locus-tag	class	description
BD65_RS00010	COG0308	aminopeptidase N
BD65_RS00015	COG0167	dihydroorotate dehydrogenase activity
BD65_RS00025	COG0633	Ferredoxin
BD65_RS00025	COG3217	Mosc domain protein beta barrel domain protein
BD65_RS00030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD65_RS00030	COG0116	Belongs to the methyltransferase superfamily
BD65_RS00035	COG0488	(ABC) transporter
BD65_RS00040	COG2995	paraquat-inducible protein a
BD65_RS00045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BD65_RS00045	COG3008	intermembrane lipid transfer
BD65_RS00050	COG3009	Protein conserved in bacteria
BD65_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BD65_RS00060	COG1067	ATP-dependent peptidase activity
BD65_RS00065	COG3120	sequence-specific DNA binding
BD65_RS00075	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
BD65_RS00080	COG3070	regulator of competence-specific genes
BD65_RS00085	COG1289	transmembrane transporter activity
BD65_RS00090	COG3304	Inner membrane component domain
BD65_RS00095	COG0210	DNA helicase
BD65_RS00100	COG1803	Methylglyoxal synthase
BD65_RS00110	COG1832	CoA-binding protein
BD65_RS00115	COG3785	DNA binding
BD65_RS00120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BD65_RS00125	COG1254	Belongs to the acylphosphatase family
BD65_RS00130	COG2920	part of a sulfur-relay system
BD65_RS00140	COG0288	reversible hydration of carbon dioxide
BD65_RS00175	COG0675	Transposase, IS605 OrfB family
BD65_RS00190	COG1560	Kdo2-lipid A biosynthetic process
BD65_RS00200	COG0628	permease
BD65_RS00205	COG2197	response regulator
BD65_RS00225	COG0418	dihydroorotase activity
BD65_RS00230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BD65_RS00240	COG1530	ribonuclease E activity
BD65_RS00245	COG0564	pseudouridine synthase activity
BD65_RS00250	COG0424	maF-like protein
BD65_RS00255	COG1399	metal-binding, possibly nucleic acid-binding protein
BD65_RS00260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BD65_RS00270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BD65_RS00275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BD65_RS00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BD65_RS00290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BD65_RS00295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BD65_RS00300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BD65_RS00305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BD65_RS00310	COG0470	DNA polymerase III
BD65_RS00315	COG0084	hydrolase, TatD family'
BD65_RS00320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_RS00320	COG1263	PTS System
BD65_RS00325	COG0537	adenosine 5'-monophosphoramidase activity
BD65_RS00330	COG5633	Lipoprotein
BD65_RS00335	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
BD65_RS00350	COG3150	esterase
BD65_RS00355	COG1252	NADH dehydrogenase
BD65_RS00360	COG3134	Outer membrane lipoprotein
BD65_RS00365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BD65_RS00370	COG4591	ABC-type transport system involved in lipoprotein release permease component
BD65_RS00380	COG4591	ABC-type transport system involved in lipoprotein release permease component
BD65_RS00400	COG2850	peptidyl-arginine hydroxylation
BD65_RS00405	COG2205	protein histidine kinase activity
BD65_RS00410	COG0745	RESPONSE REGULATOR receiver
BD65_RS00420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BD65_RS00425	COG2915	High frequency lysogenization protein hflD homolog
BD65_RS00430	COG0482	sulfurtransferase activity
BD65_RS00440	COG1187	pseudouridine synthase activity
BD65_RS00445	COG0538	isocitrate dehydrogenase activity
BD65_RS00450	COG2771	luxR family
BD65_RS00455	COG3916	Acyl-homoserine-lactone synthase
BD65_RS00460	COG2723	6-phospho-beta-galactosidase activity
BD65_RS00465	COG0339	signal peptide processing
BD65_RS00470	COG3493	citrate carrier protein
BD65_RS00475	COG4565	transcriptional regulatory protein
BD65_RS00480	COG3290	protein histidine kinase activity
BD65_RS00485	COG0471	metal ion transport
BD65_RS00515	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
BD65_RS00520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BD65_RS00535	COG4977	sequence-specific DNA binding
BD65_RS00540	COG1702	phosphate starvation-inducible protein PhoH
BD65_RS00545	COG0387	Pfam Sodium calcium exchanger
BD65_RS00550	COG2375	cellular response to nickel ion
BD65_RS00555	COG3850	Histidine kinase
BD65_RS00560	COG1294	oxidase, subunit
BD65_RS00565	COG1271	oxidase subunit
BD65_RS00570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BD65_RS00575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BD65_RS00580	COG3138	arginine N-succinyltransferase
BD65_RS00590	COG3724	N-succinylarginine dihydrolase activity
BD65_RS00610	COG1228	amidohydrolase
BD65_RS00620	COG0402	S-adenosylhomocysteine deaminase activity
BD65_RS00660	COG0012	GTP binding
BD65_RS00670	COG0193	aminoacyl-tRNA hydrolase activity
BD65_RS00680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BD65_RS00690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BD65_RS00695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BD65_RS00700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BD65_RS00705	COG2890	protein-(glutamine-N5) methyltransferase activity
BD65_RS00720	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BD65_RS00725	COG0659	secondary active sulfate transmembrane transporter activity
BD65_RS00730	COG3706	GGDEF domain
BD65_RS00755	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BD65_RS00765	COG3381	protein complex oligomerization
BD65_RS00780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_RS00790	COG0673	inositol 2-dehydrogenase activity
BD65_RS00820	COG3102	Protein conserved in bacteria
BD65_RS00825	COG3142	Participates in the control of copper homeostasis
BD65_RS00840	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BD65_RS00845	COG1801	Protein of unknown function DUF72
BD65_RS00855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BD65_RS00860	COG0494	nUDIX hydrolase
BD65_RS00870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BD65_RS00880	COG2255	four-way junction helicase activity
BD65_RS00885	COG3104	oligopeptide transport
BD65_RS00890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BD65_RS00895	COG1121	(ABC) transporter
BD65_RS00900	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BD65_RS00905	COG0739	heme binding
BD65_RS00910	COG1560	Kdo2-lipid A biosynthetic process
BD65_RS00915	COG0469	pyruvate kinase activity
BD65_RS00920	COG1737	Transcriptional regulator
BD65_RS00925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BD65_RS00930	COG0800	Aldolase
BD65_RS00940	COG2076	Multidrug Resistance protein
BD65_RS00945	COG0251	oxidation-reduction process
BD65_RS00950	COG1199	ATP-dependent helicase activity
BD65_RS00955	COG1214	PFAM Peptidase M22, glycoprotease
BD65_RS00960	COG3065	identical protein binding
BD65_RS00965	COG0318	PFAM AMP-dependent synthetase and ligase
BD65_RS00970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BD65_RS00975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BD65_RS00980	COG2894	cell division
BD65_RS00985	COG0850	regulation of cytokinetic process
BD65_RS00990	COG3100	YcgL domain-containing protein
BD65_RS00995	COG0179	Fumarylacetoacetate (FAA) hydrolase
BD65_RS01000	COG2983	Belongs to the UPF0260 family
BD65_RS01015	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BD65_RS01025	COG2719	SpoVR family
BD65_RS01030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BD65_RS01035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BD65_RS01040	COG2814	Major facilitator Superfamily
BD65_RS01050	COG2202	Pas domain
BD65_RS01050	COG2200	EAL domain
BD65_RS01050	COG2199	diguanylate cyclase activity
BD65_RS01070	COG0675	Transposase, IS605 OrfB family
BD65_RS01075	COG2718	Belongs to the UPF0229 family
BD65_RS01080	COG2766	serine protein kinase
BD65_RS01085	COG3713	MltA-interacting MipA family protein
BD65_RS01090	COG2194	sulfuric ester hydrolase activity
BD65_RS01105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD65_RS01110	COG3139	Protein of unknown function (DUF1315)
BD65_RS01115	COG1335	isochorismatase
BD65_RS01120	COG0252	asparaginase activity
BD65_RS01125	COG0616	signal peptide processing
BD65_RS01130	COG0778	Nitroreductase
BD65_RS01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BD65_RS01150	COG0494	nUDIX hydrolase
BD65_RS01155	COG0708	Exodeoxyribonuclease III
BD65_RS01180	COG0788	formyltetrahydrofolate deformylase activity
BD65_RS01190	COG1752	Esterase of the alpha-beta hydrolase superfamily
BD65_RS01195	COG0745	RESPONSE REGULATOR receiver
BD65_RS01215	COG1012	belongs to the aldehyde dehydrogenase family
BD65_RS01215	COG1454	alcohol dehydrogenase
BD65_RS01220	COG2095	MarC family integral membrane protein
BD65_RS01225	COG4166	transmembrane transport
BD65_RS01240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD65_RS01255	COG3099	Belongs to the UPF0263 family
BD65_RS01260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD65_RS01280	COG2350	Protein conserved in bacteria
BD65_RS01295	COG3710	Transcriptional regulator
BD65_RS01335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BD65_RS01360	COG0727	PFAM Uncharacterised protein family (UPF0153)
BD65_RS01365	COG3047	cAMP biosynthetic process
BD65_RS01380	COG0133	tryptophan synthase activity
BD65_RS01385	COG0134	indole-3-glycerol-phosphate synthase activity
BD65_RS01385	COG0135	phosphoribosylanthranilate isomerase activity
BD65_RS01395	COG0512	Glutamine amidotransferase of anthranilate synthase
BD65_RS01405	COG0613	PHP domain protein
BD65_RS01410	COG0009	L-threonylcarbamoyladenylate synthase
BD65_RS01415	COG1187	pseudouridine synthase activity
BD65_RS01425	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_RS01430	COG0616	signal peptide processing
BD65_RS01445	COG0583	DNA-binding transcription factor activity
BD65_RS01460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BD65_RS01470	COG0671	phosphoesterase, PA-phosphatase related
BD65_RS01475	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BD65_RS01480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BD65_RS01500	COG0023	Translation Initiation Factor
BD65_RS01510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BD65_RS01515	COG3447	MASE1 domain protein
BD65_RS01515	COG5001	Diguanylate cyclase
BD65_RS01515	COG5002	protein histidine kinase activity
BD65_RS01520	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BD65_RS01525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BD65_RS01535	COG4659	FMN binding
BD65_RS01545	COG2207	Transcriptional regulator
BD65_RS01545	COG3708	Transcriptional regulator
BD65_RS01575	COG4657	Part of a membrane complex involved in electron transport
BD65_RS01585	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BD65_RS01595	COG0673	inositol 2-dehydrogenase activity
BD65_RS01600	COG0385	Bile acid
BD65_RS01605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BD65_RS01610	COG5339	Protein conserved in bacteria
BD65_RS01615	COG1482	cell wall glycoprotein biosynthetic process
BD65_RS01620	COG0114	fumarate hydratase activity
BD65_RS01630	COG1940	carbohydrate kinase activity
BD65_RS01635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BD65_RS01655	COG1742	UPF0060 membrane protein
BD65_RS01660	COG4221	oxidoreductase activity
BD65_RS01665	COG3023	N-Acetylmuramoyl-L-alanine amidase
BD65_RS01695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BD65_RS01725	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BD65_RS01745	COG1011	Hydrolase
BD65_RS01755	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BD65_RS01760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BD65_RS01765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD65_RS01770	COG0589	response to stress
BD65_RS01780	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BD65_RS01785	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BD65_RS01795	COG0531	amino acid
BD65_RS01810	COG0745	RESPONSE REGULATOR receiver
BD65_RS01815	COG2205	protein histidine kinase activity
BD65_RS01830	COG2207	Transcriptional regulator
BD65_RS01835	COG1881	PFAM PEBP family protein
BD65_RS01840	COG4571	Outer membrane protease
BD65_RS01850	COG3591	Belongs to the peptidase S1B family
BD65_RS01860	COG1643	Atp-dependent helicase
BD65_RS01865	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BD65_RS01870	COG3784	Protein of unknown function (DUF1318)
BD65_RS01885	COG2911	Protein conserved in bacteria
BD65_RS01890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BD65_RS01895	COG3187	Heat shock protein
BD65_RS01900	COG3042	response to heat
BD65_RS01905	COG1285	pathogenesis
BD65_RS01915	COG1013	pyruvate-flavodoxin oxidoreductase activity
BD65_RS01915	COG0674	pyruvate-flavodoxin oxidoreductase activity
BD65_RS01915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_RS01915	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BD65_RS01925	COG0598	Magnesium transport protein CorA
BD65_RS01930	COG4166	transmembrane transport
BD65_RS01935	COG2866	Carboxypeptidase
BD65_RS01940	COG4948	Mandelate Racemase Muconate Lactonizing
BD65_RS01945	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BD65_RS01955	COG5642	Protein of unknown function (DUF2384)
BD65_RS01960	COG5654	RES domain protein
BD65_RS01965	COG3768	UPF0283 membrane protein
BD65_RS01970	COG3106	COG3106 Predicted ATPase
BD65_RS01980	COG1983	PspC domain protein
BD65_RS01990	COG1842	Phage shock protein A
BD65_RS01995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BD65_RS02010	COG4166	transmembrane transport
BD65_RS02020	COG4171	peptide transport system, permease
BD65_RS02025	COG4172	Belongs to the ABC transporter superfamily
BD65_RS02030	COG4172	Belongs to the ABC transporter superfamily
BD65_RS02040	COG3104	oligopeptide transport
BD65_RS02050	COG0484	heat shock protein binding
BD65_RS02100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BD65_RS02105	COG3133	Outer membrane lipoprotein
BD65_RS02110	COG1846	Transcriptional regulator
BD65_RS02115	COG4989	oxidoreductase activity
BD65_RS02120	COG3313	Fe-S protein
BD65_RS02130	COG2194	sulfuric ester hydrolase activity
BD65_RS02135	COG1309	transcriptional regulator
BD65_RS02140	COG1902	pentaerythritol trinitrate reductase activity
BD65_RS02155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BD65_RS02160	COG0791	NLP P60 protein
BD65_RS02165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BD65_RS02170	COG1609	Transcriptional regulator
BD65_RS02175	COG0583	DNA-binding transcription factor activity
BD65_RS02180	COG2814	Major facilitator Superfamily
BD65_RS02185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BD65_RS02190	COG0307	riboflavin synthase, alpha
BD65_RS02195	COG0534	Mate efflux family protein
BD65_RS02230	COG1388	LysM domain
BD65_RS02230	COG1376	ErfK ybiS ycfS ynhG family protein
BD65_RS02235	COG2166	iron-sulfur cluster assembly
BD65_RS02245	COG0719	Fe-S assembly protein
BD65_RS02250	COG0396	ATPase activity
BD65_RS02255	COG0719	Fe-S assembly protein
BD65_RS02260	COG0316	Belongs to the HesB IscA family
BD65_RS02265	COG2050	protein possibly involved in aromatic compounds catabolism
BD65_RS02270	COG0277	FAD linked oxidase domain protein
BD65_RS02270	COG0247	lactate metabolic process
BD65_RS02275	COG0628	permease
BD65_RS02280	COG0574	Belongs to the PEP-utilizing enzyme family
BD65_RS02280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BD65_RS02285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BD65_RS02290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BD65_RS02295	COG4771	TonB-dependent receptor
BD65_RS02300	COG3720	iron ion transport
BD65_RS02305	COG4558	Periplasmic binding protein
BD65_RS02310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_RS02315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BD65_RS02325	COG0095	Lipoate-protein ligase
BD65_RS02330	COG0791	NLP P60 protein
BD65_RS02335	COG2076	Multidrug Resistance protein
BD65_RS02340	COG2076	Multidrug Resistance protein
BD65_RS02345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BD65_RS02360	COG0463	Glycosyl transferase, family 2
BD65_RS02365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BD65_RS02375	COG4139	cobalamin transport
BD65_RS02385	COG4974	Belongs to the 'phage' integrase family
BD65_RS02410	COG0776	regulation of translation
BD65_RS02485	COG0803	Belongs to the bacterial solute-binding protein 9 family
BD65_RS02490	COG1121	(ABC) transporter
BD65_RS02495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BD65_RS02500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BD65_RS02505	COG3001	Fructosamine kinase
BD65_RS02515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BD65_RS02520	COG1988	membrane-bound metal-dependent
BD65_RS02525	COG1823	symporter activity
BD65_RS02530	COG3023	N-Acetylmuramoyl-L-alanine amidase
BD65_RS02540	COG2814	Major facilitator Superfamily
BD65_RS02545	COG0501	Belongs to the peptidase M48B family
BD65_RS02550	COG0793	Belongs to the peptidase S41A family
BD65_RS02560	COG1956	GAF domain-containing protein
BD65_RS02565	COG2995	paraquat-inducible protein a
BD65_RS02570	COG3008	intermembrane lipid transfer
BD65_RS02575	COG5001	Diguanylate cyclase
BD65_RS02575	COG2203	Gaf domain
BD65_RS02575	COG4251	negative regulation of phosphorylation
BD65_RS02575	COG3706	GGDEF domain
BD65_RS02655	COG1276	copper resistance
BD65_RS02660	COG2372	response to copper ion
BD65_RS02665	COG1528	Iron-storage protein
BD65_RS02680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BD65_RS02685	COG1770	oligopeptidase
BD65_RS02695	COG3097	Belongs to the UPF0267 family
BD65_RS02700	COG3141	response to X-ray
BD65_RS02705	COG0513	Belongs to the DEAD box helicase family
BD65_RS02730	COG0494	nUDIX hydrolase
BD65_RS02735	COG1760	l-serine dehydratase
BD65_RS02745	COG1253	flavin adenine dinucleotide binding
BD65_RS02750	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_RS02750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_RS02755	COG3715	PTS system
BD65_RS02760	COG3716	PTS system mannose fructose sorbose family IID component
BD65_RS02765	COG4811	Protein of unknown function (DUF986)
BD65_RS02770	COG1971	Probably functions as a manganese efflux pump
BD65_RS02790	COG1960	acyl-CoA dehydrogenase activity
BD65_RS02800	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BD65_RS02830	COG2226	methyltransferase
BD65_RS02835	COG0768	penicillin binding
BD65_RS02840	COG1496	oxidoreductase activity
BD65_RS02855	COG1113	amino acid transport
BD65_RS02890	COG2207	Transcriptional regulator
BD65_RS02905	COG1132	(ABC) transporter
BD65_RS02915	COG4251	negative regulation of phosphorylation
BD65_RS02915	COG3706	GGDEF domain
BD65_RS02915	COG5001	Diguanylate cyclase
BD65_RS02915	COG2203	Gaf domain
BD65_RS02935	COG1181	Belongs to the D-alanine--D-alanine ligase family
BD65_RS02955	COG1278	Cold shock
BD65_RS02970	COG2169	Transcriptional regulator
BD65_RS02970	COG1917	Cupin 2, conserved barrel domain protein
BD65_RS02975	COG1447	Phosphotransferase system cellobiose-specific component IIA
BD65_RS02980	COG2723	6-phospho-beta-galactosidase activity
BD65_RS02985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BD65_RS02990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BD65_RS03000	COG1187	pseudouridine synthase activity
BD65_RS03005	COG3122	Protein conserved in bacteria
BD65_RS03010	COG1757	Na H antiporter
BD65_RS03025	COG2235	arginine
BD65_RS03040	COG0076	glutamate decarboxylase activity
BD65_RS03045	COG0531	amino acid
BD65_RS03080	COG2153	protein acetylation
BD65_RS03090	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BD65_RS03130	COG0840	transmembrane signaling receptor activity
BD65_RS03160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BD65_RS03165	COG0322	excinuclease ABC activity
BD65_RS03170	COG2197	response regulator
BD65_RS03190	COG1113	amino acid transport
BD65_RS03200	COG0531	amino acid
BD65_RS03205	COG3710	Transcriptional regulator
BD65_RS03210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BD65_RS03215	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BD65_RS03215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BD65_RS03215	COG0506	proline dehydrogenase activity
BD65_RS03220	COG1126	abc transporter atp-binding protein
BD65_RS03225	COG0765	amino acid transport
BD65_RS03230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_RS03235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BD65_RS03245	COG1191	sigma factor activity
BD65_RS03285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BD65_RS03290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BD65_RS03300	COG1677	Flagellar hook-basal body complex protein FliE
BD65_RS03310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BD65_RS03320	COG1157	protein secretion by the type III secretion system
BD65_RS03335	COG1580	Controls the rotational direction of flagella during chemotaxis
BD65_RS03405	COG1749	Flagellar hook protein flgE
BD65_RS03415	COG1558	bacterial-type flagellum-dependent cell motility
BD65_RS03420	COG1815	bacterial-type flagellum-dependent cell motility
BD65_RS03430	COG2747	anti-sigma28 factor FlgM
BD65_RS03435	COG3418	PFAM FlgN family protein
BD65_RS03445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BD65_RS03450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BD65_RS03455	COG4935	Belongs to the peptidase S8 family
BD65_RS03455	COG1404	Belongs to the peptidase S8 family
BD65_RS03460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BD65_RS03465	COG0745	RESPONSE REGULATOR receiver
BD65_RS03475	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BD65_RS03480	COG0840	transmembrane signaling receptor activity
BD65_RS03485	COG0840	transmembrane signaling receptor activity
BD65_RS03490	COG0835	chemotaxis
BD65_RS03495	COG2198	Histidine kinase
BD65_RS03495	COG0643	Histidine kinase
BD65_RS03500	COG1360	Flagellar Motor Protein
BD65_RS03525	COG0589	response to stress
BD65_RS03530	COG1285	pathogenesis
BD65_RS03535	COG0840	transmembrane signaling receptor activity
BD65_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_RS03560	COG0604	alcohol dehydrogenase
BD65_RS03560	COG3321	synthase
BD65_RS03610	COG0471	metal ion transport
BD65_RS03625	COG3051	citrate lyase alpha subunit
BD65_RS03630	COG2301	Belongs to the HpcH HpaI aldolase family
BD65_RS03635	COG3052	prosthetic group binding
BD65_RS03640	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BD65_RS03645	COG3290	protein histidine kinase activity
BD65_RS03650	COG4565	transcriptional regulatory protein
BD65_RS03665	COG2271	Major facilitator Superfamily
BD65_RS03670	COG1840	ABC-type Fe3 transport system, periplasmic component
BD65_RS03680	COG3842	ATPase activity
BD65_RS03700	COG1289	transmembrane transporter activity
BD65_RS03710	COG2925	Exonuclease
BD65_RS03715	COG0531	amino acid
BD65_RS03720	COG4771	TonB-dependent receptor
BD65_RS03730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_RS03740	COG0833	amino acid
BD65_RS03755	COG0675	Transposase, IS605 OrfB family
BD65_RS03760	COG2855	membrane
BD65_RS03765	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BD65_RS03770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BD65_RS03770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BD65_RS03770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BD65_RS03775	COG1105	Belongs to the carbohydrate kinase PfkB family
BD65_RS03790	COG3005	denitrification pathway
BD65_RS03795	COG0243	molybdopterin cofactor binding
BD65_RS03810	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BD65_RS03820	COG0246	Mannitol dehydrogenase
BD65_RS03830	COG0523	cobalamin synthesis protein
BD65_RS03835	COG0671	phosphoesterase, PA-phosphatase related
BD65_RS03840	COG0791	NLP P60 protein
BD65_RS03845	COG2200	EAL domain
BD65_RS03850	COG4166	transmembrane transport
BD65_RS03855	COG4174	ABC transporter (Permease)
BD65_RS03860	COG4239	(ABC) transporter, permease
BD65_RS03865	COG4172	Belongs to the ABC transporter superfamily
BD65_RS03875	COG2814	Major facilitator Superfamily
BD65_RS03880	COG1187	pseudouridine synthase activity
BD65_RS03885	COG1061	Type III restriction enzyme res subunit
BD65_RS03900	COG3082	Protein of unknown function (DUF1414)
BD65_RS03905	COG3083	sulfuric ester hydrolase activity
BD65_RS03920	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BD65_RS03945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BD65_RS03950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_RS03980	COG2223	nitrite transmembrane transporter activity
BD65_RS03985	COG2198	Histidine kinase
BD65_RS03985	COG0642	Histidine kinase
BD65_RS03995	COG0784	Response regulator, receiver
BD65_RS03995	COG2205	protein histidine kinase activity
BD65_RS04005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BD65_RS04010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD65_RS04020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BD65_RS04030	COG4574	serine-type endopeptidase inhibitor activity
BD65_RS04040	COG2246	polysaccharide biosynthetic process
BD65_RS04055	COG0814	amino acid
BD65_RS04080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BD65_RS04085	COG0596	Alpha beta hydrolase
BD65_RS04090	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BD65_RS04095	COG1169	isochorismate synthase
BD65_RS04100	COG4575	ribosome binding
BD65_RS04115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_RS04120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BD65_RS04130	COG0839	Belongs to the complex I subunit 6 family
BD65_RS04135	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_RS04140	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BD65_RS04145	COG1034	ATP synthesis coupled electron transport
BD65_RS04165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_RS04170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BD65_RS04175	COG0583	DNA-binding transcription factor activity
BD65_RS04185	COG0436	Aminotransferase
BD65_RS04190	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BD65_RS04195	COG0490	domain, Protein
BD65_RS04195	COG0471	metal ion transport
BD65_RS04205	COG3013	Belongs to the UPF0304 family
BD65_RS04210	COG3092	negative regulation of chromosome organization
BD65_RS04220	COG0857	belongs to the CobB CobQ family
BD65_RS04220	COG0280	phosphate acetyltransferase
BD65_RS04225	COG1609	Transcriptional regulator
BD65_RS04240	COG3037	sugar-specific permease SgaT UlaA
BD65_RS04245	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BD65_RS04250	COG0622	Phosphoesterase
BD65_RS04260	COG0625	glutathione transferase activity
BD65_RS04265	COG1090	epimerase
BD65_RS04275	COG4160	amino acid transport
BD65_RS04280	COG4215	(ABC) transporter
BD65_RS04290	COG0163	prenyltransferase activity
BD65_RS04295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BD65_RS04300	COG1286	toxin biosynthetic process
BD65_RS04305	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BD65_RS04310	COG0285	dihydrofolate synthase activity
BD65_RS04320	COG0586	Pfam SNARE associated Golgi protein
BD65_RS04330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BD65_RS04355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BD65_RS04360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD65_RS04390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BD65_RS04405	COG3101	peptidyl-lysine hydroxylation
BD65_RS04410	COG0730	response to heat
BD65_RS04415	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BD65_RS04425	COG2890	protein-(glutamine-N5) methyltransferase activity
BD65_RS04430	COG2840	Smr protein MutS2
BD65_RS04435	COG2062	phosphohistidine phosphatase, SixA
BD65_RS04440	COG1024	Enoyl-CoA hydratase
BD65_RS04440	COG1250	3-hydroxyacyl-CoA dehydrogenase
BD65_RS04445	COG0183	Belongs to the thiolase family
BD65_RS04450	COG3691	Protein conserved in bacteria
BD65_RS04465	COG3088	subunit of a heme lyase
BD65_RS04465	COG4235	cytochrome complex assembly
BD65_RS04470	COG3088	subunit of a heme lyase
BD65_RS04470	COG4235	cytochrome complex assembly
BD65_RS04475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BD65_RS04480	COG1138	Cytochrome C-type biogenesis protein
BD65_RS04485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BD65_RS04490	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD65_RS04495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD65_RS04500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BD65_RS04520	COG2824	Alkylphosphonate utilization operon protein PhnA
BD65_RS04525	COG2951	lytic endotransglycosylase activity
BD65_RS04535	COG3038	cytochrome b561
BD65_RS04540	COG0436	Aminotransferase
BD65_RS04550	COG3275	phosphorelay sensor kinase activity
BD65_RS04555	COG3279	Response regulator of the LytR AlgR family
BD65_RS04560	COG2223	nitrite transmembrane transporter activity
BD65_RS04565	COG0837	glucose binding
BD65_RS04585	COG1914	H( )-stimulated, divalent metal cation uptake system
BD65_RS04590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BD65_RS04650	COG3530	Putative quorum-sensing-regulated virulence factor
BD65_RS04655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BD65_RS04665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
BD65_RS04675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_RS04690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BD65_RS04700	COG4208	sulfate ABC transporter
BD65_RS04705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BD65_RS04710	COG4150	thiosulfate binding
BD65_RS04720	COG1737	Transcriptional regulator
BD65_RS04725	COG2731	YhcH YjgK YiaL family protein
BD65_RS04740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BD65_RS04745	COG2837	iron assimilation
BD65_RS04755	COG3111	PFAM Bacterial OB fold (BOF) protein
BD65_RS04770	COG1671	Belongs to the UPF0178 family
BD65_RS04775	COG0280	phosphate acetyltransferase
BD65_RS04775	COG0281	malic enzyme
BD65_RS04780	COG0494	nUDIX hydrolase
BD65_RS04785	COG3005	denitrification pathway
BD65_RS04790	COG3043	anaerobic respiration
BD65_RS04795	COG0243	molybdopterin cofactor binding
BD65_RS04800	COG3062	negative regulation of establishment of protein localization
BD65_RS04815	COG2197	response regulator
BD65_RS04825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_RS04835	COG1605	Chorismate mutase
BD65_RS04840	COG1393	Belongs to the ArsC family
BD65_RS04845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BD65_RS04850	COG1876	peptidase activity
BD65_RS04860	COG0400	carboxylic ester hydrolase activity
BD65_RS04880	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BD65_RS04885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BD65_RS04890	COG2716	regulation of RNA biosynthetic process
BD65_RS04895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BD65_RS04900	COG0628	permease
BD65_RS04905	COG4783	chaperone-mediated protein folding
BD65_RS04910	COG1393	Belongs to the ArsC family
BD65_RS04915	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BD65_RS04920	COG2233	PERMEase
BD65_RS04925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BD65_RS04930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BD65_RS04935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BD65_RS04940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_RS04950	COG0581	inorganic phosphate transmembrane transporter activity
BD65_RS04955	COG0573	inorganic phosphate transmembrane transporter activity
BD65_RS04960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BD65_RS04975	COG2239	Acts as a magnesium transporter
BD65_RS04980	COG0443	Heat shock 70 kDa protein
BD65_RS04990	COG3121	Chaperone
BD65_RS05005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_RS05015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_RS05020	COG0477	Major facilitator Superfamily
BD65_RS05025	COG2205	protein histidine kinase activity
BD65_RS05030	COG0745	RESPONSE REGULATOR receiver
BD65_RS05035	COG3422	double-strand break repair
BD65_RS05040	COG0826	peptidase U32
BD65_RS05045	COG1597	lipid kinase activity
BD65_RS05060	COG0351	phosphomethylpyrimidine kinase
BD65_RS05070	COG0519	Catalyzes the synthesis of GMP from XMP
BD65_RS05070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BD65_RS05075	COG0517	IMP dehydrogenase activity
BD65_RS05075	COG0516	GMP reductase activity
BD65_RS05080	COG1570	exodeoxyribonuclease VII activity
BD65_RS05090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD65_RS05095	COG2976	Protein conserved in bacteria
BD65_RS05100	COG0124	histidyl-tRNA synthetase
BD65_RS05135	COG4953	penicillin-binding protein 1C
BD65_RS05140	COG2373	Large extracellular alpha-helical protein
BD65_RS05155	COG2975	iron-sulfur cluster assembly
BD65_RS05160	COG0633	Ferredoxin
BD65_RS05165	COG0443	Heat shock 70 kDa protein
BD65_RS05170	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BD65_RS05180	COG0822	iron-sulfur transferase activity
BD65_RS05190	COG1959	2 iron, 2 sulfur cluster binding
BD65_RS05195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BD65_RS05205	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BD65_RS05210	COG3683	transport system, periplasmic component
BD65_RS05215	COG3711	transcriptional antiterminator
BD65_RS05220	COG2814	Major facilitator Superfamily
BD65_RS05230	COG1017	nitric oxide dioxygenase activity
BD65_RS05230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BD65_RS05235	COG2188	Transcriptional regulator
BD65_RS05245	COG3457	Alanine racemase
BD65_RS05250	COG1735	metal-dependent hydrolase with the TIM-barrel fold
BD65_RS05265	COG0347	Belongs to the P(II) protein family
BD65_RS05270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BD65_RS05270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD65_RS05275	COG2204	response regulator
BD65_RS05280	COG3170	Tfp pilus assembly protein FimV
BD65_RS05285	COG2205	protein histidine kinase activity
BD65_RS05300	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BD65_RS05320	COG1737	Transcriptional regulator
BD65_RS05325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BD65_RS05330	COG0736	holo-[acyl-carrier-protein] synthase activity
BD65_RS05335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BD65_RS05345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BD65_RS05360	COG0481	GTPase activity
BD65_RS05365	COG3086	response to oxidative stress
BD65_RS05375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BD65_RS05385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BD65_RS05395	COG0513	Belongs to the DEAD box helicase family
BD65_RS05410	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
BD65_RS05420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BD65_RS05425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BD65_RS05430	COG0497	DNA recombination
BD65_RS05435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD65_RS05445	COG2867	negative regulation of translational initiation
BD65_RS05450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BD65_RS05455	COG0582	viral genome integration into host DNA
BD65_RS05465	COG1204	response to ionizing radiation
BD65_RS05505	COG0582	viral genome integration into host DNA
BD65_RS05515	COG2963	transposase activity
BD65_RS05525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BD65_RS05535	COG1172	Belongs to the binding-protein-dependent transport system permease family
BD65_RS05540	COG1129	ABC transporter
BD65_RS05565	COG1620	l-lactate permease
BD65_RS05570	COG1304	FMN binding
BD65_RS05575	COG0579	oxidoreductase
BD65_RS05585	COG1278	Cold shock
BD65_RS05615	COG1780	Probably involved in ribonucleotide reductase function
BD65_RS05620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD65_RS05625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BD65_RS05630	COG4175	Glycine betaine
BD65_RS05635	COG4176	ABC-type proline glycine betaine transport system permease component
BD65_RS05640	COG2113	Glycine betaine
BD65_RS05655	COG1846	Transcriptional regulator
BD65_RS05665	COG1566	PFAM secretion protein HlyD family protein
BD65_RS05670	COG2814	Major facilitator Superfamily
BD65_RS05675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD65_RS05680	COG3118	belongs to the thioredoxin family
BD65_RS05685	COG3148	PFAM DTW domain containing protein
BD65_RS05690	COG1042	CoA-binding domain protein
BD65_RS05690	COG0045	succinate-CoA ligase (ADP-forming) activity
BD65_RS05690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BD65_RS05695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BD65_RS05700	COG5544	Lipoprotein
BD65_RS05725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BD65_RS05735	COG2011	ABC-type metal ion transport system permease component
BD65_RS05740	COG1464	Belongs to the NlpA lipoprotein family
BD65_RS05750	COG1720	tRNA m6t6A37 methyltransferase activity
BD65_RS05755	COG0442	prolyl-tRNA aminoacylation
BD65_RS05760	COG3015	lipoprotein NlpE involved in copper resistance
BD65_RS05770	COG4681	YaeQ
BD65_RS05780	COG4568	rho-dependent transcription termination
BD65_RS05795	COG0346	lactoylglutathione lyase activity
BD65_RS05815	COG0825	malonyl-CoA metabolic process
BD65_RS05820	COG0587	DNA-directed DNA polymerase activity
BD65_RS05825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BD65_RS05845	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD65_RS05850	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BD65_RS05860	COG0750	zinc metalloprotease
BD65_RS05865	COG0575	Belongs to the CDS family
BD65_RS05885	COG0528	UMP kinase activity
BD65_RS05890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BD65_RS05905	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BD65_RS05910	COG2171	N-acyltransferase activity
BD65_RS05925	COG0564	pseudouridine synthase activity
BD65_RS05930	COG3098	single-species biofilm formation
BD65_RS05945	COG1611	Belongs to the LOG family
BD65_RS05955	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
BD65_RS05960	COG2363	Small membrane protein
BD65_RS05965	COG0583	DNA-binding transcription factor activity
BD65_RS05970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BD65_RS05975	COG2166	iron-sulfur cluster assembly
BD65_RS05980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BD65_RS05985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BD65_RS06005	COG0860	N-Acetylmuramoyl-L-alanine amidase
BD65_RS06010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BD65_RS06010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BD65_RS06015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BD65_RS06020	COG1074	ATP-dependent DNA helicase activity
BD65_RS06025	COG1025	Belongs to the peptidase M16 family
BD65_RS06030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BD65_RS06060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BD65_RS06065	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BD65_RS06075	COG3066	DNA modification
BD65_RS06080	COG0861	Integral membrane protein TerC family
BD65_RS06085	COG0667	Aldo Keto reductase
BD65_RS06090	COG0477	Major facilitator Superfamily
BD65_RS06095	COG0204	Acyl-transferase
BD65_RS06095	COG0318	PFAM AMP-dependent synthetase and ligase
BD65_RS06100	COG1609	Transcriptional regulator
BD65_RS06110	COG0583	DNA-binding transcription factor activity
BD65_RS06115	COG0583	DNA-binding transcription factor activity
BD65_RS06170	COG2165	general secretion pathway protein
BD65_RS06180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD65_RS06210	COG1127	ABC transporter
BD65_RS06215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD65_RS06225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BD65_RS06230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BD65_RS06235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BD65_RS06240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BD65_RS06245	COG4974	Belongs to the 'phage' integrase family
BD65_RS06250	COG0716	FMN binding
BD65_RS06260	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BD65_RS06270	COG1272	protein, Hemolysin III
BD65_RS06285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BD65_RS06290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD65_RS06295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD65_RS06300	COG0006	proline dipeptidase activity
BD65_RS06310	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BD65_RS06315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BD65_RS06320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BD65_RS06325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BD65_RS06340	COG1279	arginine transmembrane transporter activity
BD65_RS06350	COG0191	fructose-bisphosphate aldolase activity
BD65_RS06355	COG0126	phosphoglycerate kinase activity
BD65_RS06360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BD65_RS06365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BD65_RS06375	COG1166	arginine decarboxylase activity
BD65_RS06385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BD65_RS06400	COG0640	Transcriptional regulator
BD65_RS06405	COG3091	SprT-like family
BD65_RS06410	COG2356	endonuclease I
BD65_RS06415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BD65_RS06420	COG0189	ligase activity
BD65_RS06425	COG1678	Uncharacterized ACR, COG1678
BD65_RS06430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BD65_RS06435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD65_RS06445	COG2805	Type II/IV secretion system protein
BD65_RS06450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BD65_RS06455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BD65_RS06460	COG0762	integral membrane protein
BD65_RS06465	COG1872	DUF167
BD65_RS06470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BD65_RS06475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BD65_RS06490	COG3171	Protein conserved in bacteria
BD65_RS06500	COG1194	a g-specific adenine glycosylase
BD65_RS06505	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BD65_RS06510	COG0741	lytic transglycosylase activity
BD65_RS06520	COG2336	PFAM SpoVT AbrB
BD65_RS06525	COG2337	Toxic component of a toxin-antitoxin (TA) module
BD65_RS06545	COG1105	Belongs to the carbohydrate kinase PfkB family
BD65_RS06550	COG1882	Formate acetyltransferase
BD65_RS06555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BD65_RS06560	COG0814	amino acid
BD65_RS06575	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_RS06580	COG3433	isochorismatase activity
BD65_RS06580	COG1535	isochorismatase
BD65_RS06585	COG1021	2,3-dihydroxybenzoate-AMP ligase
BD65_RS06590	COG1169	isochorismate synthase
BD65_RS06595	COG4592	Periplasmic binding protein
BD65_RS06605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_RS06610	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_RS06615	COG1120	ATPase activity
BD65_RS06625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BD65_RS06630	COG3251	PFAM MbtH domain protein
BD65_RS06640	COG4774	siderophore transport
BD65_RS06645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BD65_RS06670	COG4964	Belongs to the GSP D family
BD65_RS06720	COG0848	biopolymer transport protein
BD65_RS06725	COG0811	peptide transport
BD65_RS06730	COG0626	cystathionine gamma-synthase activity
BD65_RS06735	COG0586	Pfam SNARE associated Golgi protein
BD65_RS06740	COG2207	Transcriptional regulator
BD65_RS06745	COG1979	alcohol dehydrogenase
BD65_RS06750	COG0656	L-ascorbic acid biosynthetic process
BD65_RS06760	COG2132	Multicopper oxidase
BD65_RS06775	COG2249	NAD(P)H dehydrogenase (quinone) activity
BD65_RS06785	COG0187	DNA topoisomerase II activity
BD65_RS06790	COG3150	esterase
BD65_RS06795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BD65_RS06800	COG3151	Protein conserved in bacteria
BD65_RS06805	COG0494	nUDIX hydrolase
BD65_RS06810	COG1538	Outer membrane efflux protein
BD65_RS06820	COG0754	glutathionylspermidine amidase activity
BD65_RS06825	COG3384	dioxygenase
BD65_RS06830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BD65_RS06840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BD65_RS06840	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BD65_RS06850	COG3025	triphosphatase activity
BD65_RS06855	COG4991	sh3 domain protein
BD65_RS06860	COG0617	tRNA 3'-terminal CCA addition
BD65_RS06865	COG1968	undecaprenyl-diphosphatase activity
BD65_RS06870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BD65_RS06875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BD65_RS06880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BD65_RS06885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BD65_RS06890	COG0358	DNA primase activity
BD65_RS06930	COG2003	Belongs to the UPF0758 family
BD65_RS06950	COG2378	regulation of single-species biofilm formation
BD65_RS06955	COG3596	GTP binding
BD65_RS06985	COG1479	Protein of unknown function DUF262
BD65_RS06995	COG1204	response to ionizing radiation
BD65_RS07020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BD65_RS07060	COG2963	transposase activity
BD65_RS07065	COG1388	LysM domain
BD65_RS07075	COG2963	transposase activity
BD65_RS07080	COG2801	Transposase and inactivated derivatives
BD65_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_RS07110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BD65_RS07150	COG3210	domain, Protein
BD65_RS07155	COG2831	hemolysin activation secretion protein
BD65_RS07160	COG0446	pyridine nucleotide-disulphide oxidoreductase
BD65_RS07160	COG1902	pentaerythritol trinitrate reductase activity
BD65_RS07175	COG1451	nucleotide metabolic process
BD65_RS07180	COG0673	inositol 2-dehydrogenase activity
BD65_RS07185	COG0861	Integral membrane protein TerC family
BD65_RS07190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BD65_RS07200	COG2721	sulfolactate sulfo-lyase activity
BD65_RS07215	COG2271	Major facilitator Superfamily
BD65_RS07230	COG0586	Pfam SNARE associated Golgi protein
BD65_RS07245	COG4575	ribosome binding
BD65_RS07250	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BD65_RS07260	COG2259	Doxx family
BD65_RS07265	COG0583	DNA-binding transcription factor activity
BD65_RS07270	COG1741	Belongs to the pirin family
BD65_RS07280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BD65_RS07295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BD65_RS07300	COG2823	Periplasmic or secreted lipoprotein
BD65_RS07305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD65_RS07310	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BD65_RS07315	COG5002	protein histidine kinase activity
BD65_RS07315	COG2198	Histidine kinase
BD65_RS07315	COG0784	Response regulator, receiver
BD65_RS07325	COG1242	4 iron, 4 sulfur cluster binding
BD65_RS07330	COG0069	glutamate synthase activity
BD65_RS07330	COG0067	glutamate synthase
BD65_RS07330	COG0070	glutamate synthase
BD65_RS07335	COG0493	'glutamate synthase
BD65_RS07355	COG2969	positive regulation of protein catabolic process
BD65_RS07360	COG0625	glutathione transferase activity
BD65_RS07365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BD65_RS07370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BD65_RS07375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BD65_RS07380	COG3105	Protein conserved in bacteria
BD65_RS07385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD65_RS07395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BD65_RS07400	COG5007	Belongs to the BolA IbaG family
BD65_RS07405	COG3113	response to antibiotic
BD65_RS07410	COG2854	intermembrane phospholipid transfer
BD65_RS07415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BD65_RS07420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BD65_RS07425	COG1127	ABC transporter
BD65_RS07430	COG0530	calcium, potassium:sodium antiporter activity
BD65_RS07435	COG0517	IMP dehydrogenase activity
BD65_RS07435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BD65_RS07440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BD65_RS07445	COG3117	lipopolysaccharide transmembrane transporter activity
BD65_RS07450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BD65_RS07455	COG1137	ATPase activity
BD65_RS07460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BD65_RS07480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_RS07485	COG0540	Belongs to the ATCase OTCase family
BD65_RS07490	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BD65_RS07500	COG0366	Alpha amylase catalytic
BD65_RS07505	COG1263	PTS System
BD65_RS07505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_RS07515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BD65_RS07530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD65_RS07535	COG3783	Cytochrome b(562)
BD65_RS07540	COG0312	modulator of DNA gyrase
BD65_RS07545	COG3028	Belongs to the UPF0307 family
BD65_RS07550	COG2732	(Barnase) inhibitor
BD65_RS07555	COG4290	ribonuclease
BD65_RS07565	COG1289	transmembrane transporter activity
BD65_RS07570	COG1566	PFAM secretion protein HlyD family protein
BD65_RS07580	COG0583	DNA-binding transcription factor activity
BD65_RS07585	COG0312	modulator of DNA gyrase
BD65_RS07590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BD65_RS07595	COG3164	Protein of unknown function
BD65_RS07605	COG0424	maF-like protein
BD65_RS07610	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BD65_RS07615	COG1792	Involved in formation and maintenance of cell shape
BD65_RS07620	COG1077	Cell shape determining protein MreB Mrl
BD65_RS07625	COG2199	diguanylate cyclase activity
BD65_RS07625	COG2200	EAL domain
BD65_RS07630	COG0604	alcohol dehydrogenase
BD65_RS07635	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BD65_RS07640	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BD65_RS07650	COG0511	ligase activity, forming carbon-carbon bonds
BD65_RS07655	COG0439	Biotin carboxylase
BD65_RS07660	COG3924	membrane
BD65_RS07665	COG4145	pantothenate transmembrane transporter activity
BD65_RS07670	COG2264	protein methyltransferase activity
BD65_RS07675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD65_RS07680	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BD65_RS07690	COG1560	Kdo2-lipid A biosynthetic process
BD65_RS07700	COG1346	cytolysis
BD65_RS07705	COG1380	Effector of murein hydrolase LrgA
BD65_RS07710	COG0583	DNA-binding transcription factor activity
BD65_RS07715	COG0025	NhaP-type Na H and K H
BD65_RS07720	COG2252	PERMEase
BD65_RS07735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BD65_RS07740	COG2315	Protein conserved in bacteria
BD65_RS07745	COG1448	Aminotransferase
BD65_RS07760	COG0604	alcohol dehydrogenase
BD65_RS07770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD65_RS07775	COG0735	belongs to the Fur family
BD65_RS07780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BD65_RS07785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BD65_RS07790	COG2937	Belongs to the GPAT DAPAT family
BD65_RS07810	COG4580	involved in the transport of maltose and maltodextrins
BD65_RS07825	COG2182	Extracellular solute-binding protein
BD65_RS07830	COG1175	transmembrane transport
BD65_RS07835	COG3833	ABC-type maltose transport systems, permease component
BD65_RS07840	COG3223	Belongs to the PsiE family
BD65_RS07850	COG0527	aspartate kinase activity
BD65_RS07875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BD65_RS07910	COG3409	Peptidoglycan-binding domain 1 protein
BD65_RS07910	COG3501	Rhs element vgr protein
BD65_RS07950	COG0583	DNA-binding transcription factor activity
BD65_RS07975	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BD65_RS07985	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BD65_RS08030	COG0138	bifunctional purine biosynthesis protein purh
BD65_RS08035	COG0151	Belongs to the GarS family
BD65_RS08055	COG1515	deoxyribonuclease V activity
BD65_RS08060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BD65_RS08065	COG2816	NAD+ diphosphatase activity
BD65_RS08070	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
BD65_RS08085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BD65_RS08090	COG2104	thiamine diphosphate biosynthetic process
BD65_RS08095	COG2022	thiamine diphosphate biosynthetic process
BD65_RS08105	COG0823	Involved in the tonB-independent uptake of proteins
BD65_RS08115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BD65_RS08120	COG0085	RNA polymerase activity
BD65_RS08125	COG0222	ribosome binding
BD65_RS08130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BD65_RS08140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BD65_RS08145	COG0250	Participates in transcription elongation, termination and antitermination
BD65_RS08190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BD65_RS08220	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BD65_RS08225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BD65_RS08230	COG1739	Uncharacterized protein family UPF0029
BD65_RS08240	COG1024	Enoyl-CoA hydratase
BD65_RS08240	COG1250	3-hydroxyacyl-CoA dehydrogenase
BD65_RS08250	COG0543	2 iron, 2 sulfur cluster binding
BD65_RS08265	COG0250	Participates in transcription elongation, termination and antitermination
BD65_RS08280	COG0805	protein transport
BD65_RS08290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BD65_RS08295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BD65_RS08300	COG3165	ubiquinone biosynthetic process from chorismate
BD65_RS08305	COG2226	methyltransferase
BD65_RS08310	COG1322	Protein conserved in bacteria
BD65_RS08315	COG0586	Pfam SNARE associated Golgi protein
BD65_RS08320	COG1966	Carbon starvation protein
BD65_RS08335	COG0412	Dienelactone hydrolase
BD65_RS08340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BD65_RS08345	COG0583	DNA-binding transcription factor activity
BD65_RS08360	COG0584	glycerophosphoryl diester phosphodiesterase
BD65_RS08370	COG0395	ABC-type sugar transport system, permease component
BD65_RS08375	COG1175	transmembrane transport
BD65_RS08380	COG1653	transport
BD65_RS08415	COG0410	ABC transporter
BD65_RS08425	COG4177	L-phenylalanine transmembrane transporter activity
BD65_RS08445	COG1929	Belongs to the glycerate kinase type-1 family
BD65_RS08450	COG2610	gluconate transmembrane transporter activity
BD65_RS08455	COG3835	regulator
BD65_RS08465	COG2177	Part of the ABC transporter FtsEX involved in
BD65_RS08470	COG2884	Cell division ATP-binding protein ftsE
BD65_RS08475	COG0552	protein localization to endoplasmic reticulum
BD65_RS08475	COG0552	protein localization to endoplasmic reticulum
BD65_RS08480	COG0742	ribosomal rna small subunit methyltransferase
BD65_RS08485	COG3776	membrane
BD65_RS08500	COG3714	YhhN family
BD65_RS08515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BD65_RS08535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BD65_RS08545	COG2271	Major facilitator Superfamily
BD65_RS08550	COG0584	glycerophosphoryl diester phosphodiesterase
BD65_RS08555	COG0561	phosphatase activity
BD65_RS08560	COG2267	carboxylic ester hydrolase activity
BD65_RS08565	COG1280	lysine exporter protein (LysE YggA)
BD65_RS08570	COG0514	ATP-dependent DNA helicase (RecQ)
BD65_RS08575	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BD65_RS08580	COG2050	protein possibly involved in aromatic compounds catabolism
BD65_RS08600	COG5564	TIM-barrel signal transduction protein
BD65_RS08605	COG5441	Belongs to the UPF0261 family
BD65_RS08615	COG0210	DNA helicase
BD65_RS08620	COG1011	Hydrolase
BD65_RS08625	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BD65_RS08630	COG3159	Protein conserved in bacteria
BD65_RS08635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BD65_RS08640	COG5567	small periplasmic lipoprotein
BD65_RS08650	COG3072	Adenylate cyclase
BD65_RS08655	COG0181	hydroxymethylbilane synthase activity
BD65_RS08660	COG1587	Uroporphyrinogen-III synthase
BD65_RS08665	COG2959	enzyme of heme biosynthesis
BD65_RS08670	COG3071	HemY protein
BD65_RS08715	COG2244	polysaccharide biosynthetic process
BD65_RS08720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BD65_RS08725	COG0456	acetyltransferase
BD65_RS08730	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BD65_RS08735	COG1088	dTDP-glucose 4,6-dehydratase activity
BD65_RS08740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BD65_RS08745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BD65_RS08750	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BD65_RS08755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BD65_RS08760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BD65_RS08765	COG3118	belongs to the thioredoxin family
BD65_RS08775	COG0248	Ppx GppA phosphatase
BD65_RS08785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD65_RS08795	COG0583	DNA-binding transcription factor activity
BD65_RS08800	COG3397	chitin binding
BD65_RS08810	COG0129	dihydroxy-acid dehydratase activity
BD65_RS08820	COG3978	acetolactate synthase activity
BD65_RS08830	COG0606	chelatase, subunit chli
BD65_RS08835	COG3085	chromosome segregation
BD65_RS08840	COG0583	DNA-binding transcription factor activity
BD65_RS08920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_RS08930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BD65_RS08930	COG0678	peroxiredoxin activity
BD65_RS08970	COG1629	transport
BD65_RS08975	COG0165	Argininosuccinate lyase
BD65_RS08980	COG0137	argininosuccinate synthase activity
BD65_RS08985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BD65_RS09030	COG0460	homoserine dehydrogenase
BD65_RS09030	COG0527	aspartate kinase activity
BD65_RS09035	COG0626	cystathionine gamma-synthase activity
BD65_RS09040	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BD65_RS09050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BD65_RS09055	COG1609	Transcriptional regulator
BD65_RS09060	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BD65_RS09065	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BD65_RS09075	COG1575	Belongs to the MenA family. Type 1 subfamily
BD65_RS09080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BD65_RS09085	COG3074	FtsZ-dependent cytokinesis
BD65_RS09090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BD65_RS09095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BD65_RS09100	COG1494	fructose-1,6-bisphosphatase
BD65_RS09105	COG2814	Major facilitator Superfamily
BD65_RS09115	COG3152	Membrane
BD65_RS09130	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BD65_RS09140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BD65_RS09180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BD65_RS09270	COG4695	Portal protein
BD65_RS09350	COG3678	ATP-independent chaperone mediated protein folding
BD65_RS09355	COG0745	RESPONSE REGULATOR receiver
BD65_RS09360	COG2205	protein histidine kinase activity
BD65_RS09365	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BD65_RS09370	COG1045	serine acetyltransferase
BD65_RS09375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BD65_RS09380	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BD65_RS09385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BD65_RS09390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BD65_RS09395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BD65_RS09400	COG4942	peptidase
BD65_RS09405	COG2861	carbohydrate metabolic process
BD65_RS09420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD65_RS09425	COG0859	PFAM glycosyl transferase family 9
BD65_RS09430	COG0859	PFAM glycosyl transferase family 9
BD65_RS09435	COG1519	Transferase
BD65_RS09455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BD65_RS09460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BD65_RS09465	COG2003	Belongs to the UPF0758 family
BD65_RS09470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BD65_RS09475	COG0756	dUTP diphosphatase activity
BD65_RS09480	COG1309	transcriptional regulator
BD65_RS09485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BD65_RS09490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BD65_RS09495	COG1561	YicC-like family, N-terminal region
BD65_RS09510	COG5001	Diguanylate cyclase
BD65_RS09515	COG1024	Enoyl-CoA hydratase
BD65_RS09525	COG2860	membrane
BD65_RS09530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BD65_RS09540	COG1758	RNA polymerase activity
BD65_RS09545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BD65_RS09550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD65_RS09555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BD65_RS09560	COG0786	glutamate:sodium symporter activity
BD65_RS09565	COG2233	PERMEase
BD65_RS09570	COG2982	Protein involved in outer membrane biogenesis
BD65_RS09575	COG0456	acetyltransferase
BD65_RS09590	COG1011	Hydrolase
BD65_RS09605	COG3852	Histidine kinase
BD65_RS09615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BD65_RS09625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BD65_RS09630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BD65_RS09630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BD65_RS09635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BD65_RS09640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BD65_RS09645	COG3084	Protein conserved in bacteria
BD65_RS09655	COG1763	Mo-molybdopterin cofactor biosynthetic process
BD65_RS09680	COG2186	Transcriptional regulator
BD65_RS09685	COG1609	Transcriptional regulator
BD65_RS09690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BD65_RS09700	COG1172	Belongs to the binding-protein-dependent transport system permease family
BD65_RS09705	COG1129	ABC transporter
BD65_RS09710	COG1869	D-ribose catabolic process
BD65_RS09715	COG3158	transport of potassium into the cell
BD65_RS09720	COG0714	Associated with various cellular activities
BD65_RS09725	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BD65_RS09735	COG2502	aspartate--ammonia ligase
BD65_RS09740	COG1522	sequence-specific DNA binding
BD65_RS09745	COG0716	FMN binding
BD65_RS09750	COG0445	tRNA wobble uridine modification
BD65_RS09755	COG0357	Ribosomal RNA small subunit methyltransferase G
BD65_RS09760	COG3312	ion transport
BD65_RS09765	COG0356	it plays a direct role in the translocation of protons across the membrane
BD65_RS09775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BD65_RS09785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BD65_RS09790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BD65_RS09795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BD65_RS09800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BD65_RS09820	COG0675	Transposase, IS605 OrfB family
BD65_RS09825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BD65_RS09830	COG0573	inorganic phosphate transmembrane transporter activity
BD65_RS09835	COG0581	inorganic phosphate transmembrane transporter activity
BD65_RS09845	COG0704	Plays a role in the regulation of phosphate uptake
BD65_RS09850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_RS09855	COG0765	amino acid transport
BD65_RS09860	COG0765	amino acid transport
BD65_RS09865	COG2252	PERMEase
BD65_RS09870	COG0840	transmembrane signaling receptor activity
BD65_RS09880	COG3121	Chaperone
BD65_RS09905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BD65_RS09910	COG0706	membrane insertase activity
BD65_RS09920	COG0594	ribonuclease P activity
BD65_RS09925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BD65_RS09935	COG0592	DNA-directed DNA polymerase activity
BD65_RS09945	COG0187	DNA topoisomerase II activity
BD65_RS09950	COG0561	phosphatase activity
BD65_RS09955	COG0823	Involved in the tonB-independent uptake of proteins
BD65_RS09960	COG5645	(Lipo)protein
BD65_RS09975	COG0569	domain protein
BD65_RS09975	COG2985	domain, Protein
BD65_RS09980	COG3977	Valine--pyruvate aminotransferase
BD65_RS09985	COG2885	chlorophyll binding
BD65_RS10005	COG2818	Glycosylase
BD65_RS10055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_RS10055	COG2213	PTS system mannitol-specific
BD65_RS10065	COG3722	fumarate hydratase activity
BD65_RS10075	COG2258	MOSC domain
BD65_RS10080	COG0840	transmembrane signaling receptor activity
BD65_RS10085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BD65_RS10095	COG0243	molybdopterin cofactor binding
BD65_RS10095	COG3383	formate dehydrogenase (NAD+) activity
BD65_RS10100	COG0243	molybdopterin cofactor binding
BD65_RS10100	COG3383	formate dehydrogenase (NAD+) activity
BD65_RS10105	COG0437	4 iron, 4 sulfur cluster binding
BD65_RS10110	COG2864	formate dehydrogenase
BD65_RS10120	COG1921	L-seryl-tRNASec selenium transferase activity
BD65_RS10125	COG3276	selenocysteine insertion sequence binding
BD65_RS10130	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BD65_RS10140	COG3274	enterobacterial common antigen metabolic process
BD65_RS10145	COG3344	reverse transcriptase
BD65_RS10160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BD65_RS10165	COG2986	histidine ammonia-lyase
BD65_RS10185	COG2194	sulfuric ester hydrolase activity
BD65_RS10190	COG2197	response regulator
BD65_RS10195	COG3851	Histidine kinase
BD65_RS10200	COG2271	Major facilitator Superfamily
BD65_RS10210	COG0747	negative chemotaxis
BD65_RS10215	COG0601	transmembrane transport
BD65_RS10220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BD65_RS10225	COG0444	Belongs to the ABC transporter superfamily
BD65_RS10230	COG4608	Belongs to the ABC transporter superfamily
BD65_RS10235	COG2194	sulfuric ester hydrolase activity
BD65_RS10260	COG1215	transferase activity, transferring glycosyl groups
BD65_RS10265	COG1215	transferase activity, transferring glycosyl groups
BD65_RS10270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BD65_RS10275	COG3118	belongs to the thioredoxin family
BD65_RS10275	COG0457	Tetratricopeptide repeat
BD65_RS10280	COG2199	diguanylate cyclase activity
BD65_RS10280	COG2200	EAL domain
BD65_RS10285	COG1301	dicarboxylic acid transport
BD65_RS10290	COG0612	Peptidase, M16
BD65_RS10295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BD65_RS10300	COG1942	4-Oxalocrotonate Tautomerase
BD65_RS10305	COG2200	EAL domain
BD65_RS10310	COG2134	cdp-diacylglycerol pyrophosphatase
BD65_RS10315	COG1295	ribonuclease BN
BD65_RS10325	COG1301	dicarboxylic acid transport
BD65_RS10330	COG0626	cystathionine gamma-synthase activity
BD65_RS10335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_RS10340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BD65_RS10345	COG0339	signal peptide processing
BD65_RS10350	COG0742	ribosomal rna small subunit methyltransferase
BD65_RS10360	COG0589	response to stress
BD65_RS10370	COG0306	phosphate transporter
BD65_RS10375	COG2081	HI0933 family
BD65_RS10385	COG1247	-acetyltransferase
BD65_RS10390	COG1741	Belongs to the pirin family
BD65_RS10395	COG1609	Transcriptional regulator
BD65_RS10400	COG2610	gluconate transmembrane transporter activity
BD65_RS10405	COG3265	gluconokinase activity
BD65_RS10410	COG2095	MarC family integral membrane protein
BD65_RS10415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BD65_RS10420	COG3275	phosphorelay sensor kinase activity
BD65_RS10425	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BD65_RS10430	COG1523	belongs to the glycosyl hydrolase 13 family
BD65_RS10435	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BD65_RS10440	COG0297	glycogen (starch) synthase activity
BD65_RS10445	COG0058	SHG alpha-glucan phosphorylase activity
BD65_RS10450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BD65_RS10455	COG1349	DNA-binding transcription factor activity
BD65_RS10460	COG0705	Rhomboid family
BD65_RS10470	COG2909	trisaccharide binding
BD65_RS10475	COG0058	SHG alpha-glucan phosphorylase activity
BD65_RS10480	COG1640	4-alpha-glucanotransferase
BD65_RS10490	COG1040	competence protein
BD65_RS10495	COG0596	Alpha beta hydrolase
BD65_RS10515	COG1918	ferrous iron import across plasma membrane
BD65_RS10520	COG2183	response to ionizing radiation
BD65_RS10545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BD65_RS10560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BD65_RS10570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BD65_RS10575	COG1011	Hydrolase
BD65_RS10585	COG0494	nUDIX hydrolase
BD65_RS10590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BD65_RS10615	COG4796	Type ii and iii secretion system protein
BD65_RS10620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BD65_RS10640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BD65_RS10650	COG0180	Tryptophanyl-tRNA synthetase
BD65_RS10655	COG1648	precorrin-2 dehydrogenase activity
BD65_RS10655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BD65_RS10670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BD65_RS10675	COG0402	S-adenosylhomocysteine deaminase activity
BD65_RS10680	COG0738	Major facilitator superfamily
BD65_RS10695	COG1609	Transcriptional regulator
BD65_RS10700	COG1486	melibiose metabolic process
BD65_RS10710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BD65_RS10725	COG1289	transmembrane transporter activity
BD65_RS10730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BD65_RS10735	COG1765	OsmC-like protein
BD65_RS10755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BD65_RS10760	COG3954	Phosphoribulokinase
BD65_RS10770	COG0429	hydrolase of the alpha beta-hydrolase fold
BD65_RS10780	COG0859	PFAM glycosyl transferase family 9
BD65_RS10785	COG1216	Glycosyl transferase, family 2
BD65_RS10790	COG0488	(ABC) transporter
BD65_RS10795	COG2249	NAD(P)H dehydrogenase (quinone) activity
BD65_RS10805	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BD65_RS10810	COG1047	Peptidyl-prolyl cis-trans
BD65_RS10820	COG0545	Peptidyl-prolyl cis-trans isomerase
BD65_RS10825	COG2964	Protein conserved in bacteria
BD65_RS10835	COG2923	Belongs to the DsrF TusC family
BD65_RS10840	COG2168	tRNA wobble position uridine thiolation
BD65_RS10845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BD65_RS10850	COG0049	tRNA binding
BD65_RS10860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BD65_RS10870	COG0051	transcription antitermination factor activity, RNA binding
BD65_RS10875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BD65_RS10885	COG0089	rRNA binding
BD65_RS10890	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BD65_RS10895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BD65_RS10900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BD65_RS10910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BD65_RS10915	COG0255	Belongs to the universal ribosomal protein uL29 family
BD65_RS10920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BD65_RS10925	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BD65_RS10935	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BD65_RS10960	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BD65_RS10965	COG1841	ribosomal large subunit assembly
BD65_RS10970	COG0200	Binds to the 23S rRNA
BD65_RS10975	COG0201	protein transport
BD65_RS10980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BD65_RS10985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BD65_RS10995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BD65_RS11005	COG0203	ribosomal protein L17
BD65_RS11010	COG0789	Transcriptional regulator
BD65_RS11015	COG3036	rescue of stalled ribosome
BD65_RS11020	COG1970	mechanosensitive ion channel activity
BD65_RS11030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BD65_RS11030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BD65_RS11035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BD65_RS11040	COG0242	peptide deformylase activity
BD65_RS11045	COG0758	DNA mediated transformation
BD65_RS11055	COG0009	L-threonylcarbamoyladenylate synthase
BD65_RS11065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BD65_RS11090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BD65_RS11095	COG3162	membrane
BD65_RS11100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BD65_RS11105	COG1301	dicarboxylic acid transport
BD65_RS11115	COG1309	transcriptional regulator
BD65_RS11120	COG4232	protein-disulfide reductase activity
BD65_RS11130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BD65_RS11160	COG1509	lysine 2,3-aminomutase activity
BD65_RS11170	COG3397	chitin binding
BD65_RS11190	COG3188	usher protein
BD65_RS11210	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BD65_RS11215	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BD65_RS11220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BD65_RS11225	COG1053	succinate dehydrogenase
BD65_RS11230	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
BD65_RS11235	COG3264	Mechanosensitive ion channel
BD65_RS11235	COG1511	domain protein
BD65_RS11240	COG0688	phosphatidylethanolamine metabolic process
BD65_RS11245	COG1162	GTPase activity
BD65_RS11250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BD65_RS11270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BD65_RS11275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BD65_RS11275	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BD65_RS11280	COG0802	atpase or kinase
BD65_RS11295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BD65_RS11300	COG1923	regulation of RNA biosynthetic process
BD65_RS11305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BD65_RS11310	COG0330	HflC and HflK could
BD65_RS11315	COG0330	HflC and HflK could
BD65_RS11320	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BD65_RS11325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BD65_RS11330	COG1959	2 iron, 2 sulfur cluster binding
BD65_RS11335	COG0557	exoribonuclease II activity
BD65_RS11340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BD65_RS11360	COG3121	Chaperone
BD65_RS11365	COG3188	usher protein
BD65_RS11385	COG1073	alpha beta
BD65_RS11395	COG0360	Binds together with S18 to 16S ribosomal RNA
BD65_RS11400	COG2965	DNA replication, synthesis of RNA primer
BD65_RS11405	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BD65_RS11410	COG0359	binds to the 23S rRNA
BD65_RS11415	COG3061	Opacity-associated protein A
BD65_RS11420	COG0545	Peptidyl-prolyl cis-trans isomerase
BD65_RS11430	COG0737	Belongs to the 5'-nucleotidase family
BD65_RS11435	COG1218	3'(2'),5'-bisphosphate nucleotidase
BD65_RS11440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BD65_RS11450	COG1253	flavin adenine dinucleotide binding
BD65_RS11455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BD65_RS11460	COG0729	surface antigen
BD65_RS11465	COG2911	Protein conserved in bacteria
BD65_RS11470	COG2105	PFAM AIG2 family protein
BD65_RS11475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BD65_RS11485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BD65_RS11500	COG3423	Transcriptional regulator
BD65_RS11515	COG0142	geranyltranstransferase activity
BD65_RS11530	COG0697	spore germination
BD65_RS11535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BD65_RS11540	COG0642	Histidine kinase
BD65_RS11545	COG0745	RESPONSE REGULATOR receiver
BD65_RS11550	COG2027	D-alanyl-D-alanine carboxypeptidase
BD65_RS11560	COG1534	Rna-binding protein
BD65_RS11565	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BD65_RS11575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BD65_RS11580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BD65_RS11585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BD65_RS11605	COG0195	Participates in both transcription termination and antitermination
BD65_RS11615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BD65_RS11630	COG1185	polyribonucleotide nucleotidyltransferase activity
BD65_RS11640	COG0513	Belongs to the DEAD box helicase family
BD65_RS11645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BD65_RS11650	COG0814	amino acid
BD65_RS11660	COG0826	peptidase U32
BD65_RS11665	COG0826	peptidase U32
BD65_RS11670	COG3154	lipid carrier protein
BD65_RS11675	COG3153	acetyltransferase
BD65_RS11680	COG2827	Endonuclease containing a URI domain
BD65_RS11685	COG0531	amino acid
BD65_RS11690	COG1982	Orn Lys Arg decarboxylase major
BD65_RS11695	COG3787	Belongs to the UPF0306 family
BD65_RS11700	COG0702	epimerase
BD65_RS11705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BD65_RS11710	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BD65_RS11715	COG3454	Phosphonate metabolism
BD65_RS11720	COG4778	phosphonate C-P lyase system protein PhnL
BD65_RS11725	COG4107	phosphonate C-P lyase system protein PhnK
BD65_RS11730	COG3627	carbon phosphorus lyase activity
BD65_RS11735	COG3626	phosphonate metabolism
BD65_RS11740	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BD65_RS11745	COG3624	Phosphonate C-P lyase system protein PhnG
BD65_RS11770	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BD65_RS11785	COG2927	DNA polymerase III (CHI subunit)
BD65_RS11790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BD65_RS11795	COG0795	lipopolysaccharide-transporting ATPase activity
BD65_RS11800	COG0795	lipopolysaccharide-transporting ATPase activity
BD65_RS11810	COG0582	viral genome integration into host DNA
BD65_RS11880	COG2963	transposase activity
BD65_RS11885	COG2801	Transposase and inactivated derivatives
BD65_RS11905	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BD65_RS11940	COG0582	viral genome integration into host DNA
BD65_RS11960	COG2963	transposase activity
BD65_RS11975	COG5492	domain, Protein
BD65_RS11995	COG3119	arylsulfatase activity
BD65_RS12000	COG1349	DNA-binding transcription factor activity
BD65_RS12010	COG2222	sugar isomerase
BD65_RS12015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_RS12020	COG3715	PTS system
BD65_RS12025	COG3716	PTS system mannose fructose sorbose family IID component
BD65_RS12035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BD65_RS12045	COG1028	Short-chain dehydrogenase reductase Sdr
BD65_RS12055	COG0641	radical SAM
BD65_RS12060	COG3119	arylsulfatase activity
BD65_RS12085	COG0859	PFAM glycosyl transferase family 9
BD65_RS12100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_RS12105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_RS12115	COG2376	Dihydroxyacetone kinase
BD65_RS12120	COG1461	Dihydroxyacetone kinase
BD65_RS12125	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BD65_RS12125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BD65_RS12125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BD65_RS12165	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BD65_RS12180	COG2823	Periplasmic or secreted lipoprotein
BD65_RS12185	COG4667	esterase of the alpha-beta hydrolase superfamily
BD65_RS12190	COG0084	hydrolase, TatD family'
BD65_RS12195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BD65_RS12210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BD65_RS12220	COG3726	membrane protein affecting hemolysin expression
BD65_RS12225	COG0560	Phosphoserine phosphatase
BD65_RS12240	COG0488	(ABC) transporter
BD65_RS12250	COG0741	lytic transglycosylase activity
BD65_RS12255	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
BD65_RS12260	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BD65_RS12265	COG0406	alpha-ribazole phosphatase activity
BD65_RS12270	COG2207	Transcriptional regulator
BD65_RS12270	COG3708	Transcriptional regulator
BD65_RS12275	COG3045	CreA protein
BD65_RS12280	COG0745	RESPONSE REGULATOR receiver
BD65_RS12290	COG0083	homoserine kinase activity
BD65_RS12305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BD65_RS12310	COG0521	Mo-molybdopterin cofactor biosynthetic process
BD65_RS12315	COG0477	Major facilitator Superfamily
BD65_RS12325	COG1584	GPR1 FUN34 yaaH family protein
BD65_RS12330	COG0443	Heat shock 70 kDa protein
BD65_RS12340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BD65_RS12345	COG0583	DNA-binding transcription factor activity
BD65_RS12355	COG0196	riboflavin kinase activity
BD65_RS12365	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BD65_RS12370	COG1047	Peptidyl-prolyl cis-trans
BD65_RS12375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BD65_RS12390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BD65_RS12395	COG1280	lysine exporter protein (LysE YggA)
BD65_RS12400	COG2966	Psort location CytoplasmicMembrane, score
BD65_RS12425	COG2967	ApaG domain
BD65_RS12430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BD65_RS12435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BD65_RS12445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BD65_RS12455	COG0564	pseudouridine synthase activity
BD65_RS12460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BD65_RS12465	COG0417	DNA replication proofreading
BD65_RS12470	COG0586	Pfam SNARE associated Golgi protein
BD65_RS12480	COG1178	ABC-type Fe3 transport system permease component
BD65_RS12485	COG4143	(ABC) transporter
BD65_RS12495	COG2814	Major facilitator Superfamily
BD65_RS12505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BD65_RS12510	COG0473	3-isopropylmalate dehydrogenase activity
BD65_RS12525	COG1022	Amp-dependent synthetase and ligase
BD65_RS12530	COG0028	Belongs to the TPP enzyme family
BD65_RS12555	COG0275	rRNA processing
BD65_RS12560	COG3116	cell division
BD65_RS12565	COG0768	penicillin binding
BD65_RS12570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BD65_RS12575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BD65_RS12590	COG0772	Belongs to the SEDS family
BD65_RS12595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BD65_RS12610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BD65_RS12615	COG0849	cell division
BD65_RS12620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BD65_RS12645	COG0494	nUDIX hydrolase
BD65_RS12665	COG0516	GMP reductase activity
BD65_RS12670	COG1459	type II secretion system
BD65_RS12675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD65_RS12680	COG4969	Belongs to the N-Me-Phe pilin family
BD65_RS12695	COG3725	Membrane protein required for beta-lactamase induction
BD65_RS12705	COG1113	amino acid transport
BD65_RS12710	COG2186	Transcriptional regulator
BD65_RS12715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BD65_RS12720	COG0508	dehydrogenase complex catalyzes the overall conversion of
BD65_RS12725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BD65_RS12735	COG1049	propionate catabolic process, 2-methylcitrate cycle
BD65_RS12740	COG3112	Uncharacterised protein family (UPF0231)
BD65_RS12755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BD65_RS12765	COG2132	Multicopper oxidase
BD65_RS12775	COG0288	reversible hydration of carbon dioxide
BD65_RS12780	COG1131	(ABC) transporter
BD65_RS12785	COG0842	Transport permease protein
BD65_RS12790	COG0726	polysaccharide deacetylase
BD65_RS12795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BD65_RS12800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BD65_RS12805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BD65_RS12810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BD65_RS12815	COG0617	tRNA 3'-terminal CCA addition
BD65_RS12830	COG1489	DNA binding
BD65_RS12835	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BD65_RS12840	COG1643	Atp-dependent helicase
BD65_RS12845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BD65_RS12860	COG0316	Belongs to the HesB IscA family
BD65_RS12865	COG2860	membrane
BD65_RS12875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BD65_RS12880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BD65_RS12885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BD65_RS12895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BD65_RS12900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BD65_RS12905	COG3956	TIGRFAM MazG family protein
BD65_RS12910	COG0504	CTP synthase activity
BD65_RS12920	COG0602	queuosine metabolic process
BD65_RS12925	COG0720	synthase
BD65_RS12930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BD65_RS12940	COG0175	sulfate reduction
BD65_RS12955	COG2234	aminopeptidase activity
BD65_RS12960	COG1648	precorrin-2 dehydrogenase activity
BD65_RS12960	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BD65_RS12965	COG0175	sulfate reduction
BD65_RS12970	COG2895	sulfate adenylyltransferase (ATP) activity
BD65_RS12975	COG0529	Catalyzes the synthesis of activated sulfate
BD65_RS12985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BD65_RS12995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BD65_RS13000	COG0585	pseudouridine synthase activity
BD65_RS13005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BD65_RS13015	COG1388	LysM domain
BD65_RS13015	COG4942	peptidase
BD65_RS13020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BD65_RS13025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BD65_RS13080	COG2205	protein histidine kinase activity
BD65_RS13080	COG0784	Response regulator, receiver
BD65_RS13100	COG0741	lytic transglycosylase activity
BD65_RS13230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BD65_RS13250	COG3397	chitin binding
BD65_RS13260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BD65_RS13295	COG2165	general secretion pathway protein
BD65_RS13305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BD65_RS13315	COG3031	protein transport across the cell outer membrane
BD65_RS13340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BD65_RS13340	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BD65_RS13345	COG0477	Major facilitator Superfamily
BD65_RS13355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BD65_RS13360	COG2137	regulation of response to DNA damage stimulus
BD65_RS13365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BD65_RS13370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BD65_RS13395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BD65_RS13400	COG1238	metal cluster binding
BD65_RS13405	COG2918	glutathione biosynthetic process
BD65_RS13410	COG1854	S-ribosylhomocysteine lyase activity
BD65_RS13415	COG4536	flavin adenine dinucleotide binding
BD65_RS13420	COG4137	Cytochrome C assembly protein
BD65_RS13425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BD65_RS13435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BD65_RS13440	COG0336	Belongs to the RNA methyltransferase TrmD family
BD65_RS13445	COG0335	large ribosomal subunit rRNA binding
BD65_RS13450	COG3137	Salt-induced outer membrane protein
BD65_RS13455	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BD65_RS13460	COG3279	Response regulator of the LytR AlgR family
BD65_RS13465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BD65_RS13470	COG0287	Prephenate dehydrogenase
BD65_RS13470	COG1605	Chorismate mutase
BD65_RS13475	COG1605	Chorismate mutase
BD65_RS13475	COG0077	Prephenate dehydratase
BD65_RS13480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BD65_RS13485	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BD65_RS13490	COG0564	pseudouridine synthase activity
BD65_RS13495	COG1496	oxidoreductase activity
BD65_RS13500	COG0542	response to heat
BD65_RS13545	COG3021	interspecies interaction between organisms
BD65_RS13550	COG0741	lytic transglycosylase activity
BD65_RS13550	COG1388	LysM domain
BD65_RS13560	COG2226	methyltransferase
BD65_RS13570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BD65_RS13580	COG1960	acyl-CoA dehydrogenase activity
BD65_RS13585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BD65_RS13590	COG0121	glutamine amidotransferase
BD65_RS13595	COG3034	peptidoglycan biosynthetic process
BD65_RS13605	COG1805	sodium ion transport
BD65_RS13610	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_RS13615	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_RS13620	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BD65_RS13630	COG1477	protein flavinylation
BD65_RS13635	COG2991	Protein conserved in bacteria
BD65_RS13645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BD65_RS13650	COG2195	Cleaves the N-terminal amino acid of tripeptides
BD65_RS13655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BD65_RS13660	COG1073	alpha beta
BD65_RS13710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BD65_RS13730	COG4126	flavin adenine dinucleotide binding
BD65_RS13740	COG2974	May be involved in recombination
BD65_RS13745	COG1940	carbohydrate kinase activity
BD65_RS13750	COG0419	ATPase involved in DNA repair
BD65_RS13755	COG0420	3'-5' exonuclease activity
BD65_RS13760	COG0745	RESPONSE REGULATOR receiver
BD65_RS13765	COG5002	protein histidine kinase activity
BD65_RS13780	COG1113	amino acid transport
BD65_RS13785	COG0366	Alpha amylase catalytic
BD65_RS13790	COG0300	oxidoreductase activity
BD65_RS13795	COG0450	alkyl hydroperoxide reductase
BD65_RS13800	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
BD65_RS13815	COG1862	Preprotein translocase
BD65_RS13820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BD65_RS13825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BD65_RS13830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BD65_RS13835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BD65_RS13835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BD65_RS13840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BD65_RS13850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BD65_RS13855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BD65_RS13860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BD65_RS13865	COG0142	geranyltranstransferase activity
BD65_RS13900	COG0693	protein deglycase activity
BD65_RS13905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BD65_RS13910	COG1666	GTP binding
BD65_RS13915	COG2814	Major facilitator Superfamily
BD65_RS13925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BD65_RS13930	COG1845	cytochrome c oxidase, subunit III
BD65_RS13935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BD65_RS13940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BD65_RS13950	COG2223	nitrite transmembrane transporter activity
BD65_RS13955	COG3056	Lipoprotein
BD65_RS13960	COG0271	Belongs to the BolA IbaG family
BD65_RS13970	COG0740	serine-type endopeptidase activity
BD65_RS13975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BD65_RS13980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BD65_RS13985	COG0776	regulation of translation
BD65_RS13990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BD65_RS13995	COG1555	photosystem II stabilization
BD65_RS14000	COG0824	Thioesterase
BD65_RS14005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BD65_RS14010	COG4533	DNA binding
BD65_RS14025	COG1522	sequence-specific DNA binding
BD65_RS14030	COG1132	(ABC) transporter
BD65_RS14035	COG1132	(ABC) transporter
BD65_RS14040	COG0347	Belongs to the P(II) protein family
BD65_RS14045	COG0004	ammonium transporteR
BD65_RS14050	COG1946	Acyl-CoA thioesterase
BD65_RS14055	COG3695	enzyme binding
BD65_RS14080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BD65_RS14085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_RS14090	COG1309	transcriptional regulator
BD65_RS14095	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BD65_RS14100	COG3264	Mechanosensitive ion channel
BD65_RS14100	COG1196	nuclear chromosome segregation
BD65_RS14110	COG2832	Protein of unknown function (DUF454)
BD65_RS14115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BD65_RS14145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BD65_RS14155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BD65_RS14165	COG0326	Molecular chaperone. Has ATPase activity
BD65_RS14180	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BD65_RS14185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BD65_RS14190	COG4651	solute:proton antiporter activity
BD65_RS14190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BD65_RS14195	COG0737	Belongs to the 5'-nucleotidase family
BD65_RS14210	COG0500	methyltransferase
BD65_RS14235	COG1086	Polysaccharide biosynthesis protein
BD65_RS14255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BD65_RS14260	COG3735	TraB family
BD65_RS14265	COG2217	Heavy metal translocating P-type atpase
BD65_RS14270	COG0789	Transcriptional regulator
BD65_RS14275	COG1585	Membrane protein implicated in regulation of membrane protease activity
BD65_RS14280	COG0330	HflC and HflK could
BD65_RS14285	COG3118	belongs to the thioredoxin family
BD65_RS14290	COG0300	oxidoreductase activity
BD65_RS14295	COG2755	lipolytic protein G-D-S-L family
BD65_RS14300	COG4181	ATPase activity
BD65_RS14305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BD65_RS14310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BD65_RS14315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BD65_RS14320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BD65_RS14325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BD65_RS14350	COG3188	usher protein
BD65_RS14355	COG3121	Chaperone
BD65_RS14385	COG2501	S4 domain
BD65_RS14390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BD65_RS14400	COG0582	viral genome integration into host DNA
BD65_RS14405	COG2963	transposase activity
BD65_RS14410	COG3344	reverse transcriptase
BD65_RS14430	COG2963	transposase activity
BD65_RS14445	COG0318	PFAM AMP-dependent synthetase and ligase
BD65_RS14470	COG3038	cytochrome b561
BD65_RS14500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BD65_RS14510	COG1215	transferase activity, transferring glycosyl groups
BD65_RS14530	COG3250	beta-galactosidase activity
BD65_RS14535	COG3850	Histidine kinase
BD65_RS14535	COG2205	protein histidine kinase activity
BD65_RS14535	COG3437	response regulator, receiver
BD65_RS14535	COG4999	Histidine kinase
BD65_RS14560	COG2197	response regulator
BD65_RS14565	COG1278	Cold shock
BD65_RS14585	COG3706	GGDEF domain
BD65_RS14595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BD65_RS14605	COG2921	Belongs to the UPF0250 family
BD65_RS14610	COG1686	Belongs to the peptidase S11 family
BD65_RS14615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BD65_RS14620	COG0772	Belongs to the SEDS family
BD65_RS14625	COG0768	penicillin binding
BD65_RS14630	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BD65_RS14635	COG0799	negative regulation of ribosome biogenesis
BD65_RS14640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BD65_RS14645	COG1466	dna polymerase III delta subunit
BD65_RS14650	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BD65_RS14660	COG2888	peptidyl-tyrosine sulfation
BD65_RS14665	COG1126	abc transporter atp-binding protein
BD65_RS14670	COG0765	amino acid transport
BD65_RS14675	COG0765	amino acid transport
BD65_RS14685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BD65_RS14690	COG4535	Mg2 and Co2 transporter CorC
BD65_RS14695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BD65_RS14700	COG1702	phosphate starvation-inducible protein PhoH
BD65_RS14705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BD65_RS14710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BD65_RS14745	COG0367	asparagine synthase
BD65_RS14750	COG0647	UMP catabolic process
BD65_RS14755	COG1846	Transcriptional regulator
BD65_RS14755	COG1940	carbohydrate kinase activity
BD65_RS14760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BD65_RS14770	COG2190	(PTS) system
BD65_RS14770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BD65_RS14770	COG1263	PTS System
BD65_RS14795	COG0735	belongs to the Fur family
BD65_RS14805	COG0840	transmembrane signaling receptor activity
BD65_RS14815	COG0596	Alpha beta hydrolase
BD65_RS14820	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BD65_RS14825	COG0033	Phosphoglucomutase
BD65_RS14835	COG0745	RESPONSE REGULATOR receiver
BD65_RS14840	COG2205	protein histidine kinase activity
BD65_RS14845	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BD65_RS14850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BD65_RS14870	COG3272	Protein of unknown function (DUF1722)
BD65_RS14875	COG0415	Belongs to the DNA photolyase family
BD65_RS14880	COG5212	phosphodiesterase
BD65_RS14885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BD65_RS14890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BD65_RS14895	COG1984	allophanate hydrolase subunit 2
BD65_RS14900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BD65_RS14935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BD65_RS14940	COG1053	succinate dehydrogenase
BD65_RS14945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BD65_RS14950	COG0567	Dehydrogenase, E1 component
BD65_RS14955	COG0508	dehydrogenase complex catalyzes the overall conversion of
BD65_RS14960	COG0045	succinate-CoA ligase (ADP-forming) activity
BD65_RS14965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BD65_RS14970	COG0737	Belongs to the 5'-nucleotidase family
BD65_RS14975	COG1271	oxidase subunit
BD65_RS14980	COG1294	oxidase, subunit
BD65_RS14985	COG4890	Cyd operon protein YbgT
BD65_RS14990	COG3790	cyd operon protein YbgE
BD65_RS14995	COG0824	Thioesterase
BD65_RS15000	COG0811	peptide transport
BD65_RS15005	COG0848	biopolymer transport protein
BD65_RS15010	COG3064	Membrane
BD65_RS15010	COG3064	Membrane
BD65_RS15015	COG0823	Involved in the tonB-independent uptake of proteins
BD65_RS15020	COG2885	chlorophyll binding
BD65_RS15025	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BD65_RS15040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BD65_RS15050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_RS15050	COG2205	protein histidine kinase activity
BD65_RS15060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BD65_RS15065	COG0588	phosphoglycerate mutase activity
BD65_RS15075	COG2017	converts alpha-aldose to the beta-anomer
BD65_RS15085	COG1085	galactose-1-phosphate uridylyltransferase
BD65_RS15090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BD65_RS15100	COG3585	molybdate ion transport
BD65_RS15100	COG2005	Transcriptional regulator
BD65_RS15110	COG0725	ABC transporter, periplasmic molybdate-binding protein
BD65_RS15115	COG4149	molybdate abc transporter
BD65_RS15125	COG0561	phosphatase activity
BD65_RS15130	COG2706	6-phosphogluconolactonase activity
BD65_RS15145	COG0156	8-amino-7-oxononanoate synthase activity
BD65_RS15150	COG2226	methyltransferase
BD65_RS15165	COG0556	nucleotide-excision repair
BD65_RS15170	COG4628	conserved protein (DUF2132)
BD65_RS15185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BD65_RS15190	COG1120	ATPase activity
BD65_RS15195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BD65_RS15200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BD65_RS15210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BD65_RS15215	COG0314	molybdopterin synthase activity
BD65_RS15220	COG0670	Belongs to the BI1 family
BD65_RS15225	COG0842	Transport permease protein
BD65_RS15230	COG0842	Transport permease protein
BD65_RS15235	COG1131	(ABC) transporter
BD65_RS15240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_RS15255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BD65_RS15265	COG1686	Belongs to the peptidase S11 family
BD65_RS15270	COG0277	FAD linked oxidase domain protein
BD65_RS15290	COG2261	transglycosylase associated protein
BD65_RS15300	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BD65_RS15310	COG3639	organic phosphonate transmembrane transporter activity
BD65_RS15315	COG4807	Protein conserved in bacteria
BD65_RS15320	COG2897	thiosulfate sulfurtransferase activity
BD65_RS15325	COG1732	Glycine betaine
BD65_RS15330	COG1174	glycine betaine transport
BD65_RS15335	COG1125	glycine betaine transport
BD65_RS15340	COG1174	glycine betaine transport
BD65_RS15345	COG0531	amino acid
BD65_RS15350	COG1982	Orn Lys Arg decarboxylase major
BD65_RS15355	COG0675	Transposase, IS605 OrfB family
BD65_RS15365	COG0697	spore germination
BD65_RS15380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BD65_RS15385	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
BD65_RS15390	COG1126	abc transporter atp-binding protein
BD65_RS15395	COG0765	amino acid transport
BD65_RS15400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_RS15420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BD65_RS15425	COG2239	Acts as a magnesium transporter
BD65_RS15435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BD65_RS15440	COG0488	(ABC) transporter
BD65_RS15445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BD65_RS15450	COG0303	'Molybdopterin
BD65_RS15470	COG0583	DNA-binding transcription factor activity
BD65_RS15475	COG0477	Major facilitator Superfamily
BD65_RS15480	COG0302	gtp cyclohydrolase
BD65_RS15485	COG2311	Membrane
BD65_RS15510	COG2949	membrane
BD65_RS15515	COG0281	malic enzyme
BD65_RS15535	COG1346	cytolysis
BD65_RS15540	COG1380	Effector of murein hydrolase LrgA
BD65_RS15565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD65_RS15565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BD65_RS15570	COG0489	protein tyrosine kinase activity
BD65_RS15575	COG0572	uridine kinase
BD65_RS15580	COG0717	Belongs to the dCTP deaminase family
BD65_RS15585	COG2982	Protein involved in outer membrane biogenesis
BD65_RS15590	COG3069	C4-dicarboxylate transmembrane transporter activity
BD65_RS15595	COG1253	flavin adenine dinucleotide binding
BD65_RS15600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BD65_RS15605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BD65_RS15610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BD65_RS15615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BD65_RS15615	COG0140	phosphoribosyl-ATP diphosphatase activity
BD65_RS15625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BD65_RS15635	COG0131	Imidazoleglycerol-phosphate dehydratase
BD65_RS15635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BD65_RS15640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BD65_RS15645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BD65_RS15660	COG0675	Transposase, IS605 OrfB family
BD65_RS15665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD65_RS15670	COG0625	glutathione transferase activity
BD65_RS15685	COG0626	cystathionine gamma-synthase activity
BD65_RS15695	COG1686	Belongs to the peptidase S11 family
BD65_RS15700	COG1760	l-serine dehydratase
BD65_RS15705	COG0814	amino acid
BD65_RS15710	COG1349	DNA-binding transcription factor activity
BD65_RS15720	COG0671	phosphoesterase, PA-phosphatase related
BD65_RS15735	COG0569	domain protein
BD65_RS15735	COG2985	domain, Protein
BD65_RS15755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BD65_RS15760	COG3842	ATPase activity
BD65_RS15765	COG1176	ABC-type spermidine putrescine transport system, permease component I
BD65_RS15770	COG1177	transmembrane transport
BD65_RS15785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_RS15790	COG4160	amino acid transport
BD65_RS15795	COG4215	(ABC) transporter
BD65_RS15800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BD65_RS15805	COG1126	abc transporter atp-binding protein
BD65_RS15815	COG0393	Putative heavy-metal-binding
BD65_RS15820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BD65_RS15825	COG0702	epimerase
BD65_RS15830	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BD65_RS15835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BD65_RS15840	COG1151	hydroxylamine reductase activity
BD65_RS15845	COG2431	L-lysine efflux transmembrane transporter activity
BD65_RS15855	COG2990	Protein conserved in bacteria
BD65_RS15860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BD65_RS15870	COG1278	Cold shock
BD65_RS15875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BD65_RS15880	COG0542	response to heat
BD65_RS15885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BD65_RS15895	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BD65_RS15905	COG0492	ferredoxin-NADP+ reductase activity
BD65_RS15910	COG1522	sequence-specific DNA binding
BD65_RS15915	COG1674	ftsk spoiiie
BD65_RS15915	COG3107	peptidoglycan biosynthetic process
BD65_RS15920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BD65_RS15925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BD65_RS15930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BD65_RS15935	COG2814	Major facilitator Superfamily
BD65_RS15940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BD65_RS15945	COG1882	Formate acetyltransferase
BD65_RS15950	COG2116	formate transmembrane transporter activity
BD65_RS15955	COG1944	ATP diphosphatase activity
BD65_RS15960	COG0252	asparaginase activity
BD65_RS15970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BD65_RS15980	COG0539	negative regulation of cytoplasmic translation
BD65_RS15990	COG2333	competence protein COMEC
BD65_RS15990	COG0658	competence protein
BD65_RS16000	COG1663	tetraacyldisaccharide 4'-kinase activity
BD65_RS16005	COG5383	Protein conserved in bacteria
BD65_RS16015	COG1278	Cold shock
BD65_RS16020	COG2835	tetraacyldisaccharide 4'-kinase activity
BD65_RS16030	COG3173	Aminoglycoside phosphotransferase
BD65_RS16035	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BD65_RS16040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BD65_RS16045	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BD65_RS16055	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BD65_RS16060	COG2989	Protein conserved in bacteria
BD65_RS16065	COG3108	Peptidase M15
BD65_RS16070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BD65_RS16075	COG2200	EAL domain
BD65_RS16080	COG1448	Aminotransferase
BD65_RS16100	COG4372	Transposase
BD65_RS16145	COG3210	domain, Protein
BD65_RS16150	COG3210	domain, Protein