locus-tag	class	description
ISU64_RS00010	COG0592	DNA-directed DNA polymerase activity
ISU64_RS00025	COG0187	DNA topoisomerase II activity
ISU64_RS00030	COG0561	phosphatase activity
ISU64_RS00040	COG1349	DNA-binding transcription factor activity
ISU64_RS00060	COG0058	SHG alpha-glucan phosphorylase activity
ISU64_RS00065	COG1640	4-alpha-glucanotransferase
ISU64_RS00105	COG1918	ferrous iron import across plasma membrane
ISU64_RS00110	COG2183	response to ionizing radiation
ISU64_RS00115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU64_RS00140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU64_RS00145	COG1011	Hydrolase
ISU64_RS00155	COG0494	nUDIX hydrolase
ISU64_RS00160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU64_RS00185	COG4796	Type ii and iii secretion system protein
ISU64_RS00210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU64_RS00215	COG0546	phosphoglycolate phosphatase activity
ISU64_RS00220	COG0180	Tryptophanyl-tRNA synthetase
ISU64_RS00240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU64_RS00245	COG0402	S-adenosylhomocysteine deaminase activity
ISU64_RS00270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU64_RS00275	COG0433	COG0433 Predicted ATPase
ISU64_RS00290	COG1289	transmembrane transporter activity
ISU64_RS00300	COG1765	OsmC-like protein
ISU64_RS00310	COG3954	Phosphoribulokinase
ISU64_RS00320	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU64_RS00330	COG4521	taurine ABC transporter
ISU64_RS00340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU64_RS00345	COG2175	clavaminate synthase activity
ISU64_RS00355	COG1216	Glycosyl transferase, family 2
ISU64_RS00360	COG0488	(ABC) transporter
ISU64_RS00375	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU64_RS00380	COG1047	Peptidyl-prolyl cis-trans
ISU64_RS00390	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU64_RS00395	COG2964	Protein conserved in bacteria
ISU64_RS00420	COG0049	tRNA binding
ISU64_RS00450	COG0051	transcription antitermination factor activity, RNA binding
ISU64_RS00465	COG0089	rRNA binding
ISU64_RS00475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU64_RS00485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU64_RS00490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU64_RS00500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU64_RS00505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU64_RS00545	COG1841	ribosomal large subunit assembly
ISU64_RS00555	COG0201	protein transport
ISU64_RS00560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU64_RS00575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU64_RS00590	COG0789	Transcriptional regulator
ISU64_RS00595	COG3036	rescue of stalled ribosome
ISU64_RS00625	COG0758	DNA mediated transformation
ISU64_RS00635	COG0551	DNA topoisomerase type I activity
ISU64_RS00650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU64_RS00700	COG3162	membrane
ISU64_RS00710	COG1301	dicarboxylic acid transport
ISU64_RS00820	COG2391	methyltransferase activity
ISU64_RS00825	COG0425	Belongs to the sulfur carrier protein TusA family
ISU64_RS00830	COG0583	DNA-binding transcription factor activity
ISU64_RS00835	COG0814	amino acid
ISU64_RS00840	COG0626	cystathionine gamma-synthase activity
ISU64_RS00850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS00855	COG4558	Periplasmic binding protein
ISU64_RS00860	COG3720	iron ion transport
ISU64_RS00865	COG4771	TonB-dependent receptor
ISU64_RS00875	COG0702	epimerase
ISU64_RS00880	COG3721	Heme iron utilization protein
ISU64_RS00905	COG1358	cellular component organization or biogenesis
ISU64_RS00965	COG3121	Chaperone
ISU64_RS01005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU64_RS01015	COG0735	belongs to the Fur family
ISU64_RS01020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU64_RS01045	COG1448	Aminotransferase
ISU64_RS01050	COG2315	Protein conserved in bacteria
ISU64_RS01055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU64_RS01060	COG0629	single-stranded DNA binding
ISU64_RS01070	COG1454	alcohol dehydrogenase
ISU64_RS01130	COG1309	transcriptional regulator
ISU64_RS01135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU64_RS01135	COG0493	'glutamate synthase
ISU64_RS01140	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU64_RS01145	COG3383	formate dehydrogenase (NAD+) activity
ISU64_RS01160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISU64_RS01205	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU64_RS01215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU64_RS01220	COG1053	succinate dehydrogenase
ISU64_RS01235	COG1511	domain protein
ISU64_RS01235	COG3264	Mechanosensitive ion channel
ISU64_RS01250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU64_RS01260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU64_RS01265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU64_RS01265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU64_RS01270	COG0802	atpase or kinase
ISU64_RS01275	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU64_RS01295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU64_RS01300	COG0330	HflC and HflK could
ISU64_RS01305	COG0330	HflC and HflK could
ISU64_RS01310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU64_RS01325	COG0557	exoribonuclease II activity
ISU64_RS01330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU64_RS01335	COG1960	acyl-CoA dehydrogenase activity
ISU64_RS01340	COG3650	response to hydrogen peroxide
ISU64_RS01355	COG1073	alpha beta
ISU64_RS01360	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU64_RS01370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU64_RS01390	COG3061	Opacity-associated protein A
ISU64_RS01395	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU64_RS01405	COG0737	Belongs to the 5'-nucleotidase family
ISU64_RS01415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU64_RS01425	COG1253	flavin adenine dinucleotide binding
ISU64_RS01435	COG0729	surface antigen
ISU64_RS01440	COG2911	Protein conserved in bacteria
ISU64_RS01445	COG2105	PFAM AIG2 family protein
ISU64_RS01450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU64_RS01460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU64_RS01480	COG3423	Transcriptional regulator
ISU64_RS01490	COG0142	geranyltranstransferase activity
ISU64_RS01505	COG0697	spore germination
ISU64_RS01520	COG0745	RESPONSE REGULATOR receiver
ISU64_RS01525	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU64_RS01535	COG1534	Rna-binding protein
ISU64_RS01550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU64_RS01560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU64_RS01580	COG0195	Participates in both transcription termination and antitermination
ISU64_RS01620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU64_RS01635	COG1629	transport
ISU64_RS01660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU64_RS01665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU64_RS01665	COG0678	peroxiredoxin activity
ISU64_RS01725	COG5544	Lipoprotein
ISU64_RS01730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU64_RS01735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU64_RS01735	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU64_RS01735	COG1042	CoA-binding domain protein
ISU64_RS01740	COG3148	PFAM DTW domain containing protein
ISU64_RS01745	COG3118	belongs to the thioredoxin family
ISU64_RS01750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU64_RS01755	COG2814	Major facilitator Superfamily
ISU64_RS01760	COG1566	PFAM secretion protein HlyD family protein
ISU64_RS01765	COG1846	Transcriptional regulator
ISU64_RS01775	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU64_RS01780	COG2814	Major facilitator Superfamily
ISU64_RS01815	COG0765	amino acid transport
ISU64_RS01825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU64_RS01840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU64_RS01855	COG0436	Aminotransferase
ISU64_RS01895	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU64_RS01910	COG1960	acyl-CoA dehydrogenase activity
ISU64_RS01920	COG0121	glutamine amidotransferase
ISU64_RS01925	COG3034	peptidoglycan biosynthetic process
ISU64_RS01935	COG1805	sodium ion transport
ISU64_RS01940	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU64_RS01960	COG1477	protein flavinylation
ISU64_RS01980	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU64_RS01985	COG0583	DNA-binding transcription factor activity
ISU64_RS02035	COG2226	methyltransferase
ISU64_RS02060	COG1940	carbohydrate kinase activity
ISU64_RS02065	COG0419	ATPase involved in DNA repair
ISU64_RS02070	COG0420	3'-5' exonuclease activity
ISU64_RS02075	COG0745	RESPONSE REGULATOR receiver
ISU64_RS02080	COG5002	protein histidine kinase activity
ISU64_RS02100	COG0366	Alpha amylase catalytic
ISU64_RS02125	COG0450	alkyl hydroperoxide reductase
ISU64_RS02145	COG1862	Preprotein translocase
ISU64_RS02150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU64_RS02155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU64_RS02180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU64_RS02180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU64_RS02195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU64_RS02200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU64_RS02215	COG0142	geranyltranstransferase activity
ISU64_RS02230	COG0693	protein deglycase activity
ISU64_RS02235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU64_RS02245	COG2814	Major facilitator Superfamily
ISU64_RS02255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU64_RS02260	COG1845	cytochrome c oxidase, subunit III
ISU64_RS02265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU64_RS02270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU64_RS02280	COG2223	nitrite transmembrane transporter activity
ISU64_RS02285	COG3056	Lipoprotein
ISU64_RS02290	COG0271	Belongs to the BolA IbaG family
ISU64_RS02310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU64_RS02315	COG0776	regulation of translation
ISU64_RS02325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU64_RS02330	COG1555	photosystem II stabilization
ISU64_RS02335	COG0824	Thioesterase
ISU64_RS02345	COG4533	DNA binding
ISU64_RS02360	COG1522	sequence-specific DNA binding
ISU64_RS02365	COG1132	(ABC) transporter
ISU64_RS02370	COG1132	(ABC) transporter
ISU64_RS02375	COG0347	Belongs to the P(II) protein family
ISU64_RS02380	COG0004	ammonium transporteR
ISU64_RS02385	COG1946	Acyl-CoA thioesterase
ISU64_RS02390	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU64_RS02395	COG3695	enzyme binding
ISU64_RS02420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU64_RS02430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU64_RS02435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU64_RS02440	COG1309	transcriptional regulator
ISU64_RS02445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU64_RS02450	COG3264	Mechanosensitive ion channel
ISU64_RS02450	COG1196	nuclear chromosome segregation
ISU64_RS02465	COG2832	Protein of unknown function (DUF454)
ISU64_RS02475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU64_RS02505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU64_RS02505	COG0543	2 iron, 2 sulfur cluster binding
ISU64_RS02525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU64_RS02570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU64_RS02590	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU64_RS02595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU64_RS02600	COG4651	solute:proton antiporter activity
ISU64_RS02600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU64_RS02620	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU64_RS02625	COG3735	TraB family
ISU64_RS02630	COG2217	Heavy metal translocating P-type atpase
ISU64_RS02635	COG0789	Transcriptional regulator
ISU64_RS02640	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU64_RS02645	COG0330	HflC and HflK could
ISU64_RS02650	COG3118	belongs to the thioredoxin family
ISU64_RS02655	COG0300	oxidoreductase activity
ISU64_RS02660	COG2755	lipolytic protein G-D-S-L family
ISU64_RS02665	COG4181	ATPase activity
ISU64_RS02670	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU64_RS02675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU64_RS02680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU64_RS02690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU64_RS02705	COG2501	S4 domain
ISU64_RS02740	COG0582	viral genome integration into host DNA
ISU64_RS02750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU64_RS02755	COG4589	Belongs to the CDS family
ISU64_RS02765	COG2267	carboxylic ester hydrolase activity
ISU64_RS02800	COG0667	Aldo Keto reductase
ISU64_RS02805	COG0656	L-ascorbic acid biosynthetic process
ISU64_RS02815	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU64_RS02830	COG3328	transposase activity
ISU64_RS02835	COG1278	Cold shock
ISU64_RS02845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU64_RS02850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU64_RS02870	COG1686	Belongs to the peptidase S11 family
ISU64_RS02875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU64_RS02880	COG0772	Belongs to the SEDS family
ISU64_RS02885	COG0768	penicillin binding
ISU64_RS02895	COG0799	negative regulation of ribosome biogenesis
ISU64_RS02905	COG1466	dna polymerase III delta subunit
ISU64_RS02920	COG2888	peptidyl-tyrosine sulfation
ISU64_RS02925	COG1126	abc transporter atp-binding protein
ISU64_RS02930	COG0765	amino acid transport
ISU64_RS02935	COG0765	amino acid transport
ISU64_RS02945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU64_RS02950	COG4535	Mg2 and Co2 transporter CorC
ISU64_RS02960	COG1702	phosphate starvation-inducible protein PhoH
ISU64_RS02970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU64_RS03005	COG0367	asparagine synthase
ISU64_RS03010	COG0647	UMP catabolic process
ISU64_RS03015	COG1846	Transcriptional regulator
ISU64_RS03015	COG1940	carbohydrate kinase activity
ISU64_RS03020	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU64_RS03030	COG1263	PTS System
ISU64_RS03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU64_RS03030	COG2190	(PTS) system
ISU64_RS03055	COG0735	belongs to the Fur family
ISU64_RS03070	COG0596	Alpha beta hydrolase
ISU64_RS03080	COG0582	viral genome integration into host DNA
ISU64_RS03110	COG3657	addiction module killer protein
ISU64_RS03150	COG3328	transposase activity
ISU64_RS03165	COG0582	viral genome integration into host DNA
ISU64_RS03185	COG2867	negative regulation of translational initiation
ISU64_RS03195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU64_RS03200	COG0497	DNA recombination
ISU64_RS03205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU64_RS03220	COG2009	succinate dehydrogenase
ISU64_RS03225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU64_RS03230	COG1053	succinate dehydrogenase
ISU64_RS03240	COG0567	Dehydrogenase, E1 component
ISU64_RS03245	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU64_RS03255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU64_RS03265	COG1271	oxidase subunit
ISU64_RS03270	COG1294	oxidase, subunit
ISU64_RS03275	COG4890	Cyd operon protein YbgT
ISU64_RS03280	COG3790	cyd operon protein YbgE
ISU64_RS03285	COG0824	Thioesterase
ISU64_RS03290	COG0811	peptide transport
ISU64_RS03295	COG0848	biopolymer transport protein
ISU64_RS03300	COG3064	Membrane
ISU64_RS03300	COG3064	Membrane
ISU64_RS03310	COG2885	chlorophyll binding
ISU64_RS03315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU64_RS03350	COG1230	cation diffusion facilitator family transporter
ISU64_RS03370	COG2017	converts alpha-aldose to the beta-anomer
ISU64_RS03385	COG1085	galactose-1-phosphate uridylyltransferase
ISU64_RS03390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU64_RS03400	COG1119	ATPase activity
ISU64_RS03405	COG2005	Transcriptional regulator
ISU64_RS03405	COG3585	molybdate ion transport
ISU64_RS03415	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU64_RS03420	COG4149	molybdate abc transporter
ISU64_RS03430	COG0561	phosphatase activity
ISU64_RS03455	COG2226	methyltransferase
ISU64_RS03465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU64_RS03475	COG4628	conserved protein (DUF2132)
ISU64_RS03480	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU64_RS03485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU64_RS03495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU64_RS03500	COG0314	molybdopterin synthase activity
ISU64_RS03505	COG0670	Belongs to the BI1 family
ISU64_RS03530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU64_RS03535	COG0583	DNA-binding transcription factor activity
ISU64_RS03545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ISU64_RS03565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU64_RS03575	COG1686	Belongs to the peptidase S11 family
ISU64_RS03580	COG0277	FAD linked oxidase domain protein
ISU64_RS03600	COG2261	transglycosylase associated protein
ISU64_RS03610	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU64_RS03625	COG4807	Protein conserved in bacteria
ISU64_RS03645	COG1122	ATPase activity
ISU64_RS03665	COG2897	thiosulfate sulfurtransferase activity
ISU64_RS03670	COG1732	Glycine betaine
ISU64_RS03675	COG1174	glycine betaine transport
ISU64_RS03680	COG1125	glycine betaine transport
ISU64_RS03685	COG1174	glycine betaine transport
ISU64_RS03690	COG0531	amino acid
ISU64_RS03700	COG3328	transposase activity
ISU64_RS03715	COG0697	spore germination
ISU64_RS03740	COG0814	amino acid
ISU64_RS03755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU64_RS03780	COG2205	protein histidine kinase activity
ISU64_RS03780	COG0784	Response regulator, receiver
ISU64_RS03790	COG0642	Histidine kinase
ISU64_RS03790	COG2198	Histidine kinase
ISU64_RS03795	COG0642	Histidine kinase
ISU64_RS03795	COG2198	Histidine kinase
ISU64_RS03800	COG2223	nitrite transmembrane transporter activity
ISU64_RS03820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU64_RS03860	COG3395	kinase activity
ISU64_RS03865	COG0235	Class ii aldolase
ISU64_RS03870	COG1349	DNA-binding transcription factor activity
ISU64_RS03875	COG3622	Belongs to the hyi family
ISU64_RS03895	COG4386	tail sheath protein
ISU64_RS03935	COG3299	homolog of phage Mu protein gp47
ISU64_RS03955	COG1737	Transcriptional regulator
ISU64_RS03960	COG2723	6-phospho-beta-galactosidase activity
ISU64_RS03980	COG3157	Type VI secretion system effector, Hcp
ISU64_RS03995	COG3083	sulfuric ester hydrolase activity
ISU64_RS04000	COG3082	Protein of unknown function (DUF1414)
ISU64_RS04020	COG1061	Type III restriction enzyme res subunit
ISU64_RS04025	COG1187	pseudouridine synthase activity
ISU64_RS04030	COG2814	Major facilitator Superfamily
ISU64_RS04040	COG4172	Belongs to the ABC transporter superfamily
ISU64_RS04045	COG4239	(ABC) transporter, permease
ISU64_RS04050	COG4174	ABC transporter (Permease)
ISU64_RS04055	COG4166	transmembrane transport
ISU64_RS04060	COG2200	EAL domain
ISU64_RS04065	COG0791	NLP P60 protein
ISU64_RS04070	COG0671	phosphoesterase, PA-phosphatase related
ISU64_RS04075	COG0523	cobalamin synthesis protein
ISU64_RS04085	COG0246	Mannitol dehydrogenase
ISU64_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS04145	COG1129	ABC transporter
ISU64_RS04155	COG0494	nUDIX hydrolase
ISU64_RS04165	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU64_RS04170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU64_RS04170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU64_RS04170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU64_RS04175	COG3710	Transcriptional regulator
ISU64_RS04190	COG3121	Chaperone
ISU64_RS04195	COG3188	usher protein
ISU64_RS04205	COG2855	membrane
ISU64_RS04210	COG0583	DNA-binding transcription factor activity
ISU64_RS04215	COG0833	amino acid
ISU64_RS04230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS04240	COG4771	TonB-dependent receptor
ISU64_RS04245	COG0625	glutathione transferase activity
ISU64_RS04270	COG2011	ABC-type metal ion transport system permease component
ISU64_RS04275	COG1686	Belongs to the peptidase S11 family
ISU64_RS04280	COG0814	amino acid
ISU64_RS04285	COG1349	DNA-binding transcription factor activity
ISU64_RS04295	COG0671	phosphoesterase, PA-phosphatase related
ISU64_RS04325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU64_RS04330	COG3842	ATPase activity
ISU64_RS04335	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU64_RS04340	COG1177	transmembrane transport
ISU64_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS04385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS04390	COG1120	ATPase activity
ISU64_RS04410	COG4160	amino acid transport
ISU64_RS04415	COG4215	(ABC) transporter
ISU64_RS04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS04425	COG1126	abc transporter atp-binding protein
ISU64_RS04430	COG1605	Chorismate mutase
ISU64_RS04440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU64_RS04445	COG0702	epimerase
ISU64_RS04450	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU64_RS04460	COG0028	Belongs to the TPP enzyme family
ISU64_RS04465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU64_RS04475	COG2431	L-lysine efflux transmembrane transporter activity
ISU64_RS04480	COG3593	DNA synthesis involved in DNA repair
ISU64_RS04485	COG2990	Protein conserved in bacteria
ISU64_RS04490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU64_RS04500	COG1278	Cold shock
ISU64_RS04510	COG0542	response to heat
ISU64_RS04520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU64_RS04530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU64_RS04540	COG0492	ferredoxin-NADP+ reductase activity
ISU64_RS04550	COG1674	ftsk spoiiie
ISU64_RS04550	COG3107	peptidoglycan biosynthetic process
ISU64_RS04560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU64_RS04575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU64_RS04585	COG1882	Formate acetyltransferase
ISU64_RS04590	COG2116	formate transmembrane transporter activity
ISU64_RS04595	COG1944	ATP diphosphatase activity
ISU64_RS04600	COG0252	asparaginase activity
ISU64_RS04605	COG5295	Hep Hag repeat protein
ISU64_RS04605	COG5295	Hep Hag repeat protein
ISU64_RS04630	COG0539	negative regulation of cytoplasmic translation
ISU64_RS04640	COG0658	competence protein
ISU64_RS04640	COG2333	competence protein COMEC
ISU64_RS04655	COG5383	Protein conserved in bacteria
ISU64_RS04660	COG1278	Cold shock
ISU64_RS04675	COG3173	Aminoglycoside phosphotransferase
ISU64_RS04680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU64_RS04705	COG2989	Protein conserved in bacteria
ISU64_RS04710	COG3108	Peptidase M15
ISU64_RS04715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU64_RS04725	COG1448	Aminotransferase
ISU64_RS04745	COG0308	aminopeptidase N
ISU64_RS04760	COG0633	Ferredoxin
ISU64_RS04760	COG3217	Mosc domain protein beta barrel domain protein
ISU64_RS04770	COG0488	(ABC) transporter
ISU64_RS04775	COG2995	paraquat-inducible protein a
ISU64_RS04780	COG3008	intermembrane lipid transfer
ISU64_RS04780	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU64_RS04785	COG3009	Protein conserved in bacteria
ISU64_RS04790	COG3130	regulation of translation
ISU64_RS04800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU64_RS04805	COG1737	Transcriptional regulator
ISU64_RS04815	COG0560	Phosphoserine phosphatase
ISU64_RS04860	COG2205	protein histidine kinase activity
ISU64_RS04865	COG3170	Tfp pilus assembly protein FimV
ISU64_RS04870	COG2204	response regulator
ISU64_RS04875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU64_RS04875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU64_RS04880	COG0347	Belongs to the P(II) protein family
ISU64_RS04885	COG2188	Transcriptional regulator
ISU64_RS04900	COG1017	nitric oxide dioxygenase activity
ISU64_RS04900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU64_RS04920	COG2814	Major facilitator Superfamily
ISU64_RS04925	COG3711	transcriptional antiterminator
ISU64_RS04930	COG3683	transport system, periplasmic component
ISU64_RS04935	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU64_RS04955	COG1104	cysteine desulfurase activity
ISU64_RS04960	COG0822	iron-sulfur transferase activity
ISU64_RS04975	COG0443	Heat shock 70 kDa protein
ISU64_RS04980	COG0633	Ferredoxin
ISU64_RS04985	COG2975	iron-sulfur cluster assembly
ISU64_RS05010	COG3468	outer membrane autotransporter barrel domain protein
ISU64_RS05015	COG3468	outer membrane autotransporter barrel domain protein
ISU64_RS05055	COG2976	Protein conserved in bacteria
ISU64_RS05060	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU64_RS05075	COG1645	bacterial-type flagellum-dependent swarming motility
ISU64_RS05085	COG0517	IMP dehydrogenase activity
ISU64_RS05085	COG0516	GMP reductase activity
ISU64_RS05130	COG3328	transposase activity
ISU64_RS05145	COG0351	phosphomethylpyrimidine kinase
ISU64_RS05165	COG0826	peptidase U32
ISU64_RS05170	COG3422	double-strand break repair
ISU64_RS05175	COG0745	RESPONSE REGULATOR receiver
ISU64_RS05180	COG2205	protein histidine kinase activity
ISU64_RS05205	COG3842	ATPase activity
ISU64_RS05215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU64_RS05225	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU64_RS05230	COG1177	transmembrane transport
ISU64_RS05235	COG0443	Heat shock 70 kDa protein
ISU64_RS05240	COG2239	Acts as a magnesium transporter
ISU64_RS05255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU64_RS05265	COG0581	inorganic phosphate transmembrane transporter activity
ISU64_RS05280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU64_RS05285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU64_RS05310	COG1393	Belongs to the ArsC family
ISU64_RS05315	COG4783	chaperone-mediated protein folding
ISU64_RS05320	COG0628	permease
ISU64_RS05330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU64_RS05335	COG2716	regulation of RNA biosynthetic process
ISU64_RS05345	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU64_RS05360	COG2321	neutral zinc metallopeptidase
ISU64_RS05380	COG1876	peptidase activity
ISU64_RS05390	COG1393	Belongs to the ArsC family
ISU64_RS05405	COG1175	transmembrane transport
ISU64_RS05410	COG3842	ATPase activity
ISU64_RS05420	COG3119	arylsulfatase activity
ISU64_RS05425	COG0641	radical SAM
ISU64_RS05430	COG1988	membrane-bound metal-dependent
ISU64_RS05440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU64_RS05450	COG2197	response regulator
ISU64_RS05455	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU64_RS05455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU64_RS05460	COG3062	negative regulation of establishment of protein localization
ISU64_RS05470	COG3043	anaerobic respiration
ISU64_RS05475	COG3005	denitrification pathway
ISU64_RS05515	COG3111	PFAM Bacterial OB fold (BOF) protein
ISU64_RS05525	COG2837	iron assimilation
ISU64_RS05530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU64_RS05540	COG4886	Leucine-rich repeat (LRR) protein
ISU64_RS05550	COG2731	YhcH YjgK YiaL family protein
ISU64_RS05555	COG1737	Transcriptional regulator
ISU64_RS05565	COG4150	thiosulfate binding
ISU64_RS05570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU64_RS05580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU64_RS05595	COG0745	RESPONSE REGULATOR receiver
ISU64_RS05600	COG3850	Histidine kinase
ISU64_RS05600	COG5002	protein histidine kinase activity
ISU64_RS05610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU64_RS05630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU64_RS05645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU64_RS05650	COG0745	RESPONSE REGULATOR receiver
ISU64_RS05655	COG2205	protein histidine kinase activity
ISU64_RS05675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS05685	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU64_RS05700	COG3530	Putative quorum-sensing-regulated virulence factor
ISU64_RS05775	COG0667	Aldo Keto reductase
ISU64_RS05800	COG0436	Aminotransferase
ISU64_RS05805	COG3038	cytochrome b561
ISU64_RS05835	COG3381	protein complex oligomerization
ISU64_RS05840	COG3302	dmso reductase anchor subunit
ISU64_RS05845	COG0437	4 iron, 4 sulfur cluster binding
ISU64_RS05850	COG0243	molybdopterin cofactor binding
ISU64_RS05885	COG2951	lytic endotransglycosylase activity
ISU64_RS05945	COG3121	Chaperone
ISU64_RS05950	COG3188	usher protein
ISU64_RS05955	COG3328	transposase activity
ISU64_RS05960	COG3188	usher protein
ISU64_RS06050	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU64_RS06060	COG1704	LemA family
ISU64_RS06080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU64_RS06085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU64_RS06090	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU64_RS06100	COG1138	Cytochrome C-type biogenesis protein
ISU64_RS06105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU64_RS06110	COG4235	cytochrome complex assembly
ISU64_RS06110	COG3088	subunit of a heme lyase
ISU64_RS06115	COG4235	cytochrome complex assembly
ISU64_RS06115	COG3088	subunit of a heme lyase
ISU64_RS06130	COG3691	Protein conserved in bacteria
ISU64_RS06145	COG2062	phosphohistidine phosphatase, SixA
ISU64_RS06155	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU64_RS06170	COG0730	response to heat
ISU64_RS06175	COG3101	peptidyl-lysine hydroxylation
ISU64_RS06190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU64_RS06195	COG1794	racemase activity, acting on amino acids and derivatives
ISU64_RS06210	COG0697	spore germination
ISU64_RS06225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU64_RS06235	COG0586	Pfam SNARE associated Golgi protein
ISU64_RS06245	COG0285	dihydrofolate synthase activity
ISU64_RS06250	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU64_RS06255	COG1286	toxin biosynthetic process
ISU64_RS06260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU64_RS06270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS06275	COG4215	(ABC) transporter
ISU64_RS06280	COG4160	amino acid transport
ISU64_RS06285	COG4598	ABC transporter
ISU64_RS06290	COG1090	epimerase
ISU64_RS06305	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU64_RS06310	COG3037	sugar-specific permease SgaT UlaA
ISU64_RS06315	COG3328	transposase activity
ISU64_RS06330	COG1609	Transcriptional regulator
ISU64_RS06335	COG0280	phosphate acetyltransferase
ISU64_RS06335	COG0857	belongs to the CobB CobQ family
ISU64_RS06355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU64_RS06360	COG0490	domain, Protein
ISU64_RS06360	COG0471	metal ion transport
ISU64_RS06370	COG0436	Aminotransferase
ISU64_RS06375	COG0583	DNA-binding transcription factor activity
ISU64_RS06385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU64_RS06405	COG1034	ATP synthesis coupled electron transport
ISU64_RS06420	COG0839	Belongs to the complex I subunit 6 family
ISU64_RS06430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU64_RS06435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU64_RS06450	COG2731	YhcH YjgK YiaL family protein
ISU64_RS06455	COG3265	gluconokinase activity
ISU64_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS06465	COG1649	PFAM Uncharacterised BCR, COG1649
ISU64_RS06470	COG1609	Transcriptional regulator
ISU64_RS06475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU64_RS06490	COG0129	dihydroxy-acid dehydratase activity
ISU64_RS06495	COG4575	ribosome binding
ISU64_RS06505	COG1169	isochorismate synthase
ISU64_RS06520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU64_RS06535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU64_RS06560	COG1126	abc transporter atp-binding protein
ISU64_RS06565	COG0765	amino acid transport
ISU64_RS06570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS06600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU64_RS06620	COG1063	alcohol dehydrogenase
ISU64_RS06625	COG1879	ABC-type sugar transport system periplasmic component
ISU64_RS06635	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS06640	COG1609	Transcriptional regulator
ISU64_RS06645	COG0583	DNA-binding transcription factor activity
ISU64_RS06650	COG0473	3-isopropylmalate dehydrogenase activity
ISU64_RS06660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU64_RS06675	COG4638	Rieske (2fe-2S)
ISU64_RS06680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU64_RS06685	COG2831	hemolysin activation secretion protein
ISU64_RS06690	COG3210	domain, Protein
ISU64_RS06730	COG3210	domain, Protein
ISU64_RS06740	COG3842	ATPase activity
ISU64_RS06750	COG1609	Transcriptional regulator
ISU64_RS06765	COG0395	ABC-type sugar transport system, permease component
ISU64_RS06770	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU64_RS06790	COG0668	transmembrane transport
ISU64_RS06795	COG1518	maintenance of DNA repeat elements
ISU64_RS06800	COG1203	CRISPR-associated helicase, Cas3
ISU64_RS06825	COG0667	Aldo Keto reductase
ISU64_RS06835	COG0477	Major facilitator Superfamily
ISU64_RS06845	COG0583	DNA-binding transcription factor activity
ISU64_RS06850	COG2771	luxR family
ISU64_RS06855	COG3916	Acyl-homoserine-lactone synthase
ISU64_RS06875	COG0628	permease
ISU64_RS06895	COG3328	transposase activity
ISU64_RS06915	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU64_RS06925	COG1530	ribonuclease E activity
ISU64_RS06930	COG0564	pseudouridine synthase activity
ISU64_RS06935	COG0424	maF-like protein
ISU64_RS06940	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU64_RS06945	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU64_RS06975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU64_RS06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU64_RS07000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU64_RS07010	COG0470	DNA polymerase III
ISU64_RS07015	COG0084	hydrolase, TatD family'
ISU64_RS07020	COG1263	PTS System
ISU64_RS07020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU64_RS07030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU64_RS07035	COG0537	adenosine 5'-monophosphoramidase activity
ISU64_RS07040	COG5633	Lipoprotein
ISU64_RS07055	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU64_RS07065	COG1252	NADH dehydrogenase
ISU64_RS07080	COG3328	transposase activity
ISU64_RS07085	COG3134	Outer membrane lipoprotein
ISU64_RS07090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU64_RS07095	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU64_RS07105	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU64_RS07110	COG1940	carbohydrate kinase activity
ISU64_RS07135	COG2850	peptidyl-arginine hydroxylation
ISU64_RS07145	COG0745	RESPONSE REGULATOR receiver
ISU64_RS07155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU64_RS07175	COG1187	pseudouridine synthase activity
ISU64_RS07180	COG0538	isocitrate dehydrogenase activity
ISU64_RS07195	COG0840	transmembrane signaling receptor activity
ISU64_RS07200	COG0702	epimerase
ISU64_RS07205	COG1733	regulation of RNA biosynthetic process
ISU64_RS07230	COG1522	sequence-specific DNA binding
ISU64_RS07240	COG0604	alcohol dehydrogenase
ISU64_RS07240	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS07240	COG3321	synthase
ISU64_RS07265	COG1285	pathogenesis
ISU64_RS07290	COG1360	Flagellar Motor Protein
ISU64_RS07295	COG0643	Histidine kinase
ISU64_RS07295	COG2198	Histidine kinase
ISU64_RS07300	COG0835	chemotaxis
ISU64_RS07305	COG2271	Major facilitator Superfamily
ISU64_RS07310	COG0251	oxidation-reduction process
ISU64_RS07320	COG2964	Protein conserved in bacteria
ISU64_RS07340	COG0840	transmembrane signaling receptor activity
ISU64_RS07345	COG0840	transmembrane signaling receptor activity
ISU64_RS07350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU64_RS07360	COG0745	RESPONSE REGULATOR receiver
ISU64_RS07365	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU64_RS07370	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU64_RS07380	COG5295	Hep Hag repeat protein
ISU64_RS07390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU64_RS07445	COG3121	Chaperone
ISU64_RS07465	COG3008	intermembrane lipid transfer
ISU64_RS07470	COG2995	paraquat-inducible protein a
ISU64_RS07475	COG1956	GAF domain-containing protein
ISU64_RS07485	COG0793	Belongs to the peptidase S41A family
ISU64_RS07495	COG3539	Fimbrial protein
ISU64_RS07500	COG3121	Chaperone
ISU64_RS07515	COG3121	Chaperone
ISU64_RS07520	COG2814	Major facilitator Superfamily
ISU64_RS07525	COG0823	Involved in the tonB-independent uptake of proteins
ISU64_RS07535	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU64_RS07540	COG1823	symporter activity
ISU64_RS07545	COG1988	membrane-bound metal-dependent
ISU64_RS07550	COG3328	transposase activity
ISU64_RS07555	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU64_RS07560	COG1653	transport
ISU64_RS07565	COG3842	ATPase activity
ISU64_RS07570	COG0395	ABC-type sugar transport system, permease component
ISU64_RS07575	COG1175	transmembrane transport
ISU64_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS07595	COG1917	Cupin 2, conserved barrel domain protein
ISU64_RS07600	COG3328	transposase activity
ISU64_RS07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU64_RS07615	COG3001	Fructosamine kinase
ISU64_RS07625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU64_RS07630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU64_RS07635	COG1121	(ABC) transporter
ISU64_RS07640	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU64_RS07660	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU64_RS07695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU64_RS07695	COG0072	phenylalanine-tRNA ligase activity
ISU64_RS07700	COG0776	regulation of translation
ISU64_RS07715	COG0386	Belongs to the glutathione peroxidase family
ISU64_RS07765	COG0791	NLP P60 protein
ISU64_RS07790	COG0574	Belongs to the PEP-utilizing enzyme family
ISU64_RS07790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU64_RS07800	COG0628	permease
ISU64_RS07805	COG0277	FAD linked oxidase domain protein
ISU64_RS07805	COG0247	lactate metabolic process
ISU64_RS07810	COG2050	protein possibly involved in aromatic compounds catabolism
ISU64_RS07815	COG0316	Belongs to the HesB IscA family
ISU64_RS07820	COG0719	Fe-S assembly protein
ISU64_RS07825	COG0396	ATPase activity
ISU64_RS07830	COG0719	Fe-S assembly protein
ISU64_RS07845	COG1388	LysM domain
ISU64_RS07845	COG1376	ErfK ybiS ycfS ynhG family protein
ISU64_RS07895	COG0307	riboflavin synthase, alpha
ISU64_RS07900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU64_RS07905	COG2814	Major facilitator Superfamily
ISU64_RS07910	COG0583	DNA-binding transcription factor activity
ISU64_RS07930	COG0791	NLP P60 protein
ISU64_RS07935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU64_RS07950	COG0346	lactoylglutathione lyase activity
ISU64_RS07960	COG3328	transposase activity
ISU64_RS07965	COG1902	pentaerythritol trinitrate reductase activity
ISU64_RS07970	COG1309	transcriptional regulator
ISU64_RS07975	COG2194	sulfuric ester hydrolase activity
ISU64_RS07980	COG3313	Fe-S protein
ISU64_RS07985	COG4989	oxidoreductase activity
ISU64_RS07995	COG3133	Outer membrane lipoprotein
ISU64_RS08005	COG3895	Periplasmic Protein
ISU64_RS08025	COG0625	glutathione transferase activity
ISU64_RS08040	COG3104	oligopeptide transport
ISU64_RS08045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU64_RS08045	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU64_RS08050	COG4172	Belongs to the ABC transporter superfamily
ISU64_RS08060	COG4171	peptide transport system, permease
ISU64_RS08065	COG4168	peptide transport system, permease
ISU64_RS08070	COG4166	transmembrane transport
ISU64_RS08085	COG5642	Protein of unknown function (DUF2384)
ISU64_RS08090	COG5654	RES domain protein
ISU64_RS08100	COG3106	COG3106 Predicted ATPase
ISU64_RS08110	COG1983	PspC domain protein
ISU64_RS08120	COG1842	Phage shock protein A
ISU64_RS08125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU64_RS08145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU64_RS08150	COG4948	Mandelate Racemase Muconate Lactonizing
ISU64_RS08155	COG2866	Carboxypeptidase
ISU64_RS08160	COG4166	transmembrane transport
ISU64_RS08175	COG0657	acetylesterase activity
ISU64_RS08185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU64_RS08185	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU64_RS08185	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU64_RS08185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU64_RS08195	COG1285	pathogenesis
ISU64_RS08200	COG3042	response to heat
ISU64_RS08205	COG3187	Heat shock protein
ISU64_RS08210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU64_RS08215	COG2911	Protein conserved in bacteria
ISU64_RS08225	COG3784	Protein of unknown function (DUF1318)
ISU64_RS08230	COG0246	Mannitol dehydrogenase
ISU64_RS08235	COG2390	Transcriptional regulator
ISU64_RS08245	COG1643	Atp-dependent helicase
ISU64_RS08260	COG3591	Belongs to the peptidase S1B family
ISU64_RS08270	COG3038	cytochrome b561
ISU64_RS08295	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU64_RS08300	COG2205	protein histidine kinase activity
ISU64_RS08305	COG0745	RESPONSE REGULATOR receiver
ISU64_RS08315	COG0531	amino acid
ISU64_RS08325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU64_RS08330	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU64_RS08335	COG0589	response to stress
ISU64_RS08340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU64_RS08345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU64_RS08360	COG1011	Hydrolase
ISU64_RS08365	COG0440	acetolactate synthase activity
ISU64_RS08370	COG0028	Belongs to the TPP enzyme family
ISU64_RS08400	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU64_RS08410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU64_RS08430	COG1609	Transcriptional regulator
ISU64_RS08440	COG0038	chloride channel
ISU64_RS08445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU64_RS08450	COG1940	carbohydrate kinase activity
ISU64_RS08455	COG0583	DNA-binding transcription factor activity
ISU64_RS08460	COG2814	Major facilitator Superfamily
ISU64_RS08470	COG0114	fumarate hydratase activity
ISU64_RS08480	COG5339	Protein conserved in bacteria
ISU64_RS08490	COG0385	Bile acid
ISU64_RS08495	COG0673	inositol 2-dehydrogenase activity
ISU64_RS08505	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS08515	COG1879	ABC-type sugar transport system periplasmic component
ISU64_RS08530	COG2274	protein secretion by the type I secretion system
ISU64_RS08535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU64_RS08545	COG1132	(ABC) transporter
ISU64_RS08575	COG2207	Transcriptional regulator
ISU64_RS08575	COG3708	Transcriptional regulator
ISU64_RS08580	COG4658	electron transport chain
ISU64_RS08585	COG4659	FMN binding
ISU64_RS08595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU64_RS08600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU64_RS08605	COG2271	Major facilitator Superfamily
ISU64_RS08615	COG1966	Carbon starvation protein
ISU64_RS08620	COG2879	small protein
ISU64_RS08625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU64_RS08645	COG0023	Translation Initiation Factor
ISU64_RS08660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU64_RS08665	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU64_RS08670	COG0671	phosphoesterase, PA-phosphatase related
ISU64_RS08680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISU64_RS08690	COG0583	DNA-binding transcription factor activity
ISU64_RS08715	COG0616	signal peptide processing
ISU64_RS08720	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS08730	COG1187	pseudouridine synthase activity
ISU64_RS08735	COG0009	L-threonylcarbamoyladenylate synthase
ISU64_RS08755	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU64_RS08765	COG0134	indole-3-glycerol-phosphate synthase activity
ISU64_RS08765	COG0135	phosphoribosylanthranilate isomerase activity
ISU64_RS08785	COG3047	cAMP biosynthetic process
ISU64_RS08820	COG3328	transposase activity
ISU64_RS08825	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU64_RS08830	COG2350	Protein conserved in bacteria
ISU64_RS08875	COG4608	Belongs to the ABC transporter superfamily
ISU64_RS08880	COG0444	Belongs to the ABC transporter superfamily
ISU64_RS08885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU64_RS08890	COG0601	transmembrane transport
ISU64_RS08900	COG2095	MarC family integral membrane protein
ISU64_RS08905	COG1012	belongs to the aldehyde dehydrogenase family
ISU64_RS08905	COG1454	alcohol dehydrogenase
ISU64_RS08920	COG3328	transposase activity
ISU64_RS08935	COG0788	formyltetrahydrofolate deformylase activity
ISU64_RS08945	COG0745	RESPONSE REGULATOR receiver
ISU64_RS08955	COG3328	transposase activity
ISU64_RS08960	COG0583	DNA-binding transcription factor activity
ISU64_RS08965	COG0708	Exodeoxyribonuclease III
ISU64_RS08970	COG0494	nUDIX hydrolase
ISU64_RS08980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU64_RS08990	COG0778	Nitroreductase
ISU64_RS08995	COG0616	signal peptide processing
ISU64_RS09000	COG0252	asparaginase activity
ISU64_RS09005	COG1335	isochorismatase
ISU64_RS09010	COG3139	Protein of unknown function (DUF1315)
ISU64_RS09030	COG3713	MltA-interacting MipA family protein
ISU64_RS09035	COG2766	serine protein kinase
ISU64_RS09050	COG0583	DNA-binding transcription factor activity
ISU64_RS09060	COG2814	Major facilitator Superfamily
ISU64_RS09070	COG2719	SpoVR family
ISU64_RS09100	COG1104	cysteine desulfurase activity
ISU64_RS09365	COG0582	viral genome integration into host DNA
ISU64_RS09375	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU64_RS09380	COG2951	lytic endotransglycosylase activity
ISU64_RS09395	COG2894	cell division
ISU64_RS09400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU64_RS09405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISU64_RS09410	COG0318	PFAM AMP-dependent synthetase and ligase
ISU64_RS09430	COG1199	ATP-dependent helicase activity
ISU64_RS09435	COG0251	oxidation-reduction process
ISU64_RS09450	COG0800	Aldolase
ISU64_RS09455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU64_RS09460	COG1737	Transcriptional regulator
ISU64_RS09465	COG0469	pyruvate kinase activity
ISU64_RS09475	COG1560	Kdo2-lipid A biosynthetic process
ISU64_RS09480	COG0739	heme binding
ISU64_RS09485	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU64_RS09495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU64_RS09520	COG0494	nUDIX hydrolase
ISU64_RS09530	COG1801	Protein of unknown function DUF72
ISU64_RS09535	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU64_RS09555	COG3102	Protein conserved in bacteria
ISU64_RS09575	COG0728	peptidoglycan biosynthetic process
ISU64_RS09585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU64_RS09600	COG3381	protein complex oligomerization
ISU64_RS09615	COG1940	carbohydrate kinase activity
ISU64_RS09620	COG0584	glycerophosphoryl diester phosphodiesterase
ISU64_RS09640	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU64_RS09645	COG3833	ABC-type maltose transport systems, permease component
ISU64_RS09665	COG0659	secondary active sulfate transmembrane transporter activity
ISU64_RS09685	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU64_RS09710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU64_RS09725	COG0012	GTP binding
ISU64_RS09790	COG5002	protein histidine kinase activity
ISU64_RS09835	COG0500	methyltransferase
ISU64_RS09855	COG3328	transposase activity
ISU64_RS09900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU64_RS09905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU64_RS09910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU64_RS09925	COG0402	S-adenosylhomocysteine deaminase activity
ISU64_RS09955	COG3328	transposase activity
ISU64_RS09990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU64_RS10000	COG3850	Histidine kinase
ISU64_RS10005	COG0387	Pfam Sodium calcium exchanger
ISU64_RS10010	COG1702	phosphate starvation-inducible protein PhoH
ISU64_RS10025	COG3658	cytochrome
ISU64_RS10030	COG1215	transferase activity, transferring glycosyl groups
ISU64_RS10035	COG0726	polysaccharide deacetylase
ISU64_RS10035	COG1649	PFAM Uncharacterised BCR, COG1649
ISU64_RS10040	COG0457	Tetratricopeptide repeat
ISU64_RS10045	COG0006	proline dipeptidase activity
ISU64_RS10065	COG1136	(ABC) transporter
ISU64_RS10065	COG0577	efflux transmembrane transporter activity
ISU64_RS10075	COG1136	(ABC) transporter
ISU64_RS10075	COG0577	efflux transmembrane transporter activity
ISU64_RS10105	COG2066	Belongs to the glutaminase family
ISU64_RS10115	COG1349	DNA-binding transcription factor activity
ISU64_RS10125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU64_RS10130	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU64_RS10145	COG2814	Major facilitator Superfamily
ISU64_RS10170	COG2030	dehydratase
ISU64_RS10175	COG0427	acetyl-CoA hydrolase
ISU64_RS10185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS10185	COG2205	protein histidine kinase activity
ISU64_RS10200	COG3188	usher protein
ISU64_RS10215	COG3328	transposase activity
ISU64_RS10230	COG0582	viral genome integration into host DNA
ISU64_RS10235	COG1169	isochorismate synthase
ISU64_RS10240	COG2814	Major facilitator Superfamily
ISU64_RS10245	COG1132	(ABC) transporter
ISU64_RS10260	COG2226	methyltransferase
ISU64_RS10260	COG3433	isochorismatase activity
ISU64_RS10260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU64_RS10280	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISU64_RS10285	COG4771	TonB-dependent receptor
ISU64_RS10345	COG1067	ATP-dependent peptidase activity
ISU64_RS10370	COG3070	regulator of competence-specific genes
ISU64_RS10375	COG1289	transmembrane transporter activity
ISU64_RS10380	COG3304	Inner membrane component domain
ISU64_RS10385	COG0210	DNA helicase
ISU64_RS10400	COG1832	CoA-binding protein
ISU64_RS10420	COG2920	part of a sulfur-relay system
ISU64_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS10455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU64_RS10460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU64_RS10465	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS10470	COG3425	synthase
ISU64_RS10480	COG1024	Enoyl-CoA hydratase
ISU64_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS10495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU64_RS10500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU64_RS10630	COG0488	(ABC) transporter
ISU64_RS10645	COG0303	'Molybdopterin
ISU64_RS10655	COG1136	(ABC) transporter
ISU64_RS10685	COG0583	DNA-binding transcription factor activity
ISU64_RS10690	COG0477	Major facilitator Superfamily
ISU64_RS10700	COG2311	Membrane
ISU64_RS10735	COG2949	membrane
ISU64_RS10750	COG1346	cytolysis
ISU64_RS10760	COG2814	Major facilitator Superfamily
ISU64_RS10790	COG0489	protein tyrosine kinase activity
ISU64_RS10805	COG2982	Protein involved in outer membrane biogenesis
ISU64_RS10810	COG1253	flavin adenine dinucleotide binding
ISU64_RS10815	COG4114	ferric iron reductase
ISU64_RS10820	COG0076	glutamate decarboxylase activity
ISU64_RS10825	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU64_RS10840	COG1120	ATPase activity
ISU64_RS10845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS10850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS10855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU64_RS10870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU64_RS10875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU64_RS10885	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU64_RS10885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU64_RS10905	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU64_RS10905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU64_RS10915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU64_RS10930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU64_RS10945	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS10950	COG1129	ABC transporter
ISU64_RS10955	COG1129	ABC transporter
ISU64_RS10960	COG0371	Dehydrogenase
ISU64_RS10965	COG0531	amino acid
ISU64_RS10975	COG2925	Exonuclease
ISU64_RS10990	COG3328	transposase activity
ISU64_RS11005	COG2271	Major facilitator Superfamily
ISU64_RS11010	COG3011	Protein conserved in bacteria
ISU64_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS11025	COG4948	Mandelate Racemase Muconate Lactonizing
ISU64_RS11040	COG0534	Mate efflux family protein
ISU64_RS11060	COG3122	Protein conserved in bacteria
ISU64_RS11085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU64_RS11105	COG2223	nitrite transmembrane transporter activity
ISU64_RS11140	COG1132	(ABC) transporter
ISU64_RS11150	COG2207	Transcriptional regulator
ISU64_RS11185	COG1113	amino acid transport
ISU64_RS11205	COG1496	oxidoreductase activity
ISU64_RS11210	COG2226	methyltransferase
ISU64_RS11220	COG5001	Diguanylate cyclase
ISU64_RS11220	COG5002	protein histidine kinase activity
ISU64_RS11220	COG3447	MASE1 domain protein
ISU64_RS11240	COG3716	PTS system mannose fructose sorbose family IID component
ISU64_RS11245	COG3715	PTS system
ISU64_RS11250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS11250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU64_RS11260	COG1846	Transcriptional regulator
ISU64_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
ISU64_RS11280	COG3384	dioxygenase
ISU64_RS11290	COG3971	2-oxopent-4-enoate hydratase activity
ISU64_RS11305	COG2368	4-hydroxyphenylacetate
ISU64_RS11310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU64_RS11315	COG1760	l-serine dehydratase
ISU64_RS11340	COG0513	Belongs to the DEAD box helicase family
ISU64_RS11345	COG3141	response to X-ray
ISU64_RS11360	COG1770	oligopeptidase
ISU64_RS11375	COG1528	Iron-storage protein
ISU64_RS11380	COG2372	response to copper ion
ISU64_RS11405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU64_RS11410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU64_RS11435	COG3418	PFAM FlgN family protein
ISU64_RS11440	COG2747	anti-sigma28 factor FlgM
ISU64_RS11450	COG1815	bacterial-type flagellum-dependent cell motility
ISU64_RS11455	COG1558	bacterial-type flagellum-dependent cell motility
ISU64_RS11495	COG1256	bacterial-type flagellum assembly
ISU64_RS11505	COG2390	Transcriptional regulator
ISU64_RS11510	COG3347	Dehydrogenase
ISU64_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS11515	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS11525	COG1129	ABC transporter
ISU64_RS11530	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS11535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU64_RS11555	COG1987	bacterial-type flagellum assembly
ISU64_RS11580	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU64_RS11595	COG1157	protein secretion by the type III secretion system
ISU64_RS11615	COG1677	Flagellar hook-basal body complex protein FliE
ISU64_RS11635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU64_RS11640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU64_RS11670	COG1191	sigma factor activity
ISU64_RS11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS11690	COG0765	amino acid transport
ISU64_RS11695	COG1126	abc transporter atp-binding protein
ISU64_RS11710	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU64_RS11710	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU64_RS11710	COG0506	proline dehydrogenase activity
ISU64_RS11725	COG0672	)-iron permease
ISU64_RS11730	COG2822	iron ion transport
ISU64_RS11750	COG1113	amino acid transport
ISU64_RS11770	COG3136	membrane protein required for alginate biosynthesis
ISU64_RS11780	COG2197	response regulator
ISU64_RS11900	COG2188	Transcriptional regulator
ISU64_RS11905	COG0673	inositol 2-dehydrogenase activity
ISU64_RS11915	COG1175	transmembrane transport
ISU64_RS11920	COG0395	ABC-type sugar transport system, permease component
ISU64_RS11925	COG3842	ATPase activity
ISU64_RS11970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU64_RS12005	COG3086	response to oxidative stress
ISU64_RS12010	COG3026	antisigma factor binding
ISU64_RS12025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU64_RS12035	COG0513	Belongs to the DEAD box helicase family
ISU64_RS12080	COG1984	allophanate hydrolase subunit 2
ISU64_RS12095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU64_RS12100	COG5212	phosphodiesterase
ISU64_RS12110	COG3272	Protein of unknown function (DUF1722)
ISU64_RS12145	COG2205	protein histidine kinase activity
ISU64_RS12150	COG0745	RESPONSE REGULATOR receiver
ISU64_RS12165	COG0033	Phosphoglucomutase
ISU64_RS12170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU64_RS12185	COG1917	Cupin 2, conserved barrel domain protein
ISU64_RS12185	COG2169	Transcriptional regulator
ISU64_RS12190	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU64_RS12195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU64_RS12200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU64_RS12210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU64_RS12220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU64_RS12230	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU64_RS12235	COG4413	Urea transporter
ISU64_RS12245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU64_RS12270	COG0831	urea catabolic process
ISU64_RS12275	COG1124	(ABC) transporter
ISU64_RS12280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU64_RS12285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU64_RS12295	COG0747	negative chemotaxis
ISU64_RS12300	COG1278	Cold shock
ISU64_RS12340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU64_RS12345	COG4175	Glycine betaine
ISU64_RS12350	COG4176	ABC-type proline glycine betaine transport system permease component
ISU64_RS12355	COG2113	Glycine betaine
ISU64_RS12375	COG1953	Uracil, thiamine, allantoin
ISU64_RS12395	COG2226	methyltransferase
ISU64_RS12405	COG1388	LysM domain
ISU64_RS12405	COG0741	lytic transglycosylase activity
ISU64_RS12420	COG0656	L-ascorbic acid biosynthetic process
ISU64_RS12450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU64_RS12460	COG2011	ABC-type metal ion transport system permease component
ISU64_RS12465	COG1464	Belongs to the NlpA lipoprotein family
ISU64_RS12475	COG1720	tRNA m6t6A37 methyltransferase activity
ISU64_RS12485	COG3015	lipoprotein NlpE involved in copper resistance
ISU64_RS12495	COG4681	YaeQ
ISU64_RS12505	COG4568	rho-dependent transcription termination
ISU64_RS12515	COG0037	tRNA processing
ISU64_RS12520	COG0346	lactoylglutathione lyase activity
ISU64_RS12530	COG0587	DNA-directed DNA polymerase activity
ISU64_RS12555	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU64_RS12570	COG0750	zinc metalloprotease
ISU64_RS12575	COG0575	Belongs to the CDS family
ISU64_RS12635	COG0564	pseudouridine synthase activity
ISU64_RS12640	COG3098	single-species biofilm formation
ISU64_RS12660	COG1611	Belongs to the LOG family
ISU64_RS12675	COG2363	Small membrane protein
ISU64_RS12680	COG0583	DNA-binding transcription factor activity
ISU64_RS12690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU64_RS12695	COG2166	iron-sulfur cluster assembly
ISU64_RS12700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU64_RS12705	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU64_RS12720	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU64_RS12760	COG0288	reversible hydration of carbon dioxide
ISU64_RS12780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU64_RS12800	COG2165	general secretion pathway protein
ISU64_RS12840	COG3328	transposase activity
ISU64_RS12855	COG0840	transmembrane signaling receptor activity
ISU64_RS12870	COG0583	DNA-binding transcription factor activity
ISU64_RS12875	COG2814	Major facilitator Superfamily
ISU64_RS12880	COG0583	DNA-binding transcription factor activity
ISU64_RS12890	COG1609	Transcriptional regulator
ISU64_RS12970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU64_RS12980	COG1074	ATP-dependent DNA helicase activity
ISU64_RS12985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU64_RS13010	COG3119	arylsulfatase activity
ISU64_RS13015	COG1349	DNA-binding transcription factor activity
ISU64_RS13025	COG2222	sugar isomerase
ISU64_RS13030	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU64_RS13035	COG3715	PTS system
ISU64_RS13040	COG3716	PTS system mannose fructose sorbose family IID component
ISU64_RS13045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS13055	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS13065	COG0641	radical SAM
ISU64_RS13070	COG3119	arylsulfatase activity
ISU64_RS13095	COG2271	Major facilitator Superfamily
ISU64_RS13115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU64_RS13115	COG1263	PTS System
ISU64_RS13120	COG1874	Beta-galactosidase
ISU64_RS13125	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU64_RS13130	COG3833	ABC-type maltose transport systems, permease component
ISU64_RS13135	COG1175	transmembrane transport
ISU64_RS13140	COG2182	Extracellular solute-binding protein
ISU64_RS13150	COG1129	ABC transporter
ISU64_RS13155	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS13160	COG1879	ABC-type sugar transport system periplasmic component
ISU64_RS13170	COG0791	NLP P60 protein
ISU64_RS13175	COG1695	Transcriptional regulator
ISU64_RS13225	COG3328	transposase activity
ISU64_RS13270	COG2944	sequence-specific DNA binding
ISU64_RS13295	COG0582	viral genome integration into host DNA
ISU64_RS13315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU64_RS13320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU64_RS13325	COG4974	Belongs to the 'phage' integrase family
ISU64_RS13330	COG0716	FMN binding
ISU64_RS13335	COG4452	Inner membrane protein CreD
ISU64_RS13340	COG2205	protein histidine kinase activity
ISU64_RS13345	COG0745	RESPONSE REGULATOR receiver
ISU64_RS13370	COG1272	protein, Hemolysin III
ISU64_RS13415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU64_RS13420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU64_RS13425	COG0006	proline dipeptidase activity
ISU64_RS13445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU64_RS13460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU64_RS13495	COG0191	fructose-bisphosphate aldolase activity
ISU64_RS13515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU64_RS13520	COG0501	Belongs to the peptidase M48B family
ISU64_RS13535	COG1166	arginine decarboxylase activity
ISU64_RS13550	COG2356	endonuclease I
ISU64_RS13555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU64_RS13560	COG0189	ligase activity
ISU64_RS13575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU64_RS13585	COG2805	Type II/IV secretion system protein
ISU64_RS13590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU64_RS13595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU64_RS13600	COG0762	integral membrane protein
ISU64_RS13610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU64_RS13615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU64_RS13620	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU64_RS13620	COG3064	Membrane
ISU64_RS13620	COG1073	alpha beta
ISU64_RS13640	COG3171	Protein conserved in bacteria
ISU64_RS13650	COG1194	a g-specific adenine glycosylase
ISU64_RS13670	COG4774	siderophore transport
ISU64_RS13675	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS13680	COG1129	ABC transporter
ISU64_RS13685	COG1879	ABC-type sugar transport system periplasmic component
ISU64_RS13690	COG1982	Orn Lys Arg decarboxylase major
ISU64_RS13780	COG3916	Acyl-homoserine-lactone synthase
ISU64_RS13785	COG2771	luxR family
ISU64_RS13835	COG2211	Major facilitator Superfamily
ISU64_RS13850	COG3133	Outer membrane lipoprotein
ISU64_RS13875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ISU64_RS13880	COG1191	sigma factor activity
ISU64_RS13905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ISU64_RS13925	COG3710	Transcriptional regulator
ISU64_RS13945	COG1256	bacterial-type flagellum assembly
ISU64_RS13955	COG1706	bacterial-type flagellum-dependent cell motility
ISU64_RS13965	COG4786	Flagellar basal body rod
ISU64_RS13970	COG4787	bacterial-type flagellum-dependent cell motility
ISU64_RS13975	COG1749	Flagellar hook protein flgE
ISU64_RS13980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU64_RS13985	COG1558	bacterial-type flagellum-dependent cell motility
ISU64_RS13990	COG1815	bacterial-type flagellum-dependent cell motility
ISU64_RS13995	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU64_RS14035	COG1677	Flagellar hook-basal body complex protein FliE
ISU64_RS14060	COG1987	bacterial-type flagellum assembly
ISU64_RS14065	COG1684	flagellar biosynthetic protein fliR
ISU64_RS14070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU64_RS14090	COG4592	Periplasmic binding protein
ISU64_RS14130	COG4964	Belongs to the GSP D family
ISU64_RS14135	COG4964	Belongs to the GSP D family
ISU64_RS14185	COG0848	biopolymer transport protein
ISU64_RS14190	COG0811	peptide transport
ISU64_RS14195	COG0626	cystathionine gamma-synthase activity
ISU64_RS14200	COG0586	Pfam SNARE associated Golgi protein
ISU64_RS14205	COG2207	Transcriptional regulator
ISU64_RS14210	COG1979	alcohol dehydrogenase
ISU64_RS14220	COG0656	L-ascorbic acid biosynthetic process
ISU64_RS14230	COG2132	Multicopper oxidase
ISU64_RS14240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU64_RS14250	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU64_RS14255	COG0583	DNA-binding transcription factor activity
ISU64_RS14265	COG3150	esterase
ISU64_RS14270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU64_RS14275	COG3151	Protein conserved in bacteria
ISU64_RS14280	COG0494	nUDIX hydrolase
ISU64_RS14285	COG1538	Outer membrane efflux protein
ISU64_RS14295	COG0754	glutathionylspermidine amidase activity
ISU64_RS14300	COG3384	dioxygenase
ISU64_RS14320	COG0531	amino acid
ISU64_RS14335	COG3025	triphosphatase activity
ISU64_RS14340	COG4991	sh3 domain protein
ISU64_RS14355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU64_RS14370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU64_RS14375	COG0358	DNA primase activity
ISU64_RS14455	COG0251	oxidation-reduction process
ISU64_RS14475	COG0436	Aminotransferase
ISU64_RS14495	COG1289	transmembrane transporter activity
ISU64_RS14515	COG0395	ABC-type sugar transport system, permease component
ISU64_RS14525	COG2182	Extracellular solute-binding protein
ISU64_RS14530	COG1609	Transcriptional regulator
ISU64_RS14535	COG3459	Glycosyltransferase 36 associated
ISU64_RS14540	COG3842	ATPase activity
ISU64_RS14560	COG3210	domain, Protein
ISU64_RS14565	COG3210	domain, Protein
ISU64_RS14595	COG3210	domain, Protein
ISU64_RS14600	COG2831	hemolysin activation secretion protein
ISU64_RS14605	COG4245	von Willebrand factor, type A
ISU64_RS14635	COG3247	response to pH
ISU64_RS14640	COG1902	pentaerythritol trinitrate reductase activity
ISU64_RS14640	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU64_RS14655	COG1451	nucleotide metabolic process
ISU64_RS14660	COG0673	inositol 2-dehydrogenase activity
ISU64_RS14680	COG2721	sulfolactate sulfo-lyase activity
ISU64_RS14695	COG2271	Major facilitator Superfamily
ISU64_RS14710	COG0586	Pfam SNARE associated Golgi protein
ISU64_RS14725	COG4575	ribosome binding
ISU64_RS14730	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU64_RS14740	COG2259	Doxx family
ISU64_RS14745	COG0435	Glutathione S-transferase
ISU64_RS14750	COG0583	DNA-binding transcription factor activity
ISU64_RS14755	COG1741	Belongs to the pirin family
ISU64_RS14765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU64_RS14785	COG2823	Periplasmic or secreted lipoprotein
ISU64_RS14795	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU64_RS14800	COG0784	Response regulator, receiver
ISU64_RS14800	COG5002	protein histidine kinase activity
ISU64_RS14800	COG2198	Histidine kinase
ISU64_RS14805	COG1242	4 iron, 4 sulfur cluster binding
ISU64_RS14810	COG0067	glutamate synthase
ISU64_RS14810	COG0069	glutamate synthase activity
ISU64_RS14810	COG0070	glutamate synthase
ISU64_RS14815	COG0493	'glutamate synthase
ISU64_RS14825	COG2969	positive regulation of protein catabolic process
ISU64_RS14830	COG0625	glutathione transferase activity
ISU64_RS14850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU64_RS14855	COG3105	Protein conserved in bacteria
ISU64_RS14860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU64_RS14870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU64_RS14880	COG5007	Belongs to the BolA IbaG family
ISU64_RS14885	COG3113	response to antibiotic
ISU64_RS14890	COG2854	intermembrane phospholipid transfer
ISU64_RS14895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU64_RS14900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU64_RS14905	COG1127	ABC transporter
ISU64_RS14910	COG0530	calcium, potassium:sodium antiporter activity
ISU64_RS14915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU64_RS14915	COG0517	IMP dehydrogenase activity
ISU64_RS14920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU64_RS14925	COG3117	lipopolysaccharide transmembrane transporter activity
ISU64_RS14930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU64_RS14935	COG1137	ATPase activity
ISU64_RS14940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU64_RS14960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS14985	COG1609	Transcriptional regulator
ISU64_RS14990	COG1263	PTS System
ISU64_RS14990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU64_RS14995	COG0366	Alpha amylase catalytic
ISU64_RS15000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU64_RS15005	COG3783	Cytochrome b(562)
ISU64_RS15015	COG0312	modulator of DNA gyrase
ISU64_RS15025	COG2732	(Barnase) inhibitor
ISU64_RS15055	COG0583	DNA-binding transcription factor activity
ISU64_RS15105	COG0312	modulator of DNA gyrase
ISU64_RS15110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU64_RS15115	COG3164	Protein of unknown function
ISU64_RS15120	COG1530	ribonuclease E activity
ISU64_RS15125	COG0424	maF-like protein
ISU64_RS15130	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU64_RS15135	COG1792	Involved in formation and maintenance of cell shape
ISU64_RS15140	COG1077	Cell shape determining protein MreB Mrl
ISU64_RS15145	COG2200	EAL domain
ISU64_RS15145	COG2199	diguanylate cyclase activity
ISU64_RS15150	COG0604	alcohol dehydrogenase
ISU64_RS15155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU64_RS15170	COG0511	ligase activity, forming carbon-carbon bonds
ISU64_RS15175	COG0439	Biotin carboxylase
ISU64_RS15185	COG3924	membrane
ISU64_RS15190	COG4145	pantothenate transmembrane transporter activity
ISU64_RS15200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU64_RS15205	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU64_RS15235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU64_RS15245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU64_RS15250	COG3133	Outer membrane lipoprotein
ISU64_RS15255	COG1278	Cold shock
ISU64_RS15260	COG1278	Cold shock
ISU64_RS15280	COG0625	glutathione transferase activity
ISU64_RS15290	COG1069	ribulokinase activity
ISU64_RS15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS15305	COG1129	ABC transporter
ISU64_RS15315	COG1560	Kdo2-lipid A biosynthetic process
ISU64_RS15325	COG0025	NhaP-type Na H and K H
ISU64_RS15330	COG2252	PERMEase
ISU64_RS15335	COG3077	Addiction module antitoxin, RelB DinJ family
ISU64_RS15350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU64_RS15360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU64_RS15365	COG0431	NADPH-dependent FMN reductase
ISU64_RS15370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU64_RS15375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU64_RS15380	COG1869	D-ribose catabolic process
ISU64_RS15385	COG1917	Cupin 2, conserved barrel domain protein
ISU64_RS15385	COG2207	Transcriptional regulator
ISU64_RS15390	COG0673	inositol 2-dehydrogenase activity
ISU64_RS15410	COG3209	COG3209 Rhs family protein
ISU64_RS15420	COG3501	Rhs element vgr protein
ISU64_RS15465	COG3501	Rhs element vgr protein
ISU64_RS15595	COG1175	transmembrane transport
ISU64_RS15600	COG3833	ABC-type maltose transport systems, permease component
ISU64_RS15615	COG0527	aspartate kinase activity
ISU64_RS15635	COG1414	Transcriptional regulator
ISU64_RS15645	COG2224	Isocitrate lyase
ISU64_RS15650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU64_RS15695	COG0542	response to heat
ISU64_RS15705	COG0564	pseudouridine synthase activity
ISU64_RS15710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU64_RS15715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU64_RS15725	COG0077	Prephenate dehydratase
ISU64_RS15725	COG1605	Chorismate mutase
ISU64_RS15730	COG1605	Chorismate mutase
ISU64_RS15730	COG0287	Prephenate dehydrogenase
ISU64_RS15755	COG3279	Response regulator of the LytR AlgR family
ISU64_RS15765	COG3137	Salt-induced outer membrane protein
ISU64_RS15790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU64_RS15795	COG4137	Cytochrome C assembly protein
ISU64_RS15800	COG4536	flavin adenine dinucleotide binding
ISU64_RS15810	COG2918	glutathione biosynthetic process
ISU64_RS15815	COG1238	metal cluster binding
ISU64_RS15820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU64_RS15845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU64_RS15885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU64_RS15890	COG3958	Transketolase
ISU64_RS15895	COG3959	Transketolase, thiamine diphosphate binding domain
ISU64_RS15900	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS15905	COG1129	ABC transporter
ISU64_RS15915	COG1879	ABC-type sugar transport system periplasmic component
ISU64_RS15925	COG3783	Cytochrome b(562)
ISU64_RS15930	COG3038	cytochrome b561
ISU64_RS15935	COG3381	protein complex oligomerization
ISU64_RS15940	COG3302	dmso reductase anchor subunit
ISU64_RS15945	COG0437	4 iron, 4 sulfur cluster binding
ISU64_RS15950	COG0243	molybdopterin cofactor binding
ISU64_RS15955	COG0235	Class ii aldolase
ISU64_RS15960	COG1349	DNA-binding transcription factor activity
ISU64_RS15970	COG1129	ABC transporter
ISU64_RS15975	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS15980	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS15985	COG3623	hexulose-6-phosphate isomerase
ISU64_RS15990	COG1070	Carbohydrate kinase
ISU64_RS15995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU64_RS15995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU64_RS16005	COG0024	Methionine aminopeptidase
ISU64_RS16015	COG4771	TonB-dependent receptor
ISU64_RS16025	COG1858	cytochrome C peroxidase
ISU64_RS16030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS16050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU64_RS16065	COG2376	Dihydroxyacetone kinase
ISU64_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
ISU64_RS16075	COG1063	alcohol dehydrogenase
ISU64_RS16080	COG0698	ribose 5-phosphate isomerase
ISU64_RS16090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU64_RS16095	COG1388	LysM domain
ISU64_RS16095	COG4942	peptidase
ISU64_RS16135	COG0529	Catalyzes the synthesis of activated sulfate
ISU64_RS16190	COG0720	synthase
ISU64_RS16195	COG0602	queuosine metabolic process
ISU64_RS16215	COG3956	TIGRFAM MazG family protein
ISU64_RS16220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU64_RS16225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU64_RS16235	COG2205	protein histidine kinase activity
ISU64_RS16235	COG3850	Histidine kinase
ISU64_RS16235	COG4999	Histidine kinase
ISU64_RS16235	COG3437	response regulator, receiver
ISU64_RS16240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU64_RS16265	COG3328	transposase activity
ISU64_RS16290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU64_RS16295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU64_RS16300	COG1120	ATPase activity
ISU64_RS16305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU64_RS16310	COG1643	Atp-dependent helicase
ISU64_RS16315	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU64_RS16330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU64_RS16335	COG0617	tRNA 3'-terminal CCA addition
ISU64_RS16340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU64_RS16365	COG0842	Transport permease protein
ISU64_RS16370	COG1131	(ABC) transporter
ISU64_RS16375	COG0288	reversible hydration of carbon dioxide
ISU64_RS16380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU64_RS16385	COG2132	Multicopper oxidase
ISU64_RS16405	COG0697	spore germination
ISU64_RS16415	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU64_RS16425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU64_RS16430	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU64_RS16435	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU64_RS16440	COG2186	Transcriptional regulator
ISU64_RS16445	COG1113	amino acid transport
ISU64_RS16450	COG3725	Membrane protein required for beta-lactamase induction
ISU64_RS16455	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU64_RS16465	COG4969	Belongs to the N-Me-Phe pilin family
ISU64_RS16470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU64_RS16475	COG1459	type II secretion system
ISU64_RS16515	COG0494	nUDIX hydrolase
ISU64_RS16545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU64_RS16550	COG0849	cell division
ISU64_RS16555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU64_RS16575	COG0772	Belongs to the SEDS family
ISU64_RS16590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU64_RS16595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU64_RS16600	COG0768	penicillin binding
ISU64_RS16605	COG3116	cell division
ISU64_RS16630	COG1609	Transcriptional regulator
ISU64_RS16645	COG0028	Belongs to the TPP enzyme family
ISU64_RS16650	COG1022	Amp-dependent synthetase and ligase
ISU64_RS16675	COG0473	3-isopropylmalate dehydrogenase activity
ISU64_RS16690	COG2814	Major facilitator Superfamily
ISU64_RS16700	COG4143	(ABC) transporter
ISU64_RS16705	COG1178	ABC-type Fe3 transport system permease component
ISU64_RS16710	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU64_RS16715	COG0586	Pfam SNARE associated Golgi protein
ISU64_RS16720	COG0417	DNA replication proofreading
ISU64_RS16740	COG3047	cAMP biosynthetic process
ISU64_RS16740	COG2885	chlorophyll binding
ISU64_RS16825	COG0564	pseudouridine synthase activity
ISU64_RS16830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU64_RS16880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU64_RS16890	COG2966	Psort location CytoplasmicMembrane, score
ISU64_RS16895	COG1280	lysine exporter protein (LysE YggA)
ISU64_RS16900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU64_RS16920	COG1047	Peptidyl-prolyl cis-trans
ISU64_RS16935	COG0196	riboflavin kinase activity
ISU64_RS16945	COG0583	DNA-binding transcription factor activity
ISU64_RS16965	COG1584	GPR1 FUN34 yaaH family protein
ISU64_RS16980	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU64_RS17020	COG0745	RESPONSE REGULATOR receiver
ISU64_RS17025	COG3045	CreA protein
ISU64_RS17030	COG2207	Transcriptional regulator
ISU64_RS17030	COG3708	Transcriptional regulator
ISU64_RS17045	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU64_RS17050	COG0741	lytic transglycosylase activity
ISU64_RS17065	COG2199	diguanylate cyclase activity
ISU64_RS17070	COG2885	chlorophyll binding
ISU64_RS17075	COG0488	(ABC) transporter
ISU64_RS17095	COG0560	Phosphoserine phosphatase
ISU64_RS17100	COG3726	membrane protein affecting hemolysin expression
ISU64_RS17125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU64_RS17130	COG0084	hydrolase, TatD family'
ISU64_RS17135	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU64_RS17145	COG2823	Periplasmic or secreted lipoprotein
ISU64_RS17155	COG0456	acetyltransferase
ISU64_RS17160	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU64_RS17200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU64_RS17205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU64_RS17220	COG0859	PFAM glycosyl transferase family 9
ISU64_RS17230	COG2390	Transcriptional regulator
ISU64_RS17270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU64_RS17270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS17270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS17275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU64_RS17280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU64_RS17285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU64_RS17290	COG2207	Transcriptional regulator
ISU64_RS17300	COG4269	membrane
ISU64_RS17355	COG1401	restriction endodeoxyribonuclease activity
ISU64_RS17370	COG2194	sulfuric ester hydrolase activity
ISU64_RS17375	COG2197	response regulator
ISU64_RS17380	COG3851	Histidine kinase
ISU64_RS17385	COG2271	Major facilitator Superfamily
ISU64_RS17400	COG2831	hemolysin activation secretion protein
ISU64_RS17405	COG0747	negative chemotaxis
ISU64_RS17410	COG0601	transmembrane transport
ISU64_RS17415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU64_RS17420	COG0444	Belongs to the ABC transporter superfamily
ISU64_RS17425	COG4608	Belongs to the ABC transporter superfamily
ISU64_RS17430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU64_RS17435	COG2199	diguanylate cyclase activity
ISU64_RS17435	COG2200	EAL domain
ISU64_RS17440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU64_RS17460	COG0612	Peptidase, M16
ISU64_RS17465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU64_RS17470	COG1942	4-Oxalocrotonate Tautomerase
ISU64_RS17475	COG2200	EAL domain
ISU64_RS17480	COG2982	Protein involved in outer membrane biogenesis
ISU64_RS17485	COG2134	cdp-diacylglycerol pyrophosphatase
ISU64_RS17490	COG1295	ribonuclease BN
ISU64_RS17515	COG1929	Belongs to the glycerate kinase type-1 family
ISU64_RS17520	COG2610	gluconate transmembrane transporter activity
ISU64_RS17530	COG3835	regulator
ISU64_RS17535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU64_RS17540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU64_RS17545	COG0339	signal peptide processing
ISU64_RS17565	COG0589	response to stress
ISU64_RS17580	COG0306	phosphate transporter
ISU64_RS17600	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS17615	COG0191	fructose-bisphosphate aldolase activity
ISU64_RS17635	COG1741	Belongs to the pirin family
ISU64_RS17640	COG1609	Transcriptional regulator
ISU64_RS17645	COG2610	gluconate transmembrane transporter activity
ISU64_RS17650	COG3265	gluconokinase activity
ISU64_RS17665	COG2095	MarC family integral membrane protein
ISU64_RS17670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU64_RS17705	COG3275	phosphorelay sensor kinase activity
ISU64_RS17730	COG0058	SHG alpha-glucan phosphorylase activity
ISU64_RS17735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU64_RS17760	COG2423	ornithine cyclodeaminase activity
ISU64_RS17765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU64_RS17775	COG5645	(Lipo)protein
ISU64_RS17795	COG3977	Valine--pyruvate aminotransferase
ISU64_RS17805	COG0366	Alpha amylase catalytic
ISU64_RS17820	COG2885	chlorophyll binding
ISU64_RS17830	COG2818	Glycosylase
ISU64_RS17860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU64_RS17860	COG2213	PTS system mannitol-specific
ISU64_RS17870	COG3722	fumarate hydratase activity
ISU64_RS17895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU64_RS17910	COG0437	4 iron, 4 sulfur cluster binding
ISU64_RS17915	COG2864	formate dehydrogenase
ISU64_RS17930	COG3276	selenocysteine insertion sequence binding
ISU64_RS17985	COG0513	Belongs to the DEAD box helicase family
ISU64_RS18005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU64_RS18015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU64_RS18025	COG0826	peptidase U32
ISU64_RS18030	COG0826	peptidase U32
ISU64_RS18035	COG3154	lipid carrier protein
ISU64_RS18040	COG3153	acetyltransferase
ISU64_RS18060	COG1653	transport
ISU64_RS18065	COG1175	transmembrane transport
ISU64_RS18070	COG0395	ABC-type sugar transport system, permease component
ISU64_RS18075	COG3842	ATPase activity
ISU64_RS18090	COG0702	epimerase
ISU64_RS18095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU64_RS18100	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU64_RS18105	COG3454	Phosphonate metabolism
ISU64_RS18110	COG4778	phosphonate C-P lyase system protein PhnL
ISU64_RS18115	COG4107	phosphonate C-P lyase system protein PhnK
ISU64_RS18120	COG3627	carbon phosphorus lyase activity
ISU64_RS18125	COG3626	phosphonate metabolism
ISU64_RS18130	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU64_RS18135	COG3624	Phosphonate C-P lyase system protein PhnG
ISU64_RS18140	COG2188	Transcriptional regulator
ISU64_RS18155	COG4608	Belongs to the ABC transporter superfamily
ISU64_RS18160	COG0444	Belongs to the ABC transporter superfamily
ISU64_RS18165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU64_RS18170	COG0601	transmembrane transport
ISU64_RS18180	COG2731	YhcH YjgK YiaL family protein
ISU64_RS18190	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU64_RS18200	COG0525	valine-tRNA ligase activity
ISU64_RS18205	COG2927	DNA polymerase III (CHI subunit)
ISU64_RS18215	COG0795	lipopolysaccharide-transporting ATPase activity
ISU64_RS18220	COG0795	lipopolysaccharide-transporting ATPase activity
ISU64_RS18230	COG0582	viral genome integration into host DNA
ISU64_RS18270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU64_RS18300	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU64_RS18305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU64_RS18310	COG1739	Uncharacterized protein family UPF0029
ISU64_RS18335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU64_RS18355	COG0805	protein transport
ISU64_RS18365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU64_RS18385	COG1322	Protein conserved in bacteria
ISU64_RS18390	COG0586	Pfam SNARE associated Golgi protein
ISU64_RS18395	COG1966	Carbon starvation protein
ISU64_RS18410	COG0412	Dienelactone hydrolase
ISU64_RS18420	COG0583	DNA-binding transcription factor activity
ISU64_RS18425	COG0697	spore germination
ISU64_RS18430	COG0679	Auxin Efflux Carrier
ISU64_RS18435	COG0584	glycerophosphoryl diester phosphodiesterase
ISU64_RS18495	COG0410	ABC transporter
ISU64_RS18505	COG4177	L-phenylalanine transmembrane transporter activity
ISU64_RS18515	COG0683	leucine binding
ISU64_RS18535	COG2177	Part of the ABC transporter FtsEX involved in
ISU64_RS18540	COG2884	Cell division ATP-binding protein ftsE
ISU64_RS18545	COG0552	protein localization to endoplasmic reticulum
ISU64_RS18545	COG0552	protein localization to endoplasmic reticulum
ISU64_RS18550	COG0742	ribosomal rna small subunit methyltransferase
ISU64_RS18555	COG3776	membrane
ISU64_RS18570	COG3714	YhhN family
ISU64_RS18585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU64_RS18595	COG0247	lactate metabolic process
ISU64_RS18605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU64_RS18620	COG0561	phosphatase activity
ISU64_RS18625	COG2267	carboxylic ester hydrolase activity
ISU64_RS18630	COG1280	lysine exporter protein (LysE YggA)
ISU64_RS18635	COG1280	lysine exporter protein (LysE YggA)
ISU64_RS18640	COG0514	ATP-dependent DNA helicase (RecQ)
ISU64_RS18645	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU64_RS18650	COG2050	protein possibly involved in aromatic compounds catabolism
ISU64_RS18665	COG5564	TIM-barrel signal transduction protein
ISU64_RS18670	COG5441	Belongs to the UPF0261 family
ISU64_RS18680	COG0210	DNA helicase
ISU64_RS18685	COG1011	Hydrolase
ISU64_RS18690	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU64_RS18695	COG3159	Protein conserved in bacteria
ISU64_RS18715	COG3072	Adenylate cyclase
ISU64_RS18730	COG1587	Uroporphyrinogen-III synthase
ISU64_RS18735	COG2959	enzyme of heme biosynthesis
ISU64_RS18740	COG3071	HemY protein
ISU64_RS18770	COG1113	amino acid transport
ISU64_RS18790	COG2244	polysaccharide biosynthetic process
ISU64_RS18795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU64_RS18800	COG0456	acetyltransferase
ISU64_RS18805	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU64_RS18810	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU64_RS18815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU64_RS18820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU64_RS18825	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU64_RS18830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU64_RS18835	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU64_RS18840	COG3118	belongs to the thioredoxin family
ISU64_RS18865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU64_RS18880	COG3121	Chaperone
ISU64_RS18895	COG3121	Chaperone
ISU64_RS18910	COG3328	transposase activity
ISU64_RS18935	COG0583	DNA-binding transcription factor activity
ISU64_RS18980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU64_RS18985	COG3978	acetolactate synthase activity
ISU64_RS19005	COG3085	chromosome segregation
ISU64_RS19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS19020	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU64_RS19025	COG1129	ABC transporter
ISU64_RS19030	COG1879	ABC-type sugar transport system periplasmic component
ISU64_RS19075	COG0151	Belongs to the GarS family
ISU64_RS19095	COG1515	deoxyribonuclease V activity
ISU64_RS19130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU64_RS19180	COG0250	Participates in transcription elongation, termination and antitermination
ISU64_RS19235	COG2986	histidine ammonia-lyase
ISU64_RS19265	COG4607	ABC-type enterochelin transport system periplasmic component
ISU64_RS19275	COG4605	iron ion homeostasis
ISU64_RS19280	COG4604	ABC transporter, ATP-binding protein
ISU64_RS19325	COG0582	viral genome integration into host DNA
ISU64_RS19335	COG2207	Transcriptional regulator
ISU64_RS19335	COG1609	Transcriptional regulator
ISU64_RS19340	COG4214	carbohydrate transport
ISU64_RS19350	COG4213	ABC transporter substrate-binding protein
ISU64_RS19360	COG1070	Carbohydrate kinase
ISU64_RS19370	COG3121	Chaperone
ISU64_RS19385	COG3274	enterobacterial common antigen metabolic process
ISU64_RS19405	COG0460	homoserine dehydrogenase
ISU64_RS19405	COG0527	aspartate kinase activity
ISU64_RS19410	COG0626	cystathionine gamma-synthase activity
ISU64_RS19420	COG4682	membrane
ISU64_RS19430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU64_RS19435	COG1609	Transcriptional regulator
ISU64_RS19440	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU64_RS19455	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU64_RS19495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU64_RS19500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU64_RS19505	COG1494	fructose-1,6-bisphosphatase
ISU64_RS19515	COG3152	Membrane
ISU64_RS19530	COG0583	DNA-binding transcription factor activity
ISU64_RS19535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU64_RS19540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU64_RS19545	COG0471	metal ion transport
ISU64_RS19555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU64_RS19580	COG3678	ATP-independent chaperone mediated protein folding
ISU64_RS19585	COG0745	RESPONSE REGULATOR receiver
ISU64_RS19590	COG2205	protein histidine kinase activity
ISU64_RS19595	COG2169	Transcriptional regulator
ISU64_RS19595	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU64_RS19600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU64_RS19605	COG1045	serine acetyltransferase
ISU64_RS19620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU64_RS19625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU64_RS19635	COG4942	peptidase
ISU64_RS19650	COG0156	8-amino-7-oxononanoate synthase activity
ISU64_RS19660	COG0859	PFAM glycosyl transferase family 9
ISU64_RS19665	COG0859	PFAM glycosyl transferase family 9
ISU64_RS19670	COG1519	Transferase
ISU64_RS19705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU64_RS19730	COG1561	YicC-like family, N-terminal region
ISU64_RS19735	COG2860	membrane
ISU64_RS19755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU64_RS19760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU64_RS19765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU64_RS19775	COG0786	glutamate:sodium symporter activity
ISU64_RS19780	COG2233	PERMEase
ISU64_RS19785	COG2982	Protein involved in outer membrane biogenesis
ISU64_RS19790	COG0456	acetyltransferase
ISU64_RS19815	COG1011	Hydrolase
ISU64_RS19825	COG0174	glutamine synthetase
ISU64_RS19835	COG3852	Histidine kinase
ISU64_RS19845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU64_RS19860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU64_RS19860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU64_RS19865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU64_RS19870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU64_RS19875	COG3084	Protein conserved in bacteria
ISU64_RS19885	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU64_RS19890	COG3328	transposase activity
ISU64_RS19915	COG2186	Transcriptional regulator
ISU64_RS19920	COG0477	Major facilitator Superfamily
ISU64_RS19965	COG1522	sequence-specific DNA binding
ISU64_RS19970	COG0716	FMN binding
ISU64_RS19985	COG3312	ion transport
ISU64_RS20040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU64_RS20045	COG0573	inorganic phosphate transmembrane transporter activity
ISU64_RS20050	COG0581	inorganic phosphate transmembrane transporter activity
ISU64_RS20060	COG0704	Plays a role in the regulation of phosphate uptake
ISU64_RS20070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU64_RS20075	COG0765	amino acid transport
ISU64_RS20080	COG0765	amino acid transport
ISU64_RS20085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU64_RS20125	COG0706	membrane insertase activity
ISU64_RS20140	COG0230	Belongs to the bacterial ribosomal protein bL34 family