locus-tag	class	description
ISU57_RS00010	COG0592	DNA-directed DNA polymerase activity
ISU57_RS00025	COG0187	DNA topoisomerase II activity
ISU57_RS00030	COG0561	phosphatase activity
ISU57_RS00040	COG2423	ornithine cyclodeaminase activity
ISU57_RS00045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU57_RS00055	COG5645	(Lipo)protein
ISU57_RS00075	COG3977	Valine--pyruvate aminotransferase
ISU57_RS00085	COG0366	Alpha amylase catalytic
ISU57_RS00100	COG2885	chlorophyll binding
ISU57_RS00110	COG2818	Glycosylase
ISU57_RS00135	COG2213	PTS system mannitol-specific
ISU57_RS00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS00145	COG3722	fumarate hydratase activity
ISU57_RS00170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU57_RS00185	COG0437	4 iron, 4 sulfur cluster binding
ISU57_RS00190	COG2864	formate dehydrogenase
ISU57_RS00205	COG3276	selenocysteine insertion sequence binding
ISU57_RS00250	COG3274	enterobacterial common antigen metabolic process
ISU57_RS00275	COG1070	Carbohydrate kinase
ISU57_RS00285	COG4213	ABC transporter substrate-binding protein
ISU57_RS00295	COG4214	carbohydrate transport
ISU57_RS00300	COG2207	Transcriptional regulator
ISU57_RS00300	COG1609	Transcriptional regulator
ISU57_RS00310	COG0582	viral genome integration into host DNA
ISU57_RS00355	COG4604	ABC transporter, ATP-binding protein
ISU57_RS00360	COG4605	iron ion homeostasis
ISU57_RS00370	COG4607	ABC-type enterochelin transport system periplasmic component
ISU57_RS00400	COG2986	histidine ammonia-lyase
ISU57_RS00415	COG2194	sulfuric ester hydrolase activity
ISU57_RS00420	COG2197	response regulator
ISU57_RS00440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU57_RS00455	COG0551	DNA topoisomerase type I activity
ISU57_RS00465	COG0758	DNA mediated transformation
ISU57_RS00495	COG3036	rescue of stalled ribosome
ISU57_RS00500	COG0789	Transcriptional regulator
ISU57_RS00515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU57_RS00530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU57_RS00535	COG0201	protein transport
ISU57_RS00545	COG1841	ribosomal large subunit assembly
ISU57_RS00585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU57_RS00590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU57_RS00600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU57_RS00605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU57_RS00615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU57_RS00625	COG0089	rRNA binding
ISU57_RS00640	COG0051	transcription antitermination factor activity, RNA binding
ISU57_RS00670	COG0049	tRNA binding
ISU57_RS00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU57_RS00695	COG2964	Protein conserved in bacteria
ISU57_RS00700	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU57_RS00710	COG1047	Peptidyl-prolyl cis-trans
ISU57_RS00715	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU57_RS00735	COG1216	Glycosyl transferase, family 2
ISU57_RS00745	COG2175	clavaminate synthase activity
ISU57_RS00750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU57_RS00760	COG4521	taurine ABC transporter
ISU57_RS00770	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU57_RS00780	COG3954	Phosphoribulokinase
ISU57_RS00790	COG1765	OsmC-like protein
ISU57_RS00800	COG1289	transmembrane transporter activity
ISU57_RS00815	COG0433	COG0433 Predicted ATPase
ISU57_RS00820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU57_RS00825	COG1486	melibiose metabolic process
ISU57_RS00845	COG0402	S-adenosylhomocysteine deaminase activity
ISU57_RS00850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU57_RS00870	COG0180	Tryptophanyl-tRNA synthetase
ISU57_RS00875	COG0546	phosphoglycolate phosphatase activity
ISU57_RS00880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU57_RS00905	COG4796	Type ii and iii secretion system protein
ISU57_RS00930	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU57_RS00935	COG0494	nUDIX hydrolase
ISU57_RS00945	COG1011	Hydrolase
ISU57_RS00950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU57_RS00975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU57_RS00980	COG2183	response to ionizing radiation
ISU57_RS00985	COG1918	ferrous iron import across plasma membrane
ISU57_RS01020	COG1640	4-alpha-glucanotransferase
ISU57_RS01025	COG0058	SHG alpha-glucan phosphorylase activity
ISU57_RS01030	COG0058	SHG alpha-glucan phosphorylase activity
ISU57_RS01050	COG1349	DNA-binding transcription factor activity
ISU57_RS01075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU57_RS01080	COG0058	SHG alpha-glucan phosphorylase activity
ISU57_RS01105	COG3275	phosphorelay sensor kinase activity
ISU57_RS01140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU57_RS01145	COG2095	MarC family integral membrane protein
ISU57_RS01165	COG3265	gluconokinase activity
ISU57_RS01170	COG2610	gluconate transmembrane transporter activity
ISU57_RS01175	COG1609	Transcriptional regulator
ISU57_RS01180	COG1741	Belongs to the pirin family
ISU57_RS01200	COG0191	fructose-bisphosphate aldolase activity
ISU57_RS01215	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS01230	COG2081	HI0933 family
ISU57_RS01235	COG0306	phosphate transporter
ISU57_RS01250	COG0589	response to stress
ISU57_RS01270	COG0339	signal peptide processing
ISU57_RS01275	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU57_RS01280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU57_RS01285	COG3835	regulator
ISU57_RS01295	COG2610	gluconate transmembrane transporter activity
ISU57_RS01300	COG1929	Belongs to the glycerate kinase type-1 family
ISU57_RS01325	COG1295	ribonuclease BN
ISU57_RS01330	COG2134	cdp-diacylglycerol pyrophosphatase
ISU57_RS01335	COG2982	Protein involved in outer membrane biogenesis
ISU57_RS01340	COG2200	EAL domain
ISU57_RS01345	COG1942	4-Oxalocrotonate Tautomerase
ISU57_RS01350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_RS01355	COG0612	Peptidase, M16
ISU57_RS01375	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU57_RS01380	COG2199	diguanylate cyclase activity
ISU57_RS01380	COG2200	EAL domain
ISU57_RS01385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU57_RS01395	COG4608	Belongs to the ABC transporter superfamily
ISU57_RS01400	COG0444	Belongs to the ABC transporter superfamily
ISU57_RS01405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_RS01410	COG0601	transmembrane transport
ISU57_RS01415	COG0747	negative chemotaxis
ISU57_RS01420	COG2831	hemolysin activation secretion protein
ISU57_RS01435	COG2271	Major facilitator Superfamily
ISU57_RS01490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU57_RS01495	COG2224	Isocitrate lyase
ISU57_RS01525	COG0527	aspartate kinase activity
ISU57_RS01540	COG3833	ABC-type maltose transport systems, permease component
ISU57_RS01545	COG1175	transmembrane transport
ISU57_RS01625	COG2885	chlorophyll binding
ISU57_RS01630	COG2199	diguanylate cyclase activity
ISU57_RS01645	COG0741	lytic transglycosylase activity
ISU57_RS01650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU57_RS01665	COG2207	Transcriptional regulator
ISU57_RS01665	COG3708	Transcriptional regulator
ISU57_RS01670	COG3045	CreA protein
ISU57_RS01675	COG0745	RESPONSE REGULATOR receiver
ISU57_RS01715	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU57_RS01730	COG1584	GPR1 FUN34 yaaH family protein
ISU57_RS01750	COG0583	DNA-binding transcription factor activity
ISU57_RS01760	COG0196	riboflavin kinase activity
ISU57_RS01775	COG1047	Peptidyl-prolyl cis-trans
ISU57_RS01800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU57_RS01805	COG1280	lysine exporter protein (LysE YggA)
ISU57_RS01810	COG2966	Psort location CytoplasmicMembrane, score
ISU57_RS01820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU57_RS01870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU57_RS01875	COG0564	pseudouridine synthase activity
ISU57_RS01960	COG3047	cAMP biosynthetic process
ISU57_RS01960	COG2885	chlorophyll binding
ISU57_RS01980	COG0417	DNA replication proofreading
ISU57_RS01985	COG0586	Pfam SNARE associated Golgi protein
ISU57_RS01990	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU57_RS01995	COG1178	ABC-type Fe3 transport system permease component
ISU57_RS02000	COG4143	(ABC) transporter
ISU57_RS02010	COG2814	Major facilitator Superfamily
ISU57_RS02025	COG0473	3-isopropylmalate dehydrogenase activity
ISU57_RS02050	COG1022	Amp-dependent synthetase and ligase
ISU57_RS02055	COG0028	Belongs to the TPP enzyme family
ISU57_RS02070	COG1609	Transcriptional regulator
ISU57_RS02095	COG3116	cell division
ISU57_RS02100	COG0768	penicillin binding
ISU57_RS02105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU57_RS02110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU57_RS02125	COG0772	Belongs to the SEDS family
ISU57_RS02145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU57_RS02150	COG0849	cell division
ISU57_RS02155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU57_RS02185	COG0494	nUDIX hydrolase
ISU57_RS02205	COG2259	Doxx family
ISU57_RS02215	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU57_RS02220	COG4575	ribosome binding
ISU57_RS02235	COG0586	Pfam SNARE associated Golgi protein
ISU57_RS02250	COG2271	Major facilitator Superfamily
ISU57_RS02265	COG2721	sulfolactate sulfo-lyase activity
ISU57_RS02285	COG0673	inositol 2-dehydrogenase activity
ISU57_RS02290	COG1451	nucleotide metabolic process
ISU57_RS02305	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU57_RS02305	COG1902	pentaerythritol trinitrate reductase activity
ISU57_RS02310	COG3247	response to pH
ISU57_RS02325	COG4245	von Willebrand factor, type A
ISU57_RS02340	COG4245	von Willebrand factor, type A
ISU57_RS02345	COG2831	hemolysin activation secretion protein
ISU57_RS02350	COG3210	domain, Protein
ISU57_RS02380	COG3210	domain, Protein
ISU57_RS02385	COG3210	domain, Protein
ISU57_RS02405	COG3842	ATPase activity
ISU57_RS02410	COG3459	Glycosyltransferase 36 associated
ISU57_RS02415	COG1609	Transcriptional regulator
ISU57_RS02420	COG2182	Extracellular solute-binding protein
ISU57_RS02430	COG0395	ABC-type sugar transport system, permease component
ISU57_RS02450	COG1289	transmembrane transporter activity
ISU57_RS02470	COG0436	Aminotransferase
ISU57_RS02490	COG0251	oxidation-reduction process
ISU57_RS02560	COG0358	DNA primase activity
ISU57_RS02565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU57_RS02580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU57_RS02595	COG4991	sh3 domain protein
ISU57_RS02600	COG3025	triphosphatase activity
ISU57_RS02615	COG0531	amino acid
ISU57_RS02635	COG3384	dioxygenase
ISU57_RS02640	COG0754	glutathionylspermidine amidase activity
ISU57_RS02650	COG1538	Outer membrane efflux protein
ISU57_RS02655	COG0494	nUDIX hydrolase
ISU57_RS02660	COG3151	Protein conserved in bacteria
ISU57_RS02665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU57_RS02670	COG3150	esterase
ISU57_RS02680	COG0583	DNA-binding transcription factor activity
ISU57_RS02685	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU57_RS02695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU57_RS02705	COG2132	Multicopper oxidase
ISU57_RS02715	COG0656	L-ascorbic acid biosynthetic process
ISU57_RS02725	COG1979	alcohol dehydrogenase
ISU57_RS02730	COG2207	Transcriptional regulator
ISU57_RS02735	COG0586	Pfam SNARE associated Golgi protein
ISU57_RS02740	COG0626	cystathionine gamma-synthase activity
ISU57_RS02745	COG0811	peptide transport
ISU57_RS02750	COG0848	biopolymer transport protein
ISU57_RS02800	COG4964	Belongs to the GSP D family
ISU57_RS02805	COG4964	Belongs to the GSP D family
ISU57_RS02840	COG4592	Periplasmic binding protein
ISU57_RS02860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU57_RS02865	COG1684	flagellar biosynthetic protein fliR
ISU57_RS02870	COG1987	bacterial-type flagellum assembly
ISU57_RS02895	COG1677	Flagellar hook-basal body complex protein FliE
ISU57_RS02935	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU57_RS02940	COG1815	bacterial-type flagellum-dependent cell motility
ISU57_RS02945	COG1558	bacterial-type flagellum-dependent cell motility
ISU57_RS02950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU57_RS02955	COG1749	Flagellar hook protein flgE
ISU57_RS02960	COG4787	bacterial-type flagellum-dependent cell motility
ISU57_RS02965	COG4786	Flagellar basal body rod
ISU57_RS02975	COG1706	bacterial-type flagellum-dependent cell motility
ISU57_RS02985	COG1256	bacterial-type flagellum assembly
ISU57_RS03005	COG3710	Transcriptional regulator
ISU57_RS03030	COG0471	metal ion transport
ISU57_RS03055	COG3501	Rhs element vgr protein
ISU57_RS03070	COG2610	gluconate transmembrane transporter activity
ISU57_RS03085	COG1132	(ABC) transporter
ISU57_RS03090	COG2375	cellular response to nickel ion
ISU57_RS03090	COG1132	(ABC) transporter
ISU57_RS03115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU57_RS03115	COG2226	methyltransferase
ISU57_RS03115	COG3433	isochorismatase activity
ISU57_RS03125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU57_RS03125	COG2226	methyltransferase
ISU57_RS03125	COG3433	isochorismatase activity
ISU57_RS03145	COG4771	TonB-dependent receptor
ISU57_RS03150	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU57_RS03155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU57_RS03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_RS03210	COG5001	Diguanylate cyclase
ISU57_RS03220	COG2211	Major facilitator Superfamily
ISU57_RS03270	COG2771	luxR family
ISU57_RS03275	COG3916	Acyl-homoserine-lactone synthase
ISU57_RS03395	COG1982	Orn Lys Arg decarboxylase major
ISU57_RS03400	COG1879	ABC-type sugar transport system periplasmic component
ISU57_RS03405	COG1129	ABC transporter
ISU57_RS03410	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS03415	COG4774	siderophore transport
ISU57_RS03435	COG1194	a g-specific adenine glycosylase
ISU57_RS03445	COG3171	Protein conserved in bacteria
ISU57_RS03465	COG3064	Membrane
ISU57_RS03465	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU57_RS03465	COG1073	alpha beta
ISU57_RS03470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU57_RS03475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU57_RS03485	COG0762	integral membrane protein
ISU57_RS03490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU57_RS03495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU57_RS03500	COG2805	Type II/IV secretion system protein
ISU57_RS03510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU57_RS03525	COG0189	ligase activity
ISU57_RS03530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU57_RS03535	COG2356	endonuclease I
ISU57_RS03550	COG1166	arginine decarboxylase activity
ISU57_RS03565	COG0501	Belongs to the peptidase M48B family
ISU57_RS03570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU57_RS03590	COG0191	fructose-bisphosphate aldolase activity
ISU57_RS03625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU57_RS03635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU57_RS03655	COG0006	proline dipeptidase activity
ISU57_RS03660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU57_RS03665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU57_RS03710	COG1272	protein, Hemolysin III
ISU57_RS03735	COG0745	RESPONSE REGULATOR receiver
ISU57_RS03740	COG2205	protein histidine kinase activity
ISU57_RS03745	COG4452	Inner membrane protein CreD
ISU57_RS03750	COG0716	FMN binding
ISU57_RS03755	COG4974	Belongs to the 'phage' integrase family
ISU57_RS03760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU57_RS03765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU57_RS03785	COG0582	viral genome integration into host DNA
ISU57_RS03810	COG2944	sequence-specific DNA binding
ISU57_RS03900	COG1695	Transcriptional regulator
ISU57_RS03905	COG0791	NLP P60 protein
ISU57_RS03915	COG1879	ABC-type sugar transport system periplasmic component
ISU57_RS03920	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS03925	COG1129	ABC transporter
ISU57_RS03935	COG2182	Extracellular solute-binding protein
ISU57_RS03940	COG1175	transmembrane transport
ISU57_RS03945	COG3833	ABC-type maltose transport systems, permease component
ISU57_RS03950	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU57_RS03955	COG1874	Beta-galactosidase
ISU57_RS03960	COG1263	PTS System
ISU57_RS03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_RS03980	COG2271	Major facilitator Superfamily
ISU57_RS04005	COG3119	arylsulfatase activity
ISU57_RS04010	COG0641	radical SAM
ISU57_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS04030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS04035	COG3716	PTS system mannose fructose sorbose family IID component
ISU57_RS04040	COG3715	PTS system
ISU57_RS04045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_RS04050	COG2222	sugar isomerase
ISU57_RS04060	COG1349	DNA-binding transcription factor activity
ISU57_RS04065	COG3119	arylsulfatase activity
ISU57_RS04105	COG0288	reversible hydration of carbon dioxide
ISU57_RS04125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU57_RS04145	COG2165	general secretion pathway protein
ISU57_RS04190	COG0840	transmembrane signaling receptor activity
ISU57_RS04205	COG0583	DNA-binding transcription factor activity
ISU57_RS04210	COG2814	Major facilitator Superfamily
ISU57_RS04215	COG0583	DNA-binding transcription factor activity
ISU57_RS04225	COG1609	Transcriptional regulator
ISU57_RS04255	COG0667	Aldo Keto reductase
ISU57_RS04305	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU57_RS04315	COG1074	ATP-dependent DNA helicase activity
ISU57_RS04320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU57_RS04330	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU57_RS04345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU57_RS04350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU57_RS04355	COG2166	iron-sulfur cluster assembly
ISU57_RS04360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU57_RS04370	COG0583	DNA-binding transcription factor activity
ISU57_RS04375	COG2363	Small membrane protein
ISU57_RS04400	COG1611	Belongs to the LOG family
ISU57_RS04420	COG3098	single-species biofilm formation
ISU57_RS04425	COG0564	pseudouridine synthase activity
ISU57_RS04485	COG0575	Belongs to the CDS family
ISU57_RS04490	COG0750	zinc metalloprotease
ISU57_RS04505	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU57_RS04530	COG0587	DNA-directed DNA polymerase activity
ISU57_RS04540	COG0346	lactoylglutathione lyase activity
ISU57_RS04545	COG0037	tRNA processing
ISU57_RS04555	COG4568	rho-dependent transcription termination
ISU57_RS04565	COG4681	YaeQ
ISU57_RS04575	COG3015	lipoprotein NlpE involved in copper resistance
ISU57_RS04585	COG1720	tRNA m6t6A37 methyltransferase activity
ISU57_RS04595	COG1464	Belongs to the NlpA lipoprotein family
ISU57_RS04600	COG2011	ABC-type metal ion transport system permease component
ISU57_RS04610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU57_RS04640	COG0656	L-ascorbic acid biosynthetic process
ISU57_RS04655	COG1388	LysM domain
ISU57_RS04655	COG0741	lytic transglycosylase activity
ISU57_RS04660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU57_RS04665	COG2226	methyltransferase
ISU57_RS04685	COG1953	Uracil, thiamine, allantoin
ISU57_RS04710	COG3657	addiction module killer protein
ISU57_RS04760	COG0582	viral genome integration into host DNA
ISU57_RS04780	COG2867	negative regulation of translational initiation
ISU57_RS04790	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU57_RS04795	COG0497	DNA recombination
ISU57_RS04800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU57_RS04815	COG2009	succinate dehydrogenase
ISU57_RS04820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU57_RS04825	COG1053	succinate dehydrogenase
ISU57_RS04835	COG0567	Dehydrogenase, E1 component
ISU57_RS04840	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU57_RS04850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU57_RS04855	COG1271	oxidase subunit
ISU57_RS04860	COG1294	oxidase, subunit
ISU57_RS04865	COG4890	Cyd operon protein YbgT
ISU57_RS04870	COG3790	cyd operon protein YbgE
ISU57_RS04875	COG0824	Thioesterase
ISU57_RS04880	COG0811	peptide transport
ISU57_RS04885	COG0848	biopolymer transport protein
ISU57_RS04890	COG3064	Membrane
ISU57_RS04890	COG3064	Membrane
ISU57_RS04900	COG2885	chlorophyll binding
ISU57_RS04905	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU57_RS04935	COG1230	cation diffusion facilitator family transporter
ISU57_RS04940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU57_RS04955	COG2017	converts alpha-aldose to the beta-anomer
ISU57_RS04970	COG1085	galactose-1-phosphate uridylyltransferase
ISU57_RS04975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU57_RS04985	COG1119	ATPase activity
ISU57_RS04990	COG2005	Transcriptional regulator
ISU57_RS04990	COG3585	molybdate ion transport
ISU57_RS05000	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU57_RS05005	COG4149	molybdate abc transporter
ISU57_RS05015	COG0561	phosphatase activity
ISU57_RS05040	COG2226	methyltransferase
ISU57_RS05050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU57_RS05060	COG4628	conserved protein (DUF2132)
ISU57_RS05065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU57_RS05070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU57_RS05080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU57_RS05085	COG0314	molybdopterin synthase activity
ISU57_RS05090	COG0670	Belongs to the BI1 family
ISU57_RS05105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU57_RS05115	COG1686	Belongs to the peptidase S11 family
ISU57_RS05120	COG0277	FAD linked oxidase domain protein
ISU57_RS05140	COG2261	transglycosylase associated protein
ISU57_RS05150	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU57_RS05165	COG4807	Protein conserved in bacteria
ISU57_RS05185	COG1122	ATPase activity
ISU57_RS05205	COG2897	thiosulfate sulfurtransferase activity
ISU57_RS05210	COG1732	Glycine betaine
ISU57_RS05215	COG1732	Glycine betaine
ISU57_RS05220	COG1174	glycine betaine transport
ISU57_RS05225	COG1125	glycine betaine transport
ISU57_RS05230	COG1174	glycine betaine transport
ISU57_RS05235	COG0531	amino acid
ISU57_RS05240	COG1982	Orn Lys Arg decarboxylase major
ISU57_RS05250	COG0697	spore germination
ISU57_RS05275	COG0814	amino acid
ISU57_RS05290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_RS05315	COG0784	Response regulator, receiver
ISU57_RS05315	COG2205	protein histidine kinase activity
ISU57_RS05325	COG2198	Histidine kinase
ISU57_RS05325	COG0642	Histidine kinase
ISU57_RS05330	COG2198	Histidine kinase
ISU57_RS05330	COG0642	Histidine kinase
ISU57_RS05335	COG2223	nitrite transmembrane transporter activity
ISU57_RS05360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU57_RS05400	COG3395	kinase activity
ISU57_RS05410	COG1349	DNA-binding transcription factor activity
ISU57_RS05415	COG3622	Belongs to the hyi family
ISU57_RS05435	COG4386	tail sheath protein
ISU57_RS05475	COG3299	homolog of phage Mu protein gp47
ISU57_RS05495	COG1737	Transcriptional regulator
ISU57_RS05500	COG2723	6-phospho-beta-galactosidase activity
ISU57_RS05520	COG3157	Type VI secretion system effector, Hcp
ISU57_RS05535	COG3083	sulfuric ester hydrolase activity
ISU57_RS05540	COG3082	Protein of unknown function (DUF1414)
ISU57_RS05560	COG1061	Type III restriction enzyme res subunit
ISU57_RS05565	COG1187	pseudouridine synthase activity
ISU57_RS05570	COG2814	Major facilitator Superfamily
ISU57_RS05580	COG4172	Belongs to the ABC transporter superfamily
ISU57_RS05585	COG4239	(ABC) transporter, permease
ISU57_RS05590	COG4174	ABC transporter (Permease)
ISU57_RS05595	COG4166	transmembrane transport
ISU57_RS05600	COG2200	EAL domain
ISU57_RS05605	COG0791	NLP P60 protein
ISU57_RS05610	COG0671	phosphoesterase, PA-phosphatase related
ISU57_RS05615	COG0523	cobalamin synthesis protein
ISU57_RS05625	COG2186	Transcriptional regulator
ISU57_RS05630	COG0246	Mannitol dehydrogenase
ISU57_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS05690	COG1129	ABC transporter
ISU57_RS05700	COG0494	nUDIX hydrolase
ISU57_RS05710	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU57_RS05715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_RS05715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_RS05715	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU57_RS05720	COG3710	Transcriptional regulator
ISU57_RS05735	COG3121	Chaperone
ISU57_RS05740	COG3188	usher protein
ISU57_RS05750	COG2855	membrane
ISU57_RS05755	COG0583	DNA-binding transcription factor activity
ISU57_RS05760	COG0833	amino acid
ISU57_RS05770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS05780	COG4771	TonB-dependent receptor
ISU57_RS05785	COG0625	glutathione transferase activity
ISU57_RS05810	COG2011	ABC-type metal ion transport system permease component
ISU57_RS05815	COG1686	Belongs to the peptidase S11 family
ISU57_RS05825	COG0814	amino acid
ISU57_RS05830	COG1349	DNA-binding transcription factor activity
ISU57_RS05840	COG0671	phosphoesterase, PA-phosphatase related
ISU57_RS05870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU57_RS05875	COG3842	ATPase activity
ISU57_RS05880	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU57_RS05885	COG1177	transmembrane transport
ISU57_RS05900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS05925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS05930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS05935	COG1120	ATPase activity
ISU57_RS05960	COG4160	amino acid transport
ISU57_RS05965	COG4215	(ABC) transporter
ISU57_RS05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS05975	COG1126	abc transporter atp-binding protein
ISU57_RS05980	COG1605	Chorismate mutase
ISU57_RS05990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_RS05995	COG0702	epimerase
ISU57_RS06000	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU57_RS06010	COG0028	Belongs to the TPP enzyme family
ISU57_RS06015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_RS06025	COG2431	L-lysine efflux transmembrane transporter activity
ISU57_RS06030	COG3593	DNA synthesis involved in DNA repair
ISU57_RS06035	COG2990	Protein conserved in bacteria
ISU57_RS06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_RS06050	COG1278	Cold shock
ISU57_RS06060	COG0542	response to heat
ISU57_RS06070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU57_RS06080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU57_RS06090	COG0492	ferredoxin-NADP+ reductase activity
ISU57_RS06100	COG3107	peptidoglycan biosynthetic process
ISU57_RS06100	COG1674	ftsk spoiiie
ISU57_RS06110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU57_RS06140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU57_RS06150	COG1882	Formate acetyltransferase
ISU57_RS06155	COG2116	formate transmembrane transporter activity
ISU57_RS06160	COG1944	ATP diphosphatase activity
ISU57_RS06165	COG0252	asparaginase activity
ISU57_RS06170	COG5295	Hep Hag repeat protein
ISU57_RS06170	COG5295	Hep Hag repeat protein
ISU57_RS06195	COG0539	negative regulation of cytoplasmic translation
ISU57_RS06205	COG0658	competence protein
ISU57_RS06205	COG2333	competence protein COMEC
ISU57_RS06220	COG5383	Protein conserved in bacteria
ISU57_RS06225	COG1278	Cold shock
ISU57_RS06240	COG3173	Aminoglycoside phosphotransferase
ISU57_RS06245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU57_RS06270	COG2989	Protein conserved in bacteria
ISU57_RS06275	COG3108	Peptidase M15
ISU57_RS06280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU57_RS06290	COG1448	Aminotransferase
ISU57_RS06310	COG0308	aminopeptidase N
ISU57_RS06325	COG0633	Ferredoxin
ISU57_RS06325	COG3217	Mosc domain protein beta barrel domain protein
ISU57_RS06335	COG0488	(ABC) transporter
ISU57_RS06340	COG2995	paraquat-inducible protein a
ISU57_RS06345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU57_RS06345	COG3008	intermembrane lipid transfer
ISU57_RS06350	COG3009	Protein conserved in bacteria
ISU57_RS06355	COG3130	regulation of translation
ISU57_RS06395	COG1067	ATP-dependent peptidase activity
ISU57_RS06420	COG3070	regulator of competence-specific genes
ISU57_RS06425	COG1289	transmembrane transporter activity
ISU57_RS06430	COG3304	Inner membrane component domain
ISU57_RS06435	COG0210	DNA helicase
ISU57_RS06450	COG1832	CoA-binding protein
ISU57_RS06470	COG2920	part of a sulfur-relay system
ISU57_RS06495	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS06505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU57_RS06510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU57_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS06520	COG3425	synthase
ISU57_RS06530	COG1024	Enoyl-CoA hydratase
ISU57_RS06535	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS06545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU57_RS06550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU57_RS06680	COG0488	(ABC) transporter
ISU57_RS06690	COG3328	transposase activity
ISU57_RS06700	COG0303	'Molybdopterin
ISU57_RS06710	COG1136	(ABC) transporter
ISU57_RS06740	COG0583	DNA-binding transcription factor activity
ISU57_RS06745	COG0477	Major facilitator Superfamily
ISU57_RS06755	COG2311	Membrane
ISU57_RS06770	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS06775	COG2949	membrane
ISU57_RS06790	COG1346	cytolysis
ISU57_RS06800	COG2814	Major facilitator Superfamily
ISU57_RS06830	COG0489	protein tyrosine kinase activity
ISU57_RS06845	COG2982	Protein involved in outer membrane biogenesis
ISU57_RS06850	COG1253	flavin adenine dinucleotide binding
ISU57_RS06855	COG4114	ferric iron reductase
ISU57_RS06860	COG0076	glutamate decarboxylase activity
ISU57_RS06865	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU57_RS06880	COG1120	ATPase activity
ISU57_RS06885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS06890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS06895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU57_RS06910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU57_RS06915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU57_RS06925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU57_RS06925	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU57_RS06945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU57_RS06945	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU57_RS06955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU57_RS06970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_RS06985	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS06990	COG1129	ABC transporter
ISU57_RS06995	COG1129	ABC transporter
ISU57_RS07000	COG0371	Dehydrogenase
ISU57_RS07005	COG0531	amino acid
ISU57_RS07015	COG2925	Exonuclease
ISU57_RS07030	COG3328	transposase activity
ISU57_RS07035	COG1388	LysM domain
ISU57_RS07035	COG1470	cell adhesion involved in biofilm formation
ISU57_RS07040	COG2271	Major facilitator Superfamily
ISU57_RS07045	COG3011	Protein conserved in bacteria
ISU57_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS07060	COG4948	Mandelate Racemase Muconate Lactonizing
ISU57_RS07075	COG0534	Mate efflux family protein
ISU57_RS07095	COG3122	Protein conserved in bacteria
ISU57_RS07120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU57_RS07140	COG2223	nitrite transmembrane transporter activity
ISU57_RS07145	COG3328	transposase activity
ISU57_RS07170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_RS07170	COG1017	nitric oxide dioxygenase activity
ISU57_RS07190	COG2814	Major facilitator Superfamily
ISU57_RS07195	COG3711	transcriptional antiterminator
ISU57_RS07200	COG3683	transport system, periplasmic component
ISU57_RS07205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU57_RS07225	COG1104	cysteine desulfurase activity
ISU57_RS07230	COG0822	iron-sulfur transferase activity
ISU57_RS07250	COG0633	Ferredoxin
ISU57_RS07255	COG2975	iron-sulfur cluster assembly
ISU57_RS07280	COG3468	outer membrane autotransporter barrel domain protein
ISU57_RS07285	COG3468	outer membrane autotransporter barrel domain protein
ISU57_RS07325	COG2976	Protein conserved in bacteria
ISU57_RS07330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU57_RS07345	COG1645	bacterial-type flagellum-dependent swarming motility
ISU57_RS07355	COG0517	IMP dehydrogenase activity
ISU57_RS07355	COG0516	GMP reductase activity
ISU57_RS07400	COG3328	transposase activity
ISU57_RS07415	COG0351	phosphomethylpyrimidine kinase
ISU57_RS07445	COG0826	peptidase U32
ISU57_RS07450	COG3422	double-strand break repair
ISU57_RS07455	COG0745	RESPONSE REGULATOR receiver
ISU57_RS07485	COG3842	ATPase activity
ISU57_RS07495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU57_RS07505	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU57_RS07510	COG1177	transmembrane transport
ISU57_RS07515	COG0443	Heat shock 70 kDa protein
ISU57_RS07520	COG2239	Acts as a magnesium transporter
ISU57_RS07535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU57_RS07545	COG0581	inorganic phosphate transmembrane transporter activity
ISU57_RS07560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU57_RS07565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU57_RS07590	COG1393	Belongs to the ArsC family
ISU57_RS07595	COG4783	chaperone-mediated protein folding
ISU57_RS07600	COG0628	permease
ISU57_RS07610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU57_RS07615	COG2716	regulation of RNA biosynthetic process
ISU57_RS07625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU57_RS07640	COG2321	neutral zinc metallopeptidase
ISU57_RS07660	COG1876	peptidase activity
ISU57_RS07670	COG1393	Belongs to the ArsC family
ISU57_RS07685	COG1175	transmembrane transport
ISU57_RS07690	COG3842	ATPase activity
ISU57_RS07700	COG3119	arylsulfatase activity
ISU57_RS07705	COG0641	radical SAM
ISU57_RS07710	COG1988	membrane-bound metal-dependent
ISU57_RS07720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_RS07730	COG2197	response regulator
ISU57_RS07735	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_RS07735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_RS07740	COG3062	negative regulation of establishment of protein localization
ISU57_RS07750	COG3043	anaerobic respiration
ISU57_RS07755	COG3005	denitrification pathway
ISU57_RS07795	COG3111	PFAM Bacterial OB fold (BOF) protein
ISU57_RS07805	COG2837	iron assimilation
ISU57_RS07810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU57_RS07820	COG4886	Leucine-rich repeat (LRR) protein
ISU57_RS07830	COG2731	YhcH YjgK YiaL family protein
ISU57_RS07835	COG1737	Transcriptional regulator
ISU57_RS07845	COG4150	thiosulfate binding
ISU57_RS07850	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU57_RS07855	COG4208	sulfate ABC transporter
ISU57_RS07860	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU57_RS07875	COG0745	RESPONSE REGULATOR receiver
ISU57_RS07880	COG3850	Histidine kinase
ISU57_RS07880	COG5002	protein histidine kinase activity
ISU57_RS07890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU57_RS07910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU57_RS07925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_RS07930	COG0745	RESPONSE REGULATOR receiver
ISU57_RS07935	COG2205	protein histidine kinase activity
ISU57_RS07955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS07965	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU57_RS07980	COG3530	Putative quorum-sensing-regulated virulence factor
ISU57_RS08045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU57_RS08060	COG0667	Aldo Keto reductase
ISU57_RS08085	COG0436	Aminotransferase
ISU57_RS08090	COG3038	cytochrome b561
ISU57_RS08120	COG3381	protein complex oligomerization
ISU57_RS08125	COG3302	dmso reductase anchor subunit
ISU57_RS08130	COG0437	4 iron, 4 sulfur cluster binding
ISU57_RS08135	COG0243	molybdopterin cofactor binding
ISU57_RS08170	COG2951	lytic endotransglycosylase activity
ISU57_RS08235	COG3121	Chaperone
ISU57_RS08240	COG3188	usher protein
ISU57_RS08245	COG3328	transposase activity
ISU57_RS08250	COG3188	usher protein
ISU57_RS08340	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU57_RS08350	COG1704	LemA family
ISU57_RS08370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU57_RS08375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU57_RS08380	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU57_RS08390	COG1138	Cytochrome C-type biogenesis protein
ISU57_RS08395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU57_RS08400	COG4235	cytochrome complex assembly
ISU57_RS08400	COG3088	subunit of a heme lyase
ISU57_RS08405	COG3088	subunit of a heme lyase
ISU57_RS08405	COG4235	cytochrome complex assembly
ISU57_RS08420	COG3691	Protein conserved in bacteria
ISU57_RS08435	COG2062	phosphohistidine phosphatase, SixA
ISU57_RS08445	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU57_RS08460	COG0730	response to heat
ISU57_RS08465	COG3101	peptidyl-lysine hydroxylation
ISU57_RS08480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU57_RS08485	COG1794	racemase activity, acting on amino acids and derivatives
ISU57_RS08500	COG0697	spore germination
ISU57_RS08515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU57_RS08525	COG0586	Pfam SNARE associated Golgi protein
ISU57_RS08535	COG0285	dihydrofolate synthase activity
ISU57_RS08540	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU57_RS08545	COG1286	toxin biosynthetic process
ISU57_RS08550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU57_RS08560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS08565	COG4215	(ABC) transporter
ISU57_RS08570	COG4160	amino acid transport
ISU57_RS08575	COG4598	ABC transporter
ISU57_RS08580	COG1090	epimerase
ISU57_RS08590	COG0622	Phosphoesterase
ISU57_RS08595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU57_RS08600	COG3037	sugar-specific permease SgaT UlaA
ISU57_RS08615	COG1609	Transcriptional regulator
ISU57_RS08620	COG0280	phosphate acetyltransferase
ISU57_RS08620	COG0857	belongs to the CobB CobQ family
ISU57_RS08640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_RS08645	COG0471	metal ion transport
ISU57_RS08645	COG0490	domain, Protein
ISU57_RS08660	COG0436	Aminotransferase
ISU57_RS08665	COG0583	DNA-binding transcription factor activity
ISU57_RS08675	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU57_RS08695	COG1034	ATP synthesis coupled electron transport
ISU57_RS08710	COG0839	Belongs to the complex I subunit 6 family
ISU57_RS08720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU57_RS08725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU57_RS08745	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS08750	COG3265	gluconokinase activity
ISU57_RS08765	COG1649	PFAM Uncharacterised BCR, COG1649
ISU57_RS08770	COG1609	Transcriptional regulator
ISU57_RS08775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU57_RS08790	COG0129	dihydroxy-acid dehydratase activity
ISU57_RS08795	COG4575	ribosome binding
ISU57_RS08805	COG1169	isochorismate synthase
ISU57_RS08820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU57_RS08835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU57_RS08870	COG1126	abc transporter atp-binding protein
ISU57_RS08875	COG0765	amino acid transport
ISU57_RS08880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS08910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU57_RS08930	COG1063	alcohol dehydrogenase
ISU57_RS08935	COG1879	ABC-type sugar transport system periplasmic component
ISU57_RS08940	COG1129	ABC transporter
ISU57_RS08945	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS08950	COG1609	Transcriptional regulator
ISU57_RS08955	COG0583	DNA-binding transcription factor activity
ISU57_RS08960	COG0473	3-isopropylmalate dehydrogenase activity
ISU57_RS08970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU57_RS08980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_RS08985	COG2831	hemolysin activation secretion protein
ISU57_RS08990	COG3210	domain, Protein
ISU57_RS09030	COG3210	domain, Protein
ISU57_RS09040	COG3842	ATPase activity
ISU57_RS09050	COG1609	Transcriptional regulator
ISU57_RS09065	COG0395	ABC-type sugar transport system, permease component
ISU57_RS09070	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU57_RS09095	COG0668	transmembrane transport
ISU57_RS09100	COG1518	maintenance of DNA repeat elements
ISU57_RS09105	COG1203	CRISPR-associated helicase, Cas3
ISU57_RS09130	COG0667	Aldo Keto reductase
ISU57_RS09140	COG0477	Major facilitator Superfamily
ISU57_RS09150	COG0583	DNA-binding transcription factor activity
ISU57_RS09155	COG2771	luxR family
ISU57_RS09160	COG3916	Acyl-homoserine-lactone synthase
ISU57_RS09180	COG0628	permease
ISU57_RS09200	COG3328	transposase activity
ISU57_RS09210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU57_RS09230	COG3328	transposase activity
ISU57_RS09235	COG1530	ribonuclease E activity
ISU57_RS09240	COG0564	pseudouridine synthase activity
ISU57_RS09245	COG0424	maF-like protein
ISU57_RS09250	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU57_RS09255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU57_RS09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU57_RS09295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU57_RS09300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU57_RS09310	COG0470	DNA polymerase III
ISU57_RS09315	COG0084	hydrolase, TatD family'
ISU57_RS09320	COG1263	PTS System
ISU57_RS09320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_RS09330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU57_RS09335	COG0537	adenosine 5'-monophosphoramidase activity
ISU57_RS09340	COG5633	Lipoprotein
ISU57_RS09355	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU57_RS09365	COG1252	NADH dehydrogenase
ISU57_RS09380	COG3328	transposase activity
ISU57_RS09385	COG3134	Outer membrane lipoprotein
ISU57_RS09390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU57_RS09395	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU57_RS09405	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU57_RS09410	COG1940	carbohydrate kinase activity
ISU57_RS09430	COG2850	peptidyl-arginine hydroxylation
ISU57_RS09440	COG0745	RESPONSE REGULATOR receiver
ISU57_RS09450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU57_RS09470	COG1187	pseudouridine synthase activity
ISU57_RS09475	COG0538	isocitrate dehydrogenase activity
ISU57_RS09490	COG0840	transmembrane signaling receptor activity
ISU57_RS09495	COG0702	epimerase
ISU57_RS09500	COG1733	regulation of RNA biosynthetic process
ISU57_RS09525	COG1522	sequence-specific DNA binding
ISU57_RS09540	COG3321	synthase
ISU57_RS09540	COG0604	alcohol dehydrogenase
ISU57_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS09565	COG1285	pathogenesis
ISU57_RS09590	COG1360	Flagellar Motor Protein
ISU57_RS09595	COG0643	Histidine kinase
ISU57_RS09595	COG2198	Histidine kinase
ISU57_RS09600	COG0835	chemotaxis
ISU57_RS09605	COG2271	Major facilitator Superfamily
ISU57_RS09610	COG0251	oxidation-reduction process
ISU57_RS09620	COG2964	Protein conserved in bacteria
ISU57_RS09640	COG0840	transmembrane signaling receptor activity
ISU57_RS09645	COG0840	transmembrane signaling receptor activity
ISU57_RS09650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU57_RS09660	COG0745	RESPONSE REGULATOR receiver
ISU57_RS09665	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU57_RS09670	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU57_RS09680	COG5295	Hep Hag repeat protein
ISU57_RS09690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU57_RS09745	COG3121	Chaperone
ISU57_RS09765	COG3008	intermembrane lipid transfer
ISU57_RS09770	COG2995	paraquat-inducible protein a
ISU57_RS09775	COG1956	GAF domain-containing protein
ISU57_RS09785	COG0793	Belongs to the peptidase S41A family
ISU57_RS09795	COG3539	Fimbrial protein
ISU57_RS09800	COG3121	Chaperone
ISU57_RS09815	COG3121	Chaperone
ISU57_RS09820	COG2814	Major facilitator Superfamily
ISU57_RS09825	COG0823	Involved in the tonB-independent uptake of proteins
ISU57_RS09835	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU57_RS09840	COG1823	symporter activity
ISU57_RS09845	COG1988	membrane-bound metal-dependent
ISU57_RS09850	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU57_RS09855	COG1653	transport
ISU57_RS09860	COG3842	ATPase activity
ISU57_RS09865	COG0395	ABC-type sugar transport system, permease component
ISU57_RS09870	COG1175	transmembrane transport
ISU57_RS09880	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS09890	COG1917	Cupin 2, conserved barrel domain protein
ISU57_RS09895	COG3328	transposase activity
ISU57_RS09915	COG0500	methyltransferase
ISU57_RS09960	COG5002	protein histidine kinase activity
ISU57_RS10010	COG0012	GTP binding
ISU57_RS10025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU57_RS10050	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU57_RS10070	COG0659	secondary active sulfate transmembrane transporter activity
ISU57_RS10090	COG3833	ABC-type maltose transport systems, permease component
ISU57_RS10095	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU57_RS10115	COG0584	glycerophosphoryl diester phosphodiesterase
ISU57_RS10120	COG1940	carbohydrate kinase activity
ISU57_RS10135	COG3381	protein complex oligomerization
ISU57_RS10150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU57_RS10160	COG0728	peptidoglycan biosynthetic process
ISU57_RS10180	COG3102	Protein conserved in bacteria
ISU57_RS10200	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU57_RS10205	COG1801	Protein of unknown function DUF72
ISU57_RS10215	COG0494	nUDIX hydrolase
ISU57_RS10240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU57_RS10250	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU57_RS10255	COG0739	heme binding
ISU57_RS10260	COG1560	Kdo2-lipid A biosynthetic process
ISU57_RS10270	COG0469	pyruvate kinase activity
ISU57_RS10275	COG1737	Transcriptional regulator
ISU57_RS10280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU57_RS10285	COG0800	Aldolase
ISU57_RS10300	COG0251	oxidation-reduction process
ISU57_RS10305	COG1199	ATP-dependent helicase activity
ISU57_RS10315	COG3065	identical protein binding
ISU57_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
ISU57_RS10330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISU57_RS10335	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU57_RS10340	COG2894	cell division
ISU57_RS10355	COG2951	lytic endotransglycosylase activity
ISU57_RS10360	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU57_RS10370	COG0582	viral genome integration into host DNA
ISU57_RS10470	COG3328	transposase activity
ISU57_RS10630	COG3328	transposase activity
ISU57_RS10640	COG1104	cysteine desulfurase activity
ISU57_RS10670	COG2719	SpoVR family
ISU57_RS10680	COG2814	Major facilitator Superfamily
ISU57_RS10690	COG0583	DNA-binding transcription factor activity
ISU57_RS10705	COG2766	serine protein kinase
ISU57_RS10710	COG3713	MltA-interacting MipA family protein
ISU57_RS10730	COG3139	Protein of unknown function (DUF1315)
ISU57_RS10735	COG1335	isochorismatase
ISU57_RS10740	COG0252	asparaginase activity
ISU57_RS10745	COG0616	signal peptide processing
ISU57_RS10750	COG0778	Nitroreductase
ISU57_RS10755	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU57_RS10760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU57_RS10770	COG0494	nUDIX hydrolase
ISU57_RS10775	COG0708	Exodeoxyribonuclease III
ISU57_RS10780	COG0583	DNA-binding transcription factor activity
ISU57_RS10800	COG3328	transposase activity
ISU57_RS10805	COG0788	formyltetrahydrofolate deformylase activity
ISU57_RS10815	COG0745	RESPONSE REGULATOR receiver
ISU57_RS10850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU57_RS10855	COG2205	protein histidine kinase activity
ISU57_RS10860	COG0745	RESPONSE REGULATOR receiver
ISU57_RS10870	COG0531	amino acid
ISU57_RS10880	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU57_RS10885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU57_RS10890	COG0589	response to stress
ISU57_RS10895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU57_RS10900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU57_RS10915	COG1011	Hydrolase
ISU57_RS10920	COG0440	acetolactate synthase activity
ISU57_RS10925	COG0028	Belongs to the TPP enzyme family
ISU57_RS10955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU57_RS10965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU57_RS10985	COG1609	Transcriptional regulator
ISU57_RS10990	COG0038	chloride channel
ISU57_RS10995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU57_RS11000	COG1940	carbohydrate kinase activity
ISU57_RS11005	COG0583	DNA-binding transcription factor activity
ISU57_RS11010	COG2814	Major facilitator Superfamily
ISU57_RS11020	COG0114	fumarate hydratase activity
ISU57_RS11030	COG5339	Protein conserved in bacteria
ISU57_RS11040	COG0385	Bile acid
ISU57_RS11045	COG0673	inositol 2-dehydrogenase activity
ISU57_RS11055	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS11060	COG1129	ABC transporter
ISU57_RS11065	COG1879	ABC-type sugar transport system periplasmic component
ISU57_RS11080	COG2274	protein secretion by the type I secretion system
ISU57_RS11085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_RS11095	COG2274	protein secretion by the type I secretion system
ISU57_RS11130	COG2207	Transcriptional regulator
ISU57_RS11130	COG3708	Transcriptional regulator
ISU57_RS11135	COG4658	electron transport chain
ISU57_RS11140	COG4659	FMN binding
ISU57_RS11150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU57_RS11155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_RS11160	COG2271	Major facilitator Superfamily
ISU57_RS11170	COG1966	Carbon starvation protein
ISU57_RS11175	COG2879	small protein
ISU57_RS11180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU57_RS11200	COG0023	Translation Initiation Factor
ISU57_RS11215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU57_RS11220	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU57_RS11225	COG0671	phosphoesterase, PA-phosphatase related
ISU57_RS11235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISU57_RS11245	COG0583	DNA-binding transcription factor activity
ISU57_RS11265	COG0616	signal peptide processing
ISU57_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS11280	COG1187	pseudouridine synthase activity
ISU57_RS11285	COG0009	L-threonylcarbamoyladenylate synthase
ISU57_RS11305	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU57_RS11315	COG0135	phosphoribosylanthranilate isomerase activity
ISU57_RS11315	COG0134	indole-3-glycerol-phosphate synthase activity
ISU57_RS11335	COG3047	cAMP biosynthetic process
ISU57_RS11370	COG3328	transposase activity
ISU57_RS11375	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU57_RS11380	COG2350	Protein conserved in bacteria
ISU57_RS11425	COG4608	Belongs to the ABC transporter superfamily
ISU57_RS11430	COG0444	Belongs to the ABC transporter superfamily
ISU57_RS11435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_RS11440	COG0601	transmembrane transport
ISU57_RS11450	COG2095	MarC family integral membrane protein
ISU57_RS11455	COG1012	belongs to the aldehyde dehydrogenase family
ISU57_RS11455	COG1454	alcohol dehydrogenase
ISU57_RS11495	COG3591	Belongs to the peptidase S1B family
ISU57_RS11510	COG1643	Atp-dependent helicase
ISU57_RS11520	COG2390	Transcriptional regulator
ISU57_RS11525	COG0246	Mannitol dehydrogenase
ISU57_RS11530	COG3784	Protein of unknown function (DUF1318)
ISU57_RS11540	COG2911	Protein conserved in bacteria
ISU57_RS11545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU57_RS11550	COG3187	Heat shock protein
ISU57_RS11555	COG3042	response to heat
ISU57_RS11560	COG1285	pathogenesis
ISU57_RS11570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU57_RS11570	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU57_RS11570	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU57_RS11570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU57_RS11580	COG0657	acetylesterase activity
ISU57_RS11595	COG4166	transmembrane transport
ISU57_RS11600	COG2866	Carboxypeptidase
ISU57_RS11605	COG4948	Mandelate Racemase Muconate Lactonizing
ISU57_RS11610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU57_RS11625	COG5642	Protein of unknown function (DUF2384)
ISU57_RS11630	COG5654	RES domain protein
ISU57_RS11640	COG3106	COG3106 Predicted ATPase
ISU57_RS11650	COG1983	PspC domain protein
ISU57_RS11660	COG1842	Phage shock protein A
ISU57_RS11665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU57_RS11675	COG4166	transmembrane transport
ISU57_RS11680	COG4168	peptide transport system, permease
ISU57_RS11685	COG4171	peptide transport system, permease
ISU57_RS11695	COG4172	Belongs to the ABC transporter superfamily
ISU57_RS11700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU57_RS11700	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU57_RS11705	COG3104	oligopeptide transport
ISU57_RS11720	COG0625	glutathione transferase activity
ISU57_RS11740	COG3895	Periplasmic Protein
ISU57_RS11750	COG3133	Outer membrane lipoprotein
ISU57_RS11760	COG2194	sulfuric ester hydrolase activity
ISU57_RS11765	COG1309	transcriptional regulator
ISU57_RS11775	COG0346	lactoylglutathione lyase activity
ISU57_RS11780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU57_RS11790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU57_RS11795	COG0791	NLP P60 protein
ISU57_RS11815	COG0583	DNA-binding transcription factor activity
ISU57_RS11820	COG2814	Major facilitator Superfamily
ISU57_RS11825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU57_RS11830	COG0307	riboflavin synthase, alpha
ISU57_RS11885	COG1388	LysM domain
ISU57_RS11885	COG1376	ErfK ybiS ycfS ynhG family protein
ISU57_RS11900	COG0719	Fe-S assembly protein
ISU57_RS11905	COG0396	ATPase activity
ISU57_RS11910	COG0719	Fe-S assembly protein
ISU57_RS11915	COG0316	Belongs to the HesB IscA family
ISU57_RS11920	COG2050	protein possibly involved in aromatic compounds catabolism
ISU57_RS11925	COG0277	FAD linked oxidase domain protein
ISU57_RS11925	COG0247	lactate metabolic process
ISU57_RS11930	COG0628	permease
ISU57_RS11940	COG0574	Belongs to the PEP-utilizing enzyme family
ISU57_RS11940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU57_RS11965	COG0791	NLP P60 protein
ISU57_RS12015	COG0386	Belongs to the glutathione peroxidase family
ISU57_RS12030	COG0776	regulation of translation
ISU57_RS12035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU57_RS12035	COG0072	phenylalanine-tRNA ligase activity
ISU57_RS12070	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU57_RS12090	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU57_RS12095	COG1121	(ABC) transporter
ISU57_RS12100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU57_RS12105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU57_RS12115	COG3001	Fructosamine kinase
ISU57_RS12125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_RS12130	COG3328	transposase activity
ISU57_RS12175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_RS12180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU57_RS12185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU57_RS12200	COG0402	S-adenosylhomocysteine deaminase activity
ISU57_RS12250	COG3842	ATPase activity
ISU57_RS12255	COG0395	ABC-type sugar transport system, permease component
ISU57_RS12260	COG1175	transmembrane transport
ISU57_RS12270	COG0673	inositol 2-dehydrogenase activity
ISU57_RS12275	COG2188	Transcriptional regulator
ISU57_RS12400	COG2197	response regulator
ISU57_RS12410	COG3136	membrane protein required for alginate biosynthesis
ISU57_RS12430	COG1113	amino acid transport
ISU57_RS12450	COG2822	iron ion transport
ISU57_RS12455	COG0672	)-iron permease
ISU57_RS12470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU57_RS12470	COG0506	proline dehydrogenase activity
ISU57_RS12470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU57_RS12485	COG1126	abc transporter atp-binding protein
ISU57_RS12490	COG0765	amino acid transport
ISU57_RS12495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS12510	COG1191	sigma factor activity
ISU57_RS12540	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU57_RS12545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU57_RS12550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU57_RS12570	COG1677	Flagellar hook-basal body complex protein FliE
ISU57_RS12590	COG1157	protein secretion by the type III secretion system
ISU57_RS12605	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU57_RS12630	COG1987	bacterial-type flagellum assembly
ISU57_RS12650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_RS12655	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS12660	COG1129	ABC transporter
ISU57_RS12670	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS12675	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS12675	COG3347	Dehydrogenase
ISU57_RS12680	COG2390	Transcriptional regulator
ISU57_RS12690	COG1256	bacterial-type flagellum assembly
ISU57_RS12730	COG1558	bacterial-type flagellum-dependent cell motility
ISU57_RS12735	COG1815	bacterial-type flagellum-dependent cell motility
ISU57_RS12745	COG2747	anti-sigma28 factor FlgM
ISU57_RS12750	COG3418	PFAM FlgN family protein
ISU57_RS12775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU57_RS12780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU57_RS12805	COG2372	response to copper ion
ISU57_RS12810	COG1528	Iron-storage protein
ISU57_RS12825	COG1770	oligopeptidase
ISU57_RS12840	COG3141	response to X-ray
ISU57_RS12845	COG0513	Belongs to the DEAD box helicase family
ISU57_RS12870	COG1760	l-serine dehydratase
ISU57_RS12875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU57_RS12880	COG2368	4-hydroxyphenylacetate
ISU57_RS12895	COG3971	2-oxopent-4-enoate hydratase activity
ISU57_RS12905	COG3384	dioxygenase
ISU57_RS12910	COG1012	belongs to the aldehyde dehydrogenase family
ISU57_RS12925	COG1846	Transcriptional regulator
ISU57_RS12930	COG1253	flavin adenine dinucleotide binding
ISU57_RS12935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_RS12935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS12940	COG3715	PTS system
ISU57_RS12945	COG3716	PTS system mannose fructose sorbose family IID component
ISU57_RS12975	COG2226	methyltransferase
ISU57_RS12980	COG1496	oxidoreductase activity
ISU57_RS13000	COG1113	amino acid transport
ISU57_RS13035	COG2207	Transcriptional regulator
ISU57_RS13045	COG1132	(ABC) transporter
ISU57_RS13090	COG0347	Belongs to the P(II) protein family
ISU57_RS13095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU57_RS13095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU57_RS13100	COG2204	response regulator
ISU57_RS13105	COG3170	Tfp pilus assembly protein FimV
ISU57_RS13110	COG2205	protein histidine kinase activity
ISU57_RS13155	COG0560	Phosphoserine phosphatase
ISU57_RS13165	COG1737	Transcriptional regulator
ISU57_RS13170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_RS13185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU57_RS13220	COG3086	response to oxidative stress
ISU57_RS13225	COG3026	antisigma factor binding
ISU57_RS13240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU57_RS13250	COG0513	Belongs to the DEAD box helicase family
ISU57_RS13295	COG1984	allophanate hydrolase subunit 2
ISU57_RS13310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU57_RS13315	COG5212	phosphodiesterase
ISU57_RS13325	COG3272	Protein of unknown function (DUF1722)
ISU57_RS13360	COG2205	protein histidine kinase activity
ISU57_RS13365	COG0745	RESPONSE REGULATOR receiver
ISU57_RS13380	COG0033	Phosphoglucomutase
ISU57_RS13385	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU57_RS13400	COG2169	Transcriptional regulator
ISU57_RS13400	COG1917	Cupin 2, conserved barrel domain protein
ISU57_RS13405	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU57_RS13410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU57_RS13415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU57_RS13425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU57_RS13435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU57_RS13445	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU57_RS13450	COG4413	Urea transporter
ISU57_RS13460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU57_RS13485	COG0831	urea catabolic process
ISU57_RS13490	COG1124	(ABC) transporter
ISU57_RS13495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU57_RS13500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_RS13510	COG0747	negative chemotaxis
ISU57_RS13515	COG1278	Cold shock
ISU57_RS13555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU57_RS13560	COG4175	Glycine betaine
ISU57_RS13565	COG4176	ABC-type proline glycine betaine transport system permease component
ISU57_RS13570	COG2113	Glycine betaine
ISU57_RS13605	COG0582	viral genome integration into host DNA
ISU57_RS13615	COG0596	Alpha beta hydrolase
ISU57_RS13630	COG0735	belongs to the Fur family
ISU57_RS13655	COG2190	(PTS) system
ISU57_RS13655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_RS13655	COG1263	PTS System
ISU57_RS13665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU57_RS13670	COG1846	Transcriptional regulator
ISU57_RS13670	COG1940	carbohydrate kinase activity
ISU57_RS13675	COG0647	UMP catabolic process
ISU57_RS13680	COG0367	asparagine synthase
ISU57_RS13715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU57_RS13720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU57_RS13725	COG1702	phosphate starvation-inducible protein PhoH
ISU57_RS13735	COG4535	Mg2 and Co2 transporter CorC
ISU57_RS13740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU57_RS13750	COG0765	amino acid transport
ISU57_RS13755	COG0765	amino acid transport
ISU57_RS13760	COG1126	abc transporter atp-binding protein
ISU57_RS13765	COG2888	peptidyl-tyrosine sulfation
ISU57_RS13780	COG1466	dna polymerase III delta subunit
ISU57_RS13790	COG0799	negative regulation of ribosome biogenesis
ISU57_RS13800	COG0768	penicillin binding
ISU57_RS13805	COG0772	Belongs to the SEDS family
ISU57_RS13810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU57_RS13815	COG1686	Belongs to the peptidase S11 family
ISU57_RS13835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU57_RS13840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU57_RS13850	COG1278	Cold shock
ISU57_RS13855	COG2197	response regulator
ISU57_RS13880	COG5265	(ABC) transporter
ISU57_RS13890	COG3718	enzyme involved in inositol metabolism
ISU57_RS13900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_RS13905	COG0673	inositol 2-dehydrogenase activity
ISU57_RS13910	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS13915	COG1129	ABC transporter
ISU57_RS13930	COG3962	Belongs to the TPP enzyme family
ISU57_RS13950	COG2373	Large extracellular alpha-helical protein
ISU57_RS13960	COG4953	penicillin-binding protein 1C
ISU57_RS13965	COG3423	Transcriptional regulator
ISU57_RS14020	COG3328	transposase activity
ISU57_RS14035	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU57_RS14045	COG0656	L-ascorbic acid biosynthetic process
ISU57_RS14050	COG0667	Aldo Keto reductase
ISU57_RS14080	COG2453	phosphatase
ISU57_RS14080	COG0671	phosphoesterase, PA-phosphatase related
ISU57_RS14085	COG2267	carboxylic ester hydrolase activity
ISU57_RS14095	COG4589	Belongs to the CDS family
ISU57_RS14100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU57_RS14110	COG0582	viral genome integration into host DNA
ISU57_RS14145	COG2501	S4 domain
ISU57_RS14160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU57_RS14170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU57_RS14175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU57_RS14180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU57_RS14185	COG4181	ATPase activity
ISU57_RS14190	COG2755	lipolytic protein G-D-S-L family
ISU57_RS14195	COG0300	oxidoreductase activity
ISU57_RS14200	COG3118	belongs to the thioredoxin family
ISU57_RS14205	COG0330	HflC and HflK could
ISU57_RS14210	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU57_RS14215	COG0789	Transcriptional regulator
ISU57_RS14220	COG2217	Heavy metal translocating P-type atpase
ISU57_RS14225	COG3735	TraB family
ISU57_RS14230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU57_RS14245	COG2223	nitrite transmembrane transporter activity
ISU57_RS14250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU57_RS14250	COG4651	solute:proton antiporter activity
ISU57_RS14255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_RS14260	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU57_RS14280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_RS14320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU57_RS14340	COG0543	2 iron, 2 sulfur cluster binding
ISU57_RS14340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU57_RS14370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU57_RS14380	COG2832	Protein of unknown function (DUF454)
ISU57_RS14395	COG1196	nuclear chromosome segregation
ISU57_RS14395	COG3264	Mechanosensitive ion channel
ISU57_RS14405	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU57_RS14410	COG1309	transcriptional regulator
ISU57_RS14415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_RS14420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_RS14430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU57_RS14455	COG3695	enzyme binding
ISU57_RS14460	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU57_RS14465	COG1946	Acyl-CoA thioesterase
ISU57_RS14470	COG0004	ammonium transporteR
ISU57_RS14475	COG0347	Belongs to the P(II) protein family
ISU57_RS14480	COG1132	(ABC) transporter
ISU57_RS14485	COG1132	(ABC) transporter
ISU57_RS14490	COG1522	sequence-specific DNA binding
ISU57_RS14505	COG4533	DNA binding
ISU57_RS14515	COG0824	Thioesterase
ISU57_RS14520	COG1555	photosystem II stabilization
ISU57_RS14525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU57_RS14530	COG0776	regulation of translation
ISU57_RS14535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU57_RS14555	COG0271	Belongs to the BolA IbaG family
ISU57_RS14560	COG3056	Lipoprotein
ISU57_RS14565	COG2223	nitrite transmembrane transporter activity
ISU57_RS14575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU57_RS14580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU57_RS14585	COG1845	cytochrome c oxidase, subunit III
ISU57_RS14590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU57_RS14600	COG2814	Major facilitator Superfamily
ISU57_RS14610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU57_RS14615	COG0693	protein deglycase activity
ISU57_RS14630	COG0142	geranyltranstransferase activity
ISU57_RS14655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU57_RS14660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU57_RS14675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU57_RS14675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU57_RS14700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU57_RS14705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU57_RS14710	COG1862	Preprotein translocase
ISU57_RS14730	COG0450	alkyl hydroperoxide reductase
ISU57_RS14750	COG0366	Alpha amylase catalytic
ISU57_RS14770	COG5002	protein histidine kinase activity
ISU57_RS14775	COG0745	RESPONSE REGULATOR receiver
ISU57_RS14780	COG0420	3'-5' exonuclease activity
ISU57_RS14785	COG0419	ATPase involved in DNA repair
ISU57_RS14790	COG1940	carbohydrate kinase activity
ISU57_RS14815	COG2226	methyltransferase
ISU57_RS14865	COG0583	DNA-binding transcription factor activity
ISU57_RS14870	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU57_RS14890	COG1477	protein flavinylation
ISU57_RS14910	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU57_RS14915	COG1805	sodium ion transport
ISU57_RS14925	COG3034	peptidoglycan biosynthetic process
ISU57_RS14930	COG0121	glutamine amidotransferase
ISU57_RS14940	COG1960	acyl-CoA dehydrogenase activity
ISU57_RS14950	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU57_RS14975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU57_RS14990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU57_RS15000	COG0765	amino acid transport
ISU57_RS15035	COG2814	Major facilitator Superfamily
ISU57_RS15040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU57_RS15050	COG1846	Transcriptional regulator
ISU57_RS15055	COG1566	PFAM secretion protein HlyD family protein
ISU57_RS15060	COG2814	Major facilitator Superfamily
ISU57_RS15065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU57_RS15070	COG3118	belongs to the thioredoxin family
ISU57_RS15075	COG3148	PFAM DTW domain containing protein
ISU57_RS15080	COG1042	CoA-binding domain protein
ISU57_RS15080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU57_RS15080	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU57_RS15085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU57_RS15090	COG5544	Lipoprotein
ISU57_RS15120	COG0542	response to heat
ISU57_RS15130	COG0564	pseudouridine synthase activity
ISU57_RS15135	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU57_RS15140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU57_RS15170	COG1605	Chorismate mutase
ISU57_RS15170	COG0287	Prephenate dehydrogenase
ISU57_RS15175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU57_RS15180	COG3279	Response regulator of the LytR AlgR family
ISU57_RS15190	COG3137	Salt-induced outer membrane protein
ISU57_RS15220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU57_RS15225	COG4137	Cytochrome C assembly protein
ISU57_RS15230	COG4536	flavin adenine dinucleotide binding
ISU57_RS15245	COG2918	glutathione biosynthetic process
ISU57_RS15250	COG1238	metal cluster binding
ISU57_RS15255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_RS15285	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU57_RS15325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU57_RS15330	COG3958	Transketolase
ISU57_RS15335	COG3959	Transketolase, thiamine diphosphate binding domain
ISU57_RS15340	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS15345	COG1129	ABC transporter
ISU57_RS15355	COG1879	ABC-type sugar transport system periplasmic component
ISU57_RS15365	COG3783	Cytochrome b(562)
ISU57_RS15370	COG3038	cytochrome b561
ISU57_RS15375	COG3381	protein complex oligomerization
ISU57_RS15380	COG3302	dmso reductase anchor subunit
ISU57_RS15385	COG0437	4 iron, 4 sulfur cluster binding
ISU57_RS15390	COG0243	molybdopterin cofactor binding
ISU57_RS15395	COG0235	Class ii aldolase
ISU57_RS15400	COG1349	DNA-binding transcription factor activity
ISU57_RS15415	COG1129	ABC transporter
ISU57_RS15420	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS15425	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS15430	COG3623	hexulose-6-phosphate isomerase
ISU57_RS15435	COG1070	Carbohydrate kinase
ISU57_RS15440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU57_RS15440	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU57_RS15450	COG0024	Methionine aminopeptidase
ISU57_RS15460	COG4771	TonB-dependent receptor
ISU57_RS15470	COG1858	cytochrome C peroxidase
ISU57_RS15475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS15495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU57_RS15510	COG2376	Dihydroxyacetone kinase
ISU57_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
ISU57_RS15520	COG1063	alcohol dehydrogenase
ISU57_RS15525	COG0698	ribose 5-phosphate isomerase
ISU57_RS15535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU57_RS15540	COG4942	peptidase
ISU57_RS15540	COG1388	LysM domain
ISU57_RS15580	COG0529	Catalyzes the synthesis of activated sulfate
ISU57_RS15635	COG0720	synthase
ISU57_RS15640	COG0602	queuosine metabolic process
ISU57_RS15660	COG3956	TIGRFAM MazG family protein
ISU57_RS15665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU57_RS15670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU57_RS15680	COG3850	Histidine kinase
ISU57_RS15680	COG4999	Histidine kinase
ISU57_RS15680	COG2205	protein histidine kinase activity
ISU57_RS15680	COG3437	response regulator, receiver
ISU57_RS15685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU57_RS15705	COG2860	membrane
ISU57_RS15725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS15730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU57_RS15735	COG1120	ATPase activity
ISU57_RS15740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU57_RS15745	COG1643	Atp-dependent helicase
ISU57_RS15750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU57_RS15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU57_RS15770	COG0617	tRNA 3'-terminal CCA addition
ISU57_RS15775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU57_RS15800	COG0842	Transport permease protein
ISU57_RS15805	COG1131	(ABC) transporter
ISU57_RS15810	COG0288	reversible hydration of carbon dioxide
ISU57_RS15815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU57_RS15820	COG2132	Multicopper oxidase
ISU57_RS15840	COG0697	spore germination
ISU57_RS15850	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU57_RS15860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU57_RS15865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU57_RS15870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU57_RS15875	COG2186	Transcriptional regulator
ISU57_RS15880	COG1113	amino acid transport
ISU57_RS15885	COG3725	Membrane protein required for beta-lactamase induction
ISU57_RS15890	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU57_RS15900	COG4969	Belongs to the N-Me-Phe pilin family
ISU57_RS15905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU57_RS15910	COG1459	type II secretion system
ISU57_RS15960	COG0582	viral genome integration into host DNA
ISU57_RS15970	COG0795	lipopolysaccharide-transporting ATPase activity
ISU57_RS15975	COG0795	lipopolysaccharide-transporting ATPase activity
ISU57_RS15985	COG2927	DNA polymerase III (CHI subunit)
ISU57_RS15990	COG0525	valine-tRNA ligase activity
ISU57_RS16000	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU57_RS16010	COG2731	YhcH YjgK YiaL family protein
ISU57_RS16020	COG0601	transmembrane transport
ISU57_RS16025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU57_RS16030	COG0444	Belongs to the ABC transporter superfamily
ISU57_RS16035	COG4608	Belongs to the ABC transporter superfamily
ISU57_RS16050	COG2188	Transcriptional regulator
ISU57_RS16055	COG3624	Phosphonate C-P lyase system protein PhnG
ISU57_RS16060	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU57_RS16065	COG3626	phosphonate metabolism
ISU57_RS16070	COG3627	carbon phosphorus lyase activity
ISU57_RS16075	COG4107	phosphonate C-P lyase system protein PhnK
ISU57_RS16080	COG4778	phosphonate C-P lyase system protein PhnL
ISU57_RS16085	COG3454	Phosphonate metabolism
ISU57_RS16090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU57_RS16095	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU57_RS16100	COG0702	epimerase
ISU57_RS16115	COG3842	ATPase activity
ISU57_RS16120	COG0395	ABC-type sugar transport system, permease component
ISU57_RS16125	COG1175	transmembrane transport
ISU57_RS16130	COG1653	transport
ISU57_RS16150	COG3153	acetyltransferase
ISU57_RS16155	COG3154	lipid carrier protein
ISU57_RS16160	COG0826	peptidase U32
ISU57_RS16165	COG0826	peptidase U32
ISU57_RS16175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_RS16185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU57_RS16205	COG0513	Belongs to the DEAD box helicase family
ISU57_RS16250	COG0195	Participates in both transcription termination and antitermination
ISU57_RS16270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU57_RS16280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU57_RS16295	COG1534	Rna-binding protein
ISU57_RS16305	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU57_RS16310	COG0745	RESPONSE REGULATOR receiver
ISU57_RS16315	COG0642	Histidine kinase
ISU57_RS16325	COG0697	spore germination
ISU57_RS16340	COG0142	geranyltranstransferase activity
ISU57_RS16350	COG3423	Transcriptional regulator
ISU57_RS16370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU57_RS16375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU57_RS16380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU57_RS16385	COG2105	PFAM AIG2 family protein
ISU57_RS16390	COG2911	Protein conserved in bacteria
ISU57_RS16395	COG0729	surface antigen
ISU57_RS16405	COG1253	flavin adenine dinucleotide binding
ISU57_RS16415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU57_RS16425	COG0737	Belongs to the 5'-nucleotidase family
ISU57_RS16435	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU57_RS16440	COG3061	Opacity-associated protein A
ISU57_RS16460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU57_RS16470	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU57_RS16475	COG1073	alpha beta
ISU57_RS16495	COG3650	response to hydrogen peroxide
ISU57_RS16500	COG1960	acyl-CoA dehydrogenase activity
ISU57_RS16505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU57_RS16510	COG0557	exoribonuclease II activity
ISU57_RS16525	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU57_RS16530	COG0330	HflC and HflK could
ISU57_RS16535	COG0330	HflC and HflK could
ISU57_RS16540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU57_RS16560	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU57_RS16565	COG0802	atpase or kinase
ISU57_RS16570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU57_RS16570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU57_RS16575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU57_RS16590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU57_RS16605	COG3264	Mechanosensitive ion channel
ISU57_RS16605	COG1511	domain protein
ISU57_RS16620	COG1053	succinate dehydrogenase
ISU57_RS16625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU57_RS16635	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU57_RS16680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISU57_RS16695	COG3383	formate dehydrogenase (NAD+) activity
ISU57_RS16700	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_RS16705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU57_RS16705	COG0493	'glutamate synthase
ISU57_RS16710	COG1309	transcriptional regulator
ISU57_RS16770	COG1454	alcohol dehydrogenase
ISU57_RS16780	COG0629	single-stranded DNA binding
ISU57_RS16785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU57_RS16790	COG2315	Protein conserved in bacteria
ISU57_RS16795	COG1448	Aminotransferase
ISU57_RS16820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU57_RS16825	COG0735	belongs to the Fur family
ISU57_RS16835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU57_RS16875	COG3121	Chaperone
ISU57_RS16935	COG1358	cellular component organization or biogenesis
ISU57_RS16960	COG3721	Heme iron utilization protein
ISU57_RS16965	COG0702	epimerase
ISU57_RS16975	COG4771	TonB-dependent receptor
ISU57_RS16980	COG3720	iron ion transport
ISU57_RS16985	COG4558	Periplasmic binding protein
ISU57_RS16990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU57_RS17000	COG0626	cystathionine gamma-synthase activity
ISU57_RS17005	COG0814	amino acid
ISU57_RS17010	COG0583	DNA-binding transcription factor activity
ISU57_RS17015	COG0425	Belongs to the sulfur carrier protein TusA family
ISU57_RS17020	COG2391	methyltransferase activity
ISU57_RS17130	COG1301	dicarboxylic acid transport
ISU57_RS17140	COG3162	membrane
ISU57_RS17200	COG0151	Belongs to the GarS family
ISU57_RS17220	COG1515	deoxyribonuclease V activity
ISU57_RS17255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU57_RS17310	COG0250	Participates in transcription elongation, termination and antitermination
ISU57_RS17370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU57_RS17400	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU57_RS17405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU57_RS17420	COG1739	Uncharacterized protein family UPF0029
ISU57_RS17445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU57_RS17480	COG0805	protein transport
ISU57_RS17490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU57_RS17510	COG1322	Protein conserved in bacteria
ISU57_RS17515	COG0586	Pfam SNARE associated Golgi protein
ISU57_RS17520	COG1966	Carbon starvation protein
ISU57_RS17535	COG0412	Dienelactone hydrolase
ISU57_RS17545	COG0583	DNA-binding transcription factor activity
ISU57_RS17550	COG0697	spore germination
ISU57_RS17555	COG0679	Auxin Efflux Carrier
ISU57_RS17560	COG0584	glycerophosphoryl diester phosphodiesterase
ISU57_RS17620	COG0410	ABC transporter
ISU57_RS17630	COG4177	L-phenylalanine transmembrane transporter activity
ISU57_RS17640	COG0683	leucine binding
ISU57_RS17660	COG2177	Part of the ABC transporter FtsEX involved in
ISU57_RS17665	COG2884	Cell division ATP-binding protein ftsE
ISU57_RS17670	COG0552	protein localization to endoplasmic reticulum
ISU57_RS17670	COG0552	protein localization to endoplasmic reticulum
ISU57_RS17675	COG0742	ribosomal rna small subunit methyltransferase
ISU57_RS17680	COG3776	membrane
ISU57_RS17695	COG3714	YhhN family
ISU57_RS17710	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU57_RS17720	COG0247	lactate metabolic process
ISU57_RS17730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU57_RS17735	COG0584	glycerophosphoryl diester phosphodiesterase
ISU57_RS17745	COG0561	phosphatase activity
ISU57_RS17750	COG2267	carboxylic ester hydrolase activity
ISU57_RS17755	COG1280	lysine exporter protein (LysE YggA)
ISU57_RS17760	COG1280	lysine exporter protein (LysE YggA)
ISU57_RS17765	COG0514	ATP-dependent DNA helicase (RecQ)
ISU57_RS17770	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU57_RS17775	COG2050	protein possibly involved in aromatic compounds catabolism
ISU57_RS17790	COG5564	TIM-barrel signal transduction protein
ISU57_RS17795	COG5441	Belongs to the UPF0261 family
ISU57_RS17805	COG0210	DNA helicase
ISU57_RS17810	COG1011	Hydrolase
ISU57_RS17815	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU57_RS17820	COG3159	Protein conserved in bacteria
ISU57_RS17840	COG3072	Adenylate cyclase
ISU57_RS17855	COG1587	Uroporphyrinogen-III synthase
ISU57_RS17860	COG2959	enzyme of heme biosynthesis
ISU57_RS17865	COG3071	HemY protein
ISU57_RS17895	COG1113	amino acid transport
ISU57_RS17915	COG2244	polysaccharide biosynthetic process
ISU57_RS17920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU57_RS17925	COG0456	acetyltransferase
ISU57_RS17930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU57_RS17935	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU57_RS17940	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU57_RS17945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU57_RS17950	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU57_RS17955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU57_RS17960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU57_RS17965	COG3118	belongs to the thioredoxin family
ISU57_RS17990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU57_RS18000	COG3328	transposase activity
ISU57_RS18010	COG3121	Chaperone
ISU57_RS18025	COG3121	Chaperone
ISU57_RS18060	COG0583	DNA-binding transcription factor activity
ISU57_RS18105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU57_RS18110	COG3978	acetolactate synthase activity
ISU57_RS18130	COG3085	chromosome segregation
ISU57_RS18140	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS18145	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS18150	COG1129	ABC transporter
ISU57_RS18155	COG1879	ABC-type sugar transport system periplasmic component
ISU57_RS18225	COG0678	peroxiredoxin activity
ISU57_RS18225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU57_RS18230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU57_RS18255	COG1629	transport
ISU57_RS18270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU57_RS18295	COG0527	aspartate kinase activity
ISU57_RS18295	COG0460	homoserine dehydrogenase
ISU57_RS18310	COG4682	membrane
ISU57_RS18320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU57_RS18325	COG1609	Transcriptional regulator
ISU57_RS18330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU57_RS18345	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU57_RS18455	COG3501	Rhs element vgr protein
ISU57_RS18500	COG3501	Rhs element vgr protein
ISU57_RS18510	COG3209	COG3209 Rhs family protein
ISU57_RS18530	COG0673	inositol 2-dehydrogenase activity
ISU57_RS18535	COG1917	Cupin 2, conserved barrel domain protein
ISU57_RS18535	COG2207	Transcriptional regulator
ISU57_RS18540	COG1869	D-ribose catabolic process
ISU57_RS18545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_RS18550	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU57_RS18555	COG0431	NADPH-dependent FMN reductase
ISU57_RS18560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU57_RS18570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU57_RS18585	COG3077	Addiction module antitoxin, RelB DinJ family
ISU57_RS18590	COG2252	PERMEase
ISU57_RS18595	COG0025	NhaP-type Na H and K H
ISU57_RS18605	COG1560	Kdo2-lipid A biosynthetic process
ISU57_RS18615	COG1129	ABC transporter
ISU57_RS18620	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU57_RS18630	COG1069	ribulokinase activity
ISU57_RS18640	COG0625	glutathione transferase activity
ISU57_RS18660	COG1278	Cold shock
ISU57_RS18665	COG1278	Cold shock
ISU57_RS18670	COG3133	Outer membrane lipoprotein
ISU57_RS18675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU57_RS18685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU57_RS18715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU57_RS18720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU57_RS18730	COG4145	pantothenate transmembrane transporter activity
ISU57_RS18735	COG3924	membrane
ISU57_RS18745	COG0439	Biotin carboxylase
ISU57_RS18750	COG0511	ligase activity, forming carbon-carbon bonds
ISU57_RS18765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU57_RS18770	COG0604	alcohol dehydrogenase
ISU57_RS18775	COG2200	EAL domain
ISU57_RS18775	COG2199	diguanylate cyclase activity
ISU57_RS18780	COG1077	Cell shape determining protein MreB Mrl
ISU57_RS18785	COG1792	Involved in formation and maintenance of cell shape
ISU57_RS18790	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU57_RS18795	COG0424	maF-like protein
ISU57_RS18800	COG1530	ribonuclease E activity
ISU57_RS18805	COG3164	Protein of unknown function
ISU57_RS18810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU57_RS18815	COG0312	modulator of DNA gyrase
ISU57_RS18865	COG0583	DNA-binding transcription factor activity
ISU57_RS18895	COG2732	(Barnase) inhibitor
ISU57_RS18905	COG0312	modulator of DNA gyrase
ISU57_RS18915	COG3783	Cytochrome b(562)
ISU57_RS18920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU57_RS18925	COG0366	Alpha amylase catalytic
ISU57_RS18930	COG1263	PTS System
ISU57_RS18930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU57_RS18935	COG1609	Transcriptional regulator
ISU57_RS18960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS18980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU57_RS18985	COG1137	ATPase activity
ISU57_RS18990	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU57_RS18995	COG3117	lipopolysaccharide transmembrane transporter activity
ISU57_RS19000	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU57_RS19005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU57_RS19005	COG0517	IMP dehydrogenase activity
ISU57_RS19015	COG1127	ABC transporter
ISU57_RS19020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU57_RS19025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU57_RS19030	COG2854	intermembrane phospholipid transfer
ISU57_RS19035	COG3113	response to antibiotic
ISU57_RS19040	COG5007	Belongs to the BolA IbaG family
ISU57_RS19050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU57_RS19060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU57_RS19065	COG3105	Protein conserved in bacteria
ISU57_RS19070	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU57_RS19090	COG0625	glutathione transferase activity
ISU57_RS19095	COG2969	positive regulation of protein catabolic process
ISU57_RS19105	COG0493	'glutamate synthase
ISU57_RS19110	COG0070	glutamate synthase
ISU57_RS19110	COG0067	glutamate synthase
ISU57_RS19110	COG0069	glutamate synthase activity
ISU57_RS19120	COG0784	Response regulator, receiver
ISU57_RS19120	COG5002	protein histidine kinase activity
ISU57_RS19120	COG2198	Histidine kinase
ISU57_RS19125	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU57_RS19135	COG2823	Periplasmic or secreted lipoprotein
ISU57_RS19155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU57_RS19165	COG1741	Belongs to the pirin family
ISU57_RS19170	COG0583	DNA-binding transcription factor activity
ISU57_RS19190	COG0456	acetyltransferase
ISU57_RS19195	COG2982	Protein involved in outer membrane biogenesis
ISU57_RS19200	COG2233	PERMEase
ISU57_RS19205	COG0786	glutamate:sodium symporter activity
ISU57_RS19215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU57_RS19220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU57_RS19225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU57_RS19245	COG2860	membrane
ISU57_RS19250	COG1561	YicC-like family, N-terminal region
ISU57_RS19275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU57_RS19310	COG1519	Transferase
ISU57_RS19315	COG0859	PFAM glycosyl transferase family 9
ISU57_RS19320	COG0859	PFAM glycosyl transferase family 9
ISU57_RS19330	COG0156	8-amino-7-oxononanoate synthase activity
ISU57_RS19345	COG4942	peptidase
ISU57_RS19355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU57_RS19360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU57_RS19375	COG1045	serine acetyltransferase
ISU57_RS19380	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU57_RS19385	COG2169	Transcriptional regulator
ISU57_RS19385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU57_RS19390	COG2205	protein histidine kinase activity
ISU57_RS19395	COG0745	RESPONSE REGULATOR receiver
ISU57_RS19400	COG3678	ATP-independent chaperone mediated protein folding
ISU57_RS19425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU57_RS19435	COG0471	metal ion transport
ISU57_RS19440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU57_RS19445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU57_RS19450	COG0583	DNA-binding transcription factor activity
ISU57_RS19465	COG3152	Membrane
ISU57_RS19475	COG1494	fructose-1,6-bisphosphatase
ISU57_RS19480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU57_RS19485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU57_RS19530	COG0560	Phosphoserine phosphatase
ISU57_RS19535	COG3726	membrane protein affecting hemolysin expression
ISU57_RS19565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU57_RS19570	COG0084	hydrolase, TatD family'
ISU57_RS19575	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU57_RS19585	COG2823	Periplasmic or secreted lipoprotein
ISU57_RS19595	COG0456	acetyltransferase
ISU57_RS19600	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU57_RS19640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU57_RS19645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU57_RS19660	COG0859	PFAM glycosyl transferase family 9
ISU57_RS19665	COG1070	Carbohydrate kinase
ISU57_RS19715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS19715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU57_RS19715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU57_RS19720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_RS19725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_RS19730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU57_RS19735	COG2207	Transcriptional regulator
ISU57_RS19745	COG4269	membrane
ISU57_RS19800	COG1401	restriction endodeoxyribonuclease activity
ISU57_RS19825	COG1011	Hydrolase
ISU57_RS19835	COG0174	glutamine synthetase
ISU57_RS19840	COG3852	Histidine kinase
ISU57_RS19850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU57_RS19875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU57_RS19875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU57_RS19880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU57_RS19885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU57_RS19890	COG3084	Protein conserved in bacteria
ISU57_RS19900	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU57_RS19905	COG3328	transposase activity
ISU57_RS19930	COG2186	Transcriptional regulator
ISU57_RS19935	COG0477	Major facilitator Superfamily
ISU57_RS19950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU57_RS19980	COG1522	sequence-specific DNA binding
ISU57_RS19985	COG0716	FMN binding
ISU57_RS20000	COG3312	ion transport
ISU57_RS20055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU57_RS20060	COG0573	inorganic phosphate transmembrane transporter activity
ISU57_RS20065	COG0581	inorganic phosphate transmembrane transporter activity
ISU57_RS20075	COG0704	Plays a role in the regulation of phosphate uptake
ISU57_RS20085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU57_RS20090	COG0765	amino acid transport
ISU57_RS20095	COG0765	amino acid transport
ISU57_RS20100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU57_RS20110	COG2252	PERMEase
ISU57_RS20140	COG0706	membrane insertase activity
ISU57_RS20155	COG0230	Belongs to the bacterial ribosomal protein bL34 family