locus-tag	class	description
ISU58_RS00010	COG0592	DNA-directed DNA polymerase activity
ISU58_RS00025	COG0187	DNA topoisomerase II activity
ISU58_RS00030	COG0561	phosphatase activity
ISU58_RS00055	COG1349	DNA-binding transcription factor activity
ISU58_RS00075	COG0058	SHG alpha-glucan phosphorylase activity
ISU58_RS00080	COG0058	SHG alpha-glucan phosphorylase activity
ISU58_RS00085	COG1640	4-alpha-glucanotransferase
ISU58_RS00120	COG1918	ferrous iron import across plasma membrane
ISU58_RS00125	COG2183	response to ionizing radiation
ISU58_RS00130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU58_RS00155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU58_RS00160	COG1011	Hydrolase
ISU58_RS00170	COG0494	nUDIX hydrolase
ISU58_RS00175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU58_RS00200	COG4796	Type ii and iii secretion system protein
ISU58_RS00225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU58_RS00230	COG0546	phosphoglycolate phosphatase activity
ISU58_RS00235	COG0180	Tryptophanyl-tRNA synthetase
ISU58_RS00255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU58_RS00260	COG0402	S-adenosylhomocysteine deaminase activity
ISU58_RS00280	COG1486	melibiose metabolic process
ISU58_RS00285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU58_RS00290	COG0433	COG0433 Predicted ATPase
ISU58_RS00305	COG1289	transmembrane transporter activity
ISU58_RS00315	COG1765	OsmC-like protein
ISU58_RS00325	COG3954	Phosphoribulokinase
ISU58_RS00335	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU58_RS00345	COG4521	taurine ABC transporter
ISU58_RS00355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU58_RS00360	COG2175	clavaminate synthase activity
ISU58_RS00370	COG1216	Glycosyl transferase, family 2
ISU58_RS00390	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU58_RS00395	COG1047	Peptidyl-prolyl cis-trans
ISU58_RS00405	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU58_RS00410	COG2964	Protein conserved in bacteria
ISU58_RS00430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU58_RS00435	COG0049	tRNA binding
ISU58_RS00465	COG0051	transcription antitermination factor activity, RNA binding
ISU58_RS00480	COG0089	rRNA binding
ISU58_RS00490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU58_RS00500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU58_RS00505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU58_RS00515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU58_RS00520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU58_RS00560	COG1841	ribosomal large subunit assembly
ISU58_RS00570	COG0201	protein transport
ISU58_RS00575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU58_RS00590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU58_RS00605	COG0789	Transcriptional regulator
ISU58_RS00610	COG3036	rescue of stalled ribosome
ISU58_RS00640	COG0758	DNA mediated transformation
ISU58_RS00650	COG0551	DNA topoisomerase type I activity
ISU58_RS00665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU58_RS00685	COG2197	response regulator
ISU58_RS00690	COG2194	sulfuric ester hydrolase activity
ISU58_RS00705	COG2986	histidine ammonia-lyase
ISU58_RS00735	COG4607	ABC-type enterochelin transport system periplasmic component
ISU58_RS00745	COG4605	iron ion homeostasis
ISU58_RS00750	COG4604	ABC transporter, ATP-binding protein
ISU58_RS00795	COG0582	viral genome integration into host DNA
ISU58_RS00805	COG1609	Transcriptional regulator
ISU58_RS00805	COG2207	Transcriptional regulator
ISU58_RS00810	COG4214	carbohydrate transport
ISU58_RS00820	COG4213	ABC transporter substrate-binding protein
ISU58_RS00830	COG1070	Carbohydrate kinase
ISU58_RS00840	COG3121	Chaperone
ISU58_RS00855	COG3274	enterobacterial common antigen metabolic process
ISU58_RS00900	COG3276	selenocysteine insertion sequence binding
ISU58_RS00915	COG2864	formate dehydrogenase
ISU58_RS00920	COG0437	4 iron, 4 sulfur cluster binding
ISU58_RS00935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU58_RS00960	COG3722	fumarate hydratase activity
ISU58_RS00970	COG2213	PTS system mannitol-specific
ISU58_RS00970	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_RS00995	COG2818	Glycosylase
ISU58_RS01005	COG2885	chlorophyll binding
ISU58_RS01020	COG0366	Alpha amylase catalytic
ISU58_RS01030	COG3977	Valine--pyruvate aminotransferase
ISU58_RS01050	COG5645	(Lipo)protein
ISU58_RS01060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU58_RS01065	COG2423	ornithine cyclodeaminase activity
ISU58_RS01090	COG0513	Belongs to the DEAD box helicase family
ISU58_RS01110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU58_RS01120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_RS01130	COG0826	peptidase U32
ISU58_RS01135	COG0826	peptidase U32
ISU58_RS01140	COG3154	lipid carrier protein
ISU58_RS01145	COG3153	acetyltransferase
ISU58_RS01165	COG1653	transport
ISU58_RS01170	COG1175	transmembrane transport
ISU58_RS01175	COG0395	ABC-type sugar transport system, permease component
ISU58_RS01180	COG3842	ATPase activity
ISU58_RS01195	COG0702	epimerase
ISU58_RS01200	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU58_RS01205	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU58_RS01210	COG3454	Phosphonate metabolism
ISU58_RS01215	COG4778	phosphonate C-P lyase system protein PhnL
ISU58_RS01220	COG4107	phosphonate C-P lyase system protein PhnK
ISU58_RS01225	COG3627	carbon phosphorus lyase activity
ISU58_RS01230	COG3626	phosphonate metabolism
ISU58_RS01235	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU58_RS01240	COG3624	Phosphonate C-P lyase system protein PhnG
ISU58_RS01245	COG2188	Transcriptional regulator
ISU58_RS01260	COG4608	Belongs to the ABC transporter superfamily
ISU58_RS01265	COG0444	Belongs to the ABC transporter superfamily
ISU58_RS01270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_RS01275	COG0601	transmembrane transport
ISU58_RS01285	COG2731	YhcH YjgK YiaL family protein
ISU58_RS01295	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU58_RS01305	COG0525	valine-tRNA ligase activity
ISU58_RS01310	COG2927	DNA polymerase III (CHI subunit)
ISU58_RS01320	COG0795	lipopolysaccharide-transporting ATPase activity
ISU58_RS01325	COG0795	lipopolysaccharide-transporting ATPase activity
ISU58_RS01335	COG0582	viral genome integration into host DNA
ISU58_RS01385	COG1459	type II secretion system
ISU58_RS01390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU58_RS01395	COG4969	Belongs to the N-Me-Phe pilin family
ISU58_RS01405	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU58_RS01410	COG3725	Membrane protein required for beta-lactamase induction
ISU58_RS01415	COG1113	amino acid transport
ISU58_RS01420	COG2186	Transcriptional regulator
ISU58_RS01425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU58_RS01430	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU58_RS01435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU58_RS01445	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU58_RS01455	COG0697	spore germination
ISU58_RS01475	COG2132	Multicopper oxidase
ISU58_RS01480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU58_RS01485	COG0288	reversible hydration of carbon dioxide
ISU58_RS01490	COG1131	(ABC) transporter
ISU58_RS01495	COG0842	Transport permease protein
ISU58_RS01520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU58_RS01525	COG0617	tRNA 3'-terminal CCA addition
ISU58_RS01530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU58_RS01545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU58_RS01550	COG1643	Atp-dependent helicase
ISU58_RS01555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU58_RS01560	COG1120	ATPase activity
ISU58_RS01565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU58_RS01570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS01590	COG2860	membrane
ISU58_RS01610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU58_RS01615	COG3437	response regulator, receiver
ISU58_RS01615	COG2205	protein histidine kinase activity
ISU58_RS01615	COG4999	Histidine kinase
ISU58_RS01615	COG3850	Histidine kinase
ISU58_RS01625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU58_RS01630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU58_RS01635	COG3956	TIGRFAM MazG family protein
ISU58_RS01655	COG0602	queuosine metabolic process
ISU58_RS01660	COG0720	synthase
ISU58_RS01715	COG0529	Catalyzes the synthesis of activated sulfate
ISU58_RS01755	COG4942	peptidase
ISU58_RS01755	COG1388	LysM domain
ISU58_RS01770	COG0698	ribose 5-phosphate isomerase
ISU58_RS01775	COG1063	alcohol dehydrogenase
ISU58_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS01785	COG2376	Dihydroxyacetone kinase
ISU58_RS01800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU58_RS01820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS01825	COG1858	cytochrome C peroxidase
ISU58_RS01835	COG4771	TonB-dependent receptor
ISU58_RS01845	COG0024	Methionine aminopeptidase
ISU58_RS01855	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU58_RS01855	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU58_RS01860	COG1070	Carbohydrate kinase
ISU58_RS01865	COG3623	hexulose-6-phosphate isomerase
ISU58_RS01870	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS01875	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS01880	COG1129	ABC transporter
ISU58_RS01895	COG1349	DNA-binding transcription factor activity
ISU58_RS01900	COG0235	Class ii aldolase
ISU58_RS01905	COG0243	molybdopterin cofactor binding
ISU58_RS01910	COG0437	4 iron, 4 sulfur cluster binding
ISU58_RS01915	COG3302	dmso reductase anchor subunit
ISU58_RS01920	COG3381	protein complex oligomerization
ISU58_RS01925	COG3038	cytochrome b561
ISU58_RS01930	COG3783	Cytochrome b(562)
ISU58_RS01940	COG1879	ABC-type sugar transport system periplasmic component
ISU58_RS01950	COG1129	ABC transporter
ISU58_RS01955	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS01960	COG3959	Transketolase, thiamine diphosphate binding domain
ISU58_RS01965	COG3958	Transketolase
ISU58_RS01970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU58_RS02010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU58_RS02040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_RS02045	COG1238	metal cluster binding
ISU58_RS02050	COG2918	glutathione biosynthetic process
ISU58_RS02065	COG4536	flavin adenine dinucleotide binding
ISU58_RS02070	COG4137	Cytochrome C assembly protein
ISU58_RS02075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU58_RS02105	COG3137	Salt-induced outer membrane protein
ISU58_RS02115	COG3279	Response regulator of the LytR AlgR family
ISU58_RS02120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU58_RS02125	COG0287	Prephenate dehydrogenase
ISU58_RS02125	COG1605	Chorismate mutase
ISU58_RS02155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU58_RS02160	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU58_RS02165	COG0564	pseudouridine synthase activity
ISU58_RS02175	COG0542	response to heat
ISU58_RS02205	COG5544	Lipoprotein
ISU58_RS02210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU58_RS02215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU58_RS02215	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU58_RS02215	COG1042	CoA-binding domain protein
ISU58_RS02220	COG3148	PFAM DTW domain containing protein
ISU58_RS02225	COG3118	belongs to the thioredoxin family
ISU58_RS02230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU58_RS02235	COG2814	Major facilitator Superfamily
ISU58_RS02240	COG1566	PFAM secretion protein HlyD family protein
ISU58_RS02245	COG1846	Transcriptional regulator
ISU58_RS02255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU58_RS02260	COG2814	Major facilitator Superfamily
ISU58_RS02295	COG0765	amino acid transport
ISU58_RS02305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU58_RS02320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU58_RS02345	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU58_RS02355	COG1960	acyl-CoA dehydrogenase activity
ISU58_RS02365	COG0121	glutamine amidotransferase
ISU58_RS02370	COG3034	peptidoglycan biosynthetic process
ISU58_RS02380	COG1805	sodium ion transport
ISU58_RS02385	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU58_RS02405	COG1477	protein flavinylation
ISU58_RS02425	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU58_RS02430	COG0583	DNA-binding transcription factor activity
ISU58_RS02480	COG2226	methyltransferase
ISU58_RS02505	COG1940	carbohydrate kinase activity
ISU58_RS02510	COG0419	ATPase involved in DNA repair
ISU58_RS02515	COG0420	3'-5' exonuclease activity
ISU58_RS02520	COG0745	RESPONSE REGULATOR receiver
ISU58_RS02525	COG5002	protein histidine kinase activity
ISU58_RS02545	COG0366	Alpha amylase catalytic
ISU58_RS02565	COG0450	alkyl hydroperoxide reductase
ISU58_RS02585	COG1862	Preprotein translocase
ISU58_RS02590	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU58_RS02595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU58_RS02625	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU58_RS02625	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU58_RS02640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU58_RS02645	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU58_RS02660	COG0142	geranyltranstransferase activity
ISU58_RS02675	COG0693	protein deglycase activity
ISU58_RS02680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU58_RS02690	COG2814	Major facilitator Superfamily
ISU58_RS02700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU58_RS02705	COG1845	cytochrome c oxidase, subunit III
ISU58_RS02710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU58_RS02715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU58_RS02725	COG2223	nitrite transmembrane transporter activity
ISU58_RS02730	COG3056	Lipoprotein
ISU58_RS02735	COG0271	Belongs to the BolA IbaG family
ISU58_RS02755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU58_RS02760	COG0776	regulation of translation
ISU58_RS02765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU58_RS02770	COG1555	photosystem II stabilization
ISU58_RS02775	COG0824	Thioesterase
ISU58_RS02810	COG1522	sequence-specific DNA binding
ISU58_RS02815	COG1132	(ABC) transporter
ISU58_RS02820	COG1132	(ABC) transporter
ISU58_RS02825	COG0347	Belongs to the P(II) protein family
ISU58_RS02830	COG0004	ammonium transporteR
ISU58_RS02835	COG1946	Acyl-CoA thioesterase
ISU58_RS02840	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU58_RS02845	COG3695	enzyme binding
ISU58_RS02870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU58_RS02880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_RS02885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_RS02890	COG1309	transcriptional regulator
ISU58_RS02895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU58_RS02900	COG1196	nuclear chromosome segregation
ISU58_RS02900	COG3264	Mechanosensitive ion channel
ISU58_RS02915	COG2832	Protein of unknown function (DUF454)
ISU58_RS02925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU58_RS02955	COG0543	2 iron, 2 sulfur cluster binding
ISU58_RS02955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_RS02975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_RS03015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_RS03035	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU58_RS03040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_RS03045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU58_RS03045	COG4651	solute:proton antiporter activity
ISU58_RS03050	COG2223	nitrite transmembrane transporter activity
ISU58_RS03065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU58_RS03070	COG3735	TraB family
ISU58_RS03075	COG2217	Heavy metal translocating P-type atpase
ISU58_RS03080	COG0789	Transcriptional regulator
ISU58_RS03085	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU58_RS03090	COG0330	HflC and HflK could
ISU58_RS03095	COG3118	belongs to the thioredoxin family
ISU58_RS03100	COG0300	oxidoreductase activity
ISU58_RS03105	COG2755	lipolytic protein G-D-S-L family
ISU58_RS03110	COG4181	ATPase activity
ISU58_RS03115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU58_RS03120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU58_RS03125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU58_RS03135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU58_RS03150	COG2501	S4 domain
ISU58_RS03185	COG0582	viral genome integration into host DNA
ISU58_RS03195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU58_RS03200	COG4589	Belongs to the CDS family
ISU58_RS03210	COG2267	carboxylic ester hydrolase activity
ISU58_RS03215	COG0671	phosphoesterase, PA-phosphatase related
ISU58_RS03215	COG2453	phosphatase
ISU58_RS03245	COG0667	Aldo Keto reductase
ISU58_RS03250	COG0656	L-ascorbic acid biosynthetic process
ISU58_RS03260	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU58_RS03275	COG3328	transposase activity
ISU58_RS03330	COG3423	Transcriptional regulator
ISU58_RS03335	COG4953	penicillin-binding protein 1C
ISU58_RS03345	COG2373	Large extracellular alpha-helical protein
ISU58_RS03365	COG3962	Belongs to the TPP enzyme family
ISU58_RS03380	COG1129	ABC transporter
ISU58_RS03385	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS03390	COG0673	inositol 2-dehydrogenase activity
ISU58_RS03395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_RS03405	COG3718	enzyme involved in inositol metabolism
ISU58_RS03415	COG5265	(ABC) transporter
ISU58_RS03440	COG2197	response regulator
ISU58_RS03445	COG1278	Cold shock
ISU58_RS03455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU58_RS03460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU58_RS03480	COG1686	Belongs to the peptidase S11 family
ISU58_RS03485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU58_RS03490	COG0772	Belongs to the SEDS family
ISU58_RS03495	COG0768	penicillin binding
ISU58_RS03505	COG0799	negative regulation of ribosome biogenesis
ISU58_RS03515	COG1466	dna polymerase III delta subunit
ISU58_RS03530	COG2888	peptidyl-tyrosine sulfation
ISU58_RS03535	COG1126	abc transporter atp-binding protein
ISU58_RS03540	COG0765	amino acid transport
ISU58_RS03545	COG0765	amino acid transport
ISU58_RS03555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU58_RS03560	COG4535	Mg2 and Co2 transporter CorC
ISU58_RS03570	COG1702	phosphate starvation-inducible protein PhoH
ISU58_RS03575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU58_RS03580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU58_RS03615	COG0367	asparagine synthase
ISU58_RS03620	COG0647	UMP catabolic process
ISU58_RS03625	COG1846	Transcriptional regulator
ISU58_RS03625	COG1940	carbohydrate kinase activity
ISU58_RS03630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU58_RS03640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_RS03640	COG1263	PTS System
ISU58_RS03640	COG2190	(PTS) system
ISU58_RS03665	COG0735	belongs to the Fur family
ISU58_RS03680	COG0596	Alpha beta hydrolase
ISU58_RS03690	COG0582	viral genome integration into host DNA
ISU58_RS03725	COG2113	Glycine betaine
ISU58_RS03730	COG4176	ABC-type proline glycine betaine transport system permease component
ISU58_RS03735	COG4175	Glycine betaine
ISU58_RS03740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU58_RS03780	COG1278	Cold shock
ISU58_RS03785	COG0747	negative chemotaxis
ISU58_RS03795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_RS03800	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU58_RS03805	COG1124	(ABC) transporter
ISU58_RS03810	COG0831	urea catabolic process
ISU58_RS03835	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU58_RS03845	COG4413	Urea transporter
ISU58_RS03850	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU58_RS03860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU58_RS03870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU58_RS03880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU58_RS03885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU58_RS03890	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU58_RS03895	COG2169	Transcriptional regulator
ISU58_RS03895	COG1917	Cupin 2, conserved barrel domain protein
ISU58_RS03910	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU58_RS03915	COG0033	Phosphoglucomutase
ISU58_RS03930	COG0745	RESPONSE REGULATOR receiver
ISU58_RS03935	COG2205	protein histidine kinase activity
ISU58_RS03970	COG3272	Protein of unknown function (DUF1722)
ISU58_RS03980	COG5212	phosphodiesterase
ISU58_RS03985	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU58_RS04000	COG1984	allophanate hydrolase subunit 2
ISU58_RS04045	COG0513	Belongs to the DEAD box helicase family
ISU58_RS04055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU58_RS04070	COG3026	antisigma factor binding
ISU58_RS04075	COG3086	response to oxidative stress
ISU58_RS04110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU58_RS04125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_RS04130	COG1737	Transcriptional regulator
ISU58_RS04140	COG0560	Phosphoserine phosphatase
ISU58_RS04185	COG2205	protein histidine kinase activity
ISU58_RS04190	COG3170	Tfp pilus assembly protein FimV
ISU58_RS04195	COG2204	response regulator
ISU58_RS04200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU58_RS04200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU58_RS04205	COG0347	Belongs to the P(II) protein family
ISU58_RS04230	COG1017	nitric oxide dioxygenase activity
ISU58_RS04230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_RS04250	COG2814	Major facilitator Superfamily
ISU58_RS04255	COG3711	transcriptional antiterminator
ISU58_RS04260	COG3683	transport system, periplasmic component
ISU58_RS04265	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU58_RS04285	COG1104	cysteine desulfurase activity
ISU58_RS04290	COG0822	iron-sulfur transferase activity
ISU58_RS04310	COG0633	Ferredoxin
ISU58_RS04315	COG2975	iron-sulfur cluster assembly
ISU58_RS04340	COG3468	outer membrane autotransporter barrel domain protein
ISU58_RS04345	COG3468	outer membrane autotransporter barrel domain protein
ISU58_RS04385	COG2976	Protein conserved in bacteria
ISU58_RS04390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU58_RS04405	COG1645	bacterial-type flagellum-dependent swarming motility
ISU58_RS04415	COG0517	IMP dehydrogenase activity
ISU58_RS04415	COG0516	GMP reductase activity
ISU58_RS04460	COG3328	transposase activity
ISU58_RS04475	COG0351	phosphomethylpyrimidine kinase
ISU58_RS04500	COG0826	peptidase U32
ISU58_RS04505	COG3422	double-strand break repair
ISU58_RS04510	COG0745	RESPONSE REGULATOR receiver
ISU58_RS04540	COG3842	ATPase activity
ISU58_RS04550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU58_RS04560	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU58_RS04565	COG1177	transmembrane transport
ISU58_RS04570	COG0443	Heat shock 70 kDa protein
ISU58_RS04575	COG2239	Acts as a magnesium transporter
ISU58_RS04590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU58_RS04600	COG0581	inorganic phosphate transmembrane transporter activity
ISU58_RS04615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU58_RS04620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU58_RS04645	COG1393	Belongs to the ArsC family
ISU58_RS04650	COG4783	chaperone-mediated protein folding
ISU58_RS04655	COG0628	permease
ISU58_RS04665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU58_RS04670	COG2716	regulation of RNA biosynthetic process
ISU58_RS04680	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU58_RS04695	COG2321	neutral zinc metallopeptidase
ISU58_RS04715	COG1876	peptidase activity
ISU58_RS04725	COG1393	Belongs to the ArsC family
ISU58_RS04740	COG1175	transmembrane transport
ISU58_RS04745	COG3842	ATPase activity
ISU58_RS04755	COG3119	arylsulfatase activity
ISU58_RS04760	COG0641	radical SAM
ISU58_RS04765	COG1988	membrane-bound metal-dependent
ISU58_RS04775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_RS04785	COG2197	response regulator
ISU58_RS04790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_RS04790	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_RS04795	COG3062	negative regulation of establishment of protein localization
ISU58_RS04805	COG3043	anaerobic respiration
ISU58_RS04810	COG3005	denitrification pathway
ISU58_RS04860	COG2837	iron assimilation
ISU58_RS04865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU58_RS04875	COG4886	Leucine-rich repeat (LRR) protein
ISU58_RS04885	COG2731	YhcH YjgK YiaL family protein
ISU58_RS04890	COG1737	Transcriptional regulator
ISU58_RS04900	COG4150	thiosulfate binding
ISU58_RS04905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU58_RS04910	COG4208	sulfate ABC transporter
ISU58_RS04915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU58_RS04930	COG0745	RESPONSE REGULATOR receiver
ISU58_RS04935	COG5002	protein histidine kinase activity
ISU58_RS04935	COG3850	Histidine kinase
ISU58_RS04945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU58_RS04965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU58_RS04980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_RS04985	COG0745	RESPONSE REGULATOR receiver
ISU58_RS04990	COG2205	protein histidine kinase activity
ISU58_RS05010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_RS05020	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU58_RS05035	COG3530	Putative quorum-sensing-regulated virulence factor
ISU58_RS05100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU58_RS05115	COG0667	Aldo Keto reductase
ISU58_RS05140	COG0436	Aminotransferase
ISU58_RS05145	COG3038	cytochrome b561
ISU58_RS05175	COG3381	protein complex oligomerization
ISU58_RS05180	COG3302	dmso reductase anchor subunit
ISU58_RS05185	COG0437	4 iron, 4 sulfur cluster binding
ISU58_RS05190	COG0243	molybdopterin cofactor binding
ISU58_RS05225	COG2951	lytic endotransglycosylase activity
ISU58_RS05285	COG3121	Chaperone
ISU58_RS05290	COG3188	usher protein
ISU58_RS05295	COG3328	transposase activity
ISU58_RS05300	COG3188	usher protein
ISU58_RS05390	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU58_RS05400	COG1704	LemA family
ISU58_RS05420	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU58_RS05425	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU58_RS05430	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU58_RS05440	COG1138	Cytochrome C-type biogenesis protein
ISU58_RS05450	COG4235	cytochrome complex assembly
ISU58_RS05450	COG3088	subunit of a heme lyase
ISU58_RS05455	COG4235	cytochrome complex assembly
ISU58_RS05455	COG3088	subunit of a heme lyase
ISU58_RS05470	COG3691	Protein conserved in bacteria
ISU58_RS05485	COG2062	phosphohistidine phosphatase, SixA
ISU58_RS05495	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU58_RS05510	COG0730	response to heat
ISU58_RS05515	COG3101	peptidyl-lysine hydroxylation
ISU58_RS05530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU58_RS05535	COG1794	racemase activity, acting on amino acids and derivatives
ISU58_RS05550	COG0697	spore germination
ISU58_RS05565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU58_RS05575	COG0586	Pfam SNARE associated Golgi protein
ISU58_RS05585	COG0285	dihydrofolate synthase activity
ISU58_RS05590	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU58_RS05595	COG1286	toxin biosynthetic process
ISU58_RS05600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU58_RS05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS05615	COG4215	(ABC) transporter
ISU58_RS05620	COG4160	amino acid transport
ISU58_RS05625	COG4598	ABC transporter
ISU58_RS05630	COG1090	epimerase
ISU58_RS05640	COG0622	Phosphoesterase
ISU58_RS05645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU58_RS05650	COG3037	sugar-specific permease SgaT UlaA
ISU58_RS05655	COG3328	transposase activity
ISU58_RS05670	COG1609	Transcriptional regulator
ISU58_RS05675	COG0857	belongs to the CobB CobQ family
ISU58_RS05675	COG0280	phosphate acetyltransferase
ISU58_RS05695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_RS05700	COG0490	domain, Protein
ISU58_RS05700	COG0471	metal ion transport
ISU58_RS05715	COG0436	Aminotransferase
ISU58_RS05720	COG0583	DNA-binding transcription factor activity
ISU58_RS05730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU58_RS05750	COG1034	ATP synthesis coupled electron transport
ISU58_RS05765	COG0839	Belongs to the complex I subunit 6 family
ISU58_RS05775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU58_RS05780	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU58_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS05805	COG3265	gluconokinase activity
ISU58_RS05820	COG1649	PFAM Uncharacterised BCR, COG1649
ISU58_RS05825	COG1609	Transcriptional regulator
ISU58_RS05830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU58_RS05845	COG0129	dihydroxy-acid dehydratase activity
ISU58_RS05850	COG4575	ribosome binding
ISU58_RS05860	COG1169	isochorismate synthase
ISU58_RS05875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU58_RS05890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU58_RS05925	COG1126	abc transporter atp-binding protein
ISU58_RS05930	COG0765	amino acid transport
ISU58_RS05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS05965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU58_RS05985	COG1063	alcohol dehydrogenase
ISU58_RS05990	COG1879	ABC-type sugar transport system periplasmic component
ISU58_RS05995	COG1129	ABC transporter
ISU58_RS06000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS06005	COG1609	Transcriptional regulator
ISU58_RS06010	COG0583	DNA-binding transcription factor activity
ISU58_RS06015	COG0473	3-isopropylmalate dehydrogenase activity
ISU58_RS06025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU58_RS06035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_RS06040	COG2831	hemolysin activation secretion protein
ISU58_RS06045	COG3210	domain, Protein
ISU58_RS06085	COG3210	domain, Protein
ISU58_RS06095	COG3842	ATPase activity
ISU58_RS06105	COG1609	Transcriptional regulator
ISU58_RS06120	COG0395	ABC-type sugar transport system, permease component
ISU58_RS06125	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU58_RS06150	COG0668	transmembrane transport
ISU58_RS06155	COG1518	maintenance of DNA repeat elements
ISU58_RS06160	COG1203	CRISPR-associated helicase, Cas3
ISU58_RS06185	COG0667	Aldo Keto reductase
ISU58_RS06195	COG0477	Major facilitator Superfamily
ISU58_RS06205	COG0583	DNA-binding transcription factor activity
ISU58_RS06210	COG2771	luxR family
ISU58_RS06215	COG3916	Acyl-homoserine-lactone synthase
ISU58_RS06235	COG0628	permease
ISU58_RS06255	COG3328	transposase activity
ISU58_RS06265	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU58_RS06285	COG3328	transposase activity
ISU58_RS06290	COG1530	ribonuclease E activity
ISU58_RS06295	COG0564	pseudouridine synthase activity
ISU58_RS06300	COG0424	maF-like protein
ISU58_RS06305	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU58_RS06310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU58_RS06340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU58_RS06350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU58_RS06355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU58_RS06365	COG0470	DNA polymerase III
ISU58_RS06370	COG0084	hydrolase, TatD family'
ISU58_RS06375	COG1263	PTS System
ISU58_RS06375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_RS06400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU58_RS06405	COG0537	adenosine 5'-monophosphoramidase activity
ISU58_RS06410	COG5633	Lipoprotein
ISU58_RS06425	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU58_RS06435	COG1252	NADH dehydrogenase
ISU58_RS06450	COG3328	transposase activity
ISU58_RS06455	COG3134	Outer membrane lipoprotein
ISU58_RS06460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU58_RS06465	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU58_RS06475	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU58_RS06480	COG1940	carbohydrate kinase activity
ISU58_RS06500	COG2850	peptidyl-arginine hydroxylation
ISU58_RS06510	COG0745	RESPONSE REGULATOR receiver
ISU58_RS06520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU58_RS06540	COG1187	pseudouridine synthase activity
ISU58_RS06545	COG0538	isocitrate dehydrogenase activity
ISU58_RS06560	COG0840	transmembrane signaling receptor activity
ISU58_RS06565	COG0702	epimerase
ISU58_RS06570	COG1733	regulation of RNA biosynthetic process
ISU58_RS06595	COG1522	sequence-specific DNA binding
ISU58_RS06610	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS06610	COG3321	synthase
ISU58_RS06610	COG0604	alcohol dehydrogenase
ISU58_RS06635	COG1285	pathogenesis
ISU58_RS06660	COG1360	Flagellar Motor Protein
ISU58_RS06665	COG0643	Histidine kinase
ISU58_RS06665	COG2198	Histidine kinase
ISU58_RS06670	COG0835	chemotaxis
ISU58_RS06675	COG2271	Major facilitator Superfamily
ISU58_RS06680	COG0251	oxidation-reduction process
ISU58_RS06690	COG2964	Protein conserved in bacteria
ISU58_RS06710	COG0840	transmembrane signaling receptor activity
ISU58_RS06715	COG0840	transmembrane signaling receptor activity
ISU58_RS06720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU58_RS06730	COG0745	RESPONSE REGULATOR receiver
ISU58_RS06735	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU58_RS06740	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU58_RS06750	COG5295	Hep Hag repeat protein
ISU58_RS06760	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU58_RS06815	COG3121	Chaperone
ISU58_RS06835	COG3008	intermembrane lipid transfer
ISU58_RS06840	COG2995	paraquat-inducible protein a
ISU58_RS06845	COG1956	GAF domain-containing protein
ISU58_RS06855	COG0793	Belongs to the peptidase S41A family
ISU58_RS06865	COG3539	Fimbrial protein
ISU58_RS06870	COG3121	Chaperone
ISU58_RS06885	COG3121	Chaperone
ISU58_RS06890	COG2814	Major facilitator Superfamily
ISU58_RS06895	COG0823	Involved in the tonB-independent uptake of proteins
ISU58_RS06905	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU58_RS06910	COG1823	symporter activity
ISU58_RS06915	COG1988	membrane-bound metal-dependent
ISU58_RS06920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU58_RS06925	COG1653	transport
ISU58_RS06930	COG3842	ATPase activity
ISU58_RS06935	COG0395	ABC-type sugar transport system, permease component
ISU58_RS06940	COG1175	transmembrane transport
ISU58_RS06950	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS06960	COG1917	Cupin 2, conserved barrel domain protein
ISU58_RS06965	COG3328	transposase activity
ISU58_RS06970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_RS06980	COG3001	Fructosamine kinase
ISU58_RS06990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU58_RS06995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU58_RS07000	COG1121	(ABC) transporter
ISU58_RS07005	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU58_RS07025	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU58_RS07060	COG0072	phenylalanine-tRNA ligase activity
ISU58_RS07060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU58_RS07065	COG0776	regulation of translation
ISU58_RS07080	COG0386	Belongs to the glutathione peroxidase family
ISU58_RS07130	COG0791	NLP P60 protein
ISU58_RS07155	COG0574	Belongs to the PEP-utilizing enzyme family
ISU58_RS07155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU58_RS07165	COG0628	permease
ISU58_RS07170	COG0277	FAD linked oxidase domain protein
ISU58_RS07170	COG0247	lactate metabolic process
ISU58_RS07175	COG2050	protein possibly involved in aromatic compounds catabolism
ISU58_RS07180	COG0316	Belongs to the HesB IscA family
ISU58_RS07185	COG0719	Fe-S assembly protein
ISU58_RS07190	COG0396	ATPase activity
ISU58_RS07195	COG0719	Fe-S assembly protein
ISU58_RS07210	COG1388	LysM domain
ISU58_RS07210	COG1376	ErfK ybiS ycfS ynhG family protein
ISU58_RS07265	COG0307	riboflavin synthase, alpha
ISU58_RS07270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU58_RS07275	COG2814	Major facilitator Superfamily
ISU58_RS07280	COG0583	DNA-binding transcription factor activity
ISU58_RS07300	COG0791	NLP P60 protein
ISU58_RS07305	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU58_RS07315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU58_RS07320	COG0346	lactoylglutathione lyase activity
ISU58_RS07330	COG1309	transcriptional regulator
ISU58_RS07335	COG2194	sulfuric ester hydrolase activity
ISU58_RS07345	COG3133	Outer membrane lipoprotein
ISU58_RS07355	COG3895	Periplasmic Protein
ISU58_RS07375	COG0625	glutathione transferase activity
ISU58_RS07390	COG3104	oligopeptide transport
ISU58_RS07395	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU58_RS07395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU58_RS07400	COG4172	Belongs to the ABC transporter superfamily
ISU58_RS07410	COG4171	peptide transport system, permease
ISU58_RS07415	COG4168	peptide transport system, permease
ISU58_RS07420	COG4166	transmembrane transport
ISU58_RS07430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU58_RS07435	COG1842	Phage shock protein A
ISU58_RS07445	COG1983	PspC domain protein
ISU58_RS07455	COG3106	COG3106 Predicted ATPase
ISU58_RS07465	COG5654	RES domain protein
ISU58_RS07470	COG5642	Protein of unknown function (DUF2384)
ISU58_RS07485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU58_RS07490	COG4948	Mandelate Racemase Muconate Lactonizing
ISU58_RS07495	COG2866	Carboxypeptidase
ISU58_RS07500	COG4166	transmembrane transport
ISU58_RS07515	COG0657	acetylesterase activity
ISU58_RS07525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU58_RS07525	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU58_RS07525	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU58_RS07525	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU58_RS07535	COG1285	pathogenesis
ISU58_RS07540	COG3042	response to heat
ISU58_RS07545	COG3187	Heat shock protein
ISU58_RS07550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU58_RS07555	COG2911	Protein conserved in bacteria
ISU58_RS07565	COG3784	Protein of unknown function (DUF1318)
ISU58_RS07570	COG0246	Mannitol dehydrogenase
ISU58_RS07575	COG2390	Transcriptional regulator
ISU58_RS07585	COG1643	Atp-dependent helicase
ISU58_RS07600	COG3591	Belongs to the peptidase S1B family
ISU58_RS07640	COG1012	belongs to the aldehyde dehydrogenase family
ISU58_RS07640	COG1454	alcohol dehydrogenase
ISU58_RS07645	COG2095	MarC family integral membrane protein
ISU58_RS07655	COG0601	transmembrane transport
ISU58_RS07660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_RS07665	COG0444	Belongs to the ABC transporter superfamily
ISU58_RS07670	COG4608	Belongs to the ABC transporter superfamily
ISU58_RS07715	COG2350	Protein conserved in bacteria
ISU58_RS07720	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU58_RS07725	COG3328	transposase activity
ISU58_RS07760	COG3047	cAMP biosynthetic process
ISU58_RS07780	COG0135	phosphoribosylanthranilate isomerase activity
ISU58_RS07780	COG0134	indole-3-glycerol-phosphate synthase activity
ISU58_RS07790	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU58_RS07810	COG0009	L-threonylcarbamoyladenylate synthase
ISU58_RS07815	COG1187	pseudouridine synthase activity
ISU58_RS07825	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS07830	COG0616	signal peptide processing
ISU58_RS07850	COG0583	DNA-binding transcription factor activity
ISU58_RS07860	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISU58_RS07870	COG0671	phosphoesterase, PA-phosphatase related
ISU58_RS07875	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU58_RS07880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU58_RS07895	COG0023	Translation Initiation Factor
ISU58_RS07915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU58_RS07920	COG2879	small protein
ISU58_RS07925	COG1966	Carbon starvation protein
ISU58_RS07935	COG2271	Major facilitator Superfamily
ISU58_RS07940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_RS07945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU58_RS07955	COG4659	FMN binding
ISU58_RS07960	COG4658	electron transport chain
ISU58_RS07965	COG2207	Transcriptional regulator
ISU58_RS07965	COG3708	Transcriptional regulator
ISU58_RS07995	COG1132	(ABC) transporter
ISU58_RS08005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_RS08010	COG2274	protein secretion by the type I secretion system
ISU58_RS08025	COG1879	ABC-type sugar transport system periplasmic component
ISU58_RS08030	COG1129	ABC transporter
ISU58_RS08035	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS08045	COG0673	inositol 2-dehydrogenase activity
ISU58_RS08050	COG0385	Bile acid
ISU58_RS08060	COG5339	Protein conserved in bacteria
ISU58_RS08070	COG0114	fumarate hydratase activity
ISU58_RS08080	COG2814	Major facilitator Superfamily
ISU58_RS08085	COG0583	DNA-binding transcription factor activity
ISU58_RS08090	COG1940	carbohydrate kinase activity
ISU58_RS08095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU58_RS08100	COG0038	chloride channel
ISU58_RS08105	COG1609	Transcriptional regulator
ISU58_RS08125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU58_RS08135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU58_RS08165	COG0028	Belongs to the TPP enzyme family
ISU58_RS08170	COG0440	acetolactate synthase activity
ISU58_RS08175	COG1011	Hydrolase
ISU58_RS08190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU58_RS08195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU58_RS08200	COG0589	response to stress
ISU58_RS08205	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU58_RS08210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU58_RS08220	COG0531	amino acid
ISU58_RS08230	COG0745	RESPONSE REGULATOR receiver
ISU58_RS08235	COG2205	protein histidine kinase activity
ISU58_RS08240	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU58_RS08275	COG0745	RESPONSE REGULATOR receiver
ISU58_RS08285	COG0788	formyltetrahydrofolate deformylase activity
ISU58_RS08290	COG3328	transposase activity
ISU58_RS08310	COG0583	DNA-binding transcription factor activity
ISU58_RS08315	COG0708	Exodeoxyribonuclease III
ISU58_RS08320	COG0494	nUDIX hydrolase
ISU58_RS08330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU58_RS08335	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU58_RS08340	COG0778	Nitroreductase
ISU58_RS08345	COG0616	signal peptide processing
ISU58_RS08350	COG0252	asparaginase activity
ISU58_RS08355	COG1335	isochorismatase
ISU58_RS08360	COG3139	Protein of unknown function (DUF1315)
ISU58_RS08380	COG3713	MltA-interacting MipA family protein
ISU58_RS08385	COG2766	serine protein kinase
ISU58_RS08400	COG0583	DNA-binding transcription factor activity
ISU58_RS08410	COG2814	Major facilitator Superfamily
ISU58_RS08420	COG2719	SpoVR family
ISU58_RS08450	COG1104	cysteine desulfurase activity
ISU58_RS08460	COG3328	transposase activity
ISU58_RS08620	COG3328	transposase activity
ISU58_RS08720	COG0582	viral genome integration into host DNA
ISU58_RS08730	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU58_RS08735	COG2951	lytic endotransglycosylase activity
ISU58_RS08750	COG2894	cell division
ISU58_RS08755	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU58_RS08765	COG0318	PFAM AMP-dependent synthetase and ligase
ISU58_RS08785	COG1199	ATP-dependent helicase activity
ISU58_RS08790	COG0251	oxidation-reduction process
ISU58_RS08805	COG0800	Aldolase
ISU58_RS08810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU58_RS08815	COG1737	Transcriptional regulator
ISU58_RS08820	COG0469	pyruvate kinase activity
ISU58_RS08830	COG1560	Kdo2-lipid A biosynthetic process
ISU58_RS08835	COG0739	heme binding
ISU58_RS08840	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU58_RS08850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU58_RS08875	COG0494	nUDIX hydrolase
ISU58_RS08885	COG1801	Protein of unknown function DUF72
ISU58_RS08890	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU58_RS08910	COG3102	Protein conserved in bacteria
ISU58_RS08930	COG0728	peptidoglycan biosynthetic process
ISU58_RS08940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU58_RS08955	COG3381	protein complex oligomerization
ISU58_RS08970	COG1940	carbohydrate kinase activity
ISU58_RS08975	COG0584	glycerophosphoryl diester phosphodiesterase
ISU58_RS08995	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU58_RS09000	COG3833	ABC-type maltose transport systems, permease component
ISU58_RS09020	COG0659	secondary active sulfate transmembrane transporter activity
ISU58_RS09040	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU58_RS09065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU58_RS09080	COG0012	GTP binding
ISU58_RS09130	COG5002	protein histidine kinase activity
ISU58_RS09175	COG0500	methyltransferase
ISU58_RS09195	COG3328	transposase activity
ISU58_RS09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_RS09245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU58_RS09250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU58_RS09265	COG0402	S-adenosylhomocysteine deaminase activity
ISU58_RS09330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU58_RS09340	COG3850	Histidine kinase
ISU58_RS09345	COG0387	Pfam Sodium calcium exchanger
ISU58_RS09365	COG3658	cytochrome
ISU58_RS09375	COG1649	PFAM Uncharacterised BCR, COG1649
ISU58_RS09375	COG0726	polysaccharide deacetylase
ISU58_RS09380	COG0457	Tetratricopeptide repeat
ISU58_RS09385	COG0006	proline dipeptidase activity
ISU58_RS09405	COG0577	efflux transmembrane transporter activity
ISU58_RS09405	COG1136	(ABC) transporter
ISU58_RS09430	COG0672	)-iron permease
ISU58_RS09445	COG2066	Belongs to the glutaminase family
ISU58_RS09455	COG1349	DNA-binding transcription factor activity
ISU58_RS09465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU58_RS09470	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU58_RS09510	COG2030	dehydratase
ISU58_RS09545	COG3188	usher protein
ISU58_RS09555	COG3121	Chaperone
ISU58_RS09565	COG0582	viral genome integration into host DNA
ISU58_RS09570	COG1169	isochorismate synthase
ISU58_RS09575	COG2814	Major facilitator Superfamily
ISU58_RS09580	COG1132	(ABC) transporter
ISU58_RS09620	COG4771	TonB-dependent receptor
ISU58_RS09675	COG3842	ATPase activity
ISU58_RS09680	COG0395	ABC-type sugar transport system, permease component
ISU58_RS09685	COG1175	transmembrane transport
ISU58_RS09695	COG0673	inositol 2-dehydrogenase activity
ISU58_RS09700	COG2188	Transcriptional regulator
ISU58_RS09825	COG2197	response regulator
ISU58_RS09835	COG3136	membrane protein required for alginate biosynthesis
ISU58_RS09855	COG1113	amino acid transport
ISU58_RS09875	COG2822	iron ion transport
ISU58_RS09880	COG0672	)-iron permease
ISU58_RS09895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU58_RS09895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU58_RS09895	COG0506	proline dehydrogenase activity
ISU58_RS09910	COG1126	abc transporter atp-binding protein
ISU58_RS09915	COG0765	amino acid transport
ISU58_RS09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS09935	COG1191	sigma factor activity
ISU58_RS09965	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU58_RS09970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU58_RS09975	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU58_RS09995	COG1677	Flagellar hook-basal body complex protein FliE
ISU58_RS10015	COG1157	protein secretion by the type III secretion system
ISU58_RS10030	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU58_RS10055	COG1987	bacterial-type flagellum assembly
ISU58_RS10075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_RS10080	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS10085	COG1129	ABC transporter
ISU58_RS10095	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS10100	COG3347	Dehydrogenase
ISU58_RS10100	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS10105	COG2390	Transcriptional regulator
ISU58_RS10115	COG1256	bacterial-type flagellum assembly
ISU58_RS10155	COG1558	bacterial-type flagellum-dependent cell motility
ISU58_RS10160	COG1815	bacterial-type flagellum-dependent cell motility
ISU58_RS10170	COG2747	anti-sigma28 factor FlgM
ISU58_RS10175	COG3418	PFAM FlgN family protein
ISU58_RS10200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU58_RS10205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU58_RS10230	COG2372	response to copper ion
ISU58_RS10235	COG1528	Iron-storage protein
ISU58_RS10250	COG1770	oligopeptidase
ISU58_RS10265	COG3141	response to X-ray
ISU58_RS10270	COG0513	Belongs to the DEAD box helicase family
ISU58_RS10295	COG1760	l-serine dehydratase
ISU58_RS10300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU58_RS10305	COG2368	4-hydroxyphenylacetate
ISU58_RS10320	COG3971	2-oxopent-4-enoate hydratase activity
ISU58_RS10330	COG3384	dioxygenase
ISU58_RS10335	COG1012	belongs to the aldehyde dehydrogenase family
ISU58_RS10350	COG1846	Transcriptional regulator
ISU58_RS10355	COG1253	flavin adenine dinucleotide binding
ISU58_RS10360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_RS10360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_RS10365	COG3715	PTS system
ISU58_RS10370	COG3716	PTS system mannose fructose sorbose family IID component
ISU58_RS10400	COG2226	methyltransferase
ISU58_RS10405	COG1496	oxidoreductase activity
ISU58_RS10425	COG1113	amino acid transport
ISU58_RS10460	COG2207	Transcriptional regulator
ISU58_RS10470	COG1132	(ABC) transporter
ISU58_RS10515	COG3328	transposase activity
ISU58_RS10520	COG2223	nitrite transmembrane transporter activity
ISU58_RS10540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU58_RS10565	COG3122	Protein conserved in bacteria
ISU58_RS10585	COG0534	Mate efflux family protein
ISU58_RS10600	COG4948	Mandelate Racemase Muconate Lactonizing
ISU58_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS10615	COG3011	Protein conserved in bacteria
ISU58_RS10620	COG2271	Major facilitator Superfamily
ISU58_RS10625	COG1388	LysM domain
ISU58_RS10625	COG1470	cell adhesion involved in biofilm formation
ISU58_RS10630	COG3328	transposase activity
ISU58_RS10645	COG2925	Exonuclease
ISU58_RS10655	COG0531	amino acid
ISU58_RS10660	COG0371	Dehydrogenase
ISU58_RS10665	COG1129	ABC transporter
ISU58_RS10670	COG1129	ABC transporter
ISU58_RS10675	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS10690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_RS10705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU58_RS10715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU58_RS10715	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU58_RS10735	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU58_RS10735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU58_RS10745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU58_RS10750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU58_RS10765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU58_RS10770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS10775	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS10780	COG1120	ATPase activity
ISU58_RS10795	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU58_RS10800	COG0076	glutamate decarboxylase activity
ISU58_RS10805	COG4114	ferric iron reductase
ISU58_RS10810	COG1253	flavin adenine dinucleotide binding
ISU58_RS10815	COG2982	Protein involved in outer membrane biogenesis
ISU58_RS10830	COG0489	protein tyrosine kinase activity
ISU58_RS10860	COG2814	Major facilitator Superfamily
ISU58_RS10870	COG1346	cytolysis
ISU58_RS10885	COG2949	membrane
ISU58_RS10890	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS10905	COG2311	Membrane
ISU58_RS10915	COG0477	Major facilitator Superfamily
ISU58_RS10920	COG0583	DNA-binding transcription factor activity
ISU58_RS10950	COG1136	(ABC) transporter
ISU58_RS10960	COG0303	'Molybdopterin
ISU58_RS10970	COG3328	transposase activity
ISU58_RS10980	COG0488	(ABC) transporter
ISU58_RS11110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU58_RS11115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU58_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS11140	COG3425	synthase
ISU58_RS11145	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS11150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU58_RS11155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU58_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS11190	COG2920	part of a sulfur-relay system
ISU58_RS11210	COG1832	CoA-binding protein
ISU58_RS11225	COG0210	DNA helicase
ISU58_RS11230	COG3304	Inner membrane component domain
ISU58_RS11235	COG1289	transmembrane transporter activity
ISU58_RS11240	COG3070	regulator of competence-specific genes
ISU58_RS11265	COG1067	ATP-dependent peptidase activity
ISU58_RS11305	COG3130	regulation of translation
ISU58_RS11310	COG3009	Protein conserved in bacteria
ISU58_RS11315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU58_RS11315	COG3008	intermembrane lipid transfer
ISU58_RS11320	COG2995	paraquat-inducible protein a
ISU58_RS11325	COG0488	(ABC) transporter
ISU58_RS11335	COG3217	Mosc domain protein beta barrel domain protein
ISU58_RS11335	COG0633	Ferredoxin
ISU58_RS11350	COG0308	aminopeptidase N
ISU58_RS11370	COG1448	Aminotransferase
ISU58_RS11380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU58_RS11385	COG3108	Peptidase M15
ISU58_RS11390	COG2989	Protein conserved in bacteria
ISU58_RS11415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU58_RS11420	COG3173	Aminoglycoside phosphotransferase
ISU58_RS11435	COG1278	Cold shock
ISU58_RS11440	COG5383	Protein conserved in bacteria
ISU58_RS11455	COG0658	competence protein
ISU58_RS11455	COG2333	competence protein COMEC
ISU58_RS11465	COG0539	negative regulation of cytoplasmic translation
ISU58_RS11490	COG5295	Hep Hag repeat protein
ISU58_RS11490	COG5295	Hep Hag repeat protein
ISU58_RS11495	COG0252	asparaginase activity
ISU58_RS11500	COG1944	ATP diphosphatase activity
ISU58_RS11505	COG2116	formate transmembrane transporter activity
ISU58_RS11510	COG1882	Formate acetyltransferase
ISU58_RS11520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU58_RS11550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU58_RS11560	COG3107	peptidoglycan biosynthetic process
ISU58_RS11560	COG1674	ftsk spoiiie
ISU58_RS11570	COG0492	ferredoxin-NADP+ reductase activity
ISU58_RS11580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU58_RS11590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU58_RS11600	COG0542	response to heat
ISU58_RS11610	COG1278	Cold shock
ISU58_RS11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_RS11625	COG2990	Protein conserved in bacteria
ISU58_RS11630	COG3593	DNA synthesis involved in DNA repair
ISU58_RS11635	COG2431	L-lysine efflux transmembrane transporter activity
ISU58_RS11645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_RS11650	COG0028	Belongs to the TPP enzyme family
ISU58_RS11660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU58_RS11665	COG0702	epimerase
ISU58_RS11670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU58_RS11680	COG1605	Chorismate mutase
ISU58_RS11685	COG1126	abc transporter atp-binding protein
ISU58_RS11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS11695	COG4215	(ABC) transporter
ISU58_RS11700	COG4160	amino acid transport
ISU58_RS11725	COG1120	ATPase activity
ISU58_RS11730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS11735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS11760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS11775	COG1177	transmembrane transport
ISU58_RS11780	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU58_RS11785	COG3842	ATPase activity
ISU58_RS11790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU58_RS11820	COG0671	phosphoesterase, PA-phosphatase related
ISU58_RS11830	COG1349	DNA-binding transcription factor activity
ISU58_RS11835	COG0814	amino acid
ISU58_RS11840	COG1686	Belongs to the peptidase S11 family
ISU58_RS11845	COG2011	ABC-type metal ion transport system permease component
ISU58_RS11870	COG0625	glutathione transferase activity
ISU58_RS11875	COG4771	TonB-dependent receptor
ISU58_RS11885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS11900	COG0583	DNA-binding transcription factor activity
ISU58_RS11905	COG2855	membrane
ISU58_RS11915	COG3188	usher protein
ISU58_RS11920	COG3121	Chaperone
ISU58_RS11935	COG3710	Transcriptional regulator
ISU58_RS11940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU58_RS11940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_RS11940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_RS11945	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU58_RS11955	COG0494	nUDIX hydrolase
ISU58_RS11965	COG1129	ABC transporter
ISU58_RS12000	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS12025	COG0246	Mannitol dehydrogenase
ISU58_RS12030	COG2186	Transcriptional regulator
ISU58_RS12040	COG0671	phosphoesterase, PA-phosphatase related
ISU58_RS12045	COG0791	NLP P60 protein
ISU58_RS12050	COG2200	EAL domain
ISU58_RS12055	COG4166	transmembrane transport
ISU58_RS12060	COG4174	ABC transporter (Permease)
ISU58_RS12065	COG4239	(ABC) transporter, permease
ISU58_RS12070	COG4172	Belongs to the ABC transporter superfamily
ISU58_RS12080	COG2814	Major facilitator Superfamily
ISU58_RS12085	COG1187	pseudouridine synthase activity
ISU58_RS12090	COG1061	Type III restriction enzyme res subunit
ISU58_RS12110	COG3082	Protein of unknown function (DUF1414)
ISU58_RS12115	COG3083	sulfuric ester hydrolase activity
ISU58_RS12130	COG3157	Type VI secretion system effector, Hcp
ISU58_RS12150	COG2723	6-phospho-beta-galactosidase activity
ISU58_RS12155	COG1737	Transcriptional regulator
ISU58_RS12175	COG3299	homolog of phage Mu protein gp47
ISU58_RS12215	COG4386	tail sheath protein
ISU58_RS12235	COG3622	Belongs to the hyi family
ISU58_RS12240	COG1349	DNA-binding transcription factor activity
ISU58_RS12290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU58_RS12315	COG2223	nitrite transmembrane transporter activity
ISU58_RS12320	COG2198	Histidine kinase
ISU58_RS12320	COG0642	Histidine kinase
ISU58_RS12325	COG2198	Histidine kinase
ISU58_RS12325	COG0642	Histidine kinase
ISU58_RS12335	COG0784	Response regulator, receiver
ISU58_RS12335	COG2205	protein histidine kinase activity
ISU58_RS12360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU58_RS12375	COG0814	amino acid
ISU58_RS12410	COG0697	spore germination
ISU58_RS12420	COG1982	Orn Lys Arg decarboxylase major
ISU58_RS12425	COG0531	amino acid
ISU58_RS12430	COG1174	glycine betaine transport
ISU58_RS12435	COG1125	glycine betaine transport
ISU58_RS12440	COG1174	glycine betaine transport
ISU58_RS12450	COG2897	thiosulfate sulfurtransferase activity
ISU58_RS12470	COG1122	ATPase activity
ISU58_RS12490	COG4807	Protein conserved in bacteria
ISU58_RS12505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU58_RS12515	COG2261	transglycosylase associated protein
ISU58_RS12535	COG0277	FAD linked oxidase domain protein
ISU58_RS12540	COG1686	Belongs to the peptidase S11 family
ISU58_RS12550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU58_RS12565	COG0670	Belongs to the BI1 family
ISU58_RS12570	COG0314	molybdopterin synthase activity
ISU58_RS12575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU58_RS12585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU58_RS12590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU58_RS12595	COG4628	conserved protein (DUF2132)
ISU58_RS12605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU58_RS12615	COG2226	methyltransferase
ISU58_RS12640	COG0561	phosphatase activity
ISU58_RS12650	COG4149	molybdate abc transporter
ISU58_RS12655	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU58_RS12665	COG2005	Transcriptional regulator
ISU58_RS12665	COG3585	molybdate ion transport
ISU58_RS12670	COG1119	ATPase activity
ISU58_RS12680	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU58_RS12685	COG1085	galactose-1-phosphate uridylyltransferase
ISU58_RS12700	COG2017	converts alpha-aldose to the beta-anomer
ISU58_RS12715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU58_RS12720	COG1230	cation diffusion facilitator family transporter
ISU58_RS12750	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU58_RS12755	COG2885	chlorophyll binding
ISU58_RS12765	COG3064	Membrane
ISU58_RS12765	COG3064	Membrane
ISU58_RS12770	COG0848	biopolymer transport protein
ISU58_RS12775	COG0811	peptide transport
ISU58_RS12780	COG0824	Thioesterase
ISU58_RS12785	COG3790	cyd operon protein YbgE
ISU58_RS12790	COG4890	Cyd operon protein YbgT
ISU58_RS12795	COG1294	oxidase, subunit
ISU58_RS12800	COG1271	oxidase subunit
ISU58_RS12805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU58_RS12815	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU58_RS12820	COG0567	Dehydrogenase, E1 component
ISU58_RS12830	COG1053	succinate dehydrogenase
ISU58_RS12835	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU58_RS12840	COG2009	succinate dehydrogenase
ISU58_RS12855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU58_RS12860	COG0497	DNA recombination
ISU58_RS12865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU58_RS12875	COG2867	negative regulation of translational initiation
ISU58_RS12895	COG0582	viral genome integration into host DNA
ISU58_RS12945	COG3657	addiction module killer protein
ISU58_RS12970	COG1953	Uracil, thiamine, allantoin
ISU58_RS12990	COG2226	methyltransferase
ISU58_RS13000	COG1388	LysM domain
ISU58_RS13000	COG0741	lytic transglycosylase activity
ISU58_RS13015	COG0656	L-ascorbic acid biosynthetic process
ISU58_RS13045	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU58_RS13055	COG2011	ABC-type metal ion transport system permease component
ISU58_RS13060	COG1464	Belongs to the NlpA lipoprotein family
ISU58_RS13070	COG1720	tRNA m6t6A37 methyltransferase activity
ISU58_RS13080	COG3015	lipoprotein NlpE involved in copper resistance
ISU58_RS13090	COG4681	YaeQ
ISU58_RS13100	COG4568	rho-dependent transcription termination
ISU58_RS13110	COG0037	tRNA processing
ISU58_RS13115	COG0346	lactoylglutathione lyase activity
ISU58_RS13125	COG0587	DNA-directed DNA polymerase activity
ISU58_RS13150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU58_RS13165	COG0750	zinc metalloprotease
ISU58_RS13170	COG0575	Belongs to the CDS family
ISU58_RS13230	COG0564	pseudouridine synthase activity
ISU58_RS13235	COG3098	single-species biofilm formation
ISU58_RS13255	COG1611	Belongs to the LOG family
ISU58_RS13280	COG2363	Small membrane protein
ISU58_RS13285	COG0583	DNA-binding transcription factor activity
ISU58_RS13295	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU58_RS13300	COG2166	iron-sulfur cluster assembly
ISU58_RS13305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU58_RS13310	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU58_RS13325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU58_RS13335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU58_RS13340	COG1074	ATP-dependent DNA helicase activity
ISU58_RS13350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU58_RS13400	COG0667	Aldo Keto reductase
ISU58_RS13430	COG1609	Transcriptional regulator
ISU58_RS13440	COG0583	DNA-binding transcription factor activity
ISU58_RS13445	COG2814	Major facilitator Superfamily
ISU58_RS13450	COG0583	DNA-binding transcription factor activity
ISU58_RS13465	COG0840	transmembrane signaling receptor activity
ISU58_RS13510	COG2165	general secretion pathway protein
ISU58_RS13530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU58_RS13550	COG0288	reversible hydration of carbon dioxide
ISU58_RS13590	COG3119	arylsulfatase activity
ISU58_RS13595	COG1349	DNA-binding transcription factor activity
ISU58_RS13605	COG2222	sugar isomerase
ISU58_RS13610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_RS13615	COG3715	PTS system
ISU58_RS13620	COG3716	PTS system mannose fructose sorbose family IID component
ISU58_RS13625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
ISU58_RS13645	COG0641	radical SAM
ISU58_RS13650	COG3119	arylsulfatase activity
ISU58_RS13675	COG2271	Major facilitator Superfamily
ISU58_RS13695	COG1263	PTS System
ISU58_RS13695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_RS13700	COG1874	Beta-galactosidase
ISU58_RS13705	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU58_RS13710	COG3833	ABC-type maltose transport systems, permease component
ISU58_RS13715	COG1175	transmembrane transport
ISU58_RS13720	COG2182	Extracellular solute-binding protein
ISU58_RS13730	COG1129	ABC transporter
ISU58_RS13735	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS13740	COG1879	ABC-type sugar transport system periplasmic component
ISU58_RS13750	COG0791	NLP P60 protein
ISU58_RS13755	COG1695	Transcriptional regulator
ISU58_RS13845	COG2944	sequence-specific DNA binding
ISU58_RS13870	COG0582	viral genome integration into host DNA
ISU58_RS13890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU58_RS13895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU58_RS13900	COG4974	Belongs to the 'phage' integrase family
ISU58_RS13905	COG0716	FMN binding
ISU58_RS13910	COG4452	Inner membrane protein CreD
ISU58_RS13915	COG2205	protein histidine kinase activity
ISU58_RS13920	COG0745	RESPONSE REGULATOR receiver
ISU58_RS13945	COG1272	protein, Hemolysin III
ISU58_RS13990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU58_RS13995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU58_RS14000	COG0006	proline dipeptidase activity
ISU58_RS14020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU58_RS14030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU58_RS14065	COG0191	fructose-bisphosphate aldolase activity
ISU58_RS14085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU58_RS14090	COG0501	Belongs to the peptidase M48B family
ISU58_RS14105	COG1166	arginine decarboxylase activity
ISU58_RS14120	COG2356	endonuclease I
ISU58_RS14125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU58_RS14130	COG0189	ligase activity
ISU58_RS14145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU58_RS14155	COG2805	Type II/IV secretion system protein
ISU58_RS14160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU58_RS14165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU58_RS14170	COG0762	integral membrane protein
ISU58_RS14180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU58_RS14185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU58_RS14190	COG1073	alpha beta
ISU58_RS14190	COG3064	Membrane
ISU58_RS14190	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU58_RS14210	COG3171	Protein conserved in bacteria
ISU58_RS14220	COG1194	a g-specific adenine glycosylase
ISU58_RS14240	COG4774	siderophore transport
ISU58_RS14245	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS14250	COG1129	ABC transporter
ISU58_RS14255	COG1879	ABC-type sugar transport system periplasmic component
ISU58_RS14260	COG1982	Orn Lys Arg decarboxylase major
ISU58_RS14380	COG3916	Acyl-homoserine-lactone synthase
ISU58_RS14385	COG2771	luxR family
ISU58_RS14435	COG2211	Major facilitator Superfamily
ISU58_RS14445	COG5001	Diguanylate cyclase
ISU58_RS14455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_RS14500	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU58_RS14505	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU58_RS14510	COG4771	TonB-dependent receptor
ISU58_RS14535	COG3433	isochorismatase activity
ISU58_RS14535	COG2226	methyltransferase
ISU58_RS14535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU58_RS14540	COG2226	methyltransferase
ISU58_RS14540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU58_RS14540	COG3433	isochorismatase activity
ISU58_RS14565	COG1132	(ABC) transporter
ISU58_RS14565	COG2375	cellular response to nickel ion
ISU58_RS14570	COG1132	(ABC) transporter
ISU58_RS14585	COG2610	gluconate transmembrane transporter activity
ISU58_RS14600	COG3501	Rhs element vgr protein
ISU58_RS14625	COG0471	metal ion transport
ISU58_RS14650	COG3710	Transcriptional regulator
ISU58_RS14670	COG1256	bacterial-type flagellum assembly
ISU58_RS14680	COG1706	bacterial-type flagellum-dependent cell motility
ISU58_RS14690	COG4786	Flagellar basal body rod
ISU58_RS14695	COG4787	bacterial-type flagellum-dependent cell motility
ISU58_RS14700	COG1749	Flagellar hook protein flgE
ISU58_RS14705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU58_RS14710	COG1558	bacterial-type flagellum-dependent cell motility
ISU58_RS14715	COG1815	bacterial-type flagellum-dependent cell motility
ISU58_RS14720	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU58_RS14760	COG1677	Flagellar hook-basal body complex protein FliE
ISU58_RS14785	COG1987	bacterial-type flagellum assembly
ISU58_RS14790	COG1684	flagellar biosynthetic protein fliR
ISU58_RS14795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU58_RS14815	COG4592	Periplasmic binding protein
ISU58_RS14850	COG4964	Belongs to the GSP D family
ISU58_RS14855	COG4964	Belongs to the GSP D family
ISU58_RS14905	COG0848	biopolymer transport protein
ISU58_RS14910	COG0811	peptide transport
ISU58_RS14915	COG0626	cystathionine gamma-synthase activity
ISU58_RS14920	COG0586	Pfam SNARE associated Golgi protein
ISU58_RS14925	COG2207	Transcriptional regulator
ISU58_RS14930	COG1979	alcohol dehydrogenase
ISU58_RS14940	COG0656	L-ascorbic acid biosynthetic process
ISU58_RS14950	COG2132	Multicopper oxidase
ISU58_RS14960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU58_RS14970	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU58_RS14975	COG0583	DNA-binding transcription factor activity
ISU58_RS14985	COG3150	esterase
ISU58_RS14990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU58_RS14995	COG3151	Protein conserved in bacteria
ISU58_RS15000	COG0494	nUDIX hydrolase
ISU58_RS15005	COG1538	Outer membrane efflux protein
ISU58_RS15015	COG0754	glutathionylspermidine amidase activity
ISU58_RS15020	COG3384	dioxygenase
ISU58_RS15040	COG0531	amino acid
ISU58_RS15055	COG3025	triphosphatase activity
ISU58_RS15060	COG4991	sh3 domain protein
ISU58_RS15075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU58_RS15090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU58_RS15095	COG0358	DNA primase activity
ISU58_RS15165	COG0251	oxidation-reduction process
ISU58_RS15205	COG1289	transmembrane transporter activity
ISU58_RS15225	COG0395	ABC-type sugar transport system, permease component
ISU58_RS15235	COG2182	Extracellular solute-binding protein
ISU58_RS15240	COG1609	Transcriptional regulator
ISU58_RS15245	COG3459	Glycosyltransferase 36 associated
ISU58_RS15250	COG3842	ATPase activity
ISU58_RS15270	COG3210	domain, Protein
ISU58_RS15275	COG3210	domain, Protein
ISU58_RS15305	COG3210	domain, Protein
ISU58_RS15310	COG2831	hemolysin activation secretion protein
ISU58_RS15315	COG4245	von Willebrand factor, type A
ISU58_RS15330	COG4245	von Willebrand factor, type A
ISU58_RS15345	COG3247	response to pH
ISU58_RS15350	COG1902	pentaerythritol trinitrate reductase activity
ISU58_RS15350	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU58_RS15365	COG1451	nucleotide metabolic process
ISU58_RS15370	COG0673	inositol 2-dehydrogenase activity
ISU58_RS15390	COG2721	sulfolactate sulfo-lyase activity
ISU58_RS15405	COG2271	Major facilitator Superfamily
ISU58_RS15420	COG0586	Pfam SNARE associated Golgi protein
ISU58_RS15435	COG4575	ribosome binding
ISU58_RS15440	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU58_RS15450	COG2259	Doxx family
ISU58_RS15470	COG0494	nUDIX hydrolase
ISU58_RS15500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU58_RS15505	COG0849	cell division
ISU58_RS15510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU58_RS15530	COG0772	Belongs to the SEDS family
ISU58_RS15545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU58_RS15550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU58_RS15555	COG0768	penicillin binding
ISU58_RS15560	COG3116	cell division
ISU58_RS15585	COG1609	Transcriptional regulator
ISU58_RS15600	COG0028	Belongs to the TPP enzyme family
ISU58_RS15605	COG1022	Amp-dependent synthetase and ligase
ISU58_RS15630	COG0473	3-isopropylmalate dehydrogenase activity
ISU58_RS15645	COG2814	Major facilitator Superfamily
ISU58_RS15655	COG4143	(ABC) transporter
ISU58_RS15660	COG1178	ABC-type Fe3 transport system permease component
ISU58_RS15665	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU58_RS15670	COG0586	Pfam SNARE associated Golgi protein
ISU58_RS15675	COG0417	DNA replication proofreading
ISU58_RS15695	COG2885	chlorophyll binding
ISU58_RS15695	COG3047	cAMP biosynthetic process
ISU58_RS15780	COG0564	pseudouridine synthase activity
ISU58_RS15785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU58_RS15835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU58_RS15845	COG2966	Psort location CytoplasmicMembrane, score
ISU58_RS15850	COG1280	lysine exporter protein (LysE YggA)
ISU58_RS15855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU58_RS15880	COG1047	Peptidyl-prolyl cis-trans
ISU58_RS15895	COG0196	riboflavin kinase activity
ISU58_RS15905	COG0583	DNA-binding transcription factor activity
ISU58_RS15925	COG1584	GPR1 FUN34 yaaH family protein
ISU58_RS15940	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU58_RS15980	COG0745	RESPONSE REGULATOR receiver
ISU58_RS15985	COG3045	CreA protein
ISU58_RS15990	COG3708	Transcriptional regulator
ISU58_RS15990	COG2207	Transcriptional regulator
ISU58_RS16005	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU58_RS16010	COG0741	lytic transglycosylase activity
ISU58_RS16025	COG2199	diguanylate cyclase activity
ISU58_RS16030	COG2885	chlorophyll binding
ISU58_RS16055	COG0560	Phosphoserine phosphatase
ISU58_RS16060	COG3726	membrane protein affecting hemolysin expression
ISU58_RS16085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU58_RS16090	COG0084	hydrolase, TatD family'
ISU58_RS16095	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU58_RS16105	COG2823	Periplasmic or secreted lipoprotein
ISU58_RS16115	COG0456	acetyltransferase
ISU58_RS16120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU58_RS16160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU58_RS16165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU58_RS16180	COG0859	PFAM glycosyl transferase family 9
ISU58_RS16185	COG1070	Carbohydrate kinase
ISU58_RS16250	COG1401	restriction endodeoxyribonuclease activity
ISU58_RS16305	COG4269	membrane
ISU58_RS16315	COG2207	Transcriptional regulator
ISU58_RS16320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_RS16325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_RS16330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU58_RS16360	COG1011	Hydrolase
ISU58_RS16370	COG0174	glutamine synthetase
ISU58_RS16375	COG3852	Histidine kinase
ISU58_RS16385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU58_RS16410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU58_RS16410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU58_RS16415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU58_RS16420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU58_RS16425	COG3084	Protein conserved in bacteria
ISU58_RS16435	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU58_RS16440	COG3328	transposase activity
ISU58_RS16480	COG2271	Major facilitator Superfamily
ISU58_RS16495	COG2831	hemolysin activation secretion protein
ISU58_RS16500	COG0747	negative chemotaxis
ISU58_RS16505	COG0601	transmembrane transport
ISU58_RS16510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU58_RS16515	COG0444	Belongs to the ABC transporter superfamily
ISU58_RS16520	COG4608	Belongs to the ABC transporter superfamily
ISU58_RS16525	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU58_RS16530	COG2200	EAL domain
ISU58_RS16530	COG2199	diguanylate cyclase activity
ISU58_RS16535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU58_RS16555	COG0612	Peptidase, M16
ISU58_RS16560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_RS16565	COG1942	4-Oxalocrotonate Tautomerase
ISU58_RS16570	COG2200	EAL domain
ISU58_RS16575	COG2982	Protein involved in outer membrane biogenesis
ISU58_RS16580	COG2134	cdp-diacylglycerol pyrophosphatase
ISU58_RS16585	COG1295	ribonuclease BN
ISU58_RS16610	COG1929	Belongs to the glycerate kinase type-1 family
ISU58_RS16625	COG3835	regulator
ISU58_RS16630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU58_RS16635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU58_RS16640	COG0339	signal peptide processing
ISU58_RS16660	COG0589	response to stress
ISU58_RS16675	COG0306	phosphate transporter
ISU58_RS16680	COG2081	HI0933 family
ISU58_RS16695	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS16710	COG0191	fructose-bisphosphate aldolase activity
ISU58_RS16730	COG1741	Belongs to the pirin family
ISU58_RS16735	COG1609	Transcriptional regulator
ISU58_RS16740	COG2610	gluconate transmembrane transporter activity
ISU58_RS16745	COG3265	gluconokinase activity
ISU58_RS16760	COG2095	MarC family integral membrane protein
ISU58_RS16765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU58_RS16800	COG3275	phosphorelay sensor kinase activity
ISU58_RS16825	COG0058	SHG alpha-glucan phosphorylase activity
ISU58_RS16830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU58_RS16875	COG0195	Participates in both transcription termination and antitermination
ISU58_RS16895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU58_RS16905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU58_RS16920	COG1534	Rna-binding protein
ISU58_RS16930	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU58_RS16935	COG0745	RESPONSE REGULATOR receiver
ISU58_RS16940	COG0642	Histidine kinase
ISU58_RS16950	COG0697	spore germination
ISU58_RS16965	COG0142	geranyltranstransferase activity
ISU58_RS16975	COG3423	Transcriptional regulator
ISU58_RS16995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU58_RS17000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU58_RS17005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU58_RS17010	COG2105	PFAM AIG2 family protein
ISU58_RS17015	COG2911	Protein conserved in bacteria
ISU58_RS17020	COG0729	surface antigen
ISU58_RS17030	COG1253	flavin adenine dinucleotide binding
ISU58_RS17040	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU58_RS17050	COG0737	Belongs to the 5'-nucleotidase family
ISU58_RS17060	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU58_RS17065	COG3061	Opacity-associated protein A
ISU58_RS17085	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU58_RS17095	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU58_RS17100	COG1073	alpha beta
ISU58_RS17120	COG3650	response to hydrogen peroxide
ISU58_RS17125	COG1960	acyl-CoA dehydrogenase activity
ISU58_RS17130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU58_RS17135	COG0557	exoribonuclease II activity
ISU58_RS17150	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU58_RS17155	COG0330	HflC and HflK could
ISU58_RS17160	COG0330	HflC and HflK could
ISU58_RS17165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU58_RS17185	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU58_RS17190	COG0802	atpase or kinase
ISU58_RS17195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU58_RS17195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU58_RS17200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU58_RS17215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU58_RS17230	COG3264	Mechanosensitive ion channel
ISU58_RS17230	COG1511	domain protein
ISU58_RS17245	COG1053	succinate dehydrogenase
ISU58_RS17250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU58_RS17260	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU58_RS17320	COG3383	formate dehydrogenase (NAD+) activity
ISU58_RS17325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_RS17330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU58_RS17330	COG0493	'glutamate synthase
ISU58_RS17335	COG1309	transcriptional regulator
ISU58_RS17395	COG1454	alcohol dehydrogenase
ISU58_RS17405	COG0629	single-stranded DNA binding
ISU58_RS17410	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU58_RS17415	COG2315	Protein conserved in bacteria
ISU58_RS17420	COG1448	Aminotransferase
ISU58_RS17445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU58_RS17450	COG0735	belongs to the Fur family
ISU58_RS17460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU58_RS17500	COG3121	Chaperone
ISU58_RS17560	COG1358	cellular component organization or biogenesis
ISU58_RS17585	COG3721	Heme iron utilization protein
ISU58_RS17590	COG0702	epimerase
ISU58_RS17600	COG4771	TonB-dependent receptor
ISU58_RS17605	COG3720	iron ion transport
ISU58_RS17610	COG4558	Periplasmic binding protein
ISU58_RS17615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU58_RS17625	COG0626	cystathionine gamma-synthase activity
ISU58_RS17630	COG0814	amino acid
ISU58_RS17635	COG0583	DNA-binding transcription factor activity
ISU58_RS17640	COG0425	Belongs to the sulfur carrier protein TusA family
ISU58_RS17645	COG2391	methyltransferase activity
ISU58_RS17755	COG1301	dicarboxylic acid transport
ISU58_RS17765	COG3162	membrane
ISU58_RS17825	COG0151	Belongs to the GarS family
ISU58_RS17845	COG1515	deoxyribonuclease V activity
ISU58_RS17880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU58_RS17935	COG0250	Participates in transcription elongation, termination and antitermination
ISU58_RS17995	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU58_RS18025	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU58_RS18030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU58_RS18045	COG1739	Uncharacterized protein family UPF0029
ISU58_RS18070	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU58_RS18105	COG0805	protein transport
ISU58_RS18115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU58_RS18135	COG1322	Protein conserved in bacteria
ISU58_RS18140	COG0586	Pfam SNARE associated Golgi protein
ISU58_RS18145	COG1966	Carbon starvation protein
ISU58_RS18160	COG0412	Dienelactone hydrolase
ISU58_RS18170	COG0583	DNA-binding transcription factor activity
ISU58_RS18175	COG0697	spore germination
ISU58_RS18180	COG0679	Auxin Efflux Carrier
ISU58_RS18185	COG0584	glycerophosphoryl diester phosphodiesterase
ISU58_RS18245	COG0410	ABC transporter
ISU58_RS18255	COG4177	L-phenylalanine transmembrane transporter activity
ISU58_RS18265	COG0683	leucine binding
ISU58_RS18285	COG2177	Part of the ABC transporter FtsEX involved in
ISU58_RS18290	COG2884	Cell division ATP-binding protein ftsE
ISU58_RS18295	COG0552	protein localization to endoplasmic reticulum
ISU58_RS18295	COG0552	protein localization to endoplasmic reticulum
ISU58_RS18300	COG0742	ribosomal rna small subunit methyltransferase
ISU58_RS18305	COG3776	membrane
ISU58_RS18320	COG3714	YhhN family
ISU58_RS18335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU58_RS18345	COG0247	lactate metabolic process
ISU58_RS18355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU58_RS18360	COG0584	glycerophosphoryl diester phosphodiesterase
ISU58_RS18370	COG0561	phosphatase activity
ISU58_RS18375	COG2267	carboxylic ester hydrolase activity
ISU58_RS18380	COG1280	lysine exporter protein (LysE YggA)
ISU58_RS18385	COG1280	lysine exporter protein (LysE YggA)
ISU58_RS18390	COG0514	ATP-dependent DNA helicase (RecQ)
ISU58_RS18395	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU58_RS18400	COG2050	protein possibly involved in aromatic compounds catabolism
ISU58_RS18415	COG5564	TIM-barrel signal transduction protein
ISU58_RS18420	COG5441	Belongs to the UPF0261 family
ISU58_RS18430	COG0210	DNA helicase
ISU58_RS18435	COG1011	Hydrolase
ISU58_RS18440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU58_RS18445	COG3159	Protein conserved in bacteria
ISU58_RS18465	COG3072	Adenylate cyclase
ISU58_RS18480	COG1587	Uroporphyrinogen-III synthase
ISU58_RS18485	COG2959	enzyme of heme biosynthesis
ISU58_RS18490	COG3071	HemY protein
ISU58_RS18520	COG1113	amino acid transport
ISU58_RS18540	COG2244	polysaccharide biosynthetic process
ISU58_RS18545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU58_RS18550	COG0456	acetyltransferase
ISU58_RS18555	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU58_RS18560	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU58_RS18565	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU58_RS18570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU58_RS18575	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU58_RS18580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU58_RS18585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU58_RS18590	COG3118	belongs to the thioredoxin family
ISU58_RS18615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU58_RS18625	COG3328	transposase activity
ISU58_RS18635	COG3121	Chaperone
ISU58_RS18650	COG3121	Chaperone
ISU58_RS18685	COG0583	DNA-binding transcription factor activity
ISU58_RS18730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU58_RS18735	COG3978	acetolactate synthase activity
ISU58_RS18755	COG3085	chromosome segregation
ISU58_RS18765	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS18770	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS18775	COG1129	ABC transporter
ISU58_RS18780	COG1879	ABC-type sugar transport system periplasmic component
ISU58_RS18850	COG0678	peroxiredoxin activity
ISU58_RS18850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU58_RS18855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU58_RS18880	COG1629	transport
ISU58_RS18895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU58_RS18920	COG0460	homoserine dehydrogenase
ISU58_RS18920	COG0527	aspartate kinase activity
ISU58_RS18935	COG4682	membrane
ISU58_RS18945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU58_RS18950	COG1609	Transcriptional regulator
ISU58_RS18955	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU58_RS18970	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU58_RS19020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU58_RS19025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU58_RS19030	COG1494	fructose-1,6-bisphosphatase
ISU58_RS19040	COG3152	Membrane
ISU58_RS19055	COG0583	DNA-binding transcription factor activity
ISU58_RS19060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU58_RS19065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU58_RS19070	COG0471	metal ion transport
ISU58_RS19080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU58_RS19105	COG3678	ATP-independent chaperone mediated protein folding
ISU58_RS19110	COG0745	RESPONSE REGULATOR receiver
ISU58_RS19115	COG2205	protein histidine kinase activity
ISU58_RS19120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU58_RS19120	COG2169	Transcriptional regulator
ISU58_RS19125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU58_RS19130	COG1045	serine acetyltransferase
ISU58_RS19145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU58_RS19150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU58_RS19160	COG4942	peptidase
ISU58_RS19175	COG0156	8-amino-7-oxononanoate synthase activity
ISU58_RS19185	COG0859	PFAM glycosyl transferase family 9
ISU58_RS19190	COG0859	PFAM glycosyl transferase family 9
ISU58_RS19195	COG1519	Transferase
ISU58_RS19230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU58_RS19255	COG1561	YicC-like family, N-terminal region
ISU58_RS19260	COG2860	membrane
ISU58_RS19280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU58_RS19285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU58_RS19290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU58_RS19300	COG0786	glutamate:sodium symporter activity
ISU58_RS19305	COG2233	PERMEase
ISU58_RS19310	COG2982	Protein involved in outer membrane biogenesis
ISU58_RS19315	COG0456	acetyltransferase
ISU58_RS19335	COG0583	DNA-binding transcription factor activity
ISU58_RS19340	COG1741	Belongs to the pirin family
ISU58_RS19350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU58_RS19370	COG2823	Periplasmic or secreted lipoprotein
ISU58_RS19380	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU58_RS19385	COG2198	Histidine kinase
ISU58_RS19385	COG5002	protein histidine kinase activity
ISU58_RS19385	COG0784	Response regulator, receiver
ISU58_RS19390	COG1242	4 iron, 4 sulfur cluster binding
ISU58_RS19395	COG0069	glutamate synthase activity
ISU58_RS19395	COG0067	glutamate synthase
ISU58_RS19395	COG0070	glutamate synthase
ISU58_RS19400	COG0493	'glutamate synthase
ISU58_RS19410	COG2969	positive regulation of protein catabolic process
ISU58_RS19415	COG0625	glutathione transferase activity
ISU58_RS19435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU58_RS19440	COG3105	Protein conserved in bacteria
ISU58_RS19445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU58_RS19455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU58_RS19465	COG5007	Belongs to the BolA IbaG family
ISU58_RS19470	COG3113	response to antibiotic
ISU58_RS19475	COG2854	intermembrane phospholipid transfer
ISU58_RS19480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU58_RS19485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU58_RS19490	COG1127	ABC transporter
ISU58_RS19495	COG0530	calcium, potassium:sodium antiporter activity
ISU58_RS19500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU58_RS19500	COG0517	IMP dehydrogenase activity
ISU58_RS19505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU58_RS19510	COG3117	lipopolysaccharide transmembrane transporter activity
ISU58_RS19515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU58_RS19520	COG1137	ATPase activity
ISU58_RS19525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU58_RS19545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU58_RS19570	COG1609	Transcriptional regulator
ISU58_RS19575	COG1263	PTS System
ISU58_RS19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU58_RS19580	COG0366	Alpha amylase catalytic
ISU58_RS19585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU58_RS19590	COG3783	Cytochrome b(562)
ISU58_RS19600	COG0312	modulator of DNA gyrase
ISU58_RS19610	COG2732	(Barnase) inhibitor
ISU58_RS19640	COG0583	DNA-binding transcription factor activity
ISU58_RS19690	COG0312	modulator of DNA gyrase
ISU58_RS19695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU58_RS19700	COG3164	Protein of unknown function
ISU58_RS19705	COG1530	ribonuclease E activity
ISU58_RS19710	COG0424	maF-like protein
ISU58_RS19715	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU58_RS19720	COG1792	Involved in formation and maintenance of cell shape
ISU58_RS19725	COG1077	Cell shape determining protein MreB Mrl
ISU58_RS19730	COG2199	diguanylate cyclase activity
ISU58_RS19730	COG2200	EAL domain
ISU58_RS19735	COG0604	alcohol dehydrogenase
ISU58_RS19740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU58_RS19755	COG0511	ligase activity, forming carbon-carbon bonds
ISU58_RS19760	COG0439	Biotin carboxylase
ISU58_RS19770	COG3924	membrane
ISU58_RS19775	COG4145	pantothenate transmembrane transporter activity
ISU58_RS19785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU58_RS19790	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU58_RS19820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU58_RS19830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU58_RS19835	COG3133	Outer membrane lipoprotein
ISU58_RS19840	COG1278	Cold shock
ISU58_RS19845	COG1278	Cold shock
ISU58_RS19865	COG0625	glutathione transferase activity
ISU58_RS19875	COG1069	ribulokinase activity
ISU58_RS19885	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU58_RS19890	COG1129	ABC transporter
ISU58_RS19900	COG1560	Kdo2-lipid A biosynthetic process
ISU58_RS19910	COG0025	NhaP-type Na H and K H
ISU58_RS19915	COG2252	PERMEase
ISU58_RS19920	COG3077	Addiction module antitoxin, RelB DinJ family
ISU58_RS19935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU58_RS19945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU58_RS19950	COG0431	NADPH-dependent FMN reductase
ISU58_RS19955	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU58_RS19960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_RS19965	COG1869	D-ribose catabolic process
ISU58_RS19970	COG1917	Cupin 2, conserved barrel domain protein
ISU58_RS19970	COG2207	Transcriptional regulator
ISU58_RS19975	COG0673	inositol 2-dehydrogenase activity
ISU58_RS19995	COG3209	COG3209 Rhs family protein
ISU58_RS20005	COG3501	Rhs element vgr protein
ISU58_RS20050	COG3501	Rhs element vgr protein
ISU58_RS20195	COG1175	transmembrane transport
ISU58_RS20200	COG3833	ABC-type maltose transport systems, permease component
ISU58_RS20215	COG0527	aspartate kinase activity
ISU58_RS20245	COG2224	Isocitrate lyase
ISU58_RS20250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU58_RS20290	COG2186	Transcriptional regulator
ISU58_RS20295	COG0477	Major facilitator Superfamily
ISU58_RS20310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU58_RS20340	COG1522	sequence-specific DNA binding
ISU58_RS20345	COG0716	FMN binding
ISU58_RS20360	COG3312	ion transport
ISU58_RS20415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU58_RS20420	COG0573	inorganic phosphate transmembrane transporter activity
ISU58_RS20425	COG0581	inorganic phosphate transmembrane transporter activity
ISU58_RS20435	COG0704	Plays a role in the regulation of phosphate uptake
ISU58_RS20445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU58_RS20450	COG0765	amino acid transport
ISU58_RS20455	COG0765	amino acid transport
ISU58_RS20460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU58_RS20470	COG2252	PERMEase
ISU58_RS20500	COG0706	membrane insertase activity
ISU58_RS20515	COG0230	Belongs to the bacterial ribosomal protein bL34 family