-type flagellum-dependent cell motility
M478_RS12350	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M478_RS12390	COG1677	Flagellar hook-basal body complex protein FliE
M478_RS12415	COG1987	bacterial-type flagellum assembly
M478_RS12420	COG1684	flagellar biosynthetic protein fliR
M478_RS12425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M478_RS12445	COG4592	Periplasmic binding protein
M478_RS12480	COG4964	Belongs to the GSP D family
M478_RS12485	COG4964	Belongs to the GSP D family
M478_RS12535	COG0848	biopolymer transport protein
M478_RS12540	COG0811	peptide transport
M478_RS12545	COG0626	cystathionine gamma-synthase activity
M478_RS12550	COG0586	Pfam SNARE associated Golgi protein
M478_RS12555	COG2207	Transcriptional regulator
M478_RS12560	COG1979	alcohol dehydrogenase
M478_RS12570	COG0656	L-ascorbic acid biosynthetic process
M478_RS12580	COG2132	Multicopper oxidase
M478_RS12590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M478_RS12600	COG2249	NAD(P)H dehydrogenase (quinone) activity
M478_RS12605	COG0583	DNA-binding transcription factor activity
M478_RS12615	COG3150	esterase
M478_RS12620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M478_RS12625	COG3151	Protein conserved in bacteria
M478_RS12630	COG0494	nUDIX hydrolase
M478_RS12635	COG1538	Outer membrane efflux protein
M478_RS12650	COG0754	glutathionylspermidine amidase activity
M478_RS12655	COG3384	dioxygenase
M478_RS12675	COG0531	amino acid
M478_RS12690	COG3025	triphosphatase activity
M478_RS12695	COG4991	sh3 domain protein
M478_RS12710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M478_RS12725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M478_RS12730	COG0358	DNA primase activity
M478_RS12815	COG0251	oxidation-reduction process
M478_RS12835	COG0436	Aminotransferase
M478_RS12860	COG1289	transmembrane transporter activity
M478_RS12880	COG0395	ABC-type sugar transport system, permease component
M478_RS12890	COG2182	Extracellular solute-binding protein
M478_RS12895	COG1609	Transcriptional regulator
M478_RS12900	COG3459	Glycosyltransferase 36 associated
M478_RS12905	COG3842	ATPase activity
M478_RS12925	COG3210	domain, Protein
M478_RS12950	COG3210	domain, Protein
M478_RS12955	COG2831	hemolysin activation secretion protein
M478_RS12960	COG4245	von Willebrand factor, type A
M478_RS12975	COG4245	von Willebrand factor, type A
M478_RS12995	COG3247	response to pH
M478_RS13000	COG1902	pentaerythritol trinitrate reductase activity
M478_RS13000	COG0446	pyridine nucleotide-disulphide oxidoreductase
M478_RS13015	COG1451	nucleotide metabolic process
M478_RS13020	COG0673	inositol 2-dehydrogenase activity
M478_RS13045	COG2721	sulfolactate sulfo-lyase activity
M478_RS13065	COG2271	Major facilitator Superfamily
M478_RS13080	COG0586	Pfam SNARE associated Golgi protein
M478_RS13100	COG4575	ribosome binding
M478_RS13105	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
M478_RS13115	COG2259	Doxx family
M478_RS13120	COG0435	Glutathione S-transferase
M478_RS13135	COG0494	nUDIX hydrolase
M478_RS13160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M478_RS13165	COG0849	cell division
M478_RS13170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M478_RS13190	COG0772	Belongs to the SEDS family
M478_RS13205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M478_RS13210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M478_RS13215	COG0768	penicillin binding
M478_RS13220	COG3116	cell division
M478_RS13240	COG1609	Transcriptional regulator
M478_RS13260	COG0028	Belongs to the TPP enzyme family
M478_RS13270	COG1022	Amp-dependent synthetase and ligase
M478_RS13315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M478_RS13320	COG1280	lysine exporter protein (LysE YggA)
M478_RS13325	COG2966	Psort location CytoplasmicMembrane, score
M478_RS13335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M478_RS13385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M478_RS13390	COG0564	pseudouridine synthase activity
M478_RS13475	COG2885	chlorophyll binding
M478_RS13475	COG3047	cAMP biosynthetic process
M478_RS13495	COG0417	DNA replication proofreading
M478_RS13500	COG0586	Pfam SNARE associated Golgi protein
M478_RS13505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M478_RS13510	COG1178	ABC-type Fe3 transport system permease component
M478_RS13515	COG4143	(ABC) transporter
M478_RS13535	COG2814	Major facilitator Superfamily
M478_RS13550	COG0473	3-isopropylmalate dehydrogenase activity
M478_RS13580	COG1047	Peptidyl-prolyl cis-trans
M478_RS13595	COG0196	riboflavin kinase activity
M478_RS13610	COG0583	DNA-binding transcription factor activity
M478_RS13630	COG1584	GPR1 FUN34 yaaH family protein
M478_RS13645	COG0521	Mo-molybdopterin cofactor biosynthetic process
M478_RS13675	COG0745	RESPONSE REGULATOR receiver
M478_RS13680	COG3045	CreA protein
M478_RS13685	COG2207	Transcriptional regulator
M478_RS13685	COG3708	Transcriptional regulator
M478_RS13700	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M478_RS13705	COG0741	lytic transglycosylase activity
M478_RS13720	COG2199	diguanylate cyclase activity
M478_RS13725	COG2885	chlorophyll binding
M478_RS13750	COG0560	Phosphoserine phosphatase
M478_RS13755	COG3726	membrane protein affecting hemolysin expression
M478_RS13785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M478_RS13790	COG0084	hydrolase, TatD family'
M478_RS13795	COG4667	esterase of the alpha-beta hydrolase superfamily
M478_RS13805	COG2823	Periplasmic or secreted lipoprotein
M478_RS13815	COG0456	acetyltransferase
M478_RS13820	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
M478_RS13865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_RS13870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_RS13890	COG0859	PFAM glycosyl transferase family 9
M478_RS13895	COG1070	Carbohydrate kinase
M478_RS13945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS13945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS13945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M478_RS13950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_RS13955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_RS13960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M478_RS13965	COG2207	Transcriptional regulator
M478_RS13975	COG4269	membrane
M478_RS14030	COG2963	transposase activity
M478_RS14045	COG1401	restriction endodeoxyribonuclease activity
M478_RS14075	COG1011	Hydrolase
M478_RS14090	COG0174	glutamine synthetase
M478_RS14095	COG3852	Histidine kinase
M478_RS14105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M478_RS14140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M478_RS14140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M478_RS14145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M478_RS14150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M478_RS14155	COG3084	Protein conserved in bacteria
M478_RS14165	COG1763	Mo-molybdopterin cofactor biosynthetic process
M478_RS14170	COG3328	transposase activity
M478_RS14215	COG0151	Belongs to the GarS family
M478_RS14235	COG1515	deoxyribonuclease V activity
M478_RS14275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M478_RS14340	COG0250	Participates in transcription elongation, termination and antitermination
M478_RS14400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M478_RS14425	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M478_RS14430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M478_RS14435	COG1739	Uncharacterized protein family UPF0029
M478_RS14445	COG1739	Uncharacterized protein family UPF0029
M478_RS14470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M478_RS14505	COG0805	protein transport
M478_RS14515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M478_RS14535	COG1322	Protein conserved in bacteria
M478_RS14540	COG0586	Pfam SNARE associated Golgi protein
M478_RS14545	COG1966	Carbon starvation protein
M478_RS14560	COG0412	Dienelactone hydrolase
M478_RS14570	COG0583	DNA-binding transcription factor activity
M478_RS14575	COG0697	spore germination
M478_RS14580	COG0679	Auxin Efflux Carrier
M478_RS14585	COG0584	glycerophosphoryl diester phosphodiesterase
M478_RS14645	COG0410	ABC transporter
M478_RS14655	COG4177	L-phenylalanine transmembrane transporter activity
M478_RS14665	COG0683	leucine binding
M478_RS14690	COG2177	Part of the ABC transporter FtsEX involved in
M478_RS14695	COG2884	Cell division ATP-binding protein ftsE
M478_RS14700	COG0552	protein localization to endoplasmic reticulum
M478_RS14700	COG0552	protein localization to endoplasmic reticulum
M478_RS14710	COG0742	ribosomal rna small subunit methyltransferase
M478_RS14715	COG3776	membrane
M478_RS14730	COG3714	YhhN family
M478_RS14745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M478_RS14755	COG0247	lactate metabolic process
M478_RS14765	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M478_RS14775	COG0584	glycerophosphoryl diester phosphodiesterase
M478_RS14785	COG0561	phosphatase activity
M478_RS14790	COG2267	carboxylic ester hydrolase activity
M478_RS14795	COG1280	lysine exporter protein (LysE YggA)
M478_RS14800	COG1280	lysine exporter protein (LysE YggA)
M478_RS14805	COG0514	ATP-dependent DNA helicase (RecQ)
M478_RS14810	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M478_RS14815	COG2050	protein possibly involved in aromatic compounds catabolism
M478_RS14830	COG5564	TIM-barrel signal transduction protein
M478_RS14835	COG5441	Belongs to the UPF0261 family
M478_RS14845	COG0210	DNA helicase
M478_RS14850	COG1011	Hydrolase
M478_RS14855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M478_RS14860	COG3159	Protein conserved in bacteria
M478_RS14880	COG3072	Adenylate cyclase
M478_RS14895	COG1587	Uroporphyrinogen-III synthase
M478_RS14900	COG2959	enzyme of heme biosynthesis
M478_RS14905	COG3071	HemY protein
M478_RS14935	COG1113	amino acid transport
M478_RS14955	COG2244	polysaccharide biosynthetic process
M478_RS14960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M478_RS14965	COG0456	acetyltransferase
M478_RS14970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M478_RS14975	COG1088	dTDP-glucose 4,6-dehydratase activity
M478_RS14980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M478_RS14985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M478_RS14990	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M478_RS14995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M478_RS15000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M478_RS15005	COG3118	belongs to the thioredoxin family
M478_RS15035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M478_RS15045	COG3328	transposase activity
M478_RS15060	COG3121	Chaperone
M478_RS15075	COG3121	Chaperone
M478_RS15115	COG0583	DNA-binding transcription factor activity
M478_RS15155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M478_RS15160	COG3978	acetolactate synthase activity
M478_RS15175	COG3085	chromosome segregation
M478_RS15185	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS15190	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS15195	COG1129	ABC transporter
M478_RS15200	COG1879	ABC-type sugar transport system periplasmic component
M478_RS15280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M478_RS15280	COG0678	peroxiredoxin activity
M478_RS15285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M478_RS15310	COG1629	transport
M478_RS15330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M478_RS15350	COG2801	Transposase and inactivated derivatives
M478_RS15360	COG0527	aspartate kinase activity
M478_RS15360	COG0460	homoserine dehydrogenase
M478_RS15380	COG4682	membrane
M478_RS15390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M478_RS15405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M478_RS15420	COG1575	Belongs to the MenA family. Type 1 subfamily
M478_RS15490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M478_RS15495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M478_RS15500	COG1494	fructose-1,6-bisphosphatase
M478_RS15510	COG3152	Membrane
M478_RS15525	COG0583	DNA-binding transcription factor activity
M478_RS15530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M478_RS15535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M478_RS15540	COG0471	metal ion transport
M478_RS15550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M478_RS15570	COG3678	ATP-independent chaperone mediated protein folding
M478_RS15575	COG0745	RESPONSE REGULATOR receiver
M478_RS15580	COG2205	protein histidine kinase activity
M478_RS15585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M478_RS15585	COG2169	Transcriptional regulator
M478_RS15590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M478_RS15595	COG1045	serine acetyltransferase
M478_RS15615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M478_RS15620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M478_RS15630	COG4942	peptidase
M478_RS15645	COG0156	8-amino-7-oxononanoate synthase activity
M478_RS15655	COG0859	PFAM glycosyl transferase family 9
M478_RS15660	COG0859	PFAM glycosyl transferase family 9
M478_RS15665	COG1519	Transferase
M478_RS15700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M478_RS15725	COG1561	YicC-like family, N-terminal region
M478_RS15730	COG2860	membrane
M478_RS15750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M478_RS15755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M478_RS15760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M478_RS15765	COG0786	glutamate:sodium symporter activity
M478_RS15770	COG2233	PERMEase
M478_RS15775	COG2982	Protein involved in outer membrane biogenesis
M478_RS15780	COG0456	acetyltransferase
M478_RS15795	COG0435	Glutathione S-transferase
M478_RS15800	COG0583	DNA-binding transcription factor activity
M478_RS15805	COG1741	Belongs to the pirin family
M478_RS15810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M478_RS15830	COG2823	Periplasmic or secreted lipoprotein
M478_RS15840	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M478_RS15850	COG0784	Response regulator, receiver
M478_RS15850	COG2198	Histidine kinase
M478_RS15850	COG5002	protein histidine kinase activity
M478_RS15860	COG1242	4 iron, 4 sulfur cluster binding
M478_RS15865	COG0067	glutamate synthase
M478_RS15865	COG0070	glutamate synthase
M478_RS15865	COG0069	glutamate synthase activity
M478_RS15870	COG0493	'glutamate synthase
M478_RS15880	COG2969	positive regulation of protein catabolic process
M478_RS15885	COG0625	glutathione transferase activity
M478_RS15905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M478_RS15910	COG3105	Protein conserved in bacteria
M478_RS15915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M478_RS15925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M478_RS15935	COG5007	Belongs to the BolA IbaG family
M478_RS15940	COG3113	response to antibiotic
M478_RS15945	COG2854	intermembrane phospholipid transfer
M478_RS15950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M478_RS15955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M478_RS15960	COG1127	ABC transporter
M478_RS15965	COG0530	calcium, potassium:sodium antiporter activity
M478_RS15970	COG0517	IMP dehydrogenase activity
M478_RS15970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M478_RS15975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M478_RS15980	COG3117	lipopolysaccharide transmembrane transporter activity
M478_RS15985	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M478_RS15990	COG1137	ATPase activity
M478_RS15995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M478_RS16015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS16040	COG1609	Transcriptional regulator
M478_RS16045	COG1263	PTS System
M478_RS16045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M478_RS16050	COG0366	Alpha amylase catalytic
M478_RS16055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M478_RS16060	COG3783	Cytochrome b(562)
M478_RS16070	COG0312	modulator of DNA gyrase
M478_RS16080	COG2732	(Barnase) inhibitor
M478_RS16095	COG1012	belongs to the aldehyde dehydrogenase family
M478_RS16115	COG0583	DNA-binding transcription factor activity
M478_RS16165	COG0312	modulator of DNA gyrase
M478_RS16170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M478_RS16175	COG3164	Protein of unknown function
M478_RS16180	COG1530	ribonuclease E activity
M478_RS16185	COG0424	maF-like protein
M478_RS16190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M478_RS16195	COG1792	Involved in formation and maintenance of cell shape
M478_RS16200	COG1077	Cell shape determining protein MreB Mrl
M478_RS16205	COG2200	EAL domain
M478_RS16205	COG2199	diguanylate cyclase activity
M478_RS16210	COG0604	alcohol dehydrogenase
M478_RS16215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M478_RS16230	COG0511	ligase activity, forming carbon-carbon bonds
M478_RS16235	COG0439	Biotin carboxylase
M478_RS16240	COG3924	membrane
M478_RS16245	COG4145	pantothenate transmembrane transporter activity
M478_RS16255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M478_RS16260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M478_RS16280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M478_RS16290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M478_RS16295	COG3133	Outer membrane lipoprotein
M478_RS16305	COG1278	Cold shock
M478_RS16310	COG1278	Cold shock
M478_RS16335	COG0625	glutathione transferase activity
M478_RS16345	COG1069	ribulokinase activity
M478_RS16355	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS16360	COG1129	ABC transporter
M478_RS16370	COG1560	Kdo2-lipid A biosynthetic process
M478_RS16380	COG0025	NhaP-type Na H and K H
M478_RS16385	COG2252	PERMEase
M478_RS16390	COG3077	Addiction module antitoxin, RelB DinJ family
M478_RS16400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M478_RS16410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M478_RS16415	COG0431	NADPH-dependent FMN reductase
M478_RS16420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M478_RS16425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_RS16430	COG1869	D-ribose catabolic process
M478_RS16435	COG2207	Transcriptional regulator
M478_RS16435	COG1917	Cupin 2, conserved barrel domain protein
M478_RS16440	COG0673	inositol 2-dehydrogenase activity
M478_RS16455	COG3209	COG3209 Rhs family protein
M478_RS16465	COG3501	Rhs element vgr protein
M478_RS16505	COG3501	Rhs element vgr protein
M478_RS16580	COG2801	Transposase and inactivated derivatives
M478_RS16655	COG1175	transmembrane transport
M478_RS16660	COG3833	ABC-type maltose transport systems, permease component
M478_RS16675	COG0527	aspartate kinase activity
M478_RS16695	COG1414	Transcriptional regulator
M478_RS16700	COG1414	Transcriptional regulator
M478_RS16710	COG2224	Isocitrate lyase
M478_RS16715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M478_RS16760	COG2186	Transcriptional regulator
M478_RS16765	COG0477	Major facilitator Superfamily
M478_RS16775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_RS16805	COG1522	sequence-specific DNA binding
M478_RS16810	COG0716	FMN binding
M478_RS16825	COG3312	ion transport
M478_RS16880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M478_RS16885	COG0573	inorganic phosphate transmembrane transporter activity
M478_RS16890	COG0581	inorganic phosphate transmembrane transporter activity
M478_RS16900	COG0704	Plays a role in the regulation of phosphate uptake
M478_RS16910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS16915	COG0765	amino acid transport
M478_RS16920	COG0765	amino acid transport
M478_RS16925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_RS16930	COG2252	PERMEase
M478_RS16955	COG0706	membrane insertase activity
M478_RS16965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M478_RS16975	COG0592	DNA-directed DNA polymerase activity
M478_RS16990	COG0187	DNA topoisomerase II activity
M478_RS16995	COG0561	phosphatase activity
M478_RS17000	COG2801	Transposase and inactivated derivatives
M478_RS17010	COG2423	ornithine cyclodeaminase activity
M478_RS17015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M478_RS17020	COG0823	Involved in the tonB-independent uptake of proteins
M478_RS17025	COG0823	Involved in the tonB-independent uptake of proteins
M478_RS17030	COG5645	(Lipo)protein
M478_RS17050	COG3977	Valine--pyruvate aminotransferase
M478_RS17060	COG0366	Alpha amylase catalytic
M478_RS17075	COG2885	chlorophyll binding
M478_RS17085	COG2818	Glycosylase
M478_RS17105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M478_RS17105	COG2213	PTS system mannitol-specific
M478_RS17115	COG3722	fumarate hydratase activity
M478_RS17140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M478_RS17150	COG3383	formate dehydrogenase (NAD+) activity
M478_RS17150	COG0243	molybdopterin cofactor binding
M478_RS17155	COG0243	molybdopterin cofactor binding
M478_RS17155	COG3383	formate dehydrogenase (NAD+) activity
M478_RS17160	COG0437	4 iron, 4 sulfur cluster binding
M478_RS17165	COG2864	formate dehydrogenase
M478_RS17180	COG3276	selenocysteine insertion sequence binding
M478_RS17215	COG2801	Transposase and inactivated derivatives
M478_RS17230	COG3274	enterobacterial common antigen metabolic process
M478_RS17245	COG3121	Chaperone
M478_RS17255	COG1070	Carbohydrate kinase
M478_RS17265	COG4213	ABC transporter substrate-binding protein
M478_RS17275	COG4214	carbohydrate transport
M478_RS17280	COG2207	Transcriptional regulator
M478_RS17280	COG1609	Transcriptional regulator
M478_RS17285	COG0582	viral genome integration into host DNA
M478_RS17325	COG4604	ABC transporter, ATP-binding protein
M478_RS17330	COG4605	iron ion homeostasis
M478_RS17340	COG4607	ABC-type enterochelin transport system periplasmic component
M478_RS17370	COG2986	histidine ammonia-lyase
M478_RS17385	COG2194	sulfuric ester hydrolase activity
M478_RS17390	COG2197	response regulator
M478_RS17395	COG3851	Histidine kinase
M478_RS17410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M478_RS17425	COG0551	DNA topoisomerase type I activity
M478_RS17435	COG0758	DNA mediated transformation
M478_RS17465	COG3036	rescue of stalled ribosome
M478_RS17470	COG0789	Transcriptional regulator
M478_RS17485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M478_RS17500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M478_RS17505	COG0201	protein transport
M478_RS17515	COG1841	ribosomal large subunit assembly
M478_RS17555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M478_RS17560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M478_RS17570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M478_RS17575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M478_RS17585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M478_RS17595	COG0089	rRNA binding
M478_RS17610	COG0051	transcription antitermination factor activity, RNA binding
M478_RS17640	COG0049	tRNA binding
M478_RS17645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M478_RS17665	COG2964	Protein conserved in bacteria
M478_RS17670	COG0545	Peptidyl-prolyl cis-trans isomerase
M478_RS17680	COG1047	Peptidyl-prolyl cis-trans
M478_RS17685	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M478_RS17705	COG1216	Glycosyl transferase, family 2
M478_RS17715	COG2175	clavaminate synthase activity
M478_RS17720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M478_RS17730	COG4521	taurine ABC transporter
M478_RS17740	COG0429	hydrolase of the alpha beta-hydrolase fold
M478_RS17750	COG3954	Phosphoribulokinase
M478_RS17760	COG1765	OsmC-like protein
M478_RS17770	COG1289	transmembrane transporter activity
M478_RS17785	COG0433	COG0433 Predicted ATPase
M478_RS17790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M478_RS17795	COG1486	melibiose metabolic process
M478_RS17815	COG0402	S-adenosylhomocysteine deaminase activity
M478_RS17820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M478_RS17840	COG0180	Tryptophanyl-tRNA synthetase
M478_RS17845	COG0546	phosphoglycolate phosphatase activity
M478_RS17850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M478_RS17875	COG4796	Type ii and iii secretion system protein
M478_RS17905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M478_RS17910	COG0494	nUDIX hydrolase
M478_RS17925	COG1011	Hydrolase
M478_RS17930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M478_RS17955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M478_RS17960	COG2183	response to ionizing radiation
M478_RS17970	COG1918	ferrous iron import across plasma membrane
M478_RS18005	COG1640	4-alpha-glucanotransferase
M478_RS18010	COG0058	SHG alpha-glucan phosphorylase activity
M478_RS18015	COG0058	SHG alpha-glucan phosphorylase activity
M478_RS18035	COG1349	DNA-binding transcription factor activity
M478_RS18045	COG2801	Transposase and inactivated derivatives
M478_RS18065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M478_RS18070	COG0058	SHG alpha-glucan phosphorylase activity
M478_RS18095	COG3275	phosphorelay sensor kinase activity
M478_RS18125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M478_RS18130	COG2095	MarC family integral membrane protein
M478_RS18150	COG3265	gluconokinase activity
M478_RS18155	COG2610	gluconate transmembrane transporter activity
M478_RS18160	COG1609	Transcriptional regulator
M478_RS18165	COG1741	Belongs to the pirin family
M478_RS18185	COG0191	fructose-bisphosphate aldolase activity
M478_RS18200	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS18215	COG2081	HI0933 family
M478_RS18220	COG0306	phosphate transporter
M478_RS18240	COG0589	response to stress
M478_RS18260	COG0339	signal peptide processing
M478_RS18265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M478_RS18270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M478_RS18275	COG3835	regulator
M478_RS18280	COG2610	gluconate transmembrane transporter activity
M478_RS18285	COG1929	Belongs to the glycerate kinase type-1 family
M478_RS18310	COG1295	ribonuclease BN
M478_RS18315	COG2134	cdp-diacylglycerol pyrophosphatase
M478_RS18320	COG2982	Protein involved in outer membrane biogenesis
M478_RS18325	COG2200	EAL domain
M478_RS18330	COG1942	4-Oxalocrotonate Tautomerase
M478_RS18335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_RS18340	COG0612	Peptidase, M16
M478_RS18360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M478_RS18365	COG2199	diguanylate cyclase activity
M478_RS18365	COG2200	EAL domain
M478_RS18370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M478_RS18375	COG4608	Belongs to the ABC transporter superfamily
M478_RS18380	COG0444	Belongs to the ABC transporter superfamily
M478_RS18385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_RS18390	COG0601	transmembrane transport
M478_RS18395	COG0747	negative chemotaxis
M478_RS18405	COG2831	hemolysin activation secretion protein
M478_RS18420	COG2271	Major facilitator Superfamily
M478_RS18460	COG3162	membrane
M478_RS18470	COG1301	dicarboxylic acid transport
M478_RS18580	COG2391	methyltransferase activity
M478_RS18585	COG0425	Belongs to the sulfur carrier protein TusA family
M478_RS18590	COG0583	DNA-binding transcription factor activity
M478_RS18595	COG0814	amino acid
M478_RS18600	COG0626	cystathionine gamma-synthase activity
M478_RS18610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_RS18615	COG4558	Periplasmic binding protein
M478_RS18620	COG3720	iron ion transport
M478_RS18625	COG4771	TonB-dependent receptor
M478_RS18630	COG0702	epimerase
M478_RS18635	COG3721	Heme iron utilization protein
M478_RS18660	COG1358	cellular component organization or biogenesis
M478_RS18720	COG3121	Chaperone
M478_RS18765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M478_RS18775	COG0735	belongs to the Fur family
M478_RS18780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M478_RS18805	COG1448	Aminotransferase
M478_RS18810	COG2315	Protein conserved in bacteria
M478_RS18815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M478_RS18820	COG0629	single-stranded DNA binding
M478_RS18830	COG1454	alcohol dehydrogenase
M478_RS18900	COG1309	transcriptional regulator
M478_RS18905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_RS18905	COG0493	'glutamate synthase
M478_RS18910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M478_RS18915	COG3383	formate dehydrogenase (NAD+) activity
M478_RS18930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_RS18975	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M478_RS18985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M478_RS18990	COG1053	succinate dehydrogenase
M478_RS19005	COG1511	domain protein
M478_RS19005	COG3264	Mechanosensitive ion channel
M478_RS19025	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M478_RS19040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M478_RS19045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M478_RS19045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M478_RS19050	COG0802	atpase or kinase
M478_RS19055	COG0860	N-Acetylmuramoyl-L-alanine amidase
M478_RS19075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M478_RS19080	COG0330	HflC and HflK could
M478_RS19085	COG0330	HflC and HflK could
M478_RS19090	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M478_RS19105	COG0557	exoribonuclease II activity
M478_RS19110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M478_RS19115	COG1960	acyl-CoA dehydrogenase activity
M478_RS19120	COG3650	response to hydrogen peroxide
M478_RS19140	COG1073	alpha beta
M478_RS19150	COG0360	Binds together with S18 to 16S ribosomal RNA
M478_RS19160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M478_RS19185	COG3061	Opacity-associated protein A
M478_RS19190	COG0545	Peptidyl-prolyl cis-trans isomerase
M478_RS19200	COG0737	Belongs to the 5'-nucleotidase family
M478_RS19210	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M478_RS19220	COG1253	flavin adenine dinucleotide binding
M478_RS19230	COG0729	surface antigen
M478_RS19235	COG2911	Protein conserved in bacteria
M478_RS19240	COG2105	PFAM AIG2 family protein
M478_RS19245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M478_RS19250	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M478_RS19255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M478_RS19280	COG3423	Transcriptional regulator
M478_RS19290	COG0142	geranyltranstransferase activity
M478_RS19305	COG0697	spore germination
M478_RS19315	COG0642	Histidine kinase
M478_RS19320	COG0745	RESPONSE REGULATOR receiver
M478_RS19325	COG2027	D-alanyl-D-alanine carboxypeptidase
M478_RS19335	COG1534	Rna-binding protein
M478_RS19350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M478_RS19360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M478_RS19380	COG0195	Participates in both transcription termination and antitermination
M478_RS19410	COG2801	Transposase and inactivated derivatives
M478_RS19425	COG0513	Belongs to the DEAD box helicase family
M478_RS19445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M478_RS19455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_RS19465	COG0826	peptidase U32
M478_RS19470	COG0826	peptidase U32
M478_RS19480	COG3154	lipid carrier protein
M478_RS19485	COG3153	acetyltransferase
M478_RS19505	COG1653	transport
M478_RS19510	COG1175	transmembrane transport
M478_RS19515	COG0395	ABC-type sugar transport system, permease component
M478_RS19520	COG3842	ATPase activity
M478_RS19535	COG0702	epimerase
M478_RS19540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M478_RS19545	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M478_RS19550	COG3454	Phosphonate metabolism
M478_RS19555	COG4778	phosphonate C-P lyase system protein PhnL
M478_RS19560	COG4107	phosphonate C-P lyase system protein PhnK
M478_RS19565	COG3627	carbon phosphorus lyase activity
M478_RS19570	COG3626	phosphonate metabolism
M478_RS19575	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M478_RS19580	COG3624	Phosphonate C-P lyase system protein PhnG
M478_RS19585	COG2188	Transcriptional regulator
M478_RS19600	COG4608	Belongs to the ABC transporter superfamily
M478_RS19605	COG0444	Belongs to the ABC transporter superfamily
M478_RS19610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M478_RS19615	COG0601	transmembrane transport
M478_RS19625	COG2731	YhcH YjgK YiaL family protein
M478_RS19635	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M478_RS19645	COG0525	valine-tRNA ligase activity
M478_RS19650	COG2927	DNA polymerase III (CHI subunit)
M478_RS19660	COG0795	lipopolysaccharide-transporting ATPase activity
M478_RS19665	COG0795	lipopolysaccharide-transporting ATPase activity
M478_RS19675	COG0582	viral genome integration into host DNA
M478_RS19730	COG1459	type II secretion system
M478_RS19735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M478_RS19740	COG4969	Belongs to the N-Me-Phe pilin family
M478_RS19750	COG3023	N-Acetylmuramoyl-L-alanine amidase
M478_RS19755	COG3725	Membrane protein required for beta-lactamase induction
M478_RS19760	COG1113	amino acid transport
M478_RS19765	COG2186	Transcriptional regulator
M478_RS19770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M478_RS19775	COG0508	dehydrogenase complex catalyzes the overall conversion of
M478_RS19780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M478_RS19795	COG1049	propionate catabolic process, 2-methylcitrate cycle
M478_RS19805	COG0697	spore germination
M478_RS19825	COG2132	Multicopper oxidase
M478_RS19830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M478_RS19835	COG0288	reversible hydration of carbon dioxide
M478_RS19840	COG1131	(ABC) transporter
M478_RS19845	COG0842	Transport permease protein
M478_RS19870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M478_RS19875	COG0617	tRNA 3'-terminal CCA addition
M478_RS19880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M478_RS19895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M478_RS19900	COG1643	Atp-dependent helicase
M478_RS19905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M478_RS19910	COG1120	ATPase activity
M478_RS19915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M478_RS19920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M478_RS19940	COG2860	membrane
M478_RS19960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M478_RS19965	COG2205	protein histidine kinase activity
M478_RS19965	COG3437	response regulator, receiver
M478_RS19965	COG3850	Histidine kinase
M478_RS19965	COG4999	Histidine kinase
M478_RS19970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M478_RS19980	COG3956	TIGRFAM MazG family protein
M478_RS20000	COG0602	queuosine metabolic process
M478_RS20005	COG0720	synthase
M478_RS20055	COG0529	Catalyzes the synthesis of activated sulfate
M478_RS20095	COG4942	peptidase
M478_RS20095	COG1388	LysM domain
M478_RS20100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M478_RS20115	COG0698	ribose 5-phosphate isomerase
M478_RS20120	COG1063	alcohol dehydrogenase
M478_RS20125	COG1028	Short-chain dehydrogenase reductase Sdr
M478_RS20130	COG2376	Dihydroxyacetone kinase
M478_RS20145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M478_RS20165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M478_RS20170	COG1858	cytochrome C peroxidase
M478_RS20180	COG4771	TonB-dependent receptor
M478_RS20195	COG0024	Methionine aminopeptidase
M478_RS20205	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M478_RS20205	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M478_RS20210	COG1070	Carbohydrate kinase
M478_RS20215	COG3623	hexulose-6-phosphate isomerase
M478_RS20220	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS20225	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS20230	COG1129	ABC transporter
M478_RS20245	COG1349	DNA-binding transcription factor activity
M478_RS20250	COG0235	Class ii aldolase
M478_RS20255	COG0243	molybdopterin cofactor binding
M478_RS20260	COG0437	4 iron, 4 sulfur cluster binding
M478_RS20265	COG3302	dmso reductase anchor subunit
M478_RS20270	COG3381	protein complex oligomerization
M478_RS20275	COG3038	cytochrome b561
M478_RS20280	COG3783	Cytochrome b(562)
M478_RS20290	COG1879	ABC-type sugar transport system periplasmic component
M478_RS20300	COG1129	ABC transporter
M478_RS20305	COG1172	Belongs to the binding-protein-dependent transport system permease family
M478_RS20310	COG3959	Transketolase, thiamine diphosphate binding domain
M478_RS20315	COG3958	Transketolase
M478_RS20320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M478_RS20365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M478_RS20390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M478_RS20395	COG1238	metal cluster binding
M478_RS20400	COG2918	glutathione biosynthetic process
M478_RS20420	COG4536	flavin adenine dinucleotide binding
M478_RS20425	COG4137	Cytochrome C assembly protein
M478_RS20430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M478_RS20465	COG3137	Salt-induced outer membrane protein
M478_RS20470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_RS20475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_RS20480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M478_RS20485	COG3279	Response regulator of the LytR AlgR family
M478_RS20490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M478_RS20495	COG0287	Prephenate dehydrogenase
M478_RS20495	COG1605	Chorismate mutase
M478_RS20500	COG1605	Chorismate mutase
M478_RS20500	COG0077	Prephenate dehydratase
M478_RS20520	COG0077	Prephenate dehydratase
M478_RS20520	COG1605	Chorismate mutase
M478_RS20535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M478_RS20540	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M478_RS20545	COG0564	pseudouridine synthase activity
M478_RS20555	COG0542	response to heat
M478_RS20590	COG5544	Lipoprotein
M478_RS20595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M478_RS20600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M478_RS20600	COG1042	CoA-binding domain protein
M478_RS20600	COG0045	succinate-CoA ligase (ADP-forming) activity
M478_RS20605	COG3148	PFAM DTW domain containing protein
M478_RS20610	COG3118	belongs to the thioredoxin family
M478_RS20615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M478_RS20620	COG2814	Major facilitator Superfamily
M478_RS20625	COG1566	PFAM secretion protein HlyD family protein
M478_RS20630	COG1846	Transcriptional regulator
M478_RS20640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M478_RS20645	COG2814	Major facilitator Superfamily
M478_RS20685	COG0765	amino acid transport
M478_RS20695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M478_RS20710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M478_RS20735	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
M478_RS20745	COG1960	acyl-CoA dehydrogenase activity
M478_RS20755	COG0121	glutamine amidotransferase
M478_RS20760	COG3034	peptidoglycan biosynthetic process
M478_RS20770	COG1805	sodium ion transport
M478_RS20775	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M478_RS20795	COG1477	protein flavinylation
M478_RS20815	COG2195	Cleaves the N-terminal amino acid of tripeptides
M478_RS20875	COG2226	methyltransferase
M478_RS20910	COG1940	carbohydrate kinase activity
M478_RS20915	COG0419	ATPase involved in DNA repair
M478_RS20920	COG0420	3'-5' exonuclease activity
M478_RS20930	COG0745	RESPONSE REGULATOR receiver
M478_RS20935	COG5002	protein histidine kinase activity
M478_RS20960	COG0366	Alpha amylase catalytic
M478_RS20985	COG0450	alkyl hydroperoxide reductase
M478_RS21005	COG1862	Preprotein translocase
M478_RS21010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M478_RS21015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M478_RS21040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M478_RS21040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M478_RS21055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M478_RS21060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M478_RS21080	COG0142	geranyltranstransferase activity
M478_RS21100	COG0693	protein deglycase activity
M478_RS21105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M478_RS21115	COG2814	Major facilitator Superfamily
M478_RS21125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M478_RS21130	COG1845	cytochrome c oxidase, subunit III
M478_RS21135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M478_RS21140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M478_RS21150	COG2223	nitrite transmembrane transporter activity
M478_RS21155	COG3056	Lipoprotein
M478_RS21160	COG0271	Belongs to the BolA IbaG family
M478_RS21185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M478_RS21190	COG0776	regulation of translation
M478_RS21195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M478_RS21200	COG1555	photosystem II stabilization
M478_RS21205	COG0824	Thioesterase
M478_RS21215	COG4533	DNA binding
M478_RS21230	COG1522	sequence-specific DNA binding
M478_RS21235	COG1132	(ABC) transporter
M478_RS21240	COG1132	(ABC) transporter
M478_RS21245	COG0347	Belongs to the P(II) protein family
M478_RS21250	COG0004	ammonium transporteR
M478_RS21255	COG1946	Acyl-CoA thioesterase
M478_RS21260	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M478_RS21265	COG3695	enzyme binding
M478_RS21285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M478_RS21295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M478_RS21300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M478_RS21305	COG1309	transcriptional regulator
M478_RS21310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M478_RS21315	COG3264	Mechanosensitive ion channel
M478_RS21315	COG1196	nuclear chromosome segregation
M478_RS21340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M478_RS21370	COG0543	2 iron, 2 sulfur cluster binding
M478_RS21370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M478_RS21395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_RS21435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M478_RS21455	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
M478_RS21460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M478_RS21465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M478_RS21465	COG4651	solute:proton antiporter activity
M478_RS21470	COG2223	nitrite transmembrane transporter activity
M478_RS21475	COG0737	Belongs to the 5'-nucleotidase family
M478_RS21480	COG0737	Belongs to the 5'-nucleotidase family
M478_RS21485	COG0737	Belongs to the 5'-nucleotidase family
M478_RS21500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M478_RS21505	COG3735	TraB family
M478_RS21510	COG2217	Heavy metal translocating P-type atpase
M478_RS21515	COG0789	Transcriptional regulator
M478_RS21520	COG1585	Membrane protein implicated in regulation of membrane protease activity
M478_RS21525	COG0330	HflC and HflK could
M478_RS21530	COG3118	belongs to the thioredoxin family
M478_RS21535	COG0300	oxidoreductase activity
M478_RS21540	COG2755	lipolytic protein G-D-S-L family
M478_RS21545	COG4181	ATPase activity
M478_RS21550	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M478_RS21555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M478_RS21560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M478_RS21570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M478_RS21590	COG2501	S4 domain
M478_RS21640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M478_RS21645	COG4589	Belongs to the CDS family
M478_RS21655	COG2267	carboxylic ester hydrolase activity
M478_RS21660	COG2453	phosphatase
M478_RS21660	COG0671	phosphoesterase, PA-phosphatase related
M478_RS21690	COG0667	Aldo Keto reductase
M478_RS21695	COG0656	L-ascorbic acid biosynthetic process
M478_RS21715	COG1472	Belongs to the glycosyl hydrolase 3 family
M478_RS21730	COG3328	transposase activity
M478_RS21735	COG2850	peptidyl-arginine hydroxylation
M478_RS21785	COG3423	Transcriptional regulator
M478_RS21790	COG4953	penicillin-binding protein 1C
M478_RS21805	COG2373	Large extracellular alpha-helical protein
M478_RS21825	COG3962	Belongs to the TPP enzyme family