locus-tag	class	description
ISU65_RS00010	COG0592	DNA-directed DNA polymerase activity
ISU65_RS00025	COG0187	DNA topoisomerase II activity
ISU65_RS00030	COG0561	phosphatase activity
ISU65_RS00040	COG2423	ornithine cyclodeaminase activity
ISU65_RS00045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISU65_RS00055	COG5645	(Lipo)protein
ISU65_RS00075	COG3977	Valine--pyruvate aminotransferase
ISU65_RS00085	COG0366	Alpha amylase catalytic
ISU65_RS00100	COG2885	chlorophyll binding
ISU65_RS00110	COG2818	Glycosylase
ISU65_RS00135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS00135	COG2213	PTS system mannitol-specific
ISU65_RS00145	COG3722	fumarate hydratase activity
ISU65_RS00170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISU65_RS00185	COG0437	4 iron, 4 sulfur cluster binding
ISU65_RS00190	COG2864	formate dehydrogenase
ISU65_RS00205	COG3276	selenocysteine insertion sequence binding
ISU65_RS00250	COG3274	enterobacterial common antigen metabolic process
ISU65_RS00265	COG3121	Chaperone
ISU65_RS00275	COG1070	Carbohydrate kinase
ISU65_RS00285	COG4213	ABC transporter substrate-binding protein
ISU65_RS00295	COG4214	carbohydrate transport
ISU65_RS00300	COG2207	Transcriptional regulator
ISU65_RS00300	COG1609	Transcriptional regulator
ISU65_RS00310	COG0582	viral genome integration into host DNA
ISU65_RS00355	COG4604	ABC transporter, ATP-binding protein
ISU65_RS00360	COG4605	iron ion homeostasis
ISU65_RS00370	COG4607	ABC-type enterochelin transport system periplasmic component
ISU65_RS00400	COG2986	histidine ammonia-lyase
ISU65_RS00415	COG2194	sulfuric ester hydrolase activity
ISU65_RS00420	COG2197	response regulator
ISU65_RS00440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ISU65_RS00455	COG0551	DNA topoisomerase type I activity
ISU65_RS00465	COG0758	DNA mediated transformation
ISU65_RS00495	COG3036	rescue of stalled ribosome
ISU65_RS00500	COG0789	Transcriptional regulator
ISU65_RS00515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISU65_RS00530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU65_RS00535	COG0201	protein transport
ISU65_RS00545	COG1841	ribosomal large subunit assembly
ISU65_RS00585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISU65_RS00590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISU65_RS00600	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISU65_RS00605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISU65_RS00615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISU65_RS00625	COG0089	rRNA binding
ISU65_RS00640	COG0051	transcription antitermination factor activity, RNA binding
ISU65_RS00670	COG0049	tRNA binding
ISU65_RS00675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ISU65_RS00695	COG2964	Protein conserved in bacteria
ISU65_RS00700	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU65_RS00710	COG1047	Peptidyl-prolyl cis-trans
ISU65_RS00715	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ISU65_RS00735	COG1216	Glycosyl transferase, family 2
ISU65_RS00745	COG2175	clavaminate synthase activity
ISU65_RS00750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU65_RS00760	COG4521	taurine ABC transporter
ISU65_RS00770	COG0429	hydrolase of the alpha beta-hydrolase fold
ISU65_RS00780	COG3954	Phosphoribulokinase
ISU65_RS00790	COG1765	OsmC-like protein
ISU65_RS00800	COG1289	transmembrane transporter activity
ISU65_RS00815	COG0433	COG0433 Predicted ATPase
ISU65_RS00820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU65_RS00825	COG1486	melibiose metabolic process
ISU65_RS00845	COG0402	S-adenosylhomocysteine deaminase activity
ISU65_RS00850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISU65_RS00885	COG0180	Tryptophanyl-tRNA synthetase
ISU65_RS00890	COG0546	phosphoglycolate phosphatase activity
ISU65_RS00895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISU65_RS00920	COG4796	Type ii and iii secretion system protein
ISU65_RS00945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ISU65_RS00950	COG0494	nUDIX hydrolase
ISU65_RS00960	COG1011	Hydrolase
ISU65_RS00965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISU65_RS00990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU65_RS00995	COG2183	response to ionizing radiation
ISU65_RS01000	COG1918	ferrous iron import across plasma membrane
ISU65_RS01035	COG1640	4-alpha-glucanotransferase
ISU65_RS01040	COG0058	SHG alpha-glucan phosphorylase activity
ISU65_RS01045	COG0058	SHG alpha-glucan phosphorylase activity
ISU65_RS01065	COG1349	DNA-binding transcription factor activity
ISU65_RS01090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU65_RS01095	COG0058	SHG alpha-glucan phosphorylase activity
ISU65_RS01120	COG3275	phosphorelay sensor kinase activity
ISU65_RS01155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU65_RS01160	COG2095	MarC family integral membrane protein
ISU65_RS01175	COG3265	gluconokinase activity
ISU65_RS01180	COG2610	gluconate transmembrane transporter activity
ISU65_RS01185	COG1609	Transcriptional regulator
ISU65_RS01190	COG1741	Belongs to the pirin family
ISU65_RS01210	COG0191	fructose-bisphosphate aldolase activity
ISU65_RS01225	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS01240	COG2081	HI0933 family
ISU65_RS01245	COG0306	phosphate transporter
ISU65_RS01260	COG0589	response to stress
ISU65_RS01280	COG0339	signal peptide processing
ISU65_RS01285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ISU65_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU65_RS01295	COG3835	regulator
ISU65_RS01305	COG2610	gluconate transmembrane transporter activity
ISU65_RS01310	COG1929	Belongs to the glycerate kinase type-1 family
ISU65_RS01335	COG1295	ribonuclease BN
ISU65_RS01340	COG2134	cdp-diacylglycerol pyrophosphatase
ISU65_RS01345	COG2982	Protein involved in outer membrane biogenesis
ISU65_RS01350	COG2200	EAL domain
ISU65_RS01355	COG1942	4-Oxalocrotonate Tautomerase
ISU65_RS01360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_RS01365	COG0612	Peptidase, M16
ISU65_RS01385	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU65_RS01390	COG2199	diguanylate cyclase activity
ISU65_RS01390	COG2200	EAL domain
ISU65_RS01395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ISU65_RS01400	COG4608	Belongs to the ABC transporter superfamily
ISU65_RS01405	COG0444	Belongs to the ABC transporter superfamily
ISU65_RS01410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_RS01415	COG0601	transmembrane transport
ISU65_RS01420	COG0747	negative chemotaxis
ISU65_RS01425	COG2831	hemolysin activation secretion protein
ISU65_RS01440	COG2271	Major facilitator Superfamily
ISU65_RS01490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU65_RS01490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISU65_RS01495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU65_RS01500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ISU65_RS01505	COG3084	Protein conserved in bacteria
ISU65_RS01515	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISU65_RS01520	COG3328	transposase activity
ISU65_RS01535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU65_RS01545	COG3852	Histidine kinase
ISU65_RS01550	COG0174	glutamine synthetase
ISU65_RS01560	COG1011	Hydrolase
ISU65_RS01585	COG1401	restriction endodeoxyribonuclease activity
ISU65_RS01640	COG4269	membrane
ISU65_RS01650	COG2207	Transcriptional regulator
ISU65_RS01655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_RS01660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_RS01665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_RS01670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS01670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU65_RS01670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS01720	COG1070	Carbohydrate kinase
ISU65_RS01725	COG0859	PFAM glycosyl transferase family 9
ISU65_RS01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_RS01745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_RS01785	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ISU65_RS01790	COG0456	acetyltransferase
ISU65_RS01800	COG2823	Periplasmic or secreted lipoprotein
ISU65_RS01810	COG4667	esterase of the alpha-beta hydrolase superfamily
ISU65_RS01815	COG0084	hydrolase, TatD family'
ISU65_RS01820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU65_RS01845	COG3726	membrane protein affecting hemolysin expression
ISU65_RS01850	COG0560	Phosphoserine phosphatase
ISU65_RS01875	COG2885	chlorophyll binding
ISU65_RS01880	COG2199	diguanylate cyclase activity
ISU65_RS01895	COG0741	lytic transglycosylase activity
ISU65_RS01900	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ISU65_RS01915	COG2207	Transcriptional regulator
ISU65_RS01915	COG3708	Transcriptional regulator
ISU65_RS01920	COG3045	CreA protein
ISU65_RS01925	COG0745	RESPONSE REGULATOR receiver
ISU65_RS01965	COG0521	Mo-molybdopterin cofactor biosynthetic process
ISU65_RS01980	COG1584	GPR1 FUN34 yaaH family protein
ISU65_RS02000	COG0583	DNA-binding transcription factor activity
ISU65_RS02010	COG0196	riboflavin kinase activity
ISU65_RS02025	COG1047	Peptidyl-prolyl cis-trans
ISU65_RS02050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISU65_RS02055	COG1280	lysine exporter protein (LysE YggA)
ISU65_RS02060	COG2966	Psort location CytoplasmicMembrane, score
ISU65_RS02070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ISU65_RS02120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ISU65_RS02125	COG0564	pseudouridine synthase activity
ISU65_RS02225	COG2885	chlorophyll binding
ISU65_RS02225	COG3047	cAMP biosynthetic process
ISU65_RS02245	COG0417	DNA replication proofreading
ISU65_RS02250	COG0586	Pfam SNARE associated Golgi protein
ISU65_RS02255	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ISU65_RS02260	COG1178	ABC-type Fe3 transport system permease component
ISU65_RS02265	COG4143	(ABC) transporter
ISU65_RS02275	COG2814	Major facilitator Superfamily
ISU65_RS02290	COG0473	3-isopropylmalate dehydrogenase activity
ISU65_RS02315	COG1022	Amp-dependent synthetase and ligase
ISU65_RS02320	COG0028	Belongs to the TPP enzyme family
ISU65_RS02335	COG1609	Transcriptional regulator
ISU65_RS02360	COG3116	cell division
ISU65_RS02365	COG0768	penicillin binding
ISU65_RS02370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISU65_RS02375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISU65_RS02390	COG0772	Belongs to the SEDS family
ISU65_RS02410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ISU65_RS02415	COG0849	cell division
ISU65_RS02420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISU65_RS02450	COG0494	nUDIX hydrolase
ISU65_RS02470	COG2259	Doxx family
ISU65_RS02480	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ISU65_RS02485	COG4575	ribosome binding
ISU65_RS02500	COG0586	Pfam SNARE associated Golgi protein
ISU65_RS02515	COG2271	Major facilitator Superfamily
ISU65_RS02530	COG2721	sulfolactate sulfo-lyase activity
ISU65_RS02550	COG0673	inositol 2-dehydrogenase activity
ISU65_RS02555	COG1451	nucleotide metabolic process
ISU65_RS02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISU65_RS02570	COG1902	pentaerythritol trinitrate reductase activity
ISU65_RS02575	COG3247	response to pH
ISU65_RS02590	COG4245	von Willebrand factor, type A
ISU65_RS02605	COG4245	von Willebrand factor, type A
ISU65_RS02610	COG2831	hemolysin activation secretion protein
ISU65_RS02615	COG3210	domain, Protein
ISU65_RS02645	COG3210	domain, Protein
ISU65_RS02650	COG3210	domain, Protein
ISU65_RS02670	COG3842	ATPase activity
ISU65_RS02675	COG3459	Glycosyltransferase 36 associated
ISU65_RS02680	COG1609	Transcriptional regulator
ISU65_RS02685	COG2182	Extracellular solute-binding protein
ISU65_RS02695	COG0395	ABC-type sugar transport system, permease component
ISU65_RS02715	COG1289	transmembrane transporter activity
ISU65_RS02735	COG0436	Aminotransferase
ISU65_RS02755	COG0251	oxidation-reduction process
ISU65_RS02825	COG0358	DNA primase activity
ISU65_RS02830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ISU65_RS02845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ISU65_RS02860	COG4991	sh3 domain protein
ISU65_RS02865	COG3025	triphosphatase activity
ISU65_RS02880	COG0531	amino acid
ISU65_RS02900	COG3384	dioxygenase
ISU65_RS02905	COG0754	glutathionylspermidine amidase activity
ISU65_RS02915	COG1538	Outer membrane efflux protein
ISU65_RS02920	COG0494	nUDIX hydrolase
ISU65_RS02925	COG3151	Protein conserved in bacteria
ISU65_RS02930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ISU65_RS02935	COG3150	esterase
ISU65_RS02945	COG0583	DNA-binding transcription factor activity
ISU65_RS02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISU65_RS02960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISU65_RS02970	COG2132	Multicopper oxidase
ISU65_RS02980	COG0656	L-ascorbic acid biosynthetic process
ISU65_RS02990	COG1979	alcohol dehydrogenase
ISU65_RS02995	COG2207	Transcriptional regulator
ISU65_RS03000	COG0586	Pfam SNARE associated Golgi protein
ISU65_RS03005	COG0626	cystathionine gamma-synthase activity
ISU65_RS03010	COG0811	peptide transport
ISU65_RS03015	COG0848	biopolymer transport protein
ISU65_RS03065	COG4964	Belongs to the GSP D family
ISU65_RS03070	COG4964	Belongs to the GSP D family
ISU65_RS03105	COG4592	Periplasmic binding protein
ISU65_RS03125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU65_RS03130	COG1684	flagellar biosynthetic protein fliR
ISU65_RS03135	COG1987	bacterial-type flagellum assembly
ISU65_RS03160	COG1677	Flagellar hook-basal body complex protein FliE
ISU65_RS03200	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
ISU65_RS03205	COG1815	bacterial-type flagellum-dependent cell motility
ISU65_RS03210	COG1558	bacterial-type flagellum-dependent cell motility
ISU65_RS03215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ISU65_RS03220	COG1749	Flagellar hook protein flgE
ISU65_RS03225	COG4787	bacterial-type flagellum-dependent cell motility
ISU65_RS03230	COG4786	Flagellar basal body rod
ISU65_RS03240	COG1706	bacterial-type flagellum-dependent cell motility
ISU65_RS03270	COG3710	Transcriptional regulator
ISU65_RS03295	COG0471	metal ion transport
ISU65_RS03320	COG3501	Rhs element vgr protein
ISU65_RS03335	COG2610	gluconate transmembrane transporter activity
ISU65_RS03350	COG1132	(ABC) transporter
ISU65_RS03355	COG1132	(ABC) transporter
ISU65_RS03355	COG2375	cellular response to nickel ion
ISU65_RS03380	COG3433	isochorismatase activity
ISU65_RS03380	COG2226	methyltransferase
ISU65_RS03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU65_RS03390	COG2226	methyltransferase
ISU65_RS03390	COG3433	isochorismatase activity
ISU65_RS03390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU65_RS03430	COG1459	type II secretion system
ISU65_RS03435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU65_RS03440	COG4969	Belongs to the N-Me-Phe pilin family
ISU65_RS03450	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU65_RS03455	COG3725	Membrane protein required for beta-lactamase induction
ISU65_RS03460	COG1113	amino acid transport
ISU65_RS03465	COG2186	Transcriptional regulator
ISU65_RS03470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ISU65_RS03475	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU65_RS03480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU65_RS03490	COG1049	propionate catabolic process, 2-methylcitrate cycle
ISU65_RS03500	COG0697	spore germination
ISU65_RS03520	COG2132	Multicopper oxidase
ISU65_RS03525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ISU65_RS03530	COG0288	reversible hydration of carbon dioxide
ISU65_RS03535	COG1131	(ABC) transporter
ISU65_RS03540	COG0842	Transport permease protein
ISU65_RS03565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISU65_RS03570	COG0617	tRNA 3'-terminal CCA addition
ISU65_RS03575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISU65_RS03590	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISU65_RS03595	COG1643	Atp-dependent helicase
ISU65_RS03600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISU65_RS03605	COG1120	ATPase activity
ISU65_RS03610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU65_RS03615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS03635	COG2860	membrane
ISU65_RS03655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU65_RS03660	COG3437	response regulator, receiver
ISU65_RS03660	COG3850	Histidine kinase
ISU65_RS03660	COG2205	protein histidine kinase activity
ISU65_RS03660	COG4999	Histidine kinase
ISU65_RS03670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ISU65_RS03675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU65_RS03680	COG3956	TIGRFAM MazG family protein
ISU65_RS03700	COG0602	queuosine metabolic process
ISU65_RS03705	COG0720	synthase
ISU65_RS03760	COG0529	Catalyzes the synthesis of activated sulfate
ISU65_RS03800	COG4942	peptidase
ISU65_RS03800	COG1388	LysM domain
ISU65_RS03805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISU65_RS03815	COG0698	ribose 5-phosphate isomerase
ISU65_RS03820	COG1063	alcohol dehydrogenase
ISU65_RS03825	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS03830	COG2376	Dihydroxyacetone kinase
ISU65_RS03845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISU65_RS03865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS03870	COG1858	cytochrome C peroxidase
ISU65_RS03880	COG4771	TonB-dependent receptor
ISU65_RS03890	COG0024	Methionine aminopeptidase
ISU65_RS03900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU65_RS03900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ISU65_RS03905	COG1070	Carbohydrate kinase
ISU65_RS03910	COG3623	hexulose-6-phosphate isomerase
ISU65_RS03915	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS03920	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS03925	COG1129	ABC transporter
ISU65_RS03940	COG1349	DNA-binding transcription factor activity
ISU65_RS03945	COG0235	Class ii aldolase
ISU65_RS03950	COG0243	molybdopterin cofactor binding
ISU65_RS03955	COG0437	4 iron, 4 sulfur cluster binding
ISU65_RS03960	COG3302	dmso reductase anchor subunit
ISU65_RS03965	COG3381	protein complex oligomerization
ISU65_RS03970	COG3038	cytochrome b561
ISU65_RS03975	COG3783	Cytochrome b(562)
ISU65_RS03985	COG1879	ABC-type sugar transport system periplasmic component
ISU65_RS03995	COG1129	ABC transporter
ISU65_RS04000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS04005	COG3959	Transketolase, thiamine diphosphate binding domain
ISU65_RS04010	COG3958	Transketolase
ISU65_RS04015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU65_RS04055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ISU65_RS04085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_RS04090	COG1238	metal cluster binding
ISU65_RS04095	COG2918	glutathione biosynthetic process
ISU65_RS04110	COG4536	flavin adenine dinucleotide binding
ISU65_RS04115	COG4137	Cytochrome C assembly protein
ISU65_RS04120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISU65_RS04150	COG3137	Salt-induced outer membrane protein
ISU65_RS04160	COG3279	Response regulator of the LytR AlgR family
ISU65_RS04165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU65_RS04170	COG1605	Chorismate mutase
ISU65_RS04170	COG0287	Prephenate dehydrogenase
ISU65_RS04200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISU65_RS04205	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU65_RS04210	COG0564	pseudouridine synthase activity
ISU65_RS04220	COG0542	response to heat
ISU65_RS04250	COG5544	Lipoprotein
ISU65_RS04255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISU65_RS04260	COG1042	CoA-binding domain protein
ISU65_RS04260	COG0045	succinate-CoA ligase (ADP-forming) activity
ISU65_RS04260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU65_RS04265	COG3148	PFAM DTW domain containing protein
ISU65_RS04270	COG3118	belongs to the thioredoxin family
ISU65_RS04275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU65_RS04280	COG2814	Major facilitator Superfamily
ISU65_RS04285	COG1566	PFAM secretion protein HlyD family protein
ISU65_RS04290	COG1846	Transcriptional regulator
ISU65_RS04300	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ISU65_RS04305	COG2814	Major facilitator Superfamily
ISU65_RS04340	COG0765	amino acid transport
ISU65_RS04350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU65_RS04365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ISU65_RS04390	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
ISU65_RS04400	COG1960	acyl-CoA dehydrogenase activity
ISU65_RS04410	COG0121	glutamine amidotransferase
ISU65_RS04415	COG3034	peptidoglycan biosynthetic process
ISU65_RS04425	COG1805	sodium ion transport
ISU65_RS04430	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU65_RS04450	COG1477	protein flavinylation
ISU65_RS04470	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU65_RS04475	COG0583	DNA-binding transcription factor activity
ISU65_RS04525	COG2226	methyltransferase
ISU65_RS04550	COG1940	carbohydrate kinase activity
ISU65_RS04555	COG0419	ATPase involved in DNA repair
ISU65_RS04560	COG0420	3'-5' exonuclease activity
ISU65_RS04565	COG0745	RESPONSE REGULATOR receiver
ISU65_RS04570	COG5002	protein histidine kinase activity
ISU65_RS04590	COG0366	Alpha amylase catalytic
ISU65_RS04610	COG0450	alkyl hydroperoxide reductase
ISU65_RS04630	COG1862	Preprotein translocase
ISU65_RS04640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISU65_RS04665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU65_RS04665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISU65_RS04680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ISU65_RS04685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ISU65_RS04700	COG0142	geranyltranstransferase activity
ISU65_RS04715	COG0693	protein deglycase activity
ISU65_RS04720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISU65_RS04730	COG2814	Major facilitator Superfamily
ISU65_RS04740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISU65_RS04745	COG1845	cytochrome c oxidase, subunit III
ISU65_RS04750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ISU65_RS04755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISU65_RS04765	COG2223	nitrite transmembrane transporter activity
ISU65_RS04770	COG3056	Lipoprotein
ISU65_RS04775	COG0271	Belongs to the BolA IbaG family
ISU65_RS04795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ISU65_RS04800	COG0776	regulation of translation
ISU65_RS04805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU65_RS04810	COG1555	photosystem II stabilization
ISU65_RS04815	COG0824	Thioesterase
ISU65_RS04825	COG4533	DNA binding
ISU65_RS04840	COG1522	sequence-specific DNA binding
ISU65_RS04845	COG1132	(ABC) transporter
ISU65_RS04850	COG1132	(ABC) transporter
ISU65_RS04855	COG0347	Belongs to the P(II) protein family
ISU65_RS04880	COG1946	Acyl-CoA thioesterase
ISU65_RS04885	COG3126	Type III secretion system lipoprotein chaperone (YscW)
ISU65_RS04890	COG3695	enzyme binding
ISU65_RS04915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISU65_RS04925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_RS04930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_RS04935	COG1309	transcriptional regulator
ISU65_RS04940	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ISU65_RS04945	COG1196	nuclear chromosome segregation
ISU65_RS04945	COG3264	Mechanosensitive ion channel
ISU65_RS04960	COG2832	Protein of unknown function (DUF454)
ISU65_RS04970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISU65_RS05000	COG0543	2 iron, 2 sulfur cluster binding
ISU65_RS05000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_RS05020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_RS05060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_RS05080	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU65_RS05085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_RS05090	COG4651	solute:proton antiporter activity
ISU65_RS05090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU65_RS05095	COG2223	nitrite transmembrane transporter activity
ISU65_RS05110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISU65_RS05115	COG3735	TraB family
ISU65_RS05120	COG2217	Heavy metal translocating P-type atpase
ISU65_RS05125	COG0789	Transcriptional regulator
ISU65_RS05130	COG1585	Membrane protein implicated in regulation of membrane protease activity
ISU65_RS05135	COG0330	HflC and HflK could
ISU65_RS05140	COG3118	belongs to the thioredoxin family
ISU65_RS05145	COG0300	oxidoreductase activity
ISU65_RS05150	COG2755	lipolytic protein G-D-S-L family
ISU65_RS05155	COG4181	ATPase activity
ISU65_RS05160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ISU65_RS05165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISU65_RS05170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISU65_RS05180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISU65_RS05195	COG2501	S4 domain
ISU65_RS05230	COG0582	viral genome integration into host DNA
ISU65_RS05240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ISU65_RS05245	COG4589	Belongs to the CDS family
ISU65_RS05255	COG2267	carboxylic ester hydrolase activity
ISU65_RS05260	COG0671	phosphoesterase, PA-phosphatase related
ISU65_RS05260	COG2453	phosphatase
ISU65_RS05290	COG0667	Aldo Keto reductase
ISU65_RS05295	COG0656	L-ascorbic acid biosynthetic process
ISU65_RS05305	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU65_RS05320	COG3328	transposase activity
ISU65_RS05375	COG3423	Transcriptional regulator
ISU65_RS05380	COG4953	penicillin-binding protein 1C
ISU65_RS05390	COG2373	Large extracellular alpha-helical protein
ISU65_RS05410	COG3962	Belongs to the TPP enzyme family
ISU65_RS05425	COG1129	ABC transporter
ISU65_RS05430	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS05435	COG0673	inositol 2-dehydrogenase activity
ISU65_RS05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_RS05450	COG3718	enzyme involved in inositol metabolism
ISU65_RS05460	COG5265	(ABC) transporter
ISU65_RS05485	COG2197	response regulator
ISU65_RS05490	COG1278	Cold shock
ISU65_RS05500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU65_RS05505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU65_RS05525	COG1686	Belongs to the peptidase S11 family
ISU65_RS05530	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU65_RS05535	COG0772	Belongs to the SEDS family
ISU65_RS05540	COG0768	penicillin binding
ISU65_RS05550	COG0799	negative regulation of ribosome biogenesis
ISU65_RS05560	COG1466	dna polymerase III delta subunit
ISU65_RS05575	COG2888	peptidyl-tyrosine sulfation
ISU65_RS05580	COG1126	abc transporter atp-binding protein
ISU65_RS05585	COG0765	amino acid transport
ISU65_RS05590	COG0765	amino acid transport
ISU65_RS05600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ISU65_RS05605	COG4535	Mg2 and Co2 transporter CorC
ISU65_RS05615	COG1702	phosphate starvation-inducible protein PhoH
ISU65_RS05620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISU65_RS05625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU65_RS05660	COG0367	asparagine synthase
ISU65_RS05665	COG0647	UMP catabolic process
ISU65_RS05670	COG1846	Transcriptional regulator
ISU65_RS05670	COG1940	carbohydrate kinase activity
ISU65_RS05675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISU65_RS05685	COG2190	(PTS) system
ISU65_RS05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_RS05685	COG1263	PTS System
ISU65_RS05710	COG0735	belongs to the Fur family
ISU65_RS05725	COG0596	Alpha beta hydrolase
ISU65_RS05735	COG0582	viral genome integration into host DNA
ISU65_RS05770	COG2113	Glycine betaine
ISU65_RS05775	COG4176	ABC-type proline glycine betaine transport system permease component
ISU65_RS05780	COG4175	Glycine betaine
ISU65_RS05785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISU65_RS05825	COG1278	Cold shock
ISU65_RS05830	COG0747	negative chemotaxis
ISU65_RS05840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_RS05845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ISU65_RS05850	COG1124	(ABC) transporter
ISU65_RS05855	COG0831	urea catabolic process
ISU65_RS05880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ISU65_RS05890	COG4413	Urea transporter
ISU65_RS05895	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU65_RS05905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ISU65_RS05915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISU65_RS05925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU65_RS05930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISU65_RS05935	COG1447	Phosphotransferase system cellobiose-specific component IIA
ISU65_RS05940	COG2169	Transcriptional regulator
ISU65_RS05940	COG1917	Cupin 2, conserved barrel domain protein
ISU65_RS05955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ISU65_RS05960	COG0033	Phosphoglucomutase
ISU65_RS05975	COG0745	RESPONSE REGULATOR receiver
ISU65_RS05980	COG2205	protein histidine kinase activity
ISU65_RS06015	COG3272	Protein of unknown function (DUF1722)
ISU65_RS06025	COG5212	phosphodiesterase
ISU65_RS06030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ISU65_RS06045	COG1984	allophanate hydrolase subunit 2
ISU65_RS06090	COG0513	Belongs to the DEAD box helicase family
ISU65_RS06100	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ISU65_RS06115	COG3026	antisigma factor binding
ISU65_RS06120	COG3086	response to oxidative stress
ISU65_RS06155	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ISU65_RS06170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_RS06175	COG1737	Transcriptional regulator
ISU65_RS06185	COG0560	Phosphoserine phosphatase
ISU65_RS06230	COG2205	protein histidine kinase activity
ISU65_RS06235	COG3170	Tfp pilus assembly protein FimV
ISU65_RS06240	COG2204	response regulator
ISU65_RS06245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU65_RS06245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISU65_RS06250	COG0347	Belongs to the P(II) protein family
ISU65_RS06275	COG1017	nitric oxide dioxygenase activity
ISU65_RS06275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_RS06295	COG2814	Major facilitator Superfamily
ISU65_RS06300	COG3711	transcriptional antiterminator
ISU65_RS06305	COG3683	transport system, periplasmic component
ISU65_RS06310	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ISU65_RS06330	COG1104	cysteine desulfurase activity
ISU65_RS06335	COG0822	iron-sulfur transferase activity
ISU65_RS06355	COG0633	Ferredoxin
ISU65_RS06360	COG2975	iron-sulfur cluster assembly
ISU65_RS06385	COG3468	outer membrane autotransporter barrel domain protein
ISU65_RS06390	COG3468	outer membrane autotransporter barrel domain protein
ISU65_RS06430	COG2976	Protein conserved in bacteria
ISU65_RS06435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU65_RS06450	COG1645	bacterial-type flagellum-dependent swarming motility
ISU65_RS06460	COG0517	IMP dehydrogenase activity
ISU65_RS06460	COG0516	GMP reductase activity
ISU65_RS06505	COG3328	transposase activity
ISU65_RS06520	COG0351	phosphomethylpyrimidine kinase
ISU65_RS06545	COG0826	peptidase U32
ISU65_RS06550	COG3422	double-strand break repair
ISU65_RS06555	COG0745	RESPONSE REGULATOR receiver
ISU65_RS06595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISU65_RS06605	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU65_RS06610	COG1177	transmembrane transport
ISU65_RS06615	COG0443	Heat shock 70 kDa protein
ISU65_RS06620	COG2239	Acts as a magnesium transporter
ISU65_RS06635	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISU65_RS06645	COG0581	inorganic phosphate transmembrane transporter activity
ISU65_RS06660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU65_RS06665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ISU65_RS06690	COG1393	Belongs to the ArsC family
ISU65_RS06695	COG4783	chaperone-mediated protein folding
ISU65_RS06700	COG0628	permease
ISU65_RS06710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISU65_RS06715	COG2716	regulation of RNA biosynthetic process
ISU65_RS06725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ISU65_RS06740	COG2321	neutral zinc metallopeptidase
ISU65_RS06760	COG1876	peptidase activity
ISU65_RS06770	COG1393	Belongs to the ArsC family
ISU65_RS06785	COG1175	transmembrane transport
ISU65_RS06790	COG3842	ATPase activity
ISU65_RS06800	COG3119	arylsulfatase activity
ISU65_RS06805	COG0641	radical SAM
ISU65_RS06810	COG1988	membrane-bound metal-dependent
ISU65_RS06820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_RS06830	COG2197	response regulator
ISU65_RS06835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_RS06835	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_RS06840	COG3062	negative regulation of establishment of protein localization
ISU65_RS06850	COG3043	anaerobic respiration
ISU65_RS06855	COG3005	denitrification pathway
ISU65_RS06895	COG3111	PFAM Bacterial OB fold (BOF) protein
ISU65_RS06905	COG2837	iron assimilation
ISU65_RS06910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISU65_RS06920	COG4886	Leucine-rich repeat (LRR) protein
ISU65_RS06930	COG2731	YhcH YjgK YiaL family protein
ISU65_RS06935	COG1737	Transcriptional regulator
ISU65_RS06945	COG4150	thiosulfate binding
ISU65_RS06950	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ISU65_RS06955	COG4208	sulfate ABC transporter
ISU65_RS06960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISU65_RS06975	COG0745	RESPONSE REGULATOR receiver
ISU65_RS06980	COG3850	Histidine kinase
ISU65_RS06980	COG5002	protein histidine kinase activity
ISU65_RS06990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ISU65_RS07010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISU65_RS07025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_RS07030	COG0745	RESPONSE REGULATOR receiver
ISU65_RS07035	COG2205	protein histidine kinase activity
ISU65_RS07055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS07065	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ISU65_RS07080	COG3530	Putative quorum-sensing-regulated virulence factor
ISU65_RS07145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISU65_RS07160	COG0667	Aldo Keto reductase
ISU65_RS07185	COG0436	Aminotransferase
ISU65_RS07190	COG3038	cytochrome b561
ISU65_RS07220	COG3381	protein complex oligomerization
ISU65_RS07225	COG3302	dmso reductase anchor subunit
ISU65_RS07230	COG0437	4 iron, 4 sulfur cluster binding
ISU65_RS07235	COG0243	molybdopterin cofactor binding
ISU65_RS07270	COG2951	lytic endotransglycosylase activity
ISU65_RS07330	COG3121	Chaperone
ISU65_RS07335	COG3188	usher protein
ISU65_RS07340	COG3328	transposase activity
ISU65_RS07345	COG3188	usher protein
ISU65_RS07410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISU65_RS07425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISU65_RS07440	COG1169	isochorismate synthase
ISU65_RS07450	COG4575	ribosome binding
ISU65_RS07455	COG0129	dihydroxy-acid dehydratase activity
ISU65_RS07470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU65_RS07475	COG1609	Transcriptional regulator
ISU65_RS07480	COG1649	PFAM Uncharacterised BCR, COG1649
ISU65_RS07495	COG3265	gluconokinase activity
ISU65_RS07500	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS07505	COG2731	YhcH YjgK YiaL family protein
ISU65_RS07520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU65_RS07525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISU65_RS07535	COG0839	Belongs to the complex I subunit 6 family
ISU65_RS07550	COG1034	ATP synthesis coupled electron transport
ISU65_RS07570	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU65_RS07580	COG0583	DNA-binding transcription factor activity
ISU65_RS07585	COG0436	Aminotransferase
ISU65_RS07600	COG0490	domain, Protein
ISU65_RS07600	COG0471	metal ion transport
ISU65_RS07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_RS07625	COG0280	phosphate acetyltransferase
ISU65_RS07625	COG0857	belongs to the CobB CobQ family
ISU65_RS07630	COG1609	Transcriptional regulator
ISU65_RS07645	COG3328	transposase activity
ISU65_RS07650	COG3037	sugar-specific permease SgaT UlaA
ISU65_RS07655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ISU65_RS07660	COG0622	Phosphoesterase
ISU65_RS07670	COG1090	epimerase
ISU65_RS07675	COG4598	ABC transporter
ISU65_RS07680	COG4160	amino acid transport
ISU65_RS07685	COG4215	(ABC) transporter
ISU65_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS07700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ISU65_RS07705	COG1286	toxin biosynthetic process
ISU65_RS07710	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ISU65_RS07715	COG0285	dihydrofolate synthase activity
ISU65_RS07725	COG0586	Pfam SNARE associated Golgi protein
ISU65_RS07735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISU65_RS07750	COG0697	spore germination
ISU65_RS07765	COG1794	racemase activity, acting on amino acids and derivatives
ISU65_RS07770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU65_RS07785	COG3101	peptidyl-lysine hydroxylation
ISU65_RS07790	COG0730	response to heat
ISU65_RS07805	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU65_RS07815	COG2062	phosphohistidine phosphatase, SixA
ISU65_RS07830	COG3691	Protein conserved in bacteria
ISU65_RS07845	COG4235	cytochrome complex assembly
ISU65_RS07845	COG3088	subunit of a heme lyase
ISU65_RS07850	COG3088	subunit of a heme lyase
ISU65_RS07850	COG4235	cytochrome complex assembly
ISU65_RS07855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISU65_RS07860	COG1138	Cytochrome C-type biogenesis protein
ISU65_RS07870	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU65_RS07875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU65_RS07880	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ISU65_RS07900	COG1704	LemA family
ISU65_RS07910	COG2824	Alkylphosphonate utilization operon protein PhnA
ISU65_RS07970	COG1126	abc transporter atp-binding protein
ISU65_RS07975	COG0765	amino acid transport
ISU65_RS07980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS08010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ISU65_RS08030	COG1063	alcohol dehydrogenase
ISU65_RS08035	COG1879	ABC-type sugar transport system periplasmic component
ISU65_RS08040	COG1129	ABC transporter
ISU65_RS08045	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS08050	COG1609	Transcriptional regulator
ISU65_RS08055	COG0583	DNA-binding transcription factor activity
ISU65_RS08060	COG0473	3-isopropylmalate dehydrogenase activity
ISU65_RS08070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISU65_RS08080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_RS08085	COG2831	hemolysin activation secretion protein
ISU65_RS08130	COG3210	domain, Protein
ISU65_RS08140	COG3842	ATPase activity
ISU65_RS08150	COG1609	Transcriptional regulator
ISU65_RS08165	COG0395	ABC-type sugar transport system, permease component
ISU65_RS08170	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ISU65_RS08195	COG0668	transmembrane transport
ISU65_RS08200	COG1518	maintenance of DNA repeat elements
ISU65_RS08205	COG1203	CRISPR-associated helicase, Cas3
ISU65_RS08230	COG0667	Aldo Keto reductase
ISU65_RS08240	COG0477	Major facilitator Superfamily
ISU65_RS08250	COG0583	DNA-binding transcription factor activity
ISU65_RS08255	COG2771	luxR family
ISU65_RS08260	COG3916	Acyl-homoserine-lactone synthase
ISU65_RS08280	COG0628	permease
ISU65_RS08300	COG3328	transposase activity
ISU65_RS08310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ISU65_RS08330	COG3328	transposase activity
ISU65_RS08335	COG1530	ribonuclease E activity
ISU65_RS08340	COG0564	pseudouridine synthase activity
ISU65_RS08345	COG0424	maF-like protein
ISU65_RS08350	COG1399	metal-binding, possibly nucleic acid-binding protein
ISU65_RS08355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISU65_RS08385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU65_RS08395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU65_RS08400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ISU65_RS08410	COG0470	DNA polymerase III
ISU65_RS08415	COG0084	hydrolase, TatD family'
ISU65_RS08420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_RS08420	COG1263	PTS System
ISU65_RS08445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISU65_RS08450	COG0537	adenosine 5'-monophosphoramidase activity
ISU65_RS08455	COG5633	Lipoprotein
ISU65_RS08470	COG1472	Belongs to the glycosyl hydrolase 3 family
ISU65_RS08480	COG1252	NADH dehydrogenase
ISU65_RS08495	COG3328	transposase activity
ISU65_RS08500	COG3134	Outer membrane lipoprotein
ISU65_RS08505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISU65_RS08510	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU65_RS08520	COG4591	ABC-type transport system involved in lipoprotein release permease component
ISU65_RS08525	COG1940	carbohydrate kinase activity
ISU65_RS08545	COG2850	peptidyl-arginine hydroxylation
ISU65_RS08555	COG0745	RESPONSE REGULATOR receiver
ISU65_RS08565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISU65_RS08585	COG1187	pseudouridine synthase activity
ISU65_RS08590	COG0538	isocitrate dehydrogenase activity
ISU65_RS08605	COG0840	transmembrane signaling receptor activity
ISU65_RS08610	COG0702	epimerase
ISU65_RS08615	COG1733	regulation of RNA biosynthetic process
ISU65_RS08640	COG1522	sequence-specific DNA binding
ISU65_RS08655	COG0604	alcohol dehydrogenase
ISU65_RS08655	COG3321	synthase
ISU65_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS08680	COG1285	pathogenesis
ISU65_RS08705	COG1360	Flagellar Motor Protein
ISU65_RS08710	COG0643	Histidine kinase
ISU65_RS08710	COG2198	Histidine kinase
ISU65_RS08715	COG0835	chemotaxis
ISU65_RS08720	COG2271	Major facilitator Superfamily
ISU65_RS08725	COG0251	oxidation-reduction process
ISU65_RS08735	COG2964	Protein conserved in bacteria
ISU65_RS08755	COG0840	transmembrane signaling receptor activity
ISU65_RS08760	COG0840	transmembrane signaling receptor activity
ISU65_RS08765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ISU65_RS08775	COG0745	RESPONSE REGULATOR receiver
ISU65_RS08780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ISU65_RS08785	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU65_RS08790	COG5295	Hep Hag repeat protein
ISU65_RS08800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISU65_RS08855	COG3121	Chaperone
ISU65_RS08875	COG3008	intermembrane lipid transfer
ISU65_RS08880	COG2995	paraquat-inducible protein a
ISU65_RS08885	COG1956	GAF domain-containing protein
ISU65_RS08895	COG0793	Belongs to the peptidase S41A family
ISU65_RS08905	COG3539	Fimbrial protein
ISU65_RS08910	COG3121	Chaperone
ISU65_RS08925	COG3121	Chaperone
ISU65_RS08930	COG2814	Major facilitator Superfamily
ISU65_RS08935	COG0823	Involved in the tonB-independent uptake of proteins
ISU65_RS08945	COG3023	N-Acetylmuramoyl-L-alanine amidase
ISU65_RS08950	COG1823	symporter activity
ISU65_RS08955	COG1988	membrane-bound metal-dependent
ISU65_RS08960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ISU65_RS08965	COG1653	transport
ISU65_RS08975	COG0395	ABC-type sugar transport system, permease component
ISU65_RS08980	COG1175	transmembrane transport
ISU65_RS08990	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS09000	COG1917	Cupin 2, conserved barrel domain protein
ISU65_RS09005	COG3328	transposase activity
ISU65_RS09010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_RS09020	COG3001	Fructosamine kinase
ISU65_RS09030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU65_RS09035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU65_RS09040	COG1121	(ABC) transporter
ISU65_RS09045	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISU65_RS09065	COG4249	Peptidase C14 caspase catalytic subunit p20
ISU65_RS09100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISU65_RS09100	COG0072	phenylalanine-tRNA ligase activity
ISU65_RS09105	COG0776	regulation of translation
ISU65_RS09120	COG0386	Belongs to the glutathione peroxidase family
ISU65_RS09170	COG0791	NLP P60 protein
ISU65_RS09195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISU65_RS09195	COG0574	Belongs to the PEP-utilizing enzyme family
ISU65_RS09205	COG0628	permease
ISU65_RS09210	COG0277	FAD linked oxidase domain protein
ISU65_RS09210	COG0247	lactate metabolic process
ISU65_RS09215	COG2050	protein possibly involved in aromatic compounds catabolism
ISU65_RS09220	COG0316	Belongs to the HesB IscA family
ISU65_RS09225	COG0719	Fe-S assembly protein
ISU65_RS09230	COG0396	ATPase activity
ISU65_RS09235	COG0719	Fe-S assembly protein
ISU65_RS09250	COG1388	LysM domain
ISU65_RS09250	COG1376	ErfK ybiS ycfS ynhG family protein
ISU65_RS09305	COG0307	riboflavin synthase, alpha
ISU65_RS09310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ISU65_RS09315	COG2814	Major facilitator Superfamily
ISU65_RS09320	COG0583	DNA-binding transcription factor activity
ISU65_RS09340	COG0791	NLP P60 protein
ISU65_RS09345	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ISU65_RS09355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISU65_RS09360	COG0346	lactoylglutathione lyase activity
ISU65_RS09370	COG1309	transcriptional regulator
ISU65_RS09375	COG2194	sulfuric ester hydrolase activity
ISU65_RS09385	COG3133	Outer membrane lipoprotein
ISU65_RS09395	COG3895	Periplasmic Protein
ISU65_RS09415	COG0625	glutathione transferase activity
ISU65_RS09430	COG3104	oligopeptide transport
ISU65_RS09435	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU65_RS09435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU65_RS09440	COG4172	Belongs to the ABC transporter superfamily
ISU65_RS09450	COG4171	peptide transport system, permease
ISU65_RS09455	COG4168	peptide transport system, permease
ISU65_RS09460	COG4166	transmembrane transport
ISU65_RS09470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ISU65_RS09475	COG1842	Phage shock protein A
ISU65_RS09485	COG1983	PspC domain protein
ISU65_RS09495	COG3106	COG3106 Predicted ATPase
ISU65_RS09505	COG5654	RES domain protein
ISU65_RS09510	COG5642	Protein of unknown function (DUF2384)
ISU65_RS09525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISU65_RS09530	COG4948	Mandelate Racemase Muconate Lactonizing
ISU65_RS09535	COG2866	Carboxypeptidase
ISU65_RS09540	COG4166	transmembrane transport
ISU65_RS09555	COG0657	acetylesterase activity
ISU65_RS09565	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISU65_RS09565	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISU65_RS09565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISU65_RS09565	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ISU65_RS09575	COG1285	pathogenesis
ISU65_RS09580	COG3042	response to heat
ISU65_RS09585	COG3187	Heat shock protein
ISU65_RS09590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISU65_RS09595	COG2911	Protein conserved in bacteria
ISU65_RS09605	COG3784	Protein of unknown function (DUF1318)
ISU65_RS09610	COG0246	Mannitol dehydrogenase
ISU65_RS09615	COG2390	Transcriptional regulator
ISU65_RS09625	COG1643	Atp-dependent helicase
ISU65_RS09640	COG3591	Belongs to the peptidase S1B family
ISU65_RS09680	COG1012	belongs to the aldehyde dehydrogenase family
ISU65_RS09680	COG1454	alcohol dehydrogenase
ISU65_RS09685	COG2095	MarC family integral membrane protein
ISU65_RS09695	COG0601	transmembrane transport
ISU65_RS09700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_RS09705	COG0444	Belongs to the ABC transporter superfamily
ISU65_RS09710	COG4608	Belongs to the ABC transporter superfamily
ISU65_RS09755	COG2350	Protein conserved in bacteria
ISU65_RS09760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ISU65_RS09765	COG3328	transposase activity
ISU65_RS09800	COG3047	cAMP biosynthetic process
ISU65_RS09820	COG0135	phosphoribosylanthranilate isomerase activity
ISU65_RS09820	COG0134	indole-3-glycerol-phosphate synthase activity
ISU65_RS09830	COG0512	Glutamine amidotransferase of anthranilate synthase
ISU65_RS09850	COG0009	L-threonylcarbamoyladenylate synthase
ISU65_RS09855	COG1187	pseudouridine synthase activity
ISU65_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS09870	COG0616	signal peptide processing
ISU65_RS09890	COG0583	DNA-binding transcription factor activity
ISU65_RS09910	COG0671	phosphoesterase, PA-phosphatase related
ISU65_RS09915	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ISU65_RS09920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ISU65_RS09935	COG0023	Translation Initiation Factor
ISU65_RS09955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISU65_RS09960	COG2879	small protein
ISU65_RS09965	COG1966	Carbon starvation protein
ISU65_RS09975	COG2271	Major facilitator Superfamily
ISU65_RS09980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_RS09985	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISU65_RS09995	COG4659	FMN binding
ISU65_RS10000	COG4658	electron transport chain
ISU65_RS10005	COG3708	Transcriptional regulator
ISU65_RS10005	COG2207	Transcriptional regulator
ISU65_RS10035	COG1132	(ABC) transporter
ISU65_RS10045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_RS10050	COG2274	protein secretion by the type I secretion system
ISU65_RS10065	COG1879	ABC-type sugar transport system periplasmic component
ISU65_RS10070	COG1129	ABC transporter
ISU65_RS10075	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS10085	COG0673	inositol 2-dehydrogenase activity
ISU65_RS10090	COG0385	Bile acid
ISU65_RS10100	COG5339	Protein conserved in bacteria
ISU65_RS10110	COG0114	fumarate hydratase activity
ISU65_RS10120	COG2814	Major facilitator Superfamily
ISU65_RS10125	COG0583	DNA-binding transcription factor activity
ISU65_RS10130	COG1940	carbohydrate kinase activity
ISU65_RS10135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ISU65_RS10140	COG0038	chloride channel
ISU65_RS10145	COG1609	Transcriptional regulator
ISU65_RS10165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU65_RS10175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ISU65_RS10205	COG0028	Belongs to the TPP enzyme family
ISU65_RS10210	COG0440	acetolactate synthase activity
ISU65_RS10215	COG1011	Hydrolase
ISU65_RS10235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU65_RS10240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ISU65_RS10245	COG0589	response to stress
ISU65_RS10250	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ISU65_RS10255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ISU65_RS10265	COG0531	amino acid
ISU65_RS10275	COG0745	RESPONSE REGULATOR receiver
ISU65_RS10280	COG2205	protein histidine kinase activity
ISU65_RS10285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ISU65_RS10320	COG0745	RESPONSE REGULATOR receiver
ISU65_RS10330	COG0788	formyltetrahydrofolate deformylase activity
ISU65_RS10335	COG3328	transposase activity
ISU65_RS10355	COG0583	DNA-binding transcription factor activity
ISU65_RS10360	COG0708	Exodeoxyribonuclease III
ISU65_RS10365	COG0494	nUDIX hydrolase
ISU65_RS10375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISU65_RS10380	COG0709	Synthesizes selenophosphate from selenide and ATP
ISU65_RS10385	COG0778	Nitroreductase
ISU65_RS10390	COG0616	signal peptide processing
ISU65_RS10395	COG0252	asparaginase activity
ISU65_RS10400	COG1335	isochorismatase
ISU65_RS10405	COG3139	Protein of unknown function (DUF1315)
ISU65_RS10425	COG3713	MltA-interacting MipA family protein
ISU65_RS10430	COG2766	serine protein kinase
ISU65_RS10445	COG0583	DNA-binding transcription factor activity
ISU65_RS10455	COG2814	Major facilitator Superfamily
ISU65_RS10465	COG2719	SpoVR family
ISU65_RS10495	COG1104	cysteine desulfurase activity
ISU65_RS10505	COG3328	transposase activity
ISU65_RS10665	COG3328	transposase activity
ISU65_RS10765	COG0582	viral genome integration into host DNA
ISU65_RS10775	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISU65_RS10780	COG2951	lytic endotransglycosylase activity
ISU65_RS10795	COG2894	cell division
ISU65_RS10800	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ISU65_RS10805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ISU65_RS10810	COG0318	PFAM AMP-dependent synthetase and ligase
ISU65_RS10830	COG1199	ATP-dependent helicase activity
ISU65_RS10835	COG0251	oxidation-reduction process
ISU65_RS10850	COG0800	Aldolase
ISU65_RS10855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISU65_RS10860	COG1737	Transcriptional regulator
ISU65_RS10865	COG0469	pyruvate kinase activity
ISU65_RS10875	COG1560	Kdo2-lipid A biosynthetic process
ISU65_RS10880	COG0739	heme binding
ISU65_RS10885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ISU65_RS10895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISU65_RS10920	COG0494	nUDIX hydrolase
ISU65_RS10930	COG1801	Protein of unknown function DUF72
ISU65_RS10935	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ISU65_RS10955	COG3102	Protein conserved in bacteria
ISU65_RS10975	COG0728	peptidoglycan biosynthetic process
ISU65_RS10985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISU65_RS11000	COG3381	protein complex oligomerization
ISU65_RS11015	COG1940	carbohydrate kinase activity
ISU65_RS11020	COG0584	glycerophosphoryl diester phosphodiesterase
ISU65_RS11040	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU65_RS11045	COG3833	ABC-type maltose transport systems, permease component
ISU65_RS11085	COG2890	protein-(glutamine-N5) methyltransferase activity
ISU65_RS11110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISU65_RS11125	COG0012	GTP binding
ISU65_RS11175	COG5002	protein histidine kinase activity
ISU65_RS11220	COG0500	methyltransferase
ISU65_RS11240	COG3328	transposase activity
ISU65_RS11285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_RS11290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU65_RS11295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISU65_RS11310	COG0402	S-adenosylhomocysteine deaminase activity
ISU65_RS11375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU65_RS11385	COG3850	Histidine kinase
ISU65_RS11390	COG0387	Pfam Sodium calcium exchanger
ISU65_RS11395	COG1702	phosphate starvation-inducible protein PhoH
ISU65_RS11410	COG3658	cytochrome
ISU65_RS11415	COG1215	transferase activity, transferring glycosyl groups
ISU65_RS11420	COG0726	polysaccharide deacetylase
ISU65_RS11420	COG1649	PFAM Uncharacterised BCR, COG1649
ISU65_RS11425	COG0457	Tetratricopeptide repeat
ISU65_RS11430	COG0006	proline dipeptidase activity
ISU65_RS11450	COG1136	(ABC) transporter
ISU65_RS11450	COG0577	efflux transmembrane transporter activity
ISU65_RS11475	COG0672	)-iron permease
ISU65_RS11490	COG2066	Belongs to the glutaminase family
ISU65_RS11500	COG1349	DNA-binding transcription factor activity
ISU65_RS11510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISU65_RS11515	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ISU65_RS11530	COG2814	Major facilitator Superfamily
ISU65_RS11555	COG2030	dehydratase
ISU65_RS11560	COG0427	acetyl-CoA hydrolase
ISU65_RS11570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS11570	COG2205	protein histidine kinase activity
ISU65_RS11610	COG3121	Chaperone
ISU65_RS11620	COG0582	viral genome integration into host DNA
ISU65_RS11625	COG1169	isochorismate synthase
ISU65_RS11630	COG2814	Major facilitator Superfamily
ISU65_RS11635	COG1132	(ABC) transporter
ISU65_RS11650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISU65_RS11650	COG3433	isochorismatase activity
ISU65_RS11650	COG2226	methyltransferase
ISU65_RS11670	COG1021	2,3-dihydroxybenzoate-AMP ligase
ISU65_RS11675	COG4771	TonB-dependent receptor
ISU65_RS11735	COG3842	ATPase activity
ISU65_RS11740	COG0395	ABC-type sugar transport system, permease component
ISU65_RS11745	COG1175	transmembrane transport
ISU65_RS11755	COG0673	inositol 2-dehydrogenase activity
ISU65_RS11760	COG2188	Transcriptional regulator
ISU65_RS11885	COG2197	response regulator
ISU65_RS11895	COG3136	membrane protein required for alginate biosynthesis
ISU65_RS11915	COG1113	amino acid transport
ISU65_RS11935	COG2822	iron ion transport
ISU65_RS11940	COG0672	)-iron permease
ISU65_RS11955	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU65_RS11955	COG0506	proline dehydrogenase activity
ISU65_RS11955	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ISU65_RS11970	COG1126	abc transporter atp-binding protein
ISU65_RS11975	COG0765	amino acid transport
ISU65_RS11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS11995	COG1191	sigma factor activity
ISU65_RS12025	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ISU65_RS12030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ISU65_RS12035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISU65_RS12055	COG1677	Flagellar hook-basal body complex protein FliE
ISU65_RS12075	COG1157	protein secretion by the type III secretion system
ISU65_RS12090	COG1580	Controls the rotational direction of flagella during chemotaxis
ISU65_RS12115	COG1987	bacterial-type flagellum assembly
ISU65_RS12135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_RS12140	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS12145	COG1129	ABC transporter
ISU65_RS12155	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS12160	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS12160	COG3347	Dehydrogenase
ISU65_RS12165	COG2390	Transcriptional regulator
ISU65_RS12175	COG1256	bacterial-type flagellum assembly
ISU65_RS12215	COG1558	bacterial-type flagellum-dependent cell motility
ISU65_RS12220	COG1815	bacterial-type flagellum-dependent cell motility
ISU65_RS12230	COG2747	anti-sigma28 factor FlgM
ISU65_RS12235	COG3418	PFAM FlgN family protein
ISU65_RS12260	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU65_RS12265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ISU65_RS12290	COG2372	response to copper ion
ISU65_RS12295	COG1528	Iron-storage protein
ISU65_RS12310	COG1770	oligopeptidase
ISU65_RS12325	COG3141	response to X-ray
ISU65_RS12330	COG0513	Belongs to the DEAD box helicase family
ISU65_RS12355	COG1760	l-serine dehydratase
ISU65_RS12360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISU65_RS12365	COG2368	4-hydroxyphenylacetate
ISU65_RS12380	COG3971	2-oxopent-4-enoate hydratase activity
ISU65_RS12390	COG3384	dioxygenase
ISU65_RS12395	COG1012	belongs to the aldehyde dehydrogenase family
ISU65_RS12410	COG1846	Transcriptional regulator
ISU65_RS12415	COG1253	flavin adenine dinucleotide binding
ISU65_RS12420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS12420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_RS12425	COG3715	PTS system
ISU65_RS12430	COG3716	PTS system mannose fructose sorbose family IID component
ISU65_RS12460	COG2226	methyltransferase
ISU65_RS12465	COG1496	oxidoreductase activity
ISU65_RS12485	COG1113	amino acid transport
ISU65_RS12520	COG2207	Transcriptional regulator
ISU65_RS12530	COG1132	(ABC) transporter
ISU65_RS12575	COG3328	transposase activity
ISU65_RS12580	COG2223	nitrite transmembrane transporter activity
ISU65_RS12600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ISU65_RS12625	COG3122	Protein conserved in bacteria
ISU65_RS12645	COG0534	Mate efflux family protein
ISU65_RS12660	COG4948	Mandelate Racemase Muconate Lactonizing
ISU65_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS12675	COG3011	Protein conserved in bacteria
ISU65_RS12680	COG2271	Major facilitator Superfamily
ISU65_RS12685	COG1470	cell adhesion involved in biofilm formation
ISU65_RS12685	COG1388	LysM domain
ISU65_RS12690	COG3328	transposase activity
ISU65_RS12705	COG2925	Exonuclease
ISU65_RS12715	COG0531	amino acid
ISU65_RS12720	COG0371	Dehydrogenase
ISU65_RS12725	COG1129	ABC transporter
ISU65_RS12730	COG1129	ABC transporter
ISU65_RS12735	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS12750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_RS12765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISU65_RS12775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU65_RS12775	COG0131	Imidazoleglycerol-phosphate dehydratase
ISU65_RS12795	COG0140	phosphoribosyl-ATP diphosphatase activity
ISU65_RS12795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ISU65_RS12805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU65_RS12810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISU65_RS12825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISU65_RS12830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS12835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS12840	COG1120	ATPase activity
ISU65_RS12855	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ISU65_RS12860	COG0076	glutamate decarboxylase activity
ISU65_RS12865	COG4114	ferric iron reductase
ISU65_RS12870	COG1253	flavin adenine dinucleotide binding
ISU65_RS12875	COG2982	Protein involved in outer membrane biogenesis
ISU65_RS12890	COG0489	protein tyrosine kinase activity
ISU65_RS12920	COG2814	Major facilitator Superfamily
ISU65_RS12930	COG1346	cytolysis
ISU65_RS12945	COG2949	membrane
ISU65_RS12950	COG4211	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS12965	COG2311	Membrane
ISU65_RS12975	COG0477	Major facilitator Superfamily
ISU65_RS12980	COG0583	DNA-binding transcription factor activity
ISU65_RS13010	COG1136	(ABC) transporter
ISU65_RS13020	COG0303	'Molybdopterin
ISU65_RS13030	COG3328	transposase activity
ISU65_RS13040	COG0488	(ABC) transporter
ISU65_RS13170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ISU65_RS13175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISU65_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS13190	COG1024	Enoyl-CoA hydratase
ISU65_RS13200	COG3425	synthase
ISU65_RS13205	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS13210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ISU65_RS13215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ISU65_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS13250	COG2920	part of a sulfur-relay system
ISU65_RS13270	COG1832	CoA-binding protein
ISU65_RS13285	COG0210	DNA helicase
ISU65_RS13290	COG3304	Inner membrane component domain
ISU65_RS13295	COG1289	transmembrane transporter activity
ISU65_RS13300	COG3070	regulator of competence-specific genes
ISU65_RS13325	COG1067	ATP-dependent peptidase activity
ISU65_RS13365	COG3130	regulation of translation
ISU65_RS13370	COG3009	Protein conserved in bacteria
ISU65_RS13375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU65_RS13375	COG3008	intermembrane lipid transfer
ISU65_RS13380	COG2995	paraquat-inducible protein a
ISU65_RS13385	COG0488	(ABC) transporter
ISU65_RS13395	COG3217	Mosc domain protein beta barrel domain protein
ISU65_RS13395	COG0633	Ferredoxin
ISU65_RS13410	COG0308	aminopeptidase N
ISU65_RS13430	COG1448	Aminotransferase
ISU65_RS13440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU65_RS13445	COG3108	Peptidase M15
ISU65_RS13450	COG2989	Protein conserved in bacteria
ISU65_RS13475	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ISU65_RS13480	COG3173	Aminoglycoside phosphotransferase
ISU65_RS13495	COG1278	Cold shock
ISU65_RS13500	COG5383	Protein conserved in bacteria
ISU65_RS13515	COG2333	competence protein COMEC
ISU65_RS13515	COG0658	competence protein
ISU65_RS13525	COG0539	negative regulation of cytoplasmic translation
ISU65_RS13550	COG5295	Hep Hag repeat protein
ISU65_RS13550	COG5295	Hep Hag repeat protein
ISU65_RS13555	COG0252	asparaginase activity
ISU65_RS13560	COG1944	ATP diphosphatase activity
ISU65_RS13565	COG2116	formate transmembrane transporter activity
ISU65_RS13570	COG1882	Formate acetyltransferase
ISU65_RS13580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ISU65_RS13610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISU65_RS13620	COG1674	ftsk spoiiie
ISU65_RS13620	COG3107	peptidoglycan biosynthetic process
ISU65_RS13630	COG0492	ferredoxin-NADP+ reductase activity
ISU65_RS13640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ISU65_RS13650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ISU65_RS13660	COG0542	response to heat
ISU65_RS13670	COG1278	Cold shock
ISU65_RS13680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_RS13685	COG2990	Protein conserved in bacteria
ISU65_RS13690	COG3593	DNA synthesis involved in DNA repair
ISU65_RS13695	COG2431	L-lysine efflux transmembrane transporter activity
ISU65_RS13705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_RS13710	COG0028	Belongs to the TPP enzyme family
ISU65_RS13720	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ISU65_RS13725	COG0702	epimerase
ISU65_RS13730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISU65_RS13740	COG1605	Chorismate mutase
ISU65_RS13745	COG1126	abc transporter atp-binding protein
ISU65_RS13750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS13755	COG4215	(ABC) transporter
ISU65_RS13760	COG4160	amino acid transport
ISU65_RS13785	COG1120	ATPase activity
ISU65_RS13790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS13795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS13820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS13835	COG1177	transmembrane transport
ISU65_RS13840	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISU65_RS13845	COG3842	ATPase activity
ISU65_RS13850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISU65_RS13880	COG0671	phosphoesterase, PA-phosphatase related
ISU65_RS13890	COG1349	DNA-binding transcription factor activity
ISU65_RS13895	COG0814	amino acid
ISU65_RS13900	COG1686	Belongs to the peptidase S11 family
ISU65_RS13905	COG2011	ABC-type metal ion transport system permease component
ISU65_RS13930	COG0625	glutathione transferase activity
ISU65_RS13935	COG4771	TonB-dependent receptor
ISU65_RS13945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS13955	COG0833	amino acid
ISU65_RS13960	COG0583	DNA-binding transcription factor activity
ISU65_RS13965	COG2855	membrane
ISU65_RS13975	COG3188	usher protein
ISU65_RS13980	COG3121	Chaperone
ISU65_RS13995	COG3710	Transcriptional regulator
ISU65_RS14000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ISU65_RS14000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_RS14000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISU65_RS14005	COG1105	Belongs to the carbohydrate kinase PfkB family
ISU65_RS14015	COG0494	nUDIX hydrolase
ISU65_RS14025	COG1129	ABC transporter
ISU65_RS14075	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS14100	COG0246	Mannitol dehydrogenase
ISU65_RS14105	COG2186	Transcriptional regulator
ISU65_RS14110	COG0523	cobalamin synthesis protein
ISU65_RS14115	COG0671	phosphoesterase, PA-phosphatase related
ISU65_RS14120	COG0791	NLP P60 protein
ISU65_RS14125	COG2200	EAL domain
ISU65_RS14130	COG4166	transmembrane transport
ISU65_RS14135	COG4174	ABC transporter (Permease)
ISU65_RS14140	COG4239	(ABC) transporter, permease
ISU65_RS14145	COG4172	Belongs to the ABC transporter superfamily
ISU65_RS14155	COG2814	Major facilitator Superfamily
ISU65_RS14160	COG1187	pseudouridine synthase activity
ISU65_RS14165	COG1061	Type III restriction enzyme res subunit
ISU65_RS14185	COG3082	Protein of unknown function (DUF1414)
ISU65_RS14190	COG3083	sulfuric ester hydrolase activity
ISU65_RS14205	COG3157	Type VI secretion system effector, Hcp
ISU65_RS14225	COG2723	6-phospho-beta-galactosidase activity
ISU65_RS14230	COG1737	Transcriptional regulator
ISU65_RS14250	COG3299	homolog of phage Mu protein gp47
ISU65_RS14290	COG4386	tail sheath protein
ISU65_RS14310	COG3622	Belongs to the hyi family
ISU65_RS14315	COG1349	DNA-binding transcription factor activity
ISU65_RS14325	COG3395	kinase activity
ISU65_RS14365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISU65_RS14390	COG2223	nitrite transmembrane transporter activity
ISU65_RS14395	COG0642	Histidine kinase
ISU65_RS14395	COG2198	Histidine kinase
ISU65_RS14400	COG2198	Histidine kinase
ISU65_RS14400	COG0642	Histidine kinase
ISU65_RS14410	COG0784	Response regulator, receiver
ISU65_RS14410	COG2205	protein histidine kinase activity
ISU65_RS14435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISU65_RS14450	COG0814	amino acid
ISU65_RS14475	COG0697	spore germination
ISU65_RS14485	COG1982	Orn Lys Arg decarboxylase major
ISU65_RS14490	COG0531	amino acid
ISU65_RS14495	COG1174	glycine betaine transport
ISU65_RS14500	COG1125	glycine betaine transport
ISU65_RS14505	COG1174	glycine betaine transport
ISU65_RS14515	COG2897	thiosulfate sulfurtransferase activity
ISU65_RS14535	COG1122	ATPase activity
ISU65_RS14555	COG4807	Protein conserved in bacteria
ISU65_RS14570	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ISU65_RS14580	COG2261	transglycosylase associated protein
ISU65_RS14600	COG0277	FAD linked oxidase domain protein
ISU65_RS14605	COG1686	Belongs to the peptidase S11 family
ISU65_RS14615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU65_RS14630	COG0670	Belongs to the BI1 family
ISU65_RS14635	COG0314	molybdopterin synthase activity
ISU65_RS14640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ISU65_RS14650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISU65_RS14655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISU65_RS14660	COG4628	conserved protein (DUF2132)
ISU65_RS14670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISU65_RS14680	COG2226	methyltransferase
ISU65_RS14705	COG0561	phosphatase activity
ISU65_RS14715	COG4149	molybdate abc transporter
ISU65_RS14720	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISU65_RS14730	COG3585	molybdate ion transport
ISU65_RS14730	COG2005	Transcriptional regulator
ISU65_RS14735	COG1119	ATPase activity
ISU65_RS14745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISU65_RS14750	COG1085	galactose-1-phosphate uridylyltransferase
ISU65_RS14765	COG2017	converts alpha-aldose to the beta-anomer
ISU65_RS14780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ISU65_RS14785	COG1230	cation diffusion facilitator family transporter
ISU65_RS14815	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ISU65_RS14820	COG2885	chlorophyll binding
ISU65_RS14830	COG3064	Membrane
ISU65_RS14830	COG3064	Membrane
ISU65_RS14835	COG0848	biopolymer transport protein
ISU65_RS14840	COG0811	peptide transport
ISU65_RS14845	COG0824	Thioesterase
ISU65_RS14850	COG3790	cyd operon protein YbgE
ISU65_RS14855	COG4890	Cyd operon protein YbgT
ISU65_RS14860	COG1294	oxidase, subunit
ISU65_RS14865	COG1271	oxidase subunit
ISU65_RS14870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISU65_RS14880	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISU65_RS14885	COG0567	Dehydrogenase, E1 component
ISU65_RS14895	COG1053	succinate dehydrogenase
ISU65_RS14900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ISU65_RS14905	COG2009	succinate dehydrogenase
ISU65_RS14920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISU65_RS14925	COG0497	DNA recombination
ISU65_RS14930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ISU65_RS14940	COG2867	negative regulation of translational initiation
ISU65_RS14960	COG0582	viral genome integration into host DNA
ISU65_RS15010	COG3657	addiction module killer protein
ISU65_RS15035	COG1953	Uracil, thiamine, allantoin
ISU65_RS15055	COG2226	methyltransferase
ISU65_RS15060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU65_RS15065	COG1388	LysM domain
ISU65_RS15065	COG0741	lytic transglycosylase activity
ISU65_RS15080	COG0656	L-ascorbic acid biosynthetic process
ISU65_RS15110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ISU65_RS15120	COG2011	ABC-type metal ion transport system permease component
ISU65_RS15125	COG1464	Belongs to the NlpA lipoprotein family
ISU65_RS15135	COG1720	tRNA m6t6A37 methyltransferase activity
ISU65_RS15145	COG3015	lipoprotein NlpE involved in copper resistance
ISU65_RS15155	COG4681	YaeQ
ISU65_RS15165	COG4568	rho-dependent transcription termination
ISU65_RS15175	COG0037	tRNA processing
ISU65_RS15180	COG0346	lactoylglutathione lyase activity
ISU65_RS15190	COG0587	DNA-directed DNA polymerase activity
ISU65_RS15215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ISU65_RS15230	COG0750	zinc metalloprotease
ISU65_RS15235	COG0575	Belongs to the CDS family
ISU65_RS15295	COG0564	pseudouridine synthase activity
ISU65_RS15300	COG3098	single-species biofilm formation
ISU65_RS15320	COG1611	Belongs to the LOG family
ISU65_RS15355	COG2944	sequence-specific DNA binding
ISU65_RS15445	COG1695	Transcriptional regulator
ISU65_RS15450	COG0791	NLP P60 protein
ISU65_RS15460	COG1879	ABC-type sugar transport system periplasmic component
ISU65_RS15465	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS15470	COG1129	ABC transporter
ISU65_RS15480	COG2182	Extracellular solute-binding protein
ISU65_RS15485	COG1175	transmembrane transport
ISU65_RS15490	COG3833	ABC-type maltose transport systems, permease component
ISU65_RS15495	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ISU65_RS15500	COG1874	Beta-galactosidase
ISU65_RS15505	COG1263	PTS System
ISU65_RS15505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_RS15525	COG2271	Major facilitator Superfamily
ISU65_RS15550	COG3119	arylsulfatase activity
ISU65_RS15555	COG0641	radical SAM
ISU65_RS15565	COG1028	Short-chain dehydrogenase reductase Sdr
ISU65_RS15575	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS15580	COG3716	PTS system mannose fructose sorbose family IID component
ISU65_RS15585	COG3715	PTS system
ISU65_RS15590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_RS15595	COG2222	sugar isomerase
ISU65_RS15605	COG1349	DNA-binding transcription factor activity
ISU65_RS15610	COG3119	arylsulfatase activity
ISU65_RS15650	COG0288	reversible hydration of carbon dioxide
ISU65_RS15670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISU65_RS15690	COG2165	general secretion pathway protein
ISU65_RS15735	COG0840	transmembrane signaling receptor activity
ISU65_RS15750	COG0583	DNA-binding transcription factor activity
ISU65_RS15755	COG2814	Major facilitator Superfamily
ISU65_RS15760	COG0583	DNA-binding transcription factor activity
ISU65_RS15770	COG1609	Transcriptional regulator
ISU65_RS15800	COG0667	Aldo Keto reductase
ISU65_RS15850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ISU65_RS15860	COG1074	ATP-dependent DNA helicase activity
ISU65_RS15865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISU65_RS15875	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU65_RS15890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ISU65_RS15895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISU65_RS15900	COG2166	iron-sulfur cluster assembly
ISU65_RS15905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISU65_RS15915	COG0583	DNA-binding transcription factor activity
ISU65_RS15920	COG2363	Small membrane protein
ISU65_RS15950	COG4771	TonB-dependent receptor
ISU65_RS15955	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISU65_RS15960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ISU65_RS16005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ISU65_RS16015	COG5001	Diguanylate cyclase
ISU65_RS16025	COG2211	Major facilitator Superfamily
ISU65_RS16075	COG2771	luxR family
ISU65_RS16080	COG3916	Acyl-homoserine-lactone synthase
ISU65_RS16200	COG1982	Orn Lys Arg decarboxylase major
ISU65_RS16205	COG1879	ABC-type sugar transport system periplasmic component
ISU65_RS16210	COG1129	ABC transporter
ISU65_RS16215	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS16220	COG4774	siderophore transport
ISU65_RS16240	COG1194	a g-specific adenine glycosylase
ISU65_RS16250	COG3171	Protein conserved in bacteria
ISU65_RS16270	COG3064	Membrane
ISU65_RS16270	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ISU65_RS16270	COG1073	alpha beta
ISU65_RS16275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISU65_RS16280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ISU65_RS16290	COG0762	integral membrane protein
ISU65_RS16295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISU65_RS16300	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISU65_RS16305	COG2805	Type II/IV secretion system protein
ISU65_RS16315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU65_RS16330	COG0189	ligase activity
ISU65_RS16335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISU65_RS16340	COG2356	endonuclease I
ISU65_RS16355	COG1166	arginine decarboxylase activity
ISU65_RS16370	COG0501	Belongs to the peptidase M48B family
ISU65_RS16375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ISU65_RS16395	COG0191	fructose-bisphosphate aldolase activity
ISU65_RS16430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISU65_RS16440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISU65_RS16460	COG0006	proline dipeptidase activity
ISU65_RS16465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU65_RS16470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISU65_RS16515	COG1272	protein, Hemolysin III
ISU65_RS16540	COG0745	RESPONSE REGULATOR receiver
ISU65_RS16545	COG2205	protein histidine kinase activity
ISU65_RS16550	COG4452	Inner membrane protein CreD
ISU65_RS16555	COG0716	FMN binding
ISU65_RS16560	COG4974	Belongs to the 'phage' integrase family
ISU65_RS16565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ISU65_RS16570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISU65_RS16590	COG0582	viral genome integration into host DNA
ISU65_RS16615	COG0582	viral genome integration into host DNA
ISU65_RS16625	COG0795	lipopolysaccharide-transporting ATPase activity
ISU65_RS16630	COG0795	lipopolysaccharide-transporting ATPase activity
ISU65_RS16640	COG2927	DNA polymerase III (CHI subunit)
ISU65_RS16645	COG0525	valine-tRNA ligase activity
ISU65_RS16655	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ISU65_RS16665	COG2731	YhcH YjgK YiaL family protein
ISU65_RS16675	COG0601	transmembrane transport
ISU65_RS16680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISU65_RS16685	COG0444	Belongs to the ABC transporter superfamily
ISU65_RS16690	COG4608	Belongs to the ABC transporter superfamily
ISU65_RS16705	COG2188	Transcriptional regulator
ISU65_RS16710	COG3624	Phosphonate C-P lyase system protein PhnG
ISU65_RS16715	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ISU65_RS16720	COG3626	phosphonate metabolism
ISU65_RS16725	COG3627	carbon phosphorus lyase activity
ISU65_RS16730	COG4107	phosphonate C-P lyase system protein PhnK
ISU65_RS16735	COG4778	phosphonate C-P lyase system protein PhnL
ISU65_RS16740	COG3454	Phosphonate metabolism
ISU65_RS16745	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ISU65_RS16750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISU65_RS16755	COG0702	epimerase
ISU65_RS16770	COG3842	ATPase activity
ISU65_RS16775	COG0395	ABC-type sugar transport system, permease component
ISU65_RS16780	COG1175	transmembrane transport
ISU65_RS16785	COG1653	transport
ISU65_RS16805	COG3153	acetyltransferase
ISU65_RS16810	COG3154	lipid carrier protein
ISU65_RS16815	COG0826	peptidase U32
ISU65_RS16820	COG0826	peptidase U32
ISU65_RS16830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISU65_RS16840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISU65_RS16860	COG0513	Belongs to the DEAD box helicase family
ISU65_RS16905	COG0195	Participates in both transcription termination and antitermination
ISU65_RS16925	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISU65_RS16935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ISU65_RS16950	COG1534	Rna-binding protein
ISU65_RS16960	COG2027	D-alanyl-D-alanine carboxypeptidase
ISU65_RS16965	COG0745	RESPONSE REGULATOR receiver
ISU65_RS16970	COG0642	Histidine kinase
ISU65_RS16980	COG0697	spore germination
ISU65_RS16995	COG0142	geranyltranstransferase activity
ISU65_RS17005	COG3423	Transcriptional regulator
ISU65_RS17025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISU65_RS17030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ISU65_RS17035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ISU65_RS17040	COG2105	PFAM AIG2 family protein
ISU65_RS17045	COG2911	Protein conserved in bacteria
ISU65_RS17050	COG0729	surface antigen
ISU65_RS17060	COG1253	flavin adenine dinucleotide binding
ISU65_RS17070	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ISU65_RS17080	COG0737	Belongs to the 5'-nucleotidase family
ISU65_RS17090	COG0545	Peptidyl-prolyl cis-trans isomerase
ISU65_RS17095	COG3061	Opacity-associated protein A
ISU65_RS17115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISU65_RS17125	COG0360	Binds together with S18 to 16S ribosomal RNA
ISU65_RS17130	COG1073	alpha beta
ISU65_RS17150	COG3650	response to hydrogen peroxide
ISU65_RS17155	COG1960	acyl-CoA dehydrogenase activity
ISU65_RS17160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU65_RS17165	COG0557	exoribonuclease II activity
ISU65_RS17180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ISU65_RS17185	COG0330	HflC and HflK could
ISU65_RS17190	COG0330	HflC and HflK could
ISU65_RS17195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISU65_RS17215	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISU65_RS17220	COG0802	atpase or kinase
ISU65_RS17225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ISU65_RS17225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISU65_RS17230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISU65_RS17245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ISU65_RS17260	COG1511	domain protein
ISU65_RS17260	COG3264	Mechanosensitive ion channel
ISU65_RS17275	COG1053	succinate dehydrogenase
ISU65_RS17280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISU65_RS17290	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ISU65_RS17335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ISU65_RS17350	COG3383	formate dehydrogenase (NAD+) activity
ISU65_RS17355	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_RS17360	COG0493	'glutamate synthase
ISU65_RS17360	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ISU65_RS17365	COG1309	transcriptional regulator
ISU65_RS17425	COG1454	alcohol dehydrogenase
ISU65_RS17435	COG0629	single-stranded DNA binding
ISU65_RS17440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISU65_RS17445	COG2315	Protein conserved in bacteria
ISU65_RS17450	COG1448	Aminotransferase
ISU65_RS17475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU65_RS17480	COG0735	belongs to the Fur family
ISU65_RS17490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ISU65_RS17530	COG3121	Chaperone
ISU65_RS17590	COG1358	cellular component organization or biogenesis
ISU65_RS17615	COG3721	Heme iron utilization protein
ISU65_RS17620	COG0702	epimerase
ISU65_RS17630	COG4771	TonB-dependent receptor
ISU65_RS17635	COG3720	iron ion transport
ISU65_RS17640	COG4558	Periplasmic binding protein
ISU65_RS17645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISU65_RS17655	COG0626	cystathionine gamma-synthase activity
ISU65_RS17660	COG0814	amino acid
ISU65_RS17665	COG0583	DNA-binding transcription factor activity
ISU65_RS17670	COG0425	Belongs to the sulfur carrier protein TusA family
ISU65_RS17675	COG2391	methyltransferase activity
ISU65_RS17785	COG1301	dicarboxylic acid transport
ISU65_RS17795	COG3162	membrane
ISU65_RS17855	COG0151	Belongs to the GarS family
ISU65_RS17875	COG1515	deoxyribonuclease V activity
ISU65_RS17910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISU65_RS17965	COG0250	Participates in transcription elongation, termination and antitermination
ISU65_RS18025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISU65_RS18055	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ISU65_RS18060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISU65_RS18075	COG1739	Uncharacterized protein family UPF0029
ISU65_RS18100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ISU65_RS18135	COG0805	protein transport
ISU65_RS18145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ISU65_RS18165	COG1322	Protein conserved in bacteria
ISU65_RS18170	COG0586	Pfam SNARE associated Golgi protein
ISU65_RS18175	COG1966	Carbon starvation protein
ISU65_RS18190	COG0412	Dienelactone hydrolase
ISU65_RS18200	COG0583	DNA-binding transcription factor activity
ISU65_RS18205	COG0697	spore germination
ISU65_RS18210	COG0679	Auxin Efflux Carrier
ISU65_RS18215	COG0584	glycerophosphoryl diester phosphodiesterase
ISU65_RS18275	COG0410	ABC transporter
ISU65_RS18285	COG4177	L-phenylalanine transmembrane transporter activity
ISU65_RS18295	COG0683	leucine binding
ISU65_RS18315	COG2177	Part of the ABC transporter FtsEX involved in
ISU65_RS18320	COG2884	Cell division ATP-binding protein ftsE
ISU65_RS18325	COG0552	protein localization to endoplasmic reticulum
ISU65_RS18325	COG0552	protein localization to endoplasmic reticulum
ISU65_RS18330	COG0742	ribosomal rna small subunit methyltransferase
ISU65_RS18335	COG3776	membrane
ISU65_RS18350	COG3714	YhhN family
ISU65_RS18365	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISU65_RS18375	COG0247	lactate metabolic process
ISU65_RS18385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISU65_RS18390	COG0584	glycerophosphoryl diester phosphodiesterase
ISU65_RS18400	COG0561	phosphatase activity
ISU65_RS18405	COG2267	carboxylic ester hydrolase activity
ISU65_RS18410	COG1280	lysine exporter protein (LysE YggA)
ISU65_RS18415	COG1280	lysine exporter protein (LysE YggA)
ISU65_RS18420	COG0514	ATP-dependent DNA helicase (RecQ)
ISU65_RS18425	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ISU65_RS18430	COG2050	protein possibly involved in aromatic compounds catabolism
ISU65_RS18445	COG5564	TIM-barrel signal transduction protein
ISU65_RS18450	COG5441	Belongs to the UPF0261 family
ISU65_RS18460	COG0210	DNA helicase
ISU65_RS18465	COG1011	Hydrolase
ISU65_RS18470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ISU65_RS18475	COG3159	Protein conserved in bacteria
ISU65_RS18495	COG3072	Adenylate cyclase
ISU65_RS18510	COG1587	Uroporphyrinogen-III synthase
ISU65_RS18515	COG2959	enzyme of heme biosynthesis
ISU65_RS18520	COG3071	HemY protein
ISU65_RS18550	COG1113	amino acid transport
ISU65_RS18570	COG2244	polysaccharide biosynthetic process
ISU65_RS18575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISU65_RS18580	COG0456	acetyltransferase
ISU65_RS18585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ISU65_RS18590	COG1088	dTDP-glucose 4,6-dehydratase activity
ISU65_RS18595	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ISU65_RS18600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISU65_RS18605	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ISU65_RS18610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISU65_RS18615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISU65_RS18620	COG3118	belongs to the thioredoxin family
ISU65_RS18645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISU65_RS18655	COG3328	transposase activity
ISU65_RS18665	COG3121	Chaperone
ISU65_RS18680	COG3121	Chaperone
ISU65_RS18715	COG0583	DNA-binding transcription factor activity
ISU65_RS18760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISU65_RS18765	COG3978	acetolactate synthase activity
ISU65_RS18785	COG3085	chromosome segregation
ISU65_RS18795	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS18800	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS18805	COG1129	ABC transporter
ISU65_RS18810	COG1879	ABC-type sugar transport system periplasmic component
ISU65_RS18880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU65_RS18880	COG0678	peroxiredoxin activity
ISU65_RS18885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISU65_RS18910	COG1629	transport
ISU65_RS18925	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISU65_RS18950	COG0527	aspartate kinase activity
ISU65_RS18950	COG0460	homoserine dehydrogenase
ISU65_RS18965	COG4682	membrane
ISU65_RS18975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISU65_RS18980	COG1609	Transcriptional regulator
ISU65_RS18985	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ISU65_RS19000	COG1575	Belongs to the MenA family. Type 1 subfamily
ISU65_RS19110	COG3501	Rhs element vgr protein
ISU65_RS19155	COG3501	Rhs element vgr protein
ISU65_RS19165	COG3209	COG3209 Rhs family protein
ISU65_RS19185	COG0673	inositol 2-dehydrogenase activity
ISU65_RS19190	COG1917	Cupin 2, conserved barrel domain protein
ISU65_RS19190	COG2207	Transcriptional regulator
ISU65_RS19195	COG1869	D-ribose catabolic process
ISU65_RS19200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_RS19205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISU65_RS19210	COG0431	NADPH-dependent FMN reductase
ISU65_RS19215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ISU65_RS19225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ISU65_RS19240	COG3077	Addiction module antitoxin, RelB DinJ family
ISU65_RS19245	COG2252	PERMEase
ISU65_RS19250	COG0025	NhaP-type Na H and K H
ISU65_RS19260	COG1560	Kdo2-lipid A biosynthetic process
ISU65_RS19270	COG1129	ABC transporter
ISU65_RS19275	COG1172	Belongs to the binding-protein-dependent transport system permease family
ISU65_RS19285	COG1069	ribulokinase activity
ISU65_RS19295	COG0625	glutathione transferase activity
ISU65_RS19315	COG1278	Cold shock
ISU65_RS19320	COG1278	Cold shock
ISU65_RS19325	COG3133	Outer membrane lipoprotein
ISU65_RS19330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISU65_RS19340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ISU65_RS19370	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ISU65_RS19375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ISU65_RS19385	COG4145	pantothenate transmembrane transporter activity
ISU65_RS19390	COG3924	membrane
ISU65_RS19400	COG0439	Biotin carboxylase
ISU65_RS19405	COG0511	ligase activity, forming carbon-carbon bonds
ISU65_RS19420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISU65_RS19425	COG0604	alcohol dehydrogenase
ISU65_RS19430	COG2200	EAL domain
ISU65_RS19430	COG2199	diguanylate cyclase activity
ISU65_RS19435	COG1077	Cell shape determining protein MreB Mrl
ISU65_RS19440	COG1792	Involved in formation and maintenance of cell shape
ISU65_RS19445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ISU65_RS19450	COG0424	maF-like protein
ISU65_RS19455	COG1530	ribonuclease E activity
ISU65_RS19460	COG3164	Protein of unknown function
ISU65_RS19465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISU65_RS19470	COG0312	modulator of DNA gyrase
ISU65_RS19520	COG0583	DNA-binding transcription factor activity
ISU65_RS19550	COG2732	(Barnase) inhibitor
ISU65_RS19560	COG0312	modulator of DNA gyrase
ISU65_RS19570	COG3783	Cytochrome b(562)
ISU65_RS19575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISU65_RS19580	COG0366	Alpha amylase catalytic
ISU65_RS19585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISU65_RS19585	COG1263	PTS System
ISU65_RS19590	COG1609	Transcriptional regulator
ISU65_RS19615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISU65_RS19635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ISU65_RS19640	COG1137	ATPase activity
ISU65_RS19645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ISU65_RS19650	COG3117	lipopolysaccharide transmembrane transporter activity
ISU65_RS19655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ISU65_RS19660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISU65_RS19660	COG0517	IMP dehydrogenase activity
ISU65_RS19665	COG0530	calcium, potassium:sodium antiporter activity
ISU65_RS19670	COG1127	ABC transporter
ISU65_RS19675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ISU65_RS19680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ISU65_RS19685	COG2854	intermembrane phospholipid transfer
ISU65_RS19690	COG3113	response to antibiotic
ISU65_RS19695	COG5007	Belongs to the BolA IbaG family
ISU65_RS19705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU65_RS19715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISU65_RS19720	COG3105	Protein conserved in bacteria
ISU65_RS19725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ISU65_RS19745	COG0625	glutathione transferase activity
ISU65_RS19750	COG2969	positive regulation of protein catabolic process
ISU65_RS19760	COG0493	'glutamate synthase
ISU65_RS19765	COG0067	glutamate synthase
ISU65_RS19765	COG0070	glutamate synthase
ISU65_RS19765	COG0069	glutamate synthase activity
ISU65_RS19770	COG1242	4 iron, 4 sulfur cluster binding
ISU65_RS19775	COG0784	Response regulator, receiver
ISU65_RS19775	COG5002	protein histidine kinase activity
ISU65_RS19775	COG2198	Histidine kinase
ISU65_RS19780	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ISU65_RS19790	COG2823	Periplasmic or secreted lipoprotein
ISU65_RS19810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISU65_RS19820	COG1741	Belongs to the pirin family
ISU65_RS19825	COG0583	DNA-binding transcription factor activity
ISU65_RS19855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISU65_RS19860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISU65_RS19865	COG1494	fructose-1,6-bisphosphatase
ISU65_RS19875	COG3152	Membrane
ISU65_RS19890	COG0583	DNA-binding transcription factor activity
ISU65_RS19895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISU65_RS19900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ISU65_RS19905	COG0471	metal ion transport
ISU65_RS19915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ISU65_RS19940	COG3678	ATP-independent chaperone mediated protein folding
ISU65_RS19945	COG0745	RESPONSE REGULATOR receiver
ISU65_RS19950	COG2205	protein histidine kinase activity
ISU65_RS19955	COG2169	Transcriptional regulator
ISU65_RS19955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISU65_RS19960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ISU65_RS19965	COG1045	serine acetyltransferase
ISU65_RS19980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ISU65_RS19985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISU65_RS19995	COG4942	peptidase
ISU65_RS20010	COG0156	8-amino-7-oxononanoate synthase activity
ISU65_RS20020	COG0859	PFAM glycosyl transferase family 9
ISU65_RS20025	COG0859	PFAM glycosyl transferase family 9
ISU65_RS20030	COG1519	Transferase
ISU65_RS20065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISU65_RS20090	COG1561	YicC-like family, N-terminal region
ISU65_RS20095	COG2860	membrane
ISU65_RS20115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISU65_RS20120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISU65_RS20125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ISU65_RS20135	COG0786	glutamate:sodium symporter activity
ISU65_RS20140	COG2233	PERMEase
ISU65_RS20145	COG2982	Protein involved in outer membrane biogenesis
ISU65_RS20150	COG0456	acetyltransferase
ISU65_RS20225	COG1175	transmembrane transport
ISU65_RS20230	COG3833	ABC-type maltose transport systems, permease component
ISU65_RS20245	COG0527	aspartate kinase activity
ISU65_RS20275	COG2224	Isocitrate lyase
ISU65_RS20280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ISU65_RS20320	COG2186	Transcriptional regulator
ISU65_RS20325	COG0477	Major facilitator Superfamily
ISU65_RS20340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISU65_RS20380	COG1522	sequence-specific DNA binding
ISU65_RS20385	COG0716	FMN binding
ISU65_RS20400	COG3312	ion transport
ISU65_RS20455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISU65_RS20460	COG0573	inorganic phosphate transmembrane transporter activity
ISU65_RS20465	COG0581	inorganic phosphate transmembrane transporter activity
ISU65_RS20475	COG0704	Plays a role in the regulation of phosphate uptake
ISU65_RS20485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISU65_RS20490	COG0765	amino acid transport
ISU65_RS20495	COG0765	amino acid transport
ISU65_RS20500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISU65_RS20510	COG2252	PERMEase
ISU65_RS20545	COG0706	membrane insertase activity
ISU65_RS20560	COG0230	Belongs to the bacterial ribosomal protein bL34 family