locus-tag	class	description
ND440_RS00010	COG0592	DNA-directed DNA polymerase activity
ND440_RS00020	COG0187	DNA topoisomerase II activity
ND440_RS00025	COG0561	phosphatase activity
ND440_RS00030	COG0823	Involved in the tonB-independent uptake of proteins
ND440_RS00035	COG5645	(Lipo)protein
ND440_RS00050	COG0569	domain protein
ND440_RS00050	COG2985	domain, Protein
ND440_RS00055	COG3977	Valine--pyruvate aminotransferase
ND440_RS00060	COG2885	chlorophyll binding
ND440_RS00080	COG2818	Glycosylase
ND440_RS00130	COG2213	PTS system mannitol-specific
ND440_RS00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_RS00140	COG3722	fumarate hydratase activity
ND440_RS00150	COG2258	MOSC domain
ND440_RS00155	COG0840	transmembrane signaling receptor activity
ND440_RS00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND440_RS00175	COG0437	4 iron, 4 sulfur cluster binding
ND440_RS00180	COG2864	formate dehydrogenase
ND440_RS00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND440_RS00195	COG3276	selenocysteine insertion sequence binding
ND440_RS00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND440_RS00210	COG3274	enterobacterial common antigen metabolic process
ND440_RS00220	COG0582	viral genome integration into host DNA
ND440_RS00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND440_RS00260	COG2986	histidine ammonia-lyase
ND440_RS00280	COG2194	sulfuric ester hydrolase activity
ND440_RS00285	COG2197	response regulator
ND440_RS00290	COG3851	Histidine kinase
ND440_RS00295	COG2271	Major facilitator Superfamily
ND440_RS00305	COG0747	negative chemotaxis
ND440_RS00310	COG0601	transmembrane transport
ND440_RS00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND440_RS00320	COG0444	Belongs to the ABC transporter superfamily
ND440_RS00325	COG4608	Belongs to the ABC transporter superfamily
ND440_RS00330	COG2194	sulfuric ester hydrolase activity
ND440_RS00355	COG1215	transferase activity, transferring glycosyl groups
ND440_RS00360	COG1215	transferase activity, transferring glycosyl groups
ND440_RS00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND440_RS00370	COG3118	belongs to the thioredoxin family
ND440_RS00370	COG0457	Tetratricopeptide repeat
ND440_RS00375	COG2199	diguanylate cyclase activity
ND440_RS00375	COG2200	EAL domain
ND440_RS00380	COG1301	dicarboxylic acid transport
ND440_RS00385	COG0612	Peptidase, M16
ND440_RS00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND440_RS00395	COG1942	4-Oxalocrotonate Tautomerase
ND440_RS00400	COG2200	EAL domain
ND440_RS00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND440_RS00410	COG1295	ribonuclease BN
ND440_RS00420	COG1301	dicarboxylic acid transport
ND440_RS00425	COG0626	cystathionine gamma-synthase activity
ND440_RS00465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_RS00470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND440_RS00475	COG0339	signal peptide processing
ND440_RS00480	COG0742	ribosomal rna small subunit methyltransferase
ND440_RS00490	COG0589	response to stress
ND440_RS00500	COG0306	phosphate transporter
ND440_RS00505	COG2081	HI0933 family
ND440_RS00515	COG1247	-acetyltransferase
ND440_RS00520	COG1741	Belongs to the pirin family
ND440_RS00525	COG1609	Transcriptional regulator
ND440_RS00530	COG2610	gluconate transmembrane transporter activity
ND440_RS00535	COG3265	gluconokinase activity
ND440_RS00540	COG2095	MarC family integral membrane protein
ND440_RS00545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND440_RS00550	COG3275	phosphorelay sensor kinase activity
ND440_RS00555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND440_RS00560	COG1523	belongs to the glycosyl hydrolase 13 family
ND440_RS00565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND440_RS00570	COG0297	glycogen (starch) synthase activity
ND440_RS00575	COG0058	SHG alpha-glucan phosphorylase activity
ND440_RS00580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND440_RS00585	COG1349	DNA-binding transcription factor activity
ND440_RS00590	COG0705	Rhomboid family
ND440_RS00600	COG2909	trisaccharide binding
ND440_RS00605	COG0058	SHG alpha-glucan phosphorylase activity
ND440_RS00610	COG1640	4-alpha-glucanotransferase
ND440_RS00620	COG1040	competence protein
ND440_RS00625	COG0596	Alpha beta hydrolase
ND440_RS00645	COG1918	ferrous iron import across plasma membrane
ND440_RS00650	COG2183	response to ionizing radiation
ND440_RS00675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND440_RS00690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND440_RS00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND440_RS00705	COG1011	Hydrolase
ND440_RS00715	COG0494	nUDIX hydrolase
ND440_RS00720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND440_RS00745	COG4796	Type ii and iii secretion system protein
ND440_RS00750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND440_RS00770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND440_RS00780	COG0180	Tryptophanyl-tRNA synthetase
ND440_RS00800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND440_RS00805	COG0402	S-adenosylhomocysteine deaminase activity
ND440_RS00810	COG0738	Major facilitator superfamily
ND440_RS00825	COG1609	Transcriptional regulator
ND440_RS00830	COG1486	melibiose metabolic process
ND440_RS00835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND440_RS00850	COG1289	transmembrane transporter activity
ND440_RS00855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND440_RS00885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND440_RS00890	COG3954	Phosphoribulokinase
ND440_RS00900	COG0429	hydrolase of the alpha beta-hydrolase fold
ND440_RS00910	COG0859	PFAM glycosyl transferase family 9
ND440_RS00915	COG1216	Glycosyl transferase, family 2
ND440_RS00920	COG0488	(ABC) transporter
ND440_RS00925	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND440_RS00935	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND440_RS00940	COG1047	Peptidyl-prolyl cis-trans
ND440_RS00950	COG0545	Peptidyl-prolyl cis-trans isomerase
ND440_RS00955	COG2964	Protein conserved in bacteria
ND440_RS00965	COG2923	Belongs to the DsrF TusC family
ND440_RS00970	COG2168	tRNA wobble position uridine thiolation
ND440_RS00975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND440_RS00980	COG0049	tRNA binding
ND440_RS00990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND440_RS01005	COG0051	transcription antitermination factor activity, RNA binding
ND440_RS01010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND440_RS01020	COG0089	rRNA binding
ND440_RS01025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND440_RS01030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND440_RS01035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND440_RS01045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND440_RS01050	COG0255	Belongs to the universal ribosomal protein uL29 family
ND440_RS01055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND440_RS01060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND440_RS01070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND440_RS01095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND440_RS01100	COG1841	ribosomal large subunit assembly
ND440_RS01105	COG0200	Binds to the 23S rRNA
ND440_RS01110	COG0201	protein transport
ND440_RS01115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND440_RS01120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND440_RS01130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND440_RS01140	COG0203	ribosomal protein L17
ND440_RS01145	COG0789	Transcriptional regulator
ND440_RS01150	COG3036	rescue of stalled ribosome
ND440_RS01155	COG1970	mechanosensitive ion channel activity
ND440_RS01165	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND440_RS01165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND440_RS01170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND440_RS01175	COG0242	peptide deformylase activity
ND440_RS01180	COG0758	DNA mediated transformation
ND440_RS01185	COG2922	Belongs to the Smg family
ND440_RS01190	COG0551	DNA topoisomerase type I activity
ND440_RS01195	COG0009	L-threonylcarbamoyladenylate synthase
ND440_RS01205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND440_RS01230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND440_RS01275	COG0250	Participates in transcription elongation, termination and antitermination
ND440_RS01280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND440_RS01290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND440_RS01295	COG0222	ribosome binding
ND440_RS01300	COG0085	RNA polymerase activity
ND440_RS01305	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND440_RS01315	COG2022	thiamine diphosphate biosynthetic process
ND440_RS01320	COG2104	thiamine diphosphate biosynthetic process
ND440_RS01325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND440_RS01340	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND440_RS01345	COG2816	NAD+ diphosphatase activity
ND440_RS01350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND440_RS01355	COG1515	deoxyribonuclease V activity
ND440_RS01375	COG0151	Belongs to the GarS family
ND440_RS01380	COG0138	bifunctional purine biosynthesis protein purh
ND440_RS01420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND440_RS01455	COG0583	DNA-binding transcription factor activity
ND440_RS01535	COG1222	aaa ATPase
ND440_RS01560	COG0527	aspartate kinase activity
ND440_RS01570	COG3223	Belongs to the PsiE family
ND440_RS01575	COG3833	ABC-type maltose transport systems, permease component
ND440_RS01580	COG1175	transmembrane transport
ND440_RS01585	COG2182	Extracellular solute-binding protein
ND440_RS01600	COG4580	involved in the transport of maltose and maltodextrins
ND440_RS01620	COG2937	Belongs to the GPAT DAPAT family
ND440_RS01625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND440_RS01630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND440_RS01635	COG0735	belongs to the Fur family
ND440_RS01640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND440_RS01650	COG0604	alcohol dehydrogenase
ND440_RS01665	COG1448	Aminotransferase
ND440_RS01670	COG2315	Protein conserved in bacteria
ND440_RS01675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND440_RS01690	COG2252	PERMEase
ND440_RS01695	COG0025	NhaP-type Na H and K H
ND440_RS01700	COG0583	DNA-binding transcription factor activity
ND440_RS01705	COG1380	Effector of murein hydrolase LrgA
ND440_RS01710	COG1346	cytolysis
ND440_RS01720	COG1560	Kdo2-lipid A biosynthetic process
ND440_RS01730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND440_RS01735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND440_RS01740	COG2264	protein methyltransferase activity
ND440_RS01745	COG4145	pantothenate transmembrane transporter activity
ND440_RS01750	COG3924	membrane
ND440_RS01755	COG0439	Biotin carboxylase
ND440_RS01760	COG0511	ligase activity, forming carbon-carbon bonds
ND440_RS01770	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND440_RS01775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND440_RS01780	COG0604	alcohol dehydrogenase
ND440_RS01785	COG2199	diguanylate cyclase activity
ND440_RS01785	COG2200	EAL domain
ND440_RS01790	COG1077	Cell shape determining protein MreB Mrl
ND440_RS01795	COG1792	Involved in formation and maintenance of cell shape
ND440_RS01800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND440_RS01805	COG0424	maF-like protein
ND440_RS01815	COG3164	Protein of unknown function
ND440_RS01820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_RS01825	COG0312	modulator of DNA gyrase
ND440_RS01830	COG0583	DNA-binding transcription factor activity
ND440_RS01840	COG1566	PFAM secretion protein HlyD family protein
ND440_RS01845	COG1289	transmembrane transporter activity
ND440_RS01855	COG4290	ribonuclease
ND440_RS01860	COG2732	(Barnase) inhibitor
ND440_RS01865	COG3028	Belongs to the UPF0307 family
ND440_RS01870	COG0312	modulator of DNA gyrase
ND440_RS01875	COG3783	Cytochrome b(562)
ND440_RS01880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND440_RS01890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND440_RS01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_RS01900	COG1263	PTS System
ND440_RS01905	COG0366	Alpha amylase catalytic
ND440_RS01915	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND440_RS01920	COG0540	Belongs to the ATCase OTCase family
ND440_RS01925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_RS01945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND440_RS01950	COG1137	ATPase activity
ND440_RS01955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND440_RS01960	COG3117	lipopolysaccharide transmembrane transporter activity
ND440_RS01965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND440_RS01970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND440_RS01970	COG0517	IMP dehydrogenase activity
ND440_RS01975	COG0530	calcium, potassium:sodium antiporter activity
ND440_RS01980	COG1127	ABC transporter
ND440_RS01985	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND440_RS01990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND440_RS01995	COG2854	intermembrane phospholipid transfer
ND440_RS02000	COG3113	response to antibiotic
ND440_RS02005	COG5007	Belongs to the BolA IbaG family
ND440_RS02010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND440_RS02020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND440_RS02025	COG3105	Protein conserved in bacteria
ND440_RS02030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND440_RS02035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND440_RS02040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND440_RS02045	COG0625	glutathione transferase activity
ND440_RS02050	COG2969	positive regulation of protein catabolic process
ND440_RS02060	COG0493	'glutamate synthase
ND440_RS02065	COG0070	glutamate synthase
ND440_RS02065	COG0067	glutamate synthase
ND440_RS02065	COG0069	glutamate synthase activity
ND440_RS02070	COG1242	4 iron, 4 sulfur cluster binding
ND440_RS02085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND440_RS02095	COG2823	Periplasmic or secreted lipoprotein
ND440_RS02100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND440_RS02130	COG1741	Belongs to the pirin family
ND440_RS02135	COG0583	DNA-binding transcription factor activity
ND440_RS02140	COG2259	Doxx family
ND440_RS02150	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND440_RS02155	COG4575	ribosome binding
ND440_RS02170	COG0586	Pfam SNARE associated Golgi protein
ND440_RS02185	COG2271	Major facilitator Superfamily
ND440_RS02200	COG2721	sulfolactate sulfo-lyase activity
ND440_RS02210	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND440_RS02215	COG0861	Integral membrane protein TerC family
ND440_RS02220	COG0673	inositol 2-dehydrogenase activity
ND440_RS02225	COG1451	nucleotide metabolic process
ND440_RS02240	COG1902	pentaerythritol trinitrate reductase activity
ND440_RS02240	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND440_RS02245	COG2831	hemolysin activation secretion protein
ND440_RS02250	COG3210	domain, Protein
ND440_RS02275	COG0463	Glycosyl transferase, family 2
ND440_RS02305	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_RS02415	COG0358	DNA primase activity
ND440_RS02420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND440_RS02425	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND440_RS02430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND440_RS02435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND440_RS02440	COG1968	undecaprenyl-diphosphatase activity
ND440_RS02445	COG0617	tRNA 3'-terminal CCA addition
ND440_RS02450	COG4991	sh3 domain protein
ND440_RS02455	COG3025	triphosphatase activity
ND440_RS02465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND440_RS02465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND440_RS02475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND440_RS02480	COG3384	dioxygenase
ND440_RS02485	COG0754	glutathionylspermidine amidase activity
ND440_RS02490	COG5463	Belongs to the UPF0441 family
ND440_RS02495	COG1538	Outer membrane efflux protein
ND440_RS02500	COG0494	nUDIX hydrolase
ND440_RS02505	COG3151	Protein conserved in bacteria
ND440_RS02510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND440_RS02515	COG3150	esterase
ND440_RS02520	COG0187	DNA topoisomerase II activity
ND440_RS02525	COG0583	DNA-binding transcription factor activity
ND440_RS02530	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND440_RS02535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ND440_RS02545	COG2132	Multicopper oxidase
ND440_RS02555	COG0656	L-ascorbic acid biosynthetic process
ND440_RS02560	COG1979	alcohol dehydrogenase
ND440_RS02565	COG2207	Transcriptional regulator
ND440_RS02570	COG0586	Pfam SNARE associated Golgi protein
ND440_RS02575	COG0626	cystathionine gamma-synthase activity
ND440_RS02580	COG0811	peptide transport
ND440_RS02585	COG0848	biopolymer transport protein
ND440_RS02635	COG4964	Belongs to the GSP D family
ND440_RS02660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND440_RS02665	COG4774	siderophore transport
ND440_RS02675	COG3251	PFAM MbtH domain protein
ND440_RS02680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND440_RS02690	COG1120	ATPase activity
ND440_RS02695	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_RS02700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_RS02710	COG4592	Periplasmic binding protein
ND440_RS02715	COG1169	isochorismate synthase
ND440_RS02720	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND440_RS02725	COG3433	isochorismatase activity
ND440_RS02725	COG1535	isochorismatase
ND440_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_RS02745	COG0814	amino acid
ND440_RS02750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND440_RS02755	COG1882	Formate acetyltransferase
ND440_RS02760	COG1105	Belongs to the carbohydrate kinase PfkB family
ND440_RS02795	COG0741	lytic transglycosylase activity
ND440_RS02800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND440_RS02805	COG1194	a g-specific adenine glycosylase
ND440_RS02815	COG3171	Protein conserved in bacteria
ND440_RS02830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND440_RS02835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND440_RS02840	COG1872	DUF167
ND440_RS02845	COG0762	integral membrane protein
ND440_RS02850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND440_RS02855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND440_RS02860	COG2805	Type II/IV secretion system protein
ND440_RS02870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_RS02875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND440_RS02880	COG1678	Uncharacterized ACR, COG1678
ND440_RS02885	COG0189	ligase activity
ND440_RS02890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND440_RS02895	COG2356	endonuclease I
ND440_RS02900	COG3091	SprT-like family
ND440_RS02905	COG0640	Transcriptional regulator
ND440_RS02920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND440_RS02925	COG1166	arginine decarboxylase activity
ND440_RS02935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND440_RS02940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND440_RS02945	COG0126	phosphoglycerate kinase activity
ND440_RS02950	COG0191	fructose-bisphosphate aldolase activity
ND440_RS02960	COG1279	arginine transmembrane transporter activity
ND440_RS02975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND440_RS02980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND440_RS02985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND440_RS02995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND440_RS03005	COG0006	proline dipeptidase activity
ND440_RS03010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND440_RS03015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND440_RS03020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND440_RS03040	COG1272	protein, Hemolysin III
ND440_RS03050	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND440_RS03060	COG0716	FMN binding
ND440_RS03065	COG4974	Belongs to the 'phage' integrase family
ND440_RS03070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND440_RS03075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND440_RS03085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND440_RS03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND440_RS03100	COG1127	ABC transporter
ND440_RS03130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND440_RS03140	COG2165	general secretion pathway protein
ND440_RS03195	COG0583	DNA-binding transcription factor activity
ND440_RS03200	COG0583	DNA-binding transcription factor activity
ND440_RS03210	COG1609	Transcriptional regulator
ND440_RS03215	COG0318	PFAM AMP-dependent synthetase and ligase
ND440_RS03215	COG0204	Acyl-transferase
ND440_RS03220	COG0477	Major facilitator Superfamily
ND440_RS03225	COG0667	Aldo Keto reductase
ND440_RS03230	COG0861	Integral membrane protein TerC family
ND440_RS03235	COG3066	DNA modification
ND440_RS03245	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND440_RS03250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND440_RS03275	COG4967	type IV pilus modification protein PilV
ND440_RS03280	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND440_RS03285	COG1025	Belongs to the peptidase M16 family
ND440_RS03290	COG1074	ATP-dependent DNA helicase activity
ND440_RS03295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND440_RS03300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND440_RS03300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND440_RS03305	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND440_RS03325	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND440_RS03330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND440_RS03335	COG2166	iron-sulfur cluster assembly
ND440_RS03340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND440_RS03350	COG0583	DNA-binding transcription factor activity
ND440_RS03355	COG2363	Small membrane protein
ND440_RS03360	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND440_RS03375	COG1611	Belongs to the LOG family
ND440_RS03390	COG3098	single-species biofilm formation
ND440_RS03395	COG0564	pseudouridine synthase activity
ND440_RS03410	COG2171	N-acyltransferase activity
ND440_RS03415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND440_RS03435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND440_RS03440	COG0528	UMP kinase activity
ND440_RS03460	COG0575	Belongs to the CDS family
ND440_RS03465	COG0750	zinc metalloprotease
ND440_RS03475	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND440_RS03480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND440_RS03500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND440_RS03505	COG0587	DNA-directed DNA polymerase activity
ND440_RS03510	COG0825	malonyl-CoA metabolic process
ND440_RS03525	COG0346	lactoylglutathione lyase activity
ND440_RS03540	COG4568	rho-dependent transcription termination
ND440_RS03550	COG4681	YaeQ
ND440_RS03560	COG3015	lipoprotein NlpE involved in copper resistance
ND440_RS03565	COG0442	prolyl-tRNA aminoacylation
ND440_RS03570	COG1720	tRNA m6t6A37 methyltransferase activity
ND440_RS03580	COG1464	Belongs to the NlpA lipoprotein family
ND440_RS03585	COG2011	ABC-type metal ion transport system permease component
ND440_RS03595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND440_RS03625	COG3021	interspecies interaction between organisms
ND440_RS03630	COG0741	lytic transglycosylase activity
ND440_RS03630	COG1388	LysM domain
ND440_RS03640	COG2226	methyltransferase
ND440_RS03650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND440_RS03660	COG1960	acyl-CoA dehydrogenase activity
ND440_RS03665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND440_RS03670	COG0121	glutamine amidotransferase
ND440_RS03675	COG3034	peptidoglycan biosynthetic process
ND440_RS03685	COG1805	sodium ion transport
ND440_RS03690	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND440_RS03695	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND440_RS03700	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND440_RS03710	COG1477	protein flavinylation
ND440_RS03715	COG2991	Protein conserved in bacteria
ND440_RS03725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND440_RS03730	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND440_RS03735	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND440_RS03740	COG1073	alpha beta
ND440_RS03755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND440_RS03790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND440_RS03810	COG4126	flavin adenine dinucleotide binding
ND440_RS03820	COG2974	May be involved in recombination
ND440_RS03825	COG1940	carbohydrate kinase activity
ND440_RS03830	COG0419	ATPase involved in DNA repair
ND440_RS03835	COG0420	3'-5' exonuclease activity
ND440_RS03840	COG0745	RESPONSE REGULATOR receiver
ND440_RS03845	COG5002	protein histidine kinase activity
ND440_RS03860	COG1113	amino acid transport
ND440_RS03865	COG0366	Alpha amylase catalytic
ND440_RS03870	COG0300	oxidoreductase activity
ND440_RS03875	COG0450	alkyl hydroperoxide reductase
ND440_RS03880	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND440_RS03895	COG1862	Preprotein translocase
ND440_RS03900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND440_RS03905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND440_RS03910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND440_RS03915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND440_RS03915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND440_RS03920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND440_RS03930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND440_RS03935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND440_RS03940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND440_RS03945	COG0142	geranyltranstransferase activity
ND440_RS03980	COG0693	protein deglycase activity
ND440_RS03985	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND440_RS03990	COG1666	GTP binding
ND440_RS03995	COG2814	Major facilitator Superfamily
ND440_RS04005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND440_RS04010	COG1845	cytochrome c oxidase, subunit III
ND440_RS04015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND440_RS04020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND440_RS04030	COG2223	nitrite transmembrane transporter activity
ND440_RS04035	COG3056	Lipoprotein
ND440_RS04040	COG0271	Belongs to the BolA IbaG family
ND440_RS04050	COG0740	serine-type endopeptidase activity
ND440_RS04055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND440_RS04060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND440_RS04065	COG0776	regulation of translation
ND440_RS04070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND440_RS04075	COG1555	photosystem II stabilization
ND440_RS04080	COG0824	Thioesterase
ND440_RS04085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND440_RS04090	COG4533	DNA binding
ND440_RS04105	COG1522	sequence-specific DNA binding
ND440_RS04110	COG1132	(ABC) transporter
ND440_RS04115	COG1132	(ABC) transporter
ND440_RS04120	COG0347	Belongs to the P(II) protein family
ND440_RS04125	COG0004	ammonium transporteR
ND440_RS04130	COG1946	Acyl-CoA thioesterase
ND440_RS04135	COG3695	enzyme binding
ND440_RS04160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND440_RS04165	COG0254	rRNA binding
ND440_RS04170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_RS04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_RS04180	COG1309	transcriptional regulator
ND440_RS04185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND440_RS04190	COG3264	Mechanosensitive ion channel
ND440_RS04190	COG1196	nuclear chromosome segregation
ND440_RS04205	COG2832	Protein of unknown function (DUF454)
ND440_RS04210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND440_RS04250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND440_RS04255	COG0326	Molecular chaperone. Has ATPase activity
ND440_RS04270	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND440_RS04275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND440_RS04280	COG4651	solute:proton antiporter activity
ND440_RS04280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND440_RS04285	COG0737	Belongs to the 5'-nucleotidase family
ND440_RS04290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND440_RS04295	COG3735	TraB family
ND440_RS04300	COG2217	Heavy metal translocating P-type atpase
ND440_RS04305	COG0789	Transcriptional regulator
ND440_RS04310	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND440_RS04315	COG0330	HflC and HflK could
ND440_RS04320	COG3118	belongs to the thioredoxin family
ND440_RS04325	COG0300	oxidoreductase activity
ND440_RS04330	COG2755	lipolytic protein G-D-S-L family
ND440_RS04335	COG4181	ATPase activity
ND440_RS04340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND440_RS04345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND440_RS04350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND440_RS04355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND440_RS04360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND440_RS04385	COG3188	usher protein
ND440_RS04390	COG3121	Chaperone
ND440_RS04420	COG2501	S4 domain
ND440_RS04425	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND440_RS04440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND440_RS04445	COG1393	Belongs to the ArsC family
ND440_RS04455	COG1022	Amp-dependent synthetase and ligase
ND440_RS04480	COG3038	cytochrome b561
ND440_RS04510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND440_RS04520	COG1215	transferase activity, transferring glycosyl groups
ND440_RS04540	COG3250	beta-galactosidase activity
ND440_RS04555	COG1309	transcriptional regulator
ND440_RS04585	COG2197	response regulator
ND440_RS04590	COG1278	Cold shock
ND440_RS04610	COG3706	GGDEF domain
ND440_RS04620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND440_RS04630	COG2921	Belongs to the UPF0250 family
ND440_RS04635	COG1686	Belongs to the peptidase S11 family
ND440_RS04640	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND440_RS04645	COG0772	Belongs to the SEDS family
ND440_RS04650	COG0768	penicillin binding
ND440_RS04655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND440_RS04660	COG0799	negative regulation of ribosome biogenesis
ND440_RS04665	COG0582	viral genome integration into host DNA
ND440_RS04725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND440_RS04790	COG0305	Participates in initiation and elongation during chromosome replication
ND440_RS04815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ND440_RS04890	COG0616	signal peptide processing
ND440_RS04930	COG4386	tail sheath protein
ND440_RS04970	COG3299	homolog of phage Mu protein gp47
ND440_RS04985	COG5301	cellulose 1,4-beta-cellobiosidase activity
ND440_RS04995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND440_RS05000	COG1466	dna polymerase III delta subunit
ND440_RS05005	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND440_RS05015	COG2888	peptidyl-tyrosine sulfation
ND440_RS05020	COG1126	abc transporter atp-binding protein
ND440_RS05025	COG0765	amino acid transport
ND440_RS05030	COG0765	amino acid transport
ND440_RS05040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND440_RS05045	COG4535	Mg2 and Co2 transporter CorC
ND440_RS05050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND440_RS05055	COG1702	phosphate starvation-inducible protein PhoH
ND440_RS05060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND440_RS05065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND440_RS05100	COG0367	asparagine synthase
ND440_RS05105	COG0647	UMP catabolic process
ND440_RS05110	COG1940	carbohydrate kinase activity
ND440_RS05110	COG1846	Transcriptional regulator
ND440_RS05115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND440_RS05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_RS05125	COG2190	(PTS) system
ND440_RS05125	COG1263	PTS System
ND440_RS05150	COG0735	belongs to the Fur family
ND440_RS05160	COG0840	transmembrane signaling receptor activity
ND440_RS05170	COG0596	Alpha beta hydrolase
ND440_RS05175	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND440_RS05180	COG0033	Phosphoglucomutase
ND440_RS05190	COG0745	RESPONSE REGULATOR receiver
ND440_RS05195	COG2205	protein histidine kinase activity
ND440_RS05200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND440_RS05205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND440_RS05225	COG3272	Protein of unknown function (DUF1722)
ND440_RS05230	COG0415	Belongs to the DNA photolyase family
ND440_RS05235	COG5212	phosphodiesterase
ND440_RS05240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND440_RS05245	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND440_RS05250	COG1984	allophanate hydrolase subunit 2
ND440_RS05255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND440_RS05290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND440_RS05295	COG1053	succinate dehydrogenase
ND440_RS05300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND440_RS05305	COG0567	Dehydrogenase, E1 component
ND440_RS05310	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND440_RS05315	COG0045	succinate-CoA ligase (ADP-forming) activity
ND440_RS05320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND440_RS05325	COG0737	Belongs to the 5'-nucleotidase family
ND440_RS05330	COG1271	oxidase subunit
ND440_RS05335	COG1294	oxidase, subunit
ND440_RS05340	COG4890	Cyd operon protein YbgT
ND440_RS05345	COG3790	cyd operon protein YbgE
ND440_RS05350	COG0824	Thioesterase
ND440_RS05355	COG0811	peptide transport
ND440_RS05360	COG0848	biopolymer transport protein
ND440_RS05365	COG3064	Membrane
ND440_RS05365	COG3064	Membrane
ND440_RS05370	COG0823	Involved in the tonB-independent uptake of proteins
ND440_RS05375	COG2885	chlorophyll binding
ND440_RS05380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND440_RS05410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND440_RS05420	COG2205	protein histidine kinase activity
ND440_RS05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_RS05430	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND440_RS05435	COG0588	phosphoglycerate mutase activity
ND440_RS05445	COG2017	converts alpha-aldose to the beta-anomer
ND440_RS05455	COG1085	galactose-1-phosphate uridylyltransferase
ND440_RS05460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND440_RS05475	COG3585	molybdate ion transport
ND440_RS05475	COG2005	Transcriptional regulator
ND440_RS05485	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND440_RS05490	COG4149	molybdate abc transporter
ND440_RS05500	COG0561	phosphatase activity
ND440_RS05505	COG2706	6-phosphogluconolactonase activity
ND440_RS05520	COG0156	8-amino-7-oxononanoate synthase activity
ND440_RS05525	COG2226	methyltransferase
ND440_RS05540	COG0556	nucleotide-excision repair
ND440_RS05545	COG4628	conserved protein (DUF2132)
ND440_RS05560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_RS05565	COG1120	ATPase activity
ND440_RS05570	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND440_RS05575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND440_RS05585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND440_RS05590	COG0314	molybdopterin synthase activity
ND440_RS05595	COG0670	Belongs to the BI1 family
ND440_RS05600	COG0842	Transport permease protein
ND440_RS05605	COG0842	Transport permease protein
ND440_RS05610	COG1131	(ABC) transporter
ND440_RS05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_RS05620	COG1309	transcriptional regulator
ND440_RS05625	COG0513	Belongs to the DEAD box helicase family
ND440_RS05630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND440_RS05640	COG1686	Belongs to the peptidase S11 family
ND440_RS05645	COG0277	FAD linked oxidase domain protein
ND440_RS05665	COG2261	transglycosylase associated protein
ND440_RS05675	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND440_RS05685	COG3639	organic phosphonate transmembrane transporter activity
ND440_RS05690	COG4807	Protein conserved in bacteria
ND440_RS05695	COG2897	thiosulfate sulfurtransferase activity
ND440_RS05700	COG1732	Glycine betaine
ND440_RS05705	COG1174	glycine betaine transport
ND440_RS05710	COG1125	glycine betaine transport
ND440_RS05715	COG1174	glycine betaine transport
ND440_RS05720	COG0531	amino acid
ND440_RS05725	COG1982	Orn Lys Arg decarboxylase major
ND440_RS05735	COG0697	spore germination
ND440_RS05750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND440_RS05755	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND440_RS05760	COG1126	abc transporter atp-binding protein
ND440_RS05765	COG0765	amino acid transport
ND440_RS05770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_RS05790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND440_RS05795	COG2239	Acts as a magnesium transporter
ND440_RS05800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND440_RS05805	COG0488	(ABC) transporter
ND440_RS05810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND440_RS05815	COG0303	'Molybdopterin
ND440_RS05835	COG0583	DNA-binding transcription factor activity
ND440_RS05840	COG0477	Major facilitator Superfamily
ND440_RS05845	COG0302	gtp cyclohydrolase
ND440_RS05850	COG2311	Membrane
ND440_RS05875	COG2949	membrane
ND440_RS05880	COG0281	malic enzyme
ND440_RS05890	COG0583	DNA-binding transcription factor activity
ND440_RS05900	COG1346	cytolysis
ND440_RS05905	COG1380	Effector of murein hydrolase LrgA
ND440_RS05915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND440_RS05915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND440_RS05920	COG0489	protein tyrosine kinase activity
ND440_RS05925	COG0572	uridine kinase
ND440_RS05930	COG0717	Belongs to the dCTP deaminase family
ND440_RS05935	COG2982	Protein involved in outer membrane biogenesis
ND440_RS05940	COG3069	C4-dicarboxylate transmembrane transporter activity
ND440_RS05945	COG1253	flavin adenine dinucleotide binding
ND440_RS05950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND440_RS05955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND440_RS05960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND440_RS05970	COG0140	phosphoribosyl-ATP diphosphatase activity
ND440_RS05970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND440_RS05980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND440_RS05995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND440_RS06000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND440_RS06015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND440_RS06020	COG0625	glutathione transferase activity
ND440_RS06035	COG0626	cystathionine gamma-synthase activity
ND440_RS06045	COG1686	Belongs to the peptidase S11 family
ND440_RS06050	COG1760	l-serine dehydratase
ND440_RS06055	COG0814	amino acid
ND440_RS06060	COG1349	DNA-binding transcription factor activity
ND440_RS06070	COG0671	phosphoesterase, PA-phosphatase related
ND440_RS06080	COG2985	domain, Protein
ND440_RS06080	COG0569	domain protein
ND440_RS06100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND440_RS06105	COG3842	ATPase activity
ND440_RS06110	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND440_RS06115	COG1177	transmembrane transport
ND440_RS06130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_RS06135	COG4160	amino acid transport
ND440_RS06140	COG4215	(ABC) transporter
ND440_RS06145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_RS06150	COG1126	abc transporter atp-binding protein
ND440_RS06160	COG0393	Putative heavy-metal-binding
ND440_RS06165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND440_RS06170	COG0702	epimerase
ND440_RS06175	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND440_RS06180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND440_RS06185	COG1151	hydroxylamine reductase activity
ND440_RS06190	COG2431	L-lysine efflux transmembrane transporter activity
ND440_RS06195	COG3593	DNA synthesis involved in DNA repair
ND440_RS06200	COG2990	Protein conserved in bacteria
ND440_RS06205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_RS06215	COG1278	Cold shock
ND440_RS06220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND440_RS06225	COG0542	response to heat
ND440_RS06230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND440_RS06240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND440_RS06250	COG0492	ferredoxin-NADP+ reductase activity
ND440_RS06255	COG1522	sequence-specific DNA binding
ND440_RS06260	COG3107	peptidoglycan biosynthetic process
ND440_RS06260	COG1674	ftsk spoiiie
ND440_RS06265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND440_RS06270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND440_RS06275	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND440_RS06280	COG2814	Major facilitator Superfamily
ND440_RS06285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND440_RS06290	COG1882	Formate acetyltransferase
ND440_RS06295	COG2116	formate transmembrane transporter activity
ND440_RS06300	COG1944	ATP diphosphatase activity
ND440_RS06305	COG0252	asparaginase activity
ND440_RS06315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND440_RS06325	COG0539	negative regulation of cytoplasmic translation
ND440_RS06335	COG0658	competence protein
ND440_RS06335	COG2333	competence protein COMEC
ND440_RS06345	COG1663	tetraacyldisaccharide 4'-kinase activity
ND440_RS06350	COG5383	Protein conserved in bacteria
ND440_RS06360	COG1278	Cold shock
ND440_RS06365	COG2835	tetraacyldisaccharide 4'-kinase activity
ND440_RS06370	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND440_RS06375	COG3173	Aminoglycoside phosphotransferase
ND440_RS06380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND440_RS06385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND440_RS06390	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND440_RS06400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND440_RS06405	COG2989	Protein conserved in bacteria
ND440_RS06410	COG3108	Peptidase M15
ND440_RS06415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND440_RS06420	COG1448	Aminotransferase
ND440_RS06435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND440_RS06440	COG0308	aminopeptidase N
ND440_RS06445	COG0167	dihydroorotate dehydrogenase activity
ND440_RS06455	COG3217	Mosc domain protein beta barrel domain protein
ND440_RS06455	COG0633	Ferredoxin
ND440_RS06460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND440_RS06460	COG0116	Belongs to the methyltransferase superfamily
ND440_RS06465	COG0488	(ABC) transporter
ND440_RS06470	COG2995	paraquat-inducible protein a
ND440_RS06475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND440_RS06475	COG3008	intermembrane lipid transfer
ND440_RS06480	COG3009	Protein conserved in bacteria
ND440_RS06485	COG3130	regulation of translation
ND440_RS06490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND440_RS06495	COG1067	ATP-dependent peptidase activity
ND440_RS06500	COG3120	sequence-specific DNA binding
ND440_RS06510	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND440_RS06515	COG3070	regulator of competence-specific genes
ND440_RS06520	COG1289	transmembrane transporter activity
ND440_RS06525	COG3304	Inner membrane component domain
ND440_RS06530	COG0210	DNA helicase
ND440_RS06535	COG1803	Methylglyoxal synthase
ND440_RS06545	COG1832	CoA-binding protein
ND440_RS06550	COG3785	DNA binding
ND440_RS06555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND440_RS06560	COG1254	Belongs to the acylphosphatase family
ND440_RS06565	COG2920	part of a sulfur-relay system
ND440_RS06575	COG0288	reversible hydration of carbon dioxide
ND440_RS06595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND440_RS06600	COG2943	transferase activity, transferring hexosyl groups
ND440_RS06620	COG1560	Kdo2-lipid A biosynthetic process
ND440_RS06630	COG0628	permease
ND440_RS06655	COG0418	dihydroorotase activity
ND440_RS06660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND440_RS06670	COG1530	ribonuclease E activity
ND440_RS06675	COG0564	pseudouridine synthase activity
ND440_RS06680	COG0424	maF-like protein
ND440_RS06685	COG1399	metal-binding, possibly nucleic acid-binding protein
ND440_RS06690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND440_RS06700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND440_RS06705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND440_RS06715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND440_RS06720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND440_RS06725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND440_RS06730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND440_RS06735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND440_RS06740	COG0470	DNA polymerase III
ND440_RS06745	COG0084	hydrolase, TatD family'
ND440_RS06750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_RS06750	COG1263	PTS System
ND440_RS06755	COG0537	adenosine 5'-monophosphoramidase activity
ND440_RS06760	COG5633	Lipoprotein
ND440_RS06765	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND440_RS06780	COG3150	esterase
ND440_RS06785	COG1252	NADH dehydrogenase
ND440_RS06790	COG3134	Outer membrane lipoprotein
ND440_RS06795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND440_RS06800	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND440_RS06810	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND440_RS06830	COG2850	peptidyl-arginine hydroxylation
ND440_RS06835	COG2205	protein histidine kinase activity
ND440_RS06840	COG0745	RESPONSE REGULATOR receiver
ND440_RS06850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND440_RS06860	COG0482	sulfurtransferase activity
ND440_RS06870	COG1187	pseudouridine synthase activity
ND440_RS06875	COG0538	isocitrate dehydrogenase activity
ND440_RS06880	COG2771	luxR family
ND440_RS06885	COG3916	Acyl-homoserine-lactone synthase
ND440_RS06890	COG2723	6-phospho-beta-galactosidase activity
ND440_RS06900	COG0339	signal peptide processing
ND440_RS06905	COG0840	transmembrane signaling receptor activity
ND440_RS06910	COG3493	citrate carrier protein
ND440_RS06915	COG4565	transcriptional regulatory protein
ND440_RS06920	COG3290	protein histidine kinase activity
ND440_RS06925	COG0471	metal ion transport
ND440_RS06965	COG4977	sequence-specific DNA binding
ND440_RS06970	COG1702	phosphate starvation-inducible protein PhoH
ND440_RS06975	COG0387	Pfam Sodium calcium exchanger
ND440_RS06980	COG2375	cellular response to nickel ion
ND440_RS06985	COG3850	Histidine kinase
ND440_RS06995	COG1294	oxidase, subunit
ND440_RS07000	COG1271	oxidase subunit
ND440_RS07005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND440_RS07010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND440_RS07015	COG3138	arginine N-succinyltransferase
ND440_RS07025	COG3724	N-succinylarginine dihydrolase activity
ND440_RS07045	COG1228	amidohydrolase
ND440_RS07055	COG0402	S-adenosylhomocysteine deaminase activity
ND440_RS07075	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND440_RS07080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND440_RS07085	COG3383	formate dehydrogenase (NAD+) activity
ND440_RS07090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_RS07095	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND440_RS07105	COG3260	NADH ubiquinone oxidoreductase 20
ND440_RS07110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_RS07115	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND440_RS07115	COG3261	NADH dehydrogenase
ND440_RS07120	COG0650	Formate hydrogenlyase subunit 4
ND440_RS07125	COG0651	ATP synthesis coupled electron transport
ND440_RS07130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_RS07140	COG0375	protein maturation
ND440_RS07145	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND440_RS07150	COG0298	carbon dioxide binding
ND440_RS07155	COG0409	Hydrogenase expression formation protein
ND440_RS07160	COG0309	Hydrogenase expression formation protein (HypE)
ND440_RS07195	COG3708	Transcriptional regulator
ND440_RS07195	COG2207	Transcriptional regulator
ND440_RS07200	COG0012	GTP binding
ND440_RS07210	COG0193	aminoacyl-tRNA hydrolase activity
ND440_RS07220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND440_RS07230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND440_RS07235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND440_RS07240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND440_RS07245	COG2890	protein-(glutamine-N5) methyltransferase activity
ND440_RS07260	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND440_RS07265	COG0659	secondary active sulfate transmembrane transporter activity
ND440_RS07270	COG3706	GGDEF domain
ND440_RS07295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND440_RS07305	COG3381	protein complex oligomerization
ND440_RS07325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_RS07335	COG0673	inositol 2-dehydrogenase activity
ND440_RS07340	COG0728	peptidoglycan biosynthetic process
ND440_RS07365	COG3102	Protein conserved in bacteria
ND440_RS07370	COG3142	Participates in the control of copper homeostasis
ND440_RS07385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND440_RS07390	COG1801	Protein of unknown function DUF72
ND440_RS07400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND440_RS07405	COG0494	nUDIX hydrolase
ND440_RS07415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND440_RS07425	COG2255	four-way junction helicase activity
ND440_RS07430	COG3104	oligopeptide transport
ND440_RS07435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND440_RS07440	COG1121	(ABC) transporter
ND440_RS07445	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND440_RS07450	COG0739	heme binding
ND440_RS07455	COG1560	Kdo2-lipid A biosynthetic process
ND440_RS07460	COG0469	pyruvate kinase activity
ND440_RS07465	COG1737	Transcriptional regulator
ND440_RS07470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND440_RS07475	COG0800	Aldolase
ND440_RS07485	COG2076	Multidrug Resistance protein
ND440_RS07490	COG0251	oxidation-reduction process
ND440_RS07495	COG1199	ATP-dependent helicase activity
ND440_RS07500	COG1214	PFAM Peptidase M22, glycoprotease
ND440_RS07505	COG3065	identical protein binding
ND440_RS07510	COG0318	PFAM AMP-dependent synthetase and ligase
ND440_RS07515	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND440_RS07520	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND440_RS07525	COG2894	cell division
ND440_RS07530	COG0850	regulation of cytokinetic process
ND440_RS07535	COG3100	YcgL domain-containing protein
ND440_RS07540	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND440_RS07545	COG2983	Belongs to the UPF0260 family
ND440_RS07565	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND440_RS07575	COG2719	SpoVR family
ND440_RS07580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND440_RS07585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND440_RS07590	COG2814	Major facilitator Superfamily
ND440_RS07600	COG2202	Pas domain
ND440_RS07600	COG2200	EAL domain
ND440_RS07600	COG2199	diguanylate cyclase activity
ND440_RS07620	COG2718	Belongs to the UPF0229 family
ND440_RS07625	COG2766	serine protein kinase
ND440_RS07635	COG3713	MltA-interacting MipA family protein
ND440_RS07640	COG2194	sulfuric ester hydrolase activity
ND440_RS07655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND440_RS07660	COG3139	Protein of unknown function (DUF1315)
ND440_RS07665	COG1335	isochorismatase
ND440_RS07670	COG0252	asparaginase activity
ND440_RS07675	COG0616	signal peptide processing
ND440_RS07680	COG0778	Nitroreductase
ND440_RS07690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND440_RS07700	COG0494	nUDIX hydrolase
ND440_RS07705	COG0708	Exodeoxyribonuclease III
ND440_RS07740	COG0788	formyltetrahydrofolate deformylase activity
ND440_RS07750	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND440_RS07755	COG0745	RESPONSE REGULATOR receiver
ND440_RS07775	COG1454	alcohol dehydrogenase
ND440_RS07775	COG1012	belongs to the aldehyde dehydrogenase family
ND440_RS07785	COG2095	MarC family integral membrane protein
ND440_RS07790	COG4166	transmembrane transport
ND440_RS07805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND440_RS07820	COG3099	Belongs to the UPF0263 family
ND440_RS07825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND440_RS07850	COG2350	Protein conserved in bacteria
ND440_RS07865	COG3710	Transcriptional regulator
ND440_RS07900	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND440_RS07925	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND440_RS07930	COG3047	cAMP biosynthetic process
ND440_RS07945	COG0133	tryptophan synthase activity
ND440_RS07950	COG0135	phosphoribosylanthranilate isomerase activity
ND440_RS07950	COG0134	indole-3-glycerol-phosphate synthase activity
ND440_RS07960	COG0512	Glutamine amidotransferase of anthranilate synthase
ND440_RS07970	COG0613	PHP domain protein
ND440_RS07975	COG0009	L-threonylcarbamoyladenylate synthase
ND440_RS07980	COG1187	pseudouridine synthase activity
ND440_RS07990	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_RS07995	COG0616	signal peptide processing
ND440_RS08010	COG0583	DNA-binding transcription factor activity
ND440_RS08035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND440_RS08045	COG0671	phosphoesterase, PA-phosphatase related
ND440_RS08050	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND440_RS08055	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND440_RS08075	COG0023	Translation Initiation Factor
ND440_RS08085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND440_RS08090	COG5002	protein histidine kinase activity
ND440_RS08090	COG5001	Diguanylate cyclase
ND440_RS08090	COG3447	MASE1 domain protein
ND440_RS08095	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND440_RS08100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND440_RS08110	COG4659	FMN binding
ND440_RS08120	COG2207	Transcriptional regulator
ND440_RS08120	COG3708	Transcriptional regulator
ND440_RS08135	COG4657	Part of a membrane complex involved in electron transport
ND440_RS08145	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND440_RS08155	COG0673	inositol 2-dehydrogenase activity
ND440_RS08160	COG0385	Bile acid
ND440_RS08165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND440_RS08170	COG5339	Protein conserved in bacteria
ND440_RS08175	COG1482	cell wall glycoprotein biosynthetic process
ND440_RS08180	COG0114	fumarate hydratase activity
ND440_RS08190	COG1940	carbohydrate kinase activity
ND440_RS08195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND440_RS08215	COG1742	UPF0060 membrane protein
ND440_RS08220	COG4221	oxidoreductase activity
ND440_RS08225	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND440_RS08245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND440_RS08285	COG1011	Hydrolase
ND440_RS08295	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND440_RS08300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND440_RS08305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND440_RS08310	COG0589	response to stress
ND440_RS08340	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND440_RS08345	COG3623	hexulose-6-phosphate isomerase
ND440_RS08350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND440_RS08355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND440_RS08365	COG0531	amino acid
ND440_RS08375	COG0745	RESPONSE REGULATOR receiver
ND440_RS08380	COG2205	protein histidine kinase activity
ND440_RS08395	COG2207	Transcriptional regulator
ND440_RS08400	COG1881	PFAM PEBP family protein
ND440_RS08410	COG3591	Belongs to the peptidase S1B family
ND440_RS08415	COG1643	Atp-dependent helicase
ND440_RS08420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND440_RS08425	COG3784	Protein of unknown function (DUF1318)
ND440_RS08440	COG2911	Protein conserved in bacteria
ND440_RS08445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND440_RS08450	COG3187	Heat shock protein
ND440_RS08455	COG3042	response to heat
ND440_RS08460	COG1285	pathogenesis
ND440_RS08470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_RS08470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND440_RS08470	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND440_RS08470	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND440_RS08485	COG4166	transmembrane transport
ND440_RS08490	COG2866	Carboxypeptidase
ND440_RS08495	COG4948	Mandelate Racemase Muconate Lactonizing
ND440_RS08500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND440_RS08510	COG5642	Protein of unknown function (DUF2384)
ND440_RS08515	COG5654	RES domain protein
ND440_RS08520	COG3768	UPF0283 membrane protein
ND440_RS08525	COG3106	COG3106 Predicted ATPase
ND440_RS08535	COG1983	PspC domain protein
ND440_RS08545	COG1842	Phage shock protein A
ND440_RS08550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND440_RS08565	COG4166	transmembrane transport
ND440_RS08575	COG4171	peptide transport system, permease
ND440_RS08580	COG4172	Belongs to the ABC transporter superfamily
ND440_RS08585	COG4172	Belongs to the ABC transporter superfamily
ND440_RS08595	COG3104	oligopeptide transport
ND440_RS08605	COG0484	heat shock protein binding
ND440_RS08650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND440_RS08655	COG3133	Outer membrane lipoprotein
ND440_RS08660	COG1846	Transcriptional regulator
ND440_RS08670	COG4989	oxidoreductase activity
ND440_RS08675	COG3313	Fe-S protein
ND440_RS08680	COG2194	sulfuric ester hydrolase activity
ND440_RS08685	COG1309	transcriptional regulator
ND440_RS08690	COG1902	pentaerythritol trinitrate reductase activity
ND440_RS08705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND440_RS08710	COG0791	NLP P60 protein
ND440_RS08715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND440_RS08725	COG1609	Transcriptional regulator
ND440_RS08730	COG0583	DNA-binding transcription factor activity
ND440_RS08735	COG2814	Major facilitator Superfamily
ND440_RS08740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND440_RS08745	COG0307	riboflavin synthase, alpha
ND440_RS08780	COG1388	LysM domain
ND440_RS08780	COG1376	ErfK ybiS ycfS ynhG family protein
ND440_RS08785	COG2166	iron-sulfur cluster assembly
ND440_RS08795	COG0719	Fe-S assembly protein
ND440_RS08800	COG0396	ATPase activity
ND440_RS08805	COG0719	Fe-S assembly protein
ND440_RS08810	COG0316	Belongs to the HesB IscA family
ND440_RS08815	COG2050	protein possibly involved in aromatic compounds catabolism
ND440_RS08820	COG0247	lactate metabolic process
ND440_RS08820	COG0277	FAD linked oxidase domain protein
ND440_RS08825	COG0628	permease
ND440_RS08835	COG0574	Belongs to the PEP-utilizing enzyme family
ND440_RS08835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND440_RS08840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND440_RS08845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND440_RS08855	COG4771	TonB-dependent receptor
ND440_RS08860	COG3720	iron ion transport
ND440_RS08865	COG4558	Periplasmic binding protein
ND440_RS08870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_RS08875	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND440_RS08885	COG0095	Lipoate-protein ligase
ND440_RS08890	COG0791	NLP P60 protein
ND440_RS08895	COG2076	Multidrug Resistance protein
ND440_RS08900	COG2076	Multidrug Resistance protein
ND440_RS08905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND440_RS08920	COG0463	Glycosyl transferase, family 2
ND440_RS08925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND440_RS08935	COG4139	cobalamin transport
ND440_RS09005	COG0776	regulation of translation
ND440_RS09075	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND440_RS09080	COG1121	(ABC) transporter
ND440_RS09085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND440_RS09090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND440_RS09095	COG3001	Fructosamine kinase
ND440_RS09105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND440_RS09110	COG1988	membrane-bound metal-dependent
ND440_RS09115	COG1823	symporter activity
ND440_RS09120	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND440_RS09130	COG2814	Major facilitator Superfamily
ND440_RS09140	COG0501	Belongs to the peptidase M48B family
ND440_RS09145	COG0793	Belongs to the peptidase S41A family
ND440_RS09155	COG1956	GAF domain-containing protein
ND440_RS09160	COG2995	paraquat-inducible protein a
ND440_RS09165	COG3008	intermembrane lipid transfer
ND440_RS09170	COG2203	Gaf domain
ND440_RS09170	COG5001	Diguanylate cyclase
ND440_RS09170	COG4251	negative regulation of phosphorylation
ND440_RS09170	COG3706	GGDEF domain
ND440_RS09250	COG1276	copper resistance
ND440_RS09255	COG2372	response to copper ion
ND440_RS09260	COG1528	Iron-storage protein
ND440_RS09275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND440_RS09280	COG1770	oligopeptidase
ND440_RS09290	COG3097	Belongs to the UPF0267 family
ND440_RS09295	COG3141	response to X-ray
ND440_RS09300	COG0513	Belongs to the DEAD box helicase family
ND440_RS09320	COG0494	nUDIX hydrolase
ND440_RS09325	COG1760	l-serine dehydratase
ND440_RS09330	COG1253	flavin adenine dinucleotide binding
ND440_RS09335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_RS09335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_RS09340	COG3715	PTS system
ND440_RS09345	COG3716	PTS system mannose fructose sorbose family IID component
ND440_RS09350	COG4811	Protein of unknown function (DUF986)
ND440_RS09355	COG1971	Probably functions as a manganese efflux pump
ND440_RS09375	COG1960	acyl-CoA dehydrogenase activity
ND440_RS09385	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND440_RS09415	COG2226	methyltransferase
ND440_RS09420	COG0768	penicillin binding
ND440_RS09425	COG1496	oxidoreductase activity
ND440_RS09445	COG1113	amino acid transport
ND440_RS09480	COG2207	Transcriptional regulator
ND440_RS09500	COG1132	(ABC) transporter
ND440_RS09510	COG5001	Diguanylate cyclase
ND440_RS09510	COG3706	GGDEF domain
ND440_RS09510	COG2203	Gaf domain
ND440_RS09510	COG4251	negative regulation of phosphorylation
ND440_RS09530	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND440_RS09550	COG1278	Cold shock
ND440_RS09555	COG1278	Cold shock
ND440_RS09560	COG1278	Cold shock
ND440_RS09575	COG2169	Transcriptional regulator
ND440_RS09575	COG1917	Cupin 2, conserved barrel domain protein
ND440_RS09580	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND440_RS09585	COG2723	6-phospho-beta-galactosidase activity
ND440_RS09590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND440_RS09595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND440_RS09600	COG1187	pseudouridine synthase activity
ND440_RS09610	COG3122	Protein conserved in bacteria
ND440_RS09615	COG1757	Na H antiporter
ND440_RS09645	COG0076	glutamate decarboxylase activity
ND440_RS09650	COG0531	amino acid
ND440_RS09685	COG2153	protein acetylation
ND440_RS09690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND440_RS09720	COG0840	transmembrane signaling receptor activity
ND440_RS09725	COG2801	Transposase and inactivated derivatives
ND440_RS09850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND440_RS09855	COG0322	excinuclease ABC activity
ND440_RS09860	COG2197	response regulator
ND440_RS09885	COG1113	amino acid transport
ND440_RS09895	COG0531	amino acid
ND440_RS09900	COG3710	Transcriptional regulator
ND440_RS09905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND440_RS09910	COG0506	proline dehydrogenase activity
ND440_RS09910	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND440_RS09910	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND440_RS09915	COG1126	abc transporter atp-binding protein
ND440_RS09920	COG0765	amino acid transport
ND440_RS09925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_RS09930	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND440_RS09940	COG1191	sigma factor activity
ND440_RS09980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND440_RS09985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND440_RS10000	COG1677	Flagellar hook-basal body complex protein FliE
ND440_RS10010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND440_RS10020	COG1157	protein secretion by the type III secretion system
ND440_RS10035	COG1580	Controls the rotational direction of flagella during chemotaxis
ND440_RS10115	COG1558	bacterial-type flagellum-dependent cell motility
ND440_RS10120	COG1815	bacterial-type flagellum-dependent cell motility
ND440_RS10130	COG2747	anti-sigma28 factor FlgM
ND440_RS10135	COG3418	PFAM FlgN family protein
ND440_RS10145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND440_RS10150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND440_RS10155	COG1404	Belongs to the peptidase S8 family
ND440_RS10155	COG4935	Belongs to the peptidase S8 family
ND440_RS10160	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND440_RS10165	COG0745	RESPONSE REGULATOR receiver
ND440_RS10175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND440_RS10180	COG0840	transmembrane signaling receptor activity
ND440_RS10185	COG0840	transmembrane signaling receptor activity
ND440_RS10190	COG0835	chemotaxis
ND440_RS10195	COG2198	Histidine kinase
ND440_RS10195	COG0643	Histidine kinase
ND440_RS10200	COG1360	Flagellar Motor Protein
ND440_RS10220	COG0589	response to stress
ND440_RS10225	COG1285	pathogenesis
ND440_RS10230	COG0840	transmembrane signaling receptor activity
ND440_RS10245	COG1609	Transcriptional regulator
ND440_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_RS10255	COG3321	synthase
ND440_RS10255	COG0604	alcohol dehydrogenase
ND440_RS10310	COG0471	metal ion transport
ND440_RS10325	COG3051	citrate lyase alpha subunit
ND440_RS10330	COG2301	Belongs to the HpcH HpaI aldolase family
ND440_RS10335	COG3052	prosthetic group binding
ND440_RS10340	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND440_RS10345	COG3290	protein histidine kinase activity
ND440_RS10350	COG4565	transcriptional regulatory protein
ND440_RS10365	COG2271	Major facilitator Superfamily
ND440_RS10370	COG1840	ABC-type Fe3 transport system, periplasmic component
ND440_RS10380	COG3842	ATPase activity
ND440_RS10400	COG1289	transmembrane transporter activity
ND440_RS10410	COG2925	Exonuclease
ND440_RS10415	COG0531	amino acid
ND440_RS10420	COG4771	TonB-dependent receptor
ND440_RS10430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND440_RS10440	COG0833	amino acid
ND440_RS10445	COG0583	DNA-binding transcription factor activity
ND440_RS10455	COG2855	membrane
ND440_RS10460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND440_RS10465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND440_RS10465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND440_RS10465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND440_RS10470	COG1105	Belongs to the carbohydrate kinase PfkB family
ND440_RS10485	COG3005	denitrification pathway
ND440_RS10490	COG0243	molybdopterin cofactor binding
ND440_RS10505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND440_RS10515	COG0246	Mannitol dehydrogenase
ND440_RS10525	COG0523	cobalamin synthesis protein
ND440_RS10530	COG0671	phosphoesterase, PA-phosphatase related
ND440_RS10535	COG0791	NLP P60 protein
ND440_RS10540	COG2200	EAL domain
ND440_RS10545	COG4166	transmembrane transport
ND440_RS10550	COG4174	ABC transporter (Permease)
ND440_RS10555	COG4239	(ABC) transporter, permease
ND440_RS10560	COG4172	Belongs to the ABC transporter superfamily
ND440_RS10570	COG2814	Major facilitator Superfamily
ND440_RS10575	COG1187	pseudouridine synthase activity
ND440_RS10580	COG1061	Type III restriction enzyme res subunit
ND440_RS10595	COG3082	Protein of unknown function (DUF1414)
ND440_RS10600	COG3083	sulfuric ester hydrolase activity
ND440_RS10625	COG3778	Protein conserved in bacteria
ND440_RS10630	COG3299	homolog of phage Mu protein gp47
ND440_RS10675	COG4386	tail sheath protein
ND440_RS10725	COG1802	Transcriptional regulator
ND440_RS10725	COG4626	Terminase
ND440_RS10750	COG1876	peptidase activity
ND440_RS10780	COG0515	serine threonine protein kinase
ND440_RS10780	COG2815	serine threonine protein kinase
ND440_RS10795	COG1403	HNH endonuclease
ND440_RS10810	COG4725	Belongs to the MT-A70-like family
ND440_RS10815	COG1802	Transcriptional regulator
ND440_RS10815	COG4626	Terminase
ND440_RS10850	COG5532	Uncharacterized conserved protein (DUF2303)
ND440_RS10855	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND440_RS10905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND440_RS10910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_RS10930	COG2223	nitrite transmembrane transporter activity
ND440_RS10935	COG2198	Histidine kinase
ND440_RS10935	COG0642	Histidine kinase
ND440_RS10945	COG0784	Response regulator, receiver
ND440_RS10945	COG2205	protein histidine kinase activity
ND440_RS10955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND440_RS10960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND440_RS10970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND440_RS10980	COG4574	serine-type endopeptidase inhibitor activity
ND440_RS10990	COG2246	polysaccharide biosynthetic process
ND440_RS11005	COG0814	amino acid
ND440_RS11030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND440_RS11035	COG0596	Alpha beta hydrolase
ND440_RS11040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND440_RS11045	COG1169	isochorismate synthase
ND440_RS11050	COG4575	ribosome binding
ND440_RS11065	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_RS11070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND440_RS11080	COG0839	Belongs to the complex I subunit 6 family
ND440_RS11085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_RS11090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND440_RS11095	COG1034	ATP synthesis coupled electron transport
ND440_RS11115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_RS11120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND440_RS11125	COG0583	DNA-binding transcription factor activity
ND440_RS11130	COG0436	Aminotransferase
ND440_RS11135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND440_RS11140	COG0490	domain, Protein
ND440_RS11140	COG0471	metal ion transport
ND440_RS11150	COG3013	Belongs to the UPF0304 family
ND440_RS11155	COG3092	negative regulation of chromosome organization
ND440_RS11165	COG0280	phosphate acetyltransferase
ND440_RS11165	COG0857	belongs to the CobB CobQ family
ND440_RS11170	COG1609	Transcriptional regulator
ND440_RS11185	COG3037	sugar-specific permease SgaT UlaA
ND440_RS11190	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND440_RS11195	COG0622	Phosphoesterase
ND440_RS11205	COG0625	glutathione transferase activity
ND440_RS11210	COG1090	epimerase
ND440_RS11220	COG4160	amino acid transport
ND440_RS11225	COG4215	(ABC) transporter
ND440_RS11240	COG0163	prenyltransferase activity
ND440_RS11245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND440_RS11250	COG1286	toxin biosynthetic process
ND440_RS11255	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND440_RS11260	COG0285	dihydrofolate synthase activity
ND440_RS11270	COG0586	Pfam SNARE associated Golgi protein
ND440_RS11280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND440_RS11305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND440_RS11310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND440_RS11340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND440_RS11355	COG3101	peptidyl-lysine hydroxylation
ND440_RS11360	COG0730	response to heat
ND440_RS11365	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND440_RS11375	COG2890	protein-(glutamine-N5) methyltransferase activity
ND440_RS11380	COG2840	Smr protein MutS2
ND440_RS11385	COG2062	phosphohistidine phosphatase, SixA
ND440_RS11390	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND440_RS11390	COG1024	Enoyl-CoA hydratase
ND440_RS11395	COG0183	Belongs to the thiolase family
ND440_RS11400	COG3691	Protein conserved in bacteria
ND440_RS11415	COG3088	subunit of a heme lyase
ND440_RS11415	COG4235	cytochrome complex assembly
ND440_RS11420	COG4235	cytochrome complex assembly
ND440_RS11420	COG3088	subunit of a heme lyase
ND440_RS11425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND440_RS11430	COG1138	Cytochrome C-type biogenesis protein
ND440_RS11435	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND440_RS11440	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND440_RS11445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND440_RS11450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND440_RS11470	COG2824	Alkylphosphonate utilization operon protein PhnA
ND440_RS11475	COG2951	lytic endotransglycosylase activity
ND440_RS11490	COG3038	cytochrome b561
ND440_RS11515	COG3275	phosphorelay sensor kinase activity
ND440_RS11520	COG3279	Response regulator of the LytR AlgR family
ND440_RS11525	COG2223	nitrite transmembrane transporter activity
ND440_RS11530	COG0837	glucose binding
ND440_RS11550	COG1914	H( )-stimulated, divalent metal cation uptake system
ND440_RS11555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND440_RS11625	COG3530	Putative quorum-sensing-regulated virulence factor
ND440_RS11630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND440_RS11640	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND440_RS11650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_RS11665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND440_RS11675	COG4208	sulfate ABC transporter
ND440_RS11680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND440_RS11685	COG4150	thiosulfate binding
ND440_RS11695	COG1737	Transcriptional regulator
ND440_RS11700	COG2731	YhcH YjgK YiaL family protein
ND440_RS11715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND440_RS11720	COG2837	iron assimilation
ND440_RS11730	COG3111	PFAM Bacterial OB fold (BOF) protein
ND440_RS11825	COG1671	Belongs to the UPF0178 family
ND440_RS11830	COG0281	malic enzyme
ND440_RS11830	COG0280	phosphate acetyltransferase
ND440_RS11840	COG3005	denitrification pathway
ND440_RS11845	COG3043	anaerobic respiration
ND440_RS11850	COG0243	molybdopterin cofactor binding
ND440_RS11855	COG3062	negative regulation of establishment of protein localization
ND440_RS11860	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_RS11860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_RS11865	COG2197	response regulator
ND440_RS11875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_RS11885	COG1605	Chorismate mutase
ND440_RS11890	COG1393	Belongs to the ArsC family
ND440_RS11895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND440_RS11900	COG1876	peptidase activity
ND440_RS11910	COG0400	carboxylic ester hydrolase activity
ND440_RS11930	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND440_RS11935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND440_RS11940	COG2716	regulation of RNA biosynthetic process
ND440_RS11945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND440_RS11950	COG0628	permease
ND440_RS11955	COG4783	chaperone-mediated protein folding
ND440_RS11960	COG1393	Belongs to the ArsC family
ND440_RS11965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND440_RS11970	COG2233	PERMEase
ND440_RS11975	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND440_RS11980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND440_RS11985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND440_RS11990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_RS12000	COG0581	inorganic phosphate transmembrane transporter activity
ND440_RS12005	COG0573	inorganic phosphate transmembrane transporter activity
ND440_RS12010	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND440_RS12025	COG2239	Acts as a magnesium transporter
ND440_RS12030	COG0443	Heat shock 70 kDa protein
ND440_RS12040	COG3121	Chaperone
ND440_RS12055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_RS12065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_RS12070	COG0477	Major facilitator Superfamily
ND440_RS12075	COG2205	protein histidine kinase activity
ND440_RS12080	COG0745	RESPONSE REGULATOR receiver
ND440_RS12085	COG3422	double-strand break repair
ND440_RS12090	COG0826	peptidase U32
ND440_RS12095	COG1597	lipid kinase activity
ND440_RS12110	COG0351	phosphomethylpyrimidine kinase
ND440_RS12120	COG0519	Catalyzes the synthesis of GMP from XMP
ND440_RS12120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND440_RS12125	COG0517	IMP dehydrogenase activity
ND440_RS12125	COG0516	GMP reductase activity
ND440_RS12130	COG1570	exodeoxyribonuclease VII activity
ND440_RS12135	COG1645	bacterial-type flagellum-dependent swarming motility
ND440_RS12145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND440_RS12150	COG2976	Protein conserved in bacteria
ND440_RS12155	COG0124	histidyl-tRNA synthetase
ND440_RS12175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND440_RS12190	COG4953	penicillin-binding protein 1C
ND440_RS12195	COG2373	Large extracellular alpha-helical protein
ND440_RS12210	COG2975	iron-sulfur cluster assembly
ND440_RS12215	COG0633	Ferredoxin
ND440_RS12220	COG0443	Heat shock 70 kDa protein
ND440_RS12235	COG0822	iron-sulfur transferase activity
ND440_RS12245	COG1959	2 iron, 2 sulfur cluster binding
ND440_RS12250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND440_RS12260	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND440_RS12265	COG3683	transport system, periplasmic component
ND440_RS12270	COG3711	transcriptional antiterminator
ND440_RS12275	COG2814	Major facilitator Superfamily
ND440_RS12285	COG1017	nitric oxide dioxygenase activity
ND440_RS12285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND440_RS12290	COG2188	Transcriptional regulator
ND440_RS12300	COG3457	Alanine racemase
ND440_RS12305	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND440_RS12320	COG0347	Belongs to the P(II) protein family
ND440_RS12325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND440_RS12325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_RS12330	COG2204	response regulator
ND440_RS12335	COG3170	Tfp pilus assembly protein FimV
ND440_RS12340	COG2205	protein histidine kinase activity
ND440_RS12355	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND440_RS12365	COG0560	Phosphoserine phosphatase
ND440_RS12370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_RS12370	COG1263	PTS System
ND440_RS12380	COG1737	Transcriptional regulator
ND440_RS12385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND440_RS12395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND440_RS12405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND440_RS12420	COG0481	GTPase activity
ND440_RS12425	COG3086	response to oxidative stress
ND440_RS12435	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND440_RS12445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND440_RS12455	COG0513	Belongs to the DEAD box helicase family
ND440_RS12470	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND440_RS12480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND440_RS12485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND440_RS12490	COG0497	DNA recombination
ND440_RS12495	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND440_RS12505	COG2867	negative regulation of translational initiation
ND440_RS12510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND440_RS12520	COG0582	viral genome integration into host DNA
ND440_RS12545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND440_RS12555	COG1122	ATPase activity
ND440_RS12610	COG1069	ribulokinase activity
ND440_RS12620	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND440_RS12625	COG1129	ABC transporter
ND440_RS12645	COG1620	l-lactate permease
ND440_RS12650	COG1304	FMN binding
ND440_RS12655	COG0579	oxidoreductase
ND440_RS12660	COG1278	Cold shock
ND440_RS12690	COG1780	Probably involved in ribonucleotide reductase function
ND440_RS12695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND440_RS12705	COG4175	Glycine betaine
ND440_RS12710	COG4176	ABC-type proline glycine betaine transport system permease component
ND440_RS12715	COG2113	Glycine betaine
ND440_RS12720	COG2814	Major facilitator Superfamily
ND440_RS12725	COG1846	Transcriptional regulator
ND440_RS12735	COG1566	PFAM secretion protein HlyD family protein
ND440_RS12740	COG2814	Major facilitator Superfamily
ND440_RS12745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND440_RS12750	COG3118	belongs to the thioredoxin family
ND440_RS12755	COG3148	PFAM DTW domain containing protein
ND440_RS12760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND440_RS12760	COG1042	CoA-binding domain protein
ND440_RS12760	COG0045	succinate-CoA ligase (ADP-forming) activity
ND440_RS12765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND440_RS12770	COG5544	Lipoprotein
ND440_RS12800	COG0542	response to heat
ND440_RS12805	COG1496	oxidoreductase activity
ND440_RS12810	COG0564	pseudouridine synthase activity
ND440_RS12815	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND440_RS12820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND440_RS12830	COG0077	Prephenate dehydratase
ND440_RS12830	COG1605	Chorismate mutase
ND440_RS12835	COG0287	Prephenate dehydrogenase
ND440_RS12835	COG1605	Chorismate mutase
ND440_RS12840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND440_RS12845	COG3279	Response regulator of the LytR AlgR family
ND440_RS12850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND440_RS12855	COG3137	Salt-induced outer membrane protein
ND440_RS12860	COG0335	large ribosomal subunit rRNA binding
ND440_RS12865	COG0336	Belongs to the RNA methyltransferase TrmD family
ND440_RS12870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND440_RS12880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND440_RS12885	COG4137	Cytochrome C assembly protein
ND440_RS12890	COG4536	flavin adenine dinucleotide binding
ND440_RS12895	COG1854	S-ribosylhomocysteine lyase activity
ND440_RS12900	COG2918	glutathione biosynthetic process
ND440_RS12905	COG1238	metal cluster binding
ND440_RS12910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND440_RS12940	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND440_RS12945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND440_RS12950	COG2137	regulation of response to DNA damage stimulus
ND440_RS12955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND440_RS12970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND440_RS12970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND440_RS12995	COG3031	protein transport across the cell outer membrane
ND440_RS13005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND440_RS13050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND440_RS13060	COG3397	chitin binding
ND440_RS13080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND440_RS13230	COG0784	Response regulator, receiver
ND440_RS13230	COG2205	protein histidine kinase activity
ND440_RS13305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND440_RS13310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND440_RS13315	COG1388	LysM domain
ND440_RS13315	COG4942	peptidase
ND440_RS13325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND440_RS13330	COG0585	pseudouridine synthase activity
ND440_RS13335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND440_RS13345	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND440_RS13355	COG0529	Catalyzes the synthesis of activated sulfate
ND440_RS13360	COG2895	sulfate adenylyltransferase (ATP) activity
ND440_RS13365	COG0175	sulfate reduction
ND440_RS13370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND440_RS13370	COG1648	precorrin-2 dehydrogenase activity
ND440_RS13375	COG2234	aminopeptidase activity
ND440_RS13390	COG0175	sulfate reduction
ND440_RS13400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND440_RS13405	COG0720	synthase
ND440_RS13415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ND440_RS13485	COG4386	tail sheath protein
ND440_RS13510	COG4397	Mu-like prophage major head subunit gpT
ND440_RS13535	COG4383	Mu-like prophage protein gp29
ND440_RS13590	COG4382	Mu-like prophage protein Gp16
ND440_RS13655	COG3423	Transcriptional regulator
ND440_RS13675	COG0504	CTP synthase activity
ND440_RS13680	COG3956	TIGRFAM MazG family protein
ND440_RS13685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND440_RS13690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND440_RS13700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND440_RS13705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND440_RS13710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND440_RS13720	COG2860	membrane
ND440_RS13725	COG0316	Belongs to the HesB IscA family
ND440_RS13735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND440_RS13740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND440_RS13745	COG1643	Atp-dependent helicase
ND440_RS13750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND440_RS13755	COG1489	DNA binding
ND440_RS13770	COG0617	tRNA 3'-terminal CCA addition
ND440_RS13775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND440_RS13780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND440_RS13785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND440_RS13790	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND440_RS13795	COG0726	polysaccharide deacetylase
ND440_RS13800	COG0842	Transport permease protein
ND440_RS13805	COG1131	(ABC) transporter
ND440_RS13810	COG0288	reversible hydration of carbon dioxide
ND440_RS13820	COG2132	Multicopper oxidase
ND440_RS13830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND440_RS13845	COG3112	Uncharacterised protein family (UPF0231)
ND440_RS13850	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND440_RS13860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_RS13865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND440_RS13870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND440_RS13875	COG2186	Transcriptional regulator
ND440_RS13880	COG1113	amino acid transport
ND440_RS13885	COG3725	Membrane protein required for beta-lactamase induction
ND440_RS13900	COG4969	Belongs to the N-Me-Phe pilin family
ND440_RS13905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND440_RS13910	COG1459	type II secretion system
ND440_RS13915	COG0516	GMP reductase activity
ND440_RS13935	COG0494	nUDIX hydrolase
ND440_RS13960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND440_RS13965	COG0849	cell division
ND440_RS13970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND440_RS13980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND440_RS13985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND440_RS13990	COG0772	Belongs to the SEDS family
ND440_RS14005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND440_RS14010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND440_RS14015	COG0768	penicillin binding
ND440_RS14020	COG3116	cell division
ND440_RS14025	COG0275	rRNA processing
ND440_RS14045	COG0675	Transposase, IS605 OrfB family
ND440_RS14060	COG0028	Belongs to the TPP enzyme family
ND440_RS14065	COG1022	Amp-dependent synthetase and ligase
ND440_RS14080	COG0473	3-isopropylmalate dehydrogenase activity
ND440_RS14085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND440_RS14095	COG2814	Major facilitator Superfamily
ND440_RS14110	COG4143	(ABC) transporter
ND440_RS14115	COG1178	ABC-type Fe3 transport system permease component
ND440_RS14125	COG0586	Pfam SNARE associated Golgi protein
ND440_RS14130	COG0417	DNA replication proofreading
ND440_RS14135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND440_RS14140	COG0564	pseudouridine synthase activity
ND440_RS14150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND440_RS14160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND440_RS14165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND440_RS14170	COG2967	ApaG domain
ND440_RS14195	COG2966	Psort location CytoplasmicMembrane, score
ND440_RS14205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND440_RS14220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND440_RS14225	COG1047	Peptidyl-prolyl cis-trans
ND440_RS14230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND440_RS14240	COG0196	riboflavin kinase activity
ND440_RS14250	COG0583	DNA-binding transcription factor activity
ND440_RS14255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND440_RS14265	COG0443	Heat shock 70 kDa protein
ND440_RS14270	COG1584	GPR1 FUN34 yaaH family protein
ND440_RS14280	COG0477	Major facilitator Superfamily
ND440_RS14285	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND440_RS14290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND440_RS14325	COG0745	RESPONSE REGULATOR receiver
ND440_RS14330	COG3045	CreA protein
ND440_RS14335	COG2207	Transcriptional regulator
ND440_RS14335	COG3708	Transcriptional regulator
ND440_RS14340	COG0406	alpha-ribazole phosphatase activity
ND440_RS14345	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND440_RS14350	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND440_RS14355	COG0741	lytic transglycosylase activity
ND440_RS14375	COG0488	(ABC) transporter
ND440_RS14390	COG0560	Phosphoserine phosphatase
ND440_RS14395	COG3726	membrane protein affecting hemolysin expression
ND440_RS14405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND440_RS14420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND440_RS14425	COG0084	hydrolase, TatD family'
ND440_RS14430	COG4667	esterase of the alpha-beta hydrolase superfamily
ND440_RS14440	COG2823	Periplasmic or secreted lipoprotein
ND440_RS14455	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND440_RS14495	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND440_RS14495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND440_RS14495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND440_RS14500	COG1461	Dihydroxyacetone kinase
ND440_RS14505	COG2376	Dihydroxyacetone kinase
ND440_RS14515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND440_RS14520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND440_RS14535	COG0859	PFAM glycosyl transferase family 9
ND440_RS14560	COG3119	arylsulfatase activity
ND440_RS14565	COG0641	radical SAM
ND440_RS14575	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_RS14585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND440_RS14595	COG3716	PTS system mannose fructose sorbose family IID component
ND440_RS14600	COG3715	PTS system
ND440_RS14605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND440_RS14610	COG2222	sugar isomerase
ND440_RS14620	COG1349	DNA-binding transcription factor activity
ND440_RS14625	COG3119	arylsulfatase activity
ND440_RS14645	COG5492	domain, Protein
ND440_RS14735	COG3077	Addiction module antitoxin, RelB DinJ family
ND440_RS14750	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ND440_RS14755	COG0732	type I restriction modification DNA specificity domain
ND440_RS14760	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ND440_RS14800	COG0795	lipopolysaccharide-transporting ATPase activity
ND440_RS14805	COG0795	lipopolysaccharide-transporting ATPase activity
ND440_RS14810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND440_RS14815	COG2927	DNA polymerase III (CHI subunit)
ND440_RS14830	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND440_RS14850	COG3624	Phosphonate C-P lyase system protein PhnG
ND440_RS14855	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND440_RS14860	COG3626	phosphonate metabolism
ND440_RS14865	COG3627	carbon phosphorus lyase activity
ND440_RS14870	COG4107	phosphonate C-P lyase system protein PhnK
ND440_RS14875	COG4778	phosphonate C-P lyase system protein PhnL
ND440_RS14880	COG3454	Phosphonate metabolism
ND440_RS14885	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND440_RS14890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND440_RS14895	COG0702	epimerase
ND440_RS14900	COG3787	Belongs to the UPF0306 family
ND440_RS14910	COG1982	Orn Lys Arg decarboxylase major
ND440_RS14915	COG0531	amino acid
ND440_RS14920	COG2827	Endonuclease containing a URI domain
ND440_RS14925	COG3153	acetyltransferase
ND440_RS14930	COG3154	lipid carrier protein
ND440_RS14935	COG0826	peptidase U32
ND440_RS14940	COG0826	peptidase U32
ND440_RS14950	COG0814	amino acid
ND440_RS14955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND440_RS14960	COG0513	Belongs to the DEAD box helicase family
ND440_RS14970	COG1185	polyribonucleotide nucleotidyltransferase activity
ND440_RS14985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND440_RS14995	COG0195	Participates in both transcription termination and antitermination
ND440_RS15015	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND440_RS15020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND440_RS15025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND440_RS15035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND440_RS15040	COG1534	Rna-binding protein
ND440_RS15050	COG2027	D-alanyl-D-alanine carboxypeptidase
ND440_RS15055	COG0745	RESPONSE REGULATOR receiver
ND440_RS15060	COG0642	Histidine kinase
ND440_RS15065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND440_RS15070	COG0697	spore germination
ND440_RS15085	COG0142	geranyltranstransferase activity
ND440_RS15100	COG3423	Transcriptional regulator
ND440_RS15115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND440_RS15125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND440_RS15130	COG2105	PFAM AIG2 family protein
ND440_RS15135	COG2911	Protein conserved in bacteria
ND440_RS15140	COG0729	surface antigen
ND440_RS15145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND440_RS15150	COG1253	flavin adenine dinucleotide binding
ND440_RS15160	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND440_RS15165	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND440_RS15170	COG0737	Belongs to the 5'-nucleotidase family
ND440_RS15180	COG0545	Peptidyl-prolyl cis-trans isomerase
ND440_RS15185	COG3061	Opacity-associated protein A
ND440_RS15190	COG0359	binds to the 23S rRNA
ND440_RS15195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND440_RS15200	COG2965	DNA replication, synthesis of RNA primer
ND440_RS15205	COG0360	Binds together with S18 to 16S ribosomal RNA
ND440_RS15215	COG1073	alpha beta
ND440_RS15235	COG3188	usher protein
ND440_RS15240	COG3121	Chaperone
ND440_RS15260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND440_RS15265	COG0557	exoribonuclease II activity
ND440_RS15270	COG1959	2 iron, 2 sulfur cluster binding
ND440_RS15275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND440_RS15280	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND440_RS15285	COG0330	HflC and HflK could
ND440_RS15290	COG0330	HflC and HflK could
ND440_RS15295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND440_RS15305	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND440_RS15315	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND440_RS15320	COG0802	atpase or kinase
ND440_RS15325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND440_RS15325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND440_RS15330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND440_RS15350	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND440_RS15355	COG1162	GTPase activity
ND440_RS15360	COG0688	phosphatidylethanolamine metabolic process
ND440_RS15365	COG3264	Mechanosensitive ion channel
ND440_RS15365	COG1511	domain protein
ND440_RS15370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND440_RS15375	COG1053	succinate dehydrogenase
ND440_RS15380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND440_RS15385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND440_RS15390	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND440_RS15410	COG3188	usher protein
ND440_RS15430	COG3397	chitin binding
ND440_RS15440	COG1509	lysine 2,3-aminomutase activity
ND440_RS15470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND440_RS15480	COG4232	protein-disulfide reductase activity
ND440_RS15485	COG1309	transcriptional regulator
ND440_RS15505	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND440_RS15525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND440_RS15530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND440_RS15530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND440_RS15550	COG1028	Short-chain dehydrogenase reductase Sdr
ND440_RS15555	COG1083	cytidylyl-transferase
ND440_RS15555	COG2755	lipolytic protein G-D-S-L family
ND440_RS15575	COG2089	acid synthase
ND440_RS15580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND440_RS15585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND440_RS15590	COG1086	Polysaccharide biosynthesis protein
ND440_RS15595	COG0425	Belongs to the sulfur carrier protein TusA family
ND440_RS15600	COG2391	methyltransferase activity
ND440_RS15605	COG1301	dicarboxylic acid transport
ND440_RS15610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND440_RS15615	COG3162	membrane
ND440_RS15620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND440_RS15650	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND440_RS15655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND440_RS15660	COG1739	Uncharacterized protein family UPF0029
ND440_RS15670	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND440_RS15670	COG1024	Enoyl-CoA hydratase
ND440_RS15680	COG0543	2 iron, 2 sulfur cluster binding
ND440_RS15695	COG0250	Participates in transcription elongation, termination and antitermination
ND440_RS15710	COG0805	protein transport
ND440_RS15715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND440_RS15720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND440_RS15725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND440_RS15730	COG3165	ubiquinone biosynthetic process from chorismate
ND440_RS15735	COG2226	methyltransferase
ND440_RS15740	COG1322	Protein conserved in bacteria
ND440_RS15745	COG0586	Pfam SNARE associated Golgi protein
ND440_RS15750	COG1966	Carbon starvation protein
ND440_RS15765	COG0412	Dienelactone hydrolase
ND440_RS15770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND440_RS15775	COG0583	DNA-binding transcription factor activity
ND440_RS15780	COG0697	spore germination
ND440_RS15790	COG0584	glycerophosphoryl diester phosphodiesterase
ND440_RS15800	COG0395	ABC-type sugar transport system, permease component
ND440_RS15805	COG1175	transmembrane transport
ND440_RS15810	COG1653	transport
ND440_RS15845	COG0410	ABC transporter
ND440_RS15855	COG4177	L-phenylalanine transmembrane transporter activity
ND440_RS15875	COG1929	Belongs to the glycerate kinase type-1 family
ND440_RS15880	COG2610	gluconate transmembrane transporter activity
ND440_RS15885	COG3835	regulator
ND440_RS15895	COG2177	Part of the ABC transporter FtsEX involved in
ND440_RS15900	COG2884	Cell division ATP-binding protein ftsE
ND440_RS15905	COG0552	protein localization to endoplasmic reticulum
ND440_RS15905	COG0552	protein localization to endoplasmic reticulum
ND440_RS15910	COG0742	ribosomal rna small subunit methyltransferase
ND440_RS15915	COG3776	membrane
ND440_RS15930	COG3714	YhhN family
ND440_RS15945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND440_RS15955	COG0247	lactate metabolic process
ND440_RS15965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND440_RS15975	COG2271	Major facilitator Superfamily
ND440_RS15980	COG0584	glycerophosphoryl diester phosphodiesterase
ND440_RS15985	COG0561	phosphatase activity
ND440_RS15990	COG2267	carboxylic ester hydrolase activity
ND440_RS15995	COG1280	lysine exporter protein (LysE YggA)
ND440_RS16000	COG0514	ATP-dependent DNA helicase (RecQ)
ND440_RS16005	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND440_RS16010	COG2050	protein possibly involved in aromatic compounds catabolism
ND440_RS16030	COG5564	TIM-barrel signal transduction protein
ND440_RS16035	COG5441	Belongs to the UPF0261 family
ND440_RS16045	COG0210	DNA helicase
ND440_RS16050	COG1011	Hydrolase
ND440_RS16055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND440_RS16060	COG3159	Protein conserved in bacteria
ND440_RS16065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND440_RS16070	COG5567	small periplasmic lipoprotein
ND440_RS16080	COG3072	Adenylate cyclase
ND440_RS16085	COG0181	hydroxymethylbilane synthase activity
ND440_RS16090	COG1587	Uroporphyrinogen-III synthase
ND440_RS16095	COG2959	enzyme of heme biosynthesis
ND440_RS16100	COG3071	HemY protein
ND440_RS16145	COG2244	polysaccharide biosynthetic process
ND440_RS16150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND440_RS16155	COG0456	acetyltransferase
ND440_RS16160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND440_RS16165	COG1088	dTDP-glucose 4,6-dehydratase activity
ND440_RS16170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND440_RS16175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND440_RS16180	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND440_RS16185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND440_RS16190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND440_RS16195	COG3118	belongs to the thioredoxin family
ND440_RS16205	COG0248	Ppx GppA phosphatase
ND440_RS16215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND440_RS16230	COG3397	chitin binding
ND440_RS16240	COG0129	dihydroxy-acid dehydratase activity
ND440_RS16250	COG3978	acetolactate synthase activity
ND440_RS16270	COG3085	chromosome segregation
ND440_RS16275	COG0583	DNA-binding transcription factor activity
ND440_RS16355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_RS16365	COG0678	peroxiredoxin activity
ND440_RS16365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND440_RS16370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND440_RS16405	COG1629	transport
ND440_RS16410	COG0165	Argininosuccinate lyase
ND440_RS16415	COG0137	argininosuccinate synthase activity
ND440_RS16420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND440_RS16465	COG0460	homoserine dehydrogenase
ND440_RS16465	COG0527	aspartate kinase activity
ND440_RS16470	COG0626	cystathionine gamma-synthase activity
ND440_RS16475	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND440_RS16485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND440_RS16490	COG1609	Transcriptional regulator
ND440_RS16495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND440_RS16500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND440_RS16505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND440_RS16510	COG1575	Belongs to the MenA family. Type 1 subfamily
ND440_RS16515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND440_RS16520	COG3074	FtsZ-dependent cytokinesis
ND440_RS16525	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND440_RS16530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND440_RS16535	COG1494	fructose-1,6-bisphosphatase
ND440_RS16540	COG2814	Major facilitator Superfamily
ND440_RS16550	COG3152	Membrane
ND440_RS16565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND440_RS16575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND440_RS16580	COG3678	ATP-independent chaperone mediated protein folding
ND440_RS16585	COG0745	RESPONSE REGULATOR receiver
ND440_RS16590	COG2205	protein histidine kinase activity
ND440_RS16595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND440_RS16600	COG1045	serine acetyltransferase
ND440_RS16605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND440_RS16610	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND440_RS16615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND440_RS16620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND440_RS16625	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND440_RS16630	COG4942	peptidase
ND440_RS16635	COG2861	carbohydrate metabolic process
ND440_RS16650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND440_RS16655	COG0859	PFAM glycosyl transferase family 9
ND440_RS16660	COG0859	PFAM glycosyl transferase family 9
ND440_RS16665	COG1519	Transferase
ND440_RS16685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND440_RS16690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND440_RS16695	COG2003	Belongs to the UPF0758 family
ND440_RS16700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND440_RS16705	COG0756	dUTP diphosphatase activity
ND440_RS16710	COG1309	transcriptional regulator
ND440_RS16715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND440_RS16720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND440_RS16725	COG1561	YicC-like family, N-terminal region
ND440_RS16770	COG5001	Diguanylate cyclase
ND440_RS16775	COG1024	Enoyl-CoA hydratase
ND440_RS16780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND440_RS16790	COG2860	membrane
ND440_RS16795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND440_RS16805	COG1758	RNA polymerase activity
ND440_RS16810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND440_RS16815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND440_RS16820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND440_RS16825	COG0786	glutamate:sodium symporter activity
ND440_RS16830	COG2233	PERMEase
ND440_RS16835	COG2982	Protein involved in outer membrane biogenesis
ND440_RS16840	COG0456	acetyltransferase
ND440_RS16855	COG1011	Hydrolase
ND440_RS16870	COG3852	Histidine kinase
ND440_RS16880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND440_RS16890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND440_RS16895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND440_RS16895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND440_RS16900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND440_RS16905	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND440_RS16910	COG3084	Protein conserved in bacteria
ND440_RS16920	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND440_RS16945	COG2186	Transcriptional regulator
ND440_RS16950	COG1609	Transcriptional regulator
ND440_RS16955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND440_RS16965	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND440_RS16970	COG1129	ABC transporter
ND440_RS16975	COG1869	D-ribose catabolic process
ND440_RS16980	COG3158	transport of potassium into the cell
ND440_RS16985	COG0714	Associated with various cellular activities
ND440_RS16990	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND440_RS17000	COG2502	aspartate--ammonia ligase
ND440_RS17005	COG1522	sequence-specific DNA binding
ND440_RS17010	COG0716	FMN binding
ND440_RS17015	COG0445	tRNA wobble uridine modification
ND440_RS17020	COG0357	Ribosomal RNA small subunit methyltransferase G
ND440_RS17025	COG3312	ion transport
ND440_RS17030	COG0356	it plays a direct role in the translocation of protons across the membrane
ND440_RS17040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND440_RS17050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND440_RS17055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND440_RS17065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND440_RS17080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND440_RS17085	COG0573	inorganic phosphate transmembrane transporter activity
ND440_RS17090	COG0581	inorganic phosphate transmembrane transporter activity
ND440_RS17100	COG0704	Plays a role in the regulation of phosphate uptake
ND440_RS17105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND440_RS17110	COG0765	amino acid transport
ND440_RS17115	COG0765	amino acid transport
ND440_RS17120	COG2252	PERMEase
ND440_RS17125	COG0840	transmembrane signaling receptor activity
ND440_RS17135	COG3121	Chaperone
ND440_RS17150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND440_RS17155	COG0706	membrane insertase activity
ND440_RS17165	COG0594	ribonuclease P activity
ND440_RS17170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND440_RS17175	COG2205	protein histidine kinase activity
ND440_RS17175	COG3437	response regulator, receiver
ND440_RS17175	COG3850	Histidine kinase
ND440_RS17175	COG4999	Histidine kinase
ND440_RS17265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND440_RS17280	COG3549	Plasmid maintenance system killer
ND440_RS17285	COG3093	addiction module antidote protein HigA
ND440_RS17595	COG3344	reverse transcriptase