locus-tag	class	description
CH64_RS00025	COG0583	DNA-binding transcription factor activity
CH64_RS00030	COG0477	Major facilitator Superfamily
CH64_RS00035	COG0302	gtp cyclohydrolase
CH64_RS00040	COG2311	Membrane
CH64_RS00065	COG2116	formate transmembrane transporter activity
CH64_RS00075	COG3383	formate dehydrogenase (NAD+) activity
CH64_RS00080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_RS00085	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH64_RS00095	COG3260	NADH ubiquinone oxidoreductase 20
CH64_RS00100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS00105	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CH64_RS00105	COG3261	NADH dehydrogenase
CH64_RS00110	COG0651	ATP synthesis coupled electron transport
CH64_RS00115	COG4237	Hydrogenase 4 membrane
CH64_RS00120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH64_RS00125	COG0650	Formate hydrogenlyase subunit 4
CH64_RS00130	COG0651	ATP synthesis coupled electron transport
CH64_RS00135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_RS00140	COG0375	protein maturation
CH64_RS00145	COG0298	carbon dioxide binding
CH64_RS00150	COG2949	membrane
CH64_RS00155	COG0281	malic enzyme
CH64_RS00165	COG1346	cytolysis
CH64_RS00170	COG1380	Effector of murein hydrolase LrgA
CH64_RS00175	COG2814	Major facilitator Superfamily
CH64_RS00195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH64_RS00195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CH64_RS00200	COG0489	protein tyrosine kinase activity
CH64_RS00205	COG0572	uridine kinase
CH64_RS00210	COG0717	Belongs to the dCTP deaminase family
CH64_RS00215	COG2982	Protein involved in outer membrane biogenesis
CH64_RS00220	COG3069	C4-dicarboxylate transmembrane transporter activity
CH64_RS00260	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CH64_RS00280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH64_RS00285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CH64_RS00290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CH64_RS00295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CH64_RS00295	COG0140	phosphoribosyl-ATP diphosphatase activity
CH64_RS00300	COG0107	imidazoleglycerol-phosphate synthase activity
CH64_RS00305	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CH64_RS00315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH64_RS00315	COG0131	Imidazoleglycerol-phosphate dehydratase
CH64_RS00320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH64_RS00325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CH64_RS00330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CH64_RS00335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH64_RS00340	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS00345	COG1129	ABC transporter
CH64_RS00350	COG0371	Dehydrogenase
CH64_RS00360	COG0531	amino acid
CH64_RS00365	COG2925	Exonuclease
CH64_RS00375	COG1289	transmembrane transporter activity
CH64_RS00380	COG2926	Belongs to the UPF0265 family
CH64_RS00390	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS00395	COG1129	ABC transporter
CH64_RS00405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CH64_RS00420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CH64_RS00430	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CH64_RS00495	COG1492	cobalamin metabolic process
CH64_RS00515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CH64_RS00525	COG0534	Mate efflux family protein
CH64_RS00530	COG0784	Response regulator, receiver
CH64_RS00530	COG0835	chemotaxis
CH64_RS00540	COG3311	Transcriptional regulator
CH64_RS00615	COG1204	response to ionizing radiation
CH64_RS00690	COG0582	viral genome integration into host DNA
CH64_RS00715	COG3121	Chaperone
CH64_RS00730	COG3121	Chaperone
CH64_RS00740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS00740	COG2205	protein histidine kinase activity
CH64_RS00755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH64_RS00775	COG3842	ATPase activity
CH64_RS00785	COG1840	ABC-type Fe3 transport system, periplasmic component
CH64_RS00790	COG2271	Major facilitator Superfamily
CH64_RS00805	COG4565	transcriptional regulatory protein
CH64_RS00810	COG3290	protein histidine kinase activity
CH64_RS00815	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CH64_RS00820	COG3052	prosthetic group binding
CH64_RS00825	COG2301	Belongs to the HpcH HpaI aldolase family
CH64_RS00830	COG3051	citrate lyase alpha subunit
CH64_RS00845	COG0471	metal ion transport
CH64_RS00860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CH64_RS00890	COG3228	Belongs to the MtfA family
CH64_RS00895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH64_RS00925	COG3321	synthase
CH64_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS00925	COG0604	alcohol dehydrogenase
CH64_RS00930	COG3250	beta-galactosidase activity
CH64_RS00935	COG1609	Transcriptional regulator
CH64_RS00950	COG0840	transmembrane signaling receptor activity
CH64_RS00955	COG1285	pathogenesis
CH64_RS00965	COG2130	NADP-dependent
CH64_RS00970	COG0589	response to stress
CH64_RS00990	COG1360	Flagellar Motor Protein
CH64_RS00995	COG2198	Histidine kinase
CH64_RS00995	COG0643	Histidine kinase
CH64_RS01000	COG0835	chemotaxis
CH64_RS01005	COG0840	transmembrane signaling receptor activity
CH64_RS01010	COG0840	transmembrane signaling receptor activity
CH64_RS01015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CH64_RS01025	COG0745	RESPONSE REGULATOR receiver
CH64_RS01030	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CH64_RS01035	COG4935	Belongs to the peptidase S8 family
CH64_RS01035	COG1404	Belongs to the peptidase S8 family
CH64_RS01040	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH64_RS01045	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH64_RS01055	COG3418	PFAM FlgN family protein
CH64_RS01060	COG2747	anti-sigma28 factor FlgM
CH64_RS01070	COG1815	bacterial-type flagellum-dependent cell motility
CH64_RS01075	COG1558	bacterial-type flagellum-dependent cell motility
CH64_RS01080	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH64_RS01115	COG1256	bacterial-type flagellum assembly
CH64_RS01120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_RS01165	COG2882	bacterial-type flagellum organization
CH64_RS01175	COG1317	bacterial-type flagellum organization
CH64_RS01180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CH64_RS01190	COG1677	Flagellar hook-basal body complex protein FliE
CH64_RS01210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CH64_RS01255	COG1191	sigma factor activity
CH64_RS01265	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CH64_RS01270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS01275	COG0765	amino acid transport
CH64_RS01280	COG1126	abc transporter atp-binding protein
CH64_RS01295	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH64_RS01295	COG0506	proline dehydrogenase activity
CH64_RS01295	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CH64_RS01300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH64_RS01305	COG0672	)-iron permease
CH64_RS01310	COG2822	iron ion transport
CH64_RS01325	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
CH64_RS01330	COG1113	amino acid transport
CH64_RS01340	COG1187	pseudouridine synthase activity
CH64_RS01355	COG0366	Alpha amylase catalytic
CH64_RS01360	COG0840	transmembrane signaling receptor activity
CH64_RS01370	COG3136	membrane protein required for alginate biosynthesis
CH64_RS01380	COG2197	response regulator
CH64_RS01385	COG0322	excinuclease ABC activity
CH64_RS01390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CH64_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS01455	COG0604	alcohol dehydrogenase
CH64_RS01455	COG3321	synthase
CH64_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS01460	COG0561	phosphatase activity
CH64_RS01465	COG2197	response regulator
CH64_RS01470	COG2223	nitrite transmembrane transporter activity
CH64_RS01475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CH64_RS01480	COG1140	nitrate reductase beta subunit
CH64_RS01485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CH64_RS01490	COG2181	nitrate reductase activity
CH64_RS01500	COG3493	citrate carrier protein
CH64_RS01505	COG4565	transcriptional regulatory protein
CH64_RS01510	COG3290	protein histidine kinase activity
CH64_RS01515	COG2066	Belongs to the glutaminase family
CH64_RS01530	COG0672	)-iron permease
CH64_RS01545	COG1136	(ABC) transporter
CH64_RS01545	COG0577	efflux transmembrane transporter activity
CH64_RS01555	COG0577	efflux transmembrane transporter activity
CH64_RS01555	COG1136	(ABC) transporter
CH64_RS01575	COG4114	ferric iron reductase
CH64_RS01580	COG0006	proline dipeptidase activity
CH64_RS01585	COG0457	Tetratricopeptide repeat
CH64_RS01590	COG0726	polysaccharide deacetylase
CH64_RS01590	COG1649	PFAM Uncharacterised BCR, COG1649
CH64_RS01595	COG1215	transferase activity, transferring glycosyl groups
CH64_RS01610	COG1702	phosphate starvation-inducible protein PhoH
CH64_RS01615	COG0387	Pfam Sodium calcium exchanger
CH64_RS01625	COG0583	DNA-binding transcription factor activity
CH64_RS01630	COG3850	Histidine kinase
CH64_RS01635	COG1294	oxidase, subunit
CH64_RS01640	COG1271	oxidase subunit
CH64_RS01645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_RS01655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CH64_RS01660	COG3138	arginine N-succinyltransferase
CH64_RS01670	COG3724	N-succinylarginine dihydrolase activity
CH64_RS01675	COG2988	succinylglutamate desuccinylase activity
CH64_RS01690	COG1228	amidohydrolase
CH64_RS01700	COG0402	S-adenosylhomocysteine deaminase activity
CH64_RS01715	COG1129	ABC transporter
CH64_RS01720	COG4211	Belongs to the binding-protein-dependent transport system permease family
CH64_RS01725	COG3443	Belongs to the bacterial solute-binding protein 9 family
CH64_RS01735	COG4942	peptidase
CH64_RS01740	COG0346	lactoylglutathione lyase activity
CH64_RS01745	COG0561	phosphatase activity
CH64_RS01750	COG1349	DNA-binding transcription factor activity
CH64_RS01760	COG2197	response regulator
CH64_RS01765	COG0076	glutamate decarboxylase activity
CH64_RS01770	COG0531	amino acid
CH64_RS01775	COG0012	GTP binding
CH64_RS01785	COG0193	aminoacyl-tRNA hydrolase activity
CH64_RS01795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CH64_RS01805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CH64_RS01810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CH64_RS01820	COG2890	protein-(glutamine-N5) methyltransferase activity
CH64_RS01840	COG0659	secondary active sulfate transmembrane transporter activity
CH64_RS01845	COG3706	GGDEF domain
CH64_RS01865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH64_RS01875	COG3381	protein complex oligomerization
CH64_RS01885	COG0477	Major facilitator Superfamily
CH64_RS01890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_RS01900	COG0673	inositol 2-dehydrogenase activity
CH64_RS01905	COG0728	peptidoglycan biosynthetic process
CH64_RS01910	COG0018	arginyl-trna synthetase
CH64_RS01915	COG3102	Protein conserved in bacteria
CH64_RS01920	COG3142	Participates in the control of copper homeostasis
CH64_RS01935	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CH64_RS01940	COG1801	Protein of unknown function DUF72
CH64_RS01945	COG1335	isochorismatase
CH64_RS01950	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CH64_RS01955	COG0494	nUDIX hydrolase
CH64_RS01960	COG0217	transcriptional regulatory protein
CH64_RS01965	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CH64_RS01970	COG0632	four-way junction helicase activity
CH64_RS01975	COG2255	four-way junction helicase activity
CH64_RS01980	COG3104	oligopeptide transport
CH64_RS01985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_RS01990	COG1121	(ABC) transporter
CH64_RS01995	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CH64_RS02000	COG0739	heme binding
CH64_RS02005	COG1560	Kdo2-lipid A biosynthetic process
CH64_RS02010	COG0469	pyruvate kinase activity
CH64_RS02015	COG1737	Transcriptional regulator
CH64_RS02020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CH64_RS02025	COG0800	Aldolase
CH64_RS02030	COG2076	Multidrug Resistance protein
CH64_RS02035	COG2076	Multidrug Resistance protein
CH64_RS02040	COG0251	oxidation-reduction process
CH64_RS02045	COG1199	ATP-dependent helicase activity
CH64_RS02055	COG3065	identical protein binding
CH64_RS02060	COG0318	PFAM AMP-dependent synthetase and ligase
CH64_RS02065	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CH64_RS02070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CH64_RS02075	COG2894	cell division
CH64_RS02080	COG0850	regulation of cytokinetic process
CH64_RS02090	COG3100	YcgL domain-containing protein
CH64_RS02095	COG2951	lytic endotransglycosylase activity
CH64_RS02100	COG0179	Fumarylacetoacetate (FAA) hydrolase
CH64_RS02105	COG2983	Belongs to the UPF0260 family
CH64_RS02115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_RS02120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CH64_RS02125	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH64_RS02130	COG2186	Transcriptional regulator
CH64_RS02135	COG2719	SpoVR family
CH64_RS02140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH64_RS02145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CH64_RS02155	COG2199	diguanylate cyclase activity
CH64_RS02155	COG2200	EAL domain
CH64_RS02155	COG2202	Pas domain
CH64_RS02165	COG0583	DNA-binding transcription factor activity
CH64_RS02175	COG2718	Belongs to the UPF0229 family
CH64_RS02180	COG2766	serine protein kinase
CH64_RS02185	COG3713	MltA-interacting MipA family protein
CH64_RS02205	COG3139	Protein of unknown function (DUF1315)
CH64_RS02210	COG1335	isochorismatase
CH64_RS02215	COG0252	asparaginase activity
CH64_RS02220	COG0616	signal peptide processing
CH64_RS02225	COG0778	Nitroreductase
CH64_RS02235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CH64_RS02245	COG0494	nUDIX hydrolase
CH64_RS02250	COG0708	Exodeoxyribonuclease III
CH64_RS02255	COG0583	DNA-binding transcription factor activity
CH64_RS02270	COG0788	formyltetrahydrofolate deformylase activity
CH64_RS02275	COG3012	SEC-C Motif Domain Protein
CH64_RS02285	COG1752	Esterase of the alpha-beta hydrolase superfamily
CH64_RS02290	COG0745	RESPONSE REGULATOR receiver
CH64_RS02295	COG2916	Histone family protein nucleoid-structuring protein H-NS
CH64_RS02310	COG1454	alcohol dehydrogenase
CH64_RS02310	COG1012	belongs to the aldehyde dehydrogenase family
CH64_RS02315	COG2095	MarC family integral membrane protein
CH64_RS02330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_RS02335	COG0444	Belongs to the ABC transporter superfamily
CH64_RS02345	COG3099	Belongs to the UPF0263 family
CH64_RS02350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH64_RS02355	COG2200	EAL domain
CH64_RS02365	COG2350	Protein conserved in bacteria
CH64_RS02370	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CH64_RS02380	COG2917	probably involved in intracellular septation
CH64_RS02395	COG3047	cAMP biosynthetic process
CH64_RS02415	COG0159	tryptophan synthase activity
CH64_RS02420	COG0133	tryptophan synthase activity
CH64_RS02425	COG0134	indole-3-glycerol-phosphate synthase activity
CH64_RS02425	COG0135	phosphoribosylanthranilate isomerase activity
CH64_RS02435	COG0512	Glutamine amidotransferase of anthranilate synthase
CH64_RS02460	COG1187	pseudouridine synthase activity
CH64_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS02480	COG0616	signal peptide processing
CH64_RS02495	COG0583	DNA-binding transcription factor activity
CH64_RS02515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CH64_RS02525	COG0671	phosphoesterase, PA-phosphatase related
CH64_RS02530	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CH64_RS02535	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CH64_RS02550	COG0284	orotidine-5'-phosphate decarboxylase activity
CH64_RS02555	COG0023	Translation Initiation Factor
CH64_RS02565	COG0235	Class ii aldolase
CH64_RS02575	COG1349	DNA-binding transcription factor activity
CH64_RS02580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH64_RS02585	COG2879	small protein
CH64_RS02590	COG1966	Carbon starvation protein
CH64_RS02595	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CH64_RS02600	COG0243	molybdopterin cofactor binding
CH64_RS02605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CH64_RS02615	COG4659	FMN binding
CH64_RS02620	COG4658	electron transport chain
CH64_RS02625	COG3708	Transcriptional regulator
CH64_RS02625	COG2207	Transcriptional regulator
CH64_RS02640	COG4657	Part of a membrane complex involved in electron transport
CH64_RS02650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CH64_RS02660	COG2274	protein secretion by the type I secretion system
CH64_RS02670	COG2274	protein secretion by the type I secretion system
CH64_RS02685	COG1879	ABC-type sugar transport system periplasmic component
CH64_RS02690	COG1129	ABC transporter
CH64_RS02695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS02705	COG0673	inositol 2-dehydrogenase activity
CH64_RS02710	COG0385	Bile acid
CH64_RS02715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CH64_RS02720	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CH64_RS02725	COG1263	PTS System
CH64_RS02725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS02730	COG1609	Transcriptional regulator
CH64_RS02735	COG5339	Protein conserved in bacteria
CH64_RS02745	COG0114	fumarate hydratase activity
CH64_RS02765	COG2814	Major facilitator Superfamily
CH64_RS02770	COG0583	DNA-binding transcription factor activity
CH64_RS02775	COG1940	carbohydrate kinase activity
CH64_RS02780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CH64_RS02805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH64_RS02810	COG1393	Belongs to the ArsC family
CH64_RS02815	COG1742	UPF0060 membrane protein
CH64_RS02820	COG4221	oxidoreductase activity
CH64_RS02825	COG0477	Major facilitator Superfamily
CH64_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS02880	COG0625	glutathione transferase activity
CH64_RS02890	COG1522	sequence-specific DNA binding
CH64_RS02900	COG4215	(ABC) transporter
CH64_RS02915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH64_RS02935	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH64_RS02945	COG0028	Belongs to the TPP enzyme family
CH64_RS02950	COG0440	acetolactate synthase activity
CH64_RS02960	COG1011	Hydrolase
CH64_RS02970	COG0583	DNA-binding transcription factor activity
CH64_RS02985	COG0738	Major facilitator superfamily
CH64_RS02990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_RS03005	COG3121	Chaperone
CH64_RS03025	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CH64_RS03035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH64_RS03040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CH64_RS03045	COG0589	response to stress
CH64_RS03050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CH64_RS03055	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CH64_RS03070	COG0531	amino acid
CH64_RS03080	COG0745	RESPONSE REGULATOR receiver
CH64_RS03085	COG2205	protein histidine kinase activity
CH64_RS03090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CH64_RS03095	COG0659	secondary active sulfate transmembrane transporter activity
CH64_RS03105	COG3591	Belongs to the peptidase S1B family
CH64_RS03115	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
CH64_RS03120	COG1643	Atp-dependent helicase
CH64_RS03125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CH64_RS03130	COG3784	Protein of unknown function (DUF1318)
CH64_RS03140	COG2911	Protein conserved in bacteria
CH64_RS03145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_RS03150	COG3187	Heat shock protein
CH64_RS03155	COG3042	response to heat
CH64_RS03160	COG1285	pathogenesis
CH64_RS03170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS03170	COG0674	pyruvate-flavodoxin oxidoreductase activity
CH64_RS03170	COG1013	pyruvate-flavodoxin oxidoreductase activity
CH64_RS03170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CH64_RS03195	COG4166	transmembrane transport
CH64_RS03200	COG2866	Carboxypeptidase
CH64_RS03205	COG4948	Mandelate Racemase Muconate Lactonizing
CH64_RS03210	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CH64_RS03220	COG5642	Protein of unknown function (DUF2384)
CH64_RS03225	COG5654	RES domain protein
CH64_RS03230	COG3768	UPF0283 membrane protein
CH64_RS03235	COG3106	COG3106 Predicted ATPase
CH64_RS03245	COG1983	PspC domain protein
CH64_RS03255	COG1842	Phage shock protein A
CH64_RS03260	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CH64_RS03265	COG4166	transmembrane transport
CH64_RS03275	COG4171	peptide transport system, permease
CH64_RS03285	COG4172	Belongs to the ABC transporter superfamily
CH64_RS03295	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH64_RS03295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH64_RS03305	COG3104	oligopeptide transport
CH64_RS03330	COG0625	glutathione transferase activity
CH64_RS03340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CH64_RS03350	COG3895	Periplasmic Protein
CH64_RS03355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CH64_RS03360	COG3133	Outer membrane lipoprotein
CH64_RS03365	COG1846	Transcriptional regulator
CH64_RS03375	COG1566	PFAM secretion protein HlyD family protein
CH64_RS03385	COG4989	oxidoreductase activity
CH64_RS03390	COG3313	Fe-S protein
CH64_RS03395	COG2194	sulfuric ester hydrolase activity
CH64_RS03400	COG1309	transcriptional regulator
CH64_RS03405	COG1902	pentaerythritol trinitrate reductase activity
CH64_RS03410	COG0346	lactoylglutathione lyase activity
CH64_RS03415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH64_RS03420	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CH64_RS03425	COG0791	NLP P60 protein
CH64_RS03440	COG1609	Transcriptional regulator
CH64_RS03450	COG2814	Major facilitator Superfamily
CH64_RS03455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CH64_RS03460	COG0307	riboflavin synthase, alpha
CH64_RS03465	COG0534	Mate efflux family protein
CH64_RS03495	COG1376	ErfK ybiS ycfS ynhG family protein
CH64_RS03495	COG1388	LysM domain
CH64_RS03510	COG0719	Fe-S assembly protein
CH64_RS03515	COG0396	ATPase activity
CH64_RS03520	COG0719	Fe-S assembly protein
CH64_RS03525	COG0316	Belongs to the HesB IscA family
CH64_RS03530	COG2050	protein possibly involved in aromatic compounds catabolism
CH64_RS03535	COG0277	FAD linked oxidase domain protein
CH64_RS03535	COG0247	lactate metabolic process
CH64_RS03540	COG0628	permease
CH64_RS03545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH64_RS03545	COG0574	Belongs to the PEP-utilizing enzyme family
CH64_RS03550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CH64_RS03565	COG4771	TonB-dependent receptor
CH64_RS03570	COG3720	iron ion transport
CH64_RS03575	COG4558	Periplasmic binding protein
CH64_RS03585	COG0095	Lipoate-protein ligase
CH64_RS03590	COG0791	NLP P60 protein
CH64_RS03595	COG2076	Multidrug Resistance protein
CH64_RS03600	COG2076	Multidrug Resistance protein
CH64_RS03605	COG0726	polysaccharide deacetylase
CH64_RS03620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH64_RS03625	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CH64_RS03630	COG0386	Belongs to the glutathione peroxidase family
CH64_RS03635	COG4139	cobalamin transport
CH64_RS03655	COG3122	Protein conserved in bacteria
CH64_RS03660	COG0776	regulation of translation
CH64_RS03680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CH64_RS03685	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CH64_RS03690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CH64_RS03700	COG4249	Peptidase C14 caspase catalytic subunit p20
CH64_RS03705	COG1811	Na channel or pump
CH64_RS03730	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH64_RS03735	COG1121	(ABC) transporter
CH64_RS03740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_RS03745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_RS03750	COG3001	Fructosamine kinase
CH64_RS03755	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH64_RS03755	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH64_RS03760	COG1703	isobutyryl-CoA mutase activity
CH64_RS03765	COG1024	Enoyl-CoA hydratase
CH64_RS03770	COG0427	acetyl-CoA hydrolase
CH64_RS03775	COG0583	DNA-binding transcription factor activity
CH64_RS03785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_RS03790	COG1917	Cupin 2, conserved barrel domain protein
CH64_RS03795	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CH64_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS03810	COG1175	transmembrane transport
CH64_RS03815	COG0395	ABC-type sugar transport system, permease component
CH64_RS03820	COG3842	ATPase activity
CH64_RS03825	COG1653	transport
CH64_RS03830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH64_RS03835	COG1988	membrane-bound metal-dependent
CH64_RS03840	COG1823	symporter activity
CH64_RS03845	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH64_RS03855	COG0823	Involved in the tonB-independent uptake of proteins
CH64_RS03860	COG2814	Major facilitator Superfamily
CH64_RS03870	COG0501	Belongs to the peptidase M48B family
CH64_RS03875	COG0793	Belongs to the peptidase S41A family
CH64_RS03885	COG1956	GAF domain-containing protein
CH64_RS03890	COG2995	paraquat-inducible protein a
CH64_RS03895	COG3008	intermembrane lipid transfer
CH64_RS03900	COG2203	Gaf domain
CH64_RS03900	COG3706	GGDEF domain
CH64_RS03900	COG4251	negative regulation of phosphorylation
CH64_RS03900	COG5001	Diguanylate cyclase
CH64_RS03925	COG0625	glutathione transferase activity
CH64_RS03940	COG0786	glutamate:sodium symporter activity
CH64_RS04015	COG2169	Transcriptional regulator
CH64_RS04015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH64_RS04020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CH64_RS04035	COG3772	lysozyme
CH64_RS04065	COG1276	copper resistance
CH64_RS04070	COG2372	response to copper ion
CH64_RS04075	COG1528	Iron-storage protein
CH64_RS04090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CH64_RS04095	COG1770	oligopeptidase
CH64_RS04105	COG3097	Belongs to the UPF0267 family
CH64_RS04110	COG3141	response to X-ray
CH64_RS04115	COG0513	Belongs to the DEAD box helicase family
CH64_RS04120	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CH64_RS04125	COG3140	Belongs to the UPF0181 family
CH64_RS04135	COG0494	nUDIX hydrolase
CH64_RS04140	COG1760	l-serine dehydratase
CH64_RS04145	COG1253	flavin adenine dinucleotide binding
CH64_RS04150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS04150	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS04155	COG3715	PTS system
CH64_RS04160	COG3716	PTS system mannose fructose sorbose family IID component
CH64_RS04170	COG1971	Probably functions as a manganese efflux pump
CH64_RS04185	COG2226	methyltransferase
CH64_RS04190	COG1496	oxidoreductase activity
CH64_RS04210	COG1113	amino acid transport
CH64_RS04245	COG2207	Transcriptional regulator
CH64_RS04270	COG1132	(ABC) transporter
CH64_RS04280	COG2721	sulfolactate sulfo-lyase activity
CH64_RS04285	COG2271	Major facilitator Superfamily
CH64_RS04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH64_RS04300	COG3706	GGDEF domain
CH64_RS04300	COG4251	negative regulation of phosphorylation
CH64_RS04300	COG5001	Diguanylate cyclase
CH64_RS04300	COG2203	Gaf domain
CH64_RS04310	COG3755	Protein conserved in bacteria
CH64_RS04320	COG0697	spore germination
CH64_RS04330	COG1733	regulation of RNA biosynthetic process
CH64_RS04335	COG0702	epimerase
CH64_RS04340	COG2873	o-acetylhomoserine
CH64_RS04345	COG1566	PFAM secretion protein HlyD family protein
CH64_RS04360	COG0840	transmembrane signaling receptor activity
CH64_RS04380	COG2223	nitrite transmembrane transporter activity
CH64_RS04395	COG0538	isocitrate dehydrogenase activity
CH64_RS04400	COG1187	pseudouridine synthase activity
CH64_RS04410	COG0482	sulfurtransferase activity
CH64_RS04415	COG2915	High frequency lysogenization protein hflD homolog
CH64_RS04420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CH64_RS04430	COG0745	RESPONSE REGULATOR receiver
CH64_RS04440	COG2850	peptidyl-arginine hydroxylation
CH64_RS04455	COG1940	carbohydrate kinase activity
CH64_RS04460	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH64_RS04470	COG4591	ABC-type transport system involved in lipoprotein release permease component
CH64_RS04475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CH64_RS04480	COG3134	Outer membrane lipoprotein
CH64_RS04485	COG1252	NADH dehydrogenase
CH64_RS04500	COG1472	Belongs to the glycosyl hydrolase 3 family
CH64_RS04510	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CH64_RS04515	COG5633	Lipoprotein
CH64_RS04520	COG0537	adenosine 5'-monophosphoramidase activity
CH64_RS04525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH64_RS04535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS04535	COG1263	PTS System
CH64_RS04540	COG0084	hydrolase, TatD family'
CH64_RS04545	COG0470	DNA polymerase III
CH64_RS04550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CH64_RS04555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CH64_RS04560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH64_RS04565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH64_RS04590	COG0416	fatty acid biosynthetic process
CH64_RS04595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CH64_RS04600	COG1399	metal-binding, possibly nucleic acid-binding protein
CH64_RS04610	COG0564	pseudouridine synthase activity
CH64_RS04615	COG1530	ribonuclease E activity
CH64_RS04615	COG1530	ribonuclease E activity
CH64_RS04620	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH64_RS04625	COG0418	dihydroorotase activity
CH64_RS04650	COG0628	permease
CH64_RS04655	COG1054	Belongs to the UPF0176 family
CH64_RS04690	COG1560	Kdo2-lipid A biosynthetic process
CH64_RS04695	COG2259	Doxx family
CH64_RS04700	COG2814	Major facilitator Superfamily
CH64_RS04715	COG5645	(Lipo)protein
CH64_RS04720	COG2943	transferase activity, transferring hexosyl groups
CH64_RS04725	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CH64_RS04740	COG3263	regulation of cellular component size
CH64_RS04745	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CH64_RS04755	COG3916	Acyl-homoserine-lactone synthase
CH64_RS04760	COG2771	luxR family
CH64_RS04770	COG4235	cytochrome complex assembly
CH64_RS04775	COG4235	cytochrome complex assembly
CH64_RS04775	COG3088	subunit of a heme lyase
CH64_RS04780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH64_RS04785	COG1138	Cytochrome C-type biogenesis protein
CH64_RS04790	COG3301	Polysulphide reductase, NrfD
CH64_RS04795	COG0437	4 iron, 4 sulfur cluster binding
CH64_RS04800	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CH64_RS04820	COG2920	part of a sulfur-relay system
CH64_RS04825	COG1254	Belongs to the acylphosphatase family
CH64_RS04830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH64_RS04835	COG3785	DNA binding
CH64_RS04840	COG1832	CoA-binding protein
CH64_RS04850	COG1803	Methylglyoxal synthase
CH64_RS04855	COG0210	DNA helicase
CH64_RS04860	COG3304	Inner membrane component domain
CH64_RS04865	COG1289	transmembrane transporter activity
CH64_RS04870	COG3070	regulator of competence-specific genes
CH64_RS04875	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
CH64_RS04885	COG3120	sequence-specific DNA binding
CH64_RS04890	COG1067	ATP-dependent peptidase activity
CH64_RS04895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH64_RS04905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH64_RS04910	COG3009	Protein conserved in bacteria
CH64_RS04915	COG3008	intermembrane lipid transfer
CH64_RS04915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH64_RS04920	COG2995	paraquat-inducible protein a
CH64_RS04925	COG0488	(ABC) transporter
CH64_RS04930	COG0116	Belongs to the methyltransferase superfamily
CH64_RS04930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CH64_RS04935	COG3217	Mosc domain protein beta barrel domain protein
CH64_RS04935	COG0633	Ferredoxin
CH64_RS04945	COG0167	dihydroorotate dehydrogenase activity
CH64_RS04950	COG0308	aminopeptidase N
CH64_RS04955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CH64_RS04960	COG0017	Asparaginyl-tRNA synthetase
CH64_RS04970	COG1448	Aminotransferase
CH64_RS04975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH64_RS04980	COG3108	Peptidase M15
CH64_RS04985	COG2989	Protein conserved in bacteria
CH64_RS04990	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CH64_RS05000	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
CH64_RS05010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CH64_RS05015	COG3173	Aminoglycoside phosphotransferase
CH64_RS05025	COG2835	tetraacyldisaccharide 4'-kinase activity
CH64_RS05030	COG1278	Cold shock
CH64_RS05040	COG5383	Protein conserved in bacteria
CH64_RS05045	COG1663	tetraacyldisaccharide 4'-kinase activity
CH64_RS05055	COG0658	competence protein
CH64_RS05055	COG2333	competence protein COMEC
CH64_RS05060	COG0776	regulation of translation
CH64_RS05065	COG0539	negative regulation of cytoplasmic translation
CH64_RS05070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CH64_RS05075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CH64_RS05080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CH64_RS05085	COG2323	membrane
CH64_RS05090	COG0252	asparaginase activity
CH64_RS05095	COG1944	ATP diphosphatase activity
CH64_RS05100	COG2116	formate transmembrane transporter activity
CH64_RS05105	COG1882	Formate acetyltransferase
CH64_RS05110	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH64_RS05115	COG2814	Major facilitator Superfamily
CH64_RS05120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CH64_RS05125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CH64_RS05130	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CH64_RS05135	COG1674	ftsk spoiiie
CH64_RS05135	COG3107	peptidoglycan biosynthetic process
CH64_RS05145	COG0492	ferredoxin-NADP+ reductase activity
CH64_RS05155	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CH64_RS05165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CH64_RS05170	COG0542	response to heat
CH64_RS05175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CH64_RS05180	COG1278	Cold shock
CH64_RS05190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS05195	COG2990	Protein conserved in bacteria
CH64_RS05200	COG3593	DNA synthesis involved in DNA repair
CH64_RS05205	COG2431	L-lysine efflux transmembrane transporter activity
CH64_RS05210	COG1151	hydroxylamine reductase activity
CH64_RS05215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH64_RS05220	COG0028	Belongs to the TPP enzyme family
CH64_RS05230	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CH64_RS05235	COG0702	epimerase
CH64_RS05240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH64_RS05250	COG1126	abc transporter atp-binding protein
CH64_RS05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS05260	COG4215	(ABC) transporter
CH64_RS05265	COG4160	amino acid transport
CH64_RS05270	COG2271	Major facilitator Superfamily
CH64_RS05275	COG2186	Transcriptional regulator
CH64_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS05295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH64_RS05305	COG1177	transmembrane transport
CH64_RS05310	COG1176	ABC-type spermidine putrescine transport system, permease component I
CH64_RS05315	COG3842	ATPase activity
CH64_RS05320	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CH64_RS05340	COG0569	domain protein
CH64_RS05340	COG2985	domain, Protein
CH64_RS05395	COG0671	phosphoesterase, PA-phosphatase related
CH64_RS05400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CH64_RS05405	COG1349	DNA-binding transcription factor activity
CH64_RS05410	COG0814	amino acid
CH64_RS05415	COG1760	l-serine dehydratase
CH64_RS05420	COG1686	Belongs to the peptidase S11 family
CH64_RS05430	COG0626	cystathionine gamma-synthase activity
CH64_RS05435	COG2011	ABC-type metal ion transport system permease component
CH64_RS05460	COG0625	glutathione transferase activity
CH64_RS05465	COG4771	TonB-dependent receptor
CH64_RS05470	COG0833	amino acid
CH64_RS05475	COG0583	DNA-binding transcription factor activity
CH64_RS05480	COG2855	membrane
CH64_RS05485	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CH64_RS05490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH64_RS05490	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CH64_RS05490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CH64_RS05495	COG1105	Belongs to the carbohydrate kinase PfkB family
CH64_RS05520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH64_RS05530	COG0246	Mannitol dehydrogenase
CH64_RS05535	COG2186	Transcriptional regulator
CH64_RS05545	COG0523	cobalamin synthesis protein
CH64_RS05550	COG0671	phosphoesterase, PA-phosphatase related
CH64_RS05555	COG0791	NLP P60 protein
CH64_RS05560	COG2200	EAL domain
CH64_RS05565	COG4166	transmembrane transport
CH64_RS05570	COG4174	ABC transporter (Permease)
CH64_RS05575	COG4239	(ABC) transporter, permease
CH64_RS05580	COG4172	Belongs to the ABC transporter superfamily
CH64_RS05590	COG2814	Major facilitator Superfamily
CH64_RS05595	COG1187	pseudouridine synthase activity
CH64_RS05600	COG1061	Type III restriction enzyme res subunit
CH64_RS05610	COG3081	Nucleoid-associated protein
CH64_RS05615	COG3082	Protein of unknown function (DUF1414)
CH64_RS05630	COG2723	6-phospho-beta-galactosidase activity
CH64_RS05635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS05635	COG1263	PTS System
CH64_RS05635	COG2190	(PTS) system
CH64_RS05640	COG1737	Transcriptional regulator
CH64_RS05665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CH64_RS05680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CH64_RS05690	COG2223	nitrite transmembrane transporter activity
CH64_RS05695	COG2198	Histidine kinase
CH64_RS05695	COG0642	Histidine kinase
CH64_RS05705	COG0784	Response regulator, receiver
CH64_RS05705	COG2205	protein histidine kinase activity
CH64_RS05715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH64_RS05720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH64_RS05730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH64_RS05735	COG4574	serine-type endopeptidase inhibitor activity
CH64_RS05745	COG0814	amino acid
CH64_RS05765	COG1441	menaquinone biosynthetic process
CH64_RS05770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CH64_RS05780	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CH64_RS05785	COG1169	isochorismate synthase
CH64_RS05795	COG4575	ribosome binding
CH64_RS05800	COG0129	dihydroxy-acid dehydratase activity
CH64_RS05805	COG4702	Belongs to the UPF0303 family
CH64_RS05815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_RS05820	COG1609	Transcriptional regulator
CH64_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS05830	COG3265	gluconokinase activity
CH64_RS05835	COG2731	YhcH YjgK YiaL family protein
CH64_RS05850	COG1007	ATP synthesis coupled electron transport
CH64_RS05855	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS05860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CH64_RS05865	COG0713	ATP synthesis coupled electron transport
CH64_RS05870	COG0839	Belongs to the complex I subunit 6 family
CH64_RS05875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS05880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CH64_RS05885	COG1034	ATP synthesis coupled electron transport
CH64_RS05900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS05900	COG0649	NAD binding
CH64_RS05905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS05910	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CH64_RS05915	COG0583	DNA-binding transcription factor activity
CH64_RS05920	COG0436	Aminotransferase
CH64_RS05925	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CH64_RS05930	COG0490	domain, Protein
CH64_RS05930	COG0471	metal ion transport
CH64_RS05940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_RS05945	COG3013	Belongs to the UPF0304 family
CH64_RS05950	COG3092	negative regulation of chromosome organization
CH64_RS05960	COG0857	belongs to the CobB CobQ family
CH64_RS05960	COG0280	phosphate acetyltransferase
CH64_RS05965	COG1609	Transcriptional regulator
CH64_RS05970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS05980	COG3037	sugar-specific permease SgaT UlaA
CH64_RS05985	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CH64_RS05990	COG0622	Phosphoesterase
CH64_RS06000	COG1090	epimerase
CH64_RS06005	COG4598	ABC transporter
CH64_RS06010	COG4160	amino acid transport
CH64_RS06015	COG4215	(ABC) transporter
CH64_RS06020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS06030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CH64_RS06035	COG1286	toxin biosynthetic process
CH64_RS06040	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CH64_RS06045	COG0285	dihydrofolate synthase activity
CH64_RS06050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CH64_RS06055	COG0586	Pfam SNARE associated Golgi protein
CH64_RS06065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH64_RS06070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH64_RS06080	COG0697	spore germination
CH64_RS06090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_RS06095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH64_RS06120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CH64_RS06140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH64_RS06145	COG2723	6-phospho-beta-galactosidase activity
CH64_RS06150	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH64_RS06160	COG1794	racemase activity, acting on amino acids and derivatives
CH64_RS06170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CH64_RS06175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CH64_RS06175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CH64_RS06185	COG3101	peptidyl-lysine hydroxylation
CH64_RS06190	COG0730	response to heat
CH64_RS06195	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CH64_RS06200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CH64_RS06205	COG2890	protein-(glutamine-N5) methyltransferase activity
CH64_RS06210	COG2840	Smr protein MutS2
CH64_RS06215	COG2062	phosphohistidine phosphatase, SixA
CH64_RS06220	COG1024	Enoyl-CoA hydratase
CH64_RS06220	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH64_RS06225	COG0183	Belongs to the thiolase family
CH64_RS06230	COG3691	Protein conserved in bacteria
CH64_RS06245	COG4235	cytochrome complex assembly
CH64_RS06245	COG3088	subunit of a heme lyase
CH64_RS06250	COG4235	cytochrome complex assembly
CH64_RS06250	COG3088	subunit of a heme lyase
CH64_RS06255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CH64_RS06260	COG1138	Cytochrome C-type biogenesis protein
CH64_RS06265	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CH64_RS06270	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH64_RS06275	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH64_RS06280	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CH64_RS06290	COG2116	formate transmembrane transporter activity
CH64_RS06300	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CH64_RS06305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_RS06315	COG4948	Mandelate Racemase Muconate Lactonizing
CH64_RS06320	COG0800	Aldolase
CH64_RS06325	COG3734	2-keto-3-deoxy-galactonokinase
CH64_RS06330	COG2186	Transcriptional regulator
CH64_RS06335	COG2824	Alkylphosphonate utilization operon protein PhnA
CH64_RS06340	COG1695	Transcriptional regulator
CH64_RS06350	COG2723	6-phospho-beta-galactosidase activity
CH64_RS06355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS06355	COG1263	PTS System
CH64_RS06365	COG0583	DNA-binding transcription factor activity
CH64_RS06370	COG2197	response regulator
CH64_RS06375	COG1609	Transcriptional regulator
CH64_RS06380	COG2353	YceI-like domain
CH64_RS06385	COG3038	cytochrome b561
CH64_RS06400	COG1127	ABC transporter
CH64_RS06405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH64_RS06425	COG0531	amino acid
CH64_RS06430	COG2951	lytic endotransglycosylase activity
CH64_RS06455	COG0243	molybdopterin cofactor binding
CH64_RS06460	COG0437	4 iron, 4 sulfur cluster binding
CH64_RS06465	COG3302	dmso reductase anchor subunit
CH64_RS06470	COG3381	protein complex oligomerization
CH64_RS06480	COG3038	cytochrome b561
CH64_RS06485	COG0436	Aminotransferase
CH64_RS06490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_RS06500	COG3275	phosphorelay sensor kinase activity
CH64_RS06505	COG3279	Response regulator of the LytR AlgR family
CH64_RS06510	COG2223	nitrite transmembrane transporter activity
CH64_RS06515	COG0837	glucose binding
CH64_RS06530	COG3961	Belongs to the TPP enzyme family
CH64_RS06535	COG0667	Aldo Keto reductase
CH64_RS06545	COG1914	H( )-stimulated, divalent metal cation uptake system
CH64_RS06550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH64_RS06555	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CH64_RS06560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_RS06560	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_RS06565	COG0583	DNA-binding transcription factor activity
CH64_RS06570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH64_RS06570	COG1648	precorrin-2 dehydrogenase activity
CH64_RS06580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CH64_RS06590	COG4865	methylaspartate mutase activity
CH64_RS06595	COG3799	methylaspartate ammonia-lyase activity
CH64_RS06610	COG1301	dicarboxylic acid transport
CH64_RS06635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH64_RS06665	COG3530	Putative quorum-sensing-regulated virulence factor
CH64_RS06690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS06705	COG2205	protein histidine kinase activity
CH64_RS06710	COG0745	RESPONSE REGULATOR receiver
CH64_RS06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS06735	COG4208	sulfate ABC transporter
CH64_RS06740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CH64_RS06745	COG4150	thiosulfate binding
CH64_RS06755	COG1737	Transcriptional regulator
CH64_RS06760	COG2731	YhcH YjgK YiaL family protein
CH64_RS06775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH64_RS06780	COG2837	iron assimilation
CH64_RS06790	COG3111	PFAM Bacterial OB fold (BOF) protein
CH64_RS06795	COG0456	acetyltransferase
CH64_RS06800	COG0408	coproporphyrinogen oxidase activity
CH64_RS06815	COG0494	nUDIX hydrolase
CH64_RS06830	COG3005	denitrification pathway
CH64_RS06835	COG3043	anaerobic respiration
CH64_RS06840	COG0243	molybdopterin cofactor binding
CH64_RS06845	COG3062	negative regulation of establishment of protein localization
CH64_RS06850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_RS06855	COG2197	response regulator
CH64_RS06865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_RS06875	COG1393	Belongs to the ArsC family
CH64_RS06880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH64_RS06885	COG1876	peptidase activity
CH64_RS06895	COG0400	carboxylic ester hydrolase activity
CH64_RS06900	COG1444	tRNA N-acetyltransferase activity
CH64_RS06905	COG2707	UPF0756 membrane protein
CH64_RS06910	COG2321	neutral zinc metallopeptidase
CH64_RS06915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CH64_RS06920	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CH64_RS06925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CH64_RS06930	COG2716	regulation of RNA biosynthetic process
CH64_RS06935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CH64_RS06940	COG0628	permease
CH64_RS06945	COG4783	chaperone-mediated protein folding
CH64_RS06950	COG1393	Belongs to the ArsC family
CH64_RS06955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CH64_RS06960	COG2233	PERMEase
CH64_RS06965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CH64_RS06975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CH64_RS06980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_RS07000	COG0581	inorganic phosphate transmembrane transporter activity
CH64_RS07005	COG0573	inorganic phosphate transmembrane transporter activity
CH64_RS07010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CH64_RS07015	COG0248	Ppx GppA phosphatase
CH64_RS07025	COG2239	Acts as a magnesium transporter
CH64_RS07030	COG3447	MASE1 domain protein
CH64_RS07030	COG5001	Diguanylate cyclase
CH64_RS07030	COG5002	protein histidine kinase activity
CH64_RS07035	COG0443	Heat shock 70 kDa protein
CH64_RS07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS07050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_RS07055	COG0477	Major facilitator Superfamily
CH64_RS07060	COG2205	protein histidine kinase activity
CH64_RS07065	COG0745	RESPONSE REGULATOR receiver
CH64_RS07070	COG3422	double-strand break repair
CH64_RS07075	COG0826	peptidase U32
CH64_RS07080	COG1597	lipid kinase activity
CH64_RS07085	COG3730	PTS system glucitol sorbitol-specific
CH64_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS07105	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS07110	COG1349	DNA-binding transcription factor activity
CH64_RS07130	COG0351	phosphomethylpyrimidine kinase
CH64_RS07145	COG0519	Catalyzes the synthesis of GMP from XMP
CH64_RS07145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CH64_RS07150	COG0516	GMP reductase activity
CH64_RS07150	COG0517	IMP dehydrogenase activity
CH64_RS07155	COG1570	exodeoxyribonuclease VII activity
CH64_RS07160	COG1645	bacterial-type flagellum-dependent swarming motility
CH64_RS07170	COG1160	GTP binding
CH64_RS07175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH64_RS07180	COG2976	Protein conserved in bacteria
CH64_RS07185	COG0124	histidyl-tRNA synthetase
CH64_RS07190	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CH64_RS07195	COG1426	Protein conserved in bacteria
CH64_RS07205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CH64_RS07215	COG4953	penicillin-binding protein 1C
CH64_RS07220	COG2373	Large extracellular alpha-helical protein
CH64_RS07230	COG0243	molybdopterin cofactor binding
CH64_RS07235	COG3468	outer membrane autotransporter barrel domain protein
CH64_RS07255	COG2975	iron-sulfur cluster assembly
CH64_RS07260	COG0633	Ferredoxin
CH64_RS07265	COG0443	Heat shock 70 kDa protein
CH64_RS07270	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CH64_RS07280	COG0822	iron-sulfur transferase activity
CH64_RS07285	COG1104	cysteine desulfurase activity
CH64_RS07290	COG1959	2 iron, 2 sulfur cluster binding
CH64_RS07295	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CH64_RS07305	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CH64_RS07310	COG3683	transport system, periplasmic component
CH64_RS07315	COG3711	transcriptional antiterminator
CH64_RS07320	COG2814	Major facilitator Superfamily
CH64_RS07325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CH64_RS07330	COG1017	nitric oxide dioxygenase activity
CH64_RS07330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CH64_RS07335	COG2188	Transcriptional regulator
CH64_RS07340	COG0347	Belongs to the P(II) protein family
CH64_RS07345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH64_RS07345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CH64_RS07350	COG2204	response regulator
CH64_RS07355	COG3170	Tfp pilus assembly protein FimV
CH64_RS07360	COG2205	protein histidine kinase activity
CH64_RS07375	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CH64_RS07385	COG0560	Phosphoserine phosphatase
CH64_RS07395	COG1737	Transcriptional regulator
CH64_RS07400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CH64_RS07405	COG2610	gluconate transmembrane transporter activity
CH64_RS07410	COG0736	holo-[acyl-carrier-protein] synthase activity
CH64_RS07415	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CH64_RS07420	COG1381	Involved in DNA repair and RecF pathway recombination
CH64_RS07425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CH64_RS07440	COG0481	GTPase activity
CH64_RS07450	COG3086	response to oxidative stress
CH64_RS07455	COG3026	antisigma factor binding
CH64_RS07460	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CH64_RS07470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CH64_RS07475	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CH64_RS07480	COG0513	Belongs to the DEAD box helicase family
CH64_RS07490	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CH64_RS07495	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CH64_RS07500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CH64_RS07505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CH64_RS07510	COG0497	DNA recombination
CH64_RS07515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH64_RS07525	COG2867	negative regulation of translational initiation
CH64_RS07530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CH64_RS07535	COG0582	viral genome integration into host DNA
CH64_RS07550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CH64_RS07575	COG0210	DNA helicase
CH64_RS07615	COG3596	GTP binding
CH64_RS07620	COG2378	regulation of single-species biofilm formation
CH64_RS07640	COG2003	Belongs to the UPF0758 family
CH64_RS07690	COG3394	polysaccharide catabolic process
CH64_RS07695	COG2169	Transcriptional regulator
CH64_RS07695	COG1917	Cupin 2, conserved barrel domain protein
CH64_RS07700	COG1447	Phosphotransferase system cellobiose-specific component IIA
CH64_RS07705	COG2723	6-phospho-beta-galactosidase activity
CH64_RS07710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH64_RS07715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CH64_RS07720	COG2133	pyrroloquinoline quinone binding
CH64_RS07725	COG0667	Aldo Keto reductase
CH64_RS07740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH64_RS07750	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CH64_RS07755	COG4413	Urea transporter
CH64_RS07760	COG0829	nickel cation binding
CH64_RS07765	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH64_RS07770	COG0830	nickel cation binding
CH64_RS07780	COG0804	urea catabolic process
CH64_RS07785	COG0832	Belongs to the urease beta subunit family
CH64_RS07805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_RS07830	COG1278	Cold shock
CH64_RS07860	COG4575	ribosome binding
CH64_RS07870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CH64_RS07880	COG1780	Probably involved in ribonucleotide reductase function
CH64_RS07890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CH64_RS07895	COG4175	Glycine betaine
CH64_RS07900	COG4176	ABC-type proline glycine betaine transport system permease component
CH64_RS07905	COG2113	Glycine betaine
CH64_RS07925	COG2226	methyltransferase
CH64_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CH64_RS07935	COG0741	lytic transglycosylase activity
CH64_RS07935	COG1388	LysM domain
CH64_RS07940	COG3021	interspecies interaction between organisms
CH64_RS07945	COG2814	Major facilitator Superfamily
CH64_RS07950	COG0583	DNA-binding transcription factor activity
CH64_RS07955	COG0656	L-ascorbic acid biosynthetic process
CH64_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS08020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH64_RS08025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CH64_RS08075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CH64_RS08085	COG2011	ABC-type metal ion transport system permease component
CH64_RS08090	COG1464	Belongs to the NlpA lipoprotein family
CH64_RS08100	COG1720	tRNA m6t6A37 methyltransferase activity
CH64_RS08105	COG0442	prolyl-tRNA aminoacylation
CH64_RS08110	COG3015	lipoprotein NlpE involved in copper resistance
CH64_RS08120	COG4681	YaeQ
CH64_RS08130	COG4568	rho-dependent transcription termination
CH64_RS08145	COG0346	lactoylglutathione lyase activity
CH64_RS08150	COG0825	malonyl-CoA metabolic process
CH64_RS08155	COG0587	DNA-directed DNA polymerase activity
CH64_RS08160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CH64_RS08170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_RS08175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CH64_RS08180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_RS08185	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CH64_RS08195	COG0750	zinc metalloprotease
CH64_RS08200	COG0575	Belongs to the CDS family
CH64_RS08210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CH64_RS08215	COG0233	cytoplasmic translational termination
CH64_RS08220	COG0528	UMP kinase activity
CH64_RS08230	COG0052	Belongs to the universal ribosomal protein uS2 family
CH64_RS08240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CH64_RS08245	COG2171	N-acyltransferase activity
CH64_RS08260	COG0564	pseudouridine synthase activity
CH64_RS08265	COG3098	single-species biofilm formation
CH64_RS08275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH64_RS08275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CH64_RS08280	COG1611	Belongs to the LOG family
CH64_RS08285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH64_RS08290	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CH64_RS08295	COG2363	Small membrane protein
CH64_RS08300	COG0583	DNA-binding transcription factor activity
CH64_RS08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CH64_RS08315	COG2166	iron-sulfur cluster assembly
CH64_RS08320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CH64_RS08325	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CH64_RS08345	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH64_RS08350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CH64_RS08350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CH64_RS08355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CH64_RS08360	COG1074	ATP-dependent DNA helicase activity
CH64_RS08365	COG1025	Belongs to the peptidase M16 family
CH64_RS08370	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CH64_RS08400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CH64_RS08410	COG1051	belongs to the nudix hydrolase family
CH64_RS08415	COG3066	DNA modification
CH64_RS08420	COG0861	Integral membrane protein TerC family
CH64_RS08425	COG0667	Aldo Keto reductase
CH64_RS08430	COG0477	Major facilitator Superfamily
CH64_RS08435	COG0318	PFAM AMP-dependent synthetase and ligase
CH64_RS08435	COG0204	Acyl-transferase
CH64_RS08445	COG1609	Transcriptional regulator
CH64_RS08455	COG0583	DNA-binding transcription factor activity
CH64_RS08460	COG2814	Major facilitator Superfamily
CH64_RS08465	COG0583	DNA-binding transcription factor activity
CH64_RS08495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CH64_RS08520	COG2165	general secretion pathway protein
CH64_RS08525	COG2165	general secretion pathway protein
CH64_RS08535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH64_RS08555	COG0288	reversible hydration of carbon dioxide
CH64_RS08565	COG0484	heat shock protein binding
CH64_RS08570	COG1609	Transcriptional regulator
CH64_RS08575	COG2271	Major facilitator Superfamily
CH64_RS08590	COG1522	sequence-specific DNA binding
CH64_RS08595	COG3706	GGDEF domain
CH64_RS08610	COG1470	cell adhesion involved in biofilm formation
CH64_RS08610	COG1388	LysM domain
CH64_RS08630	COG2197	response regulator
CH64_RS08635	COG0791	NLP P60 protein
CH64_RS08640	COG2963	transposase activity
CH64_RS08660	COG3188	usher protein
CH64_RS08705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CH64_RS08710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CH64_RS08715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH64_RS08720	COG4974	Belongs to the 'phage' integrase family
CH64_RS08725	COG0716	FMN binding
CH64_RS08740	COG0354	folic acid binding
CH64_RS08750	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CH64_RS08770	COG1272	protein, Hemolysin III
CH64_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS08780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH64_RS08780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CH64_RS08790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CH64_RS08795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH64_RS08800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH64_RS08805	COG0006	proline dipeptidase activity
CH64_RS08810	COG3079	Belongs to the UPF0149 family
CH64_RS08815	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CH64_RS08820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CH64_RS08825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CH64_RS08830	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CH64_RS08835	COG0583	DNA-binding transcription factor activity
CH64_RS08845	COG1279	arginine transmembrane transporter activity
CH64_RS08860	COG0191	fructose-bisphosphate aldolase activity
CH64_RS08870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CH64_RS08875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CH64_RS08880	COG0501	Belongs to the peptidase M48B family
CH64_RS08885	COG2146	nitrite reductase [NAD(P)H] activity
CH64_RS08890	COG1166	arginine decarboxylase activity
CH64_RS08915	COG0640	Transcriptional regulator
CH64_RS08920	COG3091	SprT-like family
CH64_RS08925	COG2356	endonuclease I
CH64_RS08930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CH64_RS08935	COG0189	ligase activity
CH64_RS08945	COG1678	Uncharacterized ACR, COG1678
CH64_RS08950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CH64_RS08955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH64_RS08965	COG2805	Type II/IV secretion system protein
CH64_RS08970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CH64_RS08975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CH64_RS08980	COG0762	integral membrane protein
CH64_RS08985	COG1872	DUF167
CH64_RS08990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CH64_RS08995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH64_RS09010	COG3171	Protein conserved in bacteria
CH64_RS09015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CH64_RS09020	COG1194	a g-specific adenine glycosylase
CH64_RS09030	COG0741	lytic transglycosylase activity
CH64_RS09035	COG1982	Orn Lys Arg decarboxylase major
CH64_RS09060	COG0791	NLP P60 protein
CH64_RS09145	COG3210	domain, Protein
CH64_RS09175	COG3210	domain, Protein
CH64_RS09180	COG2831	hemolysin activation secretion protein
CH64_RS09200	COG1012	belongs to the aldehyde dehydrogenase family
CH64_RS09205	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CH64_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS09225	COG2271	Major facilitator Superfamily
CH64_RS09240	COG1414	Transcriptional regulator
CH64_RS09260	COG2146	nitrite reductase [NAD(P)H] activity
CH64_RS09310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CH64_RS09400	COG0642	Histidine kinase
CH64_RS09405	COG3477	response to acidic pH
CH64_RS09410	COG1609	Transcriptional regulator
CH64_RS09420	COG2211	Major facilitator Superfamily
CH64_RS09435	COG1289	transmembrane transporter activity
CH64_RS09460	COG0024	Methionine aminopeptidase
CH64_RS09465	COG4604	ABC transporter, ATP-binding protein
CH64_RS09470	COG4605	iron ion homeostasis
CH64_RS09480	COG4607	ABC-type enterochelin transport system periplasmic component
CH64_RS09490	COG0477	Major facilitator Superfamily
CH64_RS09495	COG1609	Transcriptional regulator
CH64_RS09505	COG1283	sodium-dependent phosphate transmembrane transporter activity
CH64_RS09530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS09535	COG5001	Diguanylate cyclase
CH64_RS09540	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CH64_RS09550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CH64_RS09555	COG0309	Hydrogenase expression formation protein (HypE)
CH64_RS09560	COG0409	Hydrogenase expression formation protein
CH64_RS09565	COG0298	carbon dioxide binding
CH64_RS09570	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CH64_RS09580	COG1773	rubredoxin
CH64_RS09585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CH64_RS09590	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CH64_RS09595	COG5557	Pfam Polysulphide reductase, NrfD
CH64_RS09600	COG0437	4 iron, 4 sulfur cluster binding
CH64_RS09605	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CH64_RS09615	COG3133	Outer membrane lipoprotein
CH64_RS09625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CH64_RS09630	COG1191	sigma factor activity
CH64_RS09655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CH64_RS09660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_RS09665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_RS09670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_RS09690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CH64_RS09705	COG1706	bacterial-type flagellum-dependent cell motility
CH64_RS09715	COG4786	Flagellar basal body rod
CH64_RS09730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CH64_RS09735	COG1558	bacterial-type flagellum-dependent cell motility
CH64_RS09785	COG1677	Flagellar hook-basal body complex protein FliE
CH64_RS09810	COG1987	bacterial-type flagellum assembly
CH64_RS09820	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CH64_RS09835	COG0840	transmembrane signaling receptor activity
CH64_RS09840	COG4592	Periplasmic binding protein
CH64_RS09845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_RS09850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_RS09855	COG1120	ATPase activity
CH64_RS09880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS09885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_RS09910	COG4964	Belongs to the GSP D family
CH64_RS09960	COG0848	biopolymer transport protein
CH64_RS09970	COG0626	cystathionine gamma-synthase activity
CH64_RS09975	COG0586	Pfam SNARE associated Golgi protein
CH64_RS09980	COG2207	Transcriptional regulator
CH64_RS09985	COG1979	alcohol dehydrogenase
CH64_RS09990	COG0656	L-ascorbic acid biosynthetic process
CH64_RS10000	COG2132	Multicopper oxidase
CH64_RS10010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CH64_RS10015	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH64_RS10020	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH64_RS10035	COG3150	esterase
CH64_RS10040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CH64_RS10045	COG3151	Protein conserved in bacteria
CH64_RS10050	COG0494	nUDIX hydrolase
CH64_RS10060	COG1538	Outer membrane efflux protein
CH64_RS10075	COG3384	dioxygenase
CH64_RS10090	COG0531	amino acid
CH64_RS10095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CH64_RS10095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CH64_RS10100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CH64_RS10105	COG3025	triphosphatase activity
CH64_RS10110	COG4991	sh3 domain protein
CH64_RS10115	COG0617	tRNA 3'-terminal CCA addition
CH64_RS10120	COG1968	undecaprenyl-diphosphatase activity
CH64_RS10125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CH64_RS10130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CH64_RS10135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CH64_RS10140	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CH64_RS10145	COG0358	DNA primase activity
CH64_RS10175	COG2003	Belongs to the UPF0758 family
CH64_RS10200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH64_RS10230	COG2378	regulation of single-species biofilm formation
CH64_RS10240	COG3596	GTP binding
CH64_RS10280	COG1479	Protein of unknown function DUF262
CH64_RS10300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CH64_RS10315	COG4735	regulation of single-species biofilm formation
CH64_RS10330	COG4983	Phage plasmid primase, P4 family domain protein
CH64_RS10395	COG0297	glycogen (starch) synthase activity
CH64_RS10395	COG0438	transferase activity, transferring glycosyl groups
CH64_RS10400	COG0297	glycogen (starch) synthase activity
CH64_RS10435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CH64_RS10445	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CH64_RS10450	COG1263	PTS System
CH64_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS10460	COG0531	amino acid
CH64_RS10465	COG0076	glutamate decarboxylase activity
CH64_RS10470	COG3247	response to pH
CH64_RS10475	COG1902	pentaerythritol trinitrate reductase activity
CH64_RS10475	COG0446	pyridine nucleotide-disulphide oxidoreductase
CH64_RS10480	COG2813	Specifically methylates the guanine in position
CH64_RS10490	COG1451	nucleotide metabolic process
CH64_RS10495	COG0673	inositol 2-dehydrogenase activity
CH64_RS10500	COG0861	Integral membrane protein TerC family
CH64_RS10505	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CH64_RS10515	COG2721	sulfolactate sulfo-lyase activity
CH64_RS10520	COG0246	Mannitol dehydrogenase
CH64_RS10525	COG1904	glucuronate isomerase
CH64_RS10530	COG2271	Major facilitator Superfamily
CH64_RS10545	COG0586	Pfam SNARE associated Golgi protein
CH64_RS10560	COG4575	ribosome binding
CH64_RS10565	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CH64_RS10575	COG2259	Doxx family
CH64_RS10580	COG0435	Glutathione S-transferase
CH64_RS10585	COG0583	DNA-binding transcription factor activity
CH64_RS10590	COG1741	Belongs to the pirin family
CH64_RS10595	COG1064	alcohol dehydrogenase
CH64_RS10605	COG1566	PFAM secretion protein HlyD family protein
CH64_RS10625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CH64_RS10635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CH64_RS10640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH64_RS10655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CH64_RS10665	COG0792	nuclease activity
CH64_RS10670	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CH64_RS10675	COG2823	Periplasmic or secreted lipoprotein
CH64_RS10680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH64_RS10685	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CH64_RS10690	COG2198	Histidine kinase
CH64_RS10690	COG0784	Response regulator, receiver
CH64_RS10690	COG5002	protein histidine kinase activity
CH64_RS10695	COG1242	4 iron, 4 sulfur cluster binding
CH64_RS10700	COG0067	glutamate synthase
CH64_RS10700	COG0070	glutamate synthase
CH64_RS10700	COG0069	glutamate synthase activity
CH64_RS10705	COG0493	'glutamate synthase
CH64_RS10715	COG2969	positive regulation of protein catabolic process
CH64_RS10720	COG0625	glutathione transferase activity
CH64_RS10725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CH64_RS10730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CH64_RS10735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CH64_RS10740	COG3105	Protein conserved in bacteria
CH64_RS10745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH64_RS10750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH64_RS10755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CH64_RS10760	COG5007	Belongs to the BolA IbaG family
CH64_RS10765	COG3113	response to antibiotic
CH64_RS10770	COG2854	intermembrane phospholipid transfer
CH64_RS10775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CH64_RS10780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CH64_RS10785	COG1127	ABC transporter
CH64_RS10790	COG0530	calcium, potassium:sodium antiporter activity
CH64_RS10795	COG0517	IMP dehydrogenase activity
CH64_RS10795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CH64_RS10800	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CH64_RS10805	COG3117	lipopolysaccharide transmembrane transporter activity
CH64_RS10810	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CH64_RS10815	COG1137	ATPase activity
CH64_RS10820	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CH64_RS10830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS10835	COG1660	Displays ATPase and GTPase activities
CH64_RS10840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS10845	COG0540	Belongs to the ATCase OTCase family
CH64_RS10850	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CH64_RS10860	COG0366	Alpha amylase catalytic
CH64_RS10865	COG1263	PTS System
CH64_RS10865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS10880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS10880	COG3711	transcriptional antiterminator
CH64_RS10895	COG3964	amidohydrolase
CH64_RS10925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH64_RS10930	COG3783	Cytochrome b(562)
CH64_RS10935	COG0312	modulator of DNA gyrase
CH64_RS10945	COG2732	(Barnase) inhibitor
CH64_RS10960	COG1289	transmembrane transporter activity
CH64_RS10965	COG1566	PFAM secretion protein HlyD family protein
CH64_RS10975	COG0583	DNA-binding transcription factor activity
CH64_RS10980	COG0312	modulator of DNA gyrase
CH64_RS10985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CH64_RS10990	COG3164	Protein of unknown function
CH64_RS10995	COG1530	ribonuclease E activity
CH64_RS11000	COG0424	maF-like protein
CH64_RS11005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CH64_RS11010	COG1792	Involved in formation and maintenance of cell shape
CH64_RS11015	COG1077	Cell shape determining protein MreB Mrl
CH64_RS11020	COG2199	diguanylate cyclase activity
CH64_RS11020	COG2200	EAL domain
CH64_RS11025	COG0604	alcohol dehydrogenase
CH64_RS11035	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CH64_RS11040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CH64_RS11045	COG0511	ligase activity, forming carbon-carbon bonds
CH64_RS11050	COG0439	Biotin carboxylase
CH64_RS11055	COG3924	membrane
CH64_RS11060	COG4145	pantothenate transmembrane transporter activity
CH64_RS11065	COG2264	protein methyltransferase activity
CH64_RS11070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH64_RS11075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CH64_RS11085	COG3133	Outer membrane lipoprotein
CH64_RS11090	COG1278	Cold shock
CH64_RS11095	COG1278	Cold shock
CH64_RS11100	COG1278	Cold shock
CH64_RS11105	COG1560	Kdo2-lipid A biosynthetic process
CH64_RS11120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS11125	COG4597	amino acid ABC transporter
CH64_RS11130	COG0765	amino acid transport
CH64_RS11135	COG1126	abc transporter atp-binding protein
CH64_RS11145	COG0025	NhaP-type Na H and K H
CH64_RS11150	COG2252	PERMEase
CH64_RS11165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CH64_RS11170	COG2315	Protein conserved in bacteria
CH64_RS11175	COG1448	Aminotransferase
CH64_RS11200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH64_RS11210	COG0735	belongs to the Fur family
CH64_RS11215	COG3237	CsbD-like
CH64_RS11220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CH64_RS11225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CH64_RS11230	COG2937	Belongs to the GPAT DAPAT family
CH64_RS11240	COG3161	chorismate lyase activity
CH64_RS11255	COG4580	involved in the transport of maltose and maltodextrins
CH64_RS11265	COG2182	Extracellular solute-binding protein
CH64_RS11270	COG1175	transmembrane transport
CH64_RS11275	COG3833	ABC-type maltose transport systems, permease component
CH64_RS11280	COG3223	Belongs to the PsiE family
CH64_RS11290	COG0527	aspartate kinase activity
CH64_RS11305	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CH64_RS11315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CH64_RS11320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CH64_RS11360	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CH64_RS11365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CH64_RS11370	COG0009	L-threonylcarbamoyladenylate synthase
CH64_RS11375	COG0551	DNA topoisomerase type I activity
CH64_RS11385	COG0758	DNA mediated transformation
CH64_RS11390	COG0242	peptide deformylase activity
CH64_RS11395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CH64_RS11400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH64_RS11400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CH64_RS11410	COG1970	mechanosensitive ion channel activity
CH64_RS11415	COG3036	rescue of stalled ribosome
CH64_RS11420	COG0789	Transcriptional regulator
CH64_RS11430	COG0203	ribosomal protein L17
CH64_RS11435	COG0202	RNA polymerase activity
CH64_RS11440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CH64_RS11450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CH64_RS11455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH64_RS11460	COG0201	protein transport
CH64_RS11465	COG0200	Binds to the 23S rRNA
CH64_RS11470	COG1841	ribosomal large subunit assembly
CH64_RS11475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CH64_RS11495	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CH64_RS11510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CH64_RS11515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CH64_RS11520	COG0255	Belongs to the universal ribosomal protein uL29 family
CH64_RS11525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CH64_RS11530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CH64_RS11535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CH64_RS11540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CH64_RS11545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CH64_RS11550	COG0089	rRNA binding
CH64_RS11560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CH64_RS11565	COG0051	transcription antitermination factor activity, RNA binding
CH64_RS11590	COG0049	tRNA binding
CH64_RS11595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CH64_RS11600	COG2168	tRNA wobble position uridine thiolation
CH64_RS11605	COG2923	Belongs to the DsrF TusC family
CH64_RS11610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH64_RS11615	COG2964	Protein conserved in bacteria
CH64_RS11620	COG0545	Peptidyl-prolyl cis-trans isomerase
CH64_RS11630	COG1047	Peptidyl-prolyl cis-trans
CH64_RS11635	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CH64_RS11645	COG2249	NAD(P)H dehydrogenase (quinone) activity
CH64_RS11650	COG0488	(ABC) transporter
CH64_RS11655	COG1216	Glycosyl transferase, family 2
CH64_RS11675	COG0429	hydrolase of the alpha beta-hydrolase fold
CH64_RS11680	COG3089	Belongs to the UPF0270 family
CH64_RS11685	COG3954	Phosphoribulokinase
CH64_RS11690	COG1765	OsmC-like protein
CH64_RS11700	COG1289	transmembrane transporter activity
CH64_RS11715	COG0433	COG0433 Predicted ATPase
CH64_RS11720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH64_RS11725	COG1486	melibiose metabolic process
CH64_RS11730	COG1609	Transcriptional regulator
CH64_RS11735	COG0738	Major facilitator superfamily
CH64_RS11740	COG0402	S-adenosylhomocysteine deaminase activity
CH64_RS11745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH64_RS11760	COG1648	precorrin-2 dehydrogenase activity
CH64_RS11760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH64_RS11765	COG0180	Tryptophanyl-tRNA synthetase
CH64_RS11770	COG0546	phosphoglycolate phosphatase activity
CH64_RS11775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CH64_RS11795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH64_RS11800	COG4796	Type ii and iii secretion system protein
CH64_RS11825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CH64_RS11830	COG0494	nUDIX hydrolase
CH64_RS11840	COG1011	Hydrolase
CH64_RS11845	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CH64_RS11855	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CH64_RS11870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CH64_RS11875	COG2183	response to ionizing radiation
CH64_RS11880	COG1918	ferrous iron import across plasma membrane
CH64_RS11895	COG0596	Alpha beta hydrolase
CH64_RS11905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CH64_RS11905	COG0316	Belongs to the HesB IscA family
CH64_RS11910	COG1640	4-alpha-glucanotransferase
CH64_RS11915	COG0058	SHG alpha-glucan phosphorylase activity
CH64_RS11920	COG2909	trisaccharide binding
CH64_RS11935	COG0705	Rhomboid family
CH64_RS11940	COG1349	DNA-binding transcription factor activity
CH64_RS11945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH64_RS11950	COG0058	SHG alpha-glucan phosphorylase activity
CH64_RS11955	COG0297	glycogen (starch) synthase activity
CH64_RS11960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CH64_RS11965	COG1523	belongs to the glycosyl hydrolase 13 family
CH64_RS11970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CH64_RS11975	COG3275	phosphorelay sensor kinase activity
CH64_RS11995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CH64_RS12000	COG2095	MarC family integral membrane protein
CH64_RS12005	COG3265	gluconokinase activity
CH64_RS12010	COG2610	gluconate transmembrane transporter activity
CH64_RS12015	COG1609	Transcriptional regulator
CH64_RS12020	COG1741	Belongs to the pirin family
CH64_RS12025	COG1247	-acetyltransferase
CH64_RS12030	COG1082	Xylose isomerase domain protein TIM barrel
CH64_RS12035	COG0673	inositol 2-dehydrogenase activity
CH64_RS12055	COG3718	enzyme involved in inositol metabolism
CH64_RS12070	COG2814	Major facilitator Superfamily
CH64_RS12075	COG0583	DNA-binding transcription factor activity
CH64_RS12095	COG2081	HI0933 family
CH64_RS12100	COG0306	phosphate transporter
CH64_RS12110	COG0589	response to stress
CH64_RS12125	COG0742	ribosomal rna small subunit methyltransferase
CH64_RS12140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CH64_RS12145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH64_RS12150	COG1295	ribonuclease BN
CH64_RS12155	COG2134	cdp-diacylglycerol pyrophosphatase
CH64_RS12160	COG2982	Protein involved in outer membrane biogenesis
CH64_RS12165	COG2200	EAL domain
CH64_RS12170	COG1942	4-Oxalocrotonate Tautomerase
CH64_RS12175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_RS12180	COG0612	Peptidase, M16
CH64_RS12185	COG1301	dicarboxylic acid transport
CH64_RS12195	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH64_RS12200	COG2200	EAL domain
CH64_RS12200	COG2199	diguanylate cyclase activity
CH64_RS12205	COG4608	Belongs to the ABC transporter superfamily
CH64_RS12210	COG0444	Belongs to the ABC transporter superfamily
CH64_RS12215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_RS12220	COG0601	transmembrane transport
CH64_RS12225	COG0747	negative chemotaxis
CH64_RS12230	COG3210	domain, Protein
CH64_RS12235	COG2831	hemolysin activation secretion protein
CH64_RS12240	COG3210	domain, Protein
CH64_RS12250	COG2271	Major facilitator Superfamily
CH64_RS12255	COG3851	Histidine kinase
CH64_RS12260	COG2197	response regulator
CH64_RS12265	COG2194	sulfuric ester hydrolase activity
CH64_RS12270	COG1764	response to oxidative stress
CH64_RS12275	COG1846	Transcriptional regulator
CH64_RS12290	COG2986	histidine ammonia-lyase
CH64_RS12295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CH64_RS12300	COG2979	Protein of unknown function (DUF533)
CH64_RS12310	COG2207	Transcriptional regulator
CH64_RS12310	COG1609	Transcriptional regulator
CH64_RS12315	COG4214	carbohydrate transport
CH64_RS12325	COG4213	ABC transporter substrate-binding protein
CH64_RS12330	COG2115	Belongs to the xylose isomerase family
CH64_RS12335	COG1070	Carbohydrate kinase
CH64_RS12340	COG1335	isochorismatase
CH64_RS12350	COG3274	enterobacterial common antigen metabolic process
CH64_RS12365	COG3276	selenocysteine insertion sequence binding
CH64_RS12370	COG1921	L-seryl-tRNASec selenium transferase activity
CH64_RS12380	COG3058	Necessary for formate dehydrogenase activity
CH64_RS12385	COG2864	formate dehydrogenase
CH64_RS12390	COG0437	4 iron, 4 sulfur cluster binding
CH64_RS12395	COG0243	molybdopterin cofactor binding
CH64_RS12395	COG3383	formate dehydrogenase (NAD+) activity
CH64_RS12400	COG0243	molybdopterin cofactor binding
CH64_RS12400	COG3383	formate dehydrogenase (NAD+) activity
CH64_RS12405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CH64_RS12410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CH64_RS12415	COG0840	transmembrane signaling receptor activity
CH64_RS12420	COG2258	MOSC domain
CH64_RS12430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_RS12440	COG3722	fumarate hydratase activity
CH64_RS12445	COG0246	Mannitol dehydrogenase
CH64_RS12450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS12450	COG2213	PTS system mannitol-specific
CH64_RS12460	COG0751	glycine-tRNA ligase activity
CH64_RS12465	COG0752	glycyl-tRNA synthetase alpha subunit
CH64_RS12470	COG2818	Glycosylase
CH64_RS12495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CH64_RS12500	COG0366	Alpha amylase catalytic
CH64_RS12505	COG3977	Valine--pyruvate aminotransferase
CH64_RS12510	COG2985	domain, Protein
CH64_RS12510	COG0569	domain protein
CH64_RS12530	COG5645	(Lipo)protein
CH64_RS12535	COG0823	Involved in the tonB-independent uptake of proteins
CH64_RS12545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH64_RS12550	COG2423	ornithine cyclodeaminase activity
CH64_RS12555	COG0561	phosphatase activity
CH64_RS12560	COG0187	DNA topoisomerase II activity
CH64_RS12565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CH64_RS12570	COG0592	DNA-directed DNA polymerase activity
CH64_RS12580	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CH64_RS12585	COG0594	ribonuclease P activity
CH64_RS12590	COG0706	membrane insertase activity
CH64_RS12595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CH64_RS12600	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CH64_RS12615	COG2011	ABC-type metal ion transport system permease component
CH64_RS12620	COG0840	transmembrane signaling receptor activity
CH64_RS12625	COG0431	NADPH-dependent FMN reductase
CH64_RS12645	COG2252	PERMEase
CH64_RS12650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_RS12655	COG0765	amino acid transport
CH64_RS12660	COG0765	amino acid transport
CH64_RS12665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS12675	COG3876	Protein conserved in bacteria
CH64_RS12685	COG1472	Belongs to the glycosyl hydrolase 3 family
CH64_RS12690	COG0704	Plays a role in the regulation of phosphate uptake
CH64_RS12700	COG0581	inorganic phosphate transmembrane transporter activity
CH64_RS12705	COG0573	inorganic phosphate transmembrane transporter activity
CH64_RS12710	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CH64_RS12725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CH64_RS12730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CH64_RS12735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CH64_RS12745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CH64_RS12755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CH64_RS12765	COG0356	it plays a direct role in the translocation of protons across the membrane
CH64_RS12770	COG3312	ion transport
CH64_RS12775	COG0357	Ribosomal RNA small subunit methyltransferase G
CH64_RS12780	COG0445	tRNA wobble uridine modification
CH64_RS12785	COG0716	FMN binding
CH64_RS12790	COG1522	sequence-specific DNA binding
CH64_RS12805	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CH64_RS12810	COG0714	Associated with various cellular activities
CH64_RS12815	COG3158	transport of potassium into the cell
CH64_RS12820	COG1869	D-ribose catabolic process
CH64_RS12830	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS12835	COG1879	ABC-type sugar transport system periplasmic component
CH64_RS12840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_RS12845	COG1609	Transcriptional regulator
CH64_RS12850	COG0477	Major facilitator Superfamily
CH64_RS12855	COG2186	Transcriptional regulator
CH64_RS12885	COG1763	Mo-molybdopterin cofactor biosynthetic process
CH64_RS12895	COG3084	Protein conserved in bacteria
CH64_RS12900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CH64_RS12905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CH64_RS12910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH64_RS12910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CH64_RS12925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CH64_RS12935	COG3852	Histidine kinase
CH64_RS12950	COG1011	Hydrolase
CH64_RS12955	COG1295	ribonuclease BN
CH64_RS12960	COG1490	D-aminoacyl-tRNA deacylase activity
CH64_RS12965	COG0456	acetyltransferase
CH64_RS12970	COG3423	Transcriptional regulator
CH64_RS12975	COG2197	response regulator
CH64_RS12985	COG2982	Protein involved in outer membrane biogenesis
CH64_RS12990	COG2233	PERMEase
CH64_RS12995	COG0786	glutamate:sodium symporter activity
CH64_RS13000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CH64_RS13005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH64_RS13010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH64_RS13015	COG1758	RNA polymerase activity
CH64_RS13025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CH64_RS13030	COG2860	membrane
CH64_RS13035	COG1024	Enoyl-CoA hydratase
CH64_RS13040	COG5001	Diguanylate cyclase
CH64_RS13045	COG1561	YicC-like family, N-terminal region
CH64_RS13055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CH64_RS13060	COG1309	transcriptional regulator
CH64_RS13065	COG0756	dUTP diphosphatase activity
CH64_RS13070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CH64_RS13075	COG2003	Belongs to the UPF0758 family
CH64_RS13080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CH64_RS13085	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CH64_RS13090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CH64_RS13095	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CH64_RS13105	COG1519	Transferase
CH64_RS13110	COG0859	PFAM glycosyl transferase family 9
CH64_RS13115	COG0859	PFAM glycosyl transferase family 9
CH64_RS13120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CH64_RS13125	COG0156	8-amino-7-oxononanoate synthase activity
CH64_RS13135	COG2861	carbohydrate metabolic process
CH64_RS13140	COG4942	peptidase
CH64_RS13145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CH64_RS13150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH64_RS13155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH64_RS13160	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CH64_RS13165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CH64_RS13170	COG1045	serine acetyltransferase
CH64_RS13175	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CH64_RS13180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CH64_RS13180	COG2169	Transcriptional regulator
CH64_RS13185	COG2205	protein histidine kinase activity
CH64_RS13190	COG0745	RESPONSE REGULATOR receiver
CH64_RS13195	COG3678	ATP-independent chaperone mediated protein folding
CH64_RS13200	COG4974	Belongs to the 'phage' integrase family
CH64_RS13210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CH64_RS13220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CH64_RS13240	COG3152	Membrane
CH64_RS13250	COG2814	Major facilitator Superfamily
CH64_RS13255	COG1494	fructose-1,6-bisphosphatase
CH64_RS13265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH64_RS13270	COG3074	FtsZ-dependent cytokinesis
CH64_RS13275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CH64_RS13280	COG1575	Belongs to the MenA family. Type 1 subfamily
CH64_RS13285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CH64_RS13290	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CH64_RS13295	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH64_RS13300	COG1609	Transcriptional regulator
CH64_RS13305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CH64_RS13310	COG0254	rRNA binding
CH64_RS13320	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
CH64_RS13325	COG0626	cystathionine gamma-synthase activity
CH64_RS13330	COG0460	homoserine dehydrogenase
CH64_RS13330	COG0527	aspartate kinase activity
CH64_RS13340	COG0477	Major facilitator Superfamily
CH64_RS13345	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CH64_RS13355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CH64_RS13365	COG0165	Argininosuccinate lyase
CH64_RS13370	COG1629	transport
CH64_RS13400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH64_RS13405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CH64_RS13405	COG0678	peroxiredoxin activity
CH64_RS13420	COG1309	transcriptional regulator
CH64_RS13430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH64_RS13440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CH64_RS13480	COG1879	ABC-type sugar transport system periplasmic component
CH64_RS13485	COG1129	ABC transporter
CH64_RS13490	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS13495	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS13500	COG0583	DNA-binding transcription factor activity
CH64_RS13505	COG3085	chromosome segregation
CH64_RS13520	COG3978	acetolactate synthase activity
CH64_RS13525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CH64_RS13530	COG0129	dihydroxy-acid dehydratase activity
CH64_RS13535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CH64_RS13540	COG0583	DNA-binding transcription factor activity
CH64_RS13545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CH64_RS13550	COG3121	Chaperone
CH64_RS13565	COG3121	Chaperone
CH64_RS13575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH64_RS13590	COG0248	Ppx GppA phosphatase
CH64_RS13600	COG3118	belongs to the thioredoxin family
CH64_RS13605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CH64_RS13610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH64_RS13615	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CH64_RS13620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CH64_RS13625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CH64_RS13630	COG1088	dTDP-glucose 4,6-dehydratase activity
CH64_RS13635	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CH64_RS13640	COG0456	acetyltransferase
CH64_RS13645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CH64_RS13650	COG2244	polysaccharide biosynthetic process
CH64_RS13655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH64_RS13695	COG3071	HemY protein
CH64_RS13700	COG2959	enzyme of heme biosynthesis
CH64_RS13705	COG1587	Uroporphyrinogen-III synthase
CH64_RS13710	COG0181	hydroxymethylbilane synthase activity
CH64_RS13715	COG3072	Adenylate cyclase
CH64_RS13735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CH64_RS13740	COG3159	Protein conserved in bacteria
CH64_RS13745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CH64_RS13750	COG1011	Hydrolase
CH64_RS13755	COG0210	DNA helicase
CH64_RS13765	COG5441	Belongs to the UPF0261 family
CH64_RS13770	COG5564	TIM-barrel signal transduction protein
CH64_RS13790	COG2050	protein possibly involved in aromatic compounds catabolism
CH64_RS13800	COG0514	ATP-dependent DNA helicase (RecQ)
CH64_RS13805	COG1280	lysine exporter protein (LysE YggA)
CH64_RS13810	COG1280	lysine exporter protein (LysE YggA)
CH64_RS13815	COG2267	carboxylic ester hydrolase activity
CH64_RS13820	COG0561	phosphatase activity
CH64_RS13825	COG0584	glycerophosphoryl diester phosphodiesterase
CH64_RS13830	COG2271	Major facilitator Superfamily
CH64_RS13835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CH64_RS13840	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CH64_RS13845	COG0247	lactate metabolic process
CH64_RS13855	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CH64_RS13860	COG0425	Belongs to the sulfur carrier protein TusA family
CH64_RS13870	COG3714	YhhN family
CH64_RS13885	COG3776	membrane
CH64_RS13890	COG0742	ribosomal rna small subunit methyltransferase
CH64_RS13895	COG0552	protein localization to endoplasmic reticulum
CH64_RS13895	COG0552	protein localization to endoplasmic reticulum
CH64_RS13900	COG2884	Cell division ATP-binding protein ftsE
CH64_RS13905	COG2177	Part of the ABC transporter FtsEX involved in
CH64_RS13915	COG0456	acetyltransferase
CH64_RS13920	COG0683	leucine binding
CH64_RS13930	COG4177	L-phenylalanine transmembrane transporter activity
CH64_RS13940	COG0410	ABC transporter
CH64_RS13975	COG1653	transport
CH64_RS13980	COG1175	transmembrane transport
CH64_RS13985	COG0395	ABC-type sugar transport system, permease component
CH64_RS13990	COG3842	ATPase activity
CH64_RS13995	COG0584	glycerophosphoryl diester phosphodiesterase
CH64_RS14000	COG0679	Auxin Efflux Carrier
CH64_RS14005	COG0697	spore germination
CH64_RS14010	COG0583	DNA-binding transcription factor activity
CH64_RS14015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CH64_RS14020	COG0412	Dienelactone hydrolase
CH64_RS14035	COG1966	Carbon starvation protein
CH64_RS14040	COG0586	Pfam SNARE associated Golgi protein
CH64_RS14045	COG1322	Protein conserved in bacteria
CH64_RS14050	COG2226	methyltransferase
CH64_RS14060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CH64_RS14065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH64_RS14070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CH64_RS14075	COG0805	protein transport
CH64_RS14095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CH64_RS14105	COG0183	Belongs to the thiolase family
CH64_RS14110	COG1250	3-hydroxyacyl-CoA dehydrogenase
CH64_RS14110	COG1024	Enoyl-CoA hydratase
CH64_RS14120	COG1739	Uncharacterized protein family UPF0029
CH64_RS14125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CH64_RS14165	COG1072	(Pantothenic acid kinase))
CH64_RS14205	COG0250	Participates in transcription elongation, termination and antitermination
CH64_RS14210	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CH64_RS14220	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CH64_RS14225	COG0222	ribosome binding
CH64_RS14230	COG0085	RNA polymerase activity
CH64_RS14235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CH64_RS14245	COG2022	thiamine diphosphate biosynthetic process
CH64_RS14250	COG2104	thiamine diphosphate biosynthetic process
CH64_RS14255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH64_RS14275	COG2816	NAD+ diphosphatase activity
CH64_RS14280	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CH64_RS14285	COG1515	deoxyribonuclease V activity
CH64_RS14305	COG0151	Belongs to the GarS family
CH64_RS14310	COG0138	bifunctional purine biosynthesis protein purh
CH64_RS14345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CH64_RS14350	COG3162	membrane
CH64_RS14355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CH64_RS14360	COG1301	dicarboxylic acid transport
CH64_RS14365	COG2197	response regulator
CH64_RS14370	COG5002	protein histidine kinase activity
CH64_RS14370	COG0784	Response regulator, receiver
CH64_RS14370	COG2205	protein histidine kinase activity
CH64_RS14525	COG2391	methyltransferase activity
CH64_RS14530	COG0425	Belongs to the sulfur carrier protein TusA family
CH64_RS14535	COG3264	Mechanosensitive ion channel
CH64_RS14535	COG1196	nuclear chromosome segregation
CH64_RS14545	COG4774	siderophore transport
CH64_RS14555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CH64_RS14560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CH64_RS14565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_RS14570	COG4558	Periplasmic binding protein
CH64_RS14575	COG3720	iron ion transport
CH64_RS14595	COG3721	Heme iron utilization protein
CH64_RS14610	COG0114	fumarate hydratase activity
CH64_RS14615	COG0281	malic enzyme
CH64_RS14640	COG0463	Glycosyl transferase, family 2
CH64_RS14655	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CH64_RS14690	COG1309	transcriptional regulator
CH64_RS14695	COG1929	Belongs to the glycerate kinase type-1 family
CH64_RS14700	COG4232	protein-disulfide reductase activity
CH64_RS14710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH64_RS14725	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CH64_RS14730	COG0459	protein refolding
CH64_RS14740	COG1509	lysine 2,3-aminomutase activity
CH64_RS14745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CH64_RS14765	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH64_RS14770	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CH64_RS14775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CH64_RS14780	COG1053	succinate dehydrogenase
CH64_RS14790	COG1511	domain protein
CH64_RS14790	COG3264	Mechanosensitive ion channel
CH64_RS14795	COG0688	phosphatidylethanolamine metabolic process
CH64_RS14800	COG1162	GTPase activity
CH64_RS14805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CH64_RS14825	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CH64_RS14830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CH64_RS14830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CH64_RS14835	COG0802	atpase or kinase
CH64_RS14840	COG0860	N-Acetylmuramoyl-L-alanine amidase
CH64_RS14845	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CH64_RS14850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CH64_RS14855	COG1923	regulation of RNA biosynthetic process
CH64_RS14860	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CH64_RS14865	COG0330	HflC and HflK could
CH64_RS14870	COG0330	HflC and HflK could
CH64_RS14875	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CH64_RS14880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CH64_RS14885	COG1959	2 iron, 2 sulfur cluster binding
CH64_RS14890	COG0557	exoribonuclease II activity
CH64_RS14895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH64_RS14900	COG1960	acyl-CoA dehydrogenase activity
CH64_RS14905	COG3650	response to hydrogen peroxide
CH64_RS14910	COG1073	alpha beta
CH64_RS14920	COG0360	Binds together with S18 to 16S ribosomal RNA
CH64_RS14925	COG2965	DNA replication, synthesis of RNA primer
CH64_RS14930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CH64_RS14935	COG0359	binds to the 23S rRNA
CH64_RS14945	COG3061	Opacity-associated protein A
CH64_RS14950	COG0545	Peptidyl-prolyl cis-trans isomerase
CH64_RS14960	COG0737	Belongs to the 5'-nucleotidase family
CH64_RS14965	COG1218	3'(2'),5'-bisphosphate nucleotidase
CH64_RS14970	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CH64_RS14980	COG1253	flavin adenine dinucleotide binding
CH64_RS14985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CH64_RS14990	COG0729	surface antigen
CH64_RS15000	COG2105	PFAM AIG2 family protein
CH64_RS15005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CH64_RS15010	COG0840	transmembrane signaling receptor activity
CH64_RS15020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH64_RS15040	COG0039	L-malate dehydrogenase activity
CH64_RS15045	COG3423	Transcriptional regulator
CH64_RS15055	COG0142	geranyltranstransferase activity
CH64_RS15070	COG0697	spore germination
CH64_RS15075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CH64_RS15080	COG0642	Histidine kinase
CH64_RS15085	COG0745	RESPONSE REGULATOR receiver
CH64_RS15090	COG2027	D-alanyl-D-alanine carboxypeptidase
CH64_RS15100	COG1534	Rna-binding protein
CH64_RS15105	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CH64_RS15115	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CH64_RS15125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CH64_RS15140	COG0779	Required for maturation of 30S ribosomal subunits
CH64_RS15145	COG0195	Participates in both transcription termination and antitermination
CH64_RS15150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CH64_RS15155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CH64_RS15160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CH64_RS15170	COG1185	polyribonucleotide nucleotidyltransferase activity
CH64_RS15180	COG0513	Belongs to the DEAD box helicase family
CH64_RS15190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CH64_RS15195	COG0826	peptidase U32
CH64_RS15200	COG0826	peptidase U32
CH64_RS15205	COG3154	lipid carrier protein
CH64_RS15210	COG3153	acetyltransferase
CH64_RS15215	COG2827	Endonuclease containing a URI domain
CH64_RS15220	COG0531	amino acid
CH64_RS15225	COG1982	Orn Lys Arg decarboxylase major
CH64_RS15240	COG1653	transport
CH64_RS15245	COG1175	transmembrane transport
CH64_RS15250	COG0395	ABC-type sugar transport system, permease component
CH64_RS15255	COG3842	ATPase activity
CH64_RS15265	COG3787	Belongs to the UPF0306 family
CH64_RS15270	COG0702	epimerase
CH64_RS15275	COG0602	queuosine metabolic process
CH64_RS15285	COG4608	Belongs to the ABC transporter superfamily
CH64_RS15290	COG0444	Belongs to the ABC transporter superfamily
CH64_RS15295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CH64_RS15300	COG0601	transmembrane transport
CH64_RS15310	COG2731	YhcH YjgK YiaL family protein
CH64_RS15320	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CH64_RS15340	COG2927	DNA polymerase III (CHI subunit)
CH64_RS15345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CH64_RS15350	COG0795	lipopolysaccharide-transporting ATPase activity
CH64_RS15355	COG0795	lipopolysaccharide-transporting ATPase activity
CH64_RS15370	COG1518	maintenance of DNA repeat elements
CH64_RS15375	COG1203	CRISPR-associated helicase, Cas3
CH64_RS15465	COG3121	Chaperone
CH64_RS15470	COG3188	usher protein
CH64_RS15560	COG2197	response regulator
CH64_RS15565	COG0784	Response regulator, receiver
CH64_RS15565	COG2198	Histidine kinase
CH64_RS15565	COG2205	protein histidine kinase activity
CH64_RS15565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS15570	COG4932	domain protein
CH64_RS15570	COG2373	Large extracellular alpha-helical protein
CH64_RS15570	COG1388	LysM domain
CH64_RS15575	COG2850	peptidyl-arginine hydroxylation
CH64_RS15605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CH64_RS15610	COG1830	Aldolase
CH64_RS15615	COG1879	ABC-type sugar transport system periplasmic component
CH64_RS15620	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS15625	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS15630	COG1129	ABC transporter
CH64_RS15635	COG2390	Transcriptional regulator
CH64_RS15640	COG1070	Carbohydrate kinase
CH64_RS15645	COG0859	PFAM glycosyl transferase family 9
CH64_RS15660	COG2235	arginine
CH64_RS15665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS15670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_RS15680	COG2376	Dihydroxyacetone kinase
CH64_RS15685	COG1461	Dihydroxyacetone kinase
CH64_RS15690	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CH64_RS15690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CH64_RS15690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CH64_RS15695	COG3284	Transcriptional regulator
CH64_RS15750	COG0583	DNA-binding transcription factor activity
CH64_RS15755	COG0667	Aldo Keto reductase
CH64_RS15760	COG2813	Specifically methylates the guanine in position
CH64_RS15765	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CH64_RS15775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CH64_RS15780	COG2823	Periplasmic or secreted lipoprotein
CH64_RS15785	COG4667	esterase of the alpha-beta hydrolase superfamily
CH64_RS15790	COG0084	hydrolase, TatD family'
CH64_RS15795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CH64_RS15805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CH64_RS15810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CH64_RS15820	COG3726	membrane protein affecting hemolysin expression
CH64_RS15825	COG0560	Phosphoserine phosphatase
CH64_RS15840	COG0604	alcohol dehydrogenase
CH64_RS15850	COG0488	(ABC) transporter
CH64_RS15855	COG0582	viral genome integration into host DNA
CH64_RS15865	COG2885	chlorophyll binding
CH64_RS15870	COG2199	diguanylate cyclase activity
CH64_RS15880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CH64_RS15885	COG0741	lytic transglycosylase activity
CH64_RS15890	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CH64_RS15895	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CH64_RS15900	COG0406	alpha-ribazole phosphatase activity
CH64_RS15905	COG2207	Transcriptional regulator
CH64_RS15905	COG3708	Transcriptional regulator
CH64_RS15910	COG3045	CreA protein
CH64_RS15915	COG0745	RESPONSE REGULATOR receiver
CH64_RS15940	COG3022	response to hydroperoxide
CH64_RS15945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CH64_RS15950	COG0521	Mo-molybdopterin cofactor biosynthetic process
CH64_RS15965	COG1584	GPR1 FUN34 yaaH family protein
CH64_RS15975	COG0484	heat shock protein binding
CH64_RS15980	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CH64_RS15985	COG0583	DNA-binding transcription factor activity
CH64_RS16000	COG0196	riboflavin kinase activity
CH64_RS16005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CH64_RS16010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CH64_RS16015	COG1047	Peptidyl-prolyl cis-trans
CH64_RS16020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CH64_RS16025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CH64_RS16035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CH64_RS16040	COG1280	lysine exporter protein (LysE YggA)
CH64_RS16045	COG2966	Psort location CytoplasmicMembrane, score
CH64_RS16055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CH64_RS16060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH64_RS16065	COG2967	ApaG domain
CH64_RS16085	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CH64_RS16100	COG0564	pseudouridine synthase activity
CH64_RS16110	COG0417	DNA replication proofreading
CH64_RS16115	COG0586	Pfam SNARE associated Golgi protein
CH64_RS16125	COG1178	ABC-type Fe3 transport system permease component
CH64_RS16130	COG4143	(ABC) transporter
CH64_RS16135	COG4533	DNA binding
CH64_RS16140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CH64_RS16145	COG1882	Formate acetyltransferase
CH64_RS16155	COG2814	Major facilitator Superfamily
CH64_RS16160	COG3033	Beta-eliminating lyase
CH64_RS16170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CH64_RS16175	COG0473	3-isopropylmalate dehydrogenase activity
CH64_RS16180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CH64_RS16190	COG1022	Amp-dependent synthetase and ligase
CH64_RS16195	COG0028	Belongs to the TPP enzyme family
CH64_RS16220	COG0275	rRNA processing
CH64_RS16225	COG3116	cell division
CH64_RS16230	COG0768	penicillin binding
CH64_RS16235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CH64_RS16240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CH64_RS16245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH64_RS16255	COG0772	Belongs to the SEDS family
CH64_RS16260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CH64_RS16265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CH64_RS16275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CH64_RS16280	COG0849	cell division
CH64_RS16285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CH64_RS16305	COG0653	protein targeting
CH64_RS16310	COG0494	nUDIX hydrolase
CH64_RS16315	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CH64_RS16330	COG0516	GMP reductase activity
CH64_RS16345	COG1459	type II secretion system
CH64_RS16350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CH64_RS16355	COG4969	Belongs to the N-Me-Phe pilin family
CH64_RS16365	COG3023	N-Acetylmuramoyl-L-alanine amidase
CH64_RS16370	COG3725	Membrane protein required for beta-lactamase induction
CH64_RS16375	COG1113	amino acid transport
CH64_RS16380	COG2186	Transcriptional regulator
CH64_RS16385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CH64_RS16390	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH64_RS16395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CH64_RS16405	COG2207	Transcriptional regulator
CH64_RS16420	COG3112	Uncharacterised protein family (UPF0231)
CH64_RS16425	COG0697	spore germination
CH64_RS16475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CH64_RS16485	COG2132	Multicopper oxidase
CH64_RS16490	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CH64_RS16495	COG0288	reversible hydration of carbon dioxide
CH64_RS16500	COG1131	(ABC) transporter
CH64_RS16505	COG0842	Transport permease protein
CH64_RS16510	COG0726	polysaccharide deacetylase
CH64_RS16515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CH64_RS16525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CH64_RS16530	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CH64_RS16535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CH64_RS16540	COG0617	tRNA 3'-terminal CCA addition
CH64_RS16545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH64_RS16550	COG1643	Atp-dependent helicase
CH64_RS16555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CH64_RS16560	COG1120	ATPase activity
CH64_RS16565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CH64_RS16570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CH64_RS16580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CH64_RS16590	COG0316	Belongs to the HesB IscA family
CH64_RS16595	COG2860	membrane
CH64_RS16605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CH64_RS16610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CH64_RS16615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CH64_RS16620	COG3437	response regulator, receiver
CH64_RS16620	COG4999	Histidine kinase
CH64_RS16620	COG2205	protein histidine kinase activity
CH64_RS16620	COG3850	Histidine kinase
CH64_RS16625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CH64_RS16630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CH64_RS16635	COG3956	TIGRFAM MazG family protein
CH64_RS16640	COG0504	CTP synthase activity
CH64_RS16665	COG0602	queuosine metabolic process
CH64_RS16670	COG0720	synthase
CH64_RS16675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CH64_RS16680	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CH64_RS16685	COG0175	sulfate reduction
CH64_RS16690	COG2234	aminopeptidase activity
CH64_RS16695	COG1648	precorrin-2 dehydrogenase activity
CH64_RS16695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CH64_RS16700	COG0175	sulfate reduction
CH64_RS16705	COG2895	sulfate adenylyltransferase (ATP) activity
CH64_RS16710	COG0529	Catalyzes the synthesis of activated sulfate
CH64_RS16725	COG0765	amino acid transport
CH64_RS16735	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CH64_RS16750	COG0585	pseudouridine synthase activity
CH64_RS16755	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CH64_RS16760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CH64_RS16765	COG4942	peptidase
CH64_RS16765	COG1388	LysM domain
CH64_RS16770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CH64_RS16775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CH64_RS16790	COG3539	Fimbrial protein
CH64_RS16795	COG3188	usher protein
CH64_RS16800	COG3121	Chaperone
CH64_RS16810	COG3539	Fimbrial protein
CH64_RS16845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS16850	COG1136	(ABC) transporter
CH64_RS16850	COG0577	efflux transmembrane transporter activity
CH64_RS16855	COG1538	Outer membrane efflux protein
CH64_RS16875	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS16890	COG0583	DNA-binding transcription factor activity
CH64_RS16895	COG2610	gluconate transmembrane transporter activity
CH64_RS16900	COG3048	D-serine ammonia-lyase activity
CH64_RS16905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS16910	COG0765	amino acid transport
CH64_RS16915	COG0765	amino acid transport
CH64_RS16920	COG1126	abc transporter atp-binding protein
CH64_RS16925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CH64_RS16930	COG3665	Urea carboxylase-associated protein
CH64_RS16945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CH64_RS16950	COG0640	Transcriptional regulator
CH64_RS16955	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_RS16955	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CH64_RS16960	COG0243	molybdopterin cofactor binding
CH64_RS16965	COG0437	4 iron, 4 sulfur cluster binding
CH64_RS16970	COG3302	dmso reductase anchor subunit
CH64_RS16975	COG3381	protein complex oligomerization
CH64_RS16980	COG1879	ABC-type sugar transport system periplasmic component
CH64_RS16990	COG1129	ABC transporter
CH64_RS16995	COG1172	Belongs to the binding-protein-dependent transport system permease family
CH64_RS17000	COG3959	Transketolase, thiamine diphosphate binding domain
CH64_RS17005	COG3958	Transketolase
CH64_RS17010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CH64_RS17035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CH64_RS17040	COG2137	regulation of response to DNA damage stimulus
CH64_RS17045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CH64_RS17050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CH64_RS17075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CH64_RS17080	COG1238	metal cluster binding
CH64_RS17085	COG2918	glutathione biosynthetic process
CH64_RS17090	COG1854	S-ribosylhomocysteine lyase activity
CH64_RS17095	COG4536	flavin adenine dinucleotide binding
CH64_RS17100	COG4137	Cytochrome C assembly protein
CH64_RS17105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CH64_RS17110	COG0228	four-way junction DNA binding
CH64_RS17115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CH64_RS17120	COG0336	Belongs to the RNA methyltransferase TrmD family
CH64_RS17125	COG0335	large ribosomal subunit rRNA binding
CH64_RS17130	COG3137	Salt-induced outer membrane protein
CH64_RS17135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CH64_RS17140	COG3279	Response regulator of the LytR AlgR family
CH64_RS17145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH64_RS17150	COG1605	Chorismate mutase
CH64_RS17150	COG0287	Prephenate dehydrogenase
CH64_RS17155	COG1605	Chorismate mutase
CH64_RS17155	COG0077	Prephenate dehydratase
CH64_RS17160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CH64_RS17165	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CH64_RS17170	COG0564	pseudouridine synthase activity
CH64_RS17180	COG0542	response to heat
CH64_RS17210	COG5544	Lipoprotein
CH64_RS17215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CH64_RS17220	COG0045	succinate-CoA ligase (ADP-forming) activity
CH64_RS17220	COG1042	CoA-binding domain protein
CH64_RS17220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CH64_RS17225	COG3148	PFAM DTW domain containing protein
CH64_RS17230	COG3118	belongs to the thioredoxin family
CH64_RS17235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CH64_RS17240	COG2814	Major facilitator Superfamily
CH64_RS17245	COG1566	PFAM secretion protein HlyD family protein
CH64_RS17250	COG1846	Transcriptional regulator
CH64_RS17260	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CH64_RS17265	COG2814	Major facilitator Superfamily
CH64_RS17280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CH64_RS17295	COG0436	Aminotransferase
CH64_RS17300	COG0235	Class ii aldolase
CH64_RS17305	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
CH64_RS17310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CH64_RS17320	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CH64_RS17335	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
CH64_RS17340	COG1960	acyl-CoA dehydrogenase activity
CH64_RS17350	COG0121	glutamine amidotransferase
CH64_RS17355	COG3034	peptidoglycan biosynthetic process
CH64_RS17360	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_RS17365	COG1805	sodium ion transport
CH64_RS17370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_RS17375	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_RS17380	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CH64_RS17385	COG2871	sodium ion transport
CH64_RS17390	COG1477	protein flavinylation
CH64_RS17395	COG2991	Protein conserved in bacteria
CH64_RS17400	COG0584	glycerophosphoryl diester phosphodiesterase
CH64_RS17405	COG1181	Belongs to the D-alanine--D-alanine ligase family
CH64_RS17410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CH64_RS17415	COG2195	Cleaves the N-terminal amino acid of tripeptides
CH64_RS17425	COG1073	alpha beta
CH64_RS17435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CH64_RS17440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CH64_RS17460	COG2226	methyltransferase
CH64_RS17475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CH64_RS17485	COG2974	May be involved in recombination
CH64_RS17490	COG1940	carbohydrate kinase activity
CH64_RS17495	COG0419	ATPase involved in DNA repair
CH64_RS17500	COG0420	3'-5' exonuclease activity
CH64_RS17505	COG0745	RESPONSE REGULATOR receiver
CH64_RS17510	COG5002	protein histidine kinase activity
CH64_RS17530	COG0366	Alpha amylase catalytic
CH64_RS17545	COG0450	alkyl hydroperoxide reductase
CH64_RS17550	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
CH64_RS17560	COG0343	queuine tRNA-ribosyltransferase activity
CH64_RS17565	COG1862	Preprotein translocase
CH64_RS17570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH64_RS17575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CH64_RS17585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CH64_RS17590	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH64_RS17590	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CH64_RS17600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CH64_RS17605	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CH64_RS17610	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CH64_RS17615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CH64_RS17620	COG0142	geranyltranstransferase activity
CH64_RS17625	COG1722	exodeoxyribonuclease VII activity
CH64_RS17630	COG0301	tRNA thio-modification
CH64_RS17630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CH64_RS17635	COG0693	protein deglycase activity
CH64_RS17640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CH64_RS17645	COG1666	GTP binding
CH64_RS17650	COG2814	Major facilitator Superfamily
CH64_RS17655	COG0109	protoheme IX farnesyltransferase activity
CH64_RS17660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CH64_RS17665	COG1845	cytochrome c oxidase, subunit III
CH64_RS17670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CH64_RS17675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CH64_RS17685	COG2223	nitrite transmembrane transporter activity
CH64_RS17690	COG3056	Lipoprotein
CH64_RS17695	COG0271	Belongs to the BolA IbaG family
CH64_RS17700	COG0544	peptidyl-prolyl cis-trans isomerase activity
CH64_RS17710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CH64_RS17715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CH64_RS17720	COG0776	regulation of translation
CH64_RS17725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CH64_RS17730	COG1555	photosystem II stabilization
CH64_RS17735	COG0824	Thioesterase
CH64_RS17740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CH64_RS17745	COG4533	DNA binding
CH64_RS17750	COG0561	phosphatase activity
CH64_RS17760	COG1522	sequence-specific DNA binding
CH64_RS17765	COG1132	(ABC) transporter
CH64_RS17770	COG1132	(ABC) transporter
CH64_RS17775	COG0347	Belongs to the P(II) protein family
CH64_RS17780	COG0004	ammonium transporteR
CH64_RS17785	COG1946	Acyl-CoA thioesterase
CH64_RS17790	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CH64_RS17795	COG3695	enzyme binding
CH64_RS17815	COG1121	(ABC) transporter
CH64_RS17820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CH64_RS17825	COG0803	Belongs to the bacterial solute-binding protein 9 family
CH64_RS17830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CH64_RS17835	COG0254	rRNA binding
CH64_RS17840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CH64_RS17845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS17850	COG1309	transcriptional regulator
CH64_RS17855	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CH64_RS17860	COG1196	nuclear chromosome segregation
CH64_RS17860	COG3264	Mechanosensitive ion channel
CH64_RS17875	COG2832	Protein of unknown function (DUF454)
CH64_RS17880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CH64_RS17895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CH64_RS17905	COG0326	Molecular chaperone. Has ATPase activity
CH64_RS17910	COG0563	adenylate kinase activity
CH64_RS17915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CH64_RS17920	COG2244	polysaccharide biosynthetic process
CH64_RS17925	COG1215	transferase activity, transferring glycosyl groups
CH64_RS17930	COG0438	transferase activity, transferring glycosyl groups
CH64_RS17940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CH64_RS17960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CH64_RS17965	COG4651	solute:proton antiporter activity
CH64_RS17965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CH64_RS17970	COG2223	nitrite transmembrane transporter activity
CH64_RS17975	COG0737	Belongs to the 5'-nucleotidase family
CH64_RS17980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CH64_RS17985	COG3735	TraB family
CH64_RS17990	COG2217	Heavy metal translocating P-type atpase
CH64_RS17995	COG0789	Transcriptional regulator
CH64_RS18000	COG1585	Membrane protein implicated in regulation of membrane protease activity
CH64_RS18005	COG0330	HflC and HflK could
CH64_RS18010	COG3118	belongs to the thioredoxin family
CH64_RS18015	COG0300	oxidoreductase activity
CH64_RS18020	COG2755	lipolytic protein G-D-S-L family
CH64_RS18025	COG4181	ATPase activity
CH64_RS18030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CH64_RS18035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CH64_RS18040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CH64_RS18045	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CH64_RS18050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CH64_RS18055	COG0215	cysteine-tRNA ligase activity
CH64_RS18060	COG2501	S4 domain
CH64_RS18065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CH64_RS18075	COG0582	viral genome integration into host DNA
CH64_RS18080	COG0582	viral genome integration into host DNA
CH64_RS18125	COG3596	GTP binding
CH64_RS18165	COG0582	viral genome integration into host DNA
CH64_RS18170	COG1598	PFAM Uncharacterised protein family UPF0150
CH64_RS18185	COG3772	lysozyme
CH64_RS18220	COG0582	viral genome integration into host DNA
CH64_RS18275	COG3210	domain, Protein
CH64_RS18280	COG2831	hemolysin activation secretion protein
CH64_RS18290	COG5265	(ABC) transporter
CH64_RS18310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CH64_RS18320	COG2197	response regulator
CH64_RS18325	COG1278	Cold shock
CH64_RS18340	COG3706	GGDEF domain
CH64_RS18350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CH64_RS18355	COG0321	lipoyl(octanoyl) transferase activity
CH64_RS18360	COG2921	Belongs to the UPF0250 family
CH64_RS18365	COG1686	Belongs to the peptidase S11 family
CH64_RS18370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CH64_RS18375	COG0772	Belongs to the SEDS family
CH64_RS18380	COG0768	penicillin binding
CH64_RS18390	COG0799	negative regulation of ribosome biogenesis
CH64_RS18395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CH64_RS18400	COG1466	dna polymerase III delta subunit
CH64_RS18405	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CH64_RS18410	COG0495	leucyl-tRNA aminoacylation
CH64_RS18415	COG2888	peptidyl-tyrosine sulfation
CH64_RS18420	COG1126	abc transporter atp-binding protein
CH64_RS18425	COG0765	amino acid transport
CH64_RS18430	COG0765	amino acid transport
CH64_RS18445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CH64_RS18450	COG4535	Mg2 and Co2 transporter CorC
CH64_RS18455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CH64_RS18460	COG1702	phosphate starvation-inducible protein PhoH
CH64_RS18465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CH64_RS18470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CH64_RS18505	COG0367	asparagine synthase
CH64_RS18510	COG0647	UMP catabolic process
CH64_RS18515	COG1846	Transcriptional regulator
CH64_RS18515	COG1940	carbohydrate kinase activity
CH64_RS18520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CH64_RS18530	COG2190	(PTS) system
CH64_RS18530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CH64_RS18530	COG1263	PTS System
CH64_RS18535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CH64_RS18555	COG0735	belongs to the Fur family
CH64_RS18565	COG0840	transmembrane signaling receptor activity
CH64_RS18575	COG0596	Alpha beta hydrolase
CH64_RS18580	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CH64_RS18585	COG0033	Phosphoglucomutase
CH64_RS18600	COG0745	RESPONSE REGULATOR receiver
CH64_RS18605	COG2205	protein histidine kinase activity
CH64_RS18610	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CH64_RS18615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CH64_RS18635	COG3272	Protein of unknown function (DUF1722)
CH64_RS18645	COG5212	phosphodiesterase
CH64_RS18650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CH64_RS18655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CH64_RS18660	COG1984	allophanate hydrolase subunit 2
CH64_RS18665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CH64_RS18685	COG0372	Belongs to the citrate synthase family
CH64_RS18695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CH64_RS18700	COG1053	succinate dehydrogenase
CH64_RS18710	COG0567	Dehydrogenase, E1 component
CH64_RS18715	COG0508	dehydrogenase complex catalyzes the overall conversion of
CH64_RS18725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CH64_RS18730	COG0737	Belongs to the 5'-nucleotidase family
CH64_RS18735	COG1271	oxidase subunit
CH64_RS18740	COG1294	oxidase, subunit
CH64_RS18745	COG4890	Cyd operon protein YbgT
CH64_RS18750	COG3790	cyd operon protein YbgE
CH64_RS18755	COG0824	Thioesterase
CH64_RS18760	COG0811	peptide transport
CH64_RS18765	COG0848	biopolymer transport protein
CH64_RS18770	COG3064	Membrane
CH64_RS18770	COG3064	Membrane
CH64_RS18775	COG0823	Involved in the tonB-independent uptake of proteins
CH64_RS18780	COG2885	chlorophyll binding
CH64_RS18785	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CH64_RS18820	COG1230	cation diffusion facilitator family transporter
CH64_RS18825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CH64_RS18830	COG0588	phosphoglycerate mutase activity
CH64_RS18840	COG2017	converts alpha-aldose to the beta-anomer
CH64_RS18845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CH64_RS18850	COG1085	galactose-1-phosphate uridylyltransferase
CH64_RS18855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CH64_RS18865	COG1119	ATPase activity
CH64_RS18870	COG3585	molybdate ion transport
CH64_RS18870	COG2005	Transcriptional regulator
CH64_RS18880	COG0725	ABC transporter, periplasmic molybdate-binding protein
CH64_RS18885	COG4149	molybdate abc transporter
CH64_RS18895	COG0561	phosphatase activity
CH64_RS18900	COG2706	6-phosphogluconolactonase activity
CH64_RS18910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CH64_RS18915	COG0156	8-amino-7-oxononanoate synthase activity
CH64_RS18920	COG2226	methyltransferase
CH64_RS18935	COG0556	nucleotide-excision repair
CH64_RS18940	COG4628	conserved protein (DUF2132)
CH64_RS18945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CH64_RS18950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CH64_RS18955	COG0315	cyclic pyranopterin monophosphate synthase activity
CH64_RS18960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CH64_RS18965	COG0314	molybdopterin synthase activity
CH64_RS18970	COG0670	Belongs to the BI1 family
CH64_RS18975	COG0842	Transport permease protein
CH64_RS18980	COG0842	Transport permease protein
CH64_RS18985	COG1131	(ABC) transporter
CH64_RS18990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CH64_RS18995	COG1309	transcriptional regulator
CH64_RS19005	COG0513	Belongs to the DEAD box helicase family
CH64_RS19010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CH64_RS19015	COG2239	Acts as a magnesium transporter
CH64_RS19030	COG1686	Belongs to the peptidase S11 family
CH64_RS19035	COG0277	FAD linked oxidase domain protein
CH64_RS19055	COG2261	transglycosylase associated protein
CH64_RS19060	COG4807	Protein conserved in bacteria
CH64_RS19090	COG2897	thiosulfate sulfurtransferase activity
CH64_RS19105	COG1732	Glycine betaine
CH64_RS19110	COG1174	glycine betaine transport
CH64_RS19115	COG1125	glycine betaine transport
CH64_RS19120	COG1174	glycine betaine transport
CH64_RS19130	COG0697	spore germination
CH64_RS19140	COG1199	ATP-dependent helicase activity
CH64_RS19145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CH64_RS19150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CH64_RS19170	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CH64_RS19180	COG1126	abc transporter atp-binding protein
CH64_RS19185	COG0765	amino acid transport
CH64_RS19190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CH64_RS19195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CH64_RS19200	COG0783	Belongs to the Dps family
CH64_RS19205	COG4106	trans-aconitate 2-methyltransferase activity
CH64_RS19225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CH64_RS19245	COG0488	(ABC) transporter
CH64_RS19250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CH64_RS19270	COG1136	(ABC) transporter
CH64_RS19285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CH64_RS19295	COG3321	synthase
CH64_RS19295	COG1028	Short-chain dehydrogenase reductase Sdr
CH64_RS19295	COG0604	alcohol dehydrogenase
CH64_RS19325	COG3468	outer membrane autotransporter barrel domain protein
CH64_RS19345	COG3210	domain, Protein
CH64_RS19350	COG3210	domain, Protein
CH64_RS19355	COG3210	domain, Protein
CH64_RS19370	COG3033	Beta-eliminating lyase