locus-tag	class	description
CH54_RS00005	COG0116	Belongs to the methyltransferase superfamily
CH54_RS00005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH54_RS00010	COG0488	(ABC) transporter
CH54_RS00015	COG2995	paraquat-inducible protein a
CH54_RS00020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH54_RS00020	COG3008	intermembrane lipid transfer
CH54_RS00025	COG3009	Protein conserved in bacteria
CH54_RS00030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH54_RS00040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH54_RS00045	COG1067	ATP-dependent peptidase activity
CH54_RS00050	COG3120	sequence-specific DNA binding
CH54_RS00060	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH54_RS00065	COG3070	regulator of competence-specific genes
CH54_RS00070	COG1289	transmembrane transporter activity
CH54_RS00075	COG3304	Inner membrane component domain
CH54_RS00080	COG0210	DNA helicase
CH54_RS00095	COG1832	CoA-binding protein
CH54_RS00100	COG3785	DNA binding
CH54_RS00105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH54_RS00115	COG1254	Belongs to the acylphosphatase family
CH54_RS00120	COG2920	part of a sulfur-relay system
CH54_RS00130	COG1518	maintenance of DNA repeat elements
CH54_RS00135	COG1203	CRISPR-associated helicase, Cas3
CH54_RS00165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH54_RS00170	COG0437	4 iron, 4 sulfur cluster binding
CH54_RS00175	COG3301	Polysulphide reductase, NrfD
CH54_RS00180	COG1138	Cytochrome C-type biogenesis protein
CH54_RS00185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH54_RS00190	COG3088	subunit of a heme lyase
CH54_RS00190	COG4235	cytochrome complex assembly
CH54_RS00195	COG4235	cytochrome complex assembly
CH54_RS00210	COG3263	regulation of cellular component size
CH54_RS00225	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH54_RS00230	COG2943	transferase activity, transferring hexosyl groups
CH54_RS00235	COG5645	(Lipo)protein
CH54_RS00255	COG2814	Major facilitator Superfamily
CH54_RS00260	COG2259	Doxx family
CH54_RS00265	COG1560	Kdo2-lipid A biosynthetic process
CH54_RS00280	COG0628	permease
CH54_RS00305	COG0418	dihydroorotase activity
CH54_RS00315	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH54_RS00320	COG1530	ribonuclease E activity
CH54_RS00320	COG1530	ribonuclease E activity
CH54_RS00325	COG0564	pseudouridine synthase activity
CH54_RS00335	COG1399	metal-binding, possibly nucleic acid-binding protein
CH54_RS00340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH54_RS00345	COG0416	fatty acid biosynthetic process
CH54_RS00355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CH54_RS00360	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS00370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH54_RS00375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH54_RS00380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH54_RS00385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH54_RS00390	COG0470	DNA polymerase III
CH54_RS00395	COG0084	hydrolase, TatD family'
CH54_RS00400	COG1263	PTS System
CH54_RS00400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS00420	COG0641	radical SAM
CH54_RS00430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH54_RS00435	COG0537	adenosine 5'-monophosphoramidase activity
CH54_RS00440	COG5633	Lipoprotein
CH54_RS00445	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH54_RS00450	COG0510	thiamine kinase activity
CH54_RS00455	COG1472	Belongs to the glycosyl hydrolase 3 family
CH54_RS00460	COG3150	esterase
CH54_RS00465	COG1252	NADH dehydrogenase
CH54_RS00470	COG3134	Outer membrane lipoprotein
CH54_RS00475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH54_RS00480	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH54_RS00490	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH54_RS00495	COG1940	carbohydrate kinase activity
CH54_RS00510	COG2850	peptidyl-arginine hydroxylation
CH54_RS00520	COG0745	RESPONSE REGULATOR receiver
CH54_RS00530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH54_RS00535	COG2915	High frequency lysogenization protein hflD homolog
CH54_RS00540	COG0482	sulfurtransferase activity
CH54_RS00550	COG1187	pseudouridine synthase activity
CH54_RS00555	COG0538	isocitrate dehydrogenase activity
CH54_RS00580	COG0840	transmembrane signaling receptor activity
CH54_RS00585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH54_RS00595	COG2873	o-acetylhomoserine
CH54_RS00600	COG0702	epimerase
CH54_RS00605	COG1733	regulation of RNA biosynthetic process
CH54_RS00620	COG3755	Protein conserved in bacteria
CH54_RS00630	COG5001	Diguanylate cyclase
CH54_RS00630	COG2203	Gaf domain
CH54_RS00630	COG3706	GGDEF domain
CH54_RS00630	COG4251	negative regulation of phosphorylation
CH54_RS00640	COG1132	(ABC) transporter
CH54_RS00665	COG2207	Transcriptional regulator
CH54_RS00700	COG1113	amino acid transport
CH54_RS00720	COG1496	oxidoreductase activity
CH54_RS00725	COG0768	penicillin binding
CH54_RS00730	COG2226	methyltransferase
CH54_RS00740	COG3447	MASE1 domain protein
CH54_RS00740	COG5001	Diguanylate cyclase
CH54_RS00740	COG5002	protein histidine kinase activity
CH54_RS00750	COG1971	Probably functions as a manganese efflux pump
CH54_RS00755	COG4811	Protein of unknown function (DUF986)
CH54_RS00760	COG3716	PTS system mannose fructose sorbose family IID component
CH54_RS00765	COG3715	PTS system
CH54_RS00770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS00770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS00775	COG1253	flavin adenine dinucleotide binding
CH54_RS00780	COG1760	l-serine dehydratase
CH54_RS00785	COG0494	nUDIX hydrolase
CH54_RS00795	COG3140	Belongs to the UPF0181 family
CH54_RS00800	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH54_RS00805	COG0513	Belongs to the DEAD box helicase family
CH54_RS00810	COG3141	response to X-ray
CH54_RS00815	COG3097	Belongs to the UPF0267 family
CH54_RS00825	COG1770	oligopeptidase
CH54_RS00830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH54_RS00845	COG1528	Iron-storage protein
CH54_RS00850	COG2372	response to copper ion
CH54_RS00855	COG1276	copper resistance
CH54_RS00870	COG2026	Addiction module toxin, RelE StbE family
CH54_RS00875	COG3077	Addiction module antitoxin, RelB DinJ family
CH54_RS00885	COG1187	pseudouridine synthase activity
CH54_RS00890	COG0786	glutamate:sodium symporter activity
CH54_RS00920	COG0668	transmembrane transport
CH54_RS00945	COG2203	Gaf domain
CH54_RS00945	COG5001	Diguanylate cyclase
CH54_RS00945	COG3706	GGDEF domain
CH54_RS00945	COG4251	negative regulation of phosphorylation
CH54_RS00980	COG2814	Major facilitator Superfamily
CH54_RS00990	COG3008	intermembrane lipid transfer
CH54_RS00995	COG2995	paraquat-inducible protein a
CH54_RS01000	COG1956	GAF domain-containing protein
CH54_RS01010	COG0793	Belongs to the peptidase S41A family
CH54_RS01015	COG0501	Belongs to the peptidase M48B family
CH54_RS01025	COG2814	Major facilitator Superfamily
CH54_RS01030	COG0823	Involved in the tonB-independent uptake of proteins
CH54_RS01040	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH54_RS01045	COG1823	symporter activity
CH54_RS01050	COG1988	membrane-bound metal-dependent
CH54_RS01055	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH54_RS01060	COG1653	transport
CH54_RS01065	COG3842	ATPase activity
CH54_RS01070	COG0395	ABC-type sugar transport system, permease component
CH54_RS01075	COG1175	transmembrane transport
CH54_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS01090	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH54_RS01095	COG1917	Cupin 2, conserved barrel domain protein
CH54_RS01100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_RS01110	COG3001	Fructosamine kinase
CH54_RS01115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_RS01120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_RS01125	COG1121	(ABC) transporter
CH54_RS01130	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH54_RS01165	COG1811	Na channel or pump
CH54_RS01170	COG4249	Peptidase C14 caspase catalytic subunit p20
CH54_RS01190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH54_RS01200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH54_RS01220	COG0776	regulation of translation
CH54_RS01225	COG3122	Protein conserved in bacteria
CH54_RS01235	COG4139	cobalamin transport
CH54_RS01240	COG0386	Belongs to the glutathione peroxidase family
CH54_RS01245	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH54_RS01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH54_RS01255	COG0463	Glycosyl transferase, family 2
CH54_RS01260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_RS01260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH54_RS01265	COG0726	polysaccharide deacetylase
CH54_RS01270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CH54_RS01275	COG2076	Multidrug Resistance protein
CH54_RS01280	COG2076	Multidrug Resistance protein
CH54_RS01285	COG0791	NLP P60 protein
CH54_RS01290	COG0095	Lipoate-protein ligase
CH54_RS01300	COG4558	Periplasmic binding protein
CH54_RS01305	COG3720	iron ion transport
CH54_RS01325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH54_RS01330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH54_RS01330	COG0574	Belongs to the PEP-utilizing enzyme family
CH54_RS01335	COG0628	permease
CH54_RS01340	COG0277	FAD linked oxidase domain protein
CH54_RS01340	COG0247	lactate metabolic process
CH54_RS01345	COG2050	protein possibly involved in aromatic compounds catabolism
CH54_RS01350	COG0316	Belongs to the HesB IscA family
CH54_RS01355	COG0719	Fe-S assembly protein
CH54_RS01360	COG0396	ATPase activity
CH54_RS01365	COG0719	Fe-S assembly protein
CH54_RS01375	COG2166	iron-sulfur cluster assembly
CH54_RS01380	COG1388	LysM domain
CH54_RS01380	COG1376	ErfK ybiS ycfS ynhG family protein
CH54_RS01410	COG0534	Mate efflux family protein
CH54_RS01415	COG0307	riboflavin synthase, alpha
CH54_RS01420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH54_RS01425	COG2814	Major facilitator Superfamily
CH54_RS01430	COG0583	DNA-binding transcription factor activity
CH54_RS01435	COG1609	Transcriptional regulator
CH54_RS01445	COG0791	NLP P60 protein
CH54_RS01450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH54_RS01455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH54_RS01460	COG0346	lactoylglutathione lyase activity
CH54_RS01465	COG1902	pentaerythritol trinitrate reductase activity
CH54_RS01470	COG1309	transcriptional regulator
CH54_RS01475	COG2194	sulfuric ester hydrolase activity
CH54_RS01480	COG3313	Fe-S protein
CH54_RS01485	COG4989	oxidoreductase activity
CH54_RS01490	COG1289	transmembrane transporter activity
CH54_RS01495	COG1566	PFAM secretion protein HlyD family protein
CH54_RS01505	COG1846	Transcriptional regulator
CH54_RS01510	COG3133	Outer membrane lipoprotein
CH54_RS01515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH54_RS01520	COG3895	Periplasmic Protein
CH54_RS01530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH54_RS01540	COG0625	glutathione transferase activity
CH54_RS01560	COG3104	oligopeptide transport
CH54_RS01570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH54_RS01570	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH54_RS01580	COG4172	Belongs to the ABC transporter superfamily
CH54_RS01590	COG4171	peptide transport system, permease
CH54_RS01595	COG4168	peptide transport system, permease
CH54_RS01600	COG4166	transmembrane transport
CH54_RS01615	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH54_RS01620	COG1842	Phage shock protein A
CH54_RS01630	COG1983	PspC domain protein
CH54_RS01640	COG3106	COG3106 Predicted ATPase
CH54_RS01645	COG3768	UPF0283 membrane protein
CH54_RS01650	COG5654	RES domain protein
CH54_RS01655	COG5642	Protein of unknown function (DUF2384)
CH54_RS01665	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH54_RS01670	COG4948	Mandelate Racemase Muconate Lactonizing
CH54_RS01675	COG2866	Carboxypeptidase
CH54_RS01680	COG4166	transmembrane transport
CH54_RS01695	COG0598	Magnesium transport protein CorA
CH54_RS01700	COG0037	tRNA processing
CH54_RS01710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_RS01710	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH54_RS01710	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH54_RS01710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH54_RS01720	COG1285	pathogenesis
CH54_RS01725	COG3042	response to heat
CH54_RS01730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH54_RS01735	COG2911	Protein conserved in bacteria
CH54_RS01745	COG3784	Protein of unknown function (DUF1318)
CH54_RS01750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH54_RS01755	COG1643	Atp-dependent helicase
CH54_RS01770	COG3591	Belongs to the peptidase S1B family
CH54_RS01785	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH54_RS01790	COG2205	protein histidine kinase activity
CH54_RS01795	COG0745	RESPONSE REGULATOR receiver
CH54_RS01805	COG0531	amino acid
CH54_RS01820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH54_RS01825	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH54_RS01830	COG0589	response to stress
CH54_RS01835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH54_RS01840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH54_RS01855	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH54_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS01880	COG1011	Hydrolase
CH54_RS01885	COG0440	acetolactate synthase activity
CH54_RS01890	COG0028	Belongs to the TPP enzyme family
CH54_RS01900	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH54_RS01920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH54_RS01945	COG1522	sequence-specific DNA binding
CH54_RS01955	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH54_RS01960	COG0426	domain, Protein
CH54_RS01960	COG1773	rubredoxin
CH54_RS01965	COG3604	Transcriptional regulator
CH54_RS01970	COG0625	glutathione transferase activity
CH54_RS01985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CH54_RS02020	COG0640	Transcriptional regulator
CH54_RS02025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH54_RS02030	COG1393	Belongs to the ArsC family
CH54_RS02040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH54_RS02045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CH54_RS02065	COG4221	oxidoreductase activity
CH54_RS02070	COG1742	UPF0060 membrane protein
CH54_RS02090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH54_RS02095	COG1940	carbohydrate kinase activity
CH54_RS02100	COG0583	DNA-binding transcription factor activity
CH54_RS02105	COG2814	Major facilitator Superfamily
CH54_RS02125	COG0114	fumarate hydratase activity
CH54_RS02135	COG5339	Protein conserved in bacteria
CH54_RS02150	COG1609	Transcriptional regulator
CH54_RS02160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS02160	COG1263	PTS System
CH54_RS02165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH54_RS02170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH54_RS02175	COG0385	Bile acid
CH54_RS02180	COG0673	inositol 2-dehydrogenase activity
CH54_RS02210	COG2160	L-arabinose isomerase activity
CH54_RS02215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH54_RS02235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH54_RS02255	COG4656	Part of a membrane complex involved in electron transport
CH54_RS02260	COG2207	Transcriptional regulator
CH54_RS02260	COG3708	Transcriptional regulator
CH54_RS02265	COG4658	electron transport chain
CH54_RS02270	COG4659	FMN binding
CH54_RS02280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH54_RS02300	COG0243	molybdopterin cofactor binding
CH54_RS02305	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH54_RS02310	COG1966	Carbon starvation protein
CH54_RS02315	COG2879	small protein
CH54_RS02320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH54_RS02325	COG1349	DNA-binding transcription factor activity
CH54_RS02335	COG0235	Class ii aldolase
CH54_RS02345	COG0023	Translation Initiation Factor
CH54_RS02350	COG0284	orotidine-5'-phosphate decarboxylase activity
CH54_RS02365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH54_RS02370	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH54_RS02375	COG0671	phosphoesterase, PA-phosphatase related
CH54_RS02400	COG0583	DNA-binding transcription factor activity
CH54_RS02415	COG0616	signal peptide processing
CH54_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS02425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH54_RS02435	COG1187	pseudouridine synthase activity
CH54_RS02530	COG0009	L-threonylcarbamoyladenylate synthase
CH54_RS02535	COG0613	PHP domain protein
CH54_RS02540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CH54_RS02555	COG0134	indole-3-glycerol-phosphate synthase activity
CH54_RS02555	COG0135	phosphoribosylanthranilate isomerase activity
CH54_RS02560	COG0133	tryptophan synthase activity
CH54_RS02565	COG0159	tryptophan synthase activity
CH54_RS02575	COG3047	cAMP biosynthetic process
CH54_RS02590	COG2917	probably involved in intracellular septation
CH54_RS02600	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH54_RS02605	COG2350	Protein conserved in bacteria
CH54_RS02620	COG2200	EAL domain
CH54_RS02625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH54_RS02630	COG3099	Belongs to the UPF0263 family
CH54_RS02635	COG4608	Belongs to the ABC transporter superfamily
CH54_RS02640	COG0444	Belongs to the ABC transporter superfamily
CH54_RS02645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_RS02665	COG2095	MarC family integral membrane protein
CH54_RS02670	COG1454	alcohol dehydrogenase
CH54_RS02670	COG1012	belongs to the aldehyde dehydrogenase family
CH54_RS02695	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH54_RS02705	COG0745	RESPONSE REGULATOR receiver
CH54_RS02710	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH54_RS02720	COG3012	SEC-C Motif Domain Protein
CH54_RS02725	COG0788	formyltetrahydrofolate deformylase activity
CH54_RS02740	COG0583	DNA-binding transcription factor activity
CH54_RS02745	COG0708	Exodeoxyribonuclease III
CH54_RS02750	COG0494	nUDIX hydrolase
CH54_RS02760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH54_RS02770	COG0778	Nitroreductase
CH54_RS02775	COG0616	signal peptide processing
CH54_RS02780	COG0252	asparaginase activity
CH54_RS02785	COG1335	isochorismatase
CH54_RS02790	COG3139	Protein of unknown function (DUF1315)
CH54_RS02795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH54_RS02810	COG3713	MltA-interacting MipA family protein
CH54_RS02815	COG2766	serine protein kinase
CH54_RS02820	COG2718	Belongs to the UPF0229 family
CH54_RS02830	COG0583	DNA-binding transcription factor activity
CH54_RS02840	COG2199	diguanylate cyclase activity
CH54_RS02840	COG2200	EAL domain
CH54_RS02840	COG2202	Pas domain
CH54_RS02845	COG2814	Major facilitator Superfamily
CH54_RS02850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH54_RS02855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH54_RS02860	COG2719	SpoVR family
CH54_RS02865	COG2186	Transcriptional regulator
CH54_RS02870	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH54_RS02875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH54_RS02890	COG2983	Belongs to the UPF0260 family
CH54_RS02895	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH54_RS02900	COG2951	lytic endotransglycosylase activity
CH54_RS02905	COG3100	YcgL domain-containing protein
CH54_RS02915	COG0850	regulation of cytokinetic process
CH54_RS02920	COG2894	cell division
CH54_RS02925	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH54_RS02930	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH54_RS02935	COG0318	PFAM AMP-dependent synthetase and ligase
CH54_RS02940	COG3065	identical protein binding
CH54_RS02950	COG1199	ATP-dependent helicase activity
CH54_RS02955	COG0251	oxidation-reduction process
CH54_RS02960	COG2076	Multidrug Resistance protein
CH54_RS02965	COG2076	Multidrug Resistance protein
CH54_RS02970	COG0800	Aldolase
CH54_RS02975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH54_RS02980	COG1737	Transcriptional regulator
CH54_RS02985	COG0469	pyruvate kinase activity
CH54_RS02990	COG1560	Kdo2-lipid A biosynthetic process
CH54_RS02995	COG0739	heme binding
CH54_RS03000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH54_RS03005	COG1121	(ABC) transporter
CH54_RS03010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_RS03015	COG3104	oligopeptide transport
CH54_RS03020	COG2255	four-way junction helicase activity
CH54_RS03025	COG0632	four-way junction helicase activity
CH54_RS03030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH54_RS03035	COG0217	transcriptional regulatory protein
CH54_RS03040	COG0494	nUDIX hydrolase
CH54_RS03045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH54_RS03050	COG1335	isochorismatase
CH54_RS03055	COG1801	Protein of unknown function DUF72
CH54_RS03060	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH54_RS03065	COG2226	methyltransferase
CH54_RS03070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH54_RS03075	COG3142	Participates in the control of copper homeostasis
CH54_RS03080	COG3102	Protein conserved in bacteria
CH54_RS03085	COG0018	arginyl-trna synthetase
CH54_RS03090	COG0728	peptidoglycan biosynthetic process
CH54_RS03105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH54_RS03110	COG0477	Major facilitator Superfamily
CH54_RS03120	COG3381	protein complex oligomerization
CH54_RS03125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH54_RS03130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH54_RS03155	COG0659	secondary active sulfate transmembrane transporter activity
CH54_RS03160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CH54_RS03175	COG2890	protein-(glutamine-N5) methyltransferase activity
CH54_RS03180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CH54_RS03185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH54_RS03190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH54_RS03200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH54_RS03210	COG0193	aminoacyl-tRNA hydrolase activity
CH54_RS03220	COG0012	GTP binding
CH54_RS03230	COG4942	peptidase
CH54_RS03240	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH54_RS03245	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH54_RS03250	COG1129	ABC transporter
CH54_RS03265	COG0402	S-adenosylhomocysteine deaminase activity
CH54_RS03275	COG1228	amidohydrolase
CH54_RS03290	COG2988	succinylglutamate desuccinylase activity
CH54_RS03295	COG3724	N-succinylarginine dihydrolase activity
CH54_RS03305	COG3138	arginine N-succinyltransferase
CH54_RS03310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH54_RS03315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_RS03320	COG1271	oxidase subunit
CH54_RS03325	COG1294	oxidase, subunit
CH54_RS03330	COG3850	Histidine kinase
CH54_RS03335	COG0583	DNA-binding transcription factor activity
CH54_RS03345	COG0387	Pfam Sodium calcium exchanger
CH54_RS03350	COG1702	phosphate starvation-inducible protein PhoH
CH54_RS03365	COG3658	cytochrome
CH54_RS03370	COG1215	transferase activity, transferring glycosyl groups
CH54_RS03375	COG0726	polysaccharide deacetylase
CH54_RS03375	COG1649	PFAM Uncharacterised BCR, COG1649
CH54_RS03380	COG0457	Tetratricopeptide repeat
CH54_RS03385	COG0006	proline dipeptidase activity
CH54_RS03390	COG4114	ferric iron reductase
CH54_RS03395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH54_RS03420	COG0577	efflux transmembrane transporter activity
CH54_RS03420	COG1136	(ABC) transporter
CH54_RS03430	COG0577	efflux transmembrane transporter activity
CH54_RS03430	COG1136	(ABC) transporter
CH54_RS03445	COG0672	)-iron permease
CH54_RS03465	COG2066	Belongs to the glutaminase family
CH54_RS03470	COG3622	Belongs to the hyi family
CH54_RS03475	COG0235	Class ii aldolase
CH54_RS03480	COG3395	kinase activity
CH54_RS03485	COG1349	DNA-binding transcription factor activity
CH54_RS03490	COG3290	protein histidine kinase activity
CH54_RS03495	COG4565	transcriptional regulatory protein
CH54_RS03500	COG3493	citrate carrier protein
CH54_RS03540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH54_RS03545	COG0322	excinuclease ABC activity
CH54_RS03550	COG2197	response regulator
CH54_RS03560	COG3136	membrane protein required for alginate biosynthesis
CH54_RS03570	COG0366	Alpha amylase catalytic
CH54_RS03590	COG2246	polysaccharide biosynthetic process
CH54_RS03620	COG1113	amino acid transport
CH54_RS03625	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH54_RS03635	COG3423	Transcriptional regulator
CH54_RS03645	COG0477	Major facilitator Superfamily
CH54_RS03650	COG0655	NAD(P)H dehydrogenase (quinone) activity
CH54_RS03665	COG0672	)-iron permease
CH54_RS03680	COG0506	proline dehydrogenase activity
CH54_RS03680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH54_RS03680	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH54_RS03695	COG1126	abc transporter atp-binding protein
CH54_RS03700	COG0765	amino acid transport
CH54_RS03705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS03710	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH54_RS03720	COG1191	sigma factor activity
CH54_RS03750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH54_RS03755	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CH54_RS03765	COG1677	Flagellar hook-basal body complex protein FliE
CH54_RS03780	COG1317	bacterial-type flagellum organization
CH54_RS03800	COG1580	Controls the rotational direction of flagella during chemotaxis
CH54_RS03820	COG1338	Plays a role in the flagellum-specific transport system
CH54_RS03835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH54_RS03840	COG1256	bacterial-type flagellum assembly
CH54_RS03875	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH54_RS03880	COG1558	bacterial-type flagellum-dependent cell motility
CH54_RS03885	COG1815	bacterial-type flagellum-dependent cell motility
CH54_RS03895	COG2747	anti-sigma28 factor FlgM
CH54_RS03900	COG3418	PFAM FlgN family protein
CH54_RS03910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH54_RS03915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH54_RS03920	COG1404	Belongs to the peptidase S8 family
CH54_RS03920	COG4935	Belongs to the peptidase S8 family
CH54_RS03925	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH54_RS03930	COG0745	RESPONSE REGULATOR receiver
CH54_RS03940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH54_RS03945	COG0840	transmembrane signaling receptor activity
CH54_RS03950	COG0840	transmembrane signaling receptor activity
CH54_RS03955	COG0835	chemotaxis
CH54_RS03960	COG2198	Histidine kinase
CH54_RS03960	COG0643	Histidine kinase
CH54_RS03965	COG1360	Flagellar Motor Protein
CH54_RS03985	COG0589	response to stress
CH54_RS03995	COG1285	pathogenesis
CH54_RS04000	COG0840	transmembrane signaling receptor activity
CH54_RS04015	COG1609	Transcriptional regulator
CH54_RS04020	COG3250	beta-galactosidase activity
CH54_RS04025	COG0604	alcohol dehydrogenase
CH54_RS04025	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS04025	COG3321	synthase
CH54_RS04060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH54_RS04070	COG2453	phosphatase
CH54_RS04070	COG0671	phosphoesterase, PA-phosphatase related
CH54_RS04075	COG2267	carboxylic ester hydrolase activity
CH54_RS04085	COG4589	Belongs to the CDS family
CH54_RS04090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH54_RS04095	COG3121	Chaperone
CH54_RS04115	COG3547	Transposase (IS116 IS110 IS902 family)
CH54_RS04120	COG3228	Belongs to the MtfA family
CH54_RS04155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH54_RS04170	COG0471	metal ion transport
CH54_RS04180	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CH54_RS04180	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CH54_RS04185	COG3051	citrate lyase alpha subunit
CH54_RS04190	COG2301	Belongs to the HpcH HpaI aldolase family
CH54_RS04195	COG3052	prosthetic group binding
CH54_RS04200	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH54_RS04205	COG3290	protein histidine kinase activity
CH54_RS04210	COG4565	transcriptional regulatory protein
CH54_RS04225	COG2271	Major facilitator Superfamily
CH54_RS04230	COG1840	ABC-type Fe3 transport system, periplasmic component
CH54_RS04240	COG3842	ATPase activity
CH54_RS04255	COG1132	(ABC) transporter
CH54_RS04260	COG1132	(ABC) transporter
CH54_RS04260	COG2375	cellular response to nickel ion
CH54_RS04270	COG4171	peptide transport system, permease
CH54_RS04275	COG0601	transmembrane transport
CH54_RS04285	COG4771	TonB-dependent receptor
CH54_RS04295	COG1169	isochorismate synthase
CH54_RS04300	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH54_RS04325	COG2226	methyltransferase
CH54_RS04325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH54_RS04325	COG3433	isochorismatase activity
CH54_RS04340	COG2977	Belongs to the P-Pant transferase superfamily
CH54_RS04350	COG0251	oxidation-reduction process
CH54_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS04365	COG2205	protein histidine kinase activity
CH54_RS04375	COG3121	Chaperone
CH54_RS04390	COG3121	Chaperone
CH54_RS04400	COG0784	Response regulator, receiver
CH54_RS04400	COG0835	chemotaxis
CH54_RS04405	COG0583	DNA-binding transcription factor activity
CH54_RS04420	COG1349	DNA-binding transcription factor activity
CH54_RS04425	COG0561	phosphatase activity
CH54_RS04430	COG0352	thiamine-phosphate diphosphorylase activity
CH54_RS04440	COG0534	Mate efflux family protein
CH54_RS04445	COG0137	argininosuccinate synthase activity
CH54_RS04450	COG2211	Major facilitator Superfamily
CH54_RS04455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CH54_RS04465	COG0583	DNA-binding transcription factor activity
CH54_RS04470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH54_RS04475	COG0406	alpha-ribazole phosphatase activity
CH54_RS04490	COG1492	cobalamin metabolic process
CH54_RS04555	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH54_RS04565	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH54_RS04640	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CH54_RS04650	COG1012	belongs to the aldehyde dehydrogenase family
CH54_RS04660	COG4656	Part of a membrane complex involved in electron transport
CH54_RS04680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CH54_RS04685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH54_RS04685	COG1648	precorrin-2 dehydrogenase activity
CH54_RS04690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH54_RS04705	COG1129	ABC transporter
CH54_RS04710	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_RS04725	COG1289	transmembrane transporter activity
CH54_RS04730	COG1022	Amp-dependent synthetase and ligase
CH54_RS04730	COG3320	Male sterility
CH54_RS04735	COG2925	Exonuclease
CH54_RS04740	COG0531	amino acid
CH54_RS04750	COG0371	Dehydrogenase
CH54_RS04755	COG1129	ABC transporter
CH54_RS04760	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_RS04765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_RS04770	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH54_RS04780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH54_RS04785	COG0131	Imidazoleglycerol-phosphate dehydratase
CH54_RS04785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH54_RS04795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH54_RS04800	COG0107	imidazoleglycerol-phosphate synthase activity
CH54_RS04805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH54_RS04805	COG0140	phosphoribosyl-ATP diphosphatase activity
CH54_RS04815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH54_RS04820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH54_RS04825	COG1253	flavin adenine dinucleotide binding
CH54_RS04830	COG3069	C4-dicarboxylate transmembrane transporter activity
CH54_RS04835	COG2982	Protein involved in outer membrane biogenesis
CH54_RS04840	COG0717	Belongs to the dCTP deaminase family
CH54_RS04845	COG0572	uridine kinase
CH54_RS04850	COG0489	protein tyrosine kinase activity
CH54_RS04855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH54_RS04855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH54_RS04875	COG2814	Major facilitator Superfamily
CH54_RS04880	COG1380	Effector of murein hydrolase LrgA
CH54_RS04885	COG1346	cytolysis
CH54_RS04895	COG0281	malic enzyme
CH54_RS04900	COG2949	membrane
CH54_RS04905	COG0298	carbon dioxide binding
CH54_RS04910	COG0375	protein maturation
CH54_RS04915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_RS04920	COG0651	ATP synthesis coupled electron transport
CH54_RS04925	COG0650	Formate hydrogenlyase subunit 4
CH54_RS04930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH54_RS04935	COG4237	Hydrogenase 4 membrane
CH54_RS04940	COG0651	ATP synthesis coupled electron transport
CH54_RS04945	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH54_RS04945	COG3261	NADH dehydrogenase
CH54_RS04950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_RS04955	COG3260	NADH ubiquinone oxidoreductase 20
CH54_RS04965	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH54_RS04970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_RS04975	COG3383	formate dehydrogenase (NAD+) activity
CH54_RS04980	COG3604	Transcriptional regulator
CH54_RS04985	COG2116	formate transmembrane transporter activity
CH54_RS05010	COG2311	Membrane
CH54_RS05015	COG0302	gtp cyclohydrolase
CH54_RS05020	COG0477	Major facilitator Superfamily
CH54_RS05025	COG0583	DNA-binding transcription factor activity
CH54_RS05055	COG1136	(ABC) transporter
CH54_RS05055	COG0577	efflux transmembrane transporter activity
CH54_RS05065	COG0477	Major facilitator Superfamily
CH54_RS05075	COG0303	'Molybdopterin
CH54_RS05080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH54_RS05085	COG0488	(ABC) transporter
CH54_RS05095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH54_RS05110	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CH54_RS05125	COG4106	trans-aconitate 2-methyltransferase activity
CH54_RS05130	COG0783	Belongs to the Dps family
CH54_RS05135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS05140	COG0765	amino acid transport
CH54_RS05145	COG1126	abc transporter atp-binding protein
CH54_RS05155	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH54_RS05170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH54_RS05175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH54_RS05180	COG1199	ATP-dependent helicase activity
CH54_RS05195	COG0697	spore germination
CH54_RS05210	COG1174	glycine betaine transport
CH54_RS05215	COG1125	glycine betaine transport
CH54_RS05220	COG1174	glycine betaine transport
CH54_RS05225	COG1732	Glycine betaine
CH54_RS05240	COG2897	thiosulfate sulfurtransferase activity
CH54_RS05245	COG4807	Protein conserved in bacteria
CH54_RS05260	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CH54_RS05270	COG2261	transglycosylase associated protein
CH54_RS05290	COG0277	FAD linked oxidase domain protein
CH54_RS05295	COG1686	Belongs to the peptidase S11 family
CH54_RS05305	COG2239	Acts as a magnesium transporter
CH54_RS05315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH54_RS05320	COG0513	Belongs to the DEAD box helicase family
CH54_RS05325	COG1309	transcriptional regulator
CH54_RS05330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS05335	COG1131	(ABC) transporter
CH54_RS05340	COG0842	Transport permease protein
CH54_RS05345	COG0842	Transport permease protein
CH54_RS05350	COG0670	Belongs to the BI1 family
CH54_RS05355	COG0314	molybdopterin synthase activity
CH54_RS05360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH54_RS05365	COG0315	cyclic pyranopterin monophosphate synthase activity
CH54_RS05370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH54_RS05375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH54_RS05380	COG4628	conserved protein (DUF2132)
CH54_RS05385	COG0556	nucleotide-excision repair
CH54_RS05400	COG2226	methyltransferase
CH54_RS05405	COG0156	8-amino-7-oxononanoate synthase activity
CH54_RS05410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH54_RS05420	COG2706	6-phosphogluconolactonase activity
CH54_RS05425	COG0561	phosphatase activity
CH54_RS05435	COG4149	molybdate abc transporter
CH54_RS05440	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH54_RS05450	COG2005	Transcriptional regulator
CH54_RS05450	COG3585	molybdate ion transport
CH54_RS05455	COG1119	ATPase activity
CH54_RS05465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH54_RS05475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH54_RS05480	COG2017	converts alpha-aldose to the beta-anomer
CH54_RS05490	COG0588	phosphoglycerate mutase activity
CH54_RS05495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH54_RS05500	COG1230	cation diffusion facilitator family transporter
CH54_RS05510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CH54_RS05535	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH54_RS05540	COG2885	chlorophyll binding
CH54_RS05545	COG0823	Involved in the tonB-independent uptake of proteins
CH54_RS05550	COG3064	Membrane
CH54_RS05550	COG3064	Membrane
CH54_RS05555	COG0848	biopolymer transport protein
CH54_RS05560	COG0811	peptide transport
CH54_RS05565	COG0824	Thioesterase
CH54_RS05570	COG3790	cyd operon protein YbgE
CH54_RS05575	COG4890	Cyd operon protein YbgT
CH54_RS05580	COG1294	oxidase, subunit
CH54_RS05585	COG1271	oxidase subunit
CH54_RS05590	COG0737	Belongs to the 5'-nucleotidase family
CH54_RS05595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH54_RS05605	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH54_RS05610	COG0567	Dehydrogenase, E1 component
CH54_RS05620	COG1053	succinate dehydrogenase
CH54_RS05625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH54_RS05630	COG2009	succinate dehydrogenase
CH54_RS05640	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CH54_RS05655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH54_RS05660	COG1984	allophanate hydrolase subunit 2
CH54_RS05665	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH54_RS05670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH54_RS05675	COG5212	phosphodiesterase
CH54_RS05685	COG3272	Protein of unknown function (DUF1722)
CH54_RS05700	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CH54_RS05705	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH54_RS05710	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH54_RS05715	COG2205	protein histidine kinase activity
CH54_RS05720	COG0745	RESPONSE REGULATOR receiver
CH54_RS05735	COG0033	Phosphoglucomutase
CH54_RS05740	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH54_RS05745	COG0596	Alpha beta hydrolase
CH54_RS05755	COG0840	transmembrane signaling receptor activity
CH54_RS05765	COG0735	belongs to the Fur family
CH54_RS05785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH54_RS05790	COG2190	(PTS) system
CH54_RS05790	COG1263	PTS System
CH54_RS05790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS05795	COG0363	glucosamine-6-phosphate deaminase activity
CH54_RS05800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH54_RS05805	COG1846	Transcriptional regulator
CH54_RS05805	COG1940	carbohydrate kinase activity
CH54_RS05810	COG0647	UMP catabolic process
CH54_RS05815	COG0367	asparagine synthase
CH54_RS05850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH54_RS05855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH54_RS05860	COG1702	phosphate starvation-inducible protein PhoH
CH54_RS05865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH54_RS05870	COG4535	Mg2 and Co2 transporter CorC
CH54_RS05875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH54_RS05890	COG0765	amino acid transport
CH54_RS05895	COG0765	amino acid transport
CH54_RS05900	COG1126	abc transporter atp-binding protein
CH54_RS05910	COG2888	peptidyl-tyrosine sulfation
CH54_RS05920	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH54_RS05925	COG1466	dna polymerase III delta subunit
CH54_RS05930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH54_RS05935	COG0799	negative regulation of ribosome biogenesis
CH54_RS05945	COG0768	penicillin binding
CH54_RS05950	COG0772	Belongs to the SEDS family
CH54_RS05955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH54_RS05960	COG1686	Belongs to the peptidase S11 family
CH54_RS05965	COG2921	Belongs to the UPF0250 family
CH54_RS05970	COG0321	lipoyl(octanoyl) transferase activity
CH54_RS05975	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH54_RS05980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH54_RS05985	COG3706	GGDEF domain
CH54_RS06000	COG1278	Cold shock
CH54_RS06005	COG2197	response regulator
CH54_RS06030	COG5265	(ABC) transporter
CH54_RS06035	COG2850	peptidyl-arginine hydroxylation
CH54_RS06040	COG2824	Alkylphosphonate utilization operon protein PhnA
CH54_RS06060	COG2723	6-phospho-beta-galactosidase activity
CH54_RS06065	COG1263	PTS System
CH54_RS06065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS06070	COG1609	Transcriptional regulator
CH54_RS06075	COG2353	YceI-like domain
CH54_RS06080	COG3038	cytochrome b561
CH54_RS06095	COG1127	ABC transporter
CH54_RS06100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH54_RS06120	COG0531	amino acid
CH54_RS06125	COG2951	lytic endotransglycosylase activity
CH54_RS06145	COG1280	lysine exporter protein (LysE YggA)
CH54_RS06155	COG0243	molybdopterin cofactor binding
CH54_RS06160	COG0437	4 iron, 4 sulfur cluster binding
CH54_RS06165	COG3302	dmso reductase anchor subunit
CH54_RS06170	COG3381	protein complex oligomerization
CH54_RS06205	COG3038	cytochrome b561
CH54_RS06210	COG0436	Aminotransferase
CH54_RS06225	COG3275	phosphorelay sensor kinase activity
CH54_RS06230	COG3279	Response regulator of the LytR AlgR family
CH54_RS06235	COG2223	nitrite transmembrane transporter activity
CH54_RS06240	COG0837	glucose binding
CH54_RS06250	COG0583	DNA-binding transcription factor activity
CH54_RS06255	COG0667	Aldo Keto reductase
CH54_RS06275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH54_RS06300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH54_RS06330	COG3530	Putative quorum-sensing-regulated virulence factor
CH54_RS06335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH54_RS06355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS06360	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH54_RS06370	COG2205	protein histidine kinase activity
CH54_RS06375	COG0745	RESPONSE REGULATOR receiver
CH54_RS06390	COG4208	sulfate ABC transporter
CH54_RS06395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH54_RS06400	COG4150	thiosulfate binding
CH54_RS06410	COG1737	Transcriptional regulator
CH54_RS06415	COG2731	YhcH YjgK YiaL family protein
CH54_RS06430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH54_RS06435	COG2837	iron assimilation
CH54_RS06445	COG3111	PFAM Bacterial OB fold (BOF) protein
CH54_RS06450	COG0456	acetyltransferase
CH54_RS06455	COG0408	coproporphyrinogen oxidase activity
CH54_RS06460	COG1671	Belongs to the UPF0178 family
CH54_RS06470	COG0494	nUDIX hydrolase
CH54_RS06485	COG3005	denitrification pathway
CH54_RS06490	COG3043	anaerobic respiration
CH54_RS06495	COG0243	molybdopterin cofactor binding
CH54_RS06500	COG3062	negative regulation of establishment of protein localization
CH54_RS06510	COG2197	response regulator
CH54_RS06520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_RS06525	COG3842	ATPase activity
CH54_RS06555	COG1393	Belongs to the ArsC family
CH54_RS06560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH54_RS06565	COG1876	peptidase activity
CH54_RS06575	COG0400	carboxylic ester hydrolase activity
CH54_RS06580	COG1444	tRNA N-acetyltransferase activity
CH54_RS06585	COG2707	UPF0756 membrane protein
CH54_RS06590	COG2321	neutral zinc metallopeptidase
CH54_RS06595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH54_RS06600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH54_RS06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH54_RS06610	COG2716	regulation of RNA biosynthetic process
CH54_RS06615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH54_RS06620	COG0628	permease
CH54_RS06625	COG4783	chaperone-mediated protein folding
CH54_RS06630	COG1393	Belongs to the ArsC family
CH54_RS06635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH54_RS06640	COG2233	PERMEase
CH54_RS06645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH54_RS06650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CH54_RS06655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH54_RS06660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH54_RS06675	COG0581	inorganic phosphate transmembrane transporter activity
CH54_RS06680	COG0573	inorganic phosphate transmembrane transporter activity
CH54_RS06685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH54_RS06700	COG2239	Acts as a magnesium transporter
CH54_RS06705	COG5002	protein histidine kinase activity
CH54_RS06705	COG5001	Diguanylate cyclase
CH54_RS06705	COG3447	MASE1 domain protein
CH54_RS06710	COG0443	Heat shock 70 kDa protein
CH54_RS06720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS06730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_RS06735	COG2205	protein histidine kinase activity
CH54_RS06740	COG0745	RESPONSE REGULATOR receiver
CH54_RS06745	COG3422	double-strand break repair
CH54_RS06750	COG0826	peptidase U32
CH54_RS06755	COG1597	lipid kinase activity
CH54_RS06760	COG3730	PTS system glucitol sorbitol-specific
CH54_RS06775	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS06780	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS06785	COG1349	DNA-binding transcription factor activity
CH54_RS06805	COG0351	phosphomethylpyrimidine kinase
CH54_RS06855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CH54_RS07090	COG0582	viral genome integration into host DNA
CH54_RS07095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH54_RS07095	COG0519	Catalyzes the synthesis of GMP from XMP
CH54_RS07100	COG0516	GMP reductase activity
CH54_RS07100	COG0517	IMP dehydrogenase activity
CH54_RS07105	COG1570	exodeoxyribonuclease VII activity
CH54_RS07110	COG1645	bacterial-type flagellum-dependent swarming motility
CH54_RS07120	COG1160	GTP binding
CH54_RS07125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH54_RS07130	COG2976	Protein conserved in bacteria
CH54_RS07135	COG0124	histidyl-tRNA synthetase
CH54_RS07160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH54_RS07175	COG4953	penicillin-binding protein 1C
CH54_RS07180	COG2373	Large extracellular alpha-helical protein
CH54_RS07200	COG2975	iron-sulfur cluster assembly
CH54_RS07205	COG0633	Ferredoxin
CH54_RS07210	COG0443	Heat shock 70 kDa protein
CH54_RS07215	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH54_RS07225	COG0822	iron-sulfur transferase activity
CH54_RS07235	COG1959	2 iron, 2 sulfur cluster binding
CH54_RS07240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH54_RS07245	COG0483	inositol monophosphate 1-phosphatase activity
CH54_RS07250	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH54_RS07255	COG3683	transport system, periplasmic component
CH54_RS07260	COG3711	transcriptional antiterminator
CH54_RS07265	COG2814	Major facilitator Superfamily
CH54_RS07270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH54_RS07275	COG1017	nitric oxide dioxygenase activity
CH54_RS07275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH54_RS07280	COG2188	Transcriptional regulator
CH54_RS07290	COG0347	Belongs to the P(II) protein family
CH54_RS07295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH54_RS07295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH54_RS07300	COG2204	response regulator
CH54_RS07305	COG3170	Tfp pilus assembly protein FimV
CH54_RS07310	COG2205	protein histidine kinase activity
CH54_RS07320	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH54_RS07335	COG0560	Phosphoserine phosphatase
CH54_RS07345	COG3423	Transcriptional regulator
CH54_RS07355	COG1737	Transcriptional regulator
CH54_RS07360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_RS07365	COG2610	gluconate transmembrane transporter activity
CH54_RS07370	COG0736	holo-[acyl-carrier-protein] synthase activity
CH54_RS07375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH54_RS07380	COG1381	Involved in DNA repair and RecF pathway recombination
CH54_RS07385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH54_RS07400	COG0481	GTPase activity
CH54_RS07410	COG3086	response to oxidative stress
CH54_RS07420	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH54_RS07430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH54_RS07435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH54_RS07440	COG0513	Belongs to the DEAD box helicase family
CH54_RS07445	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH54_RS07450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH54_RS07455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH54_RS07460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH54_RS07465	COG0497	DNA recombination
CH54_RS07470	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH54_RS07480	COG2867	negative regulation of translational initiation
CH54_RS07485	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH54_RS07490	COG0582	viral genome integration into host DNA
CH54_RS07505	COG1061	Type III restriction enzyme res subunit
CH54_RS07530	COG3311	Transcriptional regulator
CH54_RS07565	COG2003	Belongs to the UPF0758 family
CH54_RS07575	COG3394	polysaccharide catabolic process
CH54_RS07580	COG1917	Cupin 2, conserved barrel domain protein
CH54_RS07580	COG2169	Transcriptional regulator
CH54_RS07585	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH54_RS07590	COG2723	6-phospho-beta-galactosidase activity
CH54_RS07595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH54_RS07600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH54_RS07605	COG2133	pyrroloquinoline quinone binding
CH54_RS07610	COG0667	Aldo Keto reductase
CH54_RS07625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH54_RS07635	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH54_RS07640	COG4413	Urea transporter
CH54_RS07645	COG0829	nickel cation binding
CH54_RS07650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH54_RS07660	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CH54_RS07665	COG0804	urea catabolic process
CH54_RS07670	COG0832	Belongs to the urease beta subunit family
CH54_RS07675	COG0831	urea catabolic process
CH54_RS07685	COG1124	(ABC) transporter
CH54_RS07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_RS07705	COG0747	negative chemotaxis
CH54_RS07725	COG1278	Cold shock
CH54_RS07760	COG4575	ribosome binding
CH54_RS07770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH54_RS07775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_RS07780	COG1780	Probably involved in ribonucleotide reductase function
CH54_RS07790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH54_RS07800	COG4176	ABC-type proline glycine betaine transport system permease component
CH54_RS07805	COG2113	Glycine betaine
CH54_RS07815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH54_RS07820	COG0328	RNA-DNA hybrid ribonuclease activity
CH54_RS07825	COG2226	methyltransferase
CH54_RS07830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH54_RS07835	COG0741	lytic transglycosylase activity
CH54_RS07835	COG1388	LysM domain
CH54_RS07840	COG3021	interspecies interaction between organisms
CH54_RS07850	COG2814	Major facilitator Superfamily
CH54_RS07855	COG0583	DNA-binding transcription factor activity
CH54_RS07860	COG0656	L-ascorbic acid biosynthetic process
CH54_RS07890	COG0542	response to heat
CH54_RS07895	COG1496	oxidoreductase activity
CH54_RS07900	COG0564	pseudouridine synthase activity
CH54_RS07905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH54_RS07910	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH54_RS07915	COG0077	Prephenate dehydratase
CH54_RS07915	COG1605	Chorismate mutase
CH54_RS07920	COG0287	Prephenate dehydrogenase
CH54_RS07920	COG1605	Chorismate mutase
CH54_RS07925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH54_RS07930	COG3279	Response regulator of the LytR AlgR family
CH54_RS07935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH54_RS07940	COG3137	Salt-induced outer membrane protein
CH54_RS07945	COG0335	large ribosomal subunit rRNA binding
CH54_RS07950	COG0336	Belongs to the RNA methyltransferase TrmD family
CH54_RS07955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH54_RS07965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH54_RS07970	COG4137	Cytochrome C assembly protein
CH54_RS07975	COG4536	flavin adenine dinucleotide binding
CH54_RS07980	COG1854	S-ribosylhomocysteine lyase activity
CH54_RS07985	COG2918	glutathione biosynthetic process
CH54_RS07990	COG1238	metal cluster binding
CH54_RS07995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_RS08020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH54_RS08025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH54_RS08030	COG2137	regulation of response to DNA damage stimulus
CH54_RS08035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH54_RS08050	COG3381	protein complex oligomerization
CH54_RS08055	COG3302	dmso reductase anchor subunit
CH54_RS08060	COG0437	4 iron, 4 sulfur cluster binding
CH54_RS08065	COG0243	molybdopterin cofactor binding
CH54_RS08070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH54_RS08070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH54_RS08085	COG4177	L-phenylalanine transmembrane transporter activity
CH54_RS08090	COG1137	ATPase activity
CH54_RS08095	COG0410	ABC transporter
CH54_RS08155	COG0640	Transcriptional regulator
CH54_RS08160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH54_RS08170	COG1858	cytochrome C peroxidase
CH54_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS08200	COG1538	Outer membrane efflux protein
CH54_RS08205	COG0577	efflux transmembrane transporter activity
CH54_RS08205	COG1136	(ABC) transporter
CH54_RS08210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS08240	COG3539	Fimbrial protein
CH54_RS08245	COG3539	Fimbrial protein
CH54_RS08255	COG3121	Chaperone
CH54_RS08260	COG3188	usher protein
CH54_RS08285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH54_RS08290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH54_RS08295	COG1388	LysM domain
CH54_RS08295	COG4942	peptidase
CH54_RS08300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH54_RS08305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH54_RS08310	COG0585	pseudouridine synthase activity
CH54_RS08315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CH54_RS08325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH54_RS08335	COG0765	amino acid transport
CH54_RS08350	COG0529	Catalyzes the synthesis of activated sulfate
CH54_RS08355	COG2895	sulfate adenylyltransferase (ATP) activity
CH54_RS08360	COG0175	sulfate reduction
CH54_RS08365	COG1648	precorrin-2 dehydrogenase activity
CH54_RS08365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH54_RS08370	COG2234	aminopeptidase activity
CH54_RS08375	COG0175	sulfate reduction
CH54_RS08380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH54_RS08385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH54_RS08390	COG0720	synthase
CH54_RS08395	COG0602	queuosine metabolic process
CH54_RS08420	COG0148	phosphopyruvate hydratase activity
CH54_RS08425	COG0504	CTP synthase activity
CH54_RS08430	COG3956	TIGRFAM MazG family protein
CH54_RS08435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH54_RS08445	COG2205	protein histidine kinase activity
CH54_RS08445	COG3437	response regulator, receiver
CH54_RS08445	COG3850	Histidine kinase
CH54_RS08445	COG4999	Histidine kinase
CH54_RS08450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH54_RS08455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH54_RS08460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH54_RS08470	COG2860	membrane
CH54_RS08475	COG0316	Belongs to the HesB IscA family
CH54_RS08485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH54_RS08490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_RS08495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH54_RS08500	COG1120	ATPase activity
CH54_RS08505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH54_RS08510	COG1643	Atp-dependent helicase
CH54_RS08515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CH54_RS08520	COG1489	DNA binding
CH54_RS08535	COG0617	tRNA 3'-terminal CCA addition
CH54_RS08540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH54_RS08545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH54_RS08550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH54_RS08555	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH54_RS08560	COG0726	polysaccharide deacetylase
CH54_RS08565	COG0842	Transport permease protein
CH54_RS08570	COG1131	(ABC) transporter
CH54_RS08575	COG0288	reversible hydration of carbon dioxide
CH54_RS08580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH54_RS08590	COG2132	Multicopper oxidase
CH54_RS08600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH54_RS08605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CH54_RS08620	COG0697	spore germination
CH54_RS08625	COG3112	Uncharacterised protein family (UPF0231)
CH54_RS08630	COG1049	propionate catabolic process, 2-methylcitrate cycle
CH54_RS08640	COG4977	sequence-specific DNA binding
CH54_RS08650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_RS08655	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH54_RS08660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH54_RS08665	COG2186	Transcriptional regulator
CH54_RS08670	COG1113	amino acid transport
CH54_RS08675	COG3725	Membrane protein required for beta-lactamase induction
CH54_RS08690	COG4969	Belongs to the N-Me-Phe pilin family
CH54_RS08695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH54_RS08700	COG1459	type II secretion system
CH54_RS08705	COG0516	GMP reductase activity
CH54_RS08720	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH54_RS08725	COG0494	nUDIX hydrolase
CH54_RS08730	COG0653	protein targeting
CH54_RS08750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH54_RS08755	COG0849	cell division
CH54_RS08760	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH54_RS08770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH54_RS08775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH54_RS08780	COG0772	Belongs to the SEDS family
CH54_RS08795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH54_RS08800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH54_RS08805	COG0768	penicillin binding
CH54_RS08810	COG3116	cell division
CH54_RS08815	COG0275	rRNA processing
CH54_RS08820	COG2001	Belongs to the MraZ family
CH54_RS08840	COG0028	Belongs to the TPP enzyme family
CH54_RS08845	COG1022	Amp-dependent synthetase and ligase
CH54_RS08855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH54_RS08860	COG0473	3-isopropylmalate dehydrogenase activity
CH54_RS08865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH54_RS08875	COG3033	Beta-eliminating lyase
CH54_RS08880	COG2814	Major facilitator Superfamily
CH54_RS08885	COG1882	Formate acetyltransferase
CH54_RS08890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH54_RS08895	COG4533	DNA binding
CH54_RS08900	COG4143	(ABC) transporter
CH54_RS08905	COG1178	ABC-type Fe3 transport system permease component
CH54_RS08915	COG0586	Pfam SNARE associated Golgi protein
CH54_RS08920	COG0417	DNA replication proofreading
CH54_RS08925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CH54_RS08930	COG0564	pseudouridine synthase activity
CH54_RS08940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH54_RS08950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CH54_RS08960	COG2967	ApaG domain
CH54_RS08965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH54_RS08980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH54_RS08990	COG2966	Psort location CytoplasmicMembrane, score
CH54_RS08995	COG1280	lysine exporter protein (LysE YggA)
CH54_RS09000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH54_RS09010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH54_RS09015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH54_RS09020	COG1047	Peptidyl-prolyl cis-trans
CH54_RS09025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH54_RS09030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH54_RS09035	COG0196	riboflavin kinase activity
CH54_RS09045	COG0583	DNA-binding transcription factor activity
CH54_RS09050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH54_RS09055	COG0484	heat shock protein binding
CH54_RS09065	COG1584	GPR1 FUN34 yaaH family protein
CH54_RS09075	COG0477	Major facilitator Superfamily
CH54_RS09080	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH54_RS09085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH54_RS09090	COG3022	response to hydroperoxide
CH54_RS09100	COG0083	homoserine kinase activity
CH54_RS09115	COG0745	RESPONSE REGULATOR receiver
CH54_RS09120	COG3045	CreA protein
CH54_RS09125	COG2207	Transcriptional regulator
CH54_RS09125	COG3708	Transcriptional regulator
CH54_RS09135	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH54_RS09140	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH54_RS09145	COG0741	lytic transglycosylase activity
CH54_RS09150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH54_RS09155	COG0488	(ABC) transporter
CH54_RS09165	COG0604	alcohol dehydrogenase
CH54_RS09185	COG0560	Phosphoserine phosphatase
CH54_RS09190	COG3726	membrane protein affecting hemolysin expression
CH54_RS09200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH54_RS09205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH54_RS09215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH54_RS09220	COG0084	hydrolase, TatD family'
CH54_RS09225	COG4667	esterase of the alpha-beta hydrolase superfamily
CH54_RS09230	COG2823	Periplasmic or secreted lipoprotein
CH54_RS09235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH54_RS09240	COG0456	acetyltransferase
CH54_RS09245	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH54_RS09250	COG2813	Specifically methylates the guanine in position
CH54_RS09255	COG0667	Aldo Keto reductase
CH54_RS09260	COG0583	DNA-binding transcription factor activity
CH54_RS09285	COG3284	Transcriptional regulator
CH54_RS09310	COG2192	nodulation
CH54_RS09320	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH54_RS09320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS09320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH54_RS09325	COG1461	Dihydroxyacetone kinase
CH54_RS09330	COG2376	Dihydroxyacetone kinase
CH54_RS09340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_RS09345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS09350	COG2235	arginine
CH54_RS09365	COG0859	PFAM glycosyl transferase family 9
CH54_RS09370	COG1070	Carbohydrate kinase
CH54_RS09375	COG2390	Transcriptional regulator
CH54_RS09380	COG1129	ABC transporter
CH54_RS09385	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_RS09390	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_RS09395	COG1879	ABC-type sugar transport system periplasmic component
CH54_RS09400	COG1830	Aldolase
CH54_RS09405	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH54_RS09445	COG2831	hemolysin activation secretion protein
CH54_RS09450	COG3210	domain, Protein
CH54_RS09460	COG3210	domain, Protein
CH54_RS09480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CH54_RS09495	COG0795	lipopolysaccharide-transporting ATPase activity
CH54_RS09500	COG0795	lipopolysaccharide-transporting ATPase activity
CH54_RS09505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH54_RS09510	COG2927	DNA polymerase III (CHI subunit)
CH54_RS09530	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH54_RS09540	COG2731	YhcH YjgK YiaL family protein
CH54_RS09550	COG0601	transmembrane transport
CH54_RS09555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_RS09560	COG0444	Belongs to the ABC transporter superfamily
CH54_RS09565	COG4608	Belongs to the ABC transporter superfamily
CH54_RS09580	COG2188	Transcriptional regulator
CH54_RS09585	COG3624	Phosphonate C-P lyase system protein PhnG
CH54_RS09590	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CH54_RS09595	COG3626	phosphonate metabolism
CH54_RS09600	COG3627	carbon phosphorus lyase activity
CH54_RS09605	COG4107	phosphonate C-P lyase system protein PhnK
CH54_RS09610	COG4778	phosphonate C-P lyase system protein PhnL
CH54_RS09615	COG3454	Phosphonate metabolism
CH54_RS09620	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CH54_RS09625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CH54_RS09630	COG0702	epimerase
CH54_RS09635	COG3787	Belongs to the UPF0306 family
CH54_RS09645	COG3842	ATPase activity
CH54_RS09650	COG0395	ABC-type sugar transport system, permease component
CH54_RS09655	COG1175	transmembrane transport
CH54_RS09660	COG1653	transport
CH54_RS09675	COG1982	Orn Lys Arg decarboxylase major
CH54_RS09680	COG0531	amino acid
CH54_RS09685	COG2827	Endonuclease containing a URI domain
CH54_RS09690	COG3153	acetyltransferase
CH54_RS09695	COG3154	lipid carrier protein
CH54_RS09700	COG0826	peptidase U32
CH54_RS09705	COG0826	peptidase U32
CH54_RS09710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH54_RS09715	COG0513	Belongs to the DEAD box helicase family
CH54_RS09725	COG1185	polyribonucleotide nucleotidyltransferase activity
CH54_RS09735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH54_RS09740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH54_RS09745	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH54_RS09750	COG0195	Participates in both transcription termination and antitermination
CH54_RS09755	COG0779	Required for maturation of 30S ribosomal subunits
CH54_RS09770	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH54_RS09780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH54_RS09790	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH54_RS09795	COG1534	Rna-binding protein
CH54_RS09805	COG2027	D-alanyl-D-alanine carboxypeptidase
CH54_RS09810	COG0745	RESPONSE REGULATOR receiver
CH54_RS09815	COG0642	Histidine kinase
CH54_RS09820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH54_RS09825	COG0697	spore germination
CH54_RS09840	COG0142	geranyltranstransferase activity
CH54_RS09850	COG3423	Transcriptional regulator
CH54_RS09855	COG0039	L-malate dehydrogenase activity
CH54_RS09860	COG1438	arginine binding
CH54_RS09875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH54_RS09880	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CH54_RS09885	COG0840	transmembrane signaling receptor activity
CH54_RS09890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH54_RS09895	COG2105	PFAM AIG2 family protein
CH54_RS09900	COG2911	Protein conserved in bacteria
CH54_RS09905	COG0729	surface antigen
CH54_RS09910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH54_RS09915	COG1253	flavin adenine dinucleotide binding
CH54_RS09925	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH54_RS09930	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH54_RS09935	COG0737	Belongs to the 5'-nucleotidase family
CH54_RS09945	COG0545	Peptidyl-prolyl cis-trans isomerase
CH54_RS09950	COG3061	Opacity-associated protein A
CH54_RS09960	COG0359	binds to the 23S rRNA
CH54_RS09965	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH54_RS09970	COG2965	DNA replication, synthesis of RNA primer
CH54_RS09975	COG0360	Binds together with S18 to 16S ribosomal RNA
CH54_RS09985	COG1073	alpha beta
CH54_RS09990	COG3650	response to hydrogen peroxide
CH54_RS09995	COG1960	acyl-CoA dehydrogenase activity
CH54_RS10000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH54_RS10005	COG0557	exoribonuclease II activity
CH54_RS10010	COG1959	2 iron, 2 sulfur cluster binding
CH54_RS10015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH54_RS10020	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH54_RS10025	COG0330	HflC and HflK could
CH54_RS10030	COG0330	HflC and HflK could
CH54_RS10035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH54_RS10045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH54_RS10050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH54_RS10055	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH54_RS10060	COG0802	atpase or kinase
CH54_RS10065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH54_RS10065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH54_RS10070	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH54_RS10095	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH54_RS10100	COG1162	GTPase activity
CH54_RS10105	COG0688	phosphatidylethanolamine metabolic process
CH54_RS10110	COG1511	domain protein
CH54_RS10110	COG3264	Mechanosensitive ion channel
CH54_RS10115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CH54_RS10120	COG1053	succinate dehydrogenase
CH54_RS10125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH54_RS10130	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH54_RS10135	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH54_RS10155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH54_RS10170	COG0459	protein refolding
CH54_RS10175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH54_RS10190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH54_RS10200	COG4232	protein-disulfide reductase activity
CH54_RS10205	COG3383	formate dehydrogenase (NAD+) activity
CH54_RS10210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_RS10215	COG0493	'glutamate synthase
CH54_RS10215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH54_RS10220	COG2271	Major facilitator Superfamily
CH54_RS10225	COG2721	sulfolactate sulfo-lyase activity
CH54_RS10230	COG3835	regulator
CH54_RS10235	COG1929	Belongs to the glycerate kinase type-1 family
CH54_RS10240	COG2084	Dehydrogenase
CH54_RS10250	COG1309	transcriptional regulator
CH54_RS10260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH54_RS10280	COG2826	transposase and inactivated derivatives, IS30 family
CH54_RS10290	COG0210	DNA helicase
CH54_RS10295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH54_RS10370	COG3657	addiction module killer protein
CH54_RS10640	COG3720	iron ion transport
CH54_RS10645	COG4558	Periplasmic binding protein
CH54_RS10650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_RS10655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH54_RS10660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_RS10670	COG4774	siderophore transport
CH54_RS10675	COG1511	domain protein
CH54_RS10675	COG3264	Mechanosensitive ion channel
CH54_RS10680	COG0425	Belongs to the sulfur carrier protein TusA family
CH54_RS10685	COG2391	methyltransferase activity
CH54_RS10850	COG1301	dicarboxylic acid transport
CH54_RS10855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH54_RS10860	COG3162	membrane
CH54_RS10865	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH54_RS10895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH54_RS10900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH54_RS10905	COG0009	L-threonylcarbamoyladenylate synthase
CH54_RS10910	COG0551	DNA topoisomerase type I activity
CH54_RS10920	COG0758	DNA mediated transformation
CH54_RS10925	COG0242	peptide deformylase activity
CH54_RS10930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH54_RS10935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH54_RS10935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH54_RS10945	COG1970	mechanosensitive ion channel activity
CH54_RS10950	COG3036	rescue of stalled ribosome
CH54_RS10955	COG0789	Transcriptional regulator
CH54_RS10965	COG0203	ribosomal protein L17
CH54_RS10970	COG0202	RNA polymerase activity
CH54_RS10975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH54_RS10980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CH54_RS10985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH54_RS10990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH54_RS10995	COG0201	protein transport
CH54_RS11000	COG0200	Binds to the 23S rRNA
CH54_RS11005	COG1841	ribosomal large subunit assembly
CH54_RS11015	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CH54_RS11020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CH54_RS11030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH54_RS11040	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CH54_RS11045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH54_RS11050	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH54_RS11055	COG0255	Belongs to the universal ribosomal protein uL29 family
CH54_RS11060	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH54_RS11065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH54_RS11070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH54_RS11075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH54_RS11080	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH54_RS11085	COG0089	rRNA binding
CH54_RS11095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH54_RS11100	COG0051	transcription antitermination factor activity, RNA binding
CH54_RS11115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH54_RS11125	COG0049	tRNA binding
CH54_RS11130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH54_RS11135	COG2168	tRNA wobble position uridine thiolation
CH54_RS11140	COG2923	Belongs to the DsrF TusC family
CH54_RS11145	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH54_RS11150	COG2964	Protein conserved in bacteria
CH54_RS11155	COG0545	Peptidyl-prolyl cis-trans isomerase
CH54_RS11160	COG2900	Belongs to the SlyX family
CH54_RS11165	COG1047	Peptidyl-prolyl cis-trans
CH54_RS11170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH54_RS11180	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH54_RS11185	COG0488	(ABC) transporter
CH54_RS11200	COG2175	clavaminate synthase activity
CH54_RS11205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH54_RS11215	COG4521	taurine ABC transporter
CH54_RS11230	COG0429	hydrolase of the alpha beta-hydrolase fold
CH54_RS11235	COG3089	Belongs to the UPF0270 family
CH54_RS11240	COG3954	Phosphoribulokinase
CH54_RS11245	COG1765	OsmC-like protein
CH54_RS11255	COG1289	transmembrane transporter activity
CH54_RS11275	COG0433	COG0433 Predicted ATPase
CH54_RS11280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH54_RS11285	COG1486	melibiose metabolic process
CH54_RS11290	COG1609	Transcriptional regulator
CH54_RS11295	COG0738	Major facilitator superfamily
CH54_RS11300	COG0402	S-adenosylhomocysteine deaminase activity
CH54_RS11305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH54_RS11320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH54_RS11320	COG1648	precorrin-2 dehydrogenase activity
CH54_RS11325	COG0180	Tryptophanyl-tRNA synthetase
CH54_RS11335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH54_RS11355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH54_RS11360	COG4796	Type ii and iii secretion system protein
CH54_RS11385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH54_RS11390	COG0494	nUDIX hydrolase
CH54_RS11400	COG1011	Hydrolase
CH54_RS11405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH54_RS11415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH54_RS11430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH54_RS11455	COG2183	response to ionizing radiation
CH54_RS11460	COG1918	ferrous iron import across plasma membrane
CH54_RS11465	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CH54_RS11480	COG0596	Alpha beta hydrolase
CH54_RS11490	COG0316	Belongs to the HesB IscA family
CH54_RS11490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH54_RS11495	COG1640	4-alpha-glucanotransferase
CH54_RS11500	COG0058	SHG alpha-glucan phosphorylase activity
CH54_RS11505	COG2909	trisaccharide binding
CH54_RS11515	COG0705	Rhomboid family
CH54_RS11520	COG1349	DNA-binding transcription factor activity
CH54_RS11530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH54_RS11535	COG0058	SHG alpha-glucan phosphorylase activity
CH54_RS11540	COG0297	glycogen (starch) synthase activity
CH54_RS11550	COG1523	belongs to the glycosyl hydrolase 13 family
CH54_RS11555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH54_RS11560	COG3275	phosphorelay sensor kinase activity
CH54_RS11585	COG0463	Glycosyl transferase, family 2
CH54_RS11600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH54_RS11605	COG2095	MarC family integral membrane protein
CH54_RS11610	COG3265	gluconokinase activity
CH54_RS11615	COG2610	gluconate transmembrane transporter activity
CH54_RS11620	COG1609	Transcriptional regulator
CH54_RS11625	COG1741	Belongs to the pirin family
CH54_RS11630	COG1247	-acetyltransferase
CH54_RS11635	COG1082	Xylose isomerase domain protein TIM barrel
CH54_RS11640	COG1082	Xylose isomerase domain protein TIM barrel
CH54_RS11645	COG0673	inositol 2-dehydrogenase activity
CH54_RS11650	COG3962	Belongs to the TPP enzyme family
CH54_RS11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_RS11665	COG3718	enzyme involved in inositol metabolism
CH54_RS11725	COG2081	HI0933 family
CH54_RS11730	COG0306	phosphate transporter
CH54_RS11740	COG0589	response to stress
CH54_RS11755	COG0742	ribosomal rna small subunit methyltransferase
CH54_RS11765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH54_RS11770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_RS11780	COG2134	cdp-diacylglycerol pyrophosphatase
CH54_RS11785	COG2982	Protein involved in outer membrane biogenesis
CH54_RS11790	COG2200	EAL domain
CH54_RS11795	COG1942	4-Oxalocrotonate Tautomerase
CH54_RS11800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_RS11805	COG0612	Peptidase, M16
CH54_RS11810	COG1301	dicarboxylic acid transport
CH54_RS11820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH54_RS11825	COG2199	diguanylate cyclase activity
CH54_RS11825	COG2200	EAL domain
CH54_RS11830	COG0457	Tetratricopeptide repeat
CH54_RS11830	COG3118	belongs to the thioredoxin family
CH54_RS11835	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CH54_RS11840	COG1215	transferase activity, transferring glycosyl groups
CH54_RS11845	COG1215	transferase activity, transferring glycosyl groups
CH54_RS11850	COG1192	Involved in chromosome partitioning
CH54_RS11870	COG2194	sulfuric ester hydrolase activity
CH54_RS11875	COG4608	Belongs to the ABC transporter superfamily
CH54_RS11880	COG0444	Belongs to the ABC transporter superfamily
CH54_RS11885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH54_RS11890	COG0601	transmembrane transport
CH54_RS11895	COG0747	negative chemotaxis
CH54_RS11900	COG3210	domain, Protein
CH54_RS11905	COG2831	hemolysin activation secretion protein
CH54_RS11920	COG2271	Major facilitator Superfamily
CH54_RS11925	COG3851	Histidine kinase
CH54_RS11930	COG2197	response regulator
CH54_RS11935	COG2194	sulfuric ester hydrolase activity
CH54_RS11940	COG1764	response to oxidative stress
CH54_RS11960	COG2986	histidine ammonia-lyase
CH54_RS11965	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH54_RS11990	COG2205	protein histidine kinase activity
CH54_RS11990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS11995	COG2207	Transcriptional regulator
CH54_RS11995	COG1609	Transcriptional regulator
CH54_RS12000	COG4214	carbohydrate transport
CH54_RS12010	COG4213	ABC transporter substrate-binding protein
CH54_RS12015	COG2115	Belongs to the xylose isomerase family
CH54_RS12020	COG1070	Carbohydrate kinase
CH54_RS12025	COG3121	Chaperone
CH54_RS12030	COG1335	isochorismatase
CH54_RS12040	COG3274	enterobacterial common antigen metabolic process
CH54_RS12050	COG3550	peptidyl-serine autophosphorylation
CH54_RS12060	COG3276	selenocysteine insertion sequence binding
CH54_RS12065	COG1921	L-seryl-tRNASec selenium transferase activity
CH54_RS12070	COG3058	Necessary for formate dehydrogenase activity
CH54_RS12075	COG2864	formate dehydrogenase
CH54_RS12080	COG0437	4 iron, 4 sulfur cluster binding
CH54_RS12095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH54_RS12100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH54_RS12105	COG0840	transmembrane signaling receptor activity
CH54_RS12120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_RS12130	COG3722	fumarate hydratase activity
CH54_RS12135	COG0246	Mannitol dehydrogenase
CH54_RS12140	COG2213	PTS system mannitol-specific
CH54_RS12140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS12150	COG0751	glycine-tRNA ligase activity
CH54_RS12155	COG0752	glycyl-tRNA synthetase alpha subunit
CH54_RS12160	COG2818	Glycosylase
CH54_RS12165	COG0456	acetyltransferase
CH54_RS12190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH54_RS12195	COG0366	Alpha amylase catalytic
CH54_RS12200	COG3977	Valine--pyruvate aminotransferase
CH54_RS12205	COG2985	domain, Protein
CH54_RS12205	COG0569	domain protein
CH54_RS12220	COG5645	(Lipo)protein
CH54_RS12225	COG0823	Involved in the tonB-independent uptake of proteins
CH54_RS12240	COG2423	ornithine cyclodeaminase activity
CH54_RS12245	COG0561	phosphatase activity
CH54_RS12250	COG0187	DNA topoisomerase II activity
CH54_RS12255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH54_RS12260	COG0592	DNA-directed DNA polymerase activity
CH54_RS12265	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH54_RS12270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH54_RS12275	COG0594	ribonuclease P activity
CH54_RS12280	COG0706	membrane insertase activity
CH54_RS12285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH54_RS12290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH54_RS12305	COG2011	ABC-type metal ion transport system permease component
CH54_RS12310	COG0840	transmembrane signaling receptor activity
CH54_RS12315	COG0431	NADPH-dependent FMN reductase
CH54_RS12320	COG4191	Histidine kinase
CH54_RS12325	COG4566	intracellular signal transduction
CH54_RS12335	COG2252	PERMEase
CH54_RS12340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_RS12345	COG0765	amino acid transport
CH54_RS12350	COG0765	amino acid transport
CH54_RS12355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS12365	COG0704	Plays a role in the regulation of phosphate uptake
CH54_RS12375	COG0581	inorganic phosphate transmembrane transporter activity
CH54_RS12380	COG0573	inorganic phosphate transmembrane transporter activity
CH54_RS12385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH54_RS12390	COG0659	secondary active sulfate transmembrane transporter activity
CH54_RS12400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH54_RS12405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH54_RS12410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH54_RS12420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH54_RS12425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CH54_RS12430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH54_RS12440	COG0356	it plays a direct role in the translocation of protons across the membrane
CH54_RS12445	COG3312	ion transport
CH54_RS12450	COG0357	Ribosomal RNA small subunit methyltransferase G
CH54_RS12455	COG0445	tRNA wobble uridine modification
CH54_RS12460	COG0716	FMN binding
CH54_RS12465	COG1522	sequence-specific DNA binding
CH54_RS12470	COG2502	aspartate--ammonia ligase
CH54_RS12480	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH54_RS12485	COG0714	Associated with various cellular activities
CH54_RS12490	COG3158	transport of potassium into the cell
CH54_RS12495	COG1869	D-ribose catabolic process
CH54_RS12505	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH54_RS12510	COG1879	ABC-type sugar transport system periplasmic component
CH54_RS12515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_RS12520	COG1609	Transcriptional regulator
CH54_RS12525	COG0477	Major facilitator Superfamily
CH54_RS12530	COG2186	Transcriptional regulator
CH54_RS12555	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH54_RS12565	COG3084	Protein conserved in bacteria
CH54_RS12570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH54_RS12575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH54_RS12580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH54_RS12580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH54_RS12585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CH54_RS12590	COG3078	GTPase activator activity
CH54_RS12595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH54_RS12605	COG3852	Histidine kinase
CH54_RS12620	COG1011	Hydrolase
CH54_RS12625	COG1295	ribonuclease BN
CH54_RS12630	COG1490	D-aminoacyl-tRNA deacylase activity
CH54_RS12635	COG0456	acetyltransferase
CH54_RS12640	COG3423	Transcriptional regulator
CH54_RS12655	COG2982	Protein involved in outer membrane biogenesis
CH54_RS12660	COG2233	PERMEase
CH54_RS12665	COG0786	glutamate:sodium symporter activity
CH54_RS12670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH54_RS12675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH54_RS12680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH54_RS12685	COG1758	RNA polymerase activity
CH54_RS12695	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH54_RS12700	COG2860	membrane
CH54_RS12710	COG1024	Enoyl-CoA hydratase
CH54_RS12715	COG5001	Diguanylate cyclase
CH54_RS12740	COG1561	YicC-like family, N-terminal region
CH54_RS12890	COG4695	Portal protein
CH54_RS12935	COG2176	DNA-directed DNA polymerase activity
CH54_RS12935	COG5002	protein histidine kinase activity
CH54_RS12975	COG4974	Belongs to the 'phage' integrase family
CH54_RS12985	COG1309	transcriptional regulator
CH54_RS12990	COG0756	dUTP diphosphatase activity
CH54_RS12995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH54_RS13000	COG2003	Belongs to the UPF0758 family
CH54_RS13005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH54_RS13010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH54_RS13015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH54_RS13030	COG1519	Transferase
CH54_RS13035	COG0859	PFAM glycosyl transferase family 9
CH54_RS13040	COG0859	PFAM glycosyl transferase family 9
CH54_RS13045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_RS13050	COG0156	8-amino-7-oxononanoate synthase activity
CH54_RS13055	COG1063	alcohol dehydrogenase
CH54_RS13065	COG2861	carbohydrate metabolic process
CH54_RS13070	COG4942	peptidase
CH54_RS13075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH54_RS13080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH54_RS13085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_RS13095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH54_RS13100	COG1045	serine acetyltransferase
CH54_RS13105	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH54_RS13110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH54_RS13110	COG2169	Transcriptional regulator
CH54_RS13115	COG2205	protein histidine kinase activity
CH54_RS13120	COG0745	RESPONSE REGULATOR receiver
CH54_RS13125	COG3678	ATP-independent chaperone mediated protein folding
CH54_RS13130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH54_RS13140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH54_RS13160	COG3152	Membrane
CH54_RS13170	COG2814	Major facilitator Superfamily
CH54_RS13175	COG1494	fructose-1,6-bisphosphatase
CH54_RS13180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH54_RS13185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH54_RS13190	COG3074	FtsZ-dependent cytokinesis
CH54_RS13195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH54_RS13200	COG1575	Belongs to the MenA family. Type 1 subfamily
CH54_RS13205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH54_RS13210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH54_RS13215	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH54_RS13220	COG1609	Transcriptional regulator
CH54_RS13225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH54_RS13230	COG0254	rRNA binding
CH54_RS13235	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH54_RS13240	COG0626	cystathionine gamma-synthase activity
CH54_RS13245	COG0527	aspartate kinase activity
CH54_RS13245	COG0460	homoserine dehydrogenase
CH54_RS13255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH54_RS13270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH54_RS13275	COG0165	Argininosuccinate lyase
CH54_RS13320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_RS13325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH54_RS13325	COG0678	peroxiredoxin activity
CH54_RS13335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH54_RS13350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH54_RS13360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH54_RS13400	COG0583	DNA-binding transcription factor activity
CH54_RS13405	COG3085	chromosome segregation
CH54_RS13420	COG3978	acetolactate synthase activity
CH54_RS13425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH54_RS13430	COG0129	dihydroxy-acid dehydratase activity
CH54_RS13435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH54_RS13440	COG0583	DNA-binding transcription factor activity
CH54_RS13445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH54_RS13475	COG3121	Chaperone
CH54_RS13490	COG3121	Chaperone
CH54_RS13500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH54_RS13510	COG0248	Ppx GppA phosphatase
CH54_RS13520	COG3118	belongs to the thioredoxin family
CH54_RS13525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH54_RS13535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH54_RS13540	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH54_RS13545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH54_RS13550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH54_RS13555	COG1088	dTDP-glucose 4,6-dehydratase activity
CH54_RS13560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH54_RS13565	COG0456	acetyltransferase
CH54_RS13570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH54_RS13575	COG2244	polysaccharide biosynthetic process
CH54_RS13580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH54_RS13620	COG3071	HemY protein
CH54_RS13625	COG2959	enzyme of heme biosynthesis
CH54_RS13630	COG1587	Uroporphyrinogen-III synthase
CH54_RS13635	COG0181	hydroxymethylbilane synthase activity
CH54_RS13640	COG3072	Adenylate cyclase
CH54_RS13645	COG1965	Belongs to the frataxin family
CH54_RS13650	COG5567	small periplasmic lipoprotein
CH54_RS13655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH54_RS13660	COG3159	Protein conserved in bacteria
CH54_RS13665	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH54_RS13670	COG1011	Hydrolase
CH54_RS13675	COG0210	DNA helicase
CH54_RS13685	COG5441	Belongs to the UPF0261 family
CH54_RS13690	COG5564	TIM-barrel signal transduction protein
CH54_RS13710	COG2050	protein possibly involved in aromatic compounds catabolism
CH54_RS13715	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CH54_RS13720	COG0514	ATP-dependent DNA helicase (RecQ)
CH54_RS13725	COG1280	lysine exporter protein (LysE YggA)
CH54_RS13730	COG1280	lysine exporter protein (LysE YggA)
CH54_RS13735	COG2267	carboxylic ester hydrolase activity
CH54_RS13740	COG0561	phosphatase activity
CH54_RS13745	COG0584	glycerophosphoryl diester phosphodiesterase
CH54_RS13750	COG2271	Major facilitator Superfamily
CH54_RS13755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH54_RS13765	COG0247	lactate metabolic process
CH54_RS13775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH54_RS13780	COG0425	Belongs to the sulfur carrier protein TusA family
CH54_RS13790	COG3714	YhhN family
CH54_RS13805	COG3776	membrane
CH54_RS13810	COG0742	ribosomal rna small subunit methyltransferase
CH54_RS13815	COG0552	protein localization to endoplasmic reticulum
CH54_RS13820	COG2884	Cell division ATP-binding protein ftsE
CH54_RS13825	COG2177	Part of the ABC transporter FtsEX involved in
CH54_RS13850	COG0683	leucine binding
CH54_RS13860	COG4177	L-phenylalanine transmembrane transporter activity
CH54_RS13870	COG0410	ABC transporter
CH54_RS13905	COG1653	transport
CH54_RS13910	COG1175	transmembrane transport
CH54_RS13915	COG0395	ABC-type sugar transport system, permease component
CH54_RS13920	COG3842	ATPase activity
CH54_RS13925	COG0584	glycerophosphoryl diester phosphodiesterase
CH54_RS13930	COG0679	Auxin Efflux Carrier
CH54_RS13935	COG0697	spore germination
CH54_RS13940	COG0583	DNA-binding transcription factor activity
CH54_RS13945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH54_RS13950	COG0412	Dienelactone hydrolase
CH54_RS13965	COG1966	Carbon starvation protein
CH54_RS13970	COG0586	Pfam SNARE associated Golgi protein
CH54_RS13975	COG1322	Protein conserved in bacteria
CH54_RS13980	COG2226	methyltransferase
CH54_RS13990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH54_RS13995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH54_RS14000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH54_RS14005	COG0805	protein transport
CH54_RS14025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH54_RS14035	COG0183	Belongs to the thiolase family
CH54_RS14040	COG1024	Enoyl-CoA hydratase
CH54_RS14040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH54_RS14045	COG0006	proline dipeptidase activity
CH54_RS14050	COG1739	Uncharacterized protein family UPF0029
CH54_RS14055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH54_RS14095	COG1072	(Pantothenic acid kinase))
CH54_RS14130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CH54_RS14140	COG0250	Participates in transcription elongation, termination and antitermination
CH54_RS14145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH54_RS14150	COG0081	regulation of translation
CH54_RS14155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH54_RS14165	COG0085	RNA polymerase activity
CH54_RS14175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH54_RS14180	COG2022	thiamine diphosphate biosynthetic process
CH54_RS14185	COG2104	thiamine diphosphate biosynthetic process
CH54_RS14190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH54_RS14205	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CH54_RS14210	COG2816	NAD+ diphosphatase activity
CH54_RS14215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH54_RS14220	COG1515	deoxyribonuclease V activity
CH54_RS14240	COG0151	Belongs to the GarS family
CH54_RS14245	COG0138	bifunctional purine biosynthesis protein purh
CH54_RS14280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH54_RS14285	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH54_RS14290	COG2224	Isocitrate lyase
CH54_RS14295	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH54_RS14300	COG1414	Transcriptional regulator
CH54_RS14325	COG0527	aspartate kinase activity
CH54_RS14335	COG3223	Belongs to the PsiE family
CH54_RS14340	COG3833	ABC-type maltose transport systems, permease component
CH54_RS14345	COG1175	transmembrane transport
CH54_RS14350	COG2182	Extracellular solute-binding protein
CH54_RS14375	COG3161	chorismate lyase activity
CH54_RS14380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CH54_RS14385	COG2937	Belongs to the GPAT DAPAT family
CH54_RS14390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH54_RS14395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH54_RS14400	COG3237	CsbD-like
CH54_RS14405	COG0735	belongs to the Fur family
CH54_RS14410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH54_RS14440	COG1448	Aminotransferase
CH54_RS14445	COG2315	Protein conserved in bacteria
CH54_RS14450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH54_RS14475	COG2252	PERMEase
CH54_RS14480	COG0025	NhaP-type Na H and K H
CH54_RS14485	COG0583	DNA-binding transcription factor activity
CH54_RS14490	COG1380	Effector of murein hydrolase LrgA
CH54_RS14505	COG1560	Kdo2-lipid A biosynthetic process
CH54_RS14510	COG0471	metal ion transport
CH54_RS14520	COG1278	Cold shock
CH54_RS14525	COG1278	Cold shock
CH54_RS14530	COG3133	Outer membrane lipoprotein
CH54_RS14535	COG3706	GGDEF domain
CH54_RS14540	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH54_RS14545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH54_RS14550	COG2264	protein methyltransferase activity
CH54_RS14555	COG4145	pantothenate transmembrane transporter activity
CH54_RS14560	COG3924	membrane
CH54_RS14565	COG0439	Biotin carboxylase
CH54_RS14570	COG0511	ligase activity, forming carbon-carbon bonds
CH54_RS14575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH54_RS14580	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH54_RS14590	COG0604	alcohol dehydrogenase
CH54_RS14595	COG2200	EAL domain
CH54_RS14595	COG2199	diguanylate cyclase activity
CH54_RS14600	COG1077	Cell shape determining protein MreB Mrl
CH54_RS14605	COG1792	Involved in formation and maintenance of cell shape
CH54_RS14610	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH54_RS14615	COG0424	maF-like protein
CH54_RS14620	COG1530	ribonuclease E activity
CH54_RS14625	COG3164	Protein of unknown function
CH54_RS14630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH54_RS14635	COG0312	modulator of DNA gyrase
CH54_RS14640	COG0583	DNA-binding transcription factor activity
CH54_RS14650	COG1566	PFAM secretion protein HlyD family protein
CH54_RS14655	COG1289	transmembrane transporter activity
CH54_RS14670	COG2732	(Barnase) inhibitor
CH54_RS14675	COG3028	Belongs to the UPF0307 family
CH54_RS14680	COG0312	modulator of DNA gyrase
CH54_RS14685	COG3783	Cytochrome b(562)
CH54_RS14690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH54_RS14720	COG3964	amidohydrolase
CH54_RS14735	COG2706	6-phosphogluconolactonase activity
CH54_RS14740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS14740	COG3711	transcriptional antiterminator
CH54_RS14745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH54_RS14755	COG1263	PTS System
CH54_RS14755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS14760	COG0366	Alpha amylase catalytic
CH54_RS14770	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH54_RS14775	COG0540	Belongs to the ATCase OTCase family
CH54_RS14780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH54_RS14785	COG1660	Displays ATPase and GTPase activities
CH54_RS14800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH54_RS14805	COG1137	ATPase activity
CH54_RS14810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH54_RS14815	COG3117	lipopolysaccharide transmembrane transporter activity
CH54_RS14820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH54_RS14825	COG0517	IMP dehydrogenase activity
CH54_RS14825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH54_RS14830	COG0530	calcium, potassium:sodium antiporter activity
CH54_RS14835	COG1127	ABC transporter
CH54_RS14840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH54_RS14845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH54_RS14850	COG2854	intermembrane phospholipid transfer
CH54_RS14855	COG3113	response to antibiotic
CH54_RS14860	COG5007	Belongs to the BolA IbaG family
CH54_RS14865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH54_RS14870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH54_RS14875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH54_RS14880	COG3105	Protein conserved in bacteria
CH54_RS14885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH54_RS14890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH54_RS14895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH54_RS14900	COG0625	glutathione transferase activity
CH54_RS14905	COG2969	positive regulation of protein catabolic process
CH54_RS14915	COG0493	'glutamate synthase
CH54_RS14920	COG0069	glutamate synthase activity
CH54_RS14920	COG0067	glutamate synthase
CH54_RS14920	COG0070	glutamate synthase
CH54_RS14925	COG1242	4 iron, 4 sulfur cluster binding
CH54_RS14930	COG5002	protein histidine kinase activity
CH54_RS14930	COG0784	Response regulator, receiver
CH54_RS14930	COG2198	Histidine kinase
CH54_RS14935	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH54_RS14940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH54_RS14945	COG2823	Periplasmic or secreted lipoprotein
CH54_RS14950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH54_RS14955	COG0792	nuclease activity
CH54_RS14965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH54_RS15045	COG0667	Aldo Keto reductase
CH54_RS15055	COG4221	oxidoreductase activity
CH54_RS15060	COG1064	alcohol dehydrogenase
CH54_RS15065	COG1741	Belongs to the pirin family
CH54_RS15070	COG0583	DNA-binding transcription factor activity
CH54_RS15075	COG0435	Glutathione S-transferase
CH54_RS15080	COG2259	Doxx family
CH54_RS15090	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH54_RS15095	COG4575	ribosome binding
CH54_RS15110	COG0586	Pfam SNARE associated Golgi protein
CH54_RS15125	COG2271	Major facilitator Superfamily
CH54_RS15130	COG1904	glucuronate isomerase
CH54_RS15135	COG0246	Mannitol dehydrogenase
CH54_RS15140	COG2721	sulfolactate sulfo-lyase activity
CH54_RS15150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH54_RS15155	COG0861	Integral membrane protein TerC family
CH54_RS15160	COG0673	inositol 2-dehydrogenase activity
CH54_RS15165	COG1451	nucleotide metabolic process
CH54_RS15175	COG2813	Specifically methylates the guanine in position
CH54_RS15180	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH54_RS15180	COG1902	pentaerythritol trinitrate reductase activity
CH54_RS15190	COG3247	response to pH
CH54_RS15195	COG0076	glutamate decarboxylase activity
CH54_RS15200	COG0531	amino acid
CH54_RS15210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS15210	COG1263	PTS System
CH54_RS15215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH54_RS15225	COG1472	Belongs to the glycosyl hydrolase 3 family
CH54_RS15235	COG3876	Protein conserved in bacteria
CH54_RS15250	COG0358	DNA primase activity
CH54_RS15255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CH54_RS15260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH54_RS15265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH54_RS15270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH54_RS15275	COG1968	undecaprenyl-diphosphatase activity
CH54_RS15280	COG0617	tRNA 3'-terminal CCA addition
CH54_RS15285	COG4991	sh3 domain protein
CH54_RS15290	COG3025	triphosphatase activity
CH54_RS15295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH54_RS15300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH54_RS15300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH54_RS15305	COG0531	amino acid
CH54_RS15315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CH54_RS15320	COG3384	dioxygenase
CH54_RS15325	COG0754	glutathionylspermidine amidase activity
CH54_RS15330	COG5463	Belongs to the UPF0441 family
CH54_RS15335	COG1538	Outer membrane efflux protein
CH54_RS15340	COG0494	nUDIX hydrolase
CH54_RS15345	COG3151	Protein conserved in bacteria
CH54_RS15350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH54_RS15355	COG3150	esterase
CH54_RS15365	COG0583	DNA-binding transcription factor activity
CH54_RS15370	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH54_RS15375	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH54_RS15390	COG2132	Multicopper oxidase
CH54_RS15400	COG0656	L-ascorbic acid biosynthetic process
CH54_RS15405	COG1979	alcohol dehydrogenase
CH54_RS15410	COG2207	Transcriptional regulator
CH54_RS15415	COG0586	Pfam SNARE associated Golgi protein
CH54_RS15430	COG0848	biopolymer transport protein
CH54_RS15480	COG4964	Belongs to the GSP D family
CH54_RS15510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS15535	COG4774	siderophore transport
CH54_RS15550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CH54_RS15560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_RS15565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH54_RS15570	COG1120	ATPase activity
CH54_RS15575	COG4592	Periplasmic binding protein
CH54_RS15580	COG1169	isochorismate synthase
CH54_RS15585	COG1021	2,3-dihydroxybenzoate-AMP ligase
CH54_RS15590	COG3433	isochorismatase activity
CH54_RS15590	COG1535	isochorismatase
CH54_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS15600	COG2271	Major facilitator Superfamily
CH54_RS15605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_RS15620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH54_RS15630	COG1987	bacterial-type flagellum assembly
CH54_RS15655	COG1677	Flagellar hook-basal body complex protein FliE
CH54_RS15700	COG1815	bacterial-type flagellum-dependent cell motility
CH54_RS15705	COG1558	bacterial-type flagellum-dependent cell motility
CH54_RS15710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH54_RS15725	COG4786	Flagellar basal body rod
CH54_RS15735	COG1706	bacterial-type flagellum-dependent cell motility
CH54_RS15750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH54_RS15765	COG3710	Transcriptional regulator
CH54_RS15770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH54_RS15775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH54_RS15780	COG1516	flagellar protein fliS
CH54_RS15800	COG1191	sigma factor activity
CH54_RS15805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH54_RS15815	COG3133	Outer membrane lipoprotein
CH54_RS15820	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH54_RS15825	COG0437	4 iron, 4 sulfur cluster binding
CH54_RS15830	COG5557	Pfam Polysulphide reductase, NrfD
CH54_RS15835	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH54_RS15840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH54_RS15845	COG1773	rubredoxin
CH54_RS15855	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH54_RS15860	COG0298	carbon dioxide binding
CH54_RS15865	COG0409	Hydrogenase expression formation protein
CH54_RS15870	COG0309	Hydrogenase expression formation protein (HypE)
CH54_RS15875	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH54_RS15885	COG5001	Diguanylate cyclase
CH54_RS15890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS15910	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CH54_RS15915	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH54_RS15920	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH54_RS15935	COG0477	Major facilitator Superfamily
CH54_RS15950	COG4607	ABC-type enterochelin transport system periplasmic component
CH54_RS15960	COG4605	iron ion homeostasis
CH54_RS15965	COG4604	ABC transporter, ATP-binding protein
CH54_RS15995	COG1289	transmembrane transporter activity
CH54_RS16030	COG2885	chlorophyll binding
CH54_RS16050	COG3179	chitinase
CH54_RS16195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH54_RS16200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH54_RS16210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH54_RS16215	COG0656	L-ascorbic acid biosynthetic process
CH54_RS16245	COG2211	Major facilitator Superfamily
CH54_RS16325	COG2885	chlorophyll binding
CH54_RS16325	COG3047	cAMP biosynthetic process
CH54_RS16350	COG3501	Rhs element vgr protein
CH54_RS16365	COG3675	Pfam Lipase (class 3)
CH54_RS16445	COG0210	DNA helicase
CH54_RS16495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH54_RS16505	COG1982	Orn Lys Arg decarboxylase major
CH54_RS16515	COG0741	lytic transglycosylase activity
CH54_RS16520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CH54_RS16525	COG1194	a g-specific adenine glycosylase
CH54_RS16530	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH54_RS16535	COG3171	Protein conserved in bacteria
CH54_RS16550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH54_RS16555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH54_RS16560	COG1872	DUF167
CH54_RS16565	COG0762	integral membrane protein
CH54_RS16570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH54_RS16575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH54_RS16580	COG2805	Type II/IV secretion system protein
CH54_RS16590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH54_RS16595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH54_RS16600	COG1678	Uncharacterized ACR, COG1678
CH54_RS16605	COG0189	ligase activity
CH54_RS16610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH54_RS16615	COG2356	endonuclease I
CH54_RS16620	COG3091	SprT-like family
CH54_RS16625	COG0640	Transcriptional regulator
CH54_RS16645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CH54_RS16655	COG1166	arginine decarboxylase activity
CH54_RS16665	COG0501	Belongs to the peptidase M48B family
CH54_RS16670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH54_RS16675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH54_RS16680	COG0126	phosphoglycerate kinase activity
CH54_RS16685	COG0191	fructose-bisphosphate aldolase activity
CH54_RS16700	COG1279	arginine transmembrane transporter activity
CH54_RS16710	COG0583	DNA-binding transcription factor activity
CH54_RS16715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH54_RS16720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH54_RS16725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH54_RS16730	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH54_RS16735	COG3079	Belongs to the UPF0149 family
CH54_RS16740	COG0006	proline dipeptidase activity
CH54_RS16745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH54_RS16750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH54_RS16755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH54_RS16760	COG0509	glycine decarboxylation via glycine cleavage system
CH54_RS16765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH54_RS16765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH54_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS16780	COG1272	protein, Hemolysin III
CH54_RS16785	COG0354	folic acid binding
CH54_RS16800	COG0745	RESPONSE REGULATOR receiver
CH54_RS16805	COG2205	protein histidine kinase activity
CH54_RS16810	COG4452	Inner membrane protein CreD
CH54_RS16815	COG0716	FMN binding
CH54_RS16820	COG4974	Belongs to the 'phage' integrase family
CH54_RS16825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH54_RS16830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH54_RS16840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CH54_RS16850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CH54_RS16945	COG1522	sequence-specific DNA binding
CH54_RS16960	COG2271	Major facilitator Superfamily
CH54_RS16965	COG1609	Transcriptional regulator
CH54_RS16970	COG0484	heat shock protein binding
CH54_RS16980	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS16985	COG1733	regulation of RNA biosynthetic process
CH54_RS16990	COG0288	reversible hydration of carbon dioxide
CH54_RS17010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH54_RS17020	COG2165	general secretion pathway protein
CH54_RS17050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH54_RS17085	COG0583	DNA-binding transcription factor activity
CH54_RS17090	COG2814	Major facilitator Superfamily
CH54_RS17095	COG0583	DNA-binding transcription factor activity
CH54_RS17105	COG1609	Transcriptional regulator
CH54_RS17115	COG0318	PFAM AMP-dependent synthetase and ligase
CH54_RS17115	COG0204	Acyl-transferase
CH54_RS17120	COG0477	Major facilitator Superfamily
CH54_RS17125	COG0667	Aldo Keto reductase
CH54_RS17130	COG0861	Integral membrane protein TerC family
CH54_RS17135	COG3066	DNA modification
CH54_RS17145	COG1051	belongs to the nudix hydrolase family
CH54_RS17155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH54_RS17160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CH54_RS17185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH54_RS17190	COG1025	Belongs to the peptidase M16 family
CH54_RS17195	COG1074	ATP-dependent DNA helicase activity
CH54_RS17200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH54_RS17205	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH54_RS17205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH54_RS17210	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH54_RS17230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH54_RS17235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH54_RS17240	COG2166	iron-sulfur cluster assembly
CH54_RS17245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH54_RS17255	COG0583	DNA-binding transcription factor activity
CH54_RS17260	COG2363	Small membrane protein
CH54_RS17265	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH54_RS17270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH54_RS17275	COG1611	Belongs to the LOG family
CH54_RS17280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH54_RS17280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH54_RS17290	COG3098	single-species biofilm formation
CH54_RS17295	COG0564	pseudouridine synthase activity
CH54_RS17310	COG2171	N-acyltransferase activity
CH54_RS17315	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH54_RS17325	COG0052	Belongs to the universal ribosomal protein uS2 family
CH54_RS17330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CH54_RS17335	COG0528	UMP kinase activity
CH54_RS17340	COG0233	cytoplasmic translational termination
CH54_RS17345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH54_RS17355	COG0575	Belongs to the CDS family
CH54_RS17360	COG0750	zinc metalloprotease
CH54_RS17370	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH54_RS17375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_RS17380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH54_RS17385	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_RS17395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH54_RS17400	COG0587	DNA-directed DNA polymerase activity
CH54_RS17405	COG0825	malonyl-CoA metabolic process
CH54_RS17420	COG0346	lactoylglutathione lyase activity
CH54_RS17435	COG4568	rho-dependent transcription termination
CH54_RS17445	COG4681	YaeQ
CH54_RS17455	COG3015	lipoprotein NlpE involved in copper resistance
CH54_RS17460	COG0442	prolyl-tRNA aminoacylation
CH54_RS17465	COG1720	tRNA m6t6A37 methyltransferase activity
CH54_RS17475	COG1464	Belongs to the NlpA lipoprotein family
CH54_RS17480	COG2011	ABC-type metal ion transport system permease component
CH54_RS17490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH54_RS17520	COG5544	Lipoprotein
CH54_RS17525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH54_RS17530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH54_RS17530	COG1042	CoA-binding domain protein
CH54_RS17530	COG0045	succinate-CoA ligase (ADP-forming) activity
CH54_RS17535	COG3148	PFAM DTW domain containing protein
CH54_RS17540	COG3118	belongs to the thioredoxin family
CH54_RS17545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH54_RS17550	COG2814	Major facilitator Superfamily
CH54_RS17555	COG1566	PFAM secretion protein HlyD family protein
CH54_RS17560	COG1846	Transcriptional regulator
CH54_RS17570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH54_RS17575	COG2814	Major facilitator Superfamily
CH54_RS17585	COG0436	Aminotransferase
CH54_RS17590	COG0235	Class ii aldolase
CH54_RS17595	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH54_RS17600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH54_RS17605	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CH54_RS17610	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH54_RS17615	COG1960	acyl-CoA dehydrogenase activity
CH54_RS17620	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH54_RS17625	COG0121	glutamine amidotransferase
CH54_RS17630	COG3034	peptidoglycan biosynthetic process
CH54_RS17635	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_RS17640	COG1805	sodium ion transport
CH54_RS17645	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_RS17650	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_RS17655	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH54_RS17660	COG2871	sodium ion transport
CH54_RS17665	COG1477	protein flavinylation
CH54_RS17670	COG2991	Protein conserved in bacteria
CH54_RS17685	COG2964	Protein conserved in bacteria
CH54_RS17700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH54_RS17705	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH54_RS17710	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH54_RS17730	COG1086	Polysaccharide biosynthesis protein
CH54_RS17755	COG0438	transferase activity, transferring glycosyl groups
CH54_RS17770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH54_RS17780	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CH54_RS17785	COG1073	alpha beta
CH54_RS17795	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH54_RS17800	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH54_RS17805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_RS17810	COG2313	pseudouridylate synthase activity
CH54_RS17815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH54_RS17820	COG2188	Transcriptional regulator
CH54_RS17840	COG3459	Glycosyltransferase 36 associated
CH54_RS17855	COG2226	methyltransferase
CH54_RS17875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH54_RS17880	COG3123	guanosine phosphorylase activity
CH54_RS17885	COG2974	May be involved in recombination
CH54_RS17890	COG1940	carbohydrate kinase activity
CH54_RS17895	COG0419	ATPase involved in DNA repair
CH54_RS17900	COG0420	3'-5' exonuclease activity
CH54_RS17905	COG0745	RESPONSE REGULATOR receiver
CH54_RS17910	COG5002	protein histidine kinase activity
CH54_RS17930	COG0366	Alpha amylase catalytic
CH54_RS17945	COG0450	alkyl hydroperoxide reductase
CH54_RS17950	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH54_RS17980	COG0343	queuine tRNA-ribosyltransferase activity
CH54_RS17985	COG1862	Preprotein translocase
CH54_RS17990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH54_RS17995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH54_RS18010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH54_RS18010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH54_RS18015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CH54_RS18020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH54_RS18025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH54_RS18030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH54_RS18035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH54_RS18040	COG0142	geranyltranstransferase activity
CH54_RS18045	COG1722	exodeoxyribonuclease VII activity
CH54_RS18050	COG0301	tRNA thio-modification
CH54_RS18050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH54_RS18060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH54_RS18065	COG1666	GTP binding
CH54_RS18070	COG2814	Major facilitator Superfamily
CH54_RS18075	COG0109	protoheme IX farnesyltransferase activity
CH54_RS18080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH54_RS18085	COG1845	cytochrome c oxidase, subunit III
CH54_RS18090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH54_RS18095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH54_RS18105	COG2223	nitrite transmembrane transporter activity
CH54_RS18110	COG3056	Lipoprotein
CH54_RS18115	COG0271	Belongs to the BolA IbaG family
CH54_RS18120	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH54_RS18130	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH54_RS18135	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH54_RS18140	COG0776	regulation of translation
CH54_RS18145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH54_RS18150	COG1555	photosystem II stabilization
CH54_RS18155	COG0824	Thioesterase
CH54_RS18160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH54_RS18165	COG4533	DNA binding
CH54_RS18170	COG0561	phosphatase activity
CH54_RS18180	COG1522	sequence-specific DNA binding
CH54_RS18185	COG1132	(ABC) transporter
CH54_RS18190	COG1132	(ABC) transporter
CH54_RS18195	COG0347	Belongs to the P(II) protein family
CH54_RS18200	COG0004	ammonium transporteR
CH54_RS18205	COG1946	Acyl-CoA thioesterase
CH54_RS18210	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH54_RS18215	COG3695	enzyme binding
CH54_RS18235	COG1121	(ABC) transporter
CH54_RS18240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH54_RS18245	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH54_RS18250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH54_RS18255	COG0254	rRNA binding
CH54_RS18270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH54_RS18275	COG3457	Alanine racemase
CH54_RS18285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH54_RS18290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS18295	COG1309	transcriptional regulator
CH54_RS18300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH54_RS18305	COG1196	nuclear chromosome segregation
CH54_RS18305	COG3264	Mechanosensitive ion channel
CH54_RS18320	COG2832	Protein of unknown function (DUF454)
CH54_RS18325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH54_RS18330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CH54_RS18335	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CH54_RS18340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH54_RS18345	COG0326	Molecular chaperone. Has ATPase activity
CH54_RS18350	COG0563	adenylate kinase activity
CH54_RS18355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH54_RS18360	COG2244	polysaccharide biosynthetic process
CH54_RS18365	COG1216	Glycosyl transferase, family 2
CH54_RS18365	COG1442	glycosyl transferase family 8
CH54_RS18370	COG1215	transferase activity, transferring glycosyl groups
CH54_RS18375	COG0438	transferase activity, transferring glycosyl groups
CH54_RS18380	COG0438	transferase activity, transferring glycosyl groups
CH54_RS18385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH54_RS18405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH54_RS18410	COG4651	solute:proton antiporter activity
CH54_RS18410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH54_RS18415	COG2223	nitrite transmembrane transporter activity
CH54_RS18420	COG0737	Belongs to the 5'-nucleotidase family
CH54_RS18425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH54_RS18430	COG3735	TraB family
CH54_RS18435	COG2217	Heavy metal translocating P-type atpase
CH54_RS18440	COG0789	Transcriptional regulator
CH54_RS18445	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH54_RS18450	COG0330	HflC and HflK could
CH54_RS18455	COG3118	belongs to the thioredoxin family
CH54_RS18460	COG0300	oxidoreductase activity
CH54_RS18465	COG2755	lipolytic protein G-D-S-L family
CH54_RS18470	COG4181	ATPase activity
CH54_RS18475	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH54_RS18480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH54_RS18485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH54_RS18490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH54_RS18495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH54_RS18500	COG0215	cysteine-tRNA ligase activity
CH54_RS18505	COG2501	S4 domain
CH54_RS18510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH54_RS18520	COG0582	viral genome integration into host DNA
CH54_RS18575	COG3723	Recombinational DNA repair protein, rece pathway
CH54_RS18715	COG3772	lysozyme
CH54_RS18735	COG3728	DNA packaging
CH54_RS18895	COG2116	formate transmembrane transporter activity
CH54_RS18905	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH54_RS18910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH54_RS18915	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH54_RS18920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH54_RS18925	COG1138	Cytochrome C-type biogenesis protein
CH54_RS18930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH54_RS18935	COG3088	subunit of a heme lyase
CH54_RS18935	COG4235	cytochrome complex assembly
CH54_RS18940	COG4235	cytochrome complex assembly
CH54_RS18940	COG3088	subunit of a heme lyase
CH54_RS18955	COG3691	Protein conserved in bacteria
CH54_RS18960	COG0183	Belongs to the thiolase family
CH54_RS18965	COG1024	Enoyl-CoA hydratase
CH54_RS18965	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH54_RS18970	COG2062	phosphohistidine phosphatase, SixA
CH54_RS18975	COG2840	Smr protein MutS2
CH54_RS18980	COG2890	protein-(glutamine-N5) methyltransferase activity
CH54_RS18985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH54_RS18990	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH54_RS18995	COG0730	response to heat
CH54_RS19000	COG3101	peptidyl-lysine hydroxylation
CH54_RS19010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH54_RS19010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH54_RS19015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH54_RS19025	COG1794	racemase activity, acting on amino acids and derivatives
CH54_RS19035	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH54_RS19040	COG2723	6-phospho-beta-galactosidase activity
CH54_RS19045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH54_RS19055	COG1609	Transcriptional regulator
CH54_RS19065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH54_RS19080	COG4232	protein-disulfide reductase activity
CH54_RS19090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH54_RS19095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH54_RS19105	COG0697	spore germination
CH54_RS19110	COG2207	Transcriptional regulator
CH54_RS19115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH54_RS19120	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH54_RS19130	COG0586	Pfam SNARE associated Golgi protein
CH54_RS19140	COG0285	dihydrofolate synthase activity
CH54_RS19145	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH54_RS19150	COG1286	toxin biosynthetic process
CH54_RS19155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH54_RS19165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS19170	COG4215	(ABC) transporter
CH54_RS19175	COG4160	amino acid transport
CH54_RS19180	COG4598	ABC transporter
CH54_RS19185	COG1090	epimerase
CH54_RS19195	COG0622	Phosphoesterase
CH54_RS19200	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH54_RS19205	COG3037	sugar-specific permease SgaT UlaA
CH54_RS19220	COG1609	Transcriptional regulator
CH54_RS19225	COG0857	belongs to the CobB CobQ family
CH54_RS19225	COG0280	phosphate acetyltransferase
CH54_RS19235	COG3092	negative regulation of chromosome organization
CH54_RS19240	COG3013	Belongs to the UPF0304 family
CH54_RS19245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH54_RS19255	COG0471	metal ion transport
CH54_RS19255	COG0490	domain, Protein
CH54_RS19260	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH54_RS19265	COG0436	Aminotransferase
CH54_RS19270	COG0583	DNA-binding transcription factor activity
CH54_RS19280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_RS19285	COG0649	NAD binding
CH54_RS19285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_RS19300	COG1034	ATP synthesis coupled electron transport
CH54_RS19305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH54_RS19310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_RS19315	COG0839	Belongs to the complex I subunit 6 family
CH54_RS19320	COG0713	ATP synthesis coupled electron transport
CH54_RS19325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH54_RS19330	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH54_RS19335	COG1007	ATP synthesis coupled electron transport
CH54_RS19350	COG2731	YhcH YjgK YiaL family protein
CH54_RS19355	COG3265	gluconokinase activity
CH54_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
CH54_RS19365	COG1609	Transcriptional regulator
CH54_RS19370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH54_RS19380	COG4702	Belongs to the UPF0303 family
CH54_RS19385	COG0129	dihydroxy-acid dehydratase activity
CH54_RS19390	COG4575	ribosome binding
CH54_RS19400	COG1169	isochorismate synthase
CH54_RS19405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH54_RS19410	COG0596	Alpha beta hydrolase
CH54_RS19415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH54_RS19420	COG1441	menaquinone biosynthetic process
CH54_RS19440	COG0814	amino acid
CH54_RS19450	COG4574	serine-type endopeptidase inhibitor activity
CH54_RS19455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH54_RS19465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH54_RS19470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH54_RS19480	COG0784	Response regulator, receiver
CH54_RS19480	COG2205	protein histidine kinase activity
CH54_RS19490	COG2198	Histidine kinase
CH54_RS19490	COG0642	Histidine kinase
CH54_RS19495	COG2223	nitrite transmembrane transporter activity
CH54_RS19510	COG1132	(ABC) transporter
CH54_RS19520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH54_RS19535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH54_RS19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH54_RS19575	COG1263	PTS System
CH54_RS19575	COG2190	(PTS) system
CH54_RS19580	COG2723	6-phospho-beta-galactosidase activity
CH54_RS19595	COG3082	Protein of unknown function (DUF1414)
CH54_RS19600	COG3081	Nucleoid-associated protein
CH54_RS19610	COG1061	Type III restriction enzyme res subunit
CH54_RS19615	COG1187	pseudouridine synthase activity
CH54_RS19620	COG2814	Major facilitator Superfamily
CH54_RS19635	COG4172	Belongs to the ABC transporter superfamily
CH54_RS19640	COG4239	(ABC) transporter, permease
CH54_RS19645	COG4174	ABC transporter (Permease)
CH54_RS19650	COG4166	transmembrane transport
CH54_RS19655	COG2200	EAL domain
CH54_RS19665	COG0791	NLP P60 protein
CH54_RS19680	COG0523	cobalamin synthesis protein
CH54_RS19690	COG2186	Transcriptional regulator
CH54_RS19695	COG0246	Mannitol dehydrogenase
CH54_RS19705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH54_RS19735	COG1105	Belongs to the carbohydrate kinase PfkB family
CH54_RS19740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH54_RS19740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH54_RS19740	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH54_RS19745	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH54_RS19750	COG2855	membrane
CH54_RS19765	COG0583	DNA-binding transcription factor activity
CH54_RS19770	COG0833	amino acid
CH54_RS19780	COG4771	TonB-dependent receptor
CH54_RS19785	COG0625	glutathione transferase activity
CH54_RS19810	COG2011	ABC-type metal ion transport system permease component
CH54_RS19825	COG0626	cystathionine gamma-synthase activity
CH54_RS19835	COG1686	Belongs to the peptidase S11 family
CH54_RS19840	COG1760	l-serine dehydratase
CH54_RS19845	COG0814	amino acid
CH54_RS19850	COG1349	DNA-binding transcription factor activity
CH54_RS19855	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH54_RS19860	COG0671	phosphoesterase, PA-phosphatase related
CH54_RS19870	COG0569	domain protein
CH54_RS19870	COG2985	domain, Protein
CH54_RS19890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH54_RS19895	COG3842	ATPase activity
CH54_RS19900	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH54_RS19905	COG1177	transmembrane transport
CH54_RS19915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH54_RS19920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS19925	COG4160	amino acid transport
CH54_RS19930	COG4215	(ABC) transporter
CH54_RS19935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH54_RS19940	COG1126	abc transporter atp-binding protein
CH54_RS19950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH54_RS19955	COG0702	epimerase
CH54_RS19960	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH54_RS19970	COG0028	Belongs to the TPP enzyme family
CH54_RS19975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH54_RS19980	COG1151	hydroxylamine reductase activity
CH54_RS19985	COG2431	L-lysine efflux transmembrane transporter activity
CH54_RS19990	COG3593	DNA synthesis involved in DNA repair
CH54_RS19995	COG2990	Protein conserved in bacteria
CH54_RS20000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH54_RS20010	COG1278	Cold shock
CH54_RS20015	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH54_RS20020	COG0542	response to heat
CH54_RS20025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH54_RS20030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CH54_RS20035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH54_RS20045	COG0492	ferredoxin-NADP+ reductase activity
CH54_RS20050	COG1522	sequence-specific DNA binding
CH54_RS20055	COG1674	ftsk spoiiie
CH54_RS20055	COG3107	peptidoglycan biosynthetic process
CH54_RS20060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH54_RS20065	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH54_RS20070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH54_RS20075	COG2814	Major facilitator Superfamily
CH54_RS20080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH54_RS20085	COG1882	Formate acetyltransferase
CH54_RS20090	COG2116	formate transmembrane transporter activity
CH54_RS20095	COG1944	ATP diphosphatase activity
CH54_RS20100	COG0252	asparaginase activity
CH54_RS20105	COG2323	membrane
CH54_RS20115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH54_RS20120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH54_RS20125	COG0539	negative regulation of cytoplasmic translation
CH54_RS20135	COG0658	competence protein
CH54_RS20135	COG2333	competence protein COMEC
CH54_RS20145	COG1663	tetraacyldisaccharide 4'-kinase activity
CH54_RS20150	COG5383	Protein conserved in bacteria
CH54_RS20155	COG1278	Cold shock
CH54_RS20160	COG2835	tetraacyldisaccharide 4'-kinase activity
CH54_RS20165	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CH54_RS20170	COG3173	Aminoglycoside phosphotransferase
CH54_RS20175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH54_RS20180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH54_RS20185	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH54_RS20195	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH54_RS20200	COG2989	Protein conserved in bacteria
CH54_RS20205	COG3108	Peptidase M15
CH54_RS20210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH54_RS20215	COG2200	EAL domain
CH54_RS20220	COG1448	Aminotransferase
CH54_RS20230	COG0017	Asparaginyl-tRNA synthetase
CH54_RS20235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH54_RS20240	COG0308	aminopeptidase N
CH54_RS20245	COG0167	dihydroorotate dehydrogenase activity
CH54_RS20255	COG3217	Mosc domain protein beta barrel domain protein
CH54_RS20255	COG0633	Ferredoxin
CH54_RS20315	COG3179	chitinase
CH54_RS20360	COG3130	regulation of translation
CH54_RS20445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH54_RS20735	COG3210	domain, Protein
CH54_RS21815	COG0673	inositol 2-dehydrogenase activity
CH54_RS22035	COG3468	outer membrane autotransporter barrel domain protein
CH54_RS22050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family