locus-tag	class	description
YPD4_RS00005	COG0716	FMN binding
YPD4_RS00010	COG1522	sequence-specific DNA binding
YPD4_RS00040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_RS00050	COG0477	Major facilitator Superfamily
YPD4_RS00055	COG2186	Transcriptional regulator
YPD4_RS00085	COG3328	transposase activity
YPD4_RS00090	COG1763	Mo-molybdopterin cofactor biosynthetic process
YPD4_RS00100	COG3084	Protein conserved in bacteria
YPD4_RS00105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
YPD4_RS00115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD4_RS00115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
YPD4_RS00140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPD4_RS00150	COG3852	Histidine kinase
YPD4_RS00155	COG0174	glutamine synthetase
YPD4_RS00170	COG1011	Hydrolase
YPD4_RS00195	COG0456	acetyltransferase
YPD4_RS00200	COG2982	Protein involved in outer membrane biogenesis
YPD4_RS00210	COG0786	glutamate:sodium symporter activity
YPD4_RS00215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPD4_RS00220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD4_RS00225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPD4_RS00245	COG2860	membrane
YPD4_RS00250	COG1561	YicC-like family, N-terminal region
YPD4_RS00275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
YPD4_RS00310	COG1519	Transferase
YPD4_RS00315	COG0859	PFAM glycosyl transferase family 9
YPD4_RS00320	COG0859	PFAM glycosyl transferase family 9
YPD4_RS00330	COG0156	8-amino-7-oxononanoate synthase activity
YPD4_RS00345	COG4942	peptidase
YPD4_RS00355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPD4_RS00360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPD4_RS00380	COG1045	serine acetyltransferase
YPD4_RS00385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
YPD4_RS00390	COG2169	Transcriptional regulator
YPD4_RS00390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPD4_RS00395	COG2205	protein histidine kinase activity
YPD4_RS00400	COG0745	RESPONSE REGULATOR receiver
YPD4_RS00405	COG3678	ATP-independent chaperone mediated protein folding
YPD4_RS00425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
YPD4_RS00435	COG0471	metal ion transport
YPD4_RS00440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
YPD4_RS00445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
YPD4_RS00450	COG0583	DNA-binding transcription factor activity
YPD4_RS00465	COG3152	Membrane
YPD4_RS00475	COG1494	fructose-1,6-bisphosphatase
YPD4_RS00480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD4_RS00485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
YPD4_RS00535	COG1575	Belongs to the MenA family. Type 1 subfamily
YPD4_RS00550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
YPD4_RS00555	COG1609	Transcriptional regulator
YPD4_RS00565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
YPD4_RS00575	COG4682	membrane
YPD4_RS00595	COG0460	homoserine dehydrogenase
YPD4_RS00595	COG0527	aspartate kinase activity
YPD4_RS00605	COG2801	Transposase and inactivated derivatives
YPD4_RS00615	COG1349	DNA-binding transcription factor activity
YPD4_RS00625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
YPD4_RS00635	COG0058	SHG alpha-glucan phosphorylase activity
YPD4_RS00640	COG0058	SHG alpha-glucan phosphorylase activity
YPD4_RS00645	COG1640	4-alpha-glucanotransferase
YPD4_RS00680	COG1918	ferrous iron import across plasma membrane
YPD4_RS00690	COG2183	response to ionizing radiation
YPD4_RS00695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD4_RS00720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
YPD4_RS00725	COG1011	Hydrolase
YPD4_RS00740	COG0494	nUDIX hydrolase
YPD4_RS00745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
YPD4_RS00800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
YPD4_RS00805	COG0546	phosphoglycolate phosphatase activity
YPD4_RS00810	COG0180	Tryptophanyl-tRNA synthetase
YPD4_RS00830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
YPD4_RS00835	COG0402	S-adenosylhomocysteine deaminase activity
YPD4_RS00855	COG1486	melibiose metabolic process
YPD4_RS00860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPD4_RS00865	COG0433	COG0433 Predicted ATPase
YPD4_RS00880	COG1289	transmembrane transporter activity
YPD4_RS00890	COG1765	OsmC-like protein
YPD4_RS00900	COG3954	Phosphoribulokinase
YPD4_RS00910	COG0429	hydrolase of the alpha beta-hydrolase fold
YPD4_RS00920	COG4521	taurine ABC transporter
YPD4_RS00930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD4_RS00935	COG2175	clavaminate synthase activity
YPD4_RS00945	COG1216	Glycosyl transferase, family 2
YPD4_RS00965	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
YPD4_RS00970	COG1047	Peptidyl-prolyl cis-trans
YPD4_RS00980	COG0545	Peptidyl-prolyl cis-trans isomerase
YPD4_RS00985	COG2964	Protein conserved in bacteria
YPD4_RS01005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
YPD4_RS01010	COG0049	tRNA binding
YPD4_RS01040	COG0051	transcription antitermination factor activity, RNA binding
YPD4_RS01055	COG0089	rRNA binding
YPD4_RS01065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YPD4_RS01075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
YPD4_RS01080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
YPD4_RS01090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
YPD4_RS01095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
YPD4_RS01135	COG1841	ribosomal large subunit assembly
YPD4_RS01150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YPD4_RS01165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
YPD4_RS01180	COG0789	Transcriptional regulator
YPD4_RS01185	COG3036	rescue of stalled ribosome
YPD4_RS01215	COG0758	DNA mediated transformation
YPD4_RS01225	COG0551	DNA topoisomerase type I activity
YPD4_RS01240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
YPD4_RS01265	COG3162	membrane
YPD4_RS01275	COG1301	dicarboxylic acid transport
YPD4_RS01385	COG2391	methyltransferase activity
YPD4_RS01390	COG0425	Belongs to the sulfur carrier protein TusA family
YPD4_RS01395	COG0583	DNA-binding transcription factor activity
YPD4_RS01400	COG0814	amino acid
YPD4_RS01405	COG0626	cystathionine gamma-synthase activity
YPD4_RS01415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_RS01420	COG4558	Periplasmic binding protein
YPD4_RS01425	COG3720	iron ion transport
YPD4_RS01435	COG0702	epimerase
YPD4_RS01440	COG3721	Heme iron utilization protein
YPD4_RS01465	COG1358	cellular component organization or biogenesis
YPD4_RS01525	COG3121	Chaperone
YPD4_RS01570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
YPD4_RS01580	COG0735	belongs to the Fur family
YPD4_RS01585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD4_RS01610	COG1448	Aminotransferase
YPD4_RS01615	COG2315	Protein conserved in bacteria
YPD4_RS01620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YPD4_RS01625	COG0629	single-stranded DNA binding
YPD4_RS01635	COG1454	alcohol dehydrogenase
YPD4_RS01705	COG1309	transcriptional regulator
YPD4_RS01710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_RS01710	COG0493	'glutamate synthase
YPD4_RS01715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_RS01720	COG3383	formate dehydrogenase (NAD+) activity
YPD4_RS01735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_RS01780	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
YPD4_RS01790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
YPD4_RS01795	COG1053	succinate dehydrogenase
YPD4_RS01810	COG3264	Mechanosensitive ion channel
YPD4_RS01810	COG1511	domain protein
YPD4_RS01830	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
YPD4_RS01850	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
YPD4_RS01855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
YPD4_RS01855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
YPD4_RS01860	COG0802	atpase or kinase
YPD4_RS01865	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPD4_RS01885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
YPD4_RS01890	COG0330	HflC and HflK could
YPD4_RS01895	COG0330	HflC and HflK could
YPD4_RS01900	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
YPD4_RS01920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD4_RS01925	COG1960	acyl-CoA dehydrogenase activity
YPD4_RS01930	COG3650	response to hydrogen peroxide
YPD4_RS01950	COG1401	restriction endodeoxyribonuclease activity
YPD4_RS01965	COG2963	transposase activity
YPD4_RS02020	COG4269	membrane
YPD4_RS02030	COG2207	Transcriptional regulator
YPD4_RS02035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_RS02040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_RS02045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_RS02050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPD4_RS02050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_RS02050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_RS02100	COG1070	Carbohydrate kinase
YPD4_RS02105	COG0859	PFAM glycosyl transferase family 9
YPD4_RS02125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_RS02130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_RS02175	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
YPD4_RS02180	COG0456	acetyltransferase
YPD4_RS02190	COG2823	Periplasmic or secreted lipoprotein
YPD4_RS02200	COG4667	esterase of the alpha-beta hydrolase superfamily
YPD4_RS02205	COG0084	hydrolase, TatD family'
YPD4_RS02210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPD4_RS02240	COG3726	membrane protein affecting hemolysin expression
YPD4_RS02245	COG0560	Phosphoserine phosphatase
YPD4_RS02270	COG2885	chlorophyll binding
YPD4_RS02275	COG2199	diguanylate cyclase activity
YPD4_RS02290	COG0741	lytic transglycosylase activity
YPD4_RS02295	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
YPD4_RS02310	COG3708	Transcriptional regulator
YPD4_RS02310	COG2207	Transcriptional regulator
YPD4_RS02315	COG3045	CreA protein
YPD4_RS02320	COG0745	RESPONSE REGULATOR receiver
YPD4_RS02350	COG0521	Mo-molybdopterin cofactor biosynthetic process
YPD4_RS02365	COG1584	GPR1 FUN34 yaaH family protein
YPD4_RS02385	COG0583	DNA-binding transcription factor activity
YPD4_RS02400	COG0196	riboflavin kinase activity
YPD4_RS02415	COG1047	Peptidyl-prolyl cis-trans
YPD4_RS02450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
YPD4_RS02455	COG1280	lysine exporter protein (LysE YggA)
YPD4_RS02460	COG2966	Psort location CytoplasmicMembrane, score
YPD4_RS02470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
YPD4_RS02525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
YPD4_RS02530	COG0564	pseudouridine synthase activity
YPD4_RS02620	COG2885	chlorophyll binding
YPD4_RS02620	COG3047	cAMP biosynthetic process
YPD4_RS02640	COG0417	DNA replication proofreading
YPD4_RS02645	COG0586	Pfam SNARE associated Golgi protein
YPD4_RS02650	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
YPD4_RS02655	COG1178	ABC-type Fe3 transport system permease component
YPD4_RS02660	COG4143	(ABC) transporter
YPD4_RS02680	COG2814	Major facilitator Superfamily
YPD4_RS02695	COG2814	Major facilitator Superfamily
YPD4_RS02710	COG0473	3-isopropylmalate dehydrogenase activity
YPD4_RS02745	COG1022	Amp-dependent synthetase and ligase
YPD4_RS02755	COG0028	Belongs to the TPP enzyme family
YPD4_RS02775	COG1609	Transcriptional regulator
YPD4_RS02795	COG3116	cell division
YPD4_RS02800	COG0768	penicillin binding
YPD4_RS02805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
YPD4_RS02810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
YPD4_RS02825	COG0772	Belongs to the SEDS family
YPD4_RS02845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
YPD4_RS02850	COG0849	cell division
YPD4_RS02855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
YPD4_RS02880	COG0494	nUDIX hydrolase
YPD4_RS02895	COG0435	Glutathione S-transferase
YPD4_RS02900	COG2259	Doxx family
YPD4_RS02910	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
YPD4_RS02915	COG4575	ribosome binding
YPD4_RS02935	COG0586	Pfam SNARE associated Golgi protein
YPD4_RS02950	COG2271	Major facilitator Superfamily
YPD4_RS02990	COG0673	inositol 2-dehydrogenase activity
YPD4_RS02995	COG1451	nucleotide metabolic process
YPD4_RS03010	COG0446	pyridine nucleotide-disulphide oxidoreductase
YPD4_RS03010	COG1902	pentaerythritol trinitrate reductase activity
YPD4_RS03015	COG3247	response to pH
YPD4_RS03035	COG4245	von Willebrand factor, type A
YPD4_RS03050	COG4245	von Willebrand factor, type A
YPD4_RS03055	COG2831	hemolysin activation secretion protein
YPD4_RS03085	COG3210	domain, Protein
YPD4_RS03090	COG3210	domain, Protein
YPD4_RS03110	COG3842	ATPase activity
YPD4_RS03115	COG3459	Glycosyltransferase 36 associated
YPD4_RS03120	COG1609	Transcriptional regulator
YPD4_RS03125	COG2182	Extracellular solute-binding protein
YPD4_RS03135	COG0395	ABC-type sugar transport system, permease component
YPD4_RS03155	COG1289	transmembrane transporter activity
YPD4_RS03180	COG0436	Aminotransferase
YPD4_RS03200	COG0251	oxidation-reduction process
YPD4_RS03290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
YPD4_RS03305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
YPD4_RS03320	COG4991	sh3 domain protein
YPD4_RS03325	COG3025	triphosphatase activity
YPD4_RS03360	COG3384	dioxygenase
YPD4_RS03380	COG1538	Outer membrane efflux protein
YPD4_RS03385	COG0494	nUDIX hydrolase
YPD4_RS03390	COG3151	Protein conserved in bacteria
YPD4_RS03395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
YPD4_RS03400	COG3150	esterase
YPD4_RS03410	COG0583	DNA-binding transcription factor activity
YPD4_RS03415	COG2249	NAD(P)H dehydrogenase (quinone) activity
YPD4_RS03420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
YPD4_RS03430	COG2132	Multicopper oxidase
YPD4_RS03440	COG0656	L-ascorbic acid biosynthetic process
YPD4_RS03450	COG1979	alcohol dehydrogenase
YPD4_RS03455	COG2207	Transcriptional regulator
YPD4_RS03460	COG0586	Pfam SNARE associated Golgi protein
YPD4_RS03465	COG0626	cystathionine gamma-synthase activity
YPD4_RS03470	COG0811	peptide transport
YPD4_RS03475	COG0848	biopolymer transport protein
YPD4_RS03525	COG4964	Belongs to the GSP D family
YPD4_RS03530	COG4964	Belongs to the GSP D family
YPD4_RS03575	COG4592	Periplasmic binding protein
YPD4_RS03595	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD4_RS03600	COG1684	flagellar biosynthetic protein fliR
YPD4_RS03605	COG1987	bacterial-type flagellum assembly
YPD4_RS03630	COG1677	Flagellar hook-basal body complex protein FliE
YPD4_RS03670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
YPD4_RS03675	COG1815	bacterial-type flagellum-dependent cell motility
YPD4_RS03680	COG1558	bacterial-type flagellum-dependent cell motility
YPD4_RS03685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
YPD4_RS03690	COG1749	Flagellar hook protein flgE
YPD4_RS03715	COG4786	Flagellar basal body rod
YPD4_RS03725	COG1706	bacterial-type flagellum-dependent cell motility
YPD4_RS03735	COG1256	bacterial-type flagellum assembly
YPD4_RS03755	COG3710	Transcriptional regulator
YPD4_RS03775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
YPD4_RS03800	COG1191	sigma factor activity
YPD4_RS03805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
YPD4_RS03865	COG0471	metal ion transport
YPD4_RS03880	COG3209	COG3209 Rhs family protein
YPD4_RS03890	COG3501	Rhs element vgr protein
YPD4_RS03910	COG2610	gluconate transmembrane transporter activity
YPD4_RS03925	COG1132	(ABC) transporter
YPD4_RS03930	COG1132	(ABC) transporter
YPD4_RS03930	COG2375	cellular response to nickel ion
YPD4_RS03955	COG3433	isochorismatase activity
YPD4_RS03955	COG2226	methyltransferase
YPD4_RS03955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_RS03965	COG3433	isochorismatase activity
YPD4_RS03965	COG2226	methyltransferase
YPD4_RS03965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_RS03985	COG4771	TonB-dependent receptor
YPD4_RS03990	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPD4_RS03995	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
YPD4_RS04035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_RS04045	COG5001	Diguanylate cyclase
YPD4_RS04050	COG2801	Transposase and inactivated derivatives
YPD4_RS04060	COG2211	Major facilitator Superfamily
YPD4_RS04110	COG2771	luxR family
YPD4_RS04115	COG3916	Acyl-homoserine-lactone synthase
YPD4_RS04220	COG1982	Orn Lys Arg decarboxylase major
YPD4_RS04225	COG1879	ABC-type sugar transport system periplasmic component
YPD4_RS04230	COG1129	ABC transporter
YPD4_RS04235	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS04240	COG4774	siderophore transport
YPD4_RS04260	COG1194	a g-specific adenine glycosylase
YPD4_RS04270	COG3171	Protein conserved in bacteria
YPD4_RS04290	COG3064	Membrane
YPD4_RS04290	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
YPD4_RS04290	COG1073	alpha beta
YPD4_RS04295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
YPD4_RS04310	COG0762	integral membrane protein
YPD4_RS04315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
YPD4_RS04320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
YPD4_RS04325	COG2805	Type II/IV secretion system protein
YPD4_RS04335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD4_RS04350	COG0189	ligase activity
YPD4_RS04355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
YPD4_RS04360	COG2356	endonuclease I
YPD4_RS04375	COG1166	arginine decarboxylase activity
YPD4_RS04385	COG0501	Belongs to the peptidase M48B family
YPD4_RS04390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
YPD4_RS04410	COG0191	fructose-bisphosphate aldolase activity
YPD4_RS04445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
YPD4_RS04450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
YPD4_RS04465	COG0006	proline dipeptidase activity
YPD4_RS04470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD4_RS04475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD4_RS04505	COG5295	Hep Hag repeat protein
YPD4_RS04515	COG1272	protein, Hemolysin III
YPD4_RS04540	COG0745	RESPONSE REGULATOR receiver
YPD4_RS04545	COG2205	protein histidine kinase activity
YPD4_RS04550	COG4452	Inner membrane protein CreD
YPD4_RS04555	COG0716	FMN binding
YPD4_RS04560	COG4974	Belongs to the 'phage' integrase family
YPD4_RS04565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
YPD4_RS04570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
YPD4_RS04590	COG0582	viral genome integration into host DNA
YPD4_RS04620	COG2944	sequence-specific DNA binding
YPD4_RS04715	COG1695	Transcriptional regulator
YPD4_RS04720	COG0791	NLP P60 protein
YPD4_RS04730	COG1879	ABC-type sugar transport system periplasmic component
YPD4_RS04735	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS04740	COG1129	ABC transporter
YPD4_RS04750	COG2182	Extracellular solute-binding protein
YPD4_RS04755	COG1175	transmembrane transport
YPD4_RS04765	COG3867	Arabinogalactan endo-beta-1,4-galactanase
YPD4_RS04770	COG1874	Beta-galactosidase
YPD4_RS04775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_RS04775	COG1263	PTS System
YPD4_RS04795	COG2271	Major facilitator Superfamily
YPD4_RS04825	COG3119	arylsulfatase activity
YPD4_RS04830	COG0641	radical SAM
YPD4_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS04850	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_RS04855	COG3716	PTS system mannose fructose sorbose family IID component
YPD4_RS04860	COG3715	PTS system
YPD4_RS04865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_RS04870	COG2222	sugar isomerase
YPD4_RS04880	COG1349	DNA-binding transcription factor activity
YPD4_RS04885	COG3119	arylsulfatase activity
YPD4_RS04930	COG0288	reversible hydration of carbon dioxide
YPD4_RS04950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPD4_RS05020	COG0840	transmembrane signaling receptor activity
YPD4_RS05035	COG0583	DNA-binding transcription factor activity
YPD4_RS05040	COG2814	Major facilitator Superfamily
YPD4_RS05045	COG0583	DNA-binding transcription factor activity
YPD4_RS05055	COG1609	Transcriptional regulator
YPD4_RS05085	COG0667	Aldo Keto reductase
YPD4_RS05160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
YPD4_RS05175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
YPD4_RS05185	COG0860	N-Acetylmuramoyl-L-alanine amidase
YPD4_RS05200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
YPD4_RS05205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
YPD4_RS05210	COG2166	iron-sulfur cluster assembly
YPD4_RS05215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
YPD4_RS05220	COG0583	DNA-binding transcription factor activity
YPD4_RS05225	COG2363	Small membrane protein
YPD4_RS05240	COG1611	Belongs to the LOG family
YPD4_RS05260	COG3098	single-species biofilm formation
YPD4_RS05265	COG0564	pseudouridine synthase activity
YPD4_RS05325	COG0575	Belongs to the CDS family
YPD4_RS05330	COG0750	zinc metalloprotease
YPD4_RS05345	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
YPD4_RS05370	COG0587	DNA-directed DNA polymerase activity
YPD4_RS05380	COG0346	lactoylglutathione lyase activity
YPD4_RS05385	COG0037	tRNA processing
YPD4_RS05395	COG4568	rho-dependent transcription termination
YPD4_RS05405	COG4681	YaeQ
YPD4_RS05415	COG3015	lipoprotein NlpE involved in copper resistance
YPD4_RS05425	COG1720	tRNA m6t6A37 methyltransferase activity
YPD4_RS05435	COG1464	Belongs to the NlpA lipoprotein family
YPD4_RS05440	COG2011	ABC-type metal ion transport system permease component
YPD4_RS05450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPD4_RS05485	COG0656	L-ascorbic acid biosynthetic process
YPD4_RS05500	COG1388	LysM domain
YPD4_RS05500	COG0741	lytic transglycosylase activity
YPD4_RS05505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPD4_RS05510	COG2226	methyltransferase
YPD4_RS05530	COG1953	Uracil, thiamine, allantoin
YPD4_RS05560	COG3657	addiction module killer protein
YPD4_RS05620	COG0582	viral genome integration into host DNA
YPD4_RS05640	COG2867	negative regulation of translational initiation
YPD4_RS05650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD4_RS05655	COG0497	DNA recombination
YPD4_RS05660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
YPD4_RS05675	COG2009	succinate dehydrogenase
YPD4_RS05680	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
YPD4_RS05685	COG1053	succinate dehydrogenase
YPD4_RS05695	COG0567	Dehydrogenase, E1 component
YPD4_RS05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPD4_RS05710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
YPD4_RS05715	COG1271	oxidase subunit
YPD4_RS05720	COG1294	oxidase, subunit
YPD4_RS05725	COG4890	Cyd operon protein YbgT
YPD4_RS05730	COG3790	cyd operon protein YbgE
YPD4_RS05735	COG0824	Thioesterase
YPD4_RS05740	COG0811	peptide transport
YPD4_RS05745	COG0848	biopolymer transport protein
YPD4_RS05750	COG3064	Membrane
YPD4_RS05750	COG3064	Membrane
YPD4_RS05760	COG2885	chlorophyll binding
YPD4_RS05765	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
YPD4_RS05815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
YPD4_RS05830	COG2017	converts alpha-aldose to the beta-anomer
YPD4_RS05845	COG1085	galactose-1-phosphate uridylyltransferase
YPD4_RS05850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
YPD4_RS05865	COG1119	ATPase activity
YPD4_RS05870	COG3585	molybdate ion transport
YPD4_RS05870	COG2005	Transcriptional regulator
YPD4_RS05880	COG0725	ABC transporter, periplasmic molybdate-binding protein
YPD4_RS05885	COG4149	molybdate abc transporter
YPD4_RS05895	COG0561	phosphatase activity
YPD4_RS05920	COG2226	methyltransferase
YPD4_RS05930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
YPD4_RS05940	COG4628	conserved protein (DUF2132)
YPD4_RS05945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
YPD4_RS05955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
YPD4_RS05965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
YPD4_RS05970	COG0314	molybdopterin synthase activity
YPD4_RS05975	COG0670	Belongs to the BI1 family
YPD4_RS06005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPD4_RS06010	COG0583	DNA-binding transcription factor activity
YPD4_RS06020	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
YPD4_RS06025	COG2211	Major facilitator Superfamily
YPD4_RS06035	COG2211	Major facilitator Superfamily
YPD4_RS06055	COG1902	pentaerythritol trinitrate reductase activity
YPD4_RS06075	COG0842	Transport permease protein
YPD4_RS06080	COG0842	Transport permease protein
YPD4_RS06085	COG1131	(ABC) transporter
YPD4_RS06095	COG1309	transcriptional regulator
YPD4_RS06100	COG0513	Belongs to the DEAD box helicase family
YPD4_RS06140	COG0513	Belongs to the DEAD box helicase family
YPD4_RS06160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD4_RS06170	COG1686	Belongs to the peptidase S11 family
YPD4_RS06175	COG0277	FAD linked oxidase domain protein
YPD4_RS06195	COG2261	transglycosylase associated protein
YPD4_RS06205	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
YPD4_RS06220	COG4807	Protein conserved in bacteria
YPD4_RS06240	COG1122	ATPase activity
YPD4_RS06260	COG2897	thiosulfate sulfurtransferase activity
YPD4_RS06265	COG1732	Glycine betaine
YPD4_RS06270	COG1732	Glycine betaine
YPD4_RS06275	COG1174	glycine betaine transport
YPD4_RS06280	COG1125	glycine betaine transport
YPD4_RS06285	COG1174	glycine betaine transport
YPD4_RS06290	COG0531	amino acid
YPD4_RS06295	COG1982	Orn Lys Arg decarboxylase major
YPD4_RS06305	COG0697	spore germination
YPD4_RS06330	COG0814	amino acid
YPD4_RS06345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_RS06375	COG0784	Response regulator, receiver
YPD4_RS06375	COG2205	protein histidine kinase activity
YPD4_RS06385	COG2198	Histidine kinase
YPD4_RS06385	COG0642	Histidine kinase
YPD4_RS06390	COG2198	Histidine kinase
YPD4_RS06390	COG0642	Histidine kinase
YPD4_RS06395	COG2223	nitrite transmembrane transporter activity
YPD4_RS06425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
YPD4_RS06470	COG3395	kinase activity
YPD4_RS06480	COG1349	DNA-binding transcription factor activity
YPD4_RS06485	COG3622	Belongs to the hyi family
YPD4_RS06505	COG4386	tail sheath protein
YPD4_RS06545	COG3299	homolog of phage Mu protein gp47
YPD4_RS06565	COG1737	Transcriptional regulator
YPD4_RS06570	COG2723	6-phospho-beta-galactosidase activity
YPD4_RS06590	COG3157	Type VI secretion system effector, Hcp
YPD4_RS06605	COG3083	sulfuric ester hydrolase activity
YPD4_RS06610	COG3082	Protein of unknown function (DUF1414)
YPD4_RS06635	COG1061	Type III restriction enzyme res subunit
YPD4_RS06640	COG1187	pseudouridine synthase activity
YPD4_RS06645	COG2814	Major facilitator Superfamily
YPD4_RS06655	COG4172	Belongs to the ABC transporter superfamily
YPD4_RS06660	COG4239	(ABC) transporter, permease
YPD4_RS06665	COG4174	ABC transporter (Permease)
YPD4_RS06670	COG4166	transmembrane transport
YPD4_RS06675	COG2200	EAL domain
YPD4_RS06680	COG0791	NLP P60 protein
YPD4_RS06685	COG0671	phosphoesterase, PA-phosphatase related
YPD4_RS06690	COG0523	cobalamin synthesis protein
YPD4_RS06700	COG2186	Transcriptional regulator
YPD4_RS06705	COG0246	Mannitol dehydrogenase
YPD4_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS06765	COG1129	ABC transporter
YPD4_RS06775	COG0494	nUDIX hydrolase
YPD4_RS06785	COG1105	Belongs to the carbohydrate kinase PfkB family
YPD4_RS06790	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
YPD4_RS06790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_RS06790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
YPD4_RS06795	COG3710	Transcriptional regulator
YPD4_RS06810	COG3121	Chaperone
YPD4_RS06815	COG3188	usher protein
YPD4_RS06835	COG0833	amino acid
YPD4_RS06845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_RS06855	COG4771	TonB-dependent receptor
YPD4_RS06860	COG0625	glutathione transferase activity
YPD4_RS06885	COG2011	ABC-type metal ion transport system permease component
YPD4_RS06890	COG1686	Belongs to the peptidase S11 family
YPD4_RS06900	COG0814	amino acid
YPD4_RS06905	COG1349	DNA-binding transcription factor activity
YPD4_RS06915	COG0671	phosphoesterase, PA-phosphatase related
YPD4_RS06950	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
YPD4_RS06955	COG3842	ATPase activity
YPD4_RS06960	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD4_RS06965	COG1177	transmembrane transport
YPD4_RS06980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS07010	COG1120	ATPase activity
YPD4_RS07035	COG4160	amino acid transport
YPD4_RS07040	COG4215	(ABC) transporter
YPD4_RS07045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS07050	COG1126	abc transporter atp-binding protein
YPD4_RS07055	COG1605	Chorismate mutase
YPD4_RS07065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_RS07070	COG0702	epimerase
YPD4_RS07075	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
YPD4_RS07080	COG0028	Belongs to the TPP enzyme family
YPD4_RS07085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_RS07095	COG2431	L-lysine efflux transmembrane transporter activity
YPD4_RS07100	COG3593	DNA synthesis involved in DNA repair
YPD4_RS07105	COG2990	Protein conserved in bacteria
YPD4_RS07110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_RS07120	COG1278	Cold shock
YPD4_RS07130	COG0542	response to heat
YPD4_RS07140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
YPD4_RS07150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
YPD4_RS07165	COG0492	ferredoxin-NADP+ reductase activity
YPD4_RS07175	COG1674	ftsk spoiiie
YPD4_RS07175	COG3107	peptidoglycan biosynthetic process
YPD4_RS07185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
YPD4_RS07200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
YPD4_RS07215	COG2116	formate transmembrane transporter activity
YPD4_RS07220	COG1944	ATP diphosphatase activity
YPD4_RS07225	COG0252	asparaginase activity
YPD4_RS07230	COG5295	Hep Hag repeat protein
YPD4_RS07230	COG5295	Hep Hag repeat protein
YPD4_RS07255	COG0539	negative regulation of cytoplasmic translation
YPD4_RS07270	COG2333	competence protein COMEC
YPD4_RS07270	COG0658	competence protein
YPD4_RS07285	COG5383	Protein conserved in bacteria
YPD4_RS07295	COG1278	Cold shock
YPD4_RS07310	COG3173	Aminoglycoside phosphotransferase
YPD4_RS07320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
YPD4_RS07355	COG3108	Peptidase M15
YPD4_RS07365	COG1448	Aminotransferase
YPD4_RS07400	COG3217	Mosc domain protein beta barrel domain protein
YPD4_RS07400	COG0633	Ferredoxin
YPD4_RS07410	COG0488	(ABC) transporter
YPD4_RS07415	COG2995	paraquat-inducible protein a
YPD4_RS07420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPD4_RS07420	COG3008	intermembrane lipid transfer
YPD4_RS07425	COG3009	Protein conserved in bacteria
YPD4_RS07435	COG3130	regulation of translation
YPD4_RS07450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_RS07465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_RS07480	COG1067	ATP-dependent peptidase activity
YPD4_RS07510	COG3070	regulator of competence-specific genes
YPD4_RS07515	COG1289	transmembrane transporter activity
YPD4_RS07520	COG3304	Inner membrane component domain
YPD4_RS07525	COG0210	DNA helicase
YPD4_RS07540	COG1832	CoA-binding protein
YPD4_RS07560	COG2920	part of a sulfur-relay system
YPD4_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS07605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
YPD4_RS07610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS07620	COG3425	synthase
YPD4_RS07630	COG1024	Enoyl-CoA hydratase
YPD4_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
YPD4_RS07650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
YPD4_RS07815	COG0488	(ABC) transporter
YPD4_RS07825	COG3328	transposase activity
YPD4_RS07835	COG0303	'Molybdopterin
YPD4_RS07845	COG1136	(ABC) transporter
YPD4_RS07880	COG0583	DNA-binding transcription factor activity
YPD4_RS07885	COG0477	Major facilitator Superfamily
YPD4_RS07895	COG2311	Membrane
YPD4_RS07910	COG4211	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS07915	COG2949	membrane
YPD4_RS07930	COG1346	cytolysis
YPD4_RS07940	COG2814	Major facilitator Superfamily
YPD4_RS07975	COG0489	protein tyrosine kinase activity
YPD4_RS07990	COG2982	Protein involved in outer membrane biogenesis
YPD4_RS07995	COG1253	flavin adenine dinucleotide binding
YPD4_RS08000	COG4114	ferric iron reductase
YPD4_RS08005	COG0076	glutamate decarboxylase activity
YPD4_RS08010	COG3486	L-lysine 6-monooxygenase (NADPH) activity
YPD4_RS08025	COG1120	ATPase activity
YPD4_RS08030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_RS08035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_RS08040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPD4_RS08055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPD4_RS08060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
YPD4_RS08070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
YPD4_RS08070	COG0140	phosphoribosyl-ATP diphosphatase activity
YPD4_RS08090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
YPD4_RS08090	COG0131	Imidazoleglycerol-phosphate dehydratase
YPD4_RS08100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
YPD4_RS08110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_RS08120	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS08125	COG1129	ABC transporter
YPD4_RS08130	COG1129	ABC transporter
YPD4_RS08135	COG0371	Dehydrogenase
YPD4_RS08145	COG0531	amino acid
YPD4_RS08150	COG2925	Exonuclease
YPD4_RS08165	COG3328	transposase activity
YPD4_RS08170	COG1470	cell adhesion involved in biofilm formation
YPD4_RS08170	COG1388	LysM domain
YPD4_RS08175	COG2271	Major facilitator Superfamily
YPD4_RS08180	COG3011	Protein conserved in bacteria
YPD4_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS08195	COG4948	Mandelate Racemase Muconate Lactonizing
YPD4_RS08210	COG0534	Mate efflux family protein
YPD4_RS08230	COG3122	Protein conserved in bacteria
YPD4_RS08255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
YPD4_RS08275	COG2223	nitrite transmembrane transporter activity
YPD4_RS08280	COG3328	transposase activity
YPD4_RS08285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_RS08295	COG3001	Fructosamine kinase
YPD4_RS08305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD4_RS08310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD4_RS08315	COG1121	(ABC) transporter
YPD4_RS08320	COG0803	Belongs to the bacterial solute-binding protein 9 family
YPD4_RS08345	COG4249	Peptidase C14 caspase catalytic subunit p20
YPD4_RS08375	COG0072	phenylalanine-tRNA ligase activity
YPD4_RS08375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
YPD4_RS08380	COG0776	regulation of translation
YPD4_RS08395	COG0386	Belongs to the glutathione peroxidase family
YPD4_RS08440	COG0791	NLP P60 protein
YPD4_RS08465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
YPD4_RS08465	COG0574	Belongs to the PEP-utilizing enzyme family
YPD4_RS08470	COG0628	permease
YPD4_RS08475	COG0277	FAD linked oxidase domain protein
YPD4_RS08475	COG0247	lactate metabolic process
YPD4_RS08480	COG2050	protein possibly involved in aromatic compounds catabolism
YPD4_RS08490	COG0316	Belongs to the HesB IscA family
YPD4_RS08495	COG0719	Fe-S assembly protein
YPD4_RS08500	COG0396	ATPase activity
YPD4_RS08505	COG0719	Fe-S assembly protein
YPD4_RS08520	COG1376	ErfK ybiS ycfS ynhG family protein
YPD4_RS08520	COG1388	LysM domain
YPD4_RS08570	COG0307	riboflavin synthase, alpha
YPD4_RS08575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
YPD4_RS08580	COG2814	Major facilitator Superfamily
YPD4_RS08585	COG0583	DNA-binding transcription factor activity
YPD4_RS08600	COG0791	NLP P60 protein
YPD4_RS08610	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
YPD4_RS08615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
YPD4_RS08620	COG0346	lactoylglutathione lyase activity
YPD4_RS08630	COG1902	pentaerythritol trinitrate reductase activity
YPD4_RS08635	COG1309	transcriptional regulator
YPD4_RS08640	COG2194	sulfuric ester hydrolase activity
YPD4_RS08645	COG3313	Fe-S protein
YPD4_RS08650	COG4989	oxidoreductase activity
YPD4_RS08660	COG3133	Outer membrane lipoprotein
YPD4_RS08670	COG3895	Periplasmic Protein
YPD4_RS08690	COG0625	glutathione transferase activity
YPD4_RS08705	COG3104	oligopeptide transport
YPD4_RS08710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD4_RS08710	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD4_RS08715	COG4172	Belongs to the ABC transporter superfamily
YPD4_RS08725	COG4171	peptide transport system, permease
YPD4_RS08730	COG4168	peptide transport system, permease
YPD4_RS08735	COG4166	transmembrane transport
YPD4_RS08755	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
YPD4_RS08760	COG1842	Phage shock protein A
YPD4_RS08770	COG1983	PspC domain protein
YPD4_RS08790	COG5654	RES domain protein
YPD4_RS08795	COG5642	Protein of unknown function (DUF2384)
YPD4_RS08810	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
YPD4_RS08845	COG3121	Chaperone
YPD4_RS08865	COG3008	intermembrane lipid transfer
YPD4_RS08870	COG2995	paraquat-inducible protein a
YPD4_RS08875	COG1956	GAF domain-containing protein
YPD4_RS08885	COG0793	Belongs to the peptidase S41A family
YPD4_RS08895	COG3539	Fimbrial protein
YPD4_RS08900	COG3121	Chaperone
YPD4_RS08915	COG3121	Chaperone
YPD4_RS08925	COG0823	Involved in the tonB-independent uptake of proteins
YPD4_RS08935	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD4_RS08940	COG1823	symporter activity
YPD4_RS08945	COG1988	membrane-bound metal-dependent
YPD4_RS08950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPD4_RS08955	COG1653	transport
YPD4_RS08960	COG3842	ATPase activity
YPD4_RS08965	COG0395	ABC-type sugar transport system, permease component
YPD4_RS08970	COG1175	transmembrane transport
YPD4_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS08990	COG1917	Cupin 2, conserved barrel domain protein
YPD4_RS08995	COG3328	transposase activity
YPD4_RS09040	COG1132	(ABC) transporter
YPD4_RS09050	COG2207	Transcriptional regulator
YPD4_RS09110	COG1496	oxidoreductase activity
YPD4_RS09115	COG2226	methyltransferase
YPD4_RS09125	COG3447	MASE1 domain protein
YPD4_RS09125	COG5001	Diguanylate cyclase
YPD4_RS09125	COG5002	protein histidine kinase activity
YPD4_RS09145	COG3716	PTS system mannose fructose sorbose family IID component
YPD4_RS09150	COG3715	PTS system
YPD4_RS09155	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_RS09155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_RS09160	COG1253	flavin adenine dinucleotide binding
YPD4_RS09165	COG1846	Transcriptional regulator
YPD4_RS09180	COG1012	belongs to the aldehyde dehydrogenase family
YPD4_RS09185	COG3384	dioxygenase
YPD4_RS09195	COG3971	2-oxopent-4-enoate hydratase activity
YPD4_RS09210	COG2368	4-hydroxyphenylacetate
YPD4_RS09215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
YPD4_RS09220	COG1760	l-serine dehydratase
YPD4_RS09245	COG0513	Belongs to the DEAD box helicase family
YPD4_RS09250	COG3141	response to X-ray
YPD4_RS09265	COG1770	oligopeptidase
YPD4_RS09280	COG1528	Iron-storage protein
YPD4_RS09285	COG2372	response to copper ion
YPD4_RS09315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD4_RS09320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
YPD4_RS09345	COG3418	PFAM FlgN family protein
YPD4_RS09350	COG2747	anti-sigma28 factor FlgM
YPD4_RS09360	COG1815	bacterial-type flagellum-dependent cell motility
YPD4_RS09365	COG1558	bacterial-type flagellum-dependent cell motility
YPD4_RS09405	COG1256	bacterial-type flagellum assembly
YPD4_RS09415	COG2390	Transcriptional regulator
YPD4_RS09420	COG3347	Dehydrogenase
YPD4_RS09420	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS09425	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS09435	COG1129	ABC transporter
YPD4_RS09440	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS09445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_RS09465	COG1987	bacterial-type flagellum assembly
YPD4_RS09490	COG1580	Controls the rotational direction of flagella during chemotaxis
YPD4_RS09525	COG1677	Flagellar hook-basal body complex protein FliE
YPD4_RS09540	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
YPD4_RS09545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
YPD4_RS09550	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
YPD4_RS09585	COG1191	sigma factor activity
YPD4_RS09600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS09605	COG0765	amino acid transport
YPD4_RS09610	COG1126	abc transporter atp-binding protein
YPD4_RS09625	COG0506	proline dehydrogenase activity
YPD4_RS09625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD4_RS09625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
YPD4_RS09640	COG0672	)-iron permease
YPD4_RS09645	COG2822	iron ion transport
YPD4_RS09665	COG1113	amino acid transport
YPD4_RS09690	COG3136	membrane protein required for alginate biosynthesis
YPD4_RS09700	COG2197	response regulator
YPD4_RS09840	COG2188	Transcriptional regulator
YPD4_RS09850	COG0673	inositol 2-dehydrogenase activity
YPD4_RS09860	COG1175	transmembrane transport
YPD4_RS09865	COG0395	ABC-type sugar transport system, permease component
YPD4_RS09870	COG3842	ATPase activity
YPD4_RS09945	COG4771	TonB-dependent receptor
YPD4_RS09950	COG1021	2,3-dihydroxybenzoate-AMP ligase
YPD4_RS09970	COG3433	isochorismatase activity
YPD4_RS09970	COG2226	methyltransferase
YPD4_RS09970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
YPD4_RS09985	COG1132	(ABC) transporter
YPD4_RS09990	COG2814	Major facilitator Superfamily
YPD4_RS09995	COG1169	isochorismate synthase
YPD4_RS10000	COG0582	viral genome integration into host DNA
YPD4_RS10010	COG3121	Chaperone
YPD4_RS10020	COG3188	usher protein
YPD4_RS10035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS10035	COG2205	protein histidine kinase activity
YPD4_RS10045	COG0427	acetyl-CoA hydrolase
YPD4_RS10050	COG2030	dehydratase
YPD4_RS10075	COG2814	Major facilitator Superfamily
YPD4_RS10090	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD4_RS10095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPD4_RS10105	COG1349	DNA-binding transcription factor activity
YPD4_RS10115	COG2066	Belongs to the glutaminase family
YPD4_RS10125	COG0672	)-iron permease
YPD4_RS10140	COG0577	efflux transmembrane transporter activity
YPD4_RS10140	COG1136	(ABC) transporter
YPD4_RS10150	COG1136	(ABC) transporter
YPD4_RS10150	COG0577	efflux transmembrane transporter activity
YPD4_RS10170	COG0006	proline dipeptidase activity
YPD4_RS10175	COG0457	Tetratricopeptide repeat
YPD4_RS10180	COG1649	PFAM Uncharacterised BCR, COG1649
YPD4_RS10180	COG0726	polysaccharide deacetylase
YPD4_RS10185	COG1215	transferase activity, transferring glycosyl groups
YPD4_RS10190	COG3658	cytochrome
YPD4_RS10205	COG1702	phosphate starvation-inducible protein PhoH
YPD4_RS10210	COG0387	Pfam Sodium calcium exchanger
YPD4_RS10215	COG3850	Histidine kinase
YPD4_RS10220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
YPD4_RS10285	COG0402	S-adenosylhomocysteine deaminase activity
YPD4_RS10300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPD4_RS10305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
YPD4_RS10310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_RS10355	COG3328	transposase activity
YPD4_RS10380	COG0500	methyltransferase
YPD4_RS10420	COG5002	protein histidine kinase activity
YPD4_RS10475	COG0012	GTP binding
YPD4_RS10495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
YPD4_RS10525	COG2890	protein-(glutamine-N5) methyltransferase activity
YPD4_RS10570	COG3833	ABC-type maltose transport systems, permease component
YPD4_RS10575	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD4_RS10590	COG3842	ATPase activity
YPD4_RS10595	COG0584	glycerophosphoryl diester phosphodiesterase
YPD4_RS10600	COG1940	carbohydrate kinase activity
YPD4_RS10615	COG3381	protein complex oligomerization
YPD4_RS10630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD4_RS10635	COG0673	inositol 2-dehydrogenase activity
YPD4_RS10640	COG0728	peptidoglycan biosynthetic process
YPD4_RS10660	COG3102	Protein conserved in bacteria
YPD4_RS10680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
YPD4_RS10685	COG1801	Protein of unknown function DUF72
YPD4_RS10695	COG0494	nUDIX hydrolase
YPD4_RS10720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
YPD4_RS10730	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
YPD4_RS10740	COG1560	Kdo2-lipid A biosynthetic process
YPD4_RS10745	COG0469	pyruvate kinase activity
YPD4_RS10750	COG1737	Transcriptional regulator
YPD4_RS10755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
YPD4_RS10765	COG0800	Aldolase
YPD4_RS10780	COG0251	oxidation-reduction process
YPD4_RS10785	COG1199	ATP-dependent helicase activity
YPD4_RS10795	COG3065	identical protein binding
YPD4_RS10800	COG0318	PFAM AMP-dependent synthetase and ligase
YPD4_RS10805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
YPD4_RS10810	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
YPD4_RS10815	COG2894	cell division
YPD4_RS10830	COG2951	lytic endotransglycosylase activity
YPD4_RS10835	COG0179	Fumarylacetoacetate (FAA) hydrolase
YPD4_RS10845	COG0582	viral genome integration into host DNA
YPD4_RS10945	COG3328	transposase activity
YPD4_RS11120	COG3328	transposase activity
YPD4_RS11130	COG1104	cysteine desulfurase activity
YPD4_RS11160	COG2719	SpoVR family
YPD4_RS11170	COG2814	Major facilitator Superfamily
YPD4_RS11180	COG0583	DNA-binding transcription factor activity
YPD4_RS11195	COG2766	serine protein kinase
YPD4_RS11200	COG3713	MltA-interacting MipA family protein
YPD4_RS11220	COG3139	Protein of unknown function (DUF1315)
YPD4_RS11225	COG1335	isochorismatase
YPD4_RS11230	COG0252	asparaginase activity
YPD4_RS11240	COG0778	Nitroreductase
YPD4_RS11245	COG0709	Synthesizes selenophosphate from selenide and ATP
YPD4_RS11250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
YPD4_RS11260	COG0494	nUDIX hydrolase
YPD4_RS11265	COG0708	Exodeoxyribonuclease III
YPD4_RS11270	COG0583	DNA-binding transcription factor activity
YPD4_RS11280	COG3328	transposase activity
YPD4_RS11285	COG0788	formyltetrahydrofolate deformylase activity
YPD4_RS11295	COG0745	RESPONSE REGULATOR receiver
YPD4_RS11330	COG2095	MarC family integral membrane protein
YPD4_RS11340	COG0601	transmembrane transport
YPD4_RS11345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_RS11350	COG0444	Belongs to the ABC transporter superfamily
YPD4_RS11355	COG4608	Belongs to the ABC transporter superfamily
YPD4_RS11395	COG2350	Protein conserved in bacteria
YPD4_RS11400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
YPD4_RS11405	COG3328	transposase activity
YPD4_RS11445	COG3047	cAMP biosynthetic process
YPD4_RS11465	COG0135	phosphoribosylanthranilate isomerase activity
YPD4_RS11465	COG0134	indole-3-glycerol-phosphate synthase activity
YPD4_RS11475	COG0512	Glutamine amidotransferase of anthranilate synthase
YPD4_RS11500	COG0009	L-threonylcarbamoyladenylate synthase
YPD4_RS11505	COG1187	pseudouridine synthase activity
YPD4_RS11515	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS11520	COG0616	signal peptide processing
YPD4_RS11540	COG0583	DNA-binding transcription factor activity
YPD4_RS11550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
YPD4_RS11560	COG0671	phosphoesterase, PA-phosphatase related
YPD4_RS11565	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
YPD4_RS11585	COG0023	Translation Initiation Factor
YPD4_RS11605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
YPD4_RS11610	COG2879	small protein
YPD4_RS11615	COG1966	Carbon starvation protein
YPD4_RS11625	COG2271	Major facilitator Superfamily
YPD4_RS11630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_RS11635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
YPD4_RS11645	COG4659	FMN binding
YPD4_RS11650	COG4658	electron transport chain
YPD4_RS11655	COG3708	Transcriptional regulator
YPD4_RS11655	COG2207	Transcriptional regulator
YPD4_RS11685	COG1132	(ABC) transporter
YPD4_RS11695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_RS11700	COG2274	protein secretion by the type I secretion system
YPD4_RS11715	COG1879	ABC-type sugar transport system periplasmic component
YPD4_RS11720	COG1129	ABC transporter
YPD4_RS11725	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS11735	COG0673	inositol 2-dehydrogenase activity
YPD4_RS11750	COG5339	Protein conserved in bacteria
YPD4_RS11760	COG0114	fumarate hydratase activity
YPD4_RS11775	COG0583	DNA-binding transcription factor activity
YPD4_RS11780	COG1940	carbohydrate kinase activity
YPD4_RS11785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
YPD4_RS11790	COG0038	chloride channel
YPD4_RS11800	COG1609	Transcriptional regulator
YPD4_RS11820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD4_RS11825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
YPD4_RS11850	COG0028	Belongs to the TPP enzyme family
YPD4_RS11855	COG0440	acetolactate synthase activity
YPD4_RS11860	COG1011	Hydrolase
YPD4_RS11880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
YPD4_RS11885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
YPD4_RS11890	COG0589	response to stress
YPD4_RS11895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
YPD4_RS11900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
YPD4_RS11915	COG0531	amino acid
YPD4_RS11925	COG0745	RESPONSE REGULATOR receiver
YPD4_RS11930	COG2205	protein histidine kinase activity
YPD4_RS11935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
YPD4_RS11970	COG3038	cytochrome b561
YPD4_RS11985	COG3591	Belongs to the peptidase S1B family
YPD4_RS12000	COG1643	Atp-dependent helicase
YPD4_RS12010	COG2390	Transcriptional regulator
YPD4_RS12015	COG0246	Mannitol dehydrogenase
YPD4_RS12020	COG3784	Protein of unknown function (DUF1318)
YPD4_RS12030	COG2911	Protein conserved in bacteria
YPD4_RS12035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPD4_RS12040	COG3187	Heat shock protein
YPD4_RS12045	COG3042	response to heat
YPD4_RS12050	COG1285	pathogenesis
YPD4_RS12060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
YPD4_RS12060	COG0674	pyruvate-flavodoxin oxidoreductase activity
YPD4_RS12060	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD4_RS12060	COG1013	pyruvate-flavodoxin oxidoreductase activity
YPD4_RS12070	COG0657	acetylesterase activity
YPD4_RS12085	COG4166	transmembrane transport
YPD4_RS12090	COG2866	Carboxypeptidase
YPD4_RS12095	COG4948	Mandelate Racemase Muconate Lactonizing
YPD4_RS12130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
YPD4_RS12140	COG5295	Hep Hag repeat protein
YPD4_RS12150	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD4_RS12160	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
YPD4_RS12165	COG0745	RESPONSE REGULATOR receiver
YPD4_RS12175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
YPD4_RS12180	COG0840	transmembrane signaling receptor activity
YPD4_RS12185	COG0840	transmembrane signaling receptor activity
YPD4_RS12205	COG2964	Protein conserved in bacteria
YPD4_RS12215	COG0251	oxidation-reduction process
YPD4_RS12220	COG2271	Major facilitator Superfamily
YPD4_RS12225	COG0835	chemotaxis
YPD4_RS12230	COG0643	Histidine kinase
YPD4_RS12230	COG2198	Histidine kinase
YPD4_RS12265	COG1285	pathogenesis
YPD4_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS12295	COG3321	synthase
YPD4_RS12295	COG0604	alcohol dehydrogenase
YPD4_RS12305	COG1522	sequence-specific DNA binding
YPD4_RS12330	COG1733	regulation of RNA biosynthetic process
YPD4_RS12335	COG0702	epimerase
YPD4_RS12340	COG0840	transmembrane signaling receptor activity
YPD4_RS12355	COG0538	isocitrate dehydrogenase activity
YPD4_RS12360	COG1187	pseudouridine synthase activity
YPD4_RS12380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
YPD4_RS12390	COG0745	RESPONSE REGULATOR receiver
YPD4_RS12400	COG2850	peptidyl-arginine hydroxylation
YPD4_RS12415	COG1940	carbohydrate kinase activity
YPD4_RS12420	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPD4_RS12430	COG4591	ABC-type transport system involved in lipoprotein release permease component
YPD4_RS12435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
YPD4_RS12440	COG3134	Outer membrane lipoprotein
YPD4_RS12445	COG3328	transposase activity
YPD4_RS12460	COG1252	NADH dehydrogenase
YPD4_RS12470	COG1472	Belongs to the glycosyl hydrolase 3 family
YPD4_RS12485	COG5633	Lipoprotein
YPD4_RS12490	COG0537	adenosine 5'-monophosphoramidase activity
YPD4_RS12495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
YPD4_RS12505	COG1263	PTS System
YPD4_RS12505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_RS12510	COG0084	hydrolase, TatD family'
YPD4_RS12515	COG0470	DNA polymerase III
YPD4_RS12525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
YPD4_RS12530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPD4_RS12540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
YPD4_RS12570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
YPD4_RS12575	COG1399	metal-binding, possibly nucleic acid-binding protein
YPD4_RS12580	COG0424	maF-like protein
YPD4_RS12595	COG0564	pseudouridine synthase activity
YPD4_RS12600	COG1530	ribonuclease E activity
YPD4_RS12605	COG3328	transposase activity
YPD4_RS12610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
YPD4_RS12635	COG3328	transposase activity
YPD4_RS12650	COG0628	permease
YPD4_RS12680	COG3916	Acyl-homoserine-lactone synthase
YPD4_RS12685	COG2771	luxR family
YPD4_RS12690	COG0583	DNA-binding transcription factor activity
YPD4_RS12700	COG0477	Major facilitator Superfamily
YPD4_RS12710	COG0667	Aldo Keto reductase
YPD4_RS12740	COG1203	CRISPR-associated helicase, Cas3
YPD4_RS12745	COG1518	maintenance of DNA repeat elements
YPD4_RS12750	COG0668	transmembrane transport
YPD4_RS12770	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
YPD4_RS12775	COG0395	ABC-type sugar transport system, permease component
YPD4_RS12790	COG1609	Transcriptional regulator
YPD4_RS12800	COG3842	ATPase activity
YPD4_RS12810	COG3210	domain, Protein
YPD4_RS12850	COG3210	domain, Protein
YPD4_RS12855	COG2831	hemolysin activation secretion protein
YPD4_RS12860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_RS12865	COG4638	Rieske (2fe-2S)
YPD4_RS12870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
YPD4_RS12880	COG0473	3-isopropylmalate dehydrogenase activity
YPD4_RS12885	COG0583	DNA-binding transcription factor activity
YPD4_RS12890	COG1609	Transcriptional regulator
YPD4_RS12895	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS12900	COG1129	ABC transporter
YPD4_RS12905	COG1879	ABC-type sugar transport system periplasmic component
YPD4_RS12910	COG1063	alcohol dehydrogenase
YPD4_RS12930	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
YPD4_RS12960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS12965	COG0765	amino acid transport
YPD4_RS12970	COG1126	abc transporter atp-binding protein
YPD4_RS13000	COG2453	phosphatase
YPD4_RS13000	COG0671	phosphoesterase, PA-phosphatase related
YPD4_RS13005	COG2267	carboxylic ester hydrolase activity
YPD4_RS13015	COG4589	Belongs to the CDS family
YPD4_RS13020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
YPD4_RS13070	COG2501	S4 domain
YPD4_RS13090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
YPD4_RS13095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD4_RS13115	COG0581	inorganic phosphate transmembrane transporter activity
YPD4_RS13125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
YPD4_RS13140	COG2239	Acts as a magnesium transporter
YPD4_RS13145	COG0443	Heat shock 70 kDa protein
YPD4_RS13155	COG1176	ABC-type spermidine putrescine transport system, permease component I
YPD4_RS13165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
YPD4_RS13200	COG2205	protein histidine kinase activity
YPD4_RS13205	COG2205	protein histidine kinase activity
YPD4_RS13210	COG0745	RESPONSE REGULATOR receiver
YPD4_RS13215	COG3422	double-strand break repair
YPD4_RS13220	COG0826	peptidase U32
YPD4_RS13240	COG0351	phosphomethylpyrimidine kinase
YPD4_RS13255	COG3328	transposase activity
YPD4_RS13310	COG0517	IMP dehydrogenase activity
YPD4_RS13310	COG0516	GMP reductase activity
YPD4_RS13320	COG1645	bacterial-type flagellum-dependent swarming motility
YPD4_RS13335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD4_RS13340	COG2976	Protein conserved in bacteria
YPD4_RS13385	COG3468	outer membrane autotransporter barrel domain protein
YPD4_RS13390	COG3468	outer membrane autotransporter barrel domain protein
YPD4_RS13410	COG2975	iron-sulfur cluster assembly
YPD4_RS13415	COG0633	Ferredoxin
YPD4_RS13420	COG0443	Heat shock 70 kDa protein
YPD4_RS13435	COG0822	iron-sulfur transferase activity
YPD4_RS13465	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
YPD4_RS13470	COG3683	transport system, periplasmic component
YPD4_RS13475	COG3711	transcriptional antiterminator
YPD4_RS13500	COG1017	nitric oxide dioxygenase activity
YPD4_RS13500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_RS13505	COG2188	Transcriptional regulator
YPD4_RS13510	COG2188	Transcriptional regulator
YPD4_RS13515	COG0347	Belongs to the P(II) protein family
YPD4_RS13520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
YPD4_RS13520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD4_RS13525	COG2204	response regulator
YPD4_RS13530	COG3170	Tfp pilus assembly protein FimV
YPD4_RS13535	COG2205	protein histidine kinase activity
YPD4_RS13575	COG0560	Phosphoserine phosphatase
YPD4_RS13585	COG1737	Transcriptional regulator
YPD4_RS13590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_RS13610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
YPD4_RS13660	COG3086	response to oxidative stress
YPD4_RS13665	COG3026	antisigma factor binding
YPD4_RS13680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
YPD4_RS13690	COG0513	Belongs to the DEAD box helicase family
YPD4_RS13740	COG1984	allophanate hydrolase subunit 2
YPD4_RS13750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
YPD4_RS13755	COG5212	phosphodiesterase
YPD4_RS13765	COG3272	Protein of unknown function (DUF1722)
YPD4_RS13800	COG2205	protein histidine kinase activity
YPD4_RS13805	COG0745	RESPONSE REGULATOR receiver
YPD4_RS13825	COG0033	Phosphoglucomutase
YPD4_RS13830	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
YPD4_RS13850	COG2169	Transcriptional regulator
YPD4_RS13850	COG1917	Cupin 2, conserved barrel domain protein
YPD4_RS13855	COG1447	Phosphotransferase system cellobiose-specific component IIA
YPD4_RS13860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPD4_RS13865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
YPD4_RS13875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD4_RS13885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPD4_RS13900	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
YPD4_RS13905	COG4413	Urea transporter
YPD4_RS13915	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
YPD4_RS13940	COG0831	urea catabolic process
YPD4_RS13945	COG1124	(ABC) transporter
YPD4_RS13950	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
YPD4_RS13955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_RS13965	COG0747	negative chemotaxis
YPD4_RS14010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
YPD4_RS14015	COG4175	Glycine betaine
YPD4_RS14020	COG4176	ABC-type proline glycine betaine transport system permease component
YPD4_RS14025	COG2113	Glycine betaine
YPD4_RS14045	COG0582	viral genome integration into host DNA
YPD4_RS14050	COG2963	transposase activity
YPD4_RS14055	COG0582	viral genome integration into host DNA
YPD4_RS14065	COG0596	Alpha beta hydrolase
YPD4_RS14085	COG0735	belongs to the Fur family
YPD4_RS14120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
YPD4_RS14125	COG1846	Transcriptional regulator
YPD4_RS14125	COG1940	carbohydrate kinase activity
YPD4_RS14130	COG0647	UMP catabolic process
YPD4_RS14135	COG0367	asparagine synthase
YPD4_RS14175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
YPD4_RS14180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
YPD4_RS14185	COG1702	phosphate starvation-inducible protein PhoH
YPD4_RS14195	COG4535	Mg2 and Co2 transporter CorC
YPD4_RS14200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
YPD4_RS14210	COG0765	amino acid transport
YPD4_RS14220	COG1126	abc transporter atp-binding protein
YPD4_RS14225	COG2888	peptidyl-tyrosine sulfation
YPD4_RS14250	COG0799	negative regulation of ribosome biogenesis
YPD4_RS14260	COG0768	penicillin binding
YPD4_RS14265	COG0772	Belongs to the SEDS family
YPD4_RS14275	COG1686	Belongs to the peptidase S11 family
YPD4_RS14295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YPD4_RS14305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
YPD4_RS14315	COG1278	Cold shock
YPD4_RS14320	COG2197	response regulator
YPD4_RS14345	COG5265	(ABC) transporter
YPD4_RS14355	COG3718	enzyme involved in inositol metabolism
YPD4_RS14365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_RS14370	COG0673	inositol 2-dehydrogenase activity
YPD4_RS14375	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS14380	COG1129	ABC transporter
YPD4_RS14395	COG3962	Belongs to the TPP enzyme family
YPD4_RS14415	COG2373	Large extracellular alpha-helical protein
YPD4_RS14420	COG4953	penicillin-binding protein 1C
YPD4_RS14425	COG3328	transposase activity
YPD4_RS14440	COG1609	Transcriptional regulator
YPD4_RS14445	COG0280	phosphate acetyltransferase
YPD4_RS14445	COG0857	belongs to the CobB CobQ family
YPD4_RS14470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_RS14475	COG0490	domain, Protein
YPD4_RS14475	COG0471	metal ion transport
YPD4_RS14490	COG0436	Aminotransferase
YPD4_RS14500	COG0583	DNA-binding transcription factor activity
YPD4_RS14510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD4_RS14530	COG1034	ATP synthesis coupled electron transport
YPD4_RS14545	COG0839	Belongs to the complex I subunit 6 family
YPD4_RS14555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
YPD4_RS14560	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
YPD4_RS14575	COG2731	YhcH YjgK YiaL family protein
YPD4_RS14580	COG3265	gluconokinase activity
YPD4_RS14585	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS14590	COG1649	PFAM Uncharacterised BCR, COG1649
YPD4_RS14595	COG1609	Transcriptional regulator
YPD4_RS14605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
YPD4_RS14620	COG0129	dihydroxy-acid dehydratase activity
YPD4_RS14635	COG4575	ribosome binding
YPD4_RS14645	COG1169	isochorismate synthase
YPD4_RS14675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
YPD4_RS14705	COG0667	Aldo Keto reductase
YPD4_RS14710	COG0656	L-ascorbic acid biosynthetic process
YPD4_RS14730	COG1472	Belongs to the glycosyl hydrolase 3 family
YPD4_RS14745	COG3328	transposase activity
YPD4_RS14750	COG2850	peptidyl-arginine hydroxylation
YPD4_RS14800	COG3423	Transcriptional regulator
YPD4_RS14805	COG4953	penicillin-binding protein 1C
YPD4_RS14810	COG3328	transposase activity
YPD4_RS14815	COG3037	sugar-specific permease SgaT UlaA
YPD4_RS14820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
YPD4_RS14825	COG0622	Phosphoesterase
YPD4_RS14835	COG1090	epimerase
YPD4_RS14840	COG4598	ABC transporter
YPD4_RS14845	COG4160	amino acid transport
YPD4_RS14850	COG4215	(ABC) transporter
YPD4_RS14855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS14865	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
YPD4_RS14870	COG1286	toxin biosynthetic process
YPD4_RS14875	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
YPD4_RS14880	COG0285	dihydrofolate synthase activity
YPD4_RS14890	COG0586	Pfam SNARE associated Golgi protein
YPD4_RS14900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPD4_RS14920	COG0697	spore germination
YPD4_RS14935	COG1794	racemase activity, acting on amino acids and derivatives
YPD4_RS14955	COG3101	peptidyl-lysine hydroxylation
YPD4_RS14960	COG0730	response to heat
YPD4_RS14975	COG2890	protein-(glutamine-N5) methyltransferase activity
YPD4_RS14985	COG2062	phosphohistidine phosphatase, SixA
YPD4_RS15000	COG3691	Protein conserved in bacteria
YPD4_RS15015	COG3088	subunit of a heme lyase
YPD4_RS15015	COG4235	cytochrome complex assembly
YPD4_RS15020	COG4235	cytochrome complex assembly
YPD4_RS15020	COG3088	subunit of a heme lyase
YPD4_RS15025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
YPD4_RS15030	COG1138	Cytochrome C-type biogenesis protein
YPD4_RS15040	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD4_RS15045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD4_RS15050	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
YPD4_RS15070	COG1704	LemA family
YPD4_RS15080	COG2824	Alkylphosphonate utilization operon protein PhnA
YPD4_RS15170	COG3188	usher protein
YPD4_RS15175	COG3328	transposase activity
YPD4_RS15180	COG3188	usher protein
YPD4_RS15185	COG3121	Chaperone
YPD4_RS15245	COG2951	lytic endotransglycosylase activity
YPD4_RS15280	COG0243	molybdopterin cofactor binding
YPD4_RS15285	COG0437	4 iron, 4 sulfur cluster binding
YPD4_RS15290	COG3302	dmso reductase anchor subunit
YPD4_RS15295	COG3381	protein complex oligomerization
YPD4_RS15325	COG3038	cytochrome b561
YPD4_RS15330	COG0436	Aminotransferase
YPD4_RS15355	COG0667	Aldo Keto reductase
YPD4_RS15370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
YPD4_RS15425	COG3530	Putative quorum-sensing-regulated virulence factor
YPD4_RS15450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_RS15475	COG2205	protein histidine kinase activity
YPD4_RS15480	COG0745	RESPONSE REGULATOR receiver
YPD4_RS15485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_RS15500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
YPD4_RS15520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
YPD4_RS15530	COG5002	protein histidine kinase activity
YPD4_RS15530	COG3850	Histidine kinase
YPD4_RS15535	COG0745	RESPONSE REGULATOR receiver
YPD4_RS15550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
YPD4_RS15555	COG4208	sulfate ABC transporter
YPD4_RS15560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
YPD4_RS15565	COG4150	thiosulfate binding
YPD4_RS15585	COG2731	YhcH YjgK YiaL family protein
YPD4_RS15595	COG4886	Leucine-rich repeat (LRR) protein
YPD4_RS15605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
YPD4_RS15610	COG2837	iron assimilation
YPD4_RS15620	COG3111	PFAM Bacterial OB fold (BOF) protein
YPD4_RS15665	COG3005	denitrification pathway
YPD4_RS15670	COG3043	anaerobic respiration
YPD4_RS15680	COG3062	negative regulation of establishment of protein localization
YPD4_RS15685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_RS15685	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
YPD4_RS15690	COG2197	response regulator
YPD4_RS15700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_RS15710	COG1988	membrane-bound metal-dependent
YPD4_RS15715	COG0641	radical SAM
YPD4_RS15720	COG3119	arylsulfatase activity
YPD4_RS15725	COG3842	ATPase activity
YPD4_RS15730	COG1175	transmembrane transport
YPD4_RS15745	COG1393	Belongs to the ArsC family
YPD4_RS15755	COG1876	peptidase activity
YPD4_RS15775	COG2321	neutral zinc metallopeptidase
YPD4_RS15795	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
YPD4_RS15805	COG2716	regulation of RNA biosynthetic process
YPD4_RS15810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
YPD4_RS15830	COG0628	permease
YPD4_RS15835	COG4783	chaperone-mediated protein folding
YPD4_RS15840	COG1393	Belongs to the ArsC family
YPD4_RS15865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YPD4_RS15875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
YPD4_RS15880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
YPD4_RS15890	COG4181	ATPase activity
YPD4_RS15895	COG2755	lipolytic protein G-D-S-L family
YPD4_RS15900	COG0300	oxidoreductase activity
YPD4_RS15905	COG3118	belongs to the thioredoxin family
YPD4_RS15910	COG0330	HflC and HflK could
YPD4_RS15915	COG1585	Membrane protein implicated in regulation of membrane protease activity
YPD4_RS15920	COG0789	Transcriptional regulator
YPD4_RS15925	COG2217	Heavy metal translocating P-type atpase
YPD4_RS15930	COG3735	TraB family
YPD4_RS15935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
YPD4_RS15950	COG0737	Belongs to the 5'-nucleotidase family
YPD4_RS15955	COG0737	Belongs to the 5'-nucleotidase family
YPD4_RS15960	COG0737	Belongs to the 5'-nucleotidase family
YPD4_RS15965	COG2223	nitrite transmembrane transporter activity
YPD4_RS15970	COG4651	solute:proton antiporter activity
YPD4_RS15970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
YPD4_RS15975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_RS15980	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPD4_RS16000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_RS16040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
YPD4_RS16065	COG0543	2 iron, 2 sulfur cluster binding
YPD4_RS16065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
YPD4_RS16095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
YPD4_RS16120	COG3264	Mechanosensitive ion channel
YPD4_RS16120	COG1196	nuclear chromosome segregation
YPD4_RS16125	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
YPD4_RS16130	COG1309	transcriptional regulator
YPD4_RS16135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
YPD4_RS16150	COG0257	Belongs to the bacterial ribosomal protein bL36 family
YPD4_RS16170	COG3695	enzyme binding
YPD4_RS16175	COG3126	Type III secretion system lipoprotein chaperone (YscW)
YPD4_RS16180	COG1946	Acyl-CoA thioesterase
YPD4_RS16185	COG0004	ammonium transporteR
YPD4_RS16190	COG0347	Belongs to the P(II) protein family
YPD4_RS16195	COG1132	(ABC) transporter
YPD4_RS16200	COG1132	(ABC) transporter
YPD4_RS16205	COG1522	sequence-specific DNA binding
YPD4_RS16220	COG4533	DNA binding
YPD4_RS16230	COG0824	Thioesterase
YPD4_RS16235	COG1555	photosystem II stabilization
YPD4_RS16240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPD4_RS16245	COG0776	regulation of translation
YPD4_RS16275	COG0271	Belongs to the BolA IbaG family
YPD4_RS16280	COG3056	Lipoprotein
YPD4_RS16285	COG2223	nitrite transmembrane transporter activity
YPD4_RS16295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
YPD4_RS16300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
YPD4_RS16305	COG1845	cytochrome c oxidase, subunit III
YPD4_RS16310	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
YPD4_RS16320	COG2814	Major facilitator Superfamily
YPD4_RS16330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
YPD4_RS16335	COG0693	protein deglycase activity
YPD4_RS16355	COG0142	geranyltranstransferase activity
YPD4_RS16375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
YPD4_RS16380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
YPD4_RS16395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPD4_RS16395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
YPD4_RS16425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPD4_RS16430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
YPD4_RS16435	COG1862	Preprotein translocase
YPD4_RS16455	COG0450	alkyl hydroperoxide reductase
YPD4_RS16480	COG0366	Alpha amylase catalytic
YPD4_RS16500	COG5002	protein histidine kinase activity
YPD4_RS16505	COG0745	RESPONSE REGULATOR receiver
YPD4_RS16515	COG0420	3'-5' exonuclease activity
YPD4_RS16520	COG0419	ATPase involved in DNA repair
YPD4_RS16525	COG1940	carbohydrate kinase activity
YPD4_RS16560	COG2226	methyltransferase
YPD4_RS16620	COG2195	Cleaves the N-terminal amino acid of tripeptides
YPD4_RS16640	COG1477	protein flavinylation
YPD4_RS16660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
YPD4_RS16665	COG1805	sodium ion transport
YPD4_RS16675	COG3034	peptidoglycan biosynthetic process
YPD4_RS16680	COG0121	glutamine amidotransferase
YPD4_RS16690	COG1960	acyl-CoA dehydrogenase activity
YPD4_RS16700	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
YPD4_RS16720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPD4_RS16735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
YPD4_RS16745	COG0765	amino acid transport
YPD4_RS16785	COG2814	Major facilitator Superfamily
YPD4_RS16790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
YPD4_RS16800	COG1846	Transcriptional regulator
YPD4_RS16805	COG1566	PFAM secretion protein HlyD family protein
YPD4_RS16815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
YPD4_RS16825	COG3148	PFAM DTW domain containing protein
YPD4_RS16830	COG0045	succinate-CoA ligase (ADP-forming) activity
YPD4_RS16830	COG1042	CoA-binding domain protein
YPD4_RS16830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
YPD4_RS16835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
YPD4_RS16840	COG5544	Lipoprotein
YPD4_RS16885	COG0564	pseudouridine synthase activity
YPD4_RS16890	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
YPD4_RS16895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
YPD4_RS16910	COG1605	Chorismate mutase
YPD4_RS16910	COG0077	Prephenate dehydratase
YPD4_RS16915	COG1605	Chorismate mutase
YPD4_RS16915	COG0287	Prephenate dehydrogenase
YPD4_RS16925	COG3279	Response regulator of the LytR AlgR family
YPD4_RS16930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_RS16935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_RS16940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
YPD4_RS16945	COG3137	Salt-induced outer membrane protein
YPD4_RS16980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
YPD4_RS16985	COG4137	Cytochrome C assembly protein
YPD4_RS16990	COG4536	flavin adenine dinucleotide binding
YPD4_RS17010	COG2918	glutathione biosynthetic process
YPD4_RS17015	COG1238	metal cluster binding
YPD4_RS17020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_RS17040	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
YPD4_RS17080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
YPD4_RS17085	COG3958	Transketolase
YPD4_RS17090	COG3959	Transketolase, thiamine diphosphate binding domain
YPD4_RS17095	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS17100	COG1129	ABC transporter
YPD4_RS17110	COG1879	ABC-type sugar transport system periplasmic component
YPD4_RS17120	COG3783	Cytochrome b(562)
YPD4_RS17125	COG3038	cytochrome b561
YPD4_RS17130	COG3381	protein complex oligomerization
YPD4_RS17135	COG3302	dmso reductase anchor subunit
YPD4_RS17140	COG0437	4 iron, 4 sulfur cluster binding
YPD4_RS17145	COG0243	molybdopterin cofactor binding
YPD4_RS17150	COG0235	Class ii aldolase
YPD4_RS17155	COG1349	DNA-binding transcription factor activity
YPD4_RS17170	COG1129	ABC transporter
YPD4_RS17175	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS17180	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS17185	COG3623	hexulose-6-phosphate isomerase
YPD4_RS17190	COG1070	Carbohydrate kinase
YPD4_RS17195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
YPD4_RS17195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
YPD4_RS17205	COG0024	Methionine aminopeptidase
YPD4_RS17225	COG4771	TonB-dependent receptor
YPD4_RS17240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS17260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
YPD4_RS17275	COG2376	Dihydroxyacetone kinase
YPD4_RS17280	COG1028	Short-chain dehydrogenase reductase Sdr
YPD4_RS17285	COG1063	alcohol dehydrogenase
YPD4_RS17290	COG0698	ribose 5-phosphate isomerase
YPD4_RS17305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YPD4_RS17310	COG4942	peptidase
YPD4_RS17310	COG1388	LysM domain
YPD4_RS17350	COG0529	Catalyzes the synthesis of activated sulfate
YPD4_RS17400	COG0720	synthase
YPD4_RS17405	COG0602	queuosine metabolic process
YPD4_RS17425	COG3956	TIGRFAM MazG family protein
YPD4_RS17435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
YPD4_RS17440	COG3437	response regulator, receiver
YPD4_RS17440	COG3850	Histidine kinase
YPD4_RS17440	COG2205	protein histidine kinase activity
YPD4_RS17440	COG4999	Histidine kinase
YPD4_RS17465	COG2860	membrane
YPD4_RS17485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
YPD4_RS17490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
YPD4_RS17500	COG1120	ATPase activity
YPD4_RS17505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
YPD4_RS17510	COG1643	Atp-dependent helicase
YPD4_RS17515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
YPD4_RS17530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
YPD4_RS17535	COG0617	tRNA 3'-terminal CCA addition
YPD4_RS17540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
YPD4_RS17565	COG0842	Transport permease protein
YPD4_RS17570	COG1131	(ABC) transporter
YPD4_RS17575	COG0288	reversible hydration of carbon dioxide
YPD4_RS17580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
YPD4_RS17585	COG2132	Multicopper oxidase
YPD4_RS17605	COG0697	spore germination
YPD4_RS17615	COG1049	propionate catabolic process, 2-methylcitrate cycle
YPD4_RS17630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD4_RS17635	COG0508	dehydrogenase complex catalyzes the overall conversion of
YPD4_RS17640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
YPD4_RS17645	COG2186	Transcriptional regulator
YPD4_RS17650	COG1113	amino acid transport
YPD4_RS17655	COG3725	Membrane protein required for beta-lactamase induction
YPD4_RS17660	COG3023	N-Acetylmuramoyl-L-alanine amidase
YPD4_RS17670	COG4969	Belongs to the N-Me-Phe pilin family
YPD4_RS17675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
YPD4_RS17680	COG1459	type II secretion system
YPD4_RS17735	COG0582	viral genome integration into host DNA
YPD4_RS17745	COG0795	lipopolysaccharide-transporting ATPase activity
YPD4_RS17760	COG2927	DNA polymerase III (CHI subunit)
YPD4_RS17765	COG0525	valine-tRNA ligase activity
YPD4_RS17775	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
YPD4_RS17785	COG2731	YhcH YjgK YiaL family protein
YPD4_RS17795	COG0601	transmembrane transport
YPD4_RS17800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_RS17805	COG0444	Belongs to the ABC transporter superfamily
YPD4_RS17810	COG4608	Belongs to the ABC transporter superfamily
YPD4_RS17825	COG2188	Transcriptional regulator
YPD4_RS17830	COG3624	Phosphonate C-P lyase system protein PhnG
YPD4_RS17835	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
YPD4_RS17840	COG3626	phosphonate metabolism
YPD4_RS17845	COG3627	carbon phosphorus lyase activity
YPD4_RS17850	COG4107	phosphonate C-P lyase system protein PhnK
YPD4_RS17855	COG4778	phosphonate C-P lyase system protein PhnL
YPD4_RS17860	COG3454	Phosphonate metabolism
YPD4_RS17865	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
YPD4_RS17870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
YPD4_RS17875	COG0702	epimerase
YPD4_RS17890	COG3842	ATPase activity
YPD4_RS17895	COG0395	ABC-type sugar transport system, permease component
YPD4_RS17900	COG1175	transmembrane transport
YPD4_RS17905	COG1653	transport
YPD4_RS17925	COG3153	acetyltransferase
YPD4_RS17930	COG3154	lipid carrier protein
YPD4_RS17940	COG0826	peptidase U32
YPD4_RS17945	COG0826	peptidase U32
YPD4_RS17955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
YPD4_RS17965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
YPD4_RS17985	COG0513	Belongs to the DEAD box helicase family
YPD4_RS18000	COG2801	Transposase and inactivated derivatives
YPD4_RS18075	COG3501	Rhs element vgr protein
YPD4_RS18120	COG3501	Rhs element vgr protein
YPD4_RS18130	COG3209	COG3209 Rhs family protein
YPD4_RS18145	COG0673	inositol 2-dehydrogenase activity
YPD4_RS18150	COG1917	Cupin 2, conserved barrel domain protein
YPD4_RS18150	COG2207	Transcriptional regulator
YPD4_RS18155	COG1869	D-ribose catabolic process
YPD4_RS18160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_RS18165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
YPD4_RS18170	COG0431	NADPH-dependent FMN reductase
YPD4_RS18175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
YPD4_RS18185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
YPD4_RS18195	COG3077	Addiction module antitoxin, RelB DinJ family
YPD4_RS18200	COG2252	PERMEase
YPD4_RS18205	COG0025	NhaP-type Na H and K H
YPD4_RS18215	COG1560	Kdo2-lipid A biosynthetic process
YPD4_RS18225	COG1129	ABC transporter
YPD4_RS18230	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS18240	COG1069	ribulokinase activity
YPD4_RS18250	COG0625	glutathione transferase activity
YPD4_RS18275	COG1278	Cold shock
YPD4_RS18280	COG1278	Cold shock
YPD4_RS18290	COG3133	Outer membrane lipoprotein
YPD4_RS18295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
YPD4_RS18305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
YPD4_RS18325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
YPD4_RS18330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
YPD4_RS18340	COG4145	pantothenate transmembrane transporter activity
YPD4_RS18345	COG3924	membrane
YPD4_RS18350	COG0439	Biotin carboxylase
YPD4_RS18355	COG0511	ligase activity, forming carbon-carbon bonds
YPD4_RS18370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
YPD4_RS18375	COG0604	alcohol dehydrogenase
YPD4_RS18380	COG2199	diguanylate cyclase activity
YPD4_RS18380	COG2200	EAL domain
YPD4_RS18385	COG1077	Cell shape determining protein MreB Mrl
YPD4_RS18390	COG1792	Involved in formation and maintenance of cell shape
YPD4_RS18395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
YPD4_RS18400	COG0424	maF-like protein
YPD4_RS18405	COG1530	ribonuclease E activity
YPD4_RS18410	COG3164	Protein of unknown function
YPD4_RS18415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
YPD4_RS18420	COG0312	modulator of DNA gyrase
YPD4_RS18480	COG0583	DNA-binding transcription factor activity
YPD4_RS18500	COG1012	belongs to the aldehyde dehydrogenase family
YPD4_RS18515	COG2732	(Barnase) inhibitor
YPD4_RS18525	COG0312	modulator of DNA gyrase
YPD4_RS18535	COG3783	Cytochrome b(562)
YPD4_RS18540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YPD4_RS18545	COG0366	Alpha amylase catalytic
YPD4_RS18550	COG1263	PTS System
YPD4_RS18550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
YPD4_RS18555	COG1609	Transcriptional regulator
YPD4_RS18580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
YPD4_RS18600	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
YPD4_RS18605	COG1137	ATPase activity
YPD4_RS18610	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
YPD4_RS18615	COG3117	lipopolysaccharide transmembrane transporter activity
YPD4_RS18620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
YPD4_RS18625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
YPD4_RS18625	COG0517	IMP dehydrogenase activity
YPD4_RS18630	COG0530	calcium, potassium:sodium antiporter activity
YPD4_RS18635	COG1127	ABC transporter
YPD4_RS18640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
YPD4_RS18645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
YPD4_RS18650	COG2854	intermembrane phospholipid transfer
YPD4_RS18655	COG3113	response to antibiotic
YPD4_RS18660	COG5007	Belongs to the BolA IbaG family
YPD4_RS18670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD4_RS18680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YPD4_RS18685	COG3105	Protein conserved in bacteria
YPD4_RS18690	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
YPD4_RS18710	COG0625	glutathione transferase activity
YPD4_RS18715	COG2969	positive regulation of protein catabolic process
YPD4_RS18725	COG0493	'glutamate synthase
YPD4_RS18730	COG0067	glutamate synthase
YPD4_RS18730	COG0069	glutamate synthase activity
YPD4_RS18730	COG0070	glutamate synthase
YPD4_RS18735	COG1242	4 iron, 4 sulfur cluster binding
YPD4_RS18745	COG0784	Response regulator, receiver
YPD4_RS18745	COG5002	protein histidine kinase activity
YPD4_RS18745	COG2198	Histidine kinase
YPD4_RS18755	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
YPD4_RS18765	COG2823	Periplasmic or secreted lipoprotein
YPD4_RS18785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
YPD4_RS18790	COG1741	Belongs to the pirin family
YPD4_RS18795	COG0583	DNA-binding transcription factor activity
YPD4_RS18800	COG0435	Glutathione S-transferase
YPD4_RS18820	COG1073	alpha beta
YPD4_RS18830	COG0360	Binds together with S18 to 16S ribosomal RNA
YPD4_RS18840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
YPD4_RS18870	COG0545	Peptidyl-prolyl cis-trans isomerase
YPD4_RS18890	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
YPD4_RS18900	COG1253	flavin adenine dinucleotide binding
YPD4_RS18910	COG0729	surface antigen
YPD4_RS18915	COG2911	Protein conserved in bacteria
YPD4_RS18920	COG2105	PFAM AIG2 family protein
YPD4_RS18925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
YPD4_RS18930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
YPD4_RS18935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
YPD4_RS18960	COG3423	Transcriptional regulator
YPD4_RS18970	COG0142	geranyltranstransferase activity
YPD4_RS18985	COG0697	spore germination
YPD4_RS18995	COG0642	Histidine kinase
YPD4_RS19000	COG0745	RESPONSE REGULATOR receiver
YPD4_RS19005	COG2027	D-alanyl-D-alanine carboxypeptidase
YPD4_RS19015	COG1534	Rna-binding protein
YPD4_RS19030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
YPD4_RS19040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
YPD4_RS19060	COG0195	Participates in both transcription termination and antitermination
YPD4_RS19090	COG2801	Transposase and inactivated derivatives
YPD4_RS19150	COG1175	transmembrane transport
YPD4_RS19155	COG3833	ABC-type maltose transport systems, permease component
YPD4_RS19170	COG0527	aspartate kinase activity
YPD4_RS19190	COG1414	Transcriptional regulator
YPD4_RS19195	COG1414	Transcriptional regulator
YPD4_RS19205	COG2224	Isocitrate lyase
YPD4_RS19210	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
YPD4_RS19270	COG0151	Belongs to the GarS family
YPD4_RS19290	COG1515	deoxyribonuclease V activity
YPD4_RS19330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
YPD4_RS19395	COG0250	Participates in transcription elongation, termination and antitermination
YPD4_RS19455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
YPD4_RS19485	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
YPD4_RS19490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
YPD4_RS19495	COG1739	Uncharacterized protein family UPF0029
YPD4_RS19505	COG1739	Uncharacterized protein family UPF0029
YPD4_RS19530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
YPD4_RS19565	COG0805	protein transport
YPD4_RS19575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
YPD4_RS19595	COG1322	Protein conserved in bacteria
YPD4_RS19600	COG0586	Pfam SNARE associated Golgi protein
YPD4_RS19605	COG1966	Carbon starvation protein
YPD4_RS19620	COG0412	Dienelactone hydrolase
YPD4_RS19630	COG0583	DNA-binding transcription factor activity
YPD4_RS19635	COG0697	spore germination
YPD4_RS19640	COG0679	Auxin Efflux Carrier
YPD4_RS19645	COG0584	glycerophosphoryl diester phosphodiesterase
YPD4_RS19705	COG0410	ABC transporter
YPD4_RS19715	COG4177	L-phenylalanine transmembrane transporter activity
YPD4_RS19725	COG0683	leucine binding
YPD4_RS19750	COG2177	Part of the ABC transporter FtsEX involved in
YPD4_RS19755	COG2884	Cell division ATP-binding protein ftsE
YPD4_RS19760	COG0552	protein localization to endoplasmic reticulum
YPD4_RS19760	COG0552	protein localization to endoplasmic reticulum
YPD4_RS19770	COG0742	ribosomal rna small subunit methyltransferase
YPD4_RS19775	COG3776	membrane
YPD4_RS19790	COG3714	YhhN family
YPD4_RS19805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
YPD4_RS19815	COG0247	lactate metabolic process
YPD4_RS19825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPD4_RS19835	COG0584	glycerophosphoryl diester phosphodiesterase
YPD4_RS19845	COG0561	phosphatase activity
YPD4_RS19850	COG2267	carboxylic ester hydrolase activity
YPD4_RS19860	COG1280	lysine exporter protein (LysE YggA)
YPD4_RS19865	COG0514	ATP-dependent DNA helicase (RecQ)
YPD4_RS19870	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
YPD4_RS19875	COG2050	protein possibly involved in aromatic compounds catabolism
YPD4_RS19890	COG5564	TIM-barrel signal transduction protein
YPD4_RS19905	COG0210	DNA helicase
YPD4_RS19910	COG1011	Hydrolase
YPD4_RS19915	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
YPD4_RS19920	COG3159	Protein conserved in bacteria
YPD4_RS19940	COG3072	Adenylate cyclase
YPD4_RS19955	COG1587	Uroporphyrinogen-III synthase
YPD4_RS19960	COG2959	enzyme of heme biosynthesis
YPD4_RS19965	COG3071	HemY protein
YPD4_RS19995	COG1113	amino acid transport
YPD4_RS20015	COG2244	polysaccharide biosynthetic process
YPD4_RS20020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
YPD4_RS20025	COG0456	acetyltransferase
YPD4_RS20030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
YPD4_RS20035	COG1088	dTDP-glucose 4,6-dehydratase activity
YPD4_RS20040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
YPD4_RS20045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
YPD4_RS20050	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
YPD4_RS20055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YPD4_RS20060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
YPD4_RS20065	COG3118	belongs to the thioredoxin family
YPD4_RS20095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
YPD4_RS20105	COG3328	transposase activity
YPD4_RS20120	COG3121	Chaperone
YPD4_RS20135	COG3121	Chaperone
YPD4_RS20175	COG0583	DNA-binding transcription factor activity
YPD4_RS20220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
YPD4_RS20225	COG3978	acetolactate synthase activity
YPD4_RS20240	COG3085	chromosome segregation
YPD4_RS20250	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS20255	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS20260	COG1129	ABC transporter
YPD4_RS20265	COG1879	ABC-type sugar transport system periplasmic component
YPD4_RS20345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
YPD4_RS20345	COG0678	peroxiredoxin activity
YPD4_RS20350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD4_RS20375	COG1629	transport
YPD4_RS20395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
YPD4_RS20415	COG2801	Transposase and inactivated derivatives
YPD4_RS20435	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
YPD4_RS20440	COG0058	SHG alpha-glucan phosphorylase activity
YPD4_RS20465	COG3275	phosphorelay sensor kinase activity
YPD4_RS20495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
YPD4_RS20500	COG2095	MarC family integral membrane protein
YPD4_RS20520	COG3265	gluconokinase activity
YPD4_RS20525	COG2610	gluconate transmembrane transporter activity
YPD4_RS20530	COG1609	Transcriptional regulator
YPD4_RS20535	COG1741	Belongs to the pirin family
YPD4_RS20555	COG0191	fructose-bisphosphate aldolase activity
YPD4_RS20570	COG1172	Belongs to the binding-protein-dependent transport system permease family
YPD4_RS20585	COG2081	HI0933 family
YPD4_RS20590	COG0306	phosphate transporter
YPD4_RS20610	COG0589	response to stress
YPD4_RS20630	COG0339	signal peptide processing
YPD4_RS20635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
YPD4_RS20640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
YPD4_RS20645	COG3835	regulator
YPD4_RS20650	COG2610	gluconate transmembrane transporter activity
YPD4_RS20655	COG1929	Belongs to the glycerate kinase type-1 family
YPD4_RS20680	COG1295	ribonuclease BN
YPD4_RS20685	COG2134	cdp-diacylglycerol pyrophosphatase
YPD4_RS20690	COG2982	Protein involved in outer membrane biogenesis
YPD4_RS20695	COG2200	EAL domain
YPD4_RS20700	COG1942	4-Oxalocrotonate Tautomerase
YPD4_RS20705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
YPD4_RS20710	COG0612	Peptidase, M16
YPD4_RS20730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
YPD4_RS20735	COG2199	diguanylate cyclase activity
YPD4_RS20735	COG2200	EAL domain
YPD4_RS20740	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
YPD4_RS20745	COG4608	Belongs to the ABC transporter superfamily
YPD4_RS20750	COG0444	Belongs to the ABC transporter superfamily
YPD4_RS20755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
YPD4_RS20760	COG0601	transmembrane transport
YPD4_RS20765	COG0747	negative chemotaxis
YPD4_RS20775	COG2831	hemolysin activation secretion protein
YPD4_RS20790	COG2271	Major facilitator Superfamily
YPD4_RS20810	COG3851	Histidine kinase
YPD4_RS20815	COG2197	response regulator
YPD4_RS20820	COG2194	sulfuric ester hydrolase activity
YPD4_RS20835	COG2986	histidine ammonia-lyase
YPD4_RS20865	COG4607	ABC-type enterochelin transport system periplasmic component
YPD4_RS20875	COG4605	iron ion homeostasis
YPD4_RS20880	COG4604	ABC transporter, ATP-binding protein
YPD4_RS20920	COG0582	viral genome integration into host DNA
YPD4_RS20925	COG1609	Transcriptional regulator
YPD4_RS20925	COG2207	Transcriptional regulator
YPD4_RS20930	COG4214	carbohydrate transport
YPD4_RS20940	COG4213	ABC transporter substrate-binding protein
YPD4_RS20950	COG1070	Carbohydrate kinase
YPD4_RS20960	COG3121	Chaperone
YPD4_RS20980	COG3274	enterobacterial common antigen metabolic process
YPD4_RS20995	COG2801	Transposase and inactivated derivatives
YPD4_RS21030	COG3276	selenocysteine insertion sequence binding
YPD4_RS21045	COG2864	formate dehydrogenase
YPD4_RS21050	COG0437	4 iron, 4 sulfur cluster binding
YPD4_RS21055	COG3383	formate dehydrogenase (NAD+) activity
YPD4_RS21055	COG0243	molybdopterin cofactor binding
YPD4_RS21060	COG3383	formate dehydrogenase (NAD+) activity
YPD4_RS21060	COG0243	molybdopterin cofactor binding
YPD4_RS21070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
YPD4_RS21095	COG3722	fumarate hydratase activity
YPD4_RS21135	COG2885	chlorophyll binding
YPD4_RS21150	COG0366	Alpha amylase catalytic
YPD4_RS21160	COG3977	Valine--pyruvate aminotransferase
YPD4_RS21180	COG5645	(Lipo)protein
YPD4_RS21185	COG0823	Involved in the tonB-independent uptake of proteins
YPD4_RS21190	COG0823	Involved in the tonB-independent uptake of proteins
YPD4_RS21195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
YPD4_RS21200	COG2423	ornithine cyclodeaminase activity
YPD4_RS21210	COG2801	Transposase and inactivated derivatives
YPD4_RS21215	COG0561	phosphatase activity
YPD4_RS21220	COG0187	DNA topoisomerase II activity
YPD4_RS21235	COG0592	DNA-directed DNA polymerase activity
YPD4_RS21245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
YPD4_RS21255	COG0706	membrane insertase activity
YPD4_RS21280	COG2252	PERMEase
YPD4_RS21285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
YPD4_RS21290	COG0765	amino acid transport
YPD4_RS21295	COG0765	amino acid transport
YPD4_RS21300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
YPD4_RS21310	COG0704	Plays a role in the regulation of phosphate uptake
YPD4_RS21320	COG0581	inorganic phosphate transmembrane transporter activity
YPD4_RS21325	COG0573	inorganic phosphate transmembrane transporter activity
YPD4_RS21330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
YPD4_RS21385	COG3312	ion transport
YPD4_RS21720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
YPD4_RS21835	COG0859	PFAM glycosyl transferase family 9
YPD4_RS22115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)