locus-tag	class	description
D5F51_RS00005	COG0716	FMN binding
D5F51_RS00010	COG1522	sequence-specific DNA binding
D5F51_RS00015	COG2502	aspartate--ammonia ligase
D5F51_RS00030	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D5F51_RS00035	COG0714	Associated with various cellular activities
D5F51_RS00040	COG3158	transport of potassium into the cell
D5F51_RS00045	COG1869	D-ribose catabolic process
D5F51_RS00050	COG1129	ABC transporter
D5F51_RS00055	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS00060	COG1879	ABC-type sugar transport system periplasmic component
D5F51_RS00065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_RS00070	COG1609	Transcriptional regulator
D5F51_RS00075	COG0477	Major facilitator Superfamily
D5F51_RS00080	COG2186	Transcriptional regulator
D5F51_RS00110	COG1763	Mo-molybdopterin cofactor biosynthetic process
D5F51_RS00120	COG3084	Protein conserved in bacteria
D5F51_RS00125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5F51_RS00130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5F51_RS00135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5F51_RS00135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5F51_RS00140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5F51_RS00145	COG3078	GTPase activator activity
D5F51_RS00155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5F51_RS00165	COG3852	Histidine kinase
D5F51_RS00180	COG1011	Hydrolase
D5F51_RS00185	COG1295	ribonuclease BN
D5F51_RS00190	COG1490	D-aminoacyl-tRNA deacylase activity
D5F51_RS00195	COG0456	acetyltransferase
D5F51_RS00200	COG3423	Transcriptional regulator
D5F51_RS00215	COG2982	Protein involved in outer membrane biogenesis
D5F51_RS00220	COG2233	PERMEase
D5F51_RS00230	COG0786	glutamate:sodium symporter activity
D5F51_RS00235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5F51_RS00240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5F51_RS00245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5F51_RS00250	COG1758	RNA polymerase activity
D5F51_RS00260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5F51_RS00265	COG2860	membrane
D5F51_RS00275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_RS00280	COG1024	Enoyl-CoA hydratase
D5F51_RS00285	COG5001	Diguanylate cyclase
D5F51_RS00290	COG1561	YicC-like family, N-terminal region
D5F51_RS00300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D5F51_RS00305	COG1309	transcriptional regulator
D5F51_RS00310	COG0756	dUTP diphosphatase activity
D5F51_RS00315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5F51_RS00330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5F51_RS00335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5F51_RS00340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5F51_RS00345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5F51_RS00355	COG1519	Transferase
D5F51_RS00360	COG0859	PFAM glycosyl transferase family 9
D5F51_RS00365	COG0859	PFAM glycosyl transferase family 9
D5F51_RS00370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_RS00375	COG0156	8-amino-7-oxononanoate synthase activity
D5F51_RS00385	COG2861	carbohydrate metabolic process
D5F51_RS00390	COG4942	peptidase
D5F51_RS00395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5F51_RS00400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5F51_RS00405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_RS00410	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D5F51_RS00415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5F51_RS00420	COG1045	serine acetyltransferase
D5F51_RS00425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5F51_RS00430	COG2169	Transcriptional regulator
D5F51_RS00430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5F51_RS00435	COG2205	protein histidine kinase activity
D5F51_RS00440	COG0745	RESPONSE REGULATOR receiver
D5F51_RS00445	COG3678	ATP-independent chaperone mediated protein folding
D5F51_RS00450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5F51_RS00465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D5F51_RS00475	COG0149	triose-phosphate isomerase activity
D5F51_RS00485	COG3152	Membrane
D5F51_RS00495	COG2814	Major facilitator Superfamily
D5F51_RS00500	COG1494	fructose-1,6-bisphosphatase
D5F51_RS00510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5F51_RS00525	COG3074	FtsZ-dependent cytokinesis
D5F51_RS00530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5F51_RS00535	COG1575	Belongs to the MenA family. Type 1 subfamily
D5F51_RS00540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5F51_RS00550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5F51_RS00555	COG1609	Transcriptional regulator
D5F51_RS00565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5F51_RS00575	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D5F51_RS00580	COG0626	cystathionine gamma-synthase activity
D5F51_RS00585	COG0460	homoserine dehydrogenase
D5F51_RS00585	COG0527	aspartate kinase activity
D5F51_RS00600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D5F51_RS00620	COG0165	Argininosuccinate lyase
D5F51_RS00665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_RS00670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_RS00670	COG0678	peroxiredoxin activity
D5F51_RS00680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_RS00685	COG1309	transcriptional regulator
D5F51_RS00695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5F51_RS00705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5F51_RS00750	COG1879	ABC-type sugar transport system periplasmic component
D5F51_RS00755	COG1129	ABC transporter
D5F51_RS00760	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS00765	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS00770	COG0583	DNA-binding transcription factor activity
D5F51_RS00775	COG3085	chromosome segregation
D5F51_RS00795	COG3978	acetolactate synthase activity
D5F51_RS00800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5F51_RS00805	COG0129	dihydroxy-acid dehydratase activity
D5F51_RS00810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5F51_RS00815	COG0583	DNA-binding transcription factor activity
D5F51_RS00820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5F51_RS00840	COG3121	Chaperone
D5F51_RS00855	COG3121	Chaperone
D5F51_RS00865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5F51_RS00880	COG0248	Ppx GppA phosphatase
D5F51_RS00890	COG3118	belongs to the thioredoxin family
D5F51_RS00895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5F51_RS00900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5F51_RS00905	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
D5F51_RS00910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D5F51_RS00915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D5F51_RS00920	COG1088	dTDP-glucose 4,6-dehydratase activity
D5F51_RS00925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D5F51_RS00930	COG0456	acetyltransferase
D5F51_RS00935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5F51_RS00940	COG2244	polysaccharide biosynthetic process
D5F51_RS00945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5F51_RS00965	COG1113	amino acid transport
D5F51_RS00990	COG3071	HemY protein
D5F51_RS00995	COG2959	enzyme of heme biosynthesis
D5F51_RS01000	COG1587	Uroporphyrinogen-III synthase
D5F51_RS01005	COG0181	hydroxymethylbilane synthase activity
D5F51_RS01015	COG3072	Adenylate cyclase
D5F51_RS01020	COG1965	Belongs to the frataxin family
D5F51_RS01025	COG5567	small periplasmic lipoprotein
D5F51_RS01030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5F51_RS01035	COG3159	Protein conserved in bacteria
D5F51_RS01040	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5F51_RS01045	COG1011	Hydrolase
D5F51_RS01050	COG0210	DNA helicase
D5F51_RS01065	COG5441	Belongs to the UPF0261 family
D5F51_RS01070	COG5564	TIM-barrel signal transduction protein
D5F51_RS01090	COG2050	protein possibly involved in aromatic compounds catabolism
D5F51_RS01095	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D5F51_RS01100	COG0514	ATP-dependent DNA helicase (RecQ)
D5F51_RS01105	COG1280	lysine exporter protein (LysE YggA)
D5F51_RS01110	COG1280	lysine exporter protein (LysE YggA)
D5F51_RS01115	COG2267	carboxylic ester hydrolase activity
D5F51_RS01120	COG0561	phosphatase activity
D5F51_RS01125	COG0584	glycerophosphoryl diester phosphodiesterase
D5F51_RS01130	COG2271	Major facilitator Superfamily
D5F51_RS01135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5F51_RS01145	COG0247	lactate metabolic process
D5F51_RS01155	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D5F51_RS01160	COG0425	Belongs to the sulfur carrier protein TusA family
D5F51_RS01170	COG3714	YhhN family
D5F51_RS01185	COG3776	membrane
D5F51_RS01190	COG0742	ribosomal rna small subunit methyltransferase
D5F51_RS01195	COG0552	protein localization to endoplasmic reticulum
D5F51_RS01200	COG2884	Cell division ATP-binding protein ftsE
D5F51_RS01205	COG2177	Part of the ABC transporter FtsEX involved in
D5F51_RS01215	COG0456	acetyltransferase
D5F51_RS01220	COG0683	leucine binding
D5F51_RS01230	COG4177	L-phenylalanine transmembrane transporter activity
D5F51_RS01240	COG0410	ABC transporter
D5F51_RS01290	COG1653	transport
D5F51_RS01295	COG1175	transmembrane transport
D5F51_RS01300	COG0395	ABC-type sugar transport system, permease component
D5F51_RS01305	COG3842	ATPase activity
D5F51_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
D5F51_RS01315	COG0679	Auxin Efflux Carrier
D5F51_RS01320	COG0697	spore germination
D5F51_RS01325	COG0583	DNA-binding transcription factor activity
D5F51_RS01330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5F51_RS01335	COG0412	Dienelactone hydrolase
D5F51_RS01350	COG1966	Carbon starvation protein
D5F51_RS01355	COG0586	Pfam SNARE associated Golgi protein
D5F51_RS01360	COG1322	Protein conserved in bacteria
D5F51_RS01365	COG2226	methyltransferase
D5F51_RS01375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5F51_RS01380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5F51_RS01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5F51_RS01390	COG0805	protein transport
D5F51_RS01410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D5F51_RS01420	COG0183	Belongs to the thiolase family
D5F51_RS01425	COG1024	Enoyl-CoA hydratase
D5F51_RS01425	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5F51_RS01435	COG1739	Uncharacterized protein family UPF0029
D5F51_RS01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5F51_RS01485	COG1072	(Pantothenic acid kinase))
D5F51_RS01525	COG0250	Participates in transcription elongation, termination and antitermination
D5F51_RS01530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5F51_RS01545	COG0222	ribosome binding
D5F51_RS01550	COG0085	RNA polymerase activity
D5F51_RS01555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5F51_RS01565	COG2022	thiamine diphosphate biosynthetic process
D5F51_RS01570	COG2104	thiamine diphosphate biosynthetic process
D5F51_RS01575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5F51_RS01590	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D5F51_RS01595	COG2816	NAD+ diphosphatase activity
D5F51_RS01600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5F51_RS01605	COG1515	deoxyribonuclease V activity
D5F51_RS01625	COG0151	Belongs to the GarS family
D5F51_RS01630	COG0138	bifunctional purine biosynthesis protein purh
D5F51_RS01670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5F51_RS01675	COG3162	membrane
D5F51_RS01680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5F51_RS01685	COG1301	dicarboxylic acid transport
D5F51_RS01850	COG2391	methyltransferase activity
D5F51_RS01855	COG0425	Belongs to the sulfur carrier protein TusA family
D5F51_RS01860	COG1196	nuclear chromosome segregation
D5F51_RS01860	COG3264	Mechanosensitive ion channel
D5F51_RS01865	COG4774	siderophore transport
D5F51_RS01885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_RS01890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D5F51_RS01895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_RS01900	COG4558	Periplasmic binding protein
D5F51_RS01905	COG3720	iron ion transport
D5F51_RS01925	COG3721	Heme iron utilization protein
D5F51_RS01955	COG1309	transcriptional regulator
D5F51_RS01965	COG3836	Belongs to the HpcH HpaI aldolase family
D5F51_RS01970	COG2084	Dehydrogenase
D5F51_RS01975	COG1929	Belongs to the glycerate kinase type-1 family
D5F51_RS01980	COG3835	regulator
D5F51_RS01985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_RS01985	COG0493	'glutamate synthase
D5F51_RS01990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_RS01995	COG3383	formate dehydrogenase (NAD+) activity
D5F51_RS02000	COG4232	protein-disulfide reductase activity
D5F51_RS02010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D5F51_RS02025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5F51_RS02030	COG0459	protein refolding
D5F51_RS02050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5F51_RS02065	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D5F51_RS02070	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D5F51_RS02075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5F51_RS02080	COG1053	succinate dehydrogenase
D5F51_RS02085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D5F51_RS02090	COG1511	domain protein
D5F51_RS02090	COG3264	Mechanosensitive ion channel
D5F51_RS02095	COG0688	phosphatidylethanolamine metabolic process
D5F51_RS02100	COG1162	GTPase activity
D5F51_RS02105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D5F51_RS02125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D5F51_RS02130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D5F51_RS02130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D5F51_RS02135	COG0802	atpase or kinase
D5F51_RS02140	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5F51_RS02145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5F51_RS02150	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5F51_RS02155	COG1923	regulation of RNA biosynthetic process
D5F51_RS02160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5F51_RS02165	COG0330	HflC and HflK could
D5F51_RS02170	COG0330	HflC and HflK could
D5F51_RS02180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D5F51_RS02185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5F51_RS02190	COG1959	2 iron, 2 sulfur cluster binding
D5F51_RS02195	COG0557	exoribonuclease II activity
D5F51_RS02200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5F51_RS02205	COG1960	acyl-CoA dehydrogenase activity
D5F51_RS02210	COG3650	response to hydrogen peroxide
D5F51_RS02215	COG1073	alpha beta
D5F51_RS02230	COG0360	Binds together with S18 to 16S ribosomal RNA
D5F51_RS02235	COG2965	DNA replication, synthesis of RNA primer
D5F51_RS02240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D5F51_RS02245	COG0359	binds to the 23S rRNA
D5F51_RS02255	COG3061	Opacity-associated protein A
D5F51_RS02260	COG0545	Peptidyl-prolyl cis-trans isomerase
D5F51_RS02270	COG0737	Belongs to the 5'-nucleotidase family
D5F51_RS02275	COG1218	3'(2'),5'-bisphosphate nucleotidase
D5F51_RS02280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D5F51_RS02290	COG1253	flavin adenine dinucleotide binding
D5F51_RS02295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5F51_RS02300	COG0729	surface antigen
D5F51_RS02310	COG2105	PFAM AIG2 family protein
D5F51_RS02315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5F51_RS02320	COG0840	transmembrane signaling receptor activity
D5F51_RS02325	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D5F51_RS02330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5F51_RS02340	COG1438	arginine binding
D5F51_RS02345	COG0039	L-malate dehydrogenase activity
D5F51_RS02350	COG3423	Transcriptional regulator
D5F51_RS02360	COG0142	geranyltranstransferase activity
D5F51_RS02375	COG0697	spore germination
D5F51_RS02380	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5F51_RS02385	COG0642	Histidine kinase
D5F51_RS02390	COG0745	RESPONSE REGULATOR receiver
D5F51_RS02395	COG2027	D-alanyl-D-alanine carboxypeptidase
D5F51_RS02405	COG1534	Rna-binding protein
D5F51_RS02410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5F51_RS02420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5F51_RS02430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5F51_RS02450	COG0195	Participates in both transcription termination and antitermination
D5F51_RS02460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5F51_RS02465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5F51_RS02475	COG1185	polyribonucleotide nucleotidyltransferase activity
D5F51_RS02490	COG0513	Belongs to the DEAD box helicase family
D5F51_RS02495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5F51_RS02515	COG0826	peptidase U32
D5F51_RS02520	COG0826	peptidase U32
D5F51_RS02525	COG3154	lipid carrier protein
D5F51_RS02530	COG3153	acetyltransferase
D5F51_RS02540	COG0531	amino acid
D5F51_RS02545	COG1982	Orn Lys Arg decarboxylase major
D5F51_RS02565	COG1653	transport
D5F51_RS02570	COG1175	transmembrane transport
D5F51_RS02575	COG0395	ABC-type sugar transport system, permease component
D5F51_RS02580	COG3842	ATPase activity
D5F51_RS02590	COG3787	Belongs to the UPF0306 family
D5F51_RS02595	COG0702	epimerase
D5F51_RS02600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5F51_RS02605	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D5F51_RS02610	COG3454	Phosphonate metabolism
D5F51_RS02615	COG4778	phosphonate C-P lyase system protein PhnL
D5F51_RS02620	COG4107	phosphonate C-P lyase system protein PhnK
D5F51_RS02625	COG3627	carbon phosphorus lyase activity
D5F51_RS02630	COG3626	phosphonate metabolism
D5F51_RS02640	COG3624	Phosphonate C-P lyase system protein PhnG
D5F51_RS02645	COG2188	Transcriptional regulator
D5F51_RS02660	COG0602	queuosine metabolic process
D5F51_RS02670	COG0583	DNA-binding transcription factor activity
D5F51_RS02675	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5F51_RS02680	COG4608	Belongs to the ABC transporter superfamily
D5F51_RS02685	COG0444	Belongs to the ABC transporter superfamily
D5F51_RS02690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_RS02695	COG0601	transmembrane transport
D5F51_RS02705	COG2731	YhcH YjgK YiaL family protein
D5F51_RS02715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D5F51_RS02735	COG2927	DNA polymerase III (CHI subunit)
D5F51_RS02740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5F51_RS02745	COG0795	lipopolysaccharide-transporting ATPase activity
D5F51_RS02750	COG0795	lipopolysaccharide-transporting ATPase activity
D5F51_RS02760	COG0582	viral genome integration into host DNA
D5F51_RS02770	COG3328	transposase activity
D5F51_RS02800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5F51_RS02860	COG3596	GTP binding
D5F51_RS02870	COG2378	regulation of single-species biofilm formation
D5F51_RS02900	COG2003	Belongs to the UPF0758 family
D5F51_RS02925	COG0454	-acetyltransferase
D5F51_RS02950	COG3272	Protein of unknown function (DUF1722)
D5F51_RS02955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D5F51_RS02960	COG1830	Aldolase
D5F51_RS02965	COG1879	ABC-type sugar transport system periplasmic component
D5F51_RS02970	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS02975	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS02980	COG1129	ABC transporter
D5F51_RS02990	COG2390	Transcriptional regulator
D5F51_RS02995	COG1070	Carbohydrate kinase
D5F51_RS03000	COG0859	PFAM glycosyl transferase family 9
D5F51_RS03015	COG2235	arginine
D5F51_RS03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS03030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_RS03040	COG2376	Dihydroxyacetone kinase
D5F51_RS03045	COG1461	Dihydroxyacetone kinase
D5F51_RS03050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5F51_RS03050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS03050	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D5F51_RS03060	COG2192	nodulation
D5F51_RS03135	COG0667	Aldo Keto reductase
D5F51_RS03140	COG2813	Specifically methylates the guanine in position
D5F51_RS03145	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D5F51_RS03155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5F51_RS03160	COG2823	Periplasmic or secreted lipoprotein
D5F51_RS03170	COG4667	esterase of the alpha-beta hydrolase superfamily
D5F51_RS03175	COG0084	hydrolase, TatD family'
D5F51_RS03180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_RS03195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D5F51_RS03200	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5F51_RS03210	COG3726	membrane protein affecting hemolysin expression
D5F51_RS03215	COG0560	Phosphoserine phosphatase
D5F51_RS03230	COG0604	alcohol dehydrogenase
D5F51_RS03240	COG0488	(ABC) transporter
D5F51_RS03245	COG0582	viral genome integration into host DNA
D5F51_RS03290	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D5F51_RS03295	COG5532	Uncharacterized conserved protein (DUF2303)
D5F51_RS03335	COG4626	Terminase
D5F51_RS03335	COG1802	Transcriptional regulator
D5F51_RS03355	COG1403	HNH endonuclease
D5F51_RS03390	COG3179	chitinase
D5F51_RS03520	COG2885	chlorophyll binding
D5F51_RS03525	COG2199	diguanylate cyclase activity
D5F51_RS03535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5F51_RS03540	COG0741	lytic transglycosylase activity
D5F51_RS03545	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D5F51_RS03550	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D5F51_RS03555	COG0406	alpha-ribazole phosphatase activity
D5F51_RS03560	COG3708	Transcriptional regulator
D5F51_RS03560	COG2207	Transcriptional regulator
D5F51_RS03565	COG3045	CreA protein
D5F51_RS03570	COG0745	RESPONSE REGULATOR receiver
D5F51_RS03585	COG0083	homoserine kinase activity
D5F51_RS03595	COG3022	response to hydroperoxide
D5F51_RS03605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5F51_RS03610	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5F51_RS03625	COG1584	GPR1 FUN34 yaaH family protein
D5F51_RS03635	COG0484	heat shock protein binding
D5F51_RS03640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D5F51_RS03645	COG0583	DNA-binding transcription factor activity
D5F51_RS03665	COG0196	riboflavin kinase activity
D5F51_RS03670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5F51_RS03675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5F51_RS03680	COG1047	Peptidyl-prolyl cis-trans
D5F51_RS03685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5F51_RS03690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5F51_RS03700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5F51_RS03705	COG1280	lysine exporter protein (LysE YggA)
D5F51_RS03710	COG2966	Psort location CytoplasmicMembrane, score
D5F51_RS03715	COG3610	response to peptide
D5F51_RS03720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5F51_RS03725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5F51_RS03730	COG2967	ApaG domain
D5F51_RS03740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5F51_RS03750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5F51_RS03755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5F51_RS03765	COG0564	pseudouridine synthase activity
D5F51_RS03770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5F51_RS03775	COG0417	DNA replication proofreading
D5F51_RS03780	COG0586	Pfam SNARE associated Golgi protein
D5F51_RS03790	COG1178	ABC-type Fe3 transport system permease component
D5F51_RS03795	COG4143	(ABC) transporter
D5F51_RS03800	COG4533	DNA binding
D5F51_RS03805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5F51_RS03810	COG1882	Formate acetyltransferase
D5F51_RS03815	COG2814	Major facilitator Superfamily
D5F51_RS03820	COG0814	amino acid
D5F51_RS03825	COG3033	Beta-eliminating lyase
D5F51_RS03840	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5F51_RS03845	COG0473	3-isopropylmalate dehydrogenase activity
D5F51_RS03850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5F51_RS03865	COG1022	Amp-dependent synthetase and ligase
D5F51_RS03870	COG0028	Belongs to the TPP enzyme family
D5F51_RS03895	COG0275	rRNA processing
D5F51_RS03900	COG3116	cell division
D5F51_RS03905	COG0768	penicillin binding
D5F51_RS03910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5F51_RS03915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5F51_RS03920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5F51_RS03930	COG0772	Belongs to the SEDS family
D5F51_RS03935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5F51_RS03940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5F51_RS03950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5F51_RS03955	COG0849	cell division
D5F51_RS03960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5F51_RS03980	COG0653	protein targeting
D5F51_RS03985	COG0494	nUDIX hydrolase
D5F51_RS03990	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5F51_RS04010	COG0516	GMP reductase activity
D5F51_RS04020	COG3328	transposase activity
D5F51_RS04030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_RS04035	COG4969	Belongs to the N-Me-Phe pilin family
D5F51_RS04045	COG3023	N-Acetylmuramoyl-L-alanine amidase
D5F51_RS04050	COG3725	Membrane protein required for beta-lactamase induction
D5F51_RS04120	COG4386	tail sheath protein
D5F51_RS04145	COG4397	Mu-like prophage major head subunit gpT
D5F51_RS04175	COG4383	Mu-like prophage protein gp29
D5F51_RS04215	COG3179	chitinase
D5F51_RS04230	COG4382	Mu-like prophage protein Gp16
D5F51_RS04310	COG3423	Transcriptional regulator
D5F51_RS04325	COG3328	transposase activity
D5F51_RS04330	COG1113	amino acid transport
D5F51_RS04335	COG2186	Transcriptional regulator
D5F51_RS04345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D5F51_RS04350	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5F51_RS04355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_RS04375	COG1049	propionate catabolic process, 2-methylcitrate cycle
D5F51_RS04380	COG3112	Uncharacterised protein family (UPF0231)
D5F51_RS04385	COG0697	spore germination
D5F51_RS04395	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5F51_RS04405	COG2132	Multicopper oxidase
D5F51_RS04410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D5F51_RS04415	COG0288	reversible hydration of carbon dioxide
D5F51_RS04420	COG1131	(ABC) transporter
D5F51_RS04425	COG0842	Transport permease protein
D5F51_RS04430	COG0726	polysaccharide deacetylase
D5F51_RS04435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D5F51_RS04440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5F51_RS04445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D5F51_RS04450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5F51_RS04455	COG0617	tRNA 3'-terminal CCA addition
D5F51_RS04460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5F51_RS04475	COG1489	DNA binding
D5F51_RS04480	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5F51_RS04485	COG1643	Atp-dependent helicase
D5F51_RS04490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5F51_RS04495	COG1120	ATPase activity
D5F51_RS04500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5F51_RS04505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_RS04510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5F51_RS04520	COG0316	Belongs to the HesB IscA family
D5F51_RS04530	COG2860	membrane
D5F51_RS04540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5F51_RS04545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D5F51_RS04550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5F51_RS04555	COG3437	response regulator, receiver
D5F51_RS04555	COG3850	Histidine kinase
D5F51_RS04555	COG4999	Histidine kinase
D5F51_RS04555	COG2205	protein histidine kinase activity
D5F51_RS04560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5F51_RS04565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5F51_RS04570	COG3956	TIGRFAM MazG family protein
D5F51_RS04575	COG0504	CTP synthase activity
D5F51_RS04580	COG0148	phosphopyruvate hydratase activity
D5F51_RS04590	COG0602	queuosine metabolic process
D5F51_RS04595	COG0720	synthase
D5F51_RS04600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5F51_RS04605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5F51_RS04610	COG0175	sulfate reduction
D5F51_RS04615	COG2234	aminopeptidase activity
D5F51_RS04620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_RS04620	COG1648	precorrin-2 dehydrogenase activity
D5F51_RS04625	COG0175	sulfate reduction
D5F51_RS04630	COG2895	sulfate adenylyltransferase (ATP) activity
D5F51_RS04635	COG0529	Catalyzes the synthesis of activated sulfate
D5F51_RS04650	COG0765	amino acid transport
D5F51_RS04660	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5F51_RS04670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5F51_RS04675	COG0585	pseudouridine synthase activity
D5F51_RS04680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5F51_RS04685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5F51_RS04690	COG4942	peptidase
D5F51_RS04690	COG1388	LysM domain
D5F51_RS04695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5F51_RS04700	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5F51_RS04715	COG0288	reversible hydration of carbon dioxide
D5F51_RS04720	COG0786	glutamate:sodium symporter activity
D5F51_RS04745	COG3210	domain, Protein
D5F51_RS04780	COG2831	hemolysin activation secretion protein
D5F51_RS04790	COG2365	Tyrosine phosphatase family
D5F51_RS04795	COG3328	transposase activity
D5F51_RS04800	COG0582	viral genome integration into host DNA
D5F51_RS04820	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5F51_RS04825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5F51_RS04830	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5F51_RS04835	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5F51_RS04840	COG1138	Cytochrome C-type biogenesis protein
D5F51_RS04845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5F51_RS04855	COG4235	cytochrome complex assembly
D5F51_RS04855	COG3088	subunit of a heme lyase
D5F51_RS04870	COG3691	Protein conserved in bacteria
D5F51_RS04875	COG0183	Belongs to the thiolase family
D5F51_RS04880	COG1024	Enoyl-CoA hydratase
D5F51_RS04880	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5F51_RS04885	COG2062	phosphohistidine phosphatase, SixA
D5F51_RS04890	COG2840	Smr protein MutS2
D5F51_RS04895	COG2890	protein-(glutamine-N5) methyltransferase activity
D5F51_RS04900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5F51_RS04905	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D5F51_RS04910	COG0730	response to heat
D5F51_RS04915	COG3101	peptidyl-lysine hydroxylation
D5F51_RS04925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D5F51_RS04925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5F51_RS04930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5F51_RS04940	COG1794	racemase activity, acting on amino acids and derivatives
D5F51_RS04950	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5F51_RS04955	COG2723	6-phospho-beta-galactosidase activity
D5F51_RS04960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5F51_RS04980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5F51_RS05005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5F51_RS05010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_RS05020	COG0697	spore germination
D5F51_RS05030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5F51_RS05035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5F51_RS05045	COG0586	Pfam SNARE associated Golgi protein
D5F51_RS05050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5F51_RS05055	COG0285	dihydrofolate synthase activity
D5F51_RS05060	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D5F51_RS05065	COG1286	toxin biosynthetic process
D5F51_RS05070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5F51_RS05085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS05090	COG4215	(ABC) transporter
D5F51_RS05095	COG4160	amino acid transport
D5F51_RS05100	COG4598	ABC transporter
D5F51_RS05105	COG1090	epimerase
D5F51_RS05115	COG0622	Phosphoesterase
D5F51_RS05120	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D5F51_RS05125	COG3037	sugar-specific permease SgaT UlaA
D5F51_RS05135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS05140	COG1609	Transcriptional regulator
D5F51_RS05145	COG0857	belongs to the CobB CobQ family
D5F51_RS05145	COG0280	phosphate acetyltransferase
D5F51_RS05155	COG3092	negative regulation of chromosome organization
D5F51_RS05160	COG3013	Belongs to the UPF0304 family
D5F51_RS05165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_RS05175	COG0490	domain, Protein
D5F51_RS05175	COG0471	metal ion transport
D5F51_RS05180	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D5F51_RS05185	COG0436	Aminotransferase
D5F51_RS05190	COG0583	DNA-binding transcription factor activity
D5F51_RS05195	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS05200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS05205	COG0649	NAD binding
D5F51_RS05205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS05220	COG1034	ATP synthesis coupled electron transport
D5F51_RS05225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5F51_RS05230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS05235	COG0839	Belongs to the complex I subunit 6 family
D5F51_RS05240	COG0713	ATP synthesis coupled electron transport
D5F51_RS05245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5F51_RS05250	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS05255	COG1007	ATP synthesis coupled electron transport
D5F51_RS05280	COG3265	gluconokinase activity
D5F51_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS05290	COG1609	Transcriptional regulator
D5F51_RS05295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5F51_RS05305	COG4702	Belongs to the UPF0303 family
D5F51_RS05315	COG4575	ribosome binding
D5F51_RS05320	COG1169	isochorismate synthase
D5F51_RS05325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D5F51_RS05330	COG0596	Alpha beta hydrolase
D5F51_RS05335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D5F51_RS05340	COG1441	menaquinone biosynthetic process
D5F51_RS05360	COG0814	amino acid
D5F51_RS05370	COG4574	serine-type endopeptidase inhibitor activity
D5F51_RS05375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_RS05385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5F51_RS05390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5F51_RS05400	COG0784	Response regulator, receiver
D5F51_RS05400	COG2205	protein histidine kinase activity
D5F51_RS05410	COG2198	Histidine kinase
D5F51_RS05410	COG0642	Histidine kinase
D5F51_RS05415	COG2223	nitrite transmembrane transporter activity
D5F51_RS05420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D5F51_RS05435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5F51_RS05465	COG1263	PTS System
D5F51_RS05465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS05465	COG2190	(PTS) system
D5F51_RS05470	COG2723	6-phospho-beta-galactosidase activity
D5F51_RS05495	COG3082	Protein of unknown function (DUF1414)
D5F51_RS05500	COG3081	Nucleoid-associated protein
D5F51_RS05510	COG1061	Type III restriction enzyme res subunit
D5F51_RS05515	COG1187	pseudouridine synthase activity
D5F51_RS05520	COG2814	Major facilitator Superfamily
D5F51_RS05530	COG4172	Belongs to the ABC transporter superfamily
D5F51_RS05535	COG4239	(ABC) transporter, permease
D5F51_RS05540	COG4174	ABC transporter (Permease)
D5F51_RS05545	COG4166	transmembrane transport
D5F51_RS05550	COG2200	EAL domain
D5F51_RS05560	COG0791	NLP P60 protein
D5F51_RS05565	COG0671	phosphoesterase, PA-phosphatase related
D5F51_RS05570	COG0523	cobalamin synthesis protein
D5F51_RS05580	COG2186	Transcriptional regulator
D5F51_RS05585	COG0246	Mannitol dehydrogenase
D5F51_RS05600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5F51_RS05625	COG1105	Belongs to the carbohydrate kinase PfkB family
D5F51_RS05630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5F51_RS05630	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D5F51_RS05630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5F51_RS05635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D5F51_RS05640	COG2855	membrane
D5F51_RS05650	COG0583	DNA-binding transcription factor activity
D5F51_RS05655	COG0833	amino acid
D5F51_RS05660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_RS05670	COG4771	TonB-dependent receptor
D5F51_RS05675	COG0625	glutathione transferase activity
D5F51_RS05710	COG2011	ABC-type metal ion transport system permease component
D5F51_RS05715	COG0626	cystathionine gamma-synthase activity
D5F51_RS05725	COG1686	Belongs to the peptidase S11 family
D5F51_RS05730	COG1760	l-serine dehydratase
D5F51_RS05735	COG0814	amino acid
D5F51_RS05740	COG1349	DNA-binding transcription factor activity
D5F51_RS05745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5F51_RS05750	COG0671	phosphoesterase, PA-phosphatase related
D5F51_RS05760	COG2985	domain, Protein
D5F51_RS05760	COG0569	domain protein
D5F51_RS05780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D5F51_RS05785	COG3842	ATPase activity
D5F51_RS05790	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5F51_RS05795	COG1177	transmembrane transport
D5F51_RS05805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5F51_RS05810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS05820	COG4160	amino acid transport
D5F51_RS05825	COG4215	(ABC) transporter
D5F51_RS05830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS05835	COG1126	abc transporter atp-binding protein
D5F51_RS05850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_RS05855	COG0702	epimerase
D5F51_RS05860	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D5F51_RS05865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D5F51_RS05870	COG0028	Belongs to the TPP enzyme family
D5F51_RS05875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_RS05880	COG1151	hydroxylamine reductase activity
D5F51_RS05885	COG2431	L-lysine efflux transmembrane transporter activity
D5F51_RS05890	COG3593	DNA synthesis involved in DNA repair
D5F51_RS05895	COG2990	Protein conserved in bacteria
D5F51_RS05900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS05910	COG1278	Cold shock
D5F51_RS05915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5F51_RS05920	COG0542	response to heat
D5F51_RS05925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5F51_RS05930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5F51_RS05935	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D5F51_RS05945	COG0492	ferredoxin-NADP+ reductase activity
D5F51_RS05955	COG3107	peptidoglycan biosynthetic process
D5F51_RS05955	COG1674	ftsk spoiiie
D5F51_RS05960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5F51_RS05965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5F51_RS05975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5F51_RS05980	COG2814	Major facilitator Superfamily
D5F51_RS05985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5F51_RS05990	COG1882	Formate acetyltransferase
D5F51_RS05995	COG2116	formate transmembrane transporter activity
D5F51_RS06000	COG1944	ATP diphosphatase activity
D5F51_RS06005	COG0252	asparaginase activity
D5F51_RS06010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5F51_RS06015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5F51_RS06020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5F51_RS06025	COG0539	negative regulation of cytoplasmic translation
D5F51_RS06030	COG0776	regulation of translation
D5F51_RS06035	COG2333	competence protein COMEC
D5F51_RS06035	COG0658	competence protein
D5F51_RS06045	COG1663	tetraacyldisaccharide 4'-kinase activity
D5F51_RS06050	COG5383	Protein conserved in bacteria
D5F51_RS06065	COG2835	tetraacyldisaccharide 4'-kinase activity
D5F51_RS06070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5F51_RS06075	COG3173	Aminoglycoside phosphotransferase
D5F51_RS06080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D5F51_RS06085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5F51_RS06090	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D5F51_RS06100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D5F51_RS06105	COG2989	Protein conserved in bacteria
D5F51_RS06110	COG3108	Peptidase M15
D5F51_RS06115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5F51_RS06120	COG2200	EAL domain
D5F51_RS06125	COG1448	Aminotransferase
D5F51_RS06135	COG0017	Asparaginyl-tRNA synthetase
D5F51_RS06140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D5F51_RS06145	COG3866	Pectate lyase
D5F51_RS06150	COG0308	aminopeptidase N
D5F51_RS06155	COG0167	dihydroorotate dehydrogenase activity
D5F51_RS06165	COG0633	Ferredoxin
D5F51_RS06165	COG3217	Mosc domain protein beta barrel domain protein
D5F51_RS06170	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5F51_RS06170	COG0116	Belongs to the methyltransferase superfamily
D5F51_RS06175	COG0488	(ABC) transporter
D5F51_RS06180	COG2995	paraquat-inducible protein a
D5F51_RS06185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5F51_RS06185	COG3008	intermembrane lipid transfer
D5F51_RS06190	COG3009	Protein conserved in bacteria
D5F51_RS06195	COG3130	regulation of translation
D5F51_RS06200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5F51_RS06210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5F51_RS06215	COG1067	ATP-dependent peptidase activity
D5F51_RS06220	COG3120	sequence-specific DNA binding
D5F51_RS06230	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
D5F51_RS06235	COG3070	regulator of competence-specific genes
D5F51_RS06240	COG1289	transmembrane transporter activity
D5F51_RS06245	COG3304	Inner membrane component domain
D5F51_RS06250	COG0210	DNA helicase
D5F51_RS06255	COG1803	Methylglyoxal synthase
D5F51_RS06265	COG1832	CoA-binding protein
D5F51_RS06270	COG3785	DNA binding
D5F51_RS06275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5F51_RS06290	COG1254	Belongs to the acylphosphatase family
D5F51_RS06295	COG2920	part of a sulfur-relay system
D5F51_RS06305	COG2771	luxR family
D5F51_RS06310	COG3916	Acyl-homoserine-lactone synthase
D5F51_RS06320	COG3263	regulation of cellular component size
D5F51_RS06335	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D5F51_RS06340	COG2943	transferase activity, transferring hexosyl groups
D5F51_RS06345	COG5645	(Lipo)protein
D5F51_RS06360	COG2814	Major facilitator Superfamily
D5F51_RS06365	COG2259	Doxx family
D5F51_RS06370	COG1560	Kdo2-lipid A biosynthetic process
D5F51_RS06385	COG0628	permease
D5F51_RS06415	COG0418	dihydroorotase activity
D5F51_RS06420	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D5F51_RS06425	COG1530	ribonuclease E activity
D5F51_RS06425	COG1530	ribonuclease E activity
D5F51_RS06435	COG0564	pseudouridine synthase activity
D5F51_RS06440	COG0424	maF-like protein
D5F51_RS06445	COG1399	metal-binding, possibly nucleic acid-binding protein
D5F51_RS06450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5F51_RS06455	COG0416	fatty acid biosynthetic process
D5F51_RS06465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5F51_RS06480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5F51_RS06485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5F51_RS06490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5F51_RS06495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5F51_RS06500	COG0470	DNA polymerase III
D5F51_RS06505	COG0084	hydrolase, TatD family'
D5F51_RS06510	COG1263	PTS System
D5F51_RS06510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS06520	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5F51_RS06525	COG0537	adenosine 5'-monophosphoramidase activity
D5F51_RS06530	COG5633	Lipoprotein
D5F51_RS06535	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
D5F51_RS06540	COG0510	thiamine kinase activity
D5F51_RS06545	COG1472	Belongs to the glycosyl hydrolase 3 family
D5F51_RS06550	COG3150	esterase
D5F51_RS06555	COG1252	NADH dehydrogenase
D5F51_RS06560	COG3134	Outer membrane lipoprotein
D5F51_RS06565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5F51_RS06570	COG4591	ABC-type transport system involved in lipoprotein release permease component
D5F51_RS06580	COG4591	ABC-type transport system involved in lipoprotein release permease component
D5F51_RS06585	COG1940	carbohydrate kinase activity
D5F51_RS06600	COG2850	peptidyl-arginine hydroxylation
D5F51_RS06610	COG0745	RESPONSE REGULATOR receiver
D5F51_RS06620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5F51_RS06625	COG2915	High frequency lysogenization protein hflD homolog
D5F51_RS06630	COG0482	sulfurtransferase activity
D5F51_RS06640	COG1187	pseudouridine synthase activity
D5F51_RS06645	COG0538	isocitrate dehydrogenase activity
D5F51_RS06680	COG0840	transmembrane signaling receptor activity
D5F51_RS06690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5F51_RS06700	COG2873	o-acetylhomoserine
D5F51_RS06705	COG0702	epimerase
D5F51_RS06710	COG1733	regulation of RNA biosynthetic process
D5F51_RS06725	COG2721	sulfolactate sulfo-lyase activity
D5F51_RS06730	COG0246	Mannitol dehydrogenase
D5F51_RS06735	COG1063	alcohol dehydrogenase
D5F51_RS06740	COG1802	Transcriptional regulator
D5F51_RS06745	COG4948	Mandelate Racemase Muconate Lactonizing
D5F51_RS06750	COG2271	Major facilitator Superfamily
D5F51_RS06755	COG0697	spore germination
D5F51_RS06765	COG3755	Protein conserved in bacteria
D5F51_RS06780	COG5001	Diguanylate cyclase
D5F51_RS06780	COG4251	negative regulation of phosphorylation
D5F51_RS06780	COG3706	GGDEF domain
D5F51_RS06780	COG2203	Gaf domain
D5F51_RS06790	COG1132	(ABC) transporter
D5F51_RS06810	COG2207	Transcriptional regulator
D5F51_RS06845	COG1113	amino acid transport
D5F51_RS06865	COG1496	oxidoreductase activity
D5F51_RS06870	COG0768	penicillin binding
D5F51_RS06875	COG2226	methyltransferase
D5F51_RS06885	COG3447	MASE1 domain protein
D5F51_RS06885	COG5001	Diguanylate cyclase
D5F51_RS06885	COG5002	protein histidine kinase activity
D5F51_RS06895	COG1971	Probably functions as a manganese efflux pump
D5F51_RS06900	COG4811	Protein of unknown function (DUF986)
D5F51_RS06905	COG3716	PTS system mannose fructose sorbose family IID component
D5F51_RS06910	COG3715	PTS system
D5F51_RS06915	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS06915	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS06920	COG1253	flavin adenine dinucleotide binding
D5F51_RS06930	COG1760	l-serine dehydratase
D5F51_RS06935	COG0494	nUDIX hydrolase
D5F51_RS06945	COG3140	Belongs to the UPF0181 family
D5F51_RS06950	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D5F51_RS06955	COG0513	Belongs to the DEAD box helicase family
D5F51_RS06960	COG3141	response to X-ray
D5F51_RS06965	COG3097	Belongs to the UPF0267 family
D5F51_RS06975	COG1770	oligopeptidase
D5F51_RS06980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5F51_RS06995	COG1528	Iron-storage protein
D5F51_RS07000	COG2372	response to copper ion
D5F51_RS07005	COG1276	copper resistance
D5F51_RS07015	COG0582	viral genome integration into host DNA
D5F51_RS07055	COG1396	sequence-specific DNA binding
D5F51_RS07130	COG3081	Nucleoid-associated protein
D5F51_RS07140	COG3772	lysozyme
D5F51_RS07160	COG1475	DNA binding
D5F51_RS07195	COG3567	Phage-associated protein, HI1409 family
D5F51_RS07205	COG3566	protein conserved in bacteria
D5F51_RS07320	COG2755	lipolytic protein G-D-S-L family
D5F51_RS07320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_RS07460	COG1187	pseudouridine synthase activity
D5F51_RS07485	COG0625	glutathione transferase activity
D5F51_RS07510	COG2203	Gaf domain
D5F51_RS07510	COG4251	negative regulation of phosphorylation
D5F51_RS07510	COG5001	Diguanylate cyclase
D5F51_RS07510	COG3706	GGDEF domain
D5F51_RS07545	COG2814	Major facilitator Superfamily
D5F51_RS07555	COG3008	intermembrane lipid transfer
D5F51_RS07560	COG2995	paraquat-inducible protein a
D5F51_RS07565	COG1956	GAF domain-containing protein
D5F51_RS07575	COG0793	Belongs to the peptidase S41A family
D5F51_RS07580	COG0501	Belongs to the peptidase M48B family
D5F51_RS07585	COG2814	Major facilitator Superfamily
D5F51_RS07590	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_RS07600	COG3023	N-Acetylmuramoyl-L-alanine amidase
D5F51_RS07605	COG1823	symporter activity
D5F51_RS07610	COG1988	membrane-bound metal-dependent
D5F51_RS07615	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5F51_RS07625	COG3842	ATPase activity
D5F51_RS07630	COG0395	ABC-type sugar transport system, permease component
D5F51_RS07635	COG1175	transmembrane transport
D5F51_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS07650	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D5F51_RS07655	COG1917	Cupin 2, conserved barrel domain protein
D5F51_RS07660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_RS07670	COG0583	DNA-binding transcription factor activity
D5F51_RS07675	COG0427	acetyl-CoA hydrolase
D5F51_RS07680	COG1024	Enoyl-CoA hydratase
D5F51_RS07685	COG1703	isobutyryl-CoA mutase activity
D5F51_RS07690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5F51_RS07690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5F51_RS07695	COG3001	Fructosamine kinase
D5F51_RS07700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_RS07705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_RS07710	COG1121	(ABC) transporter
D5F51_RS07715	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5F51_RS07750	COG1811	Na channel or pump
D5F51_RS07755	COG4249	Peptidase C14 caspase catalytic subunit p20
D5F51_RS07760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5F51_RS07765	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5F51_RS07775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5F51_RS07795	COG0776	regulation of translation
D5F51_RS07800	COG2314	TM2 domain
D5F51_RS07810	COG4139	cobalamin transport
D5F51_RS07815	COG0386	Belongs to the glutathione peroxidase family
D5F51_RS07820	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D5F51_RS07825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5F51_RS07830	COG0463	Glycosyl transferase, family 2
D5F51_RS07840	COG0726	polysaccharide deacetylase
D5F51_RS07845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D5F51_RS07850	COG2076	Multidrug Resistance protein
D5F51_RS07855	COG2076	Multidrug Resistance protein
D5F51_RS07860	COG0791	NLP P60 protein
D5F51_RS07865	COG0095	Lipoate-protein ligase
D5F51_RS07875	COG4558	Periplasmic binding protein
D5F51_RS07880	COG3720	iron ion transport
D5F51_RS07885	COG4771	TonB-dependent receptor
D5F51_RS07900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5F51_RS07905	COG0574	Belongs to the PEP-utilizing enzyme family
D5F51_RS07905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5F51_RS07915	COG0628	permease
D5F51_RS07920	COG0247	lactate metabolic process
D5F51_RS07920	COG0277	FAD linked oxidase domain protein
D5F51_RS07925	COG2050	protein possibly involved in aromatic compounds catabolism
D5F51_RS07935	COG0316	Belongs to the HesB IscA family
D5F51_RS07940	COG0719	Fe-S assembly protein
D5F51_RS07945	COG0396	ATPase activity
D5F51_RS07950	COG0719	Fe-S assembly protein
D5F51_RS07960	COG2166	iron-sulfur cluster assembly
D5F51_RS07965	COG1376	ErfK ybiS ycfS ynhG family protein
D5F51_RS07965	COG1388	LysM domain
D5F51_RS07995	COG0534	Mate efflux family protein
D5F51_RS08000	COG0307	riboflavin synthase, alpha
D5F51_RS08005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D5F51_RS08010	COG2814	Major facilitator Superfamily
D5F51_RS08015	COG0583	DNA-binding transcription factor activity
D5F51_RS08020	COG1609	Transcriptional regulator
D5F51_RS08035	COG0791	NLP P60 protein
D5F51_RS08040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D5F51_RS08045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5F51_RS08050	COG0346	lactoylglutathione lyase activity
D5F51_RS08055	COG1902	pentaerythritol trinitrate reductase activity
D5F51_RS08060	COG1309	transcriptional regulator
D5F51_RS08065	COG2194	sulfuric ester hydrolase activity
D5F51_RS08070	COG3313	Fe-S protein
D5F51_RS08075	COG4989	oxidoreductase activity
D5F51_RS08080	COG1289	transmembrane transporter activity
D5F51_RS08085	COG1566	PFAM secretion protein HlyD family protein
D5F51_RS08095	COG1846	Transcriptional regulator
D5F51_RS08100	COG3133	Outer membrane lipoprotein
D5F51_RS08105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D5F51_RS08110	COG3895	Periplasmic Protein
D5F51_RS08115	COG0259	pyridoxamine-phosphate oxidase activity
D5F51_RS08120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5F51_RS08130	COG0625	glutathione transferase activity
D5F51_RS08150	COG3104	oligopeptide transport
D5F51_RS08160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5F51_RS08160	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5F51_RS08195	COG3121	Chaperone
D5F51_RS08200	COG3188	usher protein
D5F51_RS08205	COG4172	Belongs to the ABC transporter superfamily
D5F51_RS08215	COG4171	peptide transport system, permease
D5F51_RS08235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D5F51_RS08240	COG1842	Phage shock protein A
D5F51_RS08250	COG1983	PspC domain protein
D5F51_RS08260	COG3106	COG3106 Predicted ATPase
D5F51_RS08265	COG3768	UPF0283 membrane protein
D5F51_RS08270	COG5654	RES domain protein
D5F51_RS08275	COG5642	Protein of unknown function (DUF2384)
D5F51_RS08285	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D5F51_RS08290	COG4948	Mandelate Racemase Muconate Lactonizing
D5F51_RS08295	COG2866	Carboxypeptidase
D5F51_RS08300	COG4166	transmembrane transport
D5F51_RS08320	COG0037	tRNA processing
D5F51_RS08325	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_RS08335	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5F51_RS08335	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D5F51_RS08335	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5F51_RS08335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS08350	COG3042	response to heat
D5F51_RS08355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5F51_RS08360	COG2911	Protein conserved in bacteria
D5F51_RS08370	COG3784	Protein of unknown function (DUF1318)
D5F51_RS08380	COG1070	Carbohydrate kinase
D5F51_RS08385	COG0246	Mannitol dehydrogenase
D5F51_RS08390	COG2390	Transcriptional regulator
D5F51_RS08395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5F51_RS08400	COG1643	Atp-dependent helicase
D5F51_RS08405	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
D5F51_RS08415	COG3591	Belongs to the peptidase S1B family
D5F51_RS08425	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D5F51_RS08430	COG2205	protein histidine kinase activity
D5F51_RS08435	COG0745	RESPONSE REGULATOR receiver
D5F51_RS08445	COG0531	amino acid
D5F51_RS08460	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D5F51_RS08465	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D5F51_RS08470	COG0589	response to stress
D5F51_RS08475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5F51_RS08480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5F51_RS08495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D5F51_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS08515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_RS08520	COG0738	Major facilitator superfamily
D5F51_RS08535	COG0583	DNA-binding transcription factor activity
D5F51_RS08545	COG1011	Hydrolase
D5F51_RS08555	COG0440	acetolactate synthase activity
D5F51_RS08560	COG0028	Belongs to the TPP enzyme family
D5F51_RS08580	COG3121	Chaperone
D5F51_RS08585	COG3188	usher protein
D5F51_RS08595	COG2831	hemolysin activation secretion protein
D5F51_RS08600	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_RS08600	COG3210	domain, Protein
D5F51_RS08600	COG3064	Membrane
D5F51_RS08600	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_RS08600	COG3210	domain, Protein
D5F51_RS08600	COG3064	Membrane
D5F51_RS08605	COG3710	Transcriptional regulator
D5F51_RS08615	COG2197	response regulator
D5F51_RS08640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5F51_RS08675	COG1522	sequence-specific DNA binding
D5F51_RS08685	COG0625	glutathione transferase activity
D5F51_RS08715	COG0477	Major facilitator Superfamily
D5F51_RS08720	COG4221	oxidoreductase activity
D5F51_RS08725	COG1742	UPF0060 membrane protein
D5F51_RS08750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D5F51_RS08755	COG1940	carbohydrate kinase activity
D5F51_RS08760	COG0583	DNA-binding transcription factor activity
D5F51_RS08765	COG2814	Major facilitator Superfamily
D5F51_RS08785	COG2020	methyltransferase activity
D5F51_RS08790	COG0114	fumarate hydratase activity
D5F51_RS08800	COG5339	Protein conserved in bacteria
D5F51_RS08805	COG1609	Transcriptional regulator
D5F51_RS08810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS08810	COG1263	PTS System
D5F51_RS08815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5F51_RS08820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D5F51_RS08825	COG0385	Bile acid
D5F51_RS08830	COG0673	inositol 2-dehydrogenase activity
D5F51_RS08840	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS08845	COG1129	ABC transporter
D5F51_RS08850	COG1879	ABC-type sugar transport system periplasmic component
D5F51_RS08860	COG2160	L-arabinose isomerase activity
D5F51_RS08865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5F51_RS08870	COG2274	protein secretion by the type I secretion system
D5F51_RS08875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS08890	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D5F51_RS08900	COG4657	Part of a membrane complex involved in electron transport
D5F51_RS08910	COG4656	Part of a membrane complex involved in electron transport
D5F51_RS08915	COG2207	Transcriptional regulator
D5F51_RS08915	COG3708	Transcriptional regulator
D5F51_RS08920	COG4658	electron transport chain
D5F51_RS08925	COG4659	FMN binding
D5F51_RS08935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5F51_RS08945	COG0243	molybdopterin cofactor binding
D5F51_RS08950	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D5F51_RS08955	COG1966	Carbon starvation protein
D5F51_RS08960	COG2879	small protein
D5F51_RS08965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5F51_RS08970	COG1349	DNA-binding transcription factor activity
D5F51_RS08980	COG0235	Class ii aldolase
D5F51_RS08990	COG0023	Translation Initiation Factor
D5F51_RS08995	COG0284	orotidine-5'-phosphate decarboxylase activity
D5F51_RS09005	COG3135	benzoate transporter
D5F51_RS09010	COG1396	sequence-specific DNA binding
D5F51_RS09020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D5F51_RS09025	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D5F51_RS09030	COG0671	phosphoesterase, PA-phosphatase related
D5F51_RS09040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5F51_RS09055	COG0583	DNA-binding transcription factor activity
D5F51_RS09075	COG0616	signal peptide processing
D5F51_RS09080	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS09085	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D5F51_RS09090	COG1187	pseudouridine synthase activity
D5F51_RS09110	COG2197	response regulator
D5F51_RS09120	COG0009	L-threonylcarbamoyladenylate synthase
D5F51_RS09125	COG0613	PHP domain protein
D5F51_RS09140	COG0512	Glutamine amidotransferase of anthranilate synthase
D5F51_RS09150	COG0135	phosphoribosylanthranilate isomerase activity
D5F51_RS09150	COG0134	indole-3-glycerol-phosphate synthase activity
D5F51_RS09155	COG0133	tryptophan synthase activity
D5F51_RS09160	COG0159	tryptophan synthase activity
D5F51_RS09170	COG3047	cAMP biosynthetic process
D5F51_RS09190	COG2917	probably involved in intracellular septation
D5F51_RS09200	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D5F51_RS09205	COG2350	Protein conserved in bacteria
D5F51_RS09230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5F51_RS09240	COG4608	Belongs to the ABC transporter superfamily
D5F51_RS09245	COG0444	Belongs to the ABC transporter superfamily
D5F51_RS09250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_RS09270	COG2095	MarC family integral membrane protein
D5F51_RS09280	COG1012	belongs to the aldehyde dehydrogenase family
D5F51_RS09280	COG1454	alcohol dehydrogenase
D5F51_RS09295	COG2916	Histone family protein nucleoid-structuring protein H-NS
D5F51_RS09305	COG0745	RESPONSE REGULATOR receiver
D5F51_RS09310	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5F51_RS09315	COG3012	SEC-C Motif Domain Protein
D5F51_RS09320	COG0788	formyltetrahydrofolate deformylase activity
D5F51_RS09350	COG0708	Exodeoxyribonuclease III
D5F51_RS09355	COG0494	nUDIX hydrolase
D5F51_RS09365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5F51_RS09375	COG0778	Nitroreductase
D5F51_RS09380	COG0616	signal peptide processing
D5F51_RS09385	COG0252	asparaginase activity
D5F51_RS09390	COG1335	isochorismatase
D5F51_RS09395	COG3139	Protein of unknown function (DUF1315)
D5F51_RS09415	COG3713	MltA-interacting MipA family protein
D5F51_RS09425	COG2766	serine protein kinase
D5F51_RS09430	COG2718	Belongs to the UPF0229 family
D5F51_RS09445	COG0583	DNA-binding transcription factor activity
D5F51_RS09455	COG2199	diguanylate cyclase activity
D5F51_RS09455	COG2200	EAL domain
D5F51_RS09455	COG2202	Pas domain
D5F51_RS09460	COG2814	Major facilitator Superfamily
D5F51_RS09465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5F51_RS09470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5F51_RS09475	COG2719	SpoVR family
D5F51_RS09480	COG2186	Transcriptional regulator
D5F51_RS09485	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D5F51_RS09490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5F51_RS09500	COG2983	Belongs to the UPF0260 family
D5F51_RS09505	COG0179	Fumarylacetoacetate (FAA) hydrolase
D5F51_RS09510	COG2951	lytic endotransglycosylase activity
D5F51_RS09525	COG0850	regulation of cytokinetic process
D5F51_RS09530	COG2894	cell division
D5F51_RS09535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D5F51_RS09540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D5F51_RS09545	COG0318	PFAM AMP-dependent synthetase and ligase
D5F51_RS09550	COG3065	identical protein binding
D5F51_RS09560	COG1199	ATP-dependent helicase activity
D5F51_RS09565	COG0251	oxidation-reduction process
D5F51_RS09570	COG2076	Multidrug Resistance protein
D5F51_RS09575	COG2076	Multidrug Resistance protein
D5F51_RS09580	COG0800	Aldolase
D5F51_RS09585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5F51_RS09590	COG1737	Transcriptional regulator
D5F51_RS09595	COG0469	pyruvate kinase activity
D5F51_RS09600	COG1560	Kdo2-lipid A biosynthetic process
D5F51_RS09605	COG0739	heme binding
D5F51_RS09610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D5F51_RS09615	COG1121	(ABC) transporter
D5F51_RS09620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_RS09625	COG3104	oligopeptide transport
D5F51_RS09630	COG2255	four-way junction helicase activity
D5F51_RS09645	COG0217	transcriptional regulatory protein
D5F51_RS09650	COG0494	nUDIX hydrolase
D5F51_RS09655	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5F51_RS09665	COG1335	isochorismatase
D5F51_RS09670	COG1801	Protein of unknown function DUF72
D5F51_RS09675	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D5F51_RS09685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5F51_RS09690	COG3142	Participates in the control of copper homeostasis
D5F51_RS09695	COG3102	Protein conserved in bacteria
D5F51_RS09700	COG0018	arginyl-trna synthetase
D5F51_RS09705	COG0728	peptidoglycan biosynthetic process
D5F51_RS09710	COG0673	inositol 2-dehydrogenase activity
D5F51_RS09720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5F51_RS09725	COG0477	Major facilitator Superfamily
D5F51_RS09735	COG3381	protein complex oligomerization
D5F51_RS09740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5F51_RS09745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5F51_RS09765	COG0659	secondary active sulfate transmembrane transporter activity
D5F51_RS09770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5F51_RS09785	COG2890	protein-(glutamine-N5) methyltransferase activity
D5F51_RS09790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5F51_RS09795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D5F51_RS09800	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D5F51_RS09810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5F51_RS09820	COG0193	aminoacyl-tRNA hydrolase activity
D5F51_RS09830	COG0012	GTP binding
D5F51_RS09850	COG4942	peptidase
D5F51_RS09860	COG3443	Belongs to the bacterial solute-binding protein 9 family
D5F51_RS09865	COG4211	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS09870	COG1129	ABC transporter
D5F51_RS09885	COG0402	S-adenosylhomocysteine deaminase activity
D5F51_RS09895	COG1228	amidohydrolase
D5F51_RS09910	COG2988	succinylglutamate desuccinylase activity
D5F51_RS09915	COG3724	N-succinylarginine dihydrolase activity
D5F51_RS09925	COG3138	arginine N-succinyltransferase
D5F51_RS09930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5F51_RS09940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_RS09945	COG1271	oxidase subunit
D5F51_RS09950	COG1294	oxidase, subunit
D5F51_RS09960	COG3850	Histidine kinase
D5F51_RS09965	COG0583	DNA-binding transcription factor activity
D5F51_RS09975	COG0387	Pfam Sodium calcium exchanger
D5F51_RS09980	COG1702	phosphate starvation-inducible protein PhoH
D5F51_RS09995	COG3658	cytochrome
D5F51_RS10000	COG1215	transferase activity, transferring glycosyl groups
D5F51_RS10005	COG1649	PFAM Uncharacterised BCR, COG1649
D5F51_RS10005	COG0726	polysaccharide deacetylase
D5F51_RS10010	COG0457	Tetratricopeptide repeat
D5F51_RS10015	COG0006	proline dipeptidase activity
D5F51_RS10040	COG1136	(ABC) transporter
D5F51_RS10040	COG0577	efflux transmembrane transporter activity
D5F51_RS10050	COG0577	efflux transmembrane transporter activity
D5F51_RS10050	COG1136	(ABC) transporter
D5F51_RS10065	COG0672	)-iron permease
D5F51_RS10085	COG2066	Belongs to the glutaminase family
D5F51_RS10090	COG3622	Belongs to the hyi family
D5F51_RS10095	COG0235	Class ii aldolase
D5F51_RS10100	COG3395	kinase activity
D5F51_RS10105	COG1349	DNA-binding transcription factor activity
D5F51_RS10110	COG3290	protein histidine kinase activity
D5F51_RS10115	COG4565	transcriptional regulatory protein
D5F51_RS10120	COG3493	citrate carrier protein
D5F51_RS10135	COG0346	lactoylglutathione lyase activity
D5F51_RS10145	COG2223	nitrite transmembrane transporter activity
D5F51_RS10150	COG0561	phosphatase activity
D5F51_RS10160	COG3122	Protein conserved in bacteria
D5F51_RS10175	COG0456	acetyltransferase
D5F51_RS10195	COG3328	transposase activity
D5F51_RS10220	COG4974	Belongs to the 'phage' integrase family
D5F51_RS10280	COG4695	Portal protein
D5F51_RS10440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5F51_RS10445	COG0322	excinuclease ABC activity
D5F51_RS10450	COG2197	response regulator
D5F51_RS10460	COG3136	membrane protein required for alginate biosynthesis
D5F51_RS10470	COG0366	Alpha amylase catalytic
D5F51_RS10485	COG2226	methyltransferase
D5F51_RS10510	COG1113	amino acid transport
D5F51_RS10520	COG1881	PFAM PEBP family protein
D5F51_RS10525	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D5F51_RS10555	COG2822	iron ion transport
D5F51_RS10560	COG0672	)-iron permease
D5F51_RS10570	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D5F51_RS10570	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D5F51_RS10570	COG0506	proline dehydrogenase activity
D5F51_RS10585	COG1126	abc transporter atp-binding protein
D5F51_RS10590	COG0765	amino acid transport
D5F51_RS10595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS10600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D5F51_RS10610	COG1191	sigma factor activity
D5F51_RS10640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5F51_RS10660	COG1677	Flagellar hook-basal body complex protein FliE
D5F51_RS10675	COG1317	bacterial-type flagellum organization
D5F51_RS10680	COG1157	protein secretion by the type III secretion system
D5F51_RS10685	COG2882	bacterial-type flagellum organization
D5F51_RS10695	COG1580	Controls the rotational direction of flagella during chemotaxis
D5F51_RS10715	COG1338	Plays a role in the flagellum-specific transport system
D5F51_RS10730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5F51_RS10735	COG1256	bacterial-type flagellum assembly
D5F51_RS10765	COG1749	Flagellar hook protein flgE
D5F51_RS10770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5F51_RS10775	COG1558	bacterial-type flagellum-dependent cell motility
D5F51_RS10780	COG1815	bacterial-type flagellum-dependent cell motility
D5F51_RS10790	COG2747	anti-sigma28 factor FlgM
D5F51_RS10795	COG3418	PFAM FlgN family protein
D5F51_RS10805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5F51_RS10810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5F51_RS10815	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D5F51_RS10820	COG0745	RESPONSE REGULATOR receiver
D5F51_RS10830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5F51_RS10835	COG0840	transmembrane signaling receptor activity
D5F51_RS10840	COG0840	transmembrane signaling receptor activity
D5F51_RS10845	COG0835	chemotaxis
D5F51_RS10850	COG0643	Histidine kinase
D5F51_RS10850	COG2198	Histidine kinase
D5F51_RS10855	COG1360	Flagellar Motor Protein
D5F51_RS10875	COG0589	response to stress
D5F51_RS10885	COG1285	pathogenesis
D5F51_RS10890	COG0840	transmembrane signaling receptor activity
D5F51_RS10905	COG1609	Transcriptional regulator
D5F51_RS10910	COG3250	beta-galactosidase activity
D5F51_RS10925	COG1522	sequence-specific DNA binding
D5F51_RS10945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5F51_RS10955	COG2453	phosphatase
D5F51_RS10955	COG0671	phosphoesterase, PA-phosphatase related
D5F51_RS10960	COG2267	carboxylic ester hydrolase activity
D5F51_RS10970	COG4589	Belongs to the CDS family
D5F51_RS10975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5F51_RS10985	COG2197	response regulator
D5F51_RS11010	COG3228	Belongs to the MtfA family
D5F51_RS11020	COG0582	viral genome integration into host DNA
D5F51_RS11025	COG1121	(ABC) transporter
D5F51_RS11040	COG3328	transposase activity
D5F51_RS11055	COG2814	Major facilitator Superfamily
D5F51_RS11065	COG0667	Aldo Keto reductase
D5F51_RS11075	COG5002	protein histidine kinase activity
D5F51_RS11110	COG1396	sequence-specific DNA binding
D5F51_RS11125	COG0656	L-ascorbic acid biosynthetic process
D5F51_RS11130	COG0667	Aldo Keto reductase
D5F51_RS11140	COG0702	epimerase
D5F51_RS11155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS11155	COG2205	protein histidine kinase activity
D5F51_RS11165	COG3121	Chaperone
D5F51_RS11215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5F51_RS11230	COG0471	metal ion transport
D5F51_RS11240	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D5F51_RS11240	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D5F51_RS11245	COG3051	citrate lyase alpha subunit
D5F51_RS11250	COG2301	Belongs to the HpcH HpaI aldolase family
D5F51_RS11255	COG3052	prosthetic group binding
D5F51_RS11260	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D5F51_RS11265	COG3290	protein histidine kinase activity
D5F51_RS11270	COG4565	transcriptional regulatory protein
D5F51_RS11285	COG2271	Major facilitator Superfamily
D5F51_RS11290	COG1840	ABC-type Fe3 transport system, periplasmic component
D5F51_RS11300	COG3842	ATPase activity
D5F51_RS11310	COG0784	Response regulator, receiver
D5F51_RS11310	COG0835	chemotaxis
D5F51_RS11315	COG0534	Mate efflux family protein
D5F51_RS11320	COG0137	argininosuccinate synthase activity
D5F51_RS11325	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D5F51_RS11345	COG1492	cobalamin metabolic process
D5F51_RS11410	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D5F51_RS11420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D5F51_RS11480	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5F51_RS11495	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
D5F51_RS11515	COG4656	Part of a membrane complex involved in electron transport
D5F51_RS11535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5F51_RS11540	COG1648	precorrin-2 dehydrogenase activity
D5F51_RS11540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_RS11545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5F51_RS11560	COG1129	ABC transporter
D5F51_RS11565	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS11580	COG1289	transmembrane transporter activity
D5F51_RS11585	COG3320	Male sterility
D5F51_RS11585	COG1022	Amp-dependent synthetase and ligase
D5F51_RS11590	COG2925	Exonuclease
D5F51_RS11595	COG0531	amino acid
D5F51_RS11605	COG0371	Dehydrogenase
D5F51_RS11610	COG1129	ABC transporter
D5F51_RS11615	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS11620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_RS11630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5F51_RS11640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5F51_RS11645	COG0131	Imidazoleglycerol-phosphate dehydratase
D5F51_RS11645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5F51_RS11655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5F51_RS11660	COG0107	imidazoleglycerol-phosphate synthase activity
D5F51_RS11665	COG0140	phosphoribosyl-ATP diphosphatase activity
D5F51_RS11665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5F51_RS11675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5F51_RS11680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5F51_RS11700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5F51_RS11715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_RS11765	COG1253	flavin adenine dinucleotide binding
D5F51_RS11770	COG3069	C4-dicarboxylate transmembrane transporter activity
D5F51_RS11775	COG2982	Protein involved in outer membrane biogenesis
D5F51_RS11790	COG0489	protein tyrosine kinase activity
D5F51_RS11795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5F51_RS11795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5F51_RS11815	COG2814	Major facilitator Superfamily
D5F51_RS11820	COG1380	Effector of murein hydrolase LrgA
D5F51_RS11825	COG1346	cytolysis
D5F51_RS11835	COG0281	malic enzyme
D5F51_RS11845	COG2949	membrane
D5F51_RS11850	COG0298	carbon dioxide binding
D5F51_RS11855	COG0375	protein maturation
D5F51_RS11860	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_RS11865	COG0651	ATP synthesis coupled electron transport
D5F51_RS11870	COG0650	Formate hydrogenlyase subunit 4
D5F51_RS11875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5F51_RS11880	COG4237	Hydrogenase 4 membrane
D5F51_RS11885	COG0651	ATP synthesis coupled electron transport
D5F51_RS11890	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D5F51_RS11890	COG3261	NADH dehydrogenase
D5F51_RS11895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5F51_RS11900	COG3260	NADH ubiquinone oxidoreductase 20
D5F51_RS11910	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5F51_RS11915	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_RS11920	COG3383	formate dehydrogenase (NAD+) activity
D5F51_RS11930	COG2116	formate transmembrane transporter activity
D5F51_RS11955	COG2311	Membrane
D5F51_RS11960	COG0302	gtp cyclohydrolase
D5F51_RS11965	COG0477	Major facilitator Superfamily
D5F51_RS11970	COG0583	DNA-binding transcription factor activity
D5F51_RS12000	COG1136	(ABC) transporter
D5F51_RS12000	COG0577	efflux transmembrane transporter activity
D5F51_RS12010	COG0477	Major facilitator Superfamily
D5F51_RS12020	COG0303	'Molybdopterin
D5F51_RS12025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5F51_RS12030	COG3397	chitin binding
D5F51_RS12035	COG0488	(ABC) transporter
D5F51_RS12055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D5F51_RS12070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D5F51_RS12085	COG4106	trans-aconitate 2-methyltransferase activity
D5F51_RS12090	COG0783	Belongs to the Dps family
D5F51_RS12095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5F51_RS12100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS12105	COG0765	amino acid transport
D5F51_RS12110	COG1126	abc transporter atp-binding protein
D5F51_RS12120	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D5F51_RS12125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5F51_RS12140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5F51_RS12145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5F51_RS12165	COG0697	spore germination
D5F51_RS12185	COG1174	glycine betaine transport
D5F51_RS12190	COG1125	glycine betaine transport
D5F51_RS12195	COG1174	glycine betaine transport
D5F51_RS12200	COG1732	Glycine betaine
D5F51_RS12210	COG0673	inositol 2-dehydrogenase activity
D5F51_RS12215	COG2897	thiosulfate sulfurtransferase activity
D5F51_RS12220	COG0410	ABC transporter
D5F51_RS12225	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5F51_RS12245	COG4807	Protein conserved in bacteria
D5F51_RS12270	COG2261	transglycosylase associated protein
D5F51_RS12290	COG0277	FAD linked oxidase domain protein
D5F51_RS12295	COG1686	Belongs to the peptidase S11 family
D5F51_RS12305	COG2239	Acts as a magnesium transporter
D5F51_RS12315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5F51_RS12320	COG0513	Belongs to the DEAD box helicase family
D5F51_RS12325	COG1309	transcriptional regulator
D5F51_RS12330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS12335	COG1131	(ABC) transporter
D5F51_RS12340	COG0842	Transport permease protein
D5F51_RS12345	COG0842	Transport permease protein
D5F51_RS12350	COG0670	Belongs to the BI1 family
D5F51_RS12355	COG0314	molybdopterin synthase activity
D5F51_RS12360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5F51_RS12365	COG0315	cyclic pyranopterin monophosphate synthase activity
D5F51_RS12370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5F51_RS12375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5F51_RS12380	COG4628	conserved protein (DUF2132)
D5F51_RS12385	COG0556	nucleotide-excision repair
D5F51_RS12400	COG2226	methyltransferase
D5F51_RS12405	COG0156	8-amino-7-oxononanoate synthase activity
D5F51_RS12410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5F51_RS12420	COG2706	6-phosphogluconolactonase activity
D5F51_RS12435	COG0561	phosphatase activity
D5F51_RS12445	COG4149	molybdate abc transporter
D5F51_RS12450	COG0725	ABC transporter, periplasmic molybdate-binding protein
D5F51_RS12460	COG2005	Transcriptional regulator
D5F51_RS12460	COG3585	molybdate ion transport
D5F51_RS12465	COG1119	ATPase activity
D5F51_RS12475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5F51_RS12485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5F51_RS12490	COG2017	converts alpha-aldose to the beta-anomer
D5F51_RS12500	COG0588	phosphoglycerate mutase activity
D5F51_RS12505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D5F51_RS12510	COG1230	cation diffusion facilitator family transporter
D5F51_RS12520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5F51_RS12555	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D5F51_RS12560	COG2885	chlorophyll binding
D5F51_RS12565	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_RS12570	COG3064	Membrane
D5F51_RS12570	COG3064	Membrane
D5F51_RS12575	COG0848	biopolymer transport protein
D5F51_RS12580	COG0811	peptide transport
D5F51_RS12585	COG0824	Thioesterase
D5F51_RS12590	COG3790	cyd operon protein YbgE
D5F51_RS12595	COG4890	Cyd operon protein YbgT
D5F51_RS12600	COG1294	oxidase, subunit
D5F51_RS12605	COG1271	oxidase subunit
D5F51_RS12610	COG0737	Belongs to the 5'-nucleotidase family
D5F51_RS12615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5F51_RS12625	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5F51_RS12630	COG0567	Dehydrogenase, E1 component
D5F51_RS12640	COG1053	succinate dehydrogenase
D5F51_RS12645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D5F51_RS12650	COG2009	succinate dehydrogenase
D5F51_RS12660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D5F51_RS12675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D5F51_RS12680	COG1984	allophanate hydrolase subunit 2
D5F51_RS12685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D5F51_RS12690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5F51_RS12695	COG5212	phosphodiesterase
D5F51_RS12705	COG3272	Protein of unknown function (DUF1722)
D5F51_RS12725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D5F51_RS12730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D5F51_RS12735	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D5F51_RS12740	COG2205	protein histidine kinase activity
D5F51_RS12745	COG0745	RESPONSE REGULATOR receiver
D5F51_RS12755	COG0033	Phosphoglucomutase
D5F51_RS12760	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D5F51_RS12765	COG0596	Alpha beta hydrolase
D5F51_RS12775	COG0840	transmembrane signaling receptor activity
D5F51_RS12785	COG0735	belongs to the Fur family
D5F51_RS12805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5F51_RS12810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS12810	COG2190	(PTS) system
D5F51_RS12810	COG1263	PTS System
D5F51_RS12815	COG0363	glucosamine-6-phosphate deaminase activity
D5F51_RS12820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5F51_RS12825	COG1846	Transcriptional regulator
D5F51_RS12825	COG1940	carbohydrate kinase activity
D5F51_RS12830	COG0647	UMP catabolic process
D5F51_RS12835	COG0367	asparagine synthase
D5F51_RS12870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5F51_RS12875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5F51_RS12880	COG1702	phosphate starvation-inducible protein PhoH
D5F51_RS12885	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5F51_RS12890	COG4535	Mg2 and Co2 transporter CorC
D5F51_RS12895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5F51_RS12910	COG0765	amino acid transport
D5F51_RS12915	COG0765	amino acid transport
D5F51_RS12920	COG1126	abc transporter atp-binding protein
D5F51_RS12930	COG2888	peptidyl-tyrosine sulfation
D5F51_RS12935	COG0495	leucyl-tRNA aminoacylation
D5F51_RS12940	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D5F51_RS12945	COG1466	dna polymerase III delta subunit
D5F51_RS12950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5F51_RS12955	COG0799	negative regulation of ribosome biogenesis
D5F51_RS12965	COG0768	penicillin binding
D5F51_RS12970	COG0772	Belongs to the SEDS family
D5F51_RS12975	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5F51_RS12980	COG1686	Belongs to the peptidase S11 family
D5F51_RS12985	COG2921	Belongs to the UPF0250 family
D5F51_RS12990	COG0321	lipoyl(octanoyl) transferase activity
D5F51_RS12995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5F51_RS13000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5F51_RS13005	COG3706	GGDEF domain
D5F51_RS13020	COG1278	Cold shock
D5F51_RS13025	COG2197	response regulator
D5F51_RS13035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5F51_RS13055	COG5265	(ABC) transporter
D5F51_RS13060	COG2850	peptidyl-arginine hydroxylation
D5F51_RS13110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5F51_RS13335	COG0582	viral genome integration into host DNA
D5F51_RS13345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5F51_RS13350	COG2501	S4 domain
D5F51_RS13355	COG0215	cysteine-tRNA ligase activity
D5F51_RS13360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5F51_RS13365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_RS13370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D5F51_RS13375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5F51_RS13380	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D5F51_RS13385	COG4181	ATPase activity
D5F51_RS13390	COG2755	lipolytic protein G-D-S-L family
D5F51_RS13395	COG0300	oxidoreductase activity
D5F51_RS13400	COG3118	belongs to the thioredoxin family
D5F51_RS13405	COG0330	HflC and HflK could
D5F51_RS13410	COG1585	Membrane protein implicated in regulation of membrane protease activity
D5F51_RS13415	COG0789	Transcriptional regulator
D5F51_RS13420	COG2217	Heavy metal translocating P-type atpase
D5F51_RS13425	COG3735	TraB family
D5F51_RS13430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D5F51_RS13435	COG0737	Belongs to the 5'-nucleotidase family
D5F51_RS13440	COG2223	nitrite transmembrane transporter activity
D5F51_RS13445	COG4651	solute:proton antiporter activity
D5F51_RS13445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5F51_RS13450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_RS13470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5F51_RS13475	COG0438	transferase activity, transferring glycosyl groups
D5F51_RS13480	COG0438	transferase activity, transferring glycosyl groups
D5F51_RS13485	COG1215	transferase activity, transferring glycosyl groups
D5F51_RS13490	COG1216	Glycosyl transferase, family 2
D5F51_RS13490	COG1442	glycosyl transferase family 8
D5F51_RS13495	COG2244	polysaccharide biosynthetic process
D5F51_RS13500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5F51_RS13505	COG0563	adenylate kinase activity
D5F51_RS13510	COG0326	Molecular chaperone. Has ATPase activity
D5F51_RS13515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5F51_RS13525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D5F51_RS13530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5F51_RS13535	COG2832	Protein of unknown function (DUF454)
D5F51_RS13550	COG1196	nuclear chromosome segregation
D5F51_RS13550	COG3264	Mechanosensitive ion channel
D5F51_RS13555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D5F51_RS13560	COG1309	transcriptional regulator
D5F51_RS13565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS13570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_RS13580	COG3457	Alanine racemase
D5F51_RS13585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5F51_RS13590	COG0254	rRNA binding
D5F51_RS13595	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5F51_RS13600	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5F51_RS13605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5F51_RS13610	COG1121	(ABC) transporter
D5F51_RS13630	COG1388	LysM domain
D5F51_RS13630	COG1470	cell adhesion involved in biofilm formation
D5F51_RS13640	COG3695	enzyme binding
D5F51_RS13645	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D5F51_RS13650	COG1946	Acyl-CoA thioesterase
D5F51_RS13655	COG0004	ammonium transporteR
D5F51_RS13660	COG0347	Belongs to the P(II) protein family
D5F51_RS13665	COG1132	(ABC) transporter
D5F51_RS13670	COG1132	(ABC) transporter
D5F51_RS13675	COG1522	sequence-specific DNA binding
D5F51_RS13685	COG0561	phosphatase activity
D5F51_RS13690	COG4533	DNA binding
D5F51_RS13695	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D5F51_RS13700	COG0824	Thioesterase
D5F51_RS13705	COG1555	photosystem II stabilization
D5F51_RS13710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5F51_RS13715	COG0776	regulation of translation
D5F51_RS13720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5F51_RS13725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5F51_RS13735	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5F51_RS13745	COG0271	Belongs to the BolA IbaG family
D5F51_RS13750	COG3056	Lipoprotein
D5F51_RS13755	COG2223	nitrite transmembrane transporter activity
D5F51_RS13765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5F51_RS13770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5F51_RS13775	COG1845	cytochrome c oxidase, subunit III
D5F51_RS13780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D5F51_RS13785	COG0109	protoheme IX farnesyltransferase activity
D5F51_RS13790	COG2814	Major facilitator Superfamily
D5F51_RS13795	COG1666	GTP binding
D5F51_RS13800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5F51_RS13805	COG0693	protein deglycase activity
D5F51_RS13830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5F51_RS13830	COG0301	tRNA thio-modification
D5F51_RS13835	COG1722	exodeoxyribonuclease VII activity
D5F51_RS13840	COG0142	geranyltranstransferase activity
D5F51_RS13845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5F51_RS13850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5F51_RS13855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D5F51_RS13860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5F51_RS13865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5F51_RS13870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5F51_RS13870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5F51_RS13875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5F51_RS13885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5F51_RS13890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5F51_RS13895	COG1862	Preprotein translocase
D5F51_RS13900	COG0343	queuine tRNA-ribosyltransferase activity
D5F51_RS13910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5F51_RS13915	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D5F51_RS13920	COG0450	alkyl hydroperoxide reductase
D5F51_RS13935	COG0366	Alpha amylase catalytic
D5F51_RS13955	COG5002	protein histidine kinase activity
D5F51_RS13960	COG0745	RESPONSE REGULATOR receiver
D5F51_RS13965	COG0420	3'-5' exonuclease activity
D5F51_RS13970	COG0419	ATPase involved in DNA repair
D5F51_RS13975	COG1940	carbohydrate kinase activity
D5F51_RS13980	COG2974	May be involved in recombination
D5F51_RS13985	COG3123	guanosine phosphorylase activity
D5F51_RS13990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5F51_RS14000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5F51_RS14015	COG2226	methyltransferase
D5F51_RS14050	COG2188	Transcriptional regulator
D5F51_RS14055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_RS14060	COG2313	pseudouridylate synthase activity
D5F51_RS14065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_RS14070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5F51_RS14075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5F51_RS14085	COG1073	alpha beta
D5F51_RS14090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D5F51_RS14095	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5F51_RS14100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5F51_RS14115	COG2964	Protein conserved in bacteria
D5F51_RS14120	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5F51_RS14130	COG0584	glycerophosphoryl diester phosphodiesterase
D5F51_RS14145	COG2991	Protein conserved in bacteria
D5F51_RS14150	COG1477	protein flavinylation
D5F51_RS14155	COG2871	sodium ion transport
D5F51_RS14160	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_RS14165	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_RS14170	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_RS14175	COG1805	sodium ion transport
D5F51_RS14180	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D5F51_RS14185	COG3034	peptidoglycan biosynthetic process
D5F51_RS14190	COG0121	glutamine amidotransferase
D5F51_RS14200	COG1960	acyl-CoA dehydrogenase activity
D5F51_RS14205	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
D5F51_RS14220	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D5F51_RS14225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5F51_RS14230	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D5F51_RS14235	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D5F51_RS14240	COG0235	Class ii aldolase
D5F51_RS14245	COG2755	lipolytic protein G-D-S-L family
D5F51_RS14245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5F51_RS14250	COG3328	transposase activity
D5F51_RS14300	COG0582	viral genome integration into host DNA
D5F51_RS14305	COG0436	Aminotransferase
D5F51_RS14320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D5F51_RS14330	COG0765	amino acid transport
D5F51_RS14335	COG0765	amino acid transport
D5F51_RS14375	COG2814	Major facilitator Superfamily
D5F51_RS14380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D5F51_RS14390	COG1846	Transcriptional regulator
D5F51_RS14395	COG1538	Outer membrane efflux protein
D5F51_RS14400	COG1566	PFAM secretion protein HlyD family protein
D5F51_RS14405	COG2814	Major facilitator Superfamily
D5F51_RS14410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5F51_RS14415	COG3118	belongs to the thioredoxin family
D5F51_RS14420	COG3148	PFAM DTW domain containing protein
D5F51_RS14425	COG1042	CoA-binding domain protein
D5F51_RS14425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5F51_RS14425	COG0045	succinate-CoA ligase (ADP-forming) activity
D5F51_RS14430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5F51_RS14435	COG5544	Lipoprotein
D5F51_RS14470	COG0542	response to heat
D5F51_RS14480	COG0564	pseudouridine synthase activity
D5F51_RS14490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5F51_RS14495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5F51_RS14500	COG1605	Chorismate mutase
D5F51_RS14500	COG0077	Prephenate dehydratase
D5F51_RS14505	COG0287	Prephenate dehydrogenase
D5F51_RS14505	COG1605	Chorismate mutase
D5F51_RS14510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D5F51_RS14515	COG3279	Response regulator of the LytR AlgR family
D5F51_RS14520	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D5F51_RS14525	COG3137	Salt-induced outer membrane protein
D5F51_RS14530	COG0335	large ribosomal subunit rRNA binding
D5F51_RS14535	COG0336	Belongs to the RNA methyltransferase TrmD family
D5F51_RS14540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5F51_RS14550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5F51_RS14555	COG4137	Cytochrome C assembly protein
D5F51_RS14560	COG4536	flavin adenine dinucleotide binding
D5F51_RS14565	COG1854	S-ribosylhomocysteine lyase activity
D5F51_RS14570	COG2918	glutathione biosynthetic process
D5F51_RS14575	COG1238	metal cluster binding
D5F51_RS14580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_RS14605	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5F51_RS14610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5F51_RS14615	COG2137	regulation of response to DNA damage stimulus
D5F51_RS14620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5F51_RS14645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5F51_RS14650	COG3958	Transketolase
D5F51_RS14655	COG3959	Transketolase, thiamine diphosphate binding domain
D5F51_RS14660	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS14665	COG1129	ABC transporter
D5F51_RS14675	COG1879	ABC-type sugar transport system periplasmic component
D5F51_RS14680	COG3381	protein complex oligomerization
D5F51_RS14685	COG3302	dmso reductase anchor subunit
D5F51_RS14690	COG0437	4 iron, 4 sulfur cluster binding
D5F51_RS14695	COG0243	molybdopterin cofactor binding
D5F51_RS14700	COG0235	Class ii aldolase
D5F51_RS14705	COG1349	DNA-binding transcription factor activity
D5F51_RS14715	COG1129	ABC transporter
D5F51_RS14720	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS14730	COG3623	hexulose-6-phosphate isomerase
D5F51_RS14735	COG1070	Carbohydrate kinase
D5F51_RS14740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5F51_RS14740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5F51_RS14760	COG1137	ATPase activity
D5F51_RS14765	COG0410	ABC transporter
D5F51_RS14825	COG0640	Transcriptional regulator
D5F51_RS14830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5F51_RS14835	COG3158	transport of potassium into the cell
D5F51_RS14855	COG1126	abc transporter atp-binding protein
D5F51_RS14865	COG0765	amino acid transport
D5F51_RS14870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS14895	COG3048	D-serine ammonia-lyase activity
D5F51_RS14900	COG2610	gluconate transmembrane transporter activity
D5F51_RS14905	COG0583	DNA-binding transcription factor activity
D5F51_RS14910	COG4608	Belongs to the ABC transporter superfamily
D5F51_RS14915	COG0444	Belongs to the ABC transporter superfamily
D5F51_RS14920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_RS14925	COG0601	transmembrane transport
D5F51_RS14930	COG0747	negative chemotaxis
D5F51_RS14935	COG4948	Mandelate Racemase Muconate Lactonizing
D5F51_RS14940	COG1858	cytochrome C peroxidase
D5F51_RS14945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5F51_RS14950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS14975	COG1538	Outer membrane efflux protein
D5F51_RS14980	COG1136	(ABC) transporter
D5F51_RS14980	COG0577	efflux transmembrane transporter activity
D5F51_RS14985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS15000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5F51_RS15015	COG3539	Fimbrial protein
D5F51_RS15020	COG3539	Fimbrial protein
D5F51_RS15030	COG3121	Chaperone
D5F51_RS15035	COG3188	usher protein
D5F51_RS15085	COG2831	hemolysin activation secretion protein
D5F51_RS15115	COG3210	domain, Protein
D5F51_RS15155	COG3188	usher protein
D5F51_RS15160	COG3121	Chaperone
D5F51_RS15165	COG3539	Fimbrial protein
D5F51_RS15170	COG2824	Alkylphosphonate utilization operon protein PhnA
D5F51_RS15180	COG1695	Transcriptional regulator
D5F51_RS15190	COG2723	6-phospho-beta-galactosidase activity
D5F51_RS15200	COG1609	Transcriptional regulator
D5F51_RS15205	COG2353	YceI-like domain
D5F51_RS15210	COG3038	cytochrome b561
D5F51_RS15215	COG1902	pentaerythritol trinitrate reductase activity
D5F51_RS15230	COG1127	ABC transporter
D5F51_RS15235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5F51_RS15255	COG0531	amino acid
D5F51_RS15260	COG2951	lytic endotransglycosylase activity
D5F51_RS15280	COG1280	lysine exporter protein (LysE YggA)
D5F51_RS15295	COG2723	6-phospho-beta-galactosidase activity
D5F51_RS15310	COG0243	molybdopterin cofactor binding
D5F51_RS15315	COG0437	4 iron, 4 sulfur cluster binding
D5F51_RS15320	COG3302	dmso reductase anchor subunit
D5F51_RS15325	COG3381	protein complex oligomerization
D5F51_RS15335	COG1598	PFAM Uncharacterised protein family UPF0150
D5F51_RS15345	COG3038	cytochrome b561
D5F51_RS15350	COG0436	Aminotransferase
D5F51_RS15365	COG3275	phosphorelay sensor kinase activity
D5F51_RS15370	COG3279	Response regulator of the LytR AlgR family
D5F51_RS15375	COG2223	nitrite transmembrane transporter activity
D5F51_RS15380	COG0837	glucose binding
D5F51_RS15395	COG3961	Belongs to the TPP enzyme family
D5F51_RS15400	COG0667	Aldo Keto reductase
D5F51_RS15410	COG1914	H( )-stimulated, divalent metal cation uptake system
D5F51_RS15415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5F51_RS15440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5F51_RS15465	COG3530	Putative quorum-sensing-regulated virulence factor
D5F51_RS15470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5F51_RS15490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS15495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5F51_RS15505	COG2205	protein histidine kinase activity
D5F51_RS15510	COG0745	RESPONSE REGULATOR receiver
D5F51_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS15535	COG4208	sulfate ABC transporter
D5F51_RS15540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D5F51_RS15555	COG1737	Transcriptional regulator
D5F51_RS15560	COG2731	YhcH YjgK YiaL family protein
D5F51_RS15575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5F51_RS15580	COG2837	iron assimilation
D5F51_RS15590	COG3111	PFAM Bacterial OB fold (BOF) protein
D5F51_RS15600	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS15605	COG2897	thiosulfate sulfurtransferase activity
D5F51_RS15625	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5F51_RS15630	COG1129	ABC transporter
D5F51_RS15640	COG0456	acetyltransferase
D5F51_RS15645	COG0408	coproporphyrinogen oxidase activity
D5F51_RS15660	COG0494	nUDIX hydrolase
D5F51_RS15665	COG3005	denitrification pathway
D5F51_RS15670	COG3043	anaerobic respiration
D5F51_RS15675	COG0243	molybdopterin cofactor binding
D5F51_RS15680	COG3062	negative regulation of establishment of protein localization
D5F51_RS15690	COG2197	response regulator
D5F51_RS15700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_RS15710	COG1393	Belongs to the ArsC family
D5F51_RS15715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5F51_RS15720	COG1876	peptidase activity
D5F51_RS15730	COG0400	carboxylic ester hydrolase activity
D5F51_RS15735	COG1444	tRNA N-acetyltransferase activity
D5F51_RS15740	COG2707	UPF0756 membrane protein
D5F51_RS15745	COG2321	neutral zinc metallopeptidase
D5F51_RS15750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5F51_RS15755	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D5F51_RS15760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5F51_RS15765	COG2716	regulation of RNA biosynthetic process
D5F51_RS15770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5F51_RS15775	COG0628	permease
D5F51_RS15780	COG4783	chaperone-mediated protein folding
D5F51_RS15785	COG1393	Belongs to the ArsC family
D5F51_RS15790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5F51_RS15795	COG2233	PERMEase
D5F51_RS15800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5F51_RS15805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5F51_RS15810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5F51_RS15815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5F51_RS15825	COG0581	inorganic phosphate transmembrane transporter activity
D5F51_RS15835	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D5F51_RS15840	COG0248	Ppx GppA phosphatase
D5F51_RS15850	COG2239	Acts as a magnesium transporter
D5F51_RS15855	COG5002	protein histidine kinase activity
D5F51_RS15855	COG3447	MASE1 domain protein
D5F51_RS15855	COG5001	Diguanylate cyclase
D5F51_RS15860	COG0443	Heat shock 70 kDa protein
D5F51_RS15870	COG3121	Chaperone
D5F51_RS15885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS15895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_RS15900	COG0477	Major facilitator Superfamily
D5F51_RS15905	COG2205	protein histidine kinase activity
D5F51_RS15910	COG0745	RESPONSE REGULATOR receiver
D5F51_RS15915	COG3422	double-strand break repair
D5F51_RS15920	COG0826	peptidase U32
D5F51_RS15925	COG1597	lipid kinase activity
D5F51_RS15930	COG3730	PTS system glucitol sorbitol-specific
D5F51_RS15945	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS15950	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS15955	COG1349	DNA-binding transcription factor activity
D5F51_RS15980	COG0351	phosphomethylpyrimidine kinase
D5F51_RS15995	COG0519	Catalyzes the synthesis of GMP from XMP
D5F51_RS15995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5F51_RS16000	COG0517	IMP dehydrogenase activity
D5F51_RS16000	COG0516	GMP reductase activity
D5F51_RS16005	COG1570	exodeoxyribonuclease VII activity
D5F51_RS16010	COG1645	bacterial-type flagellum-dependent swarming motility
D5F51_RS16020	COG1160	GTP binding
D5F51_RS16025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5F51_RS16030	COG2976	Protein conserved in bacteria
D5F51_RS16035	COG0124	histidyl-tRNA synthetase
D5F51_RS16040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5F51_RS16045	COG1426	Protein conserved in bacteria
D5F51_RS16055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5F51_RS16070	COG4953	penicillin-binding protein 1C
D5F51_RS16075	COG2373	Large extracellular alpha-helical protein
D5F51_RS16095	COG2975	iron-sulfur cluster assembly
D5F51_RS16100	COG0633	Ferredoxin
D5F51_RS16105	COG0443	Heat shock 70 kDa protein
D5F51_RS16110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5F51_RS16125	COG0822	iron-sulfur transferase activity
D5F51_RS16135	COG1959	2 iron, 2 sulfur cluster binding
D5F51_RS16140	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D5F51_RS16150	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D5F51_RS16155	COG3683	transport system, periplasmic component
D5F51_RS16160	COG3711	transcriptional antiterminator
D5F51_RS16165	COG2814	Major facilitator Superfamily
D5F51_RS16170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5F51_RS16175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_RS16175	COG1017	nitric oxide dioxygenase activity
D5F51_RS16180	COG2188	Transcriptional regulator
D5F51_RS16190	COG3457	Alanine racemase
D5F51_RS16195	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D5F51_RS16210	COG0347	Belongs to the P(II) protein family
D5F51_RS16215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D5F51_RS16215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5F51_RS16220	COG2204	response regulator
D5F51_RS16225	COG3170	Tfp pilus assembly protein FimV
D5F51_RS16230	COG2205	protein histidine kinase activity
D5F51_RS16245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5F51_RS16260	COG0560	Phosphoserine phosphatase
D5F51_RS16270	COG1737	Transcriptional regulator
D5F51_RS16275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5F51_RS16280	COG2610	gluconate transmembrane transporter activity
D5F51_RS16285	COG0736	holo-[acyl-carrier-protein] synthase activity
D5F51_RS16290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D5F51_RS16295	COG1381	Involved in DNA repair and RecF pathway recombination
D5F51_RS16300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5F51_RS16315	COG0481	GTPase activity
D5F51_RS16325	COG3086	response to oxidative stress
D5F51_RS16335	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D5F51_RS16345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5F51_RS16350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5F51_RS16355	COG0513	Belongs to the DEAD box helicase family
D5F51_RS16370	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D5F51_RS16375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D5F51_RS16380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5F51_RS16385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5F51_RS16390	COG0497	DNA recombination
D5F51_RS16395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5F51_RS16405	COG2867	negative regulation of translational initiation
D5F51_RS16420	COG0582	viral genome integration into host DNA
D5F51_RS16535	COG3188	usher protein
D5F51_RS16540	COG3121	Chaperone
D5F51_RS16600	COG2197	response regulator
D5F51_RS16610	COG3394	polysaccharide catabolic process
D5F51_RS16615	COG1917	Cupin 2, conserved barrel domain protein
D5F51_RS16615	COG2169	Transcriptional regulator
D5F51_RS16620	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5F51_RS16625	COG2723	6-phospho-beta-galactosidase activity
D5F51_RS16630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5F51_RS16635	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5F51_RS16640	COG2133	pyrroloquinoline quinone binding
D5F51_RS16645	COG0667	Aldo Keto reductase
D5F51_RS16660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5F51_RS16670	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D5F51_RS16675	COG4413	Urea transporter
D5F51_RS16680	COG0829	nickel cation binding
D5F51_RS16685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5F51_RS16695	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5F51_RS16700	COG0804	urea catabolic process
D5F51_RS16710	COG0831	urea catabolic process
D5F51_RS16730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_RS16740	COG0747	negative chemotaxis
D5F51_RS16800	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D5F51_RS16805	COG4575	ribosome binding
D5F51_RS16810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5F51_RS16815	COG1780	Probably involved in ribonucleotide reductase function
D5F51_RS16825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5F51_RS16835	COG4176	ABC-type proline glycine betaine transport system permease component
D5F51_RS16840	COG2113	Glycine betaine
D5F51_RS16860	COG2226	methyltransferase
D5F51_RS16865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5F51_RS16870	COG1388	LysM domain
D5F51_RS16870	COG0741	lytic transglycosylase activity
D5F51_RS16875	COG3021	interspecies interaction between organisms
D5F51_RS16880	COG2814	Major facilitator Superfamily
D5F51_RS16885	COG0583	DNA-binding transcription factor activity
D5F51_RS16890	COG0656	L-ascorbic acid biosynthetic process
D5F51_RS16930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D5F51_RS16940	COG2011	ABC-type metal ion transport system permease component
D5F51_RS16945	COG1464	Belongs to the NlpA lipoprotein family
D5F51_RS16955	COG1720	tRNA m6t6A37 methyltransferase activity
D5F51_RS16960	COG0442	prolyl-tRNA aminoacylation
D5F51_RS16965	COG3015	lipoprotein NlpE involved in copper resistance
D5F51_RS16975	COG4681	YaeQ
D5F51_RS16985	COG4568	rho-dependent transcription termination
D5F51_RS17000	COG0346	lactoylglutathione lyase activity
D5F51_RS17020	COG0825	malonyl-CoA metabolic process
D5F51_RS17025	COG0587	DNA-directed DNA polymerase activity
D5F51_RS17030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5F51_RS17040	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_RS17045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5F51_RS17050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5F51_RS17055	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D5F51_RS17065	COG0750	zinc metalloprotease
D5F51_RS17070	COG0575	Belongs to the CDS family
D5F51_RS17080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5F51_RS17090	COG0528	UMP kinase activity
D5F51_RS17095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5F51_RS17100	COG0052	Belongs to the universal ribosomal protein uS2 family
D5F51_RS17115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D5F51_RS17120	COG2171	N-acyltransferase activity
D5F51_RS17135	COG0564	pseudouridine synthase activity
D5F51_RS17140	COG3098	single-species biofilm formation
D5F51_RS17150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5F51_RS17150	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5F51_RS17155	COG1611	Belongs to the LOG family
D5F51_RS17160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5F51_RS17165	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D5F51_RS17170	COG2363	Small membrane protein
D5F51_RS17175	COG0583	DNA-binding transcription factor activity
D5F51_RS17185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5F51_RS17190	COG2166	iron-sulfur cluster assembly
D5F51_RS17195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5F51_RS17200	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D5F51_RS17220	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5F51_RS17225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5F51_RS17225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D5F51_RS17230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5F51_RS17235	COG1074	ATP-dependent DNA helicase activity
D5F51_RS17240	COG1025	Belongs to the peptidase M16 family
D5F51_RS17245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5F51_RS17250	COG4967	type IV pilus modification protein PilV
D5F51_RS17275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5F51_RS17285	COG1051	belongs to the nudix hydrolase family
D5F51_RS17295	COG3066	DNA modification
D5F51_RS17300	COG0861	Integral membrane protein TerC family
D5F51_RS17305	COG0667	Aldo Keto reductase
D5F51_RS17310	COG0477	Major facilitator Superfamily
D5F51_RS17315	COG0318	PFAM AMP-dependent synthetase and ligase
D5F51_RS17315	COG0204	Acyl-transferase
D5F51_RS17325	COG1609	Transcriptional regulator
D5F51_RS17335	COG0583	DNA-binding transcription factor activity
D5F51_RS17340	COG2814	Major facilitator Superfamily
D5F51_RS17345	COG0583	DNA-binding transcription factor activity
D5F51_RS17400	COG2165	general secretion pathway protein
D5F51_RS17410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_RS17435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5F51_RS17480	COG0582	viral genome integration into host DNA
D5F51_RS17490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D5F51_RS17500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5F51_RS17505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5F51_RS17510	COG4974	Belongs to the 'phage' integrase family
D5F51_RS17515	COG0716	FMN binding
D5F51_RS17520	COG4452	Inner membrane protein CreD
D5F51_RS17525	COG2205	protein histidine kinase activity
D5F51_RS17530	COG0745	RESPONSE REGULATOR receiver
D5F51_RS17545	COG0354	folic acid binding
D5F51_RS17550	COG1272	protein, Hemolysin III
D5F51_RS17560	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS17570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5F51_RS17570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5F51_RS17575	COG0509	glycine decarboxylation via glycine cleavage system
D5F51_RS17580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5F51_RS17585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5F51_RS17590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5F51_RS17595	COG0006	proline dipeptidase activity
D5F51_RS17600	COG3079	Belongs to the UPF0149 family
D5F51_RS17605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D5F51_RS17615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D5F51_RS17620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5F51_RS17625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5F51_RS17630	COG0583	DNA-binding transcription factor activity
D5F51_RS17640	COG1279	arginine transmembrane transporter activity
D5F51_RS17655	COG0191	fructose-bisphosphate aldolase activity
D5F51_RS17660	COG0126	phosphoglycerate kinase activity
D5F51_RS17665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5F51_RS17675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5F51_RS17680	COG0501	Belongs to the peptidase M48B family
D5F51_RS17690	COG1166	arginine decarboxylase activity
D5F51_RS17710	COG0640	Transcriptional regulator
D5F51_RS17715	COG3091	SprT-like family
D5F51_RS17720	COG2356	endonuclease I
D5F51_RS17725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5F51_RS17730	COG0189	ligase activity
D5F51_RS17735	COG1678	Uncharacterized ACR, COG1678
D5F51_RS17740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5F51_RS17745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5F51_RS17755	COG2805	Type II/IV secretion system protein
D5F51_RS17760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5F51_RS17765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5F51_RS17770	COG0762	integral membrane protein
D5F51_RS17775	COG1872	DUF167
D5F51_RS17780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5F51_RS17785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5F51_RS17800	COG3171	Protein conserved in bacteria
D5F51_RS17810	COG2814	Major facilitator Superfamily
D5F51_RS17820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5F51_RS17825	COG1194	a g-specific adenine glycosylase
D5F51_RS17830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D5F51_RS17835	COG0741	lytic transglycosylase activity
D5F51_RS17845	COG1982	Orn Lys Arg decarboxylase major
D5F51_RS17855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5F51_RS17880	COG1074	ATP-dependent DNA helicase activity
D5F51_RS17885	COG1196	nuclear chromosome segregation
D5F51_RS18050	COG2885	chlorophyll binding
D5F51_RS18230	COG0741	lytic transglycosylase activity
D5F51_RS18245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_RS18285	COG0629	single-stranded DNA binding
D5F51_RS18325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5F51_RS18365	COG0583	DNA-binding transcription factor activity
D5F51_RS18470	COG2885	chlorophyll binding
D5F51_RS18495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5F51_RS18665	COG2205	protein histidine kinase activity
D5F51_RS18685	COG3031	protein transport across the cell outer membrane
D5F51_RS18695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5F51_RS18705	COG2165	general secretion pathway protein
D5F51_RS18740	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D5F51_RS18750	COG3397	chitin binding
D5F51_RS18785	COG1289	transmembrane transporter activity
D5F51_RS18810	COG0024	Methionine aminopeptidase
D5F51_RS18815	COG4604	ABC transporter, ATP-binding protein
D5F51_RS18820	COG4605	iron ion homeostasis
D5F51_RS18830	COG4607	ABC-type enterochelin transport system periplasmic component
D5F51_RS18835	COG1017	nitric oxide dioxygenase activity
D5F51_RS18835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5F51_RS18845	COG0477	Major facilitator Superfamily
D5F51_RS18850	COG1609	Transcriptional regulator
D5F51_RS18860	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5F51_RS18875	COG0477	Major facilitator Superfamily
D5F51_RS18895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5F51_RS18900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5F51_RS18905	COG0471	metal ion transport
D5F51_RS18935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D5F51_RS18940	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D5F51_RS18945	COG0309	Hydrogenase expression formation protein (HypE)
D5F51_RS18950	COG0409	Hydrogenase expression formation protein
D5F51_RS18955	COG0298	carbon dioxide binding
D5F51_RS18960	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5F51_RS18970	COG1773	rubredoxin
D5F51_RS18975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5F51_RS18980	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D5F51_RS18985	COG5557	Pfam Polysulphide reductase, NrfD
D5F51_RS18990	COG0437	4 iron, 4 sulfur cluster binding
D5F51_RS18995	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D5F51_RS19000	COG3133	Outer membrane lipoprotein
D5F51_RS19035	COG0840	transmembrane signaling receptor activity
D5F51_RS19040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5F51_RS19045	COG2271	Major facilitator Superfamily
D5F51_RS19050	COG1028	Short-chain dehydrogenase reductase Sdr
D5F51_RS19055	COG3433	isochorismatase activity
D5F51_RS19055	COG1535	isochorismatase
D5F51_RS19060	COG1021	2,3-dihydroxybenzoate-AMP ligase
D5F51_RS19065	COG1169	isochorismate synthase
D5F51_RS19070	COG4592	Periplasmic binding protein
D5F51_RS19080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_RS19085	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5F51_RS19090	COG1120	ATPase activity
D5F51_RS19095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5F51_RS19110	COG4774	siderophore transport
D5F51_RS19120	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS19130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5F51_RS19135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5F51_RS19160	COG4964	Belongs to the GSP D family
D5F51_RS19210	COG0848	biopolymer transport protein
D5F51_RS19225	COG0586	Pfam SNARE associated Golgi protein
D5F51_RS19230	COG2207	Transcriptional regulator
D5F51_RS19235	COG1979	alcohol dehydrogenase
D5F51_RS19240	COG0656	L-ascorbic acid biosynthetic process
D5F51_RS19250	COG2132	Multicopper oxidase
D5F51_RS19265	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5F51_RS19270	COG0583	DNA-binding transcription factor activity
D5F51_RS19280	COG3150	esterase
D5F51_RS19285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D5F51_RS19290	COG3151	Protein conserved in bacteria
D5F51_RS19295	COG0494	nUDIX hydrolase
D5F51_RS19300	COG1538	Outer membrane efflux protein
D5F51_RS19310	COG0754	glutathionylspermidine amidase activity
D5F51_RS19315	COG3384	dioxygenase
D5F51_RS19320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5F51_RS19330	COG0531	amino acid
D5F51_RS19335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5F51_RS19335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5F51_RS19340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5F51_RS19345	COG3025	triphosphatase activity
D5F51_RS19350	COG4991	sh3 domain protein
D5F51_RS19355	COG0617	tRNA 3'-terminal CCA addition
D5F51_RS19360	COG1968	undecaprenyl-diphosphatase activity
D5F51_RS19365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D5F51_RS19370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5F51_RS19375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5F51_RS19380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5F51_RS19385	COG0358	DNA primase activity
D5F51_RS19400	COG3876	Protein conserved in bacteria
D5F51_RS19410	COG1472	Belongs to the glycosyl hydrolase 3 family
D5F51_RS19420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5F51_RS19425	COG1263	PTS System
D5F51_RS19425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS19435	COG0531	amino acid
D5F51_RS19440	COG0076	glutamate decarboxylase activity
D5F51_RS19450	COG2814	Major facilitator Superfamily
D5F51_RS19455	COG3247	response to pH
D5F51_RS19470	COG1902	pentaerythritol trinitrate reductase activity
D5F51_RS19470	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5F51_RS19475	COG2813	Specifically methylates the guanine in position
D5F51_RS19485	COG1451	nucleotide metabolic process
D5F51_RS19490	COG0673	inositol 2-dehydrogenase activity
D5F51_RS19495	COG0861	Integral membrane protein TerC family
D5F51_RS19500	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D5F51_RS19510	COG2721	sulfolactate sulfo-lyase activity
D5F51_RS19515	COG0246	Mannitol dehydrogenase
D5F51_RS19520	COG1904	glucuronate isomerase
D5F51_RS19525	COG2271	Major facilitator Superfamily
D5F51_RS19540	COG0586	Pfam SNARE associated Golgi protein
D5F51_RS19555	COG4575	ribosome binding
D5F51_RS19560	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
D5F51_RS19570	COG2259	Doxx family
D5F51_RS19575	COG0435	Glutathione S-transferase
D5F51_RS19580	COG0583	DNA-binding transcription factor activity
D5F51_RS19585	COG1741	Belongs to the pirin family
D5F51_RS19590	COG1064	alcohol dehydrogenase
D5F51_RS19595	COG4221	oxidoreductase activity
D5F51_RS19605	COG0667	Aldo Keto reductase
D5F51_RS19640	COG3469	chitinase activity
D5F51_RS19645	COG3397	chitin binding
D5F51_RS19665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5F51_RS19675	COG0792	nuclease activity
D5F51_RS19680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5F51_RS19685	COG2823	Periplasmic or secreted lipoprotein
D5F51_RS19690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5F51_RS19695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D5F51_RS19705	COG5002	protein histidine kinase activity
D5F51_RS19705	COG2198	Histidine kinase
D5F51_RS19705	COG0784	Response regulator, receiver
D5F51_RS19710	COG1242	4 iron, 4 sulfur cluster binding
D5F51_RS19715	COG0069	glutamate synthase activity
D5F51_RS19715	COG0067	glutamate synthase
D5F51_RS19715	COG0070	glutamate synthase
D5F51_RS19720	COG0493	'glutamate synthase
D5F51_RS19730	COG2969	positive regulation of protein catabolic process
D5F51_RS19735	COG0625	glutathione transferase activity
D5F51_RS19740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5F51_RS19745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5F51_RS19750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D5F51_RS19755	COG3105	Protein conserved in bacteria
D5F51_RS19760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5F51_RS19765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5F51_RS19770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5F51_RS19775	COG5007	Belongs to the BolA IbaG family
D5F51_RS19780	COG3113	response to antibiotic
D5F51_RS19785	COG2854	intermembrane phospholipid transfer
D5F51_RS19790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5F51_RS19795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5F51_RS19800	COG1127	ABC transporter
D5F51_RS19805	COG0530	calcium, potassium:sodium antiporter activity
D5F51_RS19810	COG0517	IMP dehydrogenase activity
D5F51_RS19810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D5F51_RS19815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5F51_RS19820	COG3117	lipopolysaccharide transmembrane transporter activity
D5F51_RS19825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D5F51_RS19830	COG1137	ATPase activity
D5F51_RS19835	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5F51_RS19845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS19850	COG1660	Displays ATPase and GTPase activities
D5F51_RS19855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS19860	COG0540	Belongs to the ATCase OTCase family
D5F51_RS19865	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D5F51_RS19875	COG2308	Evidence 4 Homologs of previously reported genes of
D5F51_RS19895	COG0366	Alpha amylase catalytic
D5F51_RS19900	COG1263	PTS System
D5F51_RS19900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5F51_RS19905	COG1609	Transcriptional regulator
D5F51_RS19910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5F51_RS19915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS19915	COG3711	transcriptional antiterminator
D5F51_RS19920	COG2706	6-phosphogluconolactonase activity
D5F51_RS19935	COG3964	amidohydrolase
D5F51_RS19965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5F51_RS19970	COG3783	Cytochrome b(562)
D5F51_RS19975	COG0312	modulator of DNA gyrase
D5F51_RS19980	COG3028	Belongs to the UPF0307 family
D5F51_RS19985	COG2732	(Barnase) inhibitor
D5F51_RS20000	COG1289	transmembrane transporter activity
D5F51_RS20005	COG1566	PFAM secretion protein HlyD family protein
D5F51_RS20015	COG0583	DNA-binding transcription factor activity
D5F51_RS20020	COG0312	modulator of DNA gyrase
D5F51_RS20025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5F51_RS20030	COG3164	Protein of unknown function
D5F51_RS20035	COG1530	ribonuclease E activity
D5F51_RS20040	COG0424	maF-like protein
D5F51_RS20045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D5F51_RS20050	COG1792	Involved in formation and maintenance of cell shape
D5F51_RS20055	COG1077	Cell shape determining protein MreB Mrl
D5F51_RS20060	COG2199	diguanylate cyclase activity
D5F51_RS20060	COG2200	EAL domain
D5F51_RS20065	COG0604	alcohol dehydrogenase
D5F51_RS20075	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5F51_RS20080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5F51_RS20085	COG0511	ligase activity, forming carbon-carbon bonds
D5F51_RS20090	COG0439	Biotin carboxylase
D5F51_RS20095	COG3924	membrane
D5F51_RS20100	COG4145	pantothenate transmembrane transporter activity
D5F51_RS20105	COG2264	protein methyltransferase activity
D5F51_RS20110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5F51_RS20115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D5F51_RS20120	COG3706	GGDEF domain
D5F51_RS20125	COG3133	Outer membrane lipoprotein
D5F51_RS20130	COG1278	Cold shock
D5F51_RS20135	COG1278	Cold shock
D5F51_RS20140	COG0471	metal ion transport
D5F51_RS20145	COG1560	Kdo2-lipid A biosynthetic process
D5F51_RS20155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS20160	COG4597	amino acid ABC transporter
D5F51_RS20165	COG0765	amino acid transport
D5F51_RS20170	COG1126	abc transporter atp-binding protein
D5F51_RS20180	COG1380	Effector of murein hydrolase LrgA
D5F51_RS20185	COG0583	DNA-binding transcription factor activity
D5F51_RS20190	COG0025	NhaP-type Na H and K H
D5F51_RS20195	COG2252	PERMEase
D5F51_RS20210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5F51_RS20215	COG2315	Protein conserved in bacteria
D5F51_RS20220	COG1448	Aminotransferase
D5F51_RS20235	COG0604	alcohol dehydrogenase
D5F51_RS20250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5F51_RS20260	COG0735	belongs to the Fur family
D5F51_RS20265	COG3237	CsbD-like
D5F51_RS20270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5F51_RS20275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5F51_RS20280	COG2937	Belongs to the GPAT DAPAT family
D5F51_RS20285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5F51_RS20290	COG3161	chorismate lyase activity
D5F51_RS20305	COG4580	involved in the transport of maltose and maltodextrins
D5F51_RS20320	COG2182	Extracellular solute-binding protein
D5F51_RS20325	COG1175	transmembrane transport
D5F51_RS20330	COG3833	ABC-type maltose transport systems, permease component
D5F51_RS20345	COG0527	aspartate kinase activity
D5F51_RS20365	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
D5F51_RS20370	COG2224	Isocitrate lyase
D5F51_RS20375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5F51_RS20380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D5F51_RS20425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5F51_RS20430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5F51_RS20435	COG0009	L-threonylcarbamoyladenylate synthase
D5F51_RS20440	COG0551	DNA topoisomerase type I activity
D5F51_RS20450	COG0758	DNA mediated transformation
D5F51_RS20455	COG0242	peptide deformylase activity
D5F51_RS20460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5F51_RS20465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5F51_RS20465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5F51_RS20475	COG1970	mechanosensitive ion channel activity
D5F51_RS20480	COG3036	rescue of stalled ribosome
D5F51_RS20485	COG0789	Transcriptional regulator
D5F51_RS20495	COG0203	ribosomal protein L17
D5F51_RS20500	COG0202	RNA polymerase activity
D5F51_RS20505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5F51_RS20510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5F51_RS20515	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5F51_RS20520	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5F51_RS20525	COG0201	protein transport
D5F51_RS20530	COG0200	Binds to the 23S rRNA
D5F51_RS20535	COG1841	ribosomal large subunit assembly
D5F51_RS20540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5F51_RS20550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5F51_RS20560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5F51_RS20565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5F51_RS20575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5F51_RS20580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5F51_RS20585	COG0255	Belongs to the universal ribosomal protein uL29 family
D5F51_RS20590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5F51_RS20595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5F51_RS20605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5F51_RS20615	COG0089	rRNA binding
D5F51_RS20620	COG0088	Forms part of the polypeptide exit tunnel
D5F51_RS20625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5F51_RS20630	COG0051	transcription antitermination factor activity, RNA binding
D5F51_RS20660	COG0049	tRNA binding
D5F51_RS20665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D5F51_RS20670	COG2168	tRNA wobble position uridine thiolation
D5F51_RS20675	COG2923	Belongs to the DsrF TusC family
D5F51_RS20685	COG2964	Protein conserved in bacteria
D5F51_RS20690	COG0545	Peptidyl-prolyl cis-trans isomerase
D5F51_RS20695	COG2900	Belongs to the SlyX family
D5F51_RS20700	COG1047	Peptidyl-prolyl cis-trans
D5F51_RS20705	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D5F51_RS20715	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5F51_RS20720	COG0488	(ABC) transporter
D5F51_RS20730	COG2175	clavaminate synthase activity
D5F51_RS20735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5F51_RS20745	COG4521	taurine ABC transporter
D5F51_RS20760	COG0429	hydrolase of the alpha beta-hydrolase fold
D5F51_RS20765	COG3089	Belongs to the UPF0270 family
D5F51_RS20770	COG3954	Phosphoribulokinase
D5F51_RS20775	COG1765	OsmC-like protein
D5F51_RS20785	COG1289	transmembrane transporter activity
D5F51_RS20800	COG0433	COG0433 Predicted ATPase
D5F51_RS20805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5F51_RS20810	COG1486	melibiose metabolic process
D5F51_RS20830	COG0738	Major facilitator superfamily
D5F51_RS20835	COG0402	S-adenosylhomocysteine deaminase activity
D5F51_RS20840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5F51_RS20855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_RS20855	COG1648	precorrin-2 dehydrogenase activity
D5F51_RS20860	COG0180	Tryptophanyl-tRNA synthetase
D5F51_RS20870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5F51_RS20890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5F51_RS20895	COG4796	Type ii and iii secretion system protein
D5F51_RS20920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5F51_RS20925	COG0494	nUDIX hydrolase
D5F51_RS20935	COG1011	Hydrolase
D5F51_RS20940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5F51_RS20950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D5F51_RS20965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5F51_RS20970	COG2183	response to ionizing radiation
D5F51_RS20975	COG1918	ferrous iron import across plasma membrane
D5F51_RS20995	COG0596	Alpha beta hydrolase
D5F51_RS21000	COG1040	competence protein
D5F51_RS21005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5F51_RS21005	COG0316	Belongs to the HesB IscA family
D5F51_RS21010	COG1640	4-alpha-glucanotransferase
D5F51_RS21015	COG0058	SHG alpha-glucan phosphorylase activity
D5F51_RS21020	COG2909	trisaccharide binding
D5F51_RS21035	COG0705	Rhomboid family
D5F51_RS21040	COG1349	DNA-binding transcription factor activity
D5F51_RS21045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5F51_RS21050	COG0058	SHG alpha-glucan phosphorylase activity
D5F51_RS21055	COG0297	glycogen (starch) synthase activity
D5F51_RS21065	COG1523	belongs to the glycosyl hydrolase 13 family
D5F51_RS21070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D5F51_RS21075	COG3275	phosphorelay sensor kinase activity
D5F51_RS21080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5F51_RS21085	COG2095	MarC family integral membrane protein
D5F51_RS21090	COG3265	gluconokinase activity
D5F51_RS21095	COG2610	gluconate transmembrane transporter activity
D5F51_RS21100	COG1609	Transcriptional regulator
D5F51_RS21105	COG1741	Belongs to the pirin family
D5F51_RS21115	COG1247	-acetyltransferase
D5F51_RS21120	COG1082	Xylose isomerase domain protein TIM barrel
D5F51_RS21125	COG0673	inositol 2-dehydrogenase activity
D5F51_RS21135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_RS21145	COG3718	enzyme involved in inositol metabolism
D5F51_RS21155	COG2814	Major facilitator Superfamily
D5F51_RS21165	COG0561	phosphatase activity
D5F51_RS21180	COG0583	DNA-binding transcription factor activity
D5F51_RS21185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5F51_RS21185	COG1648	precorrin-2 dehydrogenase activity
D5F51_RS21195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D5F51_RS21205	COG4865	methylaspartate mutase activity
D5F51_RS21210	COG3799	methylaspartate ammonia-lyase activity
D5F51_RS21225	COG1301	dicarboxylic acid transport
D5F51_RS21230	COG3344	reverse transcriptase
D5F51_RS21290	COG2081	HI0933 family
D5F51_RS21295	COG0306	phosphate transporter
D5F51_RS21305	COG0589	response to stress
D5F51_RS21320	COG0742	ribosomal rna small subunit methyltransferase
D5F51_RS21335	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D5F51_RS21340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5F51_RS21350	COG1295	ribonuclease BN
D5F51_RS21355	COG0477	Major facilitator Superfamily
D5F51_RS21360	COG2134	cdp-diacylglycerol pyrophosphatase
D5F51_RS21365	COG2982	Protein involved in outer membrane biogenesis
D5F51_RS21370	COG2200	EAL domain
D5F51_RS21375	COG1942	4-Oxalocrotonate Tautomerase
D5F51_RS21380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5F51_RS21385	COG0612	Peptidase, M16
D5F51_RS21390	COG1301	dicarboxylic acid transport
D5F51_RS21405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5F51_RS21410	COG2199	diguanylate cyclase activity
D5F51_RS21410	COG2200	EAL domain
D5F51_RS21420	COG3118	belongs to the thioredoxin family
D5F51_RS21420	COG0457	Tetratricopeptide repeat
D5F51_RS21425	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D5F51_RS21435	COG1215	transferase activity, transferring glycosyl groups
D5F51_RS21440	COG1192	Involved in chromosome partitioning
D5F51_RS21460	COG2194	sulfuric ester hydrolase activity
D5F51_RS21470	COG4608	Belongs to the ABC transporter superfamily
D5F51_RS21475	COG0444	Belongs to the ABC transporter superfamily
D5F51_RS21480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5F51_RS21485	COG0601	transmembrane transport
D5F51_RS21490	COG0747	negative chemotaxis
D5F51_RS21495	COG3210	domain, Protein
D5F51_RS21500	COG2831	hemolysin activation secretion protein
D5F51_RS21520	COG3851	Histidine kinase
D5F51_RS21525	COG2197	response regulator
D5F51_RS21530	COG2194	sulfuric ester hydrolase activity
D5F51_RS21535	COG1764	response to oxidative stress
D5F51_RS21550	COG2986	histidine ammonia-lyase
D5F51_RS21555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D5F51_RS21560	COG1609	Transcriptional regulator
D5F51_RS21645	COG0582	viral genome integration into host DNA
D5F51_RS21655	COG1609	Transcriptional regulator
D5F51_RS21655	COG2207	Transcriptional regulator
D5F51_RS21660	COG4214	carbohydrate transport
D5F51_RS21670	COG4213	ABC transporter substrate-binding protein
D5F51_RS21675	COG2115	Belongs to the xylose isomerase family
D5F51_RS21680	COG1070	Carbohydrate kinase
D5F51_RS21685	COG3121	Chaperone
D5F51_RS21690	COG1335	isochorismatase
D5F51_RS21700	COG3274	enterobacterial common antigen metabolic process
D5F51_RS21710	COG3276	selenocysteine insertion sequence binding
D5F51_RS21715	COG1921	L-seryl-tRNASec selenium transferase activity
D5F51_RS21720	COG3058	Necessary for formate dehydrogenase activity
D5F51_RS21725	COG2864	formate dehydrogenase
D5F51_RS21730	COG0437	4 iron, 4 sulfur cluster binding
D5F51_RS21735	COG0243	molybdopterin cofactor binding
D5F51_RS21735	COG3383	formate dehydrogenase (NAD+) activity
D5F51_RS21740	COG0243	molybdopterin cofactor binding
D5F51_RS21740	COG3383	formate dehydrogenase (NAD+) activity
D5F51_RS21745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5F51_RS21750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5F51_RS21755	COG0840	transmembrane signaling receptor activity
D5F51_RS21760	COG2258	MOSC domain
D5F51_RS21770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5F51_RS21780	COG3722	fumarate hydratase activity
D5F51_RS21785	COG0246	Mannitol dehydrogenase
D5F51_RS21790	COG2213	PTS system mannitol-specific
D5F51_RS21790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5F51_RS21800	COG0751	glycine-tRNA ligase activity
D5F51_RS21805	COG0752	glycyl-tRNA synthetase alpha subunit
D5F51_RS21810	COG2818	Glycosylase
D5F51_RS21815	COG0456	acetyltransferase
D5F51_RS21840	COG0366	Alpha amylase catalytic
D5F51_RS21845	COG3977	Valine--pyruvate aminotransferase
D5F51_RS21865	COG5645	(Lipo)protein
D5F51_RS21870	COG0823	Involved in the tonB-independent uptake of proteins
D5F51_RS21885	COG2423	ornithine cyclodeaminase activity
D5F51_RS21895	COG3188	usher protein
D5F51_RS21900	COG3121	Chaperone
D5F51_RS21910	COG3328	transposase activity
D5F51_RS21915	COG0561	phosphatase activity
D5F51_RS21920	COG0187	DNA topoisomerase II activity
D5F51_RS21930	COG0592	DNA-directed DNA polymerase activity
D5F51_RS21935	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5F51_RS21945	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5F51_RS21950	COG0594	ribonuclease P activity
D5F51_RS21955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5F51_RS21960	COG0706	membrane insertase activity
D5F51_RS21965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5F51_RS21970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5F51_RS21985	COG2011	ABC-type metal ion transport system permease component
D5F51_RS21990	COG0840	transmembrane signaling receptor activity
D5F51_RS21995	COG0431	NADPH-dependent FMN reductase
D5F51_RS22015	COG2252	PERMEase
D5F51_RS22020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5F51_RS22030	COG0765	amino acid transport
D5F51_RS22035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5F51_RS22050	COG0704	Plays a role in the regulation of phosphate uptake
D5F51_RS22060	COG0581	inorganic phosphate transmembrane transporter activity
D5F51_RS22065	COG0573	inorganic phosphate transmembrane transporter activity
D5F51_RS22070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5F51_RS22090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5F51_RS22095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5F51_RS22100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5F51_RS22105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5F51_RS22110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5F51_RS22115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5F51_RS22120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5F51_RS22130	COG0356	it plays a direct role in the translocation of protons across the membrane
D5F51_RS22135	COG3312	ion transport
D5F51_RS22140	COG0357	Ribosomal RNA small subunit methyltransferase G
D5F51_RS22145	COG0445	tRNA wobble uridine modification
D5F51_RS22155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5F51_RS22165	COG1470	cell adhesion involved in biofilm formation
D5F51_RS22165	COG1388	LysM domain
D5F51_RS22255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5F51_RS22260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5F51_RS22295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5F51_RS22335	COG3121	Chaperone
D5F51_RS22340	COG3188	usher protein
D5F51_RS22350	COG0789	Transcriptional regulator
D5F51_RS22385	COG1393	Belongs to the ArsC family