locus-tag	class	description
YOP2083	COG0582	viral genome integration into host DNA
YP02742	COG4235	cytochrome complex assembly
YP02742	COG3088	subunit of a heme lyase
YPCD1.16c	COG0477	Major facilitator Superfamily
YPCD1.57	COG0456	acetyltransferase
YPCD1.65	COG0786	glutamate:sodium symporter activity
YPCD1.78c	COG1561	YicC-like family, N-terminal region
YPMT1.46Bc	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPMT1.46c	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPMT1.49Ac	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPMT1.50c	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPMT1.56c	COG1561	YicC-like family, N-terminal region
YPMT1.60c	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPMT1.68A	COG0156	8-amino-7-oxononanoate synthase activity
YPO0001	COG0716	FMN binding
YPO0002	COG1522	sequence-specific DNA binding
YPO0008	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPO0009	COG0477	Major facilitator Superfamily
YPO0010	COG2186	Transcriptional regulator
YPO0011	COG3328	transposase activity
YPO0012	COG1763	Mo-molybdopterin cofactor biosynthetic process
YPO0013a	COG3084	Protein conserved in bacteria
YPO0014	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YPO0015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPO0017	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPO0017	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPO0021	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPO0023	COG3852	Histidine kinase
YPO0024	COG0174	glutamine synthetase
YPO0027	COG1011	Hydrolase
YPO0032	COG0456	acetyltransferase
YPO0033	COG2982	Protein involved in outer membrane biogenesis
YPO0034	COG2233	PERMEase
YPO0035	COG0786	glutamate:sodium symporter activity
YPO0036	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPO0037	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPO0038	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPO0042	COG2860	membrane
YPO0043	COG1561	YicC-like family, N-terminal region
YPO0048	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPO0055	COG1519	Transferase
YPO0056	COG0859	PFAM glycosyl transferase family 9
YPO0057	COG0859	PFAM glycosyl transferase family 9
YPO0059	COG0156	8-amino-7-oxononanoate synthase activity
YPO0063	COG4942	peptidase
YPO0065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPO0066	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPO0070	COG1045	serine acetyltransferase
YPO0071	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YPO0072	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPO0072	COG2169	Transcriptional regulator
YPO0073	COG2205	protein histidine kinase activity
YPO0074	COG0745	RESPONSE REGULATOR receiver
YPO0075	COG3678	ATP-independent chaperone mediated protein folding
YPO0079	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YPO0081	COG0471	metal ion transport
YPO0082	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YPO0083	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YPO0084	COG0583	DNA-binding transcription factor activity
YPO0087	COG3152	Membrane
YPO0089	COG1494	fructose-1,6-bisphosphatase
YPO0090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPO0091	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YPO0104	COG1575	Belongs to the MenA family. Type 1 subfamily
YPO0107	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPO0108	COG1609	Transcriptional regulator
YPO0110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YPO0112	COG4682	membrane
YPO0116	COG0460	homoserine dehydrogenase
YPO0116	COG0527	aspartate kinase activity
YPO0118	COG2801	Transposase and inactivated derivatives
YPO0120	COG1349	DNA-binding transcription factor activity
YPO0122	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPO0126	COG1640	4-alpha-glucanotransferase
YPO0133	COG1918	ferrous iron import across plasma membrane
YPO0134	COG2183	response to ionizing radiation
YPO0135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPO0140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YPO0141	COG1011	Hydrolase
YPO0144	COG0494	nUDIX hydrolase
YPO0145	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YPO0150	COG4796	Type ii and iii secretion system protein
YPO0155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YPO0156	COG0546	phosphoglycolate phosphatase activity
YPO0157	COG0180	Tryptophanyl-tRNA synthetase
YPO0161	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YPO0162	COG0402	S-adenosylhomocysteine deaminase activity
YPO0166	COG1486	melibiose metabolic process
YPO0167	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPO0168	COG0433	COG0433 Predicted ATPase
YPO0174	COG1289	transmembrane transporter activity
YPO0176	COG1765	OsmC-like protein
YPO0178	COG3954	Phosphoribulokinase
YPO0180	COG0429	hydrolase of the alpha beta-hydrolase fold
YPO0182	COG4521	taurine ABC transporter
YPO0184	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPO0185	COG2175	clavaminate synthase activity
YPO0187	COG1216	Glycosyl transferase, family 2
YPO0192	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YPO0193	COG1047	Peptidyl-prolyl cis-trans
YPO0195	COG0545	Peptidyl-prolyl cis-trans isomerase
YPO0196	COG2964	Protein conserved in bacteria
YPO0200	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YPO0201	COG0049	tRNA binding
YPO0209	COG0051	transcription antitermination factor activity, RNA binding
YPO0212	COG0089	rRNA binding
YPO0214	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YPO0216	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YPO0217	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YPO0219	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YPO0220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YPO0227	COG1841	ribosomal large subunit assembly
YPO0229	COG0201	protein transport
YPO0230	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YPO0233	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YPO0236	COG0789	Transcriptional regulator
YPO0237	COG3036	rescue of stalled ribosome
YPO0243	COG0758	DNA mediated transformation
YPO0245	COG0551	DNA topoisomerase type I activity
YPO0247	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YPO0252	COG3162	membrane
YPO0254	COG1301	dicarboxylic acid transport
YPO0274	COG2391	methyltransferase activity
YPO0275	COG0425	Belongs to the sulfur carrier protein TusA family
YPO0276	COG0583	DNA-binding transcription factor activity
YPO0277	COG0814	amino acid
YPO0278	COG0626	cystathionine gamma-synthase activity
YPO0280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPO0281	COG4558	Periplasmic binding protein
YPO0282	COG3720	iron ion transport
YPO0283	COG4771	TonB-dependent receptor
YPO0284	COG0702	epimerase
YPO0285	COG3721	Heme iron utilization protein
YPO0290	COG1358	cellular component organization or biogenesis
YPO0303	COG3121	Chaperone
YPO0313	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YPO0315	COG0735	belongs to the Fur family
YPO0316	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPO0322	COG1448	Aminotransferase
YPO0323	COG2315	Protein conserved in bacteria
YPO0324	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YPO0325	COG0629	single-stranded DNA binding
YPO0327	COG1454	alcohol dehydrogenase
YPO0341	COG1309	transcriptional regulator
YPO0342	COG0493	'glutamate synthase
YPO0342	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPO0343	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPO0344	COG3383	formate dehydrogenase (NAD+) activity
YPO0347	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPO0357	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YPO0359	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YPO0360	COG1053	succinate dehydrogenase
YPO0363	COG3264	Mechanosensitive ion channel
YPO0363	COG1511	domain protein
YPO0366	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YPO0367	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YPO0368	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YPO0368	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YPO0369	COG0802	atpase or kinase
YPO0370	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPO0374	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YPO0375	COG0330	HflC and HflK could
YPO0376	COG0330	HflC and HflK could
YPO0377	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
YPO0380	COG0557	exoribonuclease II activity
YPO0381	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPO0383	COG1960	acyl-CoA dehydrogenase activity
YPO0384	COG3650	response to hydrogen peroxide
YPO0387	COG1401	restriction endodeoxyribonuclease activity
YPO0392a	COG2963	transposase activity
YPO0399	COG4269	membrane
YPO0401	COG2207	Transcriptional regulator
YPO0402	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPO0403	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPO0404	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPO0405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO0405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO0405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPO0415	COG1070	Carbohydrate kinase
YPO0416	COG0859	PFAM glycosyl transferase family 9
YPO0420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPO0421	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPO0428	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YPO0429	COG0456	acetyltransferase
YPO0431	COG2823	Periplasmic or secreted lipoprotein
YPO0433	COG4667	esterase of the alpha-beta hydrolase superfamily
YPO0434	COG0084	hydrolase, TatD family'
YPO0435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPO0441	COG3726	membrane protein affecting hemolysin expression
YPO0442	COG0560	Phosphoserine phosphatase
YPO0448	COG2885	chlorophyll binding
YPO0449	COG2199	diguanylate cyclase activity
YPO0452	COG0741	lytic transglycosylase activity
YPO0453	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YPO0456	COG2207	Transcriptional regulator
YPO0456	COG3708	Transcriptional regulator
YPO0457	COG3045	CreA protein
YPO0458	COG0745	RESPONSE REGULATOR receiver
YPO0464	COG0521	Mo-molybdopterin cofactor biosynthetic process
YPO0467	COG1584	GPR1 FUN34 yaaH family protein
YPO0471	COG0583	DNA-binding transcription factor activity
YPO0474	COG0196	riboflavin kinase activity
YPO0476a	COG1047	Peptidyl-prolyl cis-trans
YPO0482	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YPO0483	COG1280	lysine exporter protein (LysE YggA)
YPO0484	COG2966	Psort location CytoplasmicMembrane, score
YPO0486	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YPO0496	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YPO0497	COG0564	pseudouridine synthase activity
YPO0514	COG3047	cAMP biosynthetic process
YPO0514	COG2885	chlorophyll binding
YPO0518	COG0417	DNA replication proofreading
YPO0519	COG0586	Pfam SNARE associated Golgi protein
YPO0520	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
YPO0521	COG1178	ABC-type Fe3 transport system permease component
YPO0522	COG4143	(ABC) transporter
YPO0532	COG0473	3-isopropylmalate dehydrogenase activity
YPO0537	COG1022	Amp-dependent synthetase and ligase
YPO0539	COG0028	Belongs to the TPP enzyme family
YPO0543	COG1609	Transcriptional regulator
YPO0548	COG3116	cell division
YPO0549	COG0768	penicillin binding
YPO0550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YPO0551	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YPO0554	COG0772	Belongs to the SEDS family
YPO0558	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YPO0559	COG0849	cell division
YPO0560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YPO0565	COG0494	nUDIX hydrolase
YPO0568	COG2259	Doxx family
YPO0569a	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YPO0570	COG4575	ribosome binding
YPO0574	COG0586	Pfam SNARE associated Golgi protein
YPO0577	COG2271	Major facilitator Superfamily
YPO0581	COG2721	sulfolactate sulfo-lyase activity
YPO0585	COG0673	inositol 2-dehydrogenase activity
YPO0586	COG1451	nucleotide metabolic process
YPO0589	COG0446	pyridine nucleotide-disulphide oxidoreductase
YPO0589	COG1902	pentaerythritol trinitrate reductase activity
YPO0590	COG3247	response to pH
YPO0594	COG4245	von Willebrand factor, type A
YPO0597	COG4245	von Willebrand factor, type A
YPO0598	COG2831	hemolysin activation secretion protein
YPO0599	COG3210	domain, Protein
YPO0602a	COG3210	domain, Protein
YPO0602b	COG3210	domain, Protein
YPO0609	COG3842	ATPase activity
YPO0610	COG3459	Glycosyltransferase 36 associated
YPO0611	COG1609	Transcriptional regulator
YPO0612	COG2182	Extracellular solute-binding protein
YPO0614	COG0395	ABC-type sugar transport system, permease component
YPO0618	COG1289	transmembrane transporter activity
YPO0623	COG0436	Aminotransferase
YPO0627	COG0251	oxidation-reduction process
YPO0644	COG0358	DNA primase activity
YPO0645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YPO0648	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YPO0651	COG4991	sh3 domain protein
YPO0652	COG3025	triphosphatase activity
YPO0655	COG0531	amino acid
YPO0659	COG3384	dioxygenase
YPO0660	COG0754	glutathionylspermidine amidase activity
YPO0663	COG1538	Outer membrane efflux protein
YPO0664	COG0494	nUDIX hydrolase
YPO0665	COG3151	Protein conserved in bacteria
YPO0666	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YPO0667	COG3150	esterase
YPO0669	COG0583	DNA-binding transcription factor activity
YPO0670	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPO0671	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YPO0673	COG2132	Multicopper oxidase
YPO0676	COG0656	L-ascorbic acid biosynthetic process
YPO0678	COG1979	alcohol dehydrogenase
YPO0679	COG2207	Transcriptional regulator
YPO0680	COG0586	Pfam SNARE associated Golgi protein
YPO0681	COG0626	cystathionine gamma-synthase activity
YPO0682	COG0811	peptide transport
YPO0683	COG0848	biopolymer transport protein
YPO0701	COG4592	Periplasmic binding protein
YPO0706	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPO0707	COG1684	flagellar biosynthetic protein fliR
YPO0708	COG1987	bacterial-type flagellum assembly
YPO0713	COG1677	Flagellar hook-basal body complex protein FliE
YPO0721	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
YPO0722	COG1815	bacterial-type flagellum-dependent cell motility
YPO0723	COG1558	bacterial-type flagellum-dependent cell motility
YPO0724	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPO0725	COG1749	Flagellar hook protein flgE
YPO0728	COG4786	Flagellar basal body rod
YPO0730	COG1706	bacterial-type flagellum-dependent cell motility
YPO0732	COG1256	bacterial-type flagellum assembly
YPO0736	COG3710	Transcriptional regulator
YPO0740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YPO0745	COG1191	sigma factor activity
YPO0746	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YPO0756	COG2801	Transposase and inactivated derivatives
YPO0759	COG0471	metal ion transport
YPO0762	COG3209	COG3209 Rhs family protein
YPO0764	COG3501	Rhs element vgr protein
YPO0767	COG2610	gluconate transmembrane transporter activity
YPO0770	COG1132	(ABC) transporter
YPO0771	COG2375	cellular response to nickel ion
YPO0771	COG1132	(ABC) transporter
YPO0776	COG2226	methyltransferase
YPO0776	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPO0776	COG3433	isochorismatase activity
YPO0778	COG3433	isochorismatase activity
YPO0778	COG2226	methyltransferase
YPO0778	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPO0790	COG0667	Aldo Keto reductase
YPO0795	COG1609	Transcriptional regulator
YPO0797	COG0583	DNA-binding transcription factor activity
YPO0798	COG2814	Major facilitator Superfamily
YPO0799	COG0583	DNA-binding transcription factor activity
YPO0802	COG0840	transmembrane signaling receptor activity
YPO0811	COG2165	general secretion pathway protein
YPO0815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPO0819	COG0288	reversible hydration of carbon dioxide
YPO0829	COG3119	arylsulfatase activity
YPO0831	COG1349	DNA-binding transcription factor activity
YPO0833	COG2222	sugar isomerase
YPO0834	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPO0835	COG3715	PTS system
YPO0836	COG3716	PTS system mannose fructose sorbose family IID component
YPO0837	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO0839	COG1028	Short-chain dehydrogenase reductase Sdr
YPO0841	COG0641	radical SAM
YPO0842	COG3119	arylsulfatase activity
YPO0847	COG2271	Major facilitator Superfamily
YPO0850a	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPO0850a	COG1263	PTS System
YPO0852	COG1874	Beta-galactosidase
YPO0853	COG3867	Arabinogalactan endo-beta-1,4-galactanase
YPO0854	COG3833	ABC-type maltose transport systems, permease component
YPO0855	COG1175	transmembrane transport
YPO0856	COG2182	Extracellular solute-binding protein
YPO0858	COG1129	ABC transporter
YPO0859	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO0860	COG1879	ABC-type sugar transport system periplasmic component
YPO0863	COG0791	NLP P60 protein
YPO0864	COG1695	Transcriptional regulator
YPO0881	COG2944	sequence-specific DNA binding
YPO0887	COG0582	viral genome integration into host DNA
YPO0890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YPO0891	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPO0892	COG4974	Belongs to the 'phage' integrase family
YPO0893	COG0716	FMN binding
YPO0894	COG4452	Inner membrane protein CreD
YPO0895	COG2205	protein histidine kinase activity
YPO0896	COG0745	RESPONSE REGULATOR receiver
YPO0900	COG1272	protein, Hemolysin III
YPO0908	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPO0909	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPO0910	COG0006	proline dipeptidase activity
YPO0913	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YPO0914	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YPO0920	COG0191	fructose-bisphosphate aldolase activity
YPO0926	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YPO0927	COG0501	Belongs to the peptidase M48B family
YPO0929	COG1166	arginine decarboxylase activity
YPO0932	COG3091	SprT-like family
YPO0933	COG2356	endonuclease I
YPO0934	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YPO0935	COG0189	ligase activity
YPO0938	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPO0940	COG2805	Type II/IV secretion system protein
YPO0941	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YPO0942	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YPO0943	COG0762	integral membrane protein
YPO0945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
YPO0946	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPO0947	COG1073	alpha beta
YPO0947	COG3064	Membrane
YPO0947	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YPO0950	COG3171	Protein conserved in bacteria
YPO0952	COG1194	a g-specific adenine glycosylase
YPO0956	COG4774	siderophore transport
YPO0957	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO0958	COG1129	ABC transporter
YPO0959	COG1879	ABC-type sugar transport system periplasmic component
YPO0960	COG1982	Orn Lys Arg decarboxylase major
YPO0984	COG3916	Acyl-homoserine-lactone synthase
YPO0985	COG2771	luxR family
YPO0995	COG2211	Major facilitator Superfamily
YPO0997	COG2801	Transposase and inactivated derivatives
YPO0998	COG5001	Diguanylate cyclase
YPO1000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPO1008	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YPO1009	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPO1011	COG4771	TonB-dependent receptor
YPO1018	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YPO1020	COG1074	ATP-dependent DNA helicase activity
YPO1021	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YPO1023	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPO1025	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YPO1026	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YPO1027	COG2166	iron-sulfur cluster assembly
YPO1028	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YPO1029	COG0583	DNA-binding transcription factor activity
YPO1030	COG2363	Small membrane protein
YPO1033	COG1611	Belongs to the LOG family
YPO1037	COG3098	single-species biofilm formation
YPO1038	COG0564	pseudouridine synthase activity
YPO1050	COG0575	Belongs to the CDS family
YPO1051	COG0750	zinc metalloprotease
YPO1054	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YPO1059	COG0587	DNA-directed DNA polymerase activity
YPO1061	COG0346	lactoylglutathione lyase activity
YPO1062	COG0037	tRNA processing
YPO1064	COG4568	rho-dependent transcription termination
YPO1065	COG4681	YaeQ
YPO1067	COG3015	lipoprotein NlpE involved in copper resistance
YPO1069	COG1720	tRNA m6t6A37 methyltransferase activity
YPO1071	COG1464	Belongs to the NlpA lipoprotein family
YPO1072	COG2011	ABC-type metal ion transport system permease component
YPO1074	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPO1075	COG0656	L-ascorbic acid biosynthetic process
YPO1078	COG1388	LysM domain
YPO1078	COG0741	lytic transglycosylase activity
YPO1079	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPO1080	COG2226	methyltransferase
YPO1083	COG1953	Uracil, thiamine, allantoin
YPO1098	COG0582	viral genome integration into host DNA
YPO1102	COG2867	negative regulation of translational initiation
YPO1104	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPO1105	COG0497	DNA recombination
YPO1106	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YPO1109	COG2009	succinate dehydrogenase
YPO1110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YPO1111	COG1053	succinate dehydrogenase
YPO1113	COG0567	Dehydrogenase, E1 component
YPO1114	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPO1116	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YPO1117	COG1271	oxidase subunit
YPO1118	COG1294	oxidase, subunit
YPO1119	COG3790	cyd operon protein YbgE
YPO1120	COG0824	Thioesterase
YPO1121	COG0811	peptide transport
YPO1122	COG0848	biopolymer transport protein
YPO1123	COG3064	Membrane
YPO1123	COG3064	Membrane
YPO1125	COG2885	chlorophyll binding
YPO1126	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YPO1129	COG1230	cation diffusion facilitator family transporter
YPO1129a	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPO1138	COG1085	galactose-1-phosphate uridylyltransferase
YPO1139	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YPO1142	COG1119	ATPase activity
YPO1143	COG2005	Transcriptional regulator
YPO1143	COG3585	molybdate ion transport
YPO1145	COG0725	ABC transporter, periplasmic molybdate-binding protein
YPO1146	COG4149	molybdate abc transporter
YPO1148	COG0561	phosphatase activity
YPO1153	COG2226	methyltransferase
YPO1155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
YPO1157	COG4628	conserved protein (DUF2132)
YPO1158	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YPO1159	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YPO1161	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YPO1162	COG0314	molybdopterin synthase activity
YPO1163	COG0670	Belongs to the BI1 family
YPO1168	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPO1169	COG0583	DNA-binding transcription factor activity
YPO1171	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YPO1172	COG2211	Major facilitator Superfamily
YPO1175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPO1176	COG1686	Belongs to the peptidase S11 family
YPO1177	COG0277	FAD linked oxidase domain protein
YPO1181	COG2261	transglycosylase associated protein
YPO1183	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YPO1186	COG4807	Protein conserved in bacteria
YPO1190	COG1122	ATPase activity
YPO1194	COG2897	thiosulfate sulfurtransferase activity
YPO1197	COG1174	glycine betaine transport
YPO1198	COG1125	glycine betaine transport
YPO1199	COG1174	glycine betaine transport
YPO1200	COG0531	amino acid
YPO1201	COG1982	Orn Lys Arg decarboxylase major
YPO1203	COG0697	spore germination
YPO1209	COG0814	amino acid
YPO1212	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPO1217	COG2205	protein histidine kinase activity
YPO1217	COG0784	Response regulator, receiver
YPO1221	COG2223	nitrite transmembrane transporter activity
YPO1224	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YPO1235	COG3395	kinase activity
YPO1236	COG0235	Class ii aldolase
YPO1237	COG1349	DNA-binding transcription factor activity
YPO1238	COG3622	Belongs to the hyi family
YPO1242	COG4386	tail sheath protein
YPO1250	COG3299	homolog of phage Mu protein gp47
YPO1253	COG1737	Transcriptional regulator
YPO1254	COG2723	6-phospho-beta-galactosidase activity
YPO1258	COG3157	Type VI secretion system effector, Hcp
YPO1260	COG3083	sulfuric ester hydrolase activity
YPO1261	COG3082	Protein of unknown function (DUF1414)
YPO1265	COG1061	Type III restriction enzyme res subunit
YPO1266	COG1187	pseudouridine synthase activity
YPO1267	COG2814	Major facilitator Superfamily
YPO1270	COG4172	Belongs to the ABC transporter superfamily
YPO1271	COG4239	(ABC) transporter, permease
YPO1272	COG4174	ABC transporter (Permease)
YPO1273	COG4166	transmembrane transport
YPO1275	COG0791	NLP P60 protein
YPO1276	COG0671	phosphoesterase, PA-phosphatase related
YPO1277	COG0523	cobalamin synthesis protein
YPO1279	COG2186	Transcriptional regulator
YPO1280	COG0246	Mannitol dehydrogenase
YPO1287	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1294	COG1129	ABC transporter
YPO1296	COG0494	nUDIX hydrolase
YPO1299	COG1105	Belongs to the carbohydrate kinase PfkB family
YPO1300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPO1300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPO1300	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YPO1301	COG3710	Transcriptional regulator
YPO1304	COG3121	Chaperone
YPO1305	COG3188	usher protein
YPO1307	COG2855	membrane
YPO1308	COG0583	DNA-binding transcription factor activity
YPO1309	COG0833	amino acid
YPO1311	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPO1313	COG4771	TonB-dependent receptor
YPO1314	COG0625	glutathione transferase activity
YPO1319	COG2011	ABC-type metal ion transport system permease component
YPO1320	COG1686	Belongs to the peptidase S11 family
YPO1321	COG0814	amino acid
YPO1322	COG1349	DNA-binding transcription factor activity
YPO1324	COG0671	phosphoesterase, PA-phosphatase related
YPO1331	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YPO1332	COG3842	ATPase activity
YPO1333	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPO1334	COG1177	transmembrane transport
YPO1345	COG1120	ATPase activity
YPO1349	COG4160	amino acid transport
YPO1350	COG4215	(ABC) transporter
YPO1351	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPO1352	COG1126	abc transporter atp-binding protein
YPO1353	COG1605	Chorismate mutase
YPO1355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPO1356	COG0702	epimerase
YPO1357	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YPO1358	COG0028	Belongs to the TPP enzyme family
YPO1359	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPO1361	COG2431	L-lysine efflux transmembrane transporter activity
YPO1362	COG3593	DNA synthesis involved in DNA repair
YPO1363	COG2990	Protein conserved in bacteria
YPO1364	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPO1366	COG1278	Cold shock
YPO1368	COG0542	response to heat
YPO1370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YPO1372	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YPO1374	COG0492	ferredoxin-NADP+ reductase activity
YPO1376	COG1674	ftsk spoiiie
YPO1376	COG3107	peptidoglycan biosynthetic process
YPO1378	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YPO1381	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YPO1383	COG1882	Formate acetyltransferase
YPO1384	COG2116	formate transmembrane transporter activity
YPO1385	COG1944	ATP diphosphatase activity
YPO1386	COG0252	asparaginase activity
YPO1387	COG5295	Hep Hag repeat protein
YPO1387	COG5295	Hep Hag repeat protein
YPO1392	COG0539	negative regulation of cytoplasmic translation
YPO1394	COG0658	competence protein
YPO1394	COG2333	competence protein COMEC
YPO1397	COG5383	Protein conserved in bacteria
YPO1398	COG1278	Cold shock
YPO1401	COG3173	Aminoglycoside phosphotransferase
YPO1402	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YPO1407	COG2989	Protein conserved in bacteria
YPO1408	COG3108	Peptidase M15
YPO1409	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPO1410	COG1448	Aminotransferase
YPO1414	COG0308	aminopeptidase N
YPO1417	COG0633	Ferredoxin
YPO1417	COG3217	Mosc domain protein beta barrel domain protein
YPO1419	COG0488	(ABC) transporter
YPO1420	COG2995	paraquat-inducible protein a
YPO1421	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPO1421	COG3008	intermembrane lipid transfer
YPO1422	COG3009	Protein conserved in bacteria
YPO1423a	COG3130	regulation of translation
YPO1425a	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPO1427b	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPO1431	COG1067	ATP-dependent peptidase activity
YPO1437	COG3070	regulator of competence-specific genes
YPO1438	COG1289	transmembrane transporter activity
YPO1439	COG3304	Inner membrane component domain
YPO1440	COG0210	DNA helicase
YPO1443	COG1832	CoA-binding protein
YPO1447	COG2920	part of a sulfur-relay system
YPO1452	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1454	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YPO1455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPO1456	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1457	COG3425	synthase
YPO1459	COG1024	Enoyl-CoA hydratase
YPO1460	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1462	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YPO1463	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YPO1491	COG0488	(ABC) transporter
YPO1493	COG3328	transposase activity
YPO1495	COG0303	'Molybdopterin
YPO1497	COG1136	(ABC) transporter
YPO1503	COG0583	DNA-binding transcription factor activity
YPO1504	COG0477	Major facilitator Superfamily
YPO1506	COG2311	Membrane
YPO1509	COG4211	Belongs to the binding-protein-dependent transport system permease family
YPO1510	COG2949	membrane
YPO1513	COG1346	cytolysis
YPO1515	COG2814	Major facilitator Superfamily
YPO1523	COG0489	protein tyrosine kinase activity
YPO1526	COG2982	Protein involved in outer membrane biogenesis
YPO1527	COG1253	flavin adenine dinucleotide binding
YPO1528	COG4114	ferric iron reductase
YPO1529	COG0076	glutamate decarboxylase activity
YPO1530	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YPO1533	COG1120	ATPase activity
YPO1534	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPO1535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPO1536	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPO1539	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPO1540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPO1542	COG0140	phosphoribosyl-ATP diphosphatase activity
YPO1542	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YPO1546	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPO1546	COG0131	Imidazoleglycerol-phosphate dehydratase
YPO1548	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YPO1551	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPO1553	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO1556	COG0371	Dehydrogenase
YPO1557	COG0531	amino acid
YPO1558	COG2925	Exonuclease
YPO1561	COG3328	transposase activity
YPO1562	COG1470	cell adhesion involved in biofilm formation
YPO1562	COG1388	LysM domain
YPO1563	COG2271	Major facilitator Superfamily
YPO1564	COG3011	Protein conserved in bacteria
YPO1565	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1567	COG4948	Mandelate Racemase Muconate Lactonizing
YPO1571	COG0534	Mate efflux family protein
YPO1575	COG3122	Protein conserved in bacteria
YPO1579	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YPO1582	COG2223	nitrite transmembrane transporter activity
YPO1583	COG3328	transposase activity
YPO1588	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YPO1589	COG3328	transposase activity
YPO1590	COG1530	ribonuclease E activity
YPO1591	COG0564	pseudouridine synthase activity
YPO1593	COG0424	maF-like protein
YPO1594	COG1399	metal-binding, possibly nucleic acid-binding protein
YPO1595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YPO1601	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPO1603	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPO1604	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YPO1606	COG0470	DNA polymerase III
YPO1607	COG0084	hydrolase, TatD family'
YPO1608	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPO1608	COG1263	PTS System
YPO1610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YPO1611	COG0537	adenosine 5'-monophosphoramidase activity
YPO1612	COG5633	Lipoprotein
YPO1615	COG1472	Belongs to the glycosyl hydrolase 3 family
YPO1617	COG1252	NADH dehydrogenase
YPO1621	COG3328	transposase activity
YPO1624	COG3134	Outer membrane lipoprotein
YPO1625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YPO1626	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPO1628	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPO1629	COG1940	carbohydrate kinase activity
YPO1632	COG2850	peptidyl-arginine hydroxylation
YPO1634	COG0745	RESPONSE REGULATOR receiver
YPO1636	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YPO1640	COG1187	pseudouridine synthase activity
YPO1641	COG0538	isocitrate dehydrogenase activity
YPO1644	COG0840	transmembrane signaling receptor activity
YPO1645	COG0702	epimerase
YPO1646	COG1733	regulation of RNA biosynthetic process
YPO1651	COG1522	sequence-specific DNA binding
YPO1653	COG0604	alcohol dehydrogenase
YPO1653	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1653	COG3321	synthase
YPO1660	COG1285	pathogenesis
YPO1665	COG1360	Flagellar Motor Protein
YPO1666	COG0643	Histidine kinase
YPO1666	COG2198	Histidine kinase
YPO1667	COG0835	chemotaxis
YPO1668	COG2271	Major facilitator Superfamily
YPO1669	COG0251	oxidation-reduction process
YPO1671	COG2964	Protein conserved in bacteria
YPO1675	COG0840	transmembrane signaling receptor activity
YPO1678	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YPO1680	COG0745	RESPONSE REGULATOR receiver
YPO1681	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YPO1683	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPO1687	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPO1697	COG3121	Chaperone
YPO1701	COG3008	intermembrane lipid transfer
YPO1702	COG2995	paraquat-inducible protein a
YPO1703	COG1956	GAF domain-containing protein
YPO1705	COG0793	Belongs to the peptidase S41A family
YPO1707	COG3539	Fimbrial protein
YPO1708	COG3121	Chaperone
YPO1711	COG3121	Chaperone
YPO1712	COG2814	Major facilitator Superfamily
YPO1713	COG0823	Involved in the tonB-independent uptake of proteins
YPO1715	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPO1716	COG1823	symporter activity
YPO1717	COG1988	membrane-bound metal-dependent
YPO1718	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPO1719	COG1653	transport
YPO1720	COG3842	ATPase activity
YPO1721	COG0395	ABC-type sugar transport system, permease component
YPO1722	COG1175	transmembrane transport
YPO1724	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1726	COG1917	Cupin 2, conserved barrel domain protein
YPO1727	COG3328	transposase activity
YPO1735	COG1132	(ABC) transporter
YPO1737	COG2207	Transcriptional regulator
YPO1743	COG1113	amino acid transport
YPO1747	COG1496	oxidoreductase activity
YPO1748	COG2226	methyltransferase
YPO1751a	COG3447	MASE1 domain protein
YPO1751a	COG5002	protein histidine kinase activity
YPO1751a	COG5001	Diguanylate cyclase
YPO1756	COG3716	PTS system mannose fructose sorbose family IID component
YPO1757	COG3715	PTS system
YPO1758	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO1758	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPO1760	COG1846	Transcriptional regulator
YPO1763	COG1012	belongs to the aldehyde dehydrogenase family
YPO1764	COG3384	dioxygenase
YPO1766	COG3971	2-oxopent-4-enoate hydratase activity
YPO1769	COG2368	4-hydroxyphenylacetate
YPO1770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YPO1771	COG1760	l-serine dehydratase
YPO1776	COG0513	Belongs to the DEAD box helicase family
YPO1777	COG3141	response to X-ray
YPO1780	COG1770	oligopeptidase
YPO1783	COG1528	Iron-storage protein
YPO1784	COG2372	response to copper ion
YPO1790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPO1791	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPO1796	COG3418	PFAM FlgN family protein
YPO1797	COG2747	anti-sigma28 factor FlgM
YPO1799	COG1815	bacterial-type flagellum-dependent cell motility
YPO1800	COG1558	bacterial-type flagellum-dependent cell motility
YPO1808	COG1256	bacterial-type flagellum assembly
YPO1810	COG2390	Transcriptional regulator
YPO1811	COG1028	Short-chain dehydrogenase reductase Sdr
YPO1811	COG3347	Dehydrogenase
YPO1812	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO1814	COG1129	ABC transporter
YPO1815	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO1816	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPO1820a	COG1987	bacterial-type flagellum assembly
YPO1824	COG1580	Controls the rotational direction of flagella during chemotaxis
YPO1827	COG1157	protein secretion by the type III secretion system
YPO1831	COG1677	Flagellar hook-basal body complex protein FliE
YPO1834	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YPO1843	COG1191	sigma factor activity
YPO1846	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPO1847	COG0765	amino acid transport
YPO1848	COG1126	abc transporter atp-binding protein
YPO1851	COG0506	proline dehydrogenase activity
YPO1851	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPO1851	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPO1854	COG0672	)-iron permease
YPO1855	COG2822	iron ion transport
YPO1859	COG1113	amino acid transport
YPO1863	COG3136	membrane protein required for alginate biosynthesis
YPO1865	COG2197	response regulator
YPO1890	COG2188	Transcriptional regulator
YPO1892	COG0673	inositol 2-dehydrogenase activity
YPO1894	COG1175	transmembrane transport
YPO1895	COG0395	ABC-type sugar transport system, permease component
YPO1906	COG4771	TonB-dependent receptor
YPO1907	COG1021	2,3-dihydroxybenzoate-AMP ligase
YPO1911	COG3433	isochorismatase activity
YPO1911	COG2226	methyltransferase
YPO1911	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPO1914	COG1132	(ABC) transporter
YPO1915	COG2814	Major facilitator Superfamily
YPO1916	COG1169	isochorismate synthase
YPO1917	COG0582	viral genome integration into host DNA
YPO1918	COG3121	Chaperone
YPO1920	COG3188	usher protein
YPO1926	COG0427	acetyl-CoA hydrolase
YPO1927	COG2030	dehydratase
YPO1932	COG2814	Major facilitator Superfamily
YPO1935	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPO1936	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPO1938	COG1349	DNA-binding transcription factor activity
YPO1939	COG2066	Belongs to the glutaminase family
YPO1941	COG0672	)-iron permease
YPO1944	COG0577	efflux transmembrane transporter activity
YPO1944	COG1136	(ABC) transporter
YPO1946	COG0577	efflux transmembrane transporter activity
YPO1946	COG1136	(ABC) transporter
YPO1950	COG0006	proline dipeptidase activity
YPO1951	COG0457	Tetratricopeptide repeat
YPO1952	COG1649	PFAM Uncharacterised BCR, COG1649
YPO1952	COG0726	polysaccharide deacetylase
YPO1953	COG1215	transferase activity, transferring glycosyl groups
YPO1954	COG3658	cytochrome
YPO1957	COG1702	phosphate starvation-inducible protein PhoH
YPO1958	COG0387	Pfam Sodium calcium exchanger
YPO1959	COG3850	Histidine kinase
YPO1960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPO1974	COG0402	S-adenosylhomocysteine deaminase activity
YPO1979	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPO1988	COG3328	transposase activity
YPO1992	COG0500	methyltransferase
YPO2000	COG5002	protein histidine kinase activity
YPO2010	COG0012	GTP binding
YPO2013	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YPO2018	COG2890	protein-(glutamine-N5) methyltransferase activity
YPO2030	COG3833	ABC-type maltose transport systems, permease component
YPO2031	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPO2035	COG0584	glycerophosphoryl diester phosphodiesterase
YPO2036	COG1940	carbohydrate kinase activity
YPO2038	COG3381	protein complex oligomerization
YPO2041	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPO2043	COG0728	peptidoglycan biosynthetic process
YPO2047	COG3102	Protein conserved in bacteria
YPO2051	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YPO2052	COG1801	Protein of unknown function DUF72
YPO2054	COG0494	nUDIX hydrolase
YPO2059	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPO2061	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YPO2062	COG0739	heme binding
YPO2063	COG1560	Kdo2-lipid A biosynthetic process
YPO2064	COG0469	pyruvate kinase activity
YPO2065	COG1737	Transcriptional regulator
YPO2066	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YPO2067	COG0800	Aldolase
YPO2070	COG0251	oxidation-reduction process
YPO2071	COG1199	ATP-dependent helicase activity
YPO2073	COG3065	identical protein binding
YPO2074	COG0318	PFAM AMP-dependent synthetase and ligase
YPO2075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YPO2076	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YPO2077	COG2894	cell division
YPO2081	COG2951	lytic endotransglycosylase activity
YPO2082	COG0179	Fumarylacetoacetate (FAA) hydrolase
YPO2104	COG3328	transposase activity
YPO2136	COG3328	transposase activity
YPO2138	COG1104	cysteine desulfurase activity
YPO2145	COG2719	SpoVR family
YPO2148	COG2814	Major facilitator Superfamily
YPO2150	COG0583	DNA-binding transcription factor activity
YPO2153	COG2766	serine protein kinase
YPO2155	COG3713	MltA-interacting MipA family protein
YPO2159	COG3139	Protein of unknown function (DUF1315)
YPO2160	COG1335	isochorismatase
YPO2161	COG0252	asparaginase activity
YPO2162	COG0616	signal peptide processing
YPO2163	COG0778	Nitroreductase
YPO2164	COG0709	Synthesizes selenophosphate from selenide and ATP
YPO2165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPO2167	COG0494	nUDIX hydrolase
YPO2168	COG0708	Exodeoxyribonuclease III
YPO2169	COG0583	DNA-binding transcription factor activity
YPO2170	COG3328	transposase activity
YPO2171	COG0788	formyltetrahydrofolate deformylase activity
YPO2173	COG0745	RESPONSE REGULATOR receiver
YPO2180	COG1454	alcohol dehydrogenase
YPO2180	COG1012	belongs to the aldehyde dehydrogenase family
YPO2181	COG2095	MarC family integral membrane protein
YPO2183	COG0601	transmembrane transport
YPO2184	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPO2185	COG0444	Belongs to the ABC transporter superfamily
YPO2186	COG4608	Belongs to the ABC transporter superfamily
YPO2192	COG2350	Protein conserved in bacteria
YPO2193	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YPO2194	COG3328	transposase activity
YPO2201	COG3047	cAMP biosynthetic process
YPO2205	COG0134	indole-3-glycerol-phosphate synthase activity
YPO2205	COG0135	phosphoribosylanthranilate isomerase activity
YPO2207	COG0512	Glutamine amidotransferase of anthranilate synthase
YPO2212	COG0009	L-threonylcarbamoyladenylate synthase
YPO2213	COG1187	pseudouridine synthase activity
YPO2215	COG1028	Short-chain dehydrogenase reductase Sdr
YPO2216	COG0616	signal peptide processing
YPO2219	COG0583	DNA-binding transcription factor activity
YPO2221	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YPO2223	COG0671	phosphoesterase, PA-phosphatase related
YPO2224	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YPO2225	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
YPO2228	COG0023	Translation Initiation Factor
YPO2232	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YPO2233	COG2879	small protein
YPO2234	COG1966	Carbon starvation protein
YPO2237	COG2271	Major facilitator Superfamily
YPO2238	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPO2239	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YPO2241	COG4659	FMN binding
YPO2242	COG4658	electron transport chain
YPO2243	COG3708	Transcriptional regulator
YPO2243	COG2207	Transcriptional regulator
YPO2252	COG2274	protein secretion by the type I secretion system
YPO2255	COG1879	ABC-type sugar transport system periplasmic component
YPO2256	COG1129	ABC transporter
YPO2257	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO2259	COG0673	inositol 2-dehydrogenase activity
YPO2260	COG0385	Bile acid
YPO2262	COG5339	Protein conserved in bacteria
YPO2263a	COG0114	fumarate hydratase activity
YPO2266	COG2814	Major facilitator Superfamily
YPO2268	COG1940	carbohydrate kinase activity
YPO2269	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPO2270	COG0038	chloride channel
YPO2279	COG4128	Pfam Zonular occludens toxin
YPO2283	COG1609	Transcriptional regulator
YPO2287	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPO2288	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPO2293	COG0028	Belongs to the TPP enzyme family
YPO2294	COG0440	acetolactate synthase activity
YPO2295	COG1011	Hydrolase
YPO2299	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPO2300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YPO2301	COG0589	response to stress
YPO2302	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YPO2303	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YPO2306	COG0531	amino acid
YPO2308	COG0745	RESPONSE REGULATOR receiver
YPO2309	COG2205	protein histidine kinase activity
YPO2310	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YPO2316	COG3038	cytochrome b561
YPO2319	COG3591	Belongs to the peptidase S1B family
YPO2322	COG1643	Atp-dependent helicase
YPO2324	COG2390	Transcriptional regulator
YPO2325	COG0246	Mannitol dehydrogenase
YPO2326	COG3784	Protein of unknown function (DUF1318)
YPO2328	COG2911	Protein conserved in bacteria
YPO2329	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPO2330	COG3187	Heat shock protein
YPO2331	COG3042	response to heat
YPO2332	COG1285	pathogenesis
YPO2334	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YPO2334	COG1013	pyruvate-flavodoxin oxidoreductase activity
YPO2334	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPO2334	COG0674	pyruvate-flavodoxin oxidoreductase activity
YPO2336	COG0657	acetylesterase activity
YPO2339	COG4166	transmembrane transport
YPO2340	COG2866	Carboxypeptidase
YPO2341	COG4948	Mandelate Racemase Muconate Lactonizing
YPO2342	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YPO2345	COG5642	Protein of unknown function (DUF2384)
YPO2346	COG5654	RES domain protein
YPO2348	COG3106	COG3106 Predicted ATPase
YPO2349	COG1983	PspC domain protein
YPO2351	COG1842	Phage shock protein A
YPO2352	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YPO2355	COG4166	transmembrane transport
YPO2356	COG4168	peptide transport system, permease
YPO2357	COG4171	peptide transport system, permease
YPO2359	COG4172	Belongs to the ABC transporter superfamily
YPO2360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPO2360	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPO2361	COG3104	oligopeptide transport
YPO2367	COG0625	glutathione transferase activity
YPO2371	COG3895	Periplasmic Protein
YPO2373	COG3133	Outer membrane lipoprotein
YPO2375	COG4989	oxidoreductase activity
YPO2376	COG3313	Fe-S protein
YPO2377	COG2194	sulfuric ester hydrolase activity
YPO2378	COG1309	transcriptional regulator
YPO2379	COG1902	pentaerythritol trinitrate reductase activity
YPO2381	COG0346	lactoylglutathione lyase activity
YPO2382	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPO2383	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YPO2385	COG0791	NLP P60 protein
YPO2388	COG0583	DNA-binding transcription factor activity
YPO2389	COG2814	Major facilitator Superfamily
YPO2390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YPO2391	COG0307	riboflavin synthase, alpha
YPO2398	COG1376	ErfK ybiS ycfS ynhG family protein
YPO2398	COG1388	LysM domain
YPO2401	COG0719	Fe-S assembly protein
YPO2402	COG0396	ATPase activity
YPO2403	COG0719	Fe-S assembly protein
YPO2404	COG0316	Belongs to the HesB IscA family
YPO2406	COG2050	protein possibly involved in aromatic compounds catabolism
YPO2407	COG0277	FAD linked oxidase domain protein
YPO2407	COG0247	lactate metabolic process
YPO2408	COG0628	permease
YPO2409	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPO2409	COG0574	Belongs to the PEP-utilizing enzyme family
YPO2415	COG0791	NLP P60 protein
YPO2424	COG0386	Belongs to the glutathione peroxidase family
YPO2427	COG0776	regulation of translation
YPO2428	COG0072	phenylalanine-tRNA ligase activity
YPO2428	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YPO2434	COG4249	Peptidase C14 caspase catalytic subunit p20
YPO2439	COG0803	Belongs to the bacterial solute-binding protein 9 family
YPO2440	COG1121	(ABC) transporter
YPO2441	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPO2442	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPO2444	COG3001	Fructosamine kinase
YPO2446	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPO2447	COG3328	transposase activity
YPO2450	COG0628	permease
YPO2456	COG3916	Acyl-homoserine-lactone synthase
YPO2457	COG2771	luxR family
YPO2458	COG0583	DNA-binding transcription factor activity
YPO2459	COG0477	Major facilitator Superfamily
YPO2461	COG0667	Aldo Keto reductase
YPO2467	COG1203	CRISPR-associated helicase, Cas3
YPO2468	COG1518	maintenance of DNA repeat elements
YPO2470	COG0668	transmembrane transport
YPO2474	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
YPO2475	COG0395	ABC-type sugar transport system, permease component
YPO2478	COG1609	Transcriptional regulator
YPO2480	COG3842	ATPase activity
YPO2482	COG3210	domain, Protein
YPO2486	COG3210	domain, Protein
YPO2490	COG3210	domain, Protein
YPO2491	COG2831	hemolysin activation secretion protein
YPO2492	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPO2493	COG4638	Rieske (2fe-2S)
YPO2494	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPO2496	COG0473	3-isopropylmalate dehydrogenase activity
YPO2497	COG0583	DNA-binding transcription factor activity
YPO2498	COG1609	Transcriptional regulator
YPO2499	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO2500	COG1129	ABC transporter
YPO2501	COG1879	ABC-type sugar transport system periplasmic component
YPO2502	COG1063	alcohol dehydrogenase
YPO2506	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPO2512	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPO2513	COG0765	amino acid transport
YPO2514	COG1126	abc transporter atp-binding protein
YPO2522	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YPO2525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
YPO2528	COG1169	isochorismate synthase
YPO2531	COG4575	ribosome binding
YPO2533	COG0129	dihydroxy-acid dehydratase activity
YPO2536	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPO2537	COG1609	Transcriptional regulator
YPO2538	COG1649	PFAM Uncharacterised BCR, COG1649
YPO2539	COG1028	Short-chain dehydrogenase reductase Sdr
YPO2540	COG3265	gluconokinase activity
YPO2541	COG2731	YhcH YjgK YiaL family protein
YPO2544	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPO2545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YPO2547	COG0839	Belongs to the complex I subunit 6 family
YPO2550	COG1034	ATP synthesis coupled electron transport
YPO2554	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPO2556	COG0583	DNA-binding transcription factor activity
YPO2558	COG0436	Aminotransferase
YPO2561	COG0490	domain, Protein
YPO2561	COG0471	metal ion transport
YPO2562	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPO2567	COG0280	phosphate acetyltransferase
YPO2567	COG0857	belongs to the CobB CobQ family
YPO2568	COG1609	Transcriptional regulator
YPO2571	COG3328	transposase activity
YPO2572	COG4953	penicillin-binding protein 1C
YPO2573	COG2373	Large extracellular alpha-helical protein
YPO2578	COG3962	Belongs to the TPP enzyme family
YPO2582	COG1129	ABC transporter
YPO2583	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO2584	COG0673	inositol 2-dehydrogenase activity
YPO2585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPO2587	COG3718	enzyme involved in inositol metabolism
YPO2588	COG5265	(ABC) transporter
YPO2593	COG2197	response regulator
YPO2596	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPO2597	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YPO2601	COG1686	Belongs to the peptidase S11 family
YPO2602	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPO2603	COG0772	Belongs to the SEDS family
YPO2604	COG0768	penicillin binding
YPO2606	COG0799	negative regulation of ribosome biogenesis
YPO2608	COG1466	dna polymerase III delta subunit
YPO2611	COG2888	peptidyl-tyrosine sulfation
YPO2612	COG1126	abc transporter atp-binding protein
YPO2613	COG0765	amino acid transport
YPO2614	COG0765	amino acid transport
YPO2616	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YPO2617	COG4535	Mg2 and Co2 transporter CorC
YPO2619	COG1702	phosphate starvation-inducible protein PhoH
YPO2620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YPO2621	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPO2623	COG0367	asparagine synthase
YPO2624	COG0647	UMP catabolic process
YPO2625	COG1940	carbohydrate kinase activity
YPO2625	COG1846	Transcriptional regulator
YPO2626	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YPO2628	COG1263	PTS System
YPO2628	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPO2628	COG2190	(PTS) system
YPO2634	COG0735	belongs to the Fur family
YPO2638	COG0596	Alpha beta hydrolase
YPO2640	COG2963	transposase activity
YPO2645	COG2113	Glycine betaine
YPO2646	COG4176	ABC-type proline glycine betaine transport system permease component
YPO2647	COG4175	Glycine betaine
YPO2648	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YPO2656	COG3328	transposase activity
YPO2659	COG1278	Cold shock
YPO2660	COG0747	negative chemotaxis
YPO2662	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPO2663	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YPO2664	COG1124	(ABC) transporter
YPO2665	COG0831	urea catabolic process
YPO2670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YPO2672	COG4413	Urea transporter
YPO2673	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YPO2675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPO2677	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPO2678	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPO2679	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPO2680	COG1447	Phosphotransferase system cellobiose-specific component IIA
YPO2681	COG1917	Cupin 2, conserved barrel domain protein
YPO2681	COG2169	Transcriptional regulator
YPO2685	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YPO2686	COG0033	Phosphoglucomutase
YPO2688	COG0745	RESPONSE REGULATOR receiver
YPO2689	COG2205	protein histidine kinase activity
YPO2694	COG3272	Protein of unknown function (DUF1722)
YPO2696	COG5212	phosphodiesterase
YPO2697	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YPO2699	COG1984	allophanate hydrolase subunit 2
YPO2708	COG0513	Belongs to the DEAD box helicase family
YPO2710	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YPO2713	COG3026	antisigma factor binding
YPO2714	COG3086	response to oxidative stress
YPO2730	COG2824	Alkylphosphonate utilization operon protein PhnA
YPO2732	COG1704	LemA family
YPO2735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPO2736	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPO2737	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPO2739	COG1138	Cytochrome C-type biogenesis protein
YPO2740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YPO2741	COG4235	cytochrome complex assembly
YPO2741	COG3088	subunit of a heme lyase
YPO2745	COG3691	Protein conserved in bacteria
YPO2748	COG2062	phosphohistidine phosphatase, SixA
YPO2750	COG2890	protein-(glutamine-N5) methyltransferase activity
YPO2752	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
YPO2753	COG0730	response to heat
YPO2754	COG3101	peptidyl-lysine hydroxylation
YPO2757	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPO2758	COG1794	racemase activity, acting on amino acids and derivatives
YPO2761	COG0697	spore germination
YPO2765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPO2767	COG0586	Pfam SNARE associated Golgi protein
YPO2769	COG0285	dihydrofolate synthase activity
YPO2770	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YPO2771	COG1286	toxin biosynthetic process
YPO2772	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YPO2774	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPO2775	COG4215	(ABC) transporter
YPO2776	COG4160	amino acid transport
YPO2777	COG4598	ABC transporter
YPO2778	COG1090	epimerase
YPO2780	COG0622	Phosphoesterase
YPO2781	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YPO2782	COG3037	sugar-specific permease SgaT UlaA
YPO2783	COG3328	transposase activity
YPO2784	COG4953	penicillin-binding protein 1C
YPO2785	COG3423	Transcriptional regulator
YPO2799	COG3328	transposase activity
YPO2803	COG1472	Belongs to the glycosyl hydrolase 3 family
YPO2805	COG0656	L-ascorbic acid biosynthetic process
YPO2806	COG0667	Aldo Keto reductase
YPO2813	COG2453	phosphatase
YPO2813	COG0671	phosphoesterase, PA-phosphatase related
YPO2814	COG2267	carboxylic ester hydrolase activity
YPO2816	COG4589	Belongs to the CDS family
YPO2817	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YPO2825	COG2501	S4 domain
YPO2829	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YPO2830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPO2834	COG0581	inorganic phosphate transmembrane transporter activity
YPO2836	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YPO2839	COG2239	Acts as a magnesium transporter
YPO2840	COG0443	Heat shock 70 kDa protein
YPO2841	COG1177	transmembrane transport
YPO2842	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPO2844	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YPO2846	COG3842	ATPase activity
YPO2853	COG0745	RESPONSE REGULATOR receiver
YPO2854	COG3422	double-strand break repair
YPO2855	COG0826	peptidase U32
YPO2859	COG0351	phosphomethylpyrimidine kinase
YPO2862	COG3328	transposase activity
YPO2871	COG0517	IMP dehydrogenase activity
YPO2871	COG0516	GMP reductase activity
YPO2873	COG1645	bacterial-type flagellum-dependent swarming motility
YPO2876	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPO2877	COG2976	Protein conserved in bacteria
YPO2886	COG3468	outer membrane autotransporter barrel domain protein
YPO2890	COG2975	iron-sulfur cluster assembly
YPO2891	COG0633	Ferredoxin
YPO2892	COG0443	Heat shock 70 kDa protein
YPO2895	COG0822	iron-sulfur transferase activity
YPO2896	COG1104	cysteine desulfurase activity
YPO2901	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YPO2902	COG3683	transport system, periplasmic component
YPO2903	COG3711	transcriptional antiterminator
YPO2904	COG2814	Major facilitator Superfamily
YPO2908	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPO2908	COG1017	nitric oxide dioxygenase activity
YPO2911	COG0347	Belongs to the P(II) protein family
YPO2912	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YPO2912	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPO2914	COG2204	response regulator
YPO2915	COG3170	Tfp pilus assembly protein FimV
YPO2916	COG2205	protein histidine kinase activity
YPO2924	COG0560	Phosphoserine phosphatase
YPO2926	COG1737	Transcriptional regulator
YPO2927	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPO2930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YPO2942	COG3328	transposase activity
YPO2944	COG3121	Chaperone
YPO2957	COG2951	lytic endotransglycosylase activity
YPO2965	COG0243	molybdopterin cofactor binding
YPO2966	COG0437	4 iron, 4 sulfur cluster binding
YPO2967	COG3302	dmso reductase anchor subunit
YPO2968	COG3381	protein complex oligomerization
YPO2974	COG3038	cytochrome b561
YPO2975	COG0436	Aminotransferase
YPO2980	COG0667	Aldo Keto reductase
YPO2983	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPO2988	COG3530	Putative quorum-sensing-regulated virulence factor
YPO2991	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
YPO2993	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO2997	COG2205	protein histidine kinase activity
YPO2998	COG0745	RESPONSE REGULATOR receiver
YPO2999	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPO3002	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YPO3006	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YPO3008	COG3850	Histidine kinase
YPO3008	COG5002	protein histidine kinase activity
YPO3009	COG0745	RESPONSE REGULATOR receiver
YPO3012	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YPO3013	COG4208	sulfate ABC transporter
YPO3014	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YPO3015	COG4150	thiosulfate binding
YPO3017	COG1737	Transcriptional regulator
YPO3019	COG2731	YhcH YjgK YiaL family protein
YPO3024	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YPO3025	COG2837	iron assimilation
YPO3027	COG3111	PFAM Bacterial OB fold (BOF) protein
YPO3036	COG3005	denitrification pathway
YPO3037	COG3043	anaerobic respiration
YPO3039	COG3062	negative regulation of establishment of protein localization
YPO3040	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPO3040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPO3041	COG2197	response regulator
YPO3043	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPO3045	COG1988	membrane-bound metal-dependent
YPO3046	COG0641	radical SAM
YPO3047	COG3119	arylsulfatase activity
YPO3048	COG3842	ATPase activity
YPO3049	COG1175	transmembrane transport
YPO3052	COG1393	Belongs to the ArsC family
YPO3054	COG1876	peptidase activity
YPO3058	COG2321	neutral zinc metallopeptidase
YPO3061	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YPO3063	COG2716	regulation of RNA biosynthetic process
YPO3064	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YPO3068	COG0628	permease
YPO3069	COG4783	chaperone-mediated protein folding
YPO3070	COG1393	Belongs to the ArsC family
YPO3074	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPO3076	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YPO3077	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YPO3078	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
YPO3079	COG4181	ATPase activity
YPO3080	COG2755	lipolytic protein G-D-S-L family
YPO3081	COG0300	oxidoreductase activity
YPO3082	COG3118	belongs to the thioredoxin family
YPO3083	COG0330	HflC and HflK could
YPO3084	COG1585	Membrane protein implicated in regulation of membrane protease activity
YPO3085	COG0789	Transcriptional regulator
YPO3086	COG2217	Heavy metal translocating P-type atpase
YPO3087	COG3735	TraB family
YPO3088	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YPO3093	COG2223	nitrite transmembrane transporter activity
YPO3094	COG4651	solute:proton antiporter activity
YPO3094	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPO3095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPO3096	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPO3112	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPO3116	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPO3116	COG0543	2 iron, 2 sulfur cluster binding
YPO3122	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YPO3126	COG2832	Protein of unknown function (DUF454)
YPO3129	COG3264	Mechanosensitive ion channel
YPO3129	COG1196	nuclear chromosome segregation
YPO3130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YPO3131	COG1309	transcriptional regulator
YPO3132	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPO3133	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPO3135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YPO3139	COG3695	enzyme binding
YPO3140	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YPO3141	COG1946	Acyl-CoA thioesterase
YPO3142	COG0004	ammonium transporteR
YPO3143	COG0347	Belongs to the P(II) protein family
YPO3144	COG1132	(ABC) transporter
YPO3145	COG1132	(ABC) transporter
YPO3146	COG1522	sequence-specific DNA binding
YPO3149	COG4533	DNA binding
YPO3151	COG0824	Thioesterase
YPO3152	COG1555	photosystem II stabilization
YPO3153	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPO3154	COG0776	regulation of translation
YPO3155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
YPO3160	COG0271	Belongs to the BolA IbaG family
YPO3161	COG3056	Lipoprotein
YPO3162	COG2223	nitrite transmembrane transporter activity
YPO3164	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YPO3165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YPO3166	COG1845	cytochrome c oxidase, subunit III
YPO3167	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YPO3169	COG2814	Major facilitator Superfamily
YPO3171	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YPO3172	COG0693	protein deglycase activity
YPO3176	COG0142	geranyltranstransferase activity
YPO3179	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YPO3180	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YPO3183	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPO3183	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPO3188	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPO3189	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPO3190	COG1862	Preprotein translocase
YPO3194	COG0450	alkyl hydroperoxide reductase
YPO3200	COG0366	Alpha amylase catalytic
YPO3204	COG5002	protein histidine kinase activity
YPO3205	COG0745	RESPONSE REGULATOR receiver
YPO3206	COG0420	3'-5' exonuclease activity
YPO3207	COG0419	ATPase involved in DNA repair
YPO3211	COG1940	carbohydrate kinase activity
YPO3218	COG2226	methyltransferase
YPO3228	COG0583	DNA-binding transcription factor activity
YPO3230	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPO3234	COG1477	protein flavinylation
YPO3238	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPO3239	COG1805	sodium ion transport
YPO3241	COG3034	peptidoglycan biosynthetic process
YPO3242	COG0121	glutamine amidotransferase
YPO3243	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
YPO3244	COG1960	acyl-CoA dehydrogenase activity
YPO3246	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YPO3255	COG0765	amino acid transport
YPO3263	COG2814	Major facilitator Superfamily
YPO3264	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YPO3266	COG1846	Transcriptional regulator
YPO3267	COG1566	PFAM secretion protein HlyD family protein
YPO3268	COG2814	Major facilitator Superfamily
YPO3269	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPO3270	COG3118	belongs to the thioredoxin family
YPO3271	COG3148	PFAM DTW domain containing protein
YPO3272	COG0045	succinate-CoA ligase (ADP-forming) activity
YPO3272	COG1042	CoA-binding domain protein
YPO3272	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPO3273	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPO3274	COG5544	Lipoprotein
YPO3275	COG0542	response to heat
YPO3277	COG0564	pseudouridine synthase activity
YPO3278	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPO3279	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YPO3285	COG1605	Chorismate mutase
YPO3285	COG0287	Prephenate dehydrogenase
YPO3286	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPO3287	COG3279	Response regulator of the LytR AlgR family
YPO3290	COG3137	Salt-induced outer membrane protein
YPO3296	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YPO3297	COG4137	Cytochrome C assembly protein
YPO3298	COG4536	flavin adenine dinucleotide binding
YPO3301	COG2918	glutathione biosynthetic process
YPO3302	COG1238	metal cluster binding
YPO3303	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPO3304	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YPO3312	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPO3313	COG3958	Transketolase
YPO3314	COG3959	Transketolase, thiamine diphosphate binding domain
YPO3315	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3316	COG1129	ABC transporter
YPO3318	COG1879	ABC-type sugar transport system periplasmic component
YPO3320	COG3783	Cytochrome b(562)
YPO3321	COG3038	cytochrome b561
YPO3322	COG3381	protein complex oligomerization
YPO3323	COG3302	dmso reductase anchor subunit
YPO3324	COG0437	4 iron, 4 sulfur cluster binding
YPO3325	COG0243	molybdopterin cofactor binding
YPO3326	COG0235	Class ii aldolase
YPO3327	COG1349	DNA-binding transcription factor activity
YPO3330	COG1129	ABC transporter
YPO3331	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3332	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3333	COG3623	hexulose-6-phosphate isomerase
YPO3334	COG1070	Carbohydrate kinase
YPO3335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YPO3335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YPO3337	COG0024	Methionine aminopeptidase
YPO3342	COG1858	cytochrome C peroxidase
YPO3343	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPO3347	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YPO3350	COG2376	Dihydroxyacetone kinase
YPO3351	COG1028	Short-chain dehydrogenase reductase Sdr
YPO3352	COG1063	alcohol dehydrogenase
YPO3353	COG0698	ribose 5-phosphate isomerase
YPO3355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPO3356	COG1388	LysM domain
YPO3356	COG4942	peptidase
YPO3364	COG0529	Catalyzes the synthesis of activated sulfate
YPO3373	COG0720	synthase
YPO3374	COG0602	queuosine metabolic process
YPO3378	COG3956	TIGRFAM MazG family protein
YPO3380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPO3381	COG4999	Histidine kinase
YPO3381	COG3850	Histidine kinase
YPO3381	COG2205	protein histidine kinase activity
YPO3381	COG3437	response regulator, receiver
YPO3382	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPO3386	COG2860	membrane
YPO3390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPO3391	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPO3392	COG1120	ATPase activity
YPO3393	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YPO3394	COG1643	Atp-dependent helicase
YPO3395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YPO3398	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YPO3399	COG0617	tRNA 3'-terminal CCA addition
YPO3400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YPO3404	COG0726	polysaccharide deacetylase
YPO3405	COG0842	Transport permease protein
YPO3406	COG1131	(ABC) transporter
YPO3407	COG0288	reversible hydration of carbon dioxide
YPO3408	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YPO3409	COG2132	Multicopper oxidase
YPO3413	COG0697	spore germination
YPO3415	COG1049	propionate catabolic process, 2-methylcitrate cycle
YPO3417	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPO3418	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPO3419	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YPO3420	COG2186	Transcriptional regulator
YPO3421	COG1113	amino acid transport
YPO3422	COG3725	Membrane protein required for beta-lactamase induction
YPO3423	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPO3425	COG4969	Belongs to the N-Me-Phe pilin family
YPO3426	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPO3427	COG1459	type II secretion system
YPO3438	COG0582	viral genome integration into host DNA
YPO3439	COG0795	lipopolysaccharide-transporting ATPase activity
YPO3440	COG0795	lipopolysaccharide-transporting ATPase activity
YPO3442	COG2927	DNA polymerase III (CHI subunit)
YPO3443	COG0525	valine-tRNA ligase activity
YPO3445	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YPO3447	COG2731	YhcH YjgK YiaL family protein
YPO3450	COG0601	transmembrane transport
YPO3451	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPO3452	COG0444	Belongs to the ABC transporter superfamily
YPO3456	COG2188	Transcriptional regulator
YPO3457	COG3624	Phosphonate C-P lyase system protein PhnG
YPO3458	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YPO3459	COG3626	phosphonate metabolism
YPO3460	COG3627	carbon phosphorus lyase activity
YPO3461	COG4107	phosphonate C-P lyase system protein PhnK
YPO3462	COG4778	phosphonate C-P lyase system protein PhnL
YPO3463	COG3454	Phosphonate metabolism
YPO3464	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YPO3465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YPO3466	COG0702	epimerase
YPO3469	COG3842	ATPase activity
YPO3470	COG0395	ABC-type sugar transport system, permease component
YPO3471	COG1175	transmembrane transport
YPO3472	COG1653	transport
YPO3476	COG3153	acetyltransferase
YPO3477	COG3154	lipid carrier protein
YPO3479	COG0826	peptidase U32
YPO3480	COG0826	peptidase U32
YPO3482	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPO3484	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YPO3488	COG0513	Belongs to the DEAD box helicase family
YPO3491	COG2801	Transposase and inactivated derivatives
YPO3497	COG0195	Participates in both transcription termination and antitermination
YPO3499	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YPO3501	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YPO3504	COG1534	Rna-binding protein
YPO3506	COG2027	D-alanyl-D-alanine carboxypeptidase
YPO3507	COG0745	RESPONSE REGULATOR receiver
YPO3508	COG0642	Histidine kinase
YPO3510	COG0697	spore germination
YPO3513	COG0142	geranyltranstransferase activity
YPO3514a	COG3423	Transcriptional regulator
YPO3519	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YPO3520	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YPO3521	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YPO3522	COG2105	PFAM AIG2 family protein
YPO3523	COG2911	Protein conserved in bacteria
YPO3524	COG0729	surface antigen
YPO3526	COG1253	flavin adenine dinucleotide binding
YPO3528	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YPO3530	COG0737	Belongs to the 5'-nucleotidase family
YPO3532	COG0545	Peptidyl-prolyl cis-trans isomerase
YPO3533	COG3061	Opacity-associated protein A
YPO3537	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YPO3539	COG0360	Binds together with S18 to 16S ribosomal RNA
YPO3541	COG1073	alpha beta
YPO3544	COG0435	Glutathione S-transferase
YPO3545	COG0583	DNA-binding transcription factor activity
YPO3546	COG1741	Belongs to the pirin family
YPO3547	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YPO3551	COG2823	Periplasmic or secreted lipoprotein
YPO3553	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YPO3555	COG5002	protein histidine kinase activity
YPO3555	COG0784	Response regulator, receiver
YPO3555	COG2198	Histidine kinase
YPO3556	COG1242	4 iron, 4 sulfur cluster binding
YPO3557	COG0070	glutamate synthase
YPO3557	COG0067	glutamate synthase
YPO3557	COG0069	glutamate synthase activity
YPO3558	COG0493	'glutamate synthase
YPO3560	COG2969	positive regulation of protein catabolic process
YPO3561	COG0625	glutathione transferase activity
YPO3564	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YPO3565	COG3105	Protein conserved in bacteria
YPO3566	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPO3568	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPO3570	COG5007	Belongs to the BolA IbaG family
YPO3571	COG3113	response to antibiotic
YPO3572	COG2854	intermembrane phospholipid transfer
YPO3573	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPO3574	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YPO3575	COG1127	ABC transporter
YPO3576	COG0530	calcium, potassium:sodium antiporter activity
YPO3577	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YPO3577	COG0517	IMP dehydrogenase activity
YPO3578	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YPO3579	COG3117	lipopolysaccharide transmembrane transporter activity
YPO3580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YPO3581	COG1137	ATPase activity
YPO3582	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YPO3587	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO3606	COG3501	Rhs element vgr protein
YPO3613	COG3501	Rhs element vgr protein
YPO3615	COG3209	COG3209 Rhs family protein
YPO3618	COG0673	inositol 2-dehydrogenase activity
YPO3619	COG1917	Cupin 2, conserved barrel domain protein
YPO3619	COG2207	Transcriptional regulator
YPO3620	COG1869	D-ribose catabolic process
YPO3621	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPO3622	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPO3623	COG0431	NADPH-dependent FMN reductase
YPO3624	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPO3626	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPO3629	COG2252	PERMEase
YPO3630	COG0025	NhaP-type Na H and K H
YPO3632	COG1560	Kdo2-lipid A biosynthetic process
YPO3634	COG1129	ABC transporter
YPO3635	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3637	COG1069	ribulokinase activity
YPO3639	COG0625	glutathione transferase activity
YPO3643	COG1278	Cold shock
YPO3644	COG1278	Cold shock
YPO3646	COG3133	Outer membrane lipoprotein
YPO3647	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPO3649	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPO3654	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YPO3655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPO3657	COG4145	pantothenate transmembrane transporter activity
YPO3657a	COG3924	membrane
YPO3658	COG0439	Biotin carboxylase
YPO3659	COG0511	ligase activity, forming carbon-carbon bonds
YPO3662	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YPO3663	COG0604	alcohol dehydrogenase
YPO3664	COG2200	EAL domain
YPO3664	COG2199	diguanylate cyclase activity
YPO3665	COG1077	Cell shape determining protein MreB Mrl
YPO3666	COG1792	Involved in formation and maintenance of cell shape
YPO3667	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YPO3668	COG0424	maF-like protein
YPO3669	COG1530	ribonuclease E activity
YPO3670	COG3164	Protein of unknown function
YPO3671	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPO3672	COG0312	modulator of DNA gyrase
YPO3683	COG0583	DNA-binding transcription factor activity
YPO3690	COG2732	(Barnase) inhibitor
YPO3692	COG0312	modulator of DNA gyrase
YPO3694	COG3783	Cytochrome b(562)
YPO3695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPO3696	COG0366	Alpha amylase catalytic
YPO3697	COG1263	PTS System
YPO3697	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPO3698	COG1609	Transcriptional regulator
YPO3703	COG2801	Transposase and inactivated derivatives
YPO3715	COG1175	transmembrane transport
YPO3716	COG3833	ABC-type maltose transport systems, permease component
YPO3719	COG0527	aspartate kinase activity
YPO3725	COG2224	Isocitrate lyase
YPO3726	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YPO3729	COG0151	Belongs to the GarS family
YPO3733	COG1515	deoxyribonuclease V activity
YPO3741	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YPO3742	COG2022	thiamine diphosphate biosynthetic process
YPO3752	COG0250	Participates in transcription elongation, termination and antitermination
YPO3760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YPO3761	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
YPO3762	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YPO3764a	COG1739	Uncharacterized protein family UPF0029
YPO3769	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
YPO3776	COG0805	protein transport
YPO3778	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YPO3782	COG1322	Protein conserved in bacteria
YPO3783	COG0586	Pfam SNARE associated Golgi protein
YPO3784	COG1966	Carbon starvation protein
YPO3787	COG0412	Dienelactone hydrolase
YPO3789	COG0583	DNA-binding transcription factor activity
YPO3790	COG0697	spore germination
YPO3791	COG0679	Auxin Efflux Carrier
YPO3792	COG0584	glycerophosphoryl diester phosphodiesterase
YPO3804	COG0410	ABC transporter
YPO3806	COG4177	L-phenylalanine transmembrane transporter activity
YPO3808	COG0683	leucine binding
YPO3812	COG2177	Part of the ABC transporter FtsEX involved in
YPO3813	COG2884	Cell division ATP-binding protein ftsE
YPO3814	COG0552	protein localization to endoplasmic reticulum
YPO3814	COG0552	protein localization to endoplasmic reticulum
YPO3816	COG0742	ribosomal rna small subunit methyltransferase
YPO3816a	COG3776	membrane
YPO3819	COG3714	YhhN family
YPO3822	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YPO3824	COG0247	lactate metabolic process
YPO3826	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPO3827	COG0584	glycerophosphoryl diester phosphodiesterase
YPO3829	COG0561	phosphatase activity
YPO3830	COG2267	carboxylic ester hydrolase activity
YPO3831	COG1280	lysine exporter protein (LysE YggA)
YPO3832	COG1280	lysine exporter protein (LysE YggA)
YPO3833	COG0514	ATP-dependent DNA helicase (RecQ)
YPO3834	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YPO3835	COG2050	protein possibly involved in aromatic compounds catabolism
YPO3838	COG5564	TIM-barrel signal transduction protein
YPO3839	COG5441	Belongs to the UPF0261 family
YPO3841	COG0210	DNA helicase
YPO3842	COG1011	Hydrolase
YPO3843	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YPO3844	COG3159	Protein conserved in bacteria
YPO3848	COG3072	Adenylate cyclase
YPO3850	COG1587	Uroporphyrinogen-III synthase
YPO3851	COG2959	enzyme of heme biosynthesis
YPO3852	COG3071	HemY protein
YPO3854	COG1113	amino acid transport
YPO3858	COG2244	polysaccharide biosynthetic process
YPO3859	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YPO3860	COG0456	acetyltransferase
YPO3861	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YPO3862	COG1088	dTDP-glucose 4,6-dehydratase activity
YPO3863	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YPO3864	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YPO3865	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPO3866	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YPO3867	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YPO3868	COG3118	belongs to the thioredoxin family
YPO3873	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPO3875	COG3328	transposase activity
YPO3878	COG3121	Chaperone
YPO3881	COG3121	Chaperone
YPO3889	COG0583	DNA-binding transcription factor activity
YPO3899	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPO3900	COG3978	acetolactate synthase activity
YPO3903	COG3085	chromosome segregation
YPO3905	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3906	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3907	COG1129	ABC transporter
YPO3908	COG1879	ABC-type sugar transport system periplasmic component
YPO3916	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPO3916	COG0678	peroxiredoxin activity
YPO3917	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPO3923	COG1629	transport
YPO3927	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YPO3932	COG2801	Transposase and inactivated derivatives
YPO3937	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPO3938	COG0058	SHG alpha-glucan phosphorylase activity
YPO3943	COG3275	phosphorelay sensor kinase activity
YPO3949	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPO3950	COG2095	MarC family integral membrane protein
YPO3953	COG3265	gluconokinase activity
YPO3954	COG2610	gluconate transmembrane transporter activity
YPO3955	COG1609	Transcriptional regulator
YPO3956	COG1741	Belongs to the pirin family
YPO3960	COG0191	fructose-bisphosphate aldolase activity
YPO3963	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPO3966	COG2081	HI0933 family
YPO3967	COG0306	phosphate transporter
YPO3970	COG0589	response to stress
YPO3975	COG0339	signal peptide processing
YPO3976	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YPO3977	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPO3978	COG3835	regulator
YPO3979	COG2610	gluconate transmembrane transporter activity
YPO3980	COG1929	Belongs to the glycerate kinase type-1 family
YPO3985	COG1295	ribonuclease BN
YPO3986	COG2134	cdp-diacylglycerol pyrophosphatase
YPO3987	COG2982	Protein involved in outer membrane biogenesis
YPO3988	COG2200	EAL domain
YPO3989	COG1942	4-Oxalocrotonate Tautomerase
YPO3990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPO3991	COG0612	Peptidase, M16
YPO3995	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPO3996	COG2200	EAL domain
YPO3996	COG2199	diguanylate cyclase activity
YPO3999	COG4608	Belongs to the ABC transporter superfamily
YPO4000	COG0444	Belongs to the ABC transporter superfamily
YPO4001	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPO4002	COG0601	transmembrane transport
YPO4003	COG0747	negative chemotaxis
YPO4005	COG2831	hemolysin activation secretion protein
YPO4007	COG2271	Major facilitator Superfamily
YPO4012	COG2197	response regulator
YPO4013	COG2194	sulfuric ester hydrolase activity
YPO4016	COG2986	histidine ammonia-lyase
YPO4022	COG4607	ABC-type enterochelin transport system periplasmic component
YPO4024	COG4605	iron ion homeostasis
YPO4025	COG4604	ABC transporter, ATP-binding protein
YPO4033	COG0582	viral genome integration into host DNA
YPO4034	COG2207	Transcriptional regulator
YPO4034	COG1609	Transcriptional regulator
YPO4035	COG4214	carbohydrate transport
YPO4037	COG4213	ABC transporter substrate-binding protein
YPO4039	COG1070	Carbohydrate kinase
YPO4041	COG3121	Chaperone
YPO4045	COG3274	enterobacterial common antigen metabolic process
YPO4047	COG2801	Transposase and inactivated derivatives
YPO4056	COG2864	formate dehydrogenase
YPO4057	COG0437	4 iron, 4 sulfur cluster binding
YPO4061	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPO4066	COG3722	fumarate hydratase activity
YPO4068	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPO4068	COG2213	PTS system mannitol-specific
YPO4074	COG2818	Glycosylase
YPO4076	COG2885	chlorophyll binding
YPO4080	COG0366	Alpha amylase catalytic
YPO4082	COG3977	Valine--pyruvate aminotransferase
YPO4086	COG5645	(Lipo)protein
YPO4089	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YPO4090	COG2423	ornithine cyclodeaminase activity
YPO4092	COG2801	Transposase and inactivated derivatives
YPO4093	COG0561	phosphatase activity
YPO4094	COG0187	DNA topoisomerase II activity
YPO4096	COG0592	DNA-directed DNA polymerase activity
YPO4100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YPO4102	COG0706	membrane insertase activity
YPO4103	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
YPO4107	COG2252	PERMEase
YPO4108	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPO4109	COG0765	amino acid transport
YPO4110	COG0765	amino acid transport
YPO4111	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPO4113	COG0704	Plays a role in the regulation of phosphate uptake
YPO4115	COG0581	inorganic phosphate transmembrane transporter activity
YPO4116	COG0573	inorganic phosphate transmembrane transporter activity
YPO4117	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YPO4128	COG3312	ion transport