locus-tag	class	description
ND449_RS00010	COG0592	DNA-directed DNA polymerase activity
ND449_RS00020	COG0187	DNA topoisomerase II activity
ND449_RS00025	COG0561	phosphatase activity
ND449_RS00030	COG0823	Involved in the tonB-independent uptake of proteins
ND449_RS00035	COG5645	(Lipo)protein
ND449_RS00050	COG0569	domain protein
ND449_RS00050	COG2985	domain, Protein
ND449_RS00055	COG3977	Valine--pyruvate aminotransferase
ND449_RS00060	COG2885	chlorophyll binding
ND449_RS00080	COG2818	Glycosylase
ND449_RS00130	COG2213	PTS system mannitol-specific
ND449_RS00130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_RS00140	COG3722	fumarate hydratase activity
ND449_RS00150	COG2258	MOSC domain
ND449_RS00155	COG0840	transmembrane signaling receptor activity
ND449_RS00160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND449_RS00175	COG0437	4 iron, 4 sulfur cluster binding
ND449_RS00180	COG2864	formate dehydrogenase
ND449_RS00190	COG1921	L-seryl-tRNASec selenium transferase activity
ND449_RS00195	COG3276	selenocysteine insertion sequence binding
ND449_RS00200	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ND449_RS00210	COG3274	enterobacterial common antigen metabolic process
ND449_RS00220	COG0582	viral genome integration into host DNA
ND449_RS00255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ND449_RS00260	COG2986	histidine ammonia-lyase
ND449_RS00280	COG2194	sulfuric ester hydrolase activity
ND449_RS00285	COG2197	response regulator
ND449_RS00290	COG3851	Histidine kinase
ND449_RS00295	COG2271	Major facilitator Superfamily
ND449_RS00305	COG0747	negative chemotaxis
ND449_RS00310	COG0601	transmembrane transport
ND449_RS00315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND449_RS00320	COG0444	Belongs to the ABC transporter superfamily
ND449_RS00325	COG4608	Belongs to the ABC transporter superfamily
ND449_RS00330	COG2194	sulfuric ester hydrolase activity
ND449_RS00355	COG1215	transferase activity, transferring glycosyl groups
ND449_RS00360	COG1215	transferase activity, transferring glycosyl groups
ND449_RS00365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ND449_RS00370	COG0457	Tetratricopeptide repeat
ND449_RS00370	COG3118	belongs to the thioredoxin family
ND449_RS00375	COG2199	diguanylate cyclase activity
ND449_RS00375	COG2200	EAL domain
ND449_RS00380	COG1301	dicarboxylic acid transport
ND449_RS00385	COG0612	Peptidase, M16
ND449_RS00390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND449_RS00395	COG1942	4-Oxalocrotonate Tautomerase
ND449_RS00400	COG2200	EAL domain
ND449_RS00405	COG2134	cdp-diacylglycerol pyrophosphatase
ND449_RS00410	COG1295	ribonuclease BN
ND449_RS00420	COG1301	dicarboxylic acid transport
ND449_RS00425	COG0626	cystathionine gamma-synthase activity
ND449_RS00435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_RS00440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ND449_RS00445	COG0339	signal peptide processing
ND449_RS00450	COG0742	ribosomal rna small subunit methyltransferase
ND449_RS00460	COG0589	response to stress
ND449_RS00470	COG0306	phosphate transporter
ND449_RS00475	COG2081	HI0933 family
ND449_RS00485	COG1247	-acetyltransferase
ND449_RS00495	COG1741	Belongs to the pirin family
ND449_RS00500	COG1609	Transcriptional regulator
ND449_RS00505	COG2610	gluconate transmembrane transporter activity
ND449_RS00510	COG3265	gluconokinase activity
ND449_RS00515	COG2095	MarC family integral membrane protein
ND449_RS00520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND449_RS00525	COG3275	phosphorelay sensor kinase activity
ND449_RS00530	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ND449_RS00535	COG1523	belongs to the glycosyl hydrolase 13 family
ND449_RS00540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ND449_RS00545	COG0297	glycogen (starch) synthase activity
ND449_RS00550	COG0058	SHG alpha-glucan phosphorylase activity
ND449_RS00555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND449_RS00560	COG1349	DNA-binding transcription factor activity
ND449_RS00565	COG0705	Rhomboid family
ND449_RS00575	COG2909	trisaccharide binding
ND449_RS00580	COG0058	SHG alpha-glucan phosphorylase activity
ND449_RS00585	COG1640	4-alpha-glucanotransferase
ND449_RS00595	COG1040	competence protein
ND449_RS00600	COG0596	Alpha beta hydrolase
ND449_RS00620	COG1918	ferrous iron import across plasma membrane
ND449_RS00625	COG2183	response to ionizing radiation
ND449_RS00650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND449_RS00665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ND449_RS00675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ND449_RS00680	COG1011	Hydrolase
ND449_RS00690	COG0494	nUDIX hydrolase
ND449_RS00695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ND449_RS00720	COG4796	Type ii and iii secretion system protein
ND449_RS00725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND449_RS00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ND449_RS00755	COG0180	Tryptophanyl-tRNA synthetase
ND449_RS00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ND449_RS00780	COG0402	S-adenosylhomocysteine deaminase activity
ND449_RS00785	COG0738	Major facilitator superfamily
ND449_RS00800	COG1609	Transcriptional regulator
ND449_RS00805	COG1486	melibiose metabolic process
ND449_RS00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND449_RS00825	COG1289	transmembrane transporter activity
ND449_RS00830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND449_RS00835	COG1765	OsmC-like protein
ND449_RS00860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND449_RS00865	COG3954	Phosphoribulokinase
ND449_RS00875	COG0429	hydrolase of the alpha beta-hydrolase fold
ND449_RS00885	COG0859	PFAM glycosyl transferase family 9
ND449_RS00890	COG1216	Glycosyl transferase, family 2
ND449_RS00895	COG0488	(ABC) transporter
ND449_RS00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND449_RS00910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ND449_RS00915	COG1047	Peptidyl-prolyl cis-trans
ND449_RS00925	COG0545	Peptidyl-prolyl cis-trans isomerase
ND449_RS00930	COG2964	Protein conserved in bacteria
ND449_RS00940	COG2923	Belongs to the DsrF TusC family
ND449_RS00945	COG2168	tRNA wobble position uridine thiolation
ND449_RS00950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ND449_RS00955	COG0049	tRNA binding
ND449_RS00965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ND449_RS00980	COG0051	transcription antitermination factor activity, RNA binding
ND449_RS00985	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ND449_RS00995	COG0089	rRNA binding
ND449_RS01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ND449_RS01005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ND449_RS01010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ND449_RS01020	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ND449_RS01025	COG0255	Belongs to the universal ribosomal protein uL29 family
ND449_RS01030	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ND449_RS01035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ND449_RS01045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ND449_RS01070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ND449_RS01075	COG1841	ribosomal large subunit assembly
ND449_RS01080	COG0200	Binds to the 23S rRNA
ND449_RS01085	COG0201	protein transport
ND449_RS01090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND449_RS01095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ND449_RS01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ND449_RS01115	COG0203	ribosomal protein L17
ND449_RS01120	COG0789	Transcriptional regulator
ND449_RS01125	COG3036	rescue of stalled ribosome
ND449_RS01130	COG1970	mechanosensitive ion channel activity
ND449_RS01140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ND449_RS01140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ND449_RS01145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ND449_RS01150	COG0242	peptide deformylase activity
ND449_RS01155	COG0758	DNA mediated transformation
ND449_RS01160	COG2922	Belongs to the Smg family
ND449_RS01165	COG0551	DNA topoisomerase type I activity
ND449_RS01170	COG0009	L-threonylcarbamoyladenylate synthase
ND449_RS01180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ND449_RS01210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND449_RS01215	COG3162	membrane
ND449_RS01220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ND449_RS01225	COG1301	dicarboxylic acid transport
ND449_RS01235	COG2391	methyltransferase activity
ND449_RS01240	COG0425	Belongs to the sulfur carrier protein TusA family
ND449_RS01245	COG1086	Polysaccharide biosynthesis protein
ND449_RS01250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND449_RS01255	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND449_RS01260	COG2089	acid synthase
ND449_RS01280	COG2755	lipolytic protein G-D-S-L family
ND449_RS01280	COG1083	cytidylyl-transferase
ND449_RS01285	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_RS01305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND449_RS01305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_RS01310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ND449_RS01330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND449_RS01350	COG1309	transcriptional regulator
ND449_RS01355	COG4232	protein-disulfide reductase activity
ND449_RS01365	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND449_RS01395	COG1509	lysine 2,3-aminomutase activity
ND449_RS01405	COG3397	chitin binding
ND449_RS01425	COG3188	usher protein
ND449_RS01445	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND449_RS01450	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ND449_RS01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND449_RS01460	COG1053	succinate dehydrogenase
ND449_RS01465	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ND449_RS01470	COG3264	Mechanosensitive ion channel
ND449_RS01470	COG1511	domain protein
ND449_RS01475	COG0688	phosphatidylethanolamine metabolic process
ND449_RS01480	COG1162	GTPase activity
ND449_RS01485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ND449_RS01505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ND449_RS01510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ND449_RS01510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ND449_RS01515	COG0802	atpase or kinase
ND449_RS01520	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND449_RS01530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ND449_RS01540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ND449_RS01545	COG0330	HflC and HflK could
ND449_RS01550	COG0330	HflC and HflK could
ND449_RS01555	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
ND449_RS01560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ND449_RS01565	COG1959	2 iron, 2 sulfur cluster binding
ND449_RS01570	COG0557	exoribonuclease II activity
ND449_RS01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND449_RS01595	COG3121	Chaperone
ND449_RS01600	COG3188	usher protein
ND449_RS01620	COG1073	alpha beta
ND449_RS01630	COG0360	Binds together with S18 to 16S ribosomal RNA
ND449_RS01635	COG2965	DNA replication, synthesis of RNA primer
ND449_RS01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ND449_RS01645	COG0359	binds to the 23S rRNA
ND449_RS01650	COG3061	Opacity-associated protein A
ND449_RS01655	COG0545	Peptidyl-prolyl cis-trans isomerase
ND449_RS01665	COG0737	Belongs to the 5'-nucleotidase family
ND449_RS01670	COG1218	3'(2'),5'-bisphosphate nucleotidase
ND449_RS01675	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
ND449_RS01685	COG1253	flavin adenine dinucleotide binding
ND449_RS01690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND449_RS01695	COG0729	surface antigen
ND449_RS01700	COG2911	Protein conserved in bacteria
ND449_RS01705	COG2105	PFAM AIG2 family protein
ND449_RS01710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ND449_RS01720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND449_RS01735	COG3423	Transcriptional regulator
ND449_RS01750	COG0142	geranyltranstransferase activity
ND449_RS01765	COG0697	spore germination
ND449_RS01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ND449_RS01775	COG0642	Histidine kinase
ND449_RS01780	COG0745	RESPONSE REGULATOR receiver
ND449_RS01785	COG2027	D-alanyl-D-alanine carboxypeptidase
ND449_RS01795	COG1534	Rna-binding protein
ND449_RS01800	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ND449_RS01810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ND449_RS01815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ND449_RS01820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ND449_RS01840	COG0195	Participates in both transcription termination and antitermination
ND449_RS01850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ND449_RS01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ND449_RS01875	COG0513	Belongs to the DEAD box helicase family
ND449_RS01880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ND449_RS01895	COG0826	peptidase U32
ND449_RS01900	COG0826	peptidase U32
ND449_RS01905	COG3154	lipid carrier protein
ND449_RS01910	COG3153	acetyltransferase
ND449_RS01915	COG2827	Endonuclease containing a URI domain
ND449_RS01920	COG0531	amino acid
ND449_RS01925	COG1982	Orn Lys Arg decarboxylase major
ND449_RS01935	COG3787	Belongs to the UPF0306 family
ND449_RS01940	COG0702	epimerase
ND449_RS01945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ND449_RS01950	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ND449_RS01955	COG3454	Phosphonate metabolism
ND449_RS01960	COG4778	phosphonate C-P lyase system protein PhnL
ND449_RS01965	COG4107	phosphonate C-P lyase system protein PhnK
ND449_RS01970	COG3627	carbon phosphorus lyase activity
ND449_RS01975	COG3626	phosphonate metabolism
ND449_RS01980	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ND449_RS01985	COG3624	Phosphonate C-P lyase system protein PhnG
ND449_RS02005	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ND449_RS02020	COG2927	DNA polymerase III (CHI subunit)
ND449_RS02025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ND449_RS02030	COG0795	lipopolysaccharide-transporting ATPase activity
ND449_RS02035	COG0795	lipopolysaccharide-transporting ATPase activity
ND449_RS02075	COG3077	Addiction module antitoxin, RelB DinJ family
ND449_RS02180	COG5492	domain, Protein
ND449_RS02200	COG3119	arylsulfatase activity
ND449_RS02205	COG1349	DNA-binding transcription factor activity
ND449_RS02215	COG2222	sugar isomerase
ND449_RS02220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_RS02225	COG3715	PTS system
ND449_RS02230	COG3716	PTS system mannose fructose sorbose family IID component
ND449_RS02240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND449_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_RS02260	COG0641	radical SAM
ND449_RS02265	COG3119	arylsulfatase activity
ND449_RS02290	COG0859	PFAM glycosyl transferase family 9
ND449_RS02305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_RS02310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_RS02320	COG2376	Dihydroxyacetone kinase
ND449_RS02325	COG1461	Dihydroxyacetone kinase
ND449_RS02330	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ND449_RS02330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_RS02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND449_RS02370	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ND449_RS02385	COG2823	Periplasmic or secreted lipoprotein
ND449_RS02395	COG4667	esterase of the alpha-beta hydrolase superfamily
ND449_RS02400	COG0084	hydrolase, TatD family'
ND449_RS02405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND449_RS02420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ND449_RS02430	COG3726	membrane protein affecting hemolysin expression
ND449_RS02435	COG0560	Phosphoserine phosphatase
ND449_RS02450	COG0488	(ABC) transporter
ND449_RS02475	COG0741	lytic transglycosylase activity
ND449_RS02480	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
ND449_RS02485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ND449_RS02490	COG0406	alpha-ribazole phosphatase activity
ND449_RS02495	COG2207	Transcriptional regulator
ND449_RS02495	COG3708	Transcriptional regulator
ND449_RS02500	COG3045	CreA protein
ND449_RS02505	COG0745	RESPONSE REGULATOR receiver
ND449_RS02540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND449_RS02545	COG0521	Mo-molybdopterin cofactor biosynthetic process
ND449_RS02550	COG0477	Major facilitator Superfamily
ND449_RS02560	COG1584	GPR1 FUN34 yaaH family protein
ND449_RS02565	COG0443	Heat shock 70 kDa protein
ND449_RS02575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND449_RS02580	COG0583	DNA-binding transcription factor activity
ND449_RS02590	COG0196	riboflavin kinase activity
ND449_RS02600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ND449_RS02605	COG1047	Peptidyl-prolyl cis-trans
ND449_RS02610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ND449_RS02625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ND449_RS02635	COG2966	Psort location CytoplasmicMembrane, score
ND449_RS02660	COG2967	ApaG domain
ND449_RS02665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ND449_RS02670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ND449_RS02680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ND449_RS02690	COG0564	pseudouridine synthase activity
ND449_RS02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ND449_RS02700	COG0417	DNA replication proofreading
ND449_RS02705	COG0586	Pfam SNARE associated Golgi protein
ND449_RS02715	COG1178	ABC-type Fe3 transport system permease component
ND449_RS02720	COG4143	(ABC) transporter
ND449_RS02735	COG2814	Major facilitator Superfamily
ND449_RS02745	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ND449_RS02750	COG0473	3-isopropylmalate dehydrogenase activity
ND449_RS02765	COG1022	Amp-dependent synthetase and ligase
ND449_RS02770	COG0028	Belongs to the TPP enzyme family
ND449_RS02795	COG0275	rRNA processing
ND449_RS02800	COG3116	cell division
ND449_RS02805	COG0768	penicillin binding
ND449_RS02810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ND449_RS02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ND449_RS02830	COG0772	Belongs to the SEDS family
ND449_RS02835	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ND449_RS02840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ND449_RS02850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ND449_RS02855	COG0849	cell division
ND449_RS02860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ND449_RS02885	COG0494	nUDIX hydrolase
ND449_RS02905	COG0516	GMP reductase activity
ND449_RS02910	COG1459	type II secretion system
ND449_RS02915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_RS02920	COG4969	Belongs to the N-Me-Phe pilin family
ND449_RS02935	COG3725	Membrane protein required for beta-lactamase induction
ND449_RS02940	COG1113	amino acid transport
ND449_RS02945	COG2186	Transcriptional regulator
ND449_RS02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ND449_RS02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND449_RS02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_RS02970	COG1049	propionate catabolic process, 2-methylcitrate cycle
ND449_RS02975	COG3112	Uncharacterised protein family (UPF0231)
ND449_RS02990	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ND449_RS03000	COG2132	Multicopper oxidase
ND449_RS03010	COG0288	reversible hydration of carbon dioxide
ND449_RS03015	COG1131	(ABC) transporter
ND449_RS03020	COG0842	Transport permease protein
ND449_RS03025	COG0726	polysaccharide deacetylase
ND449_RS03030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ND449_RS03035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ND449_RS03040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ND449_RS03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ND449_RS03050	COG0617	tRNA 3'-terminal CCA addition
ND449_RS03065	COG1489	DNA binding
ND449_RS03070	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ND449_RS03075	COG1643	Atp-dependent helicase
ND449_RS03080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND449_RS03085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ND449_RS03095	COG0316	Belongs to the HesB IscA family
ND449_RS03100	COG2860	membrane
ND449_RS03110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND449_RS03115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ND449_RS03120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND449_RS03130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ND449_RS03135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND449_RS03140	COG3956	TIGRFAM MazG family protein
ND449_RS03145	COG0504	CTP synthase activity
ND449_RS03155	COG0602	queuosine metabolic process
ND449_RS03160	COG0720	synthase
ND449_RS03165	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ND449_RS03175	COG0175	sulfate reduction
ND449_RS03190	COG2234	aminopeptidase activity
ND449_RS03195	COG1648	precorrin-2 dehydrogenase activity
ND449_RS03195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ND449_RS03200	COG0175	sulfate reduction
ND449_RS03205	COG2895	sulfate adenylyltransferase (ATP) activity
ND449_RS03210	COG0529	Catalyzes the synthesis of activated sulfate
ND449_RS03220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ND449_RS03230	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ND449_RS03235	COG0585	pseudouridine synthase activity
ND449_RS03240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ND449_RS03255	COG4942	peptidase
ND449_RS03255	COG1388	LysM domain
ND449_RS03260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ND449_RS03265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ND449_RS03335	COG2205	protein histidine kinase activity
ND449_RS03335	COG0784	Response regulator, receiver
ND449_RS03355	COG0741	lytic transglycosylase activity
ND449_RS03485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND449_RS03505	COG3397	chitin binding
ND449_RS03515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ND449_RS03560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_RS03570	COG3031	protein transport across the cell outer membrane
ND449_RS03595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ND449_RS03595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ND449_RS03610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ND449_RS03615	COG2137	regulation of response to DNA damage stimulus
ND449_RS03620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ND449_RS03625	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ND449_RS03665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND449_RS03670	COG1238	metal cluster binding
ND449_RS03675	COG2918	glutathione biosynthetic process
ND449_RS03680	COG1854	S-ribosylhomocysteine lyase activity
ND449_RS03685	COG4536	flavin adenine dinucleotide binding
ND449_RS03690	COG4137	Cytochrome C assembly protein
ND449_RS03695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ND449_RS03705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ND449_RS03710	COG0336	Belongs to the RNA methyltransferase TrmD family
ND449_RS03715	COG0335	large ribosomal subunit rRNA binding
ND449_RS03720	COG3137	Salt-induced outer membrane protein
ND449_RS03725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ND449_RS03730	COG3279	Response regulator of the LytR AlgR family
ND449_RS03735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND449_RS03740	COG1605	Chorismate mutase
ND449_RS03740	COG0287	Prephenate dehydrogenase
ND449_RS03745	COG0077	Prephenate dehydratase
ND449_RS03745	COG1605	Chorismate mutase
ND449_RS03755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ND449_RS03760	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND449_RS03765	COG0564	pseudouridine synthase activity
ND449_RS03770	COG1496	oxidoreductase activity
ND449_RS03775	COG0542	response to heat
ND449_RS03810	COG3021	interspecies interaction between organisms
ND449_RS03815	COG0741	lytic transglycosylase activity
ND449_RS03815	COG1388	LysM domain
ND449_RS03825	COG2226	methyltransferase
ND449_RS03835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ND449_RS03845	COG1960	acyl-CoA dehydrogenase activity
ND449_RS03850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND449_RS03855	COG0121	glutamine amidotransferase
ND449_RS03860	COG3034	peptidoglycan biosynthetic process
ND449_RS03870	COG1805	sodium ion transport
ND449_RS03875	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND449_RS03880	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND449_RS03885	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ND449_RS03895	COG1477	protein flavinylation
ND449_RS03900	COG2991	Protein conserved in bacteria
ND449_RS03910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND449_RS03915	COG2195	Cleaves the N-terminal amino acid of tripeptides
ND449_RS03920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ND449_RS03925	COG1073	alpha beta
ND449_RS03940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ND449_RS03975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ND449_RS03995	COG4126	flavin adenine dinucleotide binding
ND449_RS04005	COG2974	May be involved in recombination
ND449_RS04010	COG1940	carbohydrate kinase activity
ND449_RS04015	COG0419	ATPase involved in DNA repair
ND449_RS04020	COG0420	3'-5' exonuclease activity
ND449_RS04025	COG0745	RESPONSE REGULATOR receiver
ND449_RS04030	COG5002	protein histidine kinase activity
ND449_RS04045	COG1113	amino acid transport
ND449_RS04050	COG0366	Alpha amylase catalytic
ND449_RS04055	COG0300	oxidoreductase activity
ND449_RS04060	COG0450	alkyl hydroperoxide reductase
ND449_RS04065	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
ND449_RS04080	COG1862	Preprotein translocase
ND449_RS04085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND449_RS04090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ND449_RS04095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ND449_RS04100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND449_RS04100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ND449_RS04105	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ND449_RS04115	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ND449_RS04120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ND449_RS04125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ND449_RS04130	COG0142	geranyltranstransferase activity
ND449_RS04165	COG0693	protein deglycase activity
ND449_RS04170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ND449_RS04175	COG1666	GTP binding
ND449_RS04180	COG2814	Major facilitator Superfamily
ND449_RS04190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ND449_RS04195	COG1845	cytochrome c oxidase, subunit III
ND449_RS04200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ND449_RS04205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ND449_RS04215	COG2223	nitrite transmembrane transporter activity
ND449_RS04220	COG3056	Lipoprotein
ND449_RS04225	COG0271	Belongs to the BolA IbaG family
ND449_RS04235	COG0740	serine-type endopeptidase activity
ND449_RS04240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ND449_RS04245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ND449_RS04250	COG0776	regulation of translation
ND449_RS04255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND449_RS04260	COG1555	photosystem II stabilization
ND449_RS04265	COG0824	Thioesterase
ND449_RS04270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ND449_RS04275	COG4533	DNA binding
ND449_RS04290	COG1522	sequence-specific DNA binding
ND449_RS04295	COG1132	(ABC) transporter
ND449_RS04300	COG1132	(ABC) transporter
ND449_RS04305	COG0347	Belongs to the P(II) protein family
ND449_RS04310	COG0004	ammonium transporteR
ND449_RS04315	COG1946	Acyl-CoA thioesterase
ND449_RS04320	COG3695	enzyme binding
ND449_RS04345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ND449_RS04350	COG0254	rRNA binding
ND449_RS04355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_RS04360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_RS04365	COG1309	transcriptional regulator
ND449_RS04370	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ND449_RS04375	COG1196	nuclear chromosome segregation
ND449_RS04375	COG3264	Mechanosensitive ion channel
ND449_RS04390	COG2832	Protein of unknown function (DUF454)
ND449_RS04395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ND449_RS04435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ND449_RS04440	COG0326	Molecular chaperone. Has ATPase activity
ND449_RS04455	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND449_RS04460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND449_RS04465	COG4651	solute:proton antiporter activity
ND449_RS04465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND449_RS04470	COG0737	Belongs to the 5'-nucleotidase family
ND449_RS04475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ND449_RS04480	COG3735	TraB family
ND449_RS04485	COG2217	Heavy metal translocating P-type atpase
ND449_RS04490	COG0789	Transcriptional regulator
ND449_RS04495	COG1585	Membrane protein implicated in regulation of membrane protease activity
ND449_RS04500	COG0330	HflC and HflK could
ND449_RS04505	COG3118	belongs to the thioredoxin family
ND449_RS04510	COG0300	oxidoreductase activity
ND449_RS04515	COG2755	lipolytic protein G-D-S-L family
ND449_RS04520	COG4181	ATPase activity
ND449_RS04525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ND449_RS04530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ND449_RS04535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ND449_RS04540	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND449_RS04545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ND449_RS04570	COG3188	usher protein
ND449_RS04575	COG3121	Chaperone
ND449_RS04605	COG2501	S4 domain
ND449_RS04610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ND449_RS04625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ND449_RS04630	COG1393	Belongs to the ArsC family
ND449_RS04640	COG1022	Amp-dependent synthetase and ligase
ND449_RS04665	COG3038	cytochrome b561
ND449_RS04695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ND449_RS04705	COG1215	transferase activity, transferring glycosyl groups
ND449_RS04725	COG3250	beta-galactosidase activity
ND449_RS04740	COG1309	transcriptional regulator
ND449_RS04770	COG2197	response regulator
ND449_RS04775	COG1278	Cold shock
ND449_RS04795	COG3706	GGDEF domain
ND449_RS04805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ND449_RS04815	COG2921	Belongs to the UPF0250 family
ND449_RS04820	COG1686	Belongs to the peptidase S11 family
ND449_RS04825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND449_RS04830	COG0772	Belongs to the SEDS family
ND449_RS04835	COG0768	penicillin binding
ND449_RS04840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ND449_RS04845	COG0799	negative regulation of ribosome biogenesis
ND449_RS04850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ND449_RS04855	COG1466	dna polymerase III delta subunit
ND449_RS04860	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ND449_RS04870	COG2888	peptidyl-tyrosine sulfation
ND449_RS04875	COG1126	abc transporter atp-binding protein
ND449_RS04880	COG0765	amino acid transport
ND449_RS04885	COG0765	amino acid transport
ND449_RS04895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ND449_RS04900	COG4535	Mg2 and Co2 transporter CorC
ND449_RS04905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ND449_RS04910	COG1702	phosphate starvation-inducible protein PhoH
ND449_RS04915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ND449_RS04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND449_RS04955	COG0367	asparagine synthase
ND449_RS04960	COG0647	UMP catabolic process
ND449_RS04965	COG1940	carbohydrate kinase activity
ND449_RS04965	COG1846	Transcriptional regulator
ND449_RS04970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ND449_RS04980	COG2190	(PTS) system
ND449_RS04980	COG1263	PTS System
ND449_RS04980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_RS05005	COG0735	belongs to the Fur family
ND449_RS05015	COG0840	transmembrane signaling receptor activity
ND449_RS05025	COG0596	Alpha beta hydrolase
ND449_RS05030	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ND449_RS05035	COG0033	Phosphoglucomutase
ND449_RS05045	COG0745	RESPONSE REGULATOR receiver
ND449_RS05050	COG2205	protein histidine kinase activity
ND449_RS05055	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ND449_RS05060	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ND449_RS05080	COG3272	Protein of unknown function (DUF1722)
ND449_RS05085	COG0415	Belongs to the DNA photolyase family
ND449_RS05090	COG5212	phosphodiesterase
ND449_RS05095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ND449_RS05100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ND449_RS05105	COG1984	allophanate hydrolase subunit 2
ND449_RS05110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ND449_RS05145	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ND449_RS05150	COG1053	succinate dehydrogenase
ND449_RS05155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ND449_RS05160	COG0567	Dehydrogenase, E1 component
ND449_RS05165	COG0508	dehydrogenase complex catalyzes the overall conversion of
ND449_RS05170	COG0045	succinate-CoA ligase (ADP-forming) activity
ND449_RS05175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ND449_RS05180	COG0737	Belongs to the 5'-nucleotidase family
ND449_RS05185	COG1271	oxidase subunit
ND449_RS05190	COG1294	oxidase, subunit
ND449_RS05195	COG4890	Cyd operon protein YbgT
ND449_RS05200	COG3790	cyd operon protein YbgE
ND449_RS05205	COG0824	Thioesterase
ND449_RS05210	COG0811	peptide transport
ND449_RS05215	COG0848	biopolymer transport protein
ND449_RS05220	COG3064	Membrane
ND449_RS05220	COG3064	Membrane
ND449_RS05225	COG0823	Involved in the tonB-independent uptake of proteins
ND449_RS05230	COG2885	chlorophyll binding
ND449_RS05235	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
ND449_RS05270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ND449_RS05280	COG2205	protein histidine kinase activity
ND449_RS05280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_RS05290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND449_RS05295	COG0588	phosphoglycerate mutase activity
ND449_RS05305	COG2017	converts alpha-aldose to the beta-anomer
ND449_RS05315	COG1085	galactose-1-phosphate uridylyltransferase
ND449_RS05320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ND449_RS05335	COG2005	Transcriptional regulator
ND449_RS05335	COG3585	molybdate ion transport
ND449_RS05345	COG0725	ABC transporter, periplasmic molybdate-binding protein
ND449_RS05350	COG4149	molybdate abc transporter
ND449_RS05360	COG0561	phosphatase activity
ND449_RS05365	COG2706	6-phosphogluconolactonase activity
ND449_RS05380	COG0156	8-amino-7-oxononanoate synthase activity
ND449_RS05385	COG2226	methyltransferase
ND449_RS05400	COG0556	nucleotide-excision repair
ND449_RS05405	COG4628	conserved protein (DUF2132)
ND449_RS05420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_RS05425	COG1120	ATPase activity
ND449_RS05430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ND449_RS05435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ND449_RS05445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ND449_RS05450	COG0314	molybdopterin synthase activity
ND449_RS05455	COG0670	Belongs to the BI1 family
ND449_RS05460	COG0842	Transport permease protein
ND449_RS05465	COG0842	Transport permease protein
ND449_RS05470	COG1131	(ABC) transporter
ND449_RS05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_RS05480	COG1309	transcriptional regulator
ND449_RS05485	COG0513	Belongs to the DEAD box helicase family
ND449_RS05490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND449_RS05500	COG1686	Belongs to the peptidase S11 family
ND449_RS05505	COG0277	FAD linked oxidase domain protein
ND449_RS05525	COG2261	transglycosylase associated protein
ND449_RS05535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ND449_RS05545	COG3639	organic phosphonate transmembrane transporter activity
ND449_RS05550	COG4807	Protein conserved in bacteria
ND449_RS05555	COG2897	thiosulfate sulfurtransferase activity
ND449_RS05560	COG1732	Glycine betaine
ND449_RS05565	COG1174	glycine betaine transport
ND449_RS05570	COG1125	glycine betaine transport
ND449_RS05575	COG1174	glycine betaine transport
ND449_RS05580	COG0531	amino acid
ND449_RS05585	COG1982	Orn Lys Arg decarboxylase major
ND449_RS05595	COG0697	spore germination
ND449_RS05610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ND449_RS05615	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
ND449_RS05620	COG1126	abc transporter atp-binding protein
ND449_RS05625	COG0765	amino acid transport
ND449_RS05630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_RS05650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ND449_RS05655	COG2239	Acts as a magnesium transporter
ND449_RS05660	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND449_RS05665	COG0488	(ABC) transporter
ND449_RS05670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND449_RS05675	COG0303	'Molybdopterin
ND449_RS05695	COG0583	DNA-binding transcription factor activity
ND449_RS05700	COG0477	Major facilitator Superfamily
ND449_RS05705	COG0302	gtp cyclohydrolase
ND449_RS05710	COG2311	Membrane
ND449_RS05735	COG2949	membrane
ND449_RS05740	COG0281	malic enzyme
ND449_RS05750	COG0583	DNA-binding transcription factor activity
ND449_RS05760	COG1346	cytolysis
ND449_RS05765	COG1380	Effector of murein hydrolase LrgA
ND449_RS05775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND449_RS05775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ND449_RS05780	COG0489	protein tyrosine kinase activity
ND449_RS05785	COG0572	uridine kinase
ND449_RS05790	COG0717	Belongs to the dCTP deaminase family
ND449_RS05795	COG2982	Protein involved in outer membrane biogenesis
ND449_RS05800	COG3069	C4-dicarboxylate transmembrane transporter activity
ND449_RS05805	COG1253	flavin adenine dinucleotide binding
ND449_RS05810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND449_RS05815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ND449_RS05820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ND449_RS05830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ND449_RS05830	COG0140	phosphoribosyl-ATP diphosphatase activity
ND449_RS05840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ND449_RS05850	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND449_RS05850	COG0131	Imidazoleglycerol-phosphate dehydratase
ND449_RS05855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ND449_RS05860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ND449_RS05875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND449_RS05880	COG0625	glutathione transferase activity
ND449_RS05895	COG0626	cystathionine gamma-synthase activity
ND449_RS05905	COG1686	Belongs to the peptidase S11 family
ND449_RS05910	COG1760	l-serine dehydratase
ND449_RS05915	COG0814	amino acid
ND449_RS05920	COG1349	DNA-binding transcription factor activity
ND449_RS05930	COG0671	phosphoesterase, PA-phosphatase related
ND449_RS05940	COG0569	domain protein
ND449_RS05940	COG2985	domain, Protein
ND449_RS05960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ND449_RS05965	COG3842	ATPase activity
ND449_RS05970	COG1176	ABC-type spermidine putrescine transport system, permease component I
ND449_RS05975	COG1177	transmembrane transport
ND449_RS05990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_RS05995	COG4160	amino acid transport
ND449_RS06000	COG4215	(ABC) transporter
ND449_RS06005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_RS06010	COG1126	abc transporter atp-binding protein
ND449_RS06020	COG0393	Putative heavy-metal-binding
ND449_RS06025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND449_RS06030	COG0702	epimerase
ND449_RS06035	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ND449_RS06040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND449_RS06045	COG1151	hydroxylamine reductase activity
ND449_RS06050	COG2431	L-lysine efflux transmembrane transporter activity
ND449_RS06055	COG3593	DNA synthesis involved in DNA repair
ND449_RS06060	COG2990	Protein conserved in bacteria
ND449_RS06065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_RS06075	COG1278	Cold shock
ND449_RS06080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ND449_RS06085	COG0542	response to heat
ND449_RS06090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ND449_RS06100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ND449_RS06110	COG0492	ferredoxin-NADP+ reductase activity
ND449_RS06115	COG1522	sequence-specific DNA binding
ND449_RS06120	COG1674	ftsk spoiiie
ND449_RS06120	COG3107	peptidoglycan biosynthetic process
ND449_RS06125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ND449_RS06130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ND449_RS06135	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ND449_RS06140	COG2814	Major facilitator Superfamily
ND449_RS06145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ND449_RS06150	COG1882	Formate acetyltransferase
ND449_RS06155	COG2116	formate transmembrane transporter activity
ND449_RS06160	COG1944	ATP diphosphatase activity
ND449_RS06165	COG0252	asparaginase activity
ND449_RS06175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ND449_RS06185	COG0539	negative regulation of cytoplasmic translation
ND449_RS06195	COG2333	competence protein COMEC
ND449_RS06195	COG0658	competence protein
ND449_RS06205	COG1663	tetraacyldisaccharide 4'-kinase activity
ND449_RS06210	COG5383	Protein conserved in bacteria
ND449_RS06220	COG1278	Cold shock
ND449_RS06225	COG2835	tetraacyldisaccharide 4'-kinase activity
ND449_RS06230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ND449_RS06235	COG3173	Aminoglycoside phosphotransferase
ND449_RS06240	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ND449_RS06245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND449_RS06250	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ND449_RS06260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ND449_RS06265	COG2989	Protein conserved in bacteria
ND449_RS06270	COG3108	Peptidase M15
ND449_RS06275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ND449_RS06280	COG1448	Aminotransferase
ND449_RS06295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ND449_RS06300	COG0308	aminopeptidase N
ND449_RS06305	COG0167	dihydroorotate dehydrogenase activity
ND449_RS06315	COG0633	Ferredoxin
ND449_RS06315	COG3217	Mosc domain protein beta barrel domain protein
ND449_RS06320	COG0116	Belongs to the methyltransferase superfamily
ND449_RS06320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND449_RS06325	COG0488	(ABC) transporter
ND449_RS06330	COG2995	paraquat-inducible protein a
ND449_RS06335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND449_RS06335	COG3008	intermembrane lipid transfer
ND449_RS06340	COG3009	Protein conserved in bacteria
ND449_RS06345	COG3130	regulation of translation
ND449_RS06350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ND449_RS06355	COG1067	ATP-dependent peptidase activity
ND449_RS06360	COG3120	sequence-specific DNA binding
ND449_RS06370	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
ND449_RS06375	COG3070	regulator of competence-specific genes
ND449_RS06380	COG1289	transmembrane transporter activity
ND449_RS06385	COG3304	Inner membrane component domain
ND449_RS06390	COG0210	DNA helicase
ND449_RS06395	COG1803	Methylglyoxal synthase
ND449_RS06405	COG1832	CoA-binding protein
ND449_RS06410	COG3785	DNA binding
ND449_RS06415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ND449_RS06420	COG1254	Belongs to the acylphosphatase family
ND449_RS06425	COG2920	part of a sulfur-relay system
ND449_RS06435	COG0288	reversible hydration of carbon dioxide
ND449_RS06455	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ND449_RS06460	COG2943	transferase activity, transferring hexosyl groups
ND449_RS06475	COG0675	Transposase, IS605 OrfB family
ND449_RS06490	COG1560	Kdo2-lipid A biosynthetic process
ND449_RS06500	COG0628	permease
ND449_RS06525	COG0418	dihydroorotase activity
ND449_RS06530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ND449_RS06540	COG1530	ribonuclease E activity
ND449_RS06545	COG0564	pseudouridine synthase activity
ND449_RS06550	COG0424	maF-like protein
ND449_RS06555	COG1399	metal-binding, possibly nucleic acid-binding protein
ND449_RS06560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ND449_RS06570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ND449_RS06575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ND449_RS06585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ND449_RS06590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND449_RS06595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ND449_RS06600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ND449_RS06605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ND449_RS06610	COG0470	DNA polymerase III
ND449_RS06615	COG0084	hydrolase, TatD family'
ND449_RS06620	COG1263	PTS System
ND449_RS06620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_RS06625	COG0537	adenosine 5'-monophosphoramidase activity
ND449_RS06630	COG5633	Lipoprotein
ND449_RS06635	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
ND449_RS06650	COG3150	esterase
ND449_RS06655	COG1252	NADH dehydrogenase
ND449_RS06660	COG3134	Outer membrane lipoprotein
ND449_RS06665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ND449_RS06670	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND449_RS06680	COG4591	ABC-type transport system involved in lipoprotein release permease component
ND449_RS06700	COG2850	peptidyl-arginine hydroxylation
ND449_RS06705	COG2205	protein histidine kinase activity
ND449_RS06710	COG0745	RESPONSE REGULATOR receiver
ND449_RS06720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ND449_RS06725	COG2915	High frequency lysogenization protein hflD homolog
ND449_RS06730	COG0482	sulfurtransferase activity
ND449_RS06740	COG1187	pseudouridine synthase activity
ND449_RS06745	COG0538	isocitrate dehydrogenase activity
ND449_RS06750	COG2771	luxR family
ND449_RS06755	COG3916	Acyl-homoserine-lactone synthase
ND449_RS06760	COG2723	6-phospho-beta-galactosidase activity
ND449_RS06770	COG0339	signal peptide processing
ND449_RS06775	COG0840	transmembrane signaling receptor activity
ND449_RS06800	COG0675	Transposase, IS605 OrfB family
ND449_RS06810	COG4565	transcriptional regulatory protein
ND449_RS06815	COG3290	protein histidine kinase activity
ND449_RS06820	COG0471	metal ion transport
ND449_RS06860	COG4977	sequence-specific DNA binding
ND449_RS06865	COG1702	phosphate starvation-inducible protein PhoH
ND449_RS06870	COG0387	Pfam Sodium calcium exchanger
ND449_RS06875	COG2375	cellular response to nickel ion
ND449_RS06880	COG3850	Histidine kinase
ND449_RS06890	COG1294	oxidase, subunit
ND449_RS06895	COG1271	oxidase subunit
ND449_RS06900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND449_RS06905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ND449_RS06910	COG3138	arginine N-succinyltransferase
ND449_RS06920	COG3724	N-succinylarginine dihydrolase activity
ND449_RS06940	COG1228	amidohydrolase
ND449_RS06950	COG0402	S-adenosylhomocysteine deaminase activity
ND449_RS06970	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ND449_RS06975	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ND449_RS06980	COG3383	formate dehydrogenase (NAD+) activity
ND449_RS06985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_RS06990	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ND449_RS07000	COG3260	NADH ubiquinone oxidoreductase 20
ND449_RS07005	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_RS07010	COG3261	NADH dehydrogenase
ND449_RS07010	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ND449_RS07015	COG0650	Formate hydrogenlyase subunit 4
ND449_RS07020	COG0651	ATP synthesis coupled electron transport
ND449_RS07025	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_RS07035	COG0375	protein maturation
ND449_RS07040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ND449_RS07045	COG0298	carbon dioxide binding
ND449_RS07050	COG0409	Hydrogenase expression formation protein
ND449_RS07055	COG0309	Hydrogenase expression formation protein (HypE)
ND449_RS07090	COG2207	Transcriptional regulator
ND449_RS07090	COG3708	Transcriptional regulator
ND449_RS07095	COG0012	GTP binding
ND449_RS07105	COG0193	aminoacyl-tRNA hydrolase activity
ND449_RS07115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ND449_RS07125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ND449_RS07130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ND449_RS07135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ND449_RS07140	COG2890	protein-(glutamine-N5) methyltransferase activity
ND449_RS07155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ND449_RS07160	COG0659	secondary active sulfate transmembrane transporter activity
ND449_RS07165	COG3706	GGDEF domain
ND449_RS07190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND449_RS07200	COG3381	protein complex oligomerization
ND449_RS07220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_RS07230	COG0673	inositol 2-dehydrogenase activity
ND449_RS07235	COG0728	peptidoglycan biosynthetic process
ND449_RS07260	COG3102	Protein conserved in bacteria
ND449_RS07265	COG3142	Participates in the control of copper homeostasis
ND449_RS07280	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ND449_RS07285	COG1801	Protein of unknown function DUF72
ND449_RS07295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ND449_RS07300	COG0494	nUDIX hydrolase
ND449_RS07310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ND449_RS07320	COG2255	four-way junction helicase activity
ND449_RS07325	COG3104	oligopeptide transport
ND449_RS07330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND449_RS07335	COG1121	(ABC) transporter
ND449_RS07340	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ND449_RS07345	COG0739	heme binding
ND449_RS07350	COG1560	Kdo2-lipid A biosynthetic process
ND449_RS07355	COG0469	pyruvate kinase activity
ND449_RS07360	COG1737	Transcriptional regulator
ND449_RS07365	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ND449_RS07370	COG0800	Aldolase
ND449_RS07380	COG2076	Multidrug Resistance protein
ND449_RS07385	COG0251	oxidation-reduction process
ND449_RS07390	COG1199	ATP-dependent helicase activity
ND449_RS07395	COG1214	PFAM Peptidase M22, glycoprotease
ND449_RS07400	COG3065	identical protein binding
ND449_RS07405	COG0318	PFAM AMP-dependent synthetase and ligase
ND449_RS07410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ND449_RS07415	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ND449_RS07420	COG2894	cell division
ND449_RS07425	COG0850	regulation of cytokinetic process
ND449_RS07430	COG3100	YcgL domain-containing protein
ND449_RS07435	COG0179	Fumarylacetoacetate (FAA) hydrolase
ND449_RS07440	COG2983	Belongs to the UPF0260 family
ND449_RS07460	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ND449_RS07470	COG2719	SpoVR family
ND449_RS07475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ND449_RS07480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ND449_RS07485	COG2814	Major facilitator Superfamily
ND449_RS07495	COG2200	EAL domain
ND449_RS07495	COG2202	Pas domain
ND449_RS07495	COG2199	diguanylate cyclase activity
ND449_RS07515	COG2718	Belongs to the UPF0229 family
ND449_RS07520	COG2766	serine protein kinase
ND449_RS07530	COG3713	MltA-interacting MipA family protein
ND449_RS07535	COG2194	sulfuric ester hydrolase activity
ND449_RS07550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ND449_RS07555	COG3139	Protein of unknown function (DUF1315)
ND449_RS07560	COG1335	isochorismatase
ND449_RS07565	COG0252	asparaginase activity
ND449_RS07570	COG0616	signal peptide processing
ND449_RS07575	COG0778	Nitroreductase
ND449_RS07585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ND449_RS07595	COG0494	nUDIX hydrolase
ND449_RS07600	COG0708	Exodeoxyribonuclease III
ND449_RS07630	COG0788	formyltetrahydrofolate deformylase activity
ND449_RS07640	COG1752	Esterase of the alpha-beta hydrolase superfamily
ND449_RS07645	COG0745	RESPONSE REGULATOR receiver
ND449_RS07665	COG1454	alcohol dehydrogenase
ND449_RS07665	COG1012	belongs to the aldehyde dehydrogenase family
ND449_RS07675	COG2095	MarC family integral membrane protein
ND449_RS07680	COG4166	transmembrane transport
ND449_RS07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ND449_RS07710	COG3099	Belongs to the UPF0263 family
ND449_RS07715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND449_RS07740	COG2350	Protein conserved in bacteria
ND449_RS07755	COG3710	Transcriptional regulator
ND449_RS07790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
ND449_RS07815	COG0727	PFAM Uncharacterised protein family (UPF0153)
ND449_RS07820	COG3047	cAMP biosynthetic process
ND449_RS07835	COG0133	tryptophan synthase activity
ND449_RS07840	COG0135	phosphoribosylanthranilate isomerase activity
ND449_RS07840	COG0134	indole-3-glycerol-phosphate synthase activity
ND449_RS07850	COG0512	Glutamine amidotransferase of anthranilate synthase
ND449_RS07860	COG0613	PHP domain protein
ND449_RS07865	COG0009	L-threonylcarbamoyladenylate synthase
ND449_RS07885	COG1187	pseudouridine synthase activity
ND449_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_RS07900	COG0616	signal peptide processing
ND449_RS07915	COG0583	DNA-binding transcription factor activity
ND449_RS07930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ND449_RS07940	COG0671	phosphoesterase, PA-phosphatase related
ND449_RS07945	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ND449_RS07950	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ND449_RS07970	COG0023	Translation Initiation Factor
ND449_RS07980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ND449_RS07985	COG5002	protein histidine kinase activity
ND449_RS07985	COG3447	MASE1 domain protein
ND449_RS07985	COG5001	Diguanylate cyclase
ND449_RS07990	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ND449_RS07995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ND449_RS08005	COG4659	FMN binding
ND449_RS08015	COG3708	Transcriptional regulator
ND449_RS08015	COG2207	Transcriptional regulator
ND449_RS08030	COG4657	Part of a membrane complex involved in electron transport
ND449_RS08040	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ND449_RS08050	COG0673	inositol 2-dehydrogenase activity
ND449_RS08055	COG0385	Bile acid
ND449_RS08060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ND449_RS08065	COG5339	Protein conserved in bacteria
ND449_RS08070	COG1482	cell wall glycoprotein biosynthetic process
ND449_RS08075	COG0114	fumarate hydratase activity
ND449_RS08085	COG1940	carbohydrate kinase activity
ND449_RS08090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ND449_RS08110	COG1742	UPF0060 membrane protein
ND449_RS08115	COG4221	oxidoreductase activity
ND449_RS08120	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND449_RS08140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ND449_RS08180	COG1011	Hydrolase
ND449_RS08190	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ND449_RS08195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ND449_RS08200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ND449_RS08205	COG0589	response to stress
ND449_RS08235	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ND449_RS08240	COG3623	hexulose-6-phosphate isomerase
ND449_RS08245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ND449_RS08250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ND449_RS08260	COG0531	amino acid
ND449_RS08270	COG0745	RESPONSE REGULATOR receiver
ND449_RS08275	COG2205	protein histidine kinase activity
ND449_RS08290	COG2207	Transcriptional regulator
ND449_RS08295	COG1881	PFAM PEBP family protein
ND449_RS08305	COG3591	Belongs to the peptidase S1B family
ND449_RS08310	COG1643	Atp-dependent helicase
ND449_RS08315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ND449_RS08320	COG3784	Protein of unknown function (DUF1318)
ND449_RS08335	COG2911	Protein conserved in bacteria
ND449_RS08340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ND449_RS08345	COG3187	Heat shock protein
ND449_RS08350	COG3042	response to heat
ND449_RS08355	COG1285	pathogenesis
ND449_RS08365	COG0674	pyruvate-flavodoxin oxidoreductase activity
ND449_RS08365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ND449_RS08365	COG1013	pyruvate-flavodoxin oxidoreductase activity
ND449_RS08365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_RS08380	COG4166	transmembrane transport
ND449_RS08385	COG2866	Carboxypeptidase
ND449_RS08390	COG4948	Mandelate Racemase Muconate Lactonizing
ND449_RS08395	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ND449_RS08405	COG5642	Protein of unknown function (DUF2384)
ND449_RS08410	COG5654	RES domain protein
ND449_RS08415	COG3768	UPF0283 membrane protein
ND449_RS08420	COG3106	COG3106 Predicted ATPase
ND449_RS08430	COG1983	PspC domain protein
ND449_RS08440	COG1842	Phage shock protein A
ND449_RS08445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ND449_RS08460	COG4166	transmembrane transport
ND449_RS08470	COG4171	peptide transport system, permease
ND449_RS08475	COG4172	Belongs to the ABC transporter superfamily
ND449_RS08480	COG4172	Belongs to the ABC transporter superfamily
ND449_RS08490	COG3104	oligopeptide transport
ND449_RS08500	COG0484	heat shock protein binding
ND449_RS08545	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ND449_RS08550	COG3133	Outer membrane lipoprotein
ND449_RS08555	COG1846	Transcriptional regulator
ND449_RS08565	COG4989	oxidoreductase activity
ND449_RS08570	COG3313	Fe-S protein
ND449_RS08575	COG2194	sulfuric ester hydrolase activity
ND449_RS08580	COG1309	transcriptional regulator
ND449_RS08585	COG1902	pentaerythritol trinitrate reductase activity
ND449_RS08600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ND449_RS08605	COG0791	NLP P60 protein
ND449_RS08610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ND449_RS08620	COG1609	Transcriptional regulator
ND449_RS08625	COG0583	DNA-binding transcription factor activity
ND449_RS08630	COG2814	Major facilitator Superfamily
ND449_RS08635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ND449_RS08640	COG0307	riboflavin synthase, alpha
ND449_RS08675	COG1376	ErfK ybiS ycfS ynhG family protein
ND449_RS08675	COG1388	LysM domain
ND449_RS08680	COG2166	iron-sulfur cluster assembly
ND449_RS08690	COG0719	Fe-S assembly protein
ND449_RS08695	COG0396	ATPase activity
ND449_RS08700	COG0719	Fe-S assembly protein
ND449_RS08705	COG0316	Belongs to the HesB IscA family
ND449_RS08710	COG2050	protein possibly involved in aromatic compounds catabolism
ND449_RS08715	COG0277	FAD linked oxidase domain protein
ND449_RS08715	COG0247	lactate metabolic process
ND449_RS08720	COG0628	permease
ND449_RS08730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ND449_RS08730	COG0574	Belongs to the PEP-utilizing enzyme family
ND449_RS08735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ND449_RS08740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ND449_RS08750	COG4771	TonB-dependent receptor
ND449_RS08755	COG3720	iron ion transport
ND449_RS08760	COG4558	Periplasmic binding protein
ND449_RS08765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_RS08770	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ND449_RS08780	COG0095	Lipoate-protein ligase
ND449_RS08785	COG0791	NLP P60 protein
ND449_RS08790	COG2076	Multidrug Resistance protein
ND449_RS08795	COG2076	Multidrug Resistance protein
ND449_RS08800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ND449_RS08815	COG0463	Glycosyl transferase, family 2
ND449_RS08820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND449_RS08830	COG4139	cobalamin transport
ND449_RS08875	COG2184	nucleotidyltransferase activity
ND449_RS08890	COG2314	TM2 domain
ND449_RS08895	COG0776	regulation of translation
ND449_RS08965	COG0803	Belongs to the bacterial solute-binding protein 9 family
ND449_RS08970	COG1121	(ABC) transporter
ND449_RS08975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND449_RS08980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ND449_RS08985	COG3001	Fructosamine kinase
ND449_RS08995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ND449_RS09000	COG1988	membrane-bound metal-dependent
ND449_RS09005	COG1823	symporter activity
ND449_RS09010	COG3023	N-Acetylmuramoyl-L-alanine amidase
ND449_RS09020	COG2814	Major facilitator Superfamily
ND449_RS09030	COG0501	Belongs to the peptidase M48B family
ND449_RS09035	COG0793	Belongs to the peptidase S41A family
ND449_RS09045	COG1956	GAF domain-containing protein
ND449_RS09050	COG2995	paraquat-inducible protein a
ND449_RS09055	COG3008	intermembrane lipid transfer
ND449_RS09060	COG3706	GGDEF domain
ND449_RS09060	COG2203	Gaf domain
ND449_RS09060	COG4251	negative regulation of phosphorylation
ND449_RS09060	COG5001	Diguanylate cyclase
ND449_RS09270	COG3772	lysozyme
ND449_RS09320	COG1674	ftsk spoiiie
ND449_RS09320	COG1178	ABC-type Fe3 transport system permease component
ND449_RS09440	COG1276	copper resistance
ND449_RS09445	COG2372	response to copper ion
ND449_RS09450	COG1528	Iron-storage protein
ND449_RS09470	COG1770	oligopeptidase
ND449_RS09480	COG3097	Belongs to the UPF0267 family
ND449_RS09485	COG3141	response to X-ray
ND449_RS09490	COG0513	Belongs to the DEAD box helicase family
ND449_RS09510	COG0494	nUDIX hydrolase
ND449_RS09515	COG1760	l-serine dehydratase
ND449_RS09520	COG1253	flavin adenine dinucleotide binding
ND449_RS09525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_RS09525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_RS09530	COG3715	PTS system
ND449_RS09535	COG3716	PTS system mannose fructose sorbose family IID component
ND449_RS09540	COG4811	Protein of unknown function (DUF986)
ND449_RS09545	COG1971	Probably functions as a manganese efflux pump
ND449_RS09565	COG1960	acyl-CoA dehydrogenase activity
ND449_RS09575	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ND449_RS09605	COG2226	methyltransferase
ND449_RS09610	COG0768	penicillin binding
ND449_RS09615	COG1496	oxidoreductase activity
ND449_RS09635	COG1113	amino acid transport
ND449_RS09670	COG2207	Transcriptional regulator
ND449_RS09690	COG1132	(ABC) transporter
ND449_RS09700	COG2203	Gaf domain
ND449_RS09700	COG3706	GGDEF domain
ND449_RS09700	COG5001	Diguanylate cyclase
ND449_RS09700	COG4251	negative regulation of phosphorylation
ND449_RS09720	COG1181	Belongs to the D-alanine--D-alanine ligase family
ND449_RS09740	COG1278	Cold shock
ND449_RS09745	COG1278	Cold shock
ND449_RS09750	COG1278	Cold shock
ND449_RS09765	COG1917	Cupin 2, conserved barrel domain protein
ND449_RS09765	COG2169	Transcriptional regulator
ND449_RS09770	COG1447	Phosphotransferase system cellobiose-specific component IIA
ND449_RS09775	COG2723	6-phospho-beta-galactosidase activity
ND449_RS09780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND449_RS09785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ND449_RS09790	COG1187	pseudouridine synthase activity
ND449_RS09800	COG3122	Protein conserved in bacteria
ND449_RS09805	COG1757	Na H antiporter
ND449_RS09820	COG2235	arginine
ND449_RS09835	COG0076	glutamate decarboxylase activity
ND449_RS09840	COG0531	amino acid
ND449_RS09875	COG2153	protein acetylation
ND449_RS09880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ND449_RS09910	COG0840	transmembrane signaling receptor activity
ND449_RS09915	COG2801	Transposase and inactivated derivatives
ND449_RS09935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ND449_RS09940	COG0322	excinuclease ABC activity
ND449_RS09945	COG2197	response regulator
ND449_RS09970	COG1113	amino acid transport
ND449_RS09980	COG0531	amino acid
ND449_RS09985	COG3710	Transcriptional regulator
ND449_RS09990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ND449_RS09995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND449_RS09995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ND449_RS09995	COG0506	proline dehydrogenase activity
ND449_RS10000	COG1126	abc transporter atp-binding protein
ND449_RS10005	COG0765	amino acid transport
ND449_RS10010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_RS10015	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ND449_RS10025	COG1191	sigma factor activity
ND449_RS10065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ND449_RS10070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ND449_RS10085	COG1677	Flagellar hook-basal body complex protein FliE
ND449_RS10095	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ND449_RS10100	COG1317	bacterial-type flagellum organization
ND449_RS10105	COG1157	protein secretion by the type III secretion system
ND449_RS10120	COG1580	Controls the rotational direction of flagella during chemotaxis
ND449_RS10200	COG1558	bacterial-type flagellum-dependent cell motility
ND449_RS10205	COG1815	bacterial-type flagellum-dependent cell motility
ND449_RS10215	COG2747	anti-sigma28 factor FlgM
ND449_RS10220	COG3418	PFAM FlgN family protein
ND449_RS10230	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND449_RS10235	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ND449_RS10240	COG4935	Belongs to the peptidase S8 family
ND449_RS10240	COG1404	Belongs to the peptidase S8 family
ND449_RS10245	COG2197	response regulator
ND449_RS10260	COG3188	usher protein
ND449_RS10265	COG3121	Chaperone
ND449_RS10275	COG3539	Fimbrial protein
ND449_RS10305	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ND449_RS10310	COG0745	RESPONSE REGULATOR receiver
ND449_RS10320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ND449_RS10325	COG0840	transmembrane signaling receptor activity
ND449_RS10330	COG0840	transmembrane signaling receptor activity
ND449_RS10335	COG0835	chemotaxis
ND449_RS10340	COG2198	Histidine kinase
ND449_RS10340	COG0643	Histidine kinase
ND449_RS10345	COG1360	Flagellar Motor Protein
ND449_RS10365	COG0589	response to stress
ND449_RS10370	COG1285	pathogenesis
ND449_RS10375	COG0840	transmembrane signaling receptor activity
ND449_RS10395	COG1609	Transcriptional regulator
ND449_RS10405	COG0604	alcohol dehydrogenase
ND449_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_RS10405	COG3321	synthase
ND449_RS10440	COG0582	viral genome integration into host DNA
ND449_RS10455	COG3423	Transcriptional regulator
ND449_RS10490	COG3451	type IV secretory pathway VirB4
ND449_RS10510	COG3736	Type IV secretory pathway, component VirB8
ND449_RS10525	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ND449_RS10540	COG4227	nucleotidyltransferase activity
ND449_RS10605	COG0471	metal ion transport
ND449_RS10620	COG3051	citrate lyase alpha subunit
ND449_RS10625	COG2301	Belongs to the HpcH HpaI aldolase family
ND449_RS10630	COG3052	prosthetic group binding
ND449_RS10635	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ND449_RS10640	COG3290	protein histidine kinase activity
ND449_RS10645	COG4565	transcriptional regulatory protein
ND449_RS10660	COG2271	Major facilitator Superfamily
ND449_RS10665	COG1840	ABC-type Fe3 transport system, periplasmic component
ND449_RS10675	COG3842	ATPase activity
ND449_RS10695	COG1289	transmembrane transporter activity
ND449_RS10705	COG2925	Exonuclease
ND449_RS10710	COG0531	amino acid
ND449_RS10715	COG4771	TonB-dependent receptor
ND449_RS10725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_RS10735	COG0833	amino acid
ND449_RS10740	COG0583	DNA-binding transcription factor activity
ND449_RS10750	COG2855	membrane
ND449_RS10755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ND449_RS10760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND449_RS10760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ND449_RS10760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ND449_RS10765	COG1105	Belongs to the carbohydrate kinase PfkB family
ND449_RS10780	COG3005	denitrification pathway
ND449_RS10785	COG0243	molybdopterin cofactor binding
ND449_RS10805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ND449_RS10815	COG0246	Mannitol dehydrogenase
ND449_RS10825	COG0523	cobalamin synthesis protein
ND449_RS10830	COG0671	phosphoesterase, PA-phosphatase related
ND449_RS10835	COG0791	NLP P60 protein
ND449_RS10840	COG2200	EAL domain
ND449_RS10845	COG4166	transmembrane transport
ND449_RS10850	COG4174	ABC transporter (Permease)
ND449_RS10855	COG4239	(ABC) transporter, permease
ND449_RS10860	COG4172	Belongs to the ABC transporter superfamily
ND449_RS10870	COG2814	Major facilitator Superfamily
ND449_RS10875	COG1187	pseudouridine synthase activity
ND449_RS10880	COG1061	Type III restriction enzyme res subunit
ND449_RS10895	COG3082	Protein of unknown function (DUF1414)
ND449_RS10900	COG3083	sulfuric ester hydrolase activity
ND449_RS10925	COG3778	Protein conserved in bacteria
ND449_RS10930	COG3299	homolog of phage Mu protein gp47
ND449_RS10975	COG4386	tail sheath protein
ND449_RS11025	COG4626	Terminase
ND449_RS11025	COG1802	Transcriptional regulator
ND449_RS11050	COG1876	peptidase activity
ND449_RS11080	COG2815	serine threonine protein kinase
ND449_RS11080	COG0515	serine threonine protein kinase
ND449_RS11095	COG1403	HNH endonuclease
ND449_RS11110	COG4725	Belongs to the MT-A70-like family
ND449_RS11115	COG4626	Terminase
ND449_RS11115	COG1802	Transcriptional regulator
ND449_RS11150	COG5532	Uncharacterized conserved protein (DUF2303)
ND449_RS11155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND449_RS11205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ND449_RS11210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_RS11230	COG2223	nitrite transmembrane transporter activity
ND449_RS11235	COG0642	Histidine kinase
ND449_RS11235	COG2198	Histidine kinase
ND449_RS11245	COG2205	protein histidine kinase activity
ND449_RS11245	COG0784	Response regulator, receiver
ND449_RS11255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ND449_RS11260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND449_RS11270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND449_RS11280	COG4574	serine-type endopeptidase inhibitor activity
ND449_RS11290	COG2246	polysaccharide biosynthetic process
ND449_RS11305	COG0814	amino acid
ND449_RS11330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ND449_RS11335	COG0596	Alpha beta hydrolase
ND449_RS11340	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ND449_RS11345	COG1169	isochorismate synthase
ND449_RS11350	COG4575	ribosome binding
ND449_RS11365	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_RS11370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ND449_RS11380	COG0839	Belongs to the complex I subunit 6 family
ND449_RS11385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_RS11390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ND449_RS11395	COG1034	ATP synthesis coupled electron transport
ND449_RS11415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_RS11420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ND449_RS11425	COG0583	DNA-binding transcription factor activity
ND449_RS11430	COG0436	Aminotransferase
ND449_RS11435	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
ND449_RS11440	COG0490	domain, Protein
ND449_RS11440	COG0471	metal ion transport
ND449_RS11450	COG3013	Belongs to the UPF0304 family
ND449_RS11455	COG3092	negative regulation of chromosome organization
ND449_RS11465	COG0857	belongs to the CobB CobQ family
ND449_RS11465	COG0280	phosphate acetyltransferase
ND449_RS11470	COG1609	Transcriptional regulator
ND449_RS11485	COG3037	sugar-specific permease SgaT UlaA
ND449_RS11490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ND449_RS11495	COG0622	Phosphoesterase
ND449_RS11510	COG0625	glutathione transferase activity
ND449_RS11515	COG1090	epimerase
ND449_RS11525	COG4160	amino acid transport
ND449_RS11530	COG4215	(ABC) transporter
ND449_RS11545	COG0163	prenyltransferase activity
ND449_RS11550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ND449_RS11555	COG1286	toxin biosynthetic process
ND449_RS11560	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
ND449_RS11565	COG0285	dihydrofolate synthase activity
ND449_RS11575	COG0586	Pfam SNARE associated Golgi protein
ND449_RS11585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ND449_RS11610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ND449_RS11615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND449_RS11645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ND449_RS11660	COG3101	peptidyl-lysine hydroxylation
ND449_RS11665	COG0730	response to heat
ND449_RS11670	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ND449_RS11680	COG2890	protein-(glutamine-N5) methyltransferase activity
ND449_RS11685	COG2840	Smr protein MutS2
ND449_RS11690	COG2062	phosphohistidine phosphatase, SixA
ND449_RS11695	COG1024	Enoyl-CoA hydratase
ND449_RS11695	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND449_RS11700	COG0183	Belongs to the thiolase family
ND449_RS11705	COG3691	Protein conserved in bacteria
ND449_RS11720	COG4235	cytochrome complex assembly
ND449_RS11720	COG3088	subunit of a heme lyase
ND449_RS11725	COG3088	subunit of a heme lyase
ND449_RS11725	COG4235	cytochrome complex assembly
ND449_RS11730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ND449_RS11735	COG1138	Cytochrome C-type biogenesis protein
ND449_RS11740	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ND449_RS11745	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND449_RS11750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND449_RS11755	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ND449_RS11770	COG0582	viral genome integration into host DNA
ND449_RS11775	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ND449_RS11830	COG2824	Alkylphosphonate utilization operon protein PhnA
ND449_RS11835	COG2951	lytic endotransglycosylase activity
ND449_RS11840	COG1598	PFAM Uncharacterised protein family UPF0150
ND449_RS11850	COG3038	cytochrome b561
ND449_RS11855	COG0436	Aminotransferase
ND449_RS11865	COG3275	phosphorelay sensor kinase activity
ND449_RS11870	COG3279	Response regulator of the LytR AlgR family
ND449_RS11875	COG2223	nitrite transmembrane transporter activity
ND449_RS11880	COG0837	glucose binding
ND449_RS11900	COG1914	H( )-stimulated, divalent metal cation uptake system
ND449_RS11905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND449_RS11975	COG3530	Putative quorum-sensing-regulated virulence factor
ND449_RS11980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND449_RS11990	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ND449_RS12000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_RS12015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ND449_RS12025	COG4208	sulfate ABC transporter
ND449_RS12030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ND449_RS12035	COG4150	thiosulfate binding
ND449_RS12045	COG1737	Transcriptional regulator
ND449_RS12050	COG2731	YhcH YjgK YiaL family protein
ND449_RS12065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND449_RS12070	COG2837	iron assimilation
ND449_RS12080	COG3111	PFAM Bacterial OB fold (BOF) protein
ND449_RS12140	COG1671	Belongs to the UPF0178 family
ND449_RS12145	COG0280	phosphate acetyltransferase
ND449_RS12145	COG0281	malic enzyme
ND449_RS12150	COG0494	nUDIX hydrolase
ND449_RS12155	COG3005	denitrification pathway
ND449_RS12160	COG3043	anaerobic respiration
ND449_RS12165	COG0243	molybdopterin cofactor binding
ND449_RS12170	COG3062	negative regulation of establishment of protein localization
ND449_RS12175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_RS12175	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_RS12180	COG2197	response regulator
ND449_RS12190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_RS12200	COG1605	Chorismate mutase
ND449_RS12205	COG1393	Belongs to the ArsC family
ND449_RS12210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ND449_RS12215	COG1876	peptidase activity
ND449_RS12225	COG0400	carboxylic ester hydrolase activity
ND449_RS12245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ND449_RS12250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ND449_RS12255	COG2716	regulation of RNA biosynthetic process
ND449_RS12260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ND449_RS12265	COG0628	permease
ND449_RS12270	COG4783	chaperone-mediated protein folding
ND449_RS12275	COG1393	Belongs to the ArsC family
ND449_RS12280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ND449_RS12285	COG2233	PERMEase
ND449_RS12290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ND449_RS12295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ND449_RS12300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ND449_RS12305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_RS12315	COG0581	inorganic phosphate transmembrane transporter activity
ND449_RS12320	COG0573	inorganic phosphate transmembrane transporter activity
ND449_RS12325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ND449_RS12340	COG2239	Acts as a magnesium transporter
ND449_RS12345	COG0443	Heat shock 70 kDa protein
ND449_RS12355	COG3121	Chaperone
ND449_RS12375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ND449_RS12385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ND449_RS12390	COG0477	Major facilitator Superfamily
ND449_RS12395	COG2205	protein histidine kinase activity
ND449_RS12400	COG0745	RESPONSE REGULATOR receiver
ND449_RS12405	COG3422	double-strand break repair
ND449_RS12410	COG0826	peptidase U32
ND449_RS12415	COG1597	lipid kinase activity
ND449_RS12430	COG0351	phosphomethylpyrimidine kinase
ND449_RS12445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ND449_RS12445	COG0519	Catalyzes the synthesis of GMP from XMP
ND449_RS12450	COG0517	IMP dehydrogenase activity
ND449_RS12450	COG0516	GMP reductase activity
ND449_RS12455	COG1570	exodeoxyribonuclease VII activity
ND449_RS12460	COG1645	bacterial-type flagellum-dependent swarming motility
ND449_RS12470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND449_RS12475	COG2976	Protein conserved in bacteria
ND449_RS12480	COG0124	histidyl-tRNA synthetase
ND449_RS12500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ND449_RS12515	COG4953	penicillin-binding protein 1C
ND449_RS12520	COG2373	Large extracellular alpha-helical protein
ND449_RS12535	COG2975	iron-sulfur cluster assembly
ND449_RS12540	COG0633	Ferredoxin
ND449_RS12545	COG0443	Heat shock 70 kDa protein
ND449_RS12560	COG0822	iron-sulfur transferase activity
ND449_RS12570	COG1959	2 iron, 2 sulfur cluster binding
ND449_RS12575	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ND449_RS12585	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ND449_RS12590	COG3683	transport system, periplasmic component
ND449_RS12595	COG3711	transcriptional antiterminator
ND449_RS12600	COG2814	Major facilitator Superfamily
ND449_RS12610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ND449_RS12610	COG1017	nitric oxide dioxygenase activity
ND449_RS12615	COG2188	Transcriptional regulator
ND449_RS12625	COG3457	Alanine racemase
ND449_RS12630	COG1735	metal-dependent hydrolase with the TIM-barrel fold
ND449_RS12645	COG0347	Belongs to the P(II) protein family
ND449_RS12650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_RS12650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ND449_RS12655	COG2204	response regulator
ND449_RS12660	COG3170	Tfp pilus assembly protein FimV
ND449_RS12665	COG2205	protein histidine kinase activity
ND449_RS12680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ND449_RS12690	COG0560	Phosphoserine phosphatase
ND449_RS12695	COG1263	PTS System
ND449_RS12695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_RS12705	COG1737	Transcriptional regulator
ND449_RS12710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ND449_RS12720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ND449_RS12730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ND449_RS12745	COG0481	GTPase activity
ND449_RS12750	COG3086	response to oxidative stress
ND449_RS12760	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ND449_RS12770	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ND449_RS12780	COG0513	Belongs to the DEAD box helicase family
ND449_RS12795	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
ND449_RS12805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ND449_RS12810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ND449_RS12815	COG0497	DNA recombination
ND449_RS12820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ND449_RS12830	COG2867	negative regulation of translational initiation
ND449_RS12835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ND449_RS12845	COG0582	viral genome integration into host DNA
ND449_RS12875	COG3596	GTP binding
ND449_RS12880	COG2378	regulation of single-species biofilm formation
ND449_RS12890	COG2378	regulation of single-species biofilm formation
ND449_RS12915	COG2003	Belongs to the UPF0758 family
ND449_RS12970	COG3121	Chaperone
ND449_RS12975	COG3188	usher protein
ND449_RS13000	COG0583	DNA-binding transcription factor activity
ND449_RS13075	COG1069	ribulokinase activity
ND449_RS13085	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND449_RS13090	COG1129	ABC transporter
ND449_RS13110	COG1620	l-lactate permease
ND449_RS13115	COG1304	FMN binding
ND449_RS13120	COG0579	oxidoreductase
ND449_RS13125	COG1278	Cold shock
ND449_RS13155	COG1780	Probably involved in ribonucleotide reductase function
ND449_RS13160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ND449_RS13170	COG4175	Glycine betaine
ND449_RS13175	COG4176	ABC-type proline glycine betaine transport system permease component
ND449_RS13180	COG2113	Glycine betaine
ND449_RS13190	COG2814	Major facilitator Superfamily
ND449_RS13195	COG1846	Transcriptional regulator
ND449_RS13205	COG1566	PFAM secretion protein HlyD family protein
ND449_RS13210	COG2814	Major facilitator Superfamily
ND449_RS13215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND449_RS13220	COG3118	belongs to the thioredoxin family
ND449_RS13225	COG3148	PFAM DTW domain containing protein
ND449_RS13230	COG0045	succinate-CoA ligase (ADP-forming) activity
ND449_RS13230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ND449_RS13230	COG1042	CoA-binding domain protein
ND449_RS13235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ND449_RS13240	COG5544	Lipoprotein
ND449_RS13265	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ND449_RS13275	COG2011	ABC-type metal ion transport system permease component
ND449_RS13280	COG1464	Belongs to the NlpA lipoprotein family
ND449_RS13290	COG1720	tRNA m6t6A37 methyltransferase activity
ND449_RS13295	COG0442	prolyl-tRNA aminoacylation
ND449_RS13300	COG3015	lipoprotein NlpE involved in copper resistance
ND449_RS13310	COG4681	YaeQ
ND449_RS13320	COG4568	rho-dependent transcription termination
ND449_RS13335	COG0346	lactoylglutathione lyase activity
ND449_RS13350	COG0825	malonyl-CoA metabolic process
ND449_RS13355	COG0587	DNA-directed DNA polymerase activity
ND449_RS13360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ND449_RS13380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ND449_RS13385	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ND449_RS13395	COG0750	zinc metalloprotease
ND449_RS13400	COG0575	Belongs to the CDS family
ND449_RS13420	COG0528	UMP kinase activity
ND449_RS13425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ND449_RS13440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ND449_RS13445	COG2171	N-acyltransferase activity
ND449_RS13460	COG0564	pseudouridine synthase activity
ND449_RS13465	COG3098	single-species biofilm formation
ND449_RS13480	COG1611	Belongs to the LOG family
ND449_RS13490	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ND449_RS13495	COG2363	Small membrane protein
ND449_RS13500	COG0583	DNA-binding transcription factor activity
ND449_RS13510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ND449_RS13515	COG2166	iron-sulfur cluster assembly
ND449_RS13520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ND449_RS13525	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ND449_RS13545	COG0860	N-Acetylmuramoyl-L-alanine amidase
ND449_RS13550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND449_RS13550	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ND449_RS13555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ND449_RS13560	COG1074	ATP-dependent DNA helicase activity
ND449_RS13565	COG1025	Belongs to the peptidase M16 family
ND449_RS13570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ND449_RS13575	COG4967	type IV pilus modification protein PilV
ND449_RS13600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ND449_RS13605	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
ND449_RS13615	COG3066	DNA modification
ND449_RS13620	COG0861	Integral membrane protein TerC family
ND449_RS13625	COG0667	Aldo Keto reductase
ND449_RS13630	COG0477	Major facilitator Superfamily
ND449_RS13635	COG0204	Acyl-transferase
ND449_RS13635	COG0318	PFAM AMP-dependent synthetase and ligase
ND449_RS13645	COG1609	Transcriptional regulator
ND449_RS13655	COG0583	DNA-binding transcription factor activity
ND449_RS13660	COG0583	DNA-binding transcription factor activity
ND449_RS13715	COG2165	general secretion pathway protein
ND449_RS13725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_RS13755	COG1127	ABC transporter
ND449_RS13760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND449_RS13770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ND449_RS13780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ND449_RS13785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND449_RS13790	COG4974	Belongs to the 'phage' integrase family
ND449_RS13795	COG0716	FMN binding
ND449_RS13805	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ND449_RS13815	COG1272	protein, Hemolysin III
ND449_RS13835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ND449_RS13840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND449_RS13845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ND449_RS13850	COG0006	proline dipeptidase activity
ND449_RS13860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ND449_RS13870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ND449_RS13875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ND449_RS13880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ND449_RS13895	COG1279	arginine transmembrane transporter activity
ND449_RS13905	COG0191	fructose-bisphosphate aldolase activity
ND449_RS13910	COG0126	phosphoglycerate kinase activity
ND449_RS13915	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ND449_RS13920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ND449_RS13935	COG1166	arginine decarboxylase activity
ND449_RS13940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ND449_RS13955	COG0640	Transcriptional regulator
ND449_RS13960	COG3091	SprT-like family
ND449_RS13965	COG2356	endonuclease I
ND449_RS13970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ND449_RS13975	COG0189	ligase activity
ND449_RS13980	COG1678	Uncharacterized ACR, COG1678
ND449_RS13985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ND449_RS13990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_RS14000	COG2805	Type II/IV secretion system protein
ND449_RS14005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ND449_RS14010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ND449_RS14015	COG0762	integral membrane protein
ND449_RS14020	COG1872	DUF167
ND449_RS14025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ND449_RS14030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND449_RS14045	COG3171	Protein conserved in bacteria
ND449_RS14055	COG1194	a g-specific adenine glycosylase
ND449_RS14060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ND449_RS14065	COG0741	lytic transglycosylase activity
ND449_RS14105	COG1105	Belongs to the carbohydrate kinase PfkB family
ND449_RS14110	COG1882	Formate acetyltransferase
ND449_RS14115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ND449_RS14120	COG0814	amino acid
ND449_RS14135	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_RS14140	COG3433	isochorismatase activity
ND449_RS14140	COG1535	isochorismatase
ND449_RS14145	COG1021	2,3-dihydroxybenzoate-AMP ligase
ND449_RS14150	COG1169	isochorismate synthase
ND449_RS14155	COG4592	Periplasmic binding protein
ND449_RS14165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_RS14170	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ND449_RS14175	COG1120	ATPase activity
ND449_RS14185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ND449_RS14190	COG3251	PFAM MbtH domain protein
ND449_RS14200	COG4774	siderophore transport
ND449_RS14205	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ND449_RS14230	COG4964	Belongs to the GSP D family
ND449_RS14290	COG0848	biopolymer transport protein
ND449_RS14295	COG0811	peptide transport
ND449_RS14300	COG0626	cystathionine gamma-synthase activity
ND449_RS14305	COG0586	Pfam SNARE associated Golgi protein
ND449_RS14310	COG2207	Transcriptional regulator
ND449_RS14315	COG1979	alcohol dehydrogenase
ND449_RS14320	COG0656	L-ascorbic acid biosynthetic process
ND449_RS14330	COG2132	Multicopper oxidase
ND449_RS14345	COG2249	NAD(P)H dehydrogenase (quinone) activity
ND449_RS14350	COG0583	DNA-binding transcription factor activity
ND449_RS14355	COG0187	DNA topoisomerase II activity
ND449_RS14360	COG3150	esterase
ND449_RS14365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ND449_RS14370	COG3151	Protein conserved in bacteria
ND449_RS14375	COG0494	nUDIX hydrolase
ND449_RS14380	COG1538	Outer membrane efflux protein
ND449_RS14385	COG5463	Belongs to the UPF0441 family
ND449_RS14390	COG0754	glutathionylspermidine amidase activity
ND449_RS14395	COG3384	dioxygenase
ND449_RS14400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ND449_RS14415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ND449_RS14415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ND449_RS14425	COG3025	triphosphatase activity
ND449_RS14430	COG4991	sh3 domain protein
ND449_RS14435	COG0617	tRNA 3'-terminal CCA addition
ND449_RS14440	COG1968	undecaprenyl-diphosphatase activity
ND449_RS14445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ND449_RS14450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ND449_RS14455	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ND449_RS14460	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ND449_RS14465	COG0358	DNA primase activity
ND449_RS14495	COG1028	Short-chain dehydrogenase reductase Sdr
ND449_RS14525	COG0463	Glycosyl transferase, family 2
ND449_RS14560	COG3210	domain, Protein
ND449_RS14565	COG2831	hemolysin activation secretion protein
ND449_RS14570	COG1902	pentaerythritol trinitrate reductase activity
ND449_RS14570	COG0446	pyridine nucleotide-disulphide oxidoreductase
ND449_RS14585	COG1451	nucleotide metabolic process
ND449_RS14590	COG0673	inositol 2-dehydrogenase activity
ND449_RS14595	COG0861	Integral membrane protein TerC family
ND449_RS14600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ND449_RS14610	COG2721	sulfolactate sulfo-lyase activity
ND449_RS14625	COG2271	Major facilitator Superfamily
ND449_RS14640	COG0586	Pfam SNARE associated Golgi protein
ND449_RS14655	COG4575	ribosome binding
ND449_RS14660	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ND449_RS14670	COG2259	Doxx family
ND449_RS14675	COG0583	DNA-binding transcription factor activity
ND449_RS14680	COG1741	Belongs to the pirin family
ND449_RS14695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ND449_RS14710	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ND449_RS14715	COG2823	Periplasmic or secreted lipoprotein
ND449_RS14720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ND449_RS14725	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
ND449_RS14730	COG5002	protein histidine kinase activity
ND449_RS14730	COG2198	Histidine kinase
ND449_RS14730	COG0784	Response regulator, receiver
ND449_RS14735	COG1242	4 iron, 4 sulfur cluster binding
ND449_RS14740	COG0069	glutamate synthase activity
ND449_RS14740	COG0067	glutamate synthase
ND449_RS14740	COG0070	glutamate synthase
ND449_RS14745	COG0493	'glutamate synthase
ND449_RS14755	COG2969	positive regulation of protein catabolic process
ND449_RS14760	COG0625	glutathione transferase activity
ND449_RS14765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ND449_RS14770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ND449_RS14775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ND449_RS14780	COG3105	Protein conserved in bacteria
ND449_RS14785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ND449_RS14795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ND449_RS14800	COG5007	Belongs to the BolA IbaG family
ND449_RS14805	COG3113	response to antibiotic
ND449_RS14810	COG2854	intermembrane phospholipid transfer
ND449_RS14815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ND449_RS14820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ND449_RS14825	COG1127	ABC transporter
ND449_RS14830	COG0530	calcium, potassium:sodium antiporter activity
ND449_RS14835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ND449_RS14835	COG0517	IMP dehydrogenase activity
ND449_RS14840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ND449_RS14845	COG3117	lipopolysaccharide transmembrane transporter activity
ND449_RS14850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ND449_RS14855	COG1137	ATPase activity
ND449_RS14860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ND449_RS14880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ND449_RS14885	COG0540	Belongs to the ATCase OTCase family
ND449_RS14890	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ND449_RS14900	COG0366	Alpha amylase catalytic
ND449_RS14905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ND449_RS14905	COG1263	PTS System
ND449_RS14915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ND449_RS14925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ND449_RS14930	COG3783	Cytochrome b(562)
ND449_RS14935	COG0312	modulator of DNA gyrase
ND449_RS14940	COG3028	Belongs to the UPF0307 family
ND449_RS14945	COG2732	(Barnase) inhibitor
ND449_RS14950	COG4290	ribonuclease
ND449_RS14960	COG1289	transmembrane transporter activity
ND449_RS14965	COG1566	PFAM secretion protein HlyD family protein
ND449_RS14975	COG0583	DNA-binding transcription factor activity
ND449_RS14980	COG0312	modulator of DNA gyrase
ND449_RS14985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ND449_RS14990	COG3164	Protein of unknown function
ND449_RS15000	COG0424	maF-like protein
ND449_RS15005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ND449_RS15010	COG1792	Involved in formation and maintenance of cell shape
ND449_RS15015	COG1077	Cell shape determining protein MreB Mrl
ND449_RS15020	COG2200	EAL domain
ND449_RS15020	COG2199	diguanylate cyclase activity
ND449_RS15025	COG0604	alcohol dehydrogenase
ND449_RS15030	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ND449_RS15035	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ND449_RS15045	COG0511	ligase activity, forming carbon-carbon bonds
ND449_RS15050	COG0439	Biotin carboxylase
ND449_RS15055	COG3924	membrane
ND449_RS15060	COG4145	pantothenate transmembrane transporter activity
ND449_RS15065	COG2264	protein methyltransferase activity
ND449_RS15070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND449_RS15075	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ND449_RS15085	COG1560	Kdo2-lipid A biosynthetic process
ND449_RS15095	COG1346	cytolysis
ND449_RS15100	COG1380	Effector of murein hydrolase LrgA
ND449_RS15105	COG0583	DNA-binding transcription factor activity
ND449_RS15110	COG0025	NhaP-type Na H and K H
ND449_RS15115	COG2252	PERMEase
ND449_RS15130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ND449_RS15135	COG2315	Protein conserved in bacteria
ND449_RS15140	COG1448	Aminotransferase
ND449_RS15165	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ND449_RS15170	COG0735	belongs to the Fur family
ND449_RS15175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ND449_RS15180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ND449_RS15185	COG2937	Belongs to the GPAT DAPAT family
ND449_RS15205	COG4580	involved in the transport of maltose and maltodextrins
ND449_RS15220	COG2182	Extracellular solute-binding protein
ND449_RS15225	COG1175	transmembrane transport
ND449_RS15230	COG3833	ABC-type maltose transport systems, permease component
ND449_RS15235	COG3223	Belongs to the PsiE family
ND449_RS15245	COG0527	aspartate kinase activity
ND449_RS15260	COG3328	transposase activity
ND449_RS15270	COG3328	transposase activity
ND449_RS15280	COG3328	transposase activity
ND449_RS15305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ND449_RS15385	COG0583	DNA-binding transcription factor activity
ND449_RS15425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ND449_RS15465	COG0138	bifunctional purine biosynthesis protein purh
ND449_RS15470	COG0151	Belongs to the GarS family
ND449_RS15490	COG1515	deoxyribonuclease V activity
ND449_RS15495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ND449_RS15500	COG2816	NAD+ diphosphatase activity
ND449_RS15505	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
ND449_RS15520	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ND449_RS15525	COG2104	thiamine diphosphate biosynthetic process
ND449_RS15530	COG2022	thiamine diphosphate biosynthetic process
ND449_RS15540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ND449_RS15545	COG0085	RNA polymerase activity
ND449_RS15550	COG0222	ribosome binding
ND449_RS15555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ND449_RS15565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ND449_RS15570	COG0250	Participates in transcription elongation, termination and antitermination
ND449_RS15615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ND449_RS15640	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ND449_RS15645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ND449_RS15650	COG1739	Uncharacterized protein family UPF0029
ND449_RS15660	COG1024	Enoyl-CoA hydratase
ND449_RS15660	COG1250	3-hydroxyacyl-CoA dehydrogenase
ND449_RS15670	COG0543	2 iron, 2 sulfur cluster binding
ND449_RS15685	COG0250	Participates in transcription elongation, termination and antitermination
ND449_RS15700	COG0805	protein transport
ND449_RS15705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND449_RS15710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ND449_RS15715	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ND449_RS15720	COG3165	ubiquinone biosynthetic process from chorismate
ND449_RS15725	COG2226	methyltransferase
ND449_RS15730	COG1322	Protein conserved in bacteria
ND449_RS15735	COG0586	Pfam SNARE associated Golgi protein
ND449_RS15740	COG1966	Carbon starvation protein
ND449_RS15755	COG0412	Dienelactone hydrolase
ND449_RS15760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ND449_RS15765	COG0583	DNA-binding transcription factor activity
ND449_RS15770	COG0697	spore germination
ND449_RS15780	COG0584	glycerophosphoryl diester phosphodiesterase
ND449_RS15790	COG0395	ABC-type sugar transport system, permease component
ND449_RS15795	COG1175	transmembrane transport
ND449_RS15800	COG1653	transport
ND449_RS15835	COG0410	ABC transporter
ND449_RS15845	COG4177	L-phenylalanine transmembrane transporter activity
ND449_RS15865	COG1929	Belongs to the glycerate kinase type-1 family
ND449_RS15870	COG2610	gluconate transmembrane transporter activity
ND449_RS15875	COG3835	regulator
ND449_RS15885	COG2177	Part of the ABC transporter FtsEX involved in
ND449_RS15890	COG2884	Cell division ATP-binding protein ftsE
ND449_RS15895	COG0552	protein localization to endoplasmic reticulum
ND449_RS15895	COG0552	protein localization to endoplasmic reticulum
ND449_RS15900	COG0742	ribosomal rna small subunit methyltransferase
ND449_RS15905	COG3776	membrane
ND449_RS15920	COG3714	YhhN family
ND449_RS15935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ND449_RS15945	COG0247	lactate metabolic process
ND449_RS15955	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ND449_RS15965	COG2271	Major facilitator Superfamily
ND449_RS15970	COG0584	glycerophosphoryl diester phosphodiesterase
ND449_RS15975	COG0561	phosphatase activity
ND449_RS15980	COG2267	carboxylic ester hydrolase activity
ND449_RS15985	COG1280	lysine exporter protein (LysE YggA)
ND449_RS15990	COG0514	ATP-dependent DNA helicase (RecQ)
ND449_RS15995	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
ND449_RS16000	COG2050	protein possibly involved in aromatic compounds catabolism
ND449_RS16020	COG5564	TIM-barrel signal transduction protein
ND449_RS16025	COG5441	Belongs to the UPF0261 family
ND449_RS16035	COG0210	DNA helicase
ND449_RS16040	COG1011	Hydrolase
ND449_RS16045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ND449_RS16050	COG3159	Protein conserved in bacteria
ND449_RS16055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ND449_RS16060	COG5567	small periplasmic lipoprotein
ND449_RS16070	COG3072	Adenylate cyclase
ND449_RS16075	COG0181	hydroxymethylbilane synthase activity
ND449_RS16080	COG1587	Uroporphyrinogen-III synthase
ND449_RS16085	COG2959	enzyme of heme biosynthesis
ND449_RS16090	COG3071	HemY protein
ND449_RS16140	COG2244	polysaccharide biosynthetic process
ND449_RS16145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ND449_RS16150	COG0456	acetyltransferase
ND449_RS16155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ND449_RS16160	COG1088	dTDP-glucose 4,6-dehydratase activity
ND449_RS16165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ND449_RS16170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ND449_RS16175	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
ND449_RS16180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ND449_RS16185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ND449_RS16190	COG3118	belongs to the thioredoxin family
ND449_RS16200	COG0248	Ppx GppA phosphatase
ND449_RS16210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ND449_RS16225	COG3397	chitin binding
ND449_RS16235	COG0129	dihydroxy-acid dehydratase activity
ND449_RS16245	COG3978	acetolactate synthase activity
ND449_RS16265	COG3085	chromosome segregation
ND449_RS16270	COG0583	DNA-binding transcription factor activity
ND449_RS16345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_RS16355	COG0678	peroxiredoxin activity
ND449_RS16355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND449_RS16360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ND449_RS16395	COG1629	transport
ND449_RS16400	COG0165	Argininosuccinate lyase
ND449_RS16405	COG0137	argininosuccinate synthase activity
ND449_RS16410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ND449_RS16455	COG0527	aspartate kinase activity
ND449_RS16455	COG0460	homoserine dehydrogenase
ND449_RS16460	COG0626	cystathionine gamma-synthase activity
ND449_RS16465	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ND449_RS16475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ND449_RS16480	COG1609	Transcriptional regulator
ND449_RS16485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ND449_RS16490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ND449_RS16495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ND449_RS16500	COG1575	Belongs to the MenA family. Type 1 subfamily
ND449_RS16505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ND449_RS16510	COG3074	FtsZ-dependent cytokinesis
ND449_RS16515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ND449_RS16520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ND449_RS16525	COG1494	fructose-1,6-bisphosphatase
ND449_RS16530	COG2814	Major facilitator Superfamily
ND449_RS16540	COG3152	Membrane
ND449_RS16555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ND449_RS16565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ND449_RS16570	COG3678	ATP-independent chaperone mediated protein folding
ND449_RS16575	COG0745	RESPONSE REGULATOR receiver
ND449_RS16580	COG2205	protein histidine kinase activity
ND449_RS16585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ND449_RS16590	COG1045	serine acetyltransferase
ND449_RS16595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ND449_RS16600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ND449_RS16605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ND449_RS16610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ND449_RS16615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ND449_RS16620	COG4942	peptidase
ND449_RS16625	COG2861	carbohydrate metabolic process
ND449_RS16640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ND449_RS16645	COG0859	PFAM glycosyl transferase family 9
ND449_RS16650	COG0859	PFAM glycosyl transferase family 9
ND449_RS16655	COG1519	Transferase
ND449_RS16675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ND449_RS16680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ND449_RS16685	COG2003	Belongs to the UPF0758 family
ND449_RS16690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ND449_RS16695	COG0756	dUTP diphosphatase activity
ND449_RS16700	COG1309	transcriptional regulator
ND449_RS16705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ND449_RS16710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ND449_RS16715	COG1561	YicC-like family, N-terminal region
ND449_RS16730	COG5001	Diguanylate cyclase
ND449_RS16735	COG1024	Enoyl-CoA hydratase
ND449_RS16740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ND449_RS16750	COG2860	membrane
ND449_RS16755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ND449_RS16765	COG1758	RNA polymerase activity
ND449_RS16770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ND449_RS16775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ND449_RS16780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ND449_RS16785	COG0786	glutamate:sodium symporter activity
ND449_RS16790	COG2233	PERMEase
ND449_RS16795	COG2982	Protein involved in outer membrane biogenesis
ND449_RS16800	COG0456	acetyltransferase
ND449_RS16815	COG1011	Hydrolase
ND449_RS16830	COG3852	Histidine kinase
ND449_RS16840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ND449_RS16850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ND449_RS16855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND449_RS16855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ND449_RS16860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ND449_RS16865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ND449_RS16870	COG3084	Protein conserved in bacteria
ND449_RS16880	COG1763	Mo-molybdopterin cofactor biosynthetic process
ND449_RS16905	COG2186	Transcriptional regulator
ND449_RS16910	COG1609	Transcriptional regulator
ND449_RS16915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ND449_RS16925	COG1172	Belongs to the binding-protein-dependent transport system permease family
ND449_RS16930	COG1129	ABC transporter
ND449_RS16935	COG1869	D-ribose catabolic process
ND449_RS16940	COG3158	transport of potassium into the cell
ND449_RS16945	COG0714	Associated with various cellular activities
ND449_RS16950	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ND449_RS16960	COG2502	aspartate--ammonia ligase
ND449_RS16965	COG1522	sequence-specific DNA binding
ND449_RS16970	COG0716	FMN binding
ND449_RS16975	COG0445	tRNA wobble uridine modification
ND449_RS16980	COG0357	Ribosomal RNA small subunit methyltransferase G
ND449_RS16985	COG3312	ion transport
ND449_RS16990	COG0356	it plays a direct role in the translocation of protons across the membrane
ND449_RS17000	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ND449_RS17010	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ND449_RS17015	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ND449_RS17025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ND449_RS17040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ND449_RS17045	COG0573	inorganic phosphate transmembrane transporter activity
ND449_RS17050	COG0581	inorganic phosphate transmembrane transporter activity
ND449_RS17060	COG0704	Plays a role in the regulation of phosphate uptake
ND449_RS17065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ND449_RS17070	COG0765	amino acid transport
ND449_RS17075	COG0765	amino acid transport
ND449_RS17080	COG2252	PERMEase
ND449_RS17085	COG0840	transmembrane signaling receptor activity
ND449_RS17095	COG3121	Chaperone
ND449_RS17110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ND449_RS17115	COG0706	membrane insertase activity
ND449_RS17125	COG0594	ribonuclease P activity
ND449_RS17130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ND449_RS17195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ND449_RS17225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ND449_RS17240	COG3549	Plasmid maintenance system killer
ND449_RS17245	COG3093	addiction module antidote protein HigA
ND449_RS17620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ND449_RS17635	COG0741	lytic transglycosylase activity
ND449_RS17795	COG2944	sequence-specific DNA binding
ND449_RS17865	COG1192	Involved in chromosome partitioning
ND449_RS17940	COG1454	alcohol dehydrogenase