locus-tag	class	description
A6J67_RS00030	COG0848	biopolymer transport protein
A6J67_RS00040	COG0626	cystathionine gamma-synthase activity
A6J67_RS00045	COG0586	Pfam SNARE associated Golgi protein
A6J67_RS00050	COG2207	Transcriptional regulator
A6J67_RS00055	COG1979	alcohol dehydrogenase
A6J67_RS00060	COG0656	L-ascorbic acid biosynthetic process
A6J67_RS00080	COG2132	Multicopper oxidase
A6J67_RS00085	COG0204	Acyl-transferase
A6J67_RS00090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J67_RS00100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS00105	COG3715	PTS system
A6J67_RS00110	COG3716	PTS system mannose fructose sorbose family IID component
A6J67_RS00120	COG0583	DNA-binding transcription factor activity
A6J67_RS00125	COG0667	Aldo Keto reductase
A6J67_RS00130	COG1653	transport
A6J67_RS00145	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J67_RS00150	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A6J67_RS00165	COG3150	esterase
A6J67_RS00170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6J67_RS00175	COG3151	Protein conserved in bacteria
A6J67_RS00180	COG0494	nUDIX hydrolase
A6J67_RS00185	COG1538	Outer membrane efflux protein
A6J67_RS00190	COG5463	Belongs to the UPF0441 family
A6J67_RS00195	COG0754	glutathionylspermidine amidase activity
A6J67_RS00205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J67_RS00215	COG0531	amino acid
A6J67_RS00220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J67_RS00220	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6J67_RS00235	COG3025	triphosphatase activity
A6J67_RS00240	COG4991	sh3 domain protein
A6J67_RS00245	COG0617	tRNA 3'-terminal CCA addition
A6J67_RS00255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6J67_RS00260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J67_RS00265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J67_RS00270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J67_RS00275	COG0358	DNA primase activity
A6J67_RS00305	COG2003	Belongs to the UPF0758 family
A6J67_RS00325	COG2378	regulation of single-species biofilm formation
A6J67_RS00330	COG3596	GTP binding
A6J67_RS00370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J67_RS00380	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J67_RS00430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6J67_RS00480	COG3468	outer membrane autotransporter barrel domain protein
A6J67_RS00485	COG2831	hemolysin activation secretion protein
A6J67_RS00510	COG4983	Phage plasmid primase, P4 family domain protein
A6J67_RS00580	COG2814	Major facilitator Superfamily
A6J67_RS00585	COG3247	response to pH
A6J67_RS00595	COG2378	regulation of single-species biofilm formation
A6J67_RS00605	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J67_RS00605	COG1902	pentaerythritol trinitrate reductase activity
A6J67_RS00610	COG2813	Specifically methylates the guanine in position
A6J67_RS00615	COG3468	outer membrane autotransporter barrel domain protein
A6J67_RS00620	COG1451	nucleotide metabolic process
A6J67_RS00625	COG0673	inositol 2-dehydrogenase activity
A6J67_RS00630	COG0861	Integral membrane protein TerC family
A6J67_RS00635	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6J67_RS00645	COG2721	sulfolactate sulfo-lyase activity
A6J67_RS00650	COG0246	Mannitol dehydrogenase
A6J67_RS00660	COG2271	Major facilitator Superfamily
A6J67_RS00675	COG0586	Pfam SNARE associated Golgi protein
A6J67_RS00690	COG4575	ribosome binding
A6J67_RS00695	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A6J67_RS00705	COG2259	Doxx family
A6J67_RS00710	COG0435	Glutathione S-transferase
A6J67_RS00715	COG0583	DNA-binding transcription factor activity
A6J67_RS00720	COG1741	Belongs to the pirin family
A6J67_RS00725	COG1064	alcohol dehydrogenase
A6J67_RS00740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J67_RS00750	COG0792	nuclease activity
A6J67_RS00755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J67_RS00760	COG2823	Periplasmic or secreted lipoprotein
A6J67_RS00765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J67_RS00770	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6J67_RS00780	COG5002	protein histidine kinase activity
A6J67_RS00780	COG0784	Response regulator, receiver
A6J67_RS00780	COG2198	Histidine kinase
A6J67_RS00785	COG1242	4 iron, 4 sulfur cluster binding
A6J67_RS00790	COG0067	glutamate synthase
A6J67_RS00790	COG0069	glutamate synthase activity
A6J67_RS00790	COG0070	glutamate synthase
A6J67_RS00795	COG0493	'glutamate synthase
A6J67_RS00805	COG2969	positive regulation of protein catabolic process
A6J67_RS00810	COG0625	glutathione transferase activity
A6J67_RS00820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J67_RS00825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J67_RS00830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6J67_RS00835	COG3105	Protein conserved in bacteria
A6J67_RS00840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J67_RS00845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J67_RS00850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J67_RS00855	COG5007	Belongs to the BolA IbaG family
A6J67_RS00860	COG3113	response to antibiotic
A6J67_RS00865	COG2854	intermembrane phospholipid transfer
A6J67_RS00870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J67_RS00875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J67_RS00880	COG1127	ABC transporter
A6J67_RS00885	COG0530	calcium, potassium:sodium antiporter activity
A6J67_RS00890	COG0517	IMP dehydrogenase activity
A6J67_RS00890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6J67_RS00895	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6J67_RS00900	COG3117	lipopolysaccharide transmembrane transporter activity
A6J67_RS00905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6J67_RS00910	COG1137	ATPase activity
A6J67_RS00915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6J67_RS00930	COG1660	Displays ATPase and GTPase activities
A6J67_RS00935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS00940	COG2271	Major facilitator Superfamily
A6J67_RS00945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J67_RS00950	COG0540	Belongs to the ATCase OTCase family
A6J67_RS00955	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6J67_RS00970	COG0366	Alpha amylase catalytic
A6J67_RS00975	COG1263	PTS System
A6J67_RS00975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS00985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J67_RS00995	COG3093	addiction module antidote protein HigA
A6J67_RS01000	COG3711	transcriptional antiterminator
A6J67_RS01000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS01015	COG3964	amidohydrolase
A6J67_RS01045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J67_RS01050	COG3783	Cytochrome b(562)
A6J67_RS01055	COG0312	modulator of DNA gyrase
A6J67_RS01060	COG3028	Belongs to the UPF0307 family
A6J67_RS01065	COG2732	(Barnase) inhibitor
A6J67_RS01075	COG1012	belongs to the aldehyde dehydrogenase family
A6J67_RS01080	COG1289	transmembrane transporter activity
A6J67_RS01085	COG1566	PFAM secretion protein HlyD family protein
A6J67_RS01095	COG0583	DNA-binding transcription factor activity
A6J67_RS01100	COG0312	modulator of DNA gyrase
A6J67_RS01105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J67_RS01110	COG3164	Protein of unknown function
A6J67_RS01115	COG1530	ribonuclease E activity
A6J67_RS01120	COG0424	maF-like protein
A6J67_RS01125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6J67_RS01130	COG1792	Involved in formation and maintenance of cell shape
A6J67_RS01135	COG1077	Cell shape determining protein MreB Mrl
A6J67_RS01140	COG2199	diguanylate cyclase activity
A6J67_RS01140	COG2200	EAL domain
A6J67_RS01145	COG0604	alcohol dehydrogenase
A6J67_RS01155	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A6J67_RS01165	COG0511	ligase activity, forming carbon-carbon bonds
A6J67_RS01170	COG0439	Biotin carboxylase
A6J67_RS01175	COG3924	membrane
A6J67_RS01180	COG4145	pantothenate transmembrane transporter activity
A6J67_RS01185	COG2264	protein methyltransferase activity
A6J67_RS01190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J67_RS01195	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6J67_RS01200	COG3133	Outer membrane lipoprotein
A6J67_RS01205	COG1278	Cold shock
A6J67_RS01210	COG1278	Cold shock
A6J67_RS01215	COG0471	metal ion transport
A6J67_RS01225	COG1069	ribulokinase activity
A6J67_RS01235	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS01240	COG1129	ABC transporter
A6J67_RS01250	COG1560	Kdo2-lipid A biosynthetic process
A6J67_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS01265	COG4597	amino acid ABC transporter
A6J67_RS01270	COG0765	amino acid transport
A6J67_RS01275	COG1126	abc transporter atp-binding protein
A6J67_RS01285	COG1380	Effector of murein hydrolase LrgA
A6J67_RS01290	COG0583	DNA-binding transcription factor activity
A6J67_RS01295	COG0025	NhaP-type Na H and K H
A6J67_RS01300	COG2252	PERMEase
A6J67_RS01320	COG0629	single-stranded DNA binding
A6J67_RS01325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J67_RS01330	COG2315	Protein conserved in bacteria
A6J67_RS01335	COG1448	Aminotransferase
A6J67_RS01350	COG0604	alcohol dehydrogenase
A6J67_RS01360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J67_RS01365	COG0735	belongs to the Fur family
A6J67_RS01370	COG3237	CsbD-like
A6J67_RS01375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6J67_RS01380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J67_RS01385	COG2937	Belongs to the GPAT DAPAT family
A6J67_RS01395	COG3161	chorismate lyase activity
A6J67_RS01405	COG4580	involved in the transport of maltose and maltodextrins
A6J67_RS01425	COG1175	transmembrane transport
A6J67_RS01430	COG3833	ABC-type maltose transport systems, permease component
A6J67_RS01440	COG3223	Belongs to the PsiE family
A6J67_RS01450	COG0527	aspartate kinase activity
A6J67_RS01475	COG1414	Transcriptional regulator
A6J67_RS01480	COG3852	Histidine kinase
A6J67_RS01485	COG2204	response regulator
A6J67_RS01490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A6J67_RS01495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A6J67_RS01500	COG2031	fatty acid transporter
A6J67_RS01505	COG0183	Belongs to the thiolase family
A6J67_RS01510	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A6J67_RS01515	COG2224	Isocitrate lyase
A6J67_RS01520	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6J67_RS01525	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6J67_RS01565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J67_RS01570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J67_RS01575	COG0009	L-threonylcarbamoyladenylate synthase
A6J67_RS01580	COG0551	DNA topoisomerase type I activity
A6J67_RS01590	COG0758	DNA mediated transformation
A6J67_RS01595	COG0242	peptide deformylase activity
A6J67_RS01600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J67_RS01605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J67_RS01605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J67_RS01610	COG0569	domain protein
A6J67_RS01615	COG1970	mechanosensitive ion channel activity
A6J67_RS01620	COG3036	rescue of stalled ribosome
A6J67_RS01625	COG0789	Transcriptional regulator
A6J67_RS01635	COG0203	ribosomal protein L17
A6J67_RS01645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J67_RS01650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J67_RS01655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J67_RS01660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J67_RS01665	COG0201	protein transport
A6J67_RS01670	COG0200	Binds to the 23S rRNA
A6J67_RS01675	COG1841	ribosomal large subunit assembly
A6J67_RS01680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J67_RS01685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6J67_RS01690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J67_RS01695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J67_RS01700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J67_RS01710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J67_RS01715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J67_RS01720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J67_RS01725	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J67_RS01730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J67_RS01735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J67_RS01745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J67_RS01755	COG0089	rRNA binding
A6J67_RS01770	COG0051	transcription antitermination factor activity, RNA binding
A6J67_RS01785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J67_RS01800	COG0049	tRNA binding
A6J67_RS01805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6J67_RS01810	COG2168	tRNA wobble position uridine thiolation
A6J67_RS01815	COG2923	Belongs to the DsrF TusC family
A6J67_RS01820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6J67_RS01825	COG2964	Protein conserved in bacteria
A6J67_RS01830	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J67_RS01840	COG1047	Peptidyl-prolyl cis-trans
A6J67_RS01845	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A6J67_RS01855	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J67_RS01860	COG0488	(ABC) transporter
A6J67_RS01865	COG1216	Glycosyl transferase, family 2
A6J67_RS01875	COG2175	clavaminate synthase activity
A6J67_RS01880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J67_RS01890	COG4521	taurine ABC transporter
A6J67_RS01905	COG0429	hydrolase of the alpha beta-hydrolase fold
A6J67_RS01910	COG3089	Belongs to the UPF0270 family
A6J67_RS01915	COG3954	Phosphoribulokinase
A6J67_RS01920	COG1765	OsmC-like protein
A6J67_RS01930	COG1289	transmembrane transporter activity
A6J67_RS01950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J67_RS01960	COG1486	melibiose metabolic process
A6J67_RS01965	COG1609	Transcriptional regulator
A6J67_RS01980	COG0738	Major facilitator superfamily
A6J67_RS01985	COG0402	S-adenosylhomocysteine deaminase activity
A6J67_RS01990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6J67_RS02005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J67_RS02005	COG1648	precorrin-2 dehydrogenase activity
A6J67_RS02010	COG0180	Tryptophanyl-tRNA synthetase
A6J67_RS02020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J67_RS02040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J67_RS02070	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6J67_RS02075	COG0494	nUDIX hydrolase
A6J67_RS02085	COG1011	Hydrolase
A6J67_RS02090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J67_RS02120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J67_RS02125	COG2183	response to ionizing radiation
A6J67_RS02130	COG1918	ferrous iron import across plasma membrane
A6J67_RS02150	COG0596	Alpha beta hydrolase
A6J67_RS02160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6J67_RS02160	COG0316	Belongs to the HesB IscA family
A6J67_RS02165	COG1640	4-alpha-glucanotransferase
A6J67_RS02170	COG0058	SHG alpha-glucan phosphorylase activity
A6J67_RS02175	COG2909	trisaccharide binding
A6J67_RS02185	COG0705	Rhomboid family
A6J67_RS02190	COG1349	DNA-binding transcription factor activity
A6J67_RS02195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J67_RS02200	COG0058	SHG alpha-glucan phosphorylase activity
A6J67_RS02205	COG0297	glycogen (starch) synthase activity
A6J67_RS02210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J67_RS02215	COG1523	belongs to the glycosyl hydrolase 13 family
A6J67_RS02220	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J67_RS02225	COG3275	phosphorelay sensor kinase activity
A6J67_RS02245	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J67_RS02250	COG2095	MarC family integral membrane protein
A6J67_RS02255	COG3265	gluconokinase activity
A6J67_RS02260	COG2610	gluconate transmembrane transporter activity
A6J67_RS02265	COG1609	Transcriptional regulator
A6J67_RS02270	COG1741	Belongs to the pirin family
A6J67_RS02275	COG1247	-acetyltransferase
A6J67_RS02280	COG1082	Xylose isomerase domain protein TIM barrel
A6J67_RS02285	COG0673	inositol 2-dehydrogenase activity
A6J67_RS02290	COG3962	Belongs to the TPP enzyme family
A6J67_RS02305	COG3718	enzyme involved in inositol metabolism
A6J67_RS02320	COG2814	Major facilitator Superfamily
A6J67_RS02325	COG0583	DNA-binding transcription factor activity
A6J67_RS02340	COG2081	HI0933 family
A6J67_RS02345	COG0306	phosphate transporter
A6J67_RS02355	COG0589	response to stress
A6J67_RS02365	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A6J67_RS02370	COG0742	ribosomal rna small subunit methyltransferase
A6J67_RS02385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6J67_RS02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J67_RS02415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J67_RS02475	COG1396	sequence-specific DNA binding
A6J67_RS02480	COG1295	ribonuclease BN
A6J67_RS02485	COG2134	cdp-diacylglycerol pyrophosphatase
A6J67_RS02490	COG2982	Protein involved in outer membrane biogenesis
A6J67_RS02495	COG2200	EAL domain
A6J67_RS02500	COG1942	4-Oxalocrotonate Tautomerase
A6J67_RS02505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J67_RS02510	COG0612	Peptidase, M16
A6J67_RS02515	COG1301	dicarboxylic acid transport
A6J67_RS02530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6J67_RS02540	COG3188	usher protein
A6J67_RS02545	COG3121	Chaperone
A6J67_RS02555	COG2200	EAL domain
A6J67_RS02555	COG2199	diguanylate cyclase activity
A6J67_RS02560	COG3118	belongs to the thioredoxin family
A6J67_RS02560	COG0457	Tetratricopeptide repeat
A6J67_RS02565	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A6J67_RS02570	COG1215	transferase activity, transferring glycosyl groups
A6J67_RS02580	COG1192	Involved in chromosome partitioning
A6J67_RS02600	COG2194	sulfuric ester hydrolase activity
A6J67_RS02605	COG4608	Belongs to the ABC transporter superfamily
A6J67_RS02610	COG0444	Belongs to the ABC transporter superfamily
A6J67_RS02615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J67_RS02620	COG0601	transmembrane transport
A6J67_RS02625	COG0747	negative chemotaxis
A6J67_RS02640	COG2271	Major facilitator Superfamily
A6J67_RS02645	COG3851	Histidine kinase
A6J67_RS02650	COG2197	response regulator
A6J67_RS02655	COG2194	sulfuric ester hydrolase activity
A6J67_RS02660	COG1764	response to oxidative stress
A6J67_RS02680	COG2986	histidine ammonia-lyase
A6J67_RS02685	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6J67_RS02695	COG2207	Transcriptional regulator
A6J67_RS02695	COG1609	Transcriptional regulator
A6J67_RS02700	COG4214	carbohydrate transport
A6J67_RS02710	COG4213	ABC transporter substrate-binding protein
A6J67_RS02715	COG2115	Belongs to the xylose isomerase family
A6J67_RS02720	COG1070	Carbohydrate kinase
A6J67_RS02730	COG3121	Chaperone
A6J67_RS02735	COG3188	usher protein
A6J67_RS02745	COG1335	isochorismatase
A6J67_RS02755	COG3274	enterobacterial common antigen metabolic process
A6J67_RS02765	COG3276	selenocysteine insertion sequence binding
A6J67_RS02775	COG3058	Necessary for formate dehydrogenase activity
A6J67_RS02780	COG2864	formate dehydrogenase
A6J67_RS02785	COG0437	4 iron, 4 sulfur cluster binding
A6J67_RS02790	COG3383	formate dehydrogenase (NAD+) activity
A6J67_RS02790	COG0243	molybdopterin cofactor binding
A6J67_RS02795	COG3383	formate dehydrogenase (NAD+) activity
A6J67_RS02795	COG0243	molybdopterin cofactor binding
A6J67_RS02800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J67_RS02805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J67_RS02810	COG0840	transmembrane signaling receptor activity
A6J67_RS02815	COG2258	MOSC domain
A6J67_RS02820	COG3077	Addiction module antitoxin, RelB DinJ family
A6J67_RS02835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J67_RS02845	COG3722	fumarate hydratase activity
A6J67_RS02850	COG0246	Mannitol dehydrogenase
A6J67_RS02855	COG2213	PTS system mannitol-specific
A6J67_RS02855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS02870	COG0751	glycine-tRNA ligase activity
A6J67_RS02880	COG2818	Glycosylase
A6J67_RS02885	COG0456	acetyltransferase
A6J67_RS02900	COG2885	chlorophyll binding
A6J67_RS02920	COG0366	Alpha amylase catalytic
A6J67_RS02925	COG3977	Valine--pyruvate aminotransferase
A6J67_RS02945	COG5645	(Lipo)protein
A6J67_RS02950	COG0823	Involved in the tonB-independent uptake of proteins
A6J67_RS02955	COG2271	Major facilitator Superfamily
A6J67_RS02960	COG4948	Mandelate Racemase Muconate Lactonizing
A6J67_RS02965	COG0800	Aldolase
A6J67_RS02970	COG3734	2-keto-3-deoxy-galactonokinase
A6J67_RS02975	COG2186	Transcriptional regulator
A6J67_RS02985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J67_RS02990	COG2423	ornithine cyclodeaminase activity
A6J67_RS02995	COG2188	Transcriptional regulator
A6J67_RS03000	COG2723	6-phospho-beta-galactosidase activity
A6J67_RS03010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J67_RS03015	COG1940	carbohydrate kinase activity
A6J67_RS03025	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J67_RS03030	COG0561	phosphatase activity
A6J67_RS03035	COG0187	DNA topoisomerase II activity
A6J67_RS03045	COG0592	DNA-directed DNA polymerase activity
A6J67_RS03050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J67_RS03060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6J67_RS03065	COG0594	ribonuclease P activity
A6J67_RS03075	COG0706	membrane insertase activity
A6J67_RS03080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J67_RS03085	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J67_RS03095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J67_RS03100	COG2011	ABC-type metal ion transport system permease component
A6J67_RS03105	COG0840	transmembrane signaling receptor activity
A6J67_RS03110	COG0431	NADPH-dependent FMN reductase
A6J67_RS03115	COG4191	Histidine kinase
A6J67_RS03130	COG2252	PERMEase
A6J67_RS03135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J67_RS03140	COG0765	amino acid transport
A6J67_RS03145	COG0765	amino acid transport
A6J67_RS03150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS03160	COG0704	Plays a role in the regulation of phosphate uptake
A6J67_RS03170	COG0581	inorganic phosphate transmembrane transporter activity
A6J67_RS03175	COG0573	inorganic phosphate transmembrane transporter activity
A6J67_RS03185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J67_RS03235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J67_RS03240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J67_RS03245	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J67_RS03255	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J67_RS03260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J67_RS03265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J67_RS03275	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J67_RS03280	COG3312	ion transport
A6J67_RS03285	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J67_RS03290	COG0445	tRNA wobble uridine modification
A6J67_RS03295	COG0716	FMN binding
A6J67_RS03300	COG1522	sequence-specific DNA binding
A6J67_RS03305	COG2502	aspartate--ammonia ligase
A6J67_RS03315	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A6J67_RS03320	COG0714	Associated with various cellular activities
A6J67_RS03325	COG3158	transport of potassium into the cell
A6J67_RS03330	COG1869	D-ribose catabolic process
A6J67_RS03340	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS03345	COG1879	ABC-type sugar transport system periplasmic component
A6J67_RS03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J67_RS03355	COG1609	Transcriptional regulator
A6J67_RS03360	COG0477	Major facilitator Superfamily
A6J67_RS03365	COG2186	Transcriptional regulator
A6J67_RS03390	COG1763	Mo-molybdopterin cofactor biosynthetic process
A6J67_RS03400	COG3084	Protein conserved in bacteria
A6J67_RS03405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6J67_RS03410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J67_RS03415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J67_RS03415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J67_RS03425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J67_RS03440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J67_RS03450	COG3852	Histidine kinase
A6J67_RS03460	COG0174	glutamine synthetase
A6J67_RS03470	COG1011	Hydrolase
A6J67_RS03480	COG1490	D-aminoacyl-tRNA deacylase activity
A6J67_RS03485	COG0456	acetyltransferase
A6J67_RS03490	COG2204	response regulator
A6J67_RS03505	COG3423	Transcriptional regulator
A6J67_RS03515	COG2982	Protein involved in outer membrane biogenesis
A6J67_RS03520	COG2233	PERMEase
A6J67_RS03525	COG0786	glutamate:sodium symporter activity
A6J67_RS03530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J67_RS03535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J67_RS03540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J67_RS03545	COG1758	RNA polymerase activity
A6J67_RS03555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J67_RS03560	COG2860	membrane
A6J67_RS03570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J67_RS03580	COG5001	Diguanylate cyclase
A6J67_RS03600	COG3645	SOS response
A6J67_RS03605	COG1561	YicC-like family, N-terminal region
A6J67_RS03610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6J67_RS03615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J67_RS03620	COG1309	transcriptional regulator
A6J67_RS03625	COG0756	dUTP diphosphatase activity
A6J67_RS03630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J67_RS03640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J67_RS03645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J67_RS03655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J67_RS03665	COG1519	Transferase
A6J67_RS03670	COG0859	PFAM glycosyl transferase family 9
A6J67_RS03680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J67_RS03685	COG0156	8-amino-7-oxononanoate synthase activity
A6J67_RS03695	COG2861	carbohydrate metabolic process
A6J67_RS03700	COG4942	peptidase
A6J67_RS03705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J67_RS03710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J67_RS03715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J67_RS03720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6J67_RS03725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J67_RS03730	COG1045	serine acetyltransferase
A6J67_RS03735	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J67_RS03740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J67_RS03740	COG2169	Transcriptional regulator
A6J67_RS03745	COG2205	protein histidine kinase activity
A6J67_RS03750	COG0745	RESPONSE REGULATOR receiver
A6J67_RS03755	COG3678	ATP-independent chaperone mediated protein folding
A6J67_RS03770	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
A6J67_RS03785	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J67_RS03795	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A6J67_RS03810	COG3152	Membrane
A6J67_RS03825	COG1494	fructose-1,6-bisphosphatase
A6J67_RS03830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J67_RS03835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J67_RS03850	COG3074	FtsZ-dependent cytokinesis
A6J67_RS03860	COG1575	Belongs to the MenA family. Type 1 subfamily
A6J67_RS03865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6J67_RS03870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6J67_RS03875	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J67_RS03880	COG1609	Transcriptional regulator
A6J67_RS03885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J67_RS03890	COG0254	rRNA binding
A6J67_RS03895	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6J67_RS03900	COG0626	cystathionine gamma-synthase activity
A6J67_RS03905	COG0460	homoserine dehydrogenase
A6J67_RS03905	COG0527	aspartate kinase activity
A6J67_RS03915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J67_RS03940	COG0165	Argininosuccinate lyase
A6J67_RS03990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J67_RS03995	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J67_RS03995	COG0678	peroxiredoxin activity
A6J67_RS04005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J67_RS04020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J67_RS04030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J67_RS04070	COG1879	ABC-type sugar transport system periplasmic component
A6J67_RS04075	COG1129	ABC transporter
A6J67_RS04080	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS04085	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS04090	COG0583	DNA-binding transcription factor activity
A6J67_RS04095	COG3085	chromosome segregation
A6J67_RS04120	COG3978	acetolactate synthase activity
A6J67_RS04125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J67_RS04135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J67_RS04145	COG0583	DNA-binding transcription factor activity
A6J67_RS04150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J67_RS04160	COG3121	Chaperone
A6J67_RS04175	COG3121	Chaperone
A6J67_RS04185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J67_RS04200	COG0248	Ppx GppA phosphatase
A6J67_RS04210	COG3118	belongs to the thioredoxin family
A6J67_RS04215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6J67_RS04225	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A6J67_RS04230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6J67_RS04235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6J67_RS04240	COG1088	dTDP-glucose 4,6-dehydratase activity
A6J67_RS04245	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J67_RS04250	COG0456	acetyltransferase
A6J67_RS04255	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J67_RS04260	COG2244	polysaccharide biosynthetic process
A6J67_RS04265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J67_RS04305	COG3071	HemY protein
A6J67_RS04310	COG2959	enzyme of heme biosynthesis
A6J67_RS04315	COG1587	Uroporphyrinogen-III synthase
A6J67_RS04320	COG0181	hydroxymethylbilane synthase activity
A6J67_RS04330	COG3072	Adenylate cyclase
A6J67_RS04340	COG5567	small periplasmic lipoprotein
A6J67_RS04345	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6J67_RS04350	COG3159	Protein conserved in bacteria
A6J67_RS04355	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6J67_RS04360	COG1011	Hydrolase
A6J67_RS04365	COG0210	DNA helicase
A6J67_RS04375	COG5441	Belongs to the UPF0261 family
A6J67_RS04380	COG5564	TIM-barrel signal transduction protein
A6J67_RS04400	COG2050	protein possibly involved in aromatic compounds catabolism
A6J67_RS04405	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A6J67_RS04410	COG0514	ATP-dependent DNA helicase (RecQ)
A6J67_RS04415	COG1280	lysine exporter protein (LysE YggA)
A6J67_RS04420	COG1280	lysine exporter protein (LysE YggA)
A6J67_RS04425	COG2267	carboxylic ester hydrolase activity
A6J67_RS04435	COG0584	glycerophosphoryl diester phosphodiesterase
A6J67_RS04440	COG2271	Major facilitator Superfamily
A6J67_RS04445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J67_RS04450	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A6J67_RS04455	COG0247	lactate metabolic process
A6J67_RS04465	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6J67_RS04470	COG0425	Belongs to the sulfur carrier protein TusA family
A6J67_RS04475	COG2217	Heavy metal translocating P-type atpase
A6J67_RS04480	COG3714	YhhN family
A6J67_RS04495	COG3776	membrane
A6J67_RS04500	COG0742	ribosomal rna small subunit methyltransferase
A6J67_RS04505	COG0552	protein localization to endoplasmic reticulum
A6J67_RS04510	COG2884	Cell division ATP-binding protein ftsE
A6J67_RS04515	COG2177	Part of the ABC transporter FtsEX involved in
A6J67_RS04525	COG0456	acetyltransferase
A6J67_RS04530	COG0683	leucine binding
A6J67_RS04540	COG4177	L-phenylalanine transmembrane transporter activity
A6J67_RS04550	COG0410	ABC transporter
A6J67_RS04585	COG1653	transport
A6J67_RS04590	COG1175	transmembrane transport
A6J67_RS04595	COG0395	ABC-type sugar transport system, permease component
A6J67_RS04600	COG3842	ATPase activity
A6J67_RS04605	COG0584	glycerophosphoryl diester phosphodiesterase
A6J67_RS04610	COG0679	Auxin Efflux Carrier
A6J67_RS04615	COG0697	spore germination
A6J67_RS04620	COG0583	DNA-binding transcription factor activity
A6J67_RS04625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J67_RS04630	COG0412	Dienelactone hydrolase
A6J67_RS04645	COG1966	Carbon starvation protein
A6J67_RS04650	COG0586	Pfam SNARE associated Golgi protein
A6J67_RS04655	COG1322	Protein conserved in bacteria
A6J67_RS04660	COG2226	methyltransferase
A6J67_RS04665	COG3165	ubiquinone biosynthetic process from chorismate
A6J67_RS04670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6J67_RS04675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J67_RS04680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J67_RS04685	COG0805	protein transport
A6J67_RS04705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6J67_RS04715	COG0183	Belongs to the thiolase family
A6J67_RS04730	COG1739	Uncharacterized protein family UPF0029
A6J67_RS04735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J67_RS04770	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6J67_RS04770	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6J67_RS04775	COG1072	(Pantothenic acid kinase))
A6J67_RS04820	COG0250	Participates in transcription elongation, termination and antitermination
A6J67_RS04825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J67_RS04830	COG0081	regulation of translation
A6J67_RS04835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J67_RS04840	COG0222	ribosome binding
A6J67_RS04845	COG0085	RNA polymerase activity
A6J67_RS04850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J67_RS04860	COG2022	thiamine diphosphate biosynthetic process
A6J67_RS04865	COG2104	thiamine diphosphate biosynthetic process
A6J67_RS04870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6J67_RS04890	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6J67_RS04895	COG2816	NAD+ diphosphatase activity
A6J67_RS04900	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6J67_RS04905	COG1515	deoxyribonuclease V activity
A6J67_RS04925	COG0151	Belongs to the GarS family
A6J67_RS04930	COG0138	bifunctional purine biosynthesis protein purh
A6J67_RS04965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J67_RS04970	COG3162	membrane
A6J67_RS04975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J67_RS04980	COG1301	dicarboxylic acid transport
A6J67_RS05060	COG0425	Belongs to the sulfur carrier protein TusA family
A6J67_RS05065	COG3264	Mechanosensitive ion channel
A6J67_RS05065	COG1511	domain protein
A6J67_RS05070	COG4774	siderophore transport
A6J67_RS05080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J67_RS05085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6J67_RS05090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J67_RS05095	COG4558	Periplasmic binding protein
A6J67_RS05100	COG3720	iron ion transport
A6J67_RS05115	COG0488	(ABC) transporter
A6J67_RS05125	COG0814	amino acid
A6J67_RS05130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J67_RS05135	COG1882	Formate acetyltransferase
A6J67_RS05140	COG0840	transmembrane signaling receptor activity
A6J67_RS05150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS05150	COG1263	PTS System
A6J67_RS05155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6J67_RS05165	COG1472	Belongs to the glycosyl hydrolase 3 family
A6J67_RS05175	COG3876	Protein conserved in bacteria
A6J67_RS05185	COG1309	transcriptional regulator
A6J67_RS05195	COG2084	Dehydrogenase
A6J67_RS05200	COG1929	Belongs to the glycerate kinase type-1 family
A6J67_RS05205	COG3835	regulator
A6J67_RS05210	COG2721	sulfolactate sulfo-lyase activity
A6J67_RS05215	COG2271	Major facilitator Superfamily
A6J67_RS05220	COG0493	'glutamate synthase
A6J67_RS05220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS05225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS05230	COG3383	formate dehydrogenase (NAD+) activity
A6J67_RS05235	COG4232	protein-disulfide reductase activity
A6J67_RS05245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J67_RS05260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J67_RS05265	COG0459	protein refolding
A6J67_RS05300	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6J67_RS05305	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6J67_RS05310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J67_RS05315	COG1053	succinate dehydrogenase
A6J67_RS05320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6J67_RS05325	COG1511	domain protein
A6J67_RS05325	COG3264	Mechanosensitive ion channel
A6J67_RS05330	COG0688	phosphatidylethanolamine metabolic process
A6J67_RS05335	COG1162	GTPase activity
A6J67_RS05340	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6J67_RS05370	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J67_RS05375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6J67_RS05375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J67_RS05380	COG0802	atpase or kinase
A6J67_RS05385	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J67_RS05405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J67_RS05410	COG0330	HflC and HflK could
A6J67_RS05415	COG0330	HflC and HflK could
A6J67_RS05420	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6J67_RS05425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J67_RS05430	COG1959	2 iron, 2 sulfur cluster binding
A6J67_RS05440	COG0557	exoribonuclease II activity
A6J67_RS05445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J67_RS05455	COG3650	response to hydrogen peroxide
A6J67_RS05460	COG1073	alpha beta
A6J67_RS05480	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J67_RS05485	COG2965	DNA replication, synthesis of RNA primer
A6J67_RS05490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J67_RS05495	COG0359	binds to the 23S rRNA
A6J67_RS05505	COG3061	Opacity-associated protein A
A6J67_RS05510	COG0545	Peptidyl-prolyl cis-trans isomerase
A6J67_RS05520	COG0737	Belongs to the 5'-nucleotidase family
A6J67_RS05525	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6J67_RS05530	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6J67_RS05540	COG1253	flavin adenine dinucleotide binding
A6J67_RS05545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J67_RS05550	COG0729	surface antigen
A6J67_RS05555	COG2911	Protein conserved in bacteria
A6J67_RS05560	COG2105	PFAM AIG2 family protein
A6J67_RS05565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6J67_RS05570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6J67_RS05575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J67_RS05600	COG3423	Transcriptional regulator
A6J67_RS05615	COG0142	geranyltranstransferase activity
A6J67_RS05630	COG0697	spore germination
A6J67_RS05635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J67_RS05640	COG0642	Histidine kinase
A6J67_RS05645	COG0745	RESPONSE REGULATOR receiver
A6J67_RS05660	COG1534	Rna-binding protein
A6J67_RS05665	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6J67_RS05675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J67_RS05685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J67_RS05705	COG0195	Participates in both transcription termination and antitermination
A6J67_RS05715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J67_RS05720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J67_RS05730	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J67_RS05740	COG0513	Belongs to the DEAD box helicase family
A6J67_RS05745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6J67_RS05750	COG0826	peptidase U32
A6J67_RS05755	COG0826	peptidase U32
A6J67_RS05760	COG3154	lipid carrier protein
A6J67_RS05765	COG3153	acetyltransferase
A6J67_RS05770	COG2827	Endonuclease containing a URI domain
A6J67_RS05775	COG0531	amino acid
A6J67_RS05780	COG1982	Orn Lys Arg decarboxylase major
A6J67_RS05785	COG3787	Belongs to the UPF0306 family
A6J67_RS05790	COG0702	epimerase
A6J67_RS05795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J67_RS05800	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A6J67_RS05805	COG3454	Phosphonate metabolism
A6J67_RS05810	COG4778	phosphonate C-P lyase system protein PhnL
A6J67_RS05815	COG4107	phosphonate C-P lyase system protein PhnK
A6J67_RS05825	COG3626	phosphonate metabolism
A6J67_RS05830	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A6J67_RS05835	COG3624	Phosphonate C-P lyase system protein PhnG
A6J67_RS05840	COG2188	Transcriptional regulator
A6J67_RS05860	COG0583	DNA-binding transcription factor activity
A6J67_RS05865	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J67_RS05870	COG4608	Belongs to the ABC transporter superfamily
A6J67_RS05875	COG0444	Belongs to the ABC transporter superfamily
A6J67_RS05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J67_RS05885	COG0601	transmembrane transport
A6J67_RS05895	COG2731	YhcH YjgK YiaL family protein
A6J67_RS05905	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A6J67_RS05920	COG2927	DNA polymerase III (CHI subunit)
A6J67_RS05925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J67_RS05930	COG0795	lipopolysaccharide-transporting ATPase activity
A6J67_RS05935	COG0795	lipopolysaccharide-transporting ATPase activity
A6J67_RS05945	COG0582	viral genome integration into host DNA
A6J67_RS06005	COG4983	Phage plasmid primase, P4 family domain protein
A6J67_RS06020	COG3596	GTP binding
A6J67_RS06055	COG2003	Belongs to the UPF0758 family
A6J67_RS06120	COG1470	cell adhesion involved in biofilm formation
A6J67_RS06120	COG1388	LysM domain
A6J67_RS06140	COG3188	usher protein
A6J67_RS06185	COG3210	domain, Protein
A6J67_RS06210	COG3210	domain, Protein
A6J67_RS06230	COG0582	viral genome integration into host DNA
A6J67_RS06240	COG3210	domain, Protein
A6J67_RS06280	COG2826	transposase and inactivated derivatives, IS30 family
A6J67_RS06315	COG3210	domain, Protein
A6J67_RS06335	COG3210	domain, Protein
A6J67_RS06340	COG2831	hemolysin activation secretion protein
A6J67_RS06365	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J67_RS06380	COG3272	Protein of unknown function (DUF1722)
A6J67_RS06405	COG0642	Histidine kinase
A6J67_RS06415	COG1830	Aldolase
A6J67_RS06420	COG1879	ABC-type sugar transport system periplasmic component
A6J67_RS06425	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS06430	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS06435	COG1129	ABC transporter
A6J67_RS06440	COG2390	Transcriptional regulator
A6J67_RS06445	COG1070	Carbohydrate kinase
A6J67_RS06450	COG0859	PFAM glycosyl transferase family 9
A6J67_RS06470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS06475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J67_RS06485	COG2376	Dihydroxyacetone kinase
A6J67_RS06490	COG1461	Dihydroxyacetone kinase
A6J67_RS06495	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6J67_RS06495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J67_RS06495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS06595	COG0667	Aldo Keto reductase
A6J67_RS06605	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A6J67_RS06610	COG0456	acetyltransferase
A6J67_RS06615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6J67_RS06620	COG2823	Periplasmic or secreted lipoprotein
A6J67_RS06630	COG4667	esterase of the alpha-beta hydrolase superfamily
A6J67_RS06635	COG0084	hydrolase, TatD family'
A6J67_RS06640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J67_RS06650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6J67_RS06655	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6J67_RS06670	COG3550	peptidyl-serine autophosphorylation
A6J67_RS06675	COG3726	membrane protein affecting hemolysin expression
A6J67_RS06685	COG0560	Phosphoserine phosphatase
A6J67_RS06700	COG0604	alcohol dehydrogenase
A6J67_RS06715	COG1454	alcohol dehydrogenase
A6J67_RS06755	COG0488	(ABC) transporter
A6J67_RS06765	COG2885	chlorophyll binding
A6J67_RS06770	COG2199	diguanylate cyclase activity
A6J67_RS06780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J67_RS06785	COG0741	lytic transglycosylase activity
A6J67_RS06790	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A6J67_RS06795	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6J67_RS06805	COG2207	Transcriptional regulator
A6J67_RS06805	COG3708	Transcriptional regulator
A6J67_RS06810	COG3045	CreA protein
A6J67_RS06815	COG0745	RESPONSE REGULATOR receiver
A6J67_RS06830	COG0083	homoserine kinase activity
A6J67_RS06840	COG3022	response to hydroperoxide
A6J67_RS06845	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J67_RS06850	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6J67_RS06865	COG1584	GPR1 FUN34 yaaH family protein
A6J67_RS06875	COG0484	heat shock protein binding
A6J67_RS06880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J67_RS06885	COG0583	DNA-binding transcription factor activity
A6J67_RS06900	COG0196	riboflavin kinase activity
A6J67_RS06905	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J67_RS06910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J67_RS06915	COG1047	Peptidyl-prolyl cis-trans
A6J67_RS06920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6J67_RS06935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J67_RS06940	COG1280	lysine exporter protein (LysE YggA)
A6J67_RS06945	COG2966	Psort location CytoplasmicMembrane, score
A6J67_RS06955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J67_RS06960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J67_RS06965	COG2967	ApaG domain
A6J67_RS06970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J67_RS06985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6J67_RS06990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J67_RS06995	COG0564	pseudouridine synthase activity
A6J67_RS07000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J67_RS07010	COG0417	DNA replication proofreading
A6J67_RS07015	COG0586	Pfam SNARE associated Golgi protein
A6J67_RS07020	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6J67_RS07025	COG1178	ABC-type Fe3 transport system permease component
A6J67_RS07030	COG4143	(ABC) transporter
A6J67_RS07035	COG4533	DNA binding
A6J67_RS07040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J67_RS07045	COG1882	Formate acetyltransferase
A6J67_RS07050	COG2814	Major facilitator Superfamily
A6J67_RS07055	COG0814	amino acid
A6J67_RS07060	COG3033	Beta-eliminating lyase
A6J67_RS07075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J67_RS07080	COG0473	3-isopropylmalate dehydrogenase activity
A6J67_RS07085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J67_RS07090	COG0583	DNA-binding transcription factor activity
A6J67_RS07095	COG1022	Amp-dependent synthetase and ligase
A6J67_RS07100	COG0028	Belongs to the TPP enzyme family
A6J67_RS07125	COG0275	rRNA processing
A6J67_RS07130	COG3116	cell division
A6J67_RS07135	COG0768	penicillin binding
A6J67_RS07140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J67_RS07145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J67_RS07150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J67_RS07160	COG0772	Belongs to the SEDS family
A6J67_RS07165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J67_RS07170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J67_RS07180	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J67_RS07185	COG0849	cell division
A6J67_RS07190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J67_RS07210	COG0653	protein targeting
A6J67_RS07215	COG0494	nUDIX hydrolase
A6J67_RS07220	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6J67_RS07240	COG0516	GMP reductase activity
A6J67_RS07245	COG1459	type II secretion system
A6J67_RS07250	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J67_RS07255	COG4969	Belongs to the N-Me-Phe pilin family
A6J67_RS07270	COG3725	Membrane protein required for beta-lactamase induction
A6J67_RS07275	COG1113	amino acid transport
A6J67_RS07285	COG2186	Transcriptional regulator
A6J67_RS07290	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6J67_RS07295	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J67_RS07300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J67_RS07315	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6J67_RS07320	COG3112	Uncharacterised protein family (UPF0231)
A6J67_RS07330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A6J67_RS07335	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6J67_RS07345	COG2132	Multicopper oxidase
A6J67_RS07350	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6J67_RS07355	COG0288	reversible hydration of carbon dioxide
A6J67_RS07360	COG1131	(ABC) transporter
A6J67_RS07365	COG0842	Transport permease protein
A6J67_RS07370	COG0726	polysaccharide deacetylase
A6J67_RS07375	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A6J67_RS07385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6J67_RS07390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6J67_RS07395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J67_RS07400	COG0617	tRNA 3'-terminal CCA addition
A6J67_RS07415	COG1489	DNA binding
A6J67_RS07420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A6J67_RS07425	COG1643	Atp-dependent helicase
A6J67_RS07430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J67_RS07435	COG1120	ATPase activity
A6J67_RS07440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J67_RS07445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J67_RS07450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6J67_RS07460	COG0316	Belongs to the HesB IscA family
A6J67_RS07465	COG2860	membrane
A6J67_RS07475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J67_RS07480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6J67_RS07485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J67_RS07495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J67_RS07500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J67_RS07505	COG3956	TIGRFAM MazG family protein
A6J67_RS07510	COG0504	CTP synthase activity
A6J67_RS07515	COG0148	phosphopyruvate hydratase activity
A6J67_RS07525	COG0602	queuosine metabolic process
A6J67_RS07530	COG0720	synthase
A6J67_RS07535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6J67_RS07545	COG0175	sulfate reduction
A6J67_RS07565	COG2234	aminopeptidase activity
A6J67_RS07575	COG0175	sulfate reduction
A6J67_RS07580	COG2895	sulfate adenylyltransferase (ATP) activity
A6J67_RS07585	COG0529	Catalyzes the synthesis of activated sulfate
A6J67_RS07600	COG0765	amino acid transport
A6J67_RS07610	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6J67_RS07620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6J67_RS07625	COG0585	pseudouridine synthase activity
A6J67_RS07630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6J67_RS07635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J67_RS07640	COG1388	LysM domain
A6J67_RS07640	COG4942	peptidase
A6J67_RS07645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J67_RS07650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J67_RS07675	COG0084	hydrolase, TatD family'
A6J67_RS07750	COG1196	nuclear chromosome segregation
A6J67_RS07785	COG3188	usher protein
A6J67_RS07790	COG3121	Chaperone
A6J67_RS07805	COG3539	Fimbrial protein
A6J67_RS07825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J67_RS07840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS07845	COG0577	efflux transmembrane transporter activity
A6J67_RS07845	COG1136	(ABC) transporter
A6J67_RS07850	COG1538	Outer membrane efflux protein
A6J67_RS07870	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS07875	COG4948	Mandelate Racemase Muconate Lactonizing
A6J67_RS07880	COG0747	negative chemotaxis
A6J67_RS07885	COG0601	transmembrane transport
A6J67_RS07890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J67_RS07895	COG0444	Belongs to the ABC transporter superfamily
A6J67_RS07900	COG4608	Belongs to the ABC transporter superfamily
A6J67_RS07905	COG0583	DNA-binding transcription factor activity
A6J67_RS07910	COG2610	gluconate transmembrane transporter activity
A6J67_RS07915	COG3048	D-serine ammonia-lyase activity
A6J67_RS07920	COG3158	transport of potassium into the cell
A6J67_RS07925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J67_RS07930	COG0640	Transcriptional regulator
A6J67_RS07985	COG0410	ABC transporter
A6J67_RS07990	COG1137	ATPase activity
A6J67_RS07995	COG4177	L-phenylalanine transmembrane transporter activity
A6J67_RS08010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J67_RS08010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J67_RS08015	COG1070	Carbohydrate kinase
A6J67_RS08020	COG3623	hexulose-6-phosphate isomerase
A6J67_RS08025	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS08030	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS08045	COG1349	DNA-binding transcription factor activity
A6J67_RS08050	COG0235	Class ii aldolase
A6J67_RS08055	COG1349	DNA-binding transcription factor activity
A6J67_RS08065	COG1070	Carbohydrate kinase
A6J67_RS08075	COG0738	Major facilitator superfamily
A6J67_RS08080	COG0235	Class ii aldolase
A6J67_RS08085	COG1454	alcohol dehydrogenase
A6J67_RS08090	COG0243	molybdopterin cofactor binding
A6J67_RS08095	COG0437	4 iron, 4 sulfur cluster binding
A6J67_RS08100	COG3302	dmso reductase anchor subunit
A6J67_RS08105	COG3381	protein complex oligomerization
A6J67_RS08120	COG1879	ABC-type sugar transport system periplasmic component
A6J67_RS08130	COG1129	ABC transporter
A6J67_RS08140	COG3959	Transketolase, thiamine diphosphate binding domain
A6J67_RS08145	COG3958	Transketolase
A6J67_RS08150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J67_RS08175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J67_RS08180	COG2137	regulation of response to DNA damage stimulus
A6J67_RS08185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J67_RS08190	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6J67_RS08225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J67_RS08230	COG1238	metal cluster binding
A6J67_RS08235	COG2918	glutathione biosynthetic process
A6J67_RS08240	COG1854	S-ribosylhomocysteine lyase activity
A6J67_RS08245	COG4536	flavin adenine dinucleotide binding
A6J67_RS08250	COG4137	Cytochrome C assembly protein
A6J67_RS08255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J67_RS08260	COG0228	four-way junction DNA binding
A6J67_RS08270	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J67_RS08275	COG0335	large ribosomal subunit rRNA binding
A6J67_RS08280	COG3137	Salt-induced outer membrane protein
A6J67_RS08285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J67_RS08290	COG3279	Response regulator of the LytR AlgR family
A6J67_RS08295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J67_RS08300	COG1605	Chorismate mutase
A6J67_RS08300	COG0287	Prephenate dehydrogenase
A6J67_RS08305	COG1605	Chorismate mutase
A6J67_RS08305	COG0077	Prephenate dehydratase
A6J67_RS08315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6J67_RS08320	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J67_RS08330	COG0564	pseudouridine synthase activity
A6J67_RS08340	COG0542	response to heat
A6J67_RS08395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J67_RS08410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J67_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS08465	COG0583	DNA-binding transcription factor activity
A6J67_RS08470	COG2814	Major facilitator Superfamily
A6J67_RS08475	COG3021	interspecies interaction between organisms
A6J67_RS08480	COG1388	LysM domain
A6J67_RS08480	COG0741	lytic transglycosylase activity
A6J67_RS08485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J67_RS08530	COG2113	Glycine betaine
A6J67_RS08535	COG4176	ABC-type proline glycine betaine transport system permease component
A6J67_RS08545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J67_RS08555	COG1780	Probably involved in ribonucleotide reductase function
A6J67_RS08560	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J67_RS08570	COG4575	ribosome binding
A6J67_RS08585	COG3708	Transcriptional regulator
A6J67_RS08585	COG2207	Transcriptional regulator
A6J67_RS08605	COG1278	Cold shock
A6J67_RS08635	COG0601	transmembrane transport
A6J67_RS08640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J67_RS08650	COG1124	(ABC) transporter
A6J67_RS08660	COG0831	urea catabolic process
A6J67_RS08670	COG0804	urea catabolic process
A6J67_RS08675	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A6J67_RS08680	COG0830	nickel cation binding
A6J67_RS08685	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6J67_RS08695	COG4413	Urea transporter
A6J67_RS08700	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A6J67_RS08710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J67_RS08725	COG0667	Aldo Keto reductase
A6J67_RS08730	COG2133	pyrroloquinoline quinone binding
A6J67_RS08735	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J67_RS08740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J67_RS08745	COG2723	6-phospho-beta-galactosidase activity
A6J67_RS08750	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J67_RS08755	COG1917	Cupin 2, conserved barrel domain protein
A6J67_RS08755	COG2169	Transcriptional regulator
A6J67_RS08760	COG3394	polysaccharide catabolic process
A6J67_RS08785	COG0582	viral genome integration into host DNA
A6J67_RS08795	COG3299	homolog of phage Mu protein gp47
A6J67_RS08800	COG3778	Protein conserved in bacteria
A6J67_RS08820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J67_RS08830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J67_RS08835	COG2867	negative regulation of translational initiation
A6J67_RS08845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J67_RS08850	COG0497	DNA recombination
A6J67_RS08855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J67_RS08860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J67_RS08865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J67_RS08870	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6J67_RS08885	COG0513	Belongs to the DEAD box helicase family
A6J67_RS08890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J67_RS08895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6J67_RS08905	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A6J67_RS08910	COG3026	antisigma factor binding
A6J67_RS08915	COG3086	response to oxidative stress
A6J67_RS08925	COG0481	GTPase activity
A6J67_RS08940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J67_RS08945	COG1381	Involved in DNA repair and RecF pathway recombination
A6J67_RS08950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6J67_RS08955	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J67_RS08960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS08965	COG1737	Transcriptional regulator
A6J67_RS08975	COG0560	Phosphoserine phosphatase
A6J67_RS08990	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6J67_RS09005	COG2205	protein histidine kinase activity
A6J67_RS09010	COG3170	Tfp pilus assembly protein FimV
A6J67_RS09015	COG2204	response regulator
A6J67_RS09020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J67_RS09020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J67_RS09025	COG0347	Belongs to the P(II) protein family
A6J67_RS09040	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A6J67_RS09045	COG3457	Alanine racemase
A6J67_RS09055	COG2188	Transcriptional regulator
A6J67_RS09060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J67_RS09060	COG1017	nitric oxide dioxygenase activity
A6J67_RS09070	COG2814	Major facilitator Superfamily
A6J67_RS09075	COG3711	transcriptional antiterminator
A6J67_RS09080	COG3683	transport system, periplasmic component
A6J67_RS09085	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A6J67_RS09095	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6J67_RS09100	COG1959	2 iron, 2 sulfur cluster binding
A6J67_RS09110	COG0822	iron-sulfur transferase activity
A6J67_RS09120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J67_RS09125	COG0443	Heat shock 70 kDa protein
A6J67_RS09130	COG0633	Ferredoxin
A6J67_RS09135	COG2975	iron-sulfur cluster assembly
A6J67_RS09150	COG3468	outer membrane autotransporter barrel domain protein
A6J67_RS09155	COG2373	Large extracellular alpha-helical protein
A6J67_RS09160	COG4953	penicillin-binding protein 1C
A6J67_RS09180	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J67_RS09190	COG1426	Protein conserved in bacteria
A6J67_RS09205	COG2976	Protein conserved in bacteria
A6J67_RS09210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J67_RS09225	COG1645	bacterial-type flagellum-dependent swarming motility
A6J67_RS09235	COG0517	IMP dehydrogenase activity
A6J67_RS09235	COG0516	GMP reductase activity
A6J67_RS09240	COG0519	Catalyzes the synthesis of GMP from XMP
A6J67_RS09240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6J67_RS09260	COG0351	phosphomethylpyrimidine kinase
A6J67_RS09280	COG1349	DNA-binding transcription factor activity
A6J67_RS09285	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS09305	COG3730	PTS system glucitol sorbitol-specific
A6J67_RS09315	COG0826	peptidase U32
A6J67_RS09320	COG3422	double-strand break repair
A6J67_RS09325	COG0745	RESPONSE REGULATOR receiver
A6J67_RS09330	COG2205	protein histidine kinase activity
A6J67_RS09335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J67_RS09345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS09350	COG0443	Heat shock 70 kDa protein
A6J67_RS09360	COG2239	Acts as a magnesium transporter
A6J67_RS09370	COG0248	Ppx GppA phosphatase
A6J67_RS09375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J67_RS09380	COG0573	inorganic phosphate transmembrane transporter activity
A6J67_RS09385	COG0581	inorganic phosphate transmembrane transporter activity
A6J67_RS09400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J67_RS09405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J67_RS09410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J67_RS09420	COG2233	PERMEase
A6J67_RS09425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J67_RS09430	COG1393	Belongs to the ArsC family
A6J67_RS09435	COG4783	chaperone-mediated protein folding
A6J67_RS09440	COG0628	permease
A6J67_RS09450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J67_RS09455	COG2716	regulation of RNA biosynthetic process
A6J67_RS09460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J67_RS09465	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6J67_RS09480	COG2321	neutral zinc metallopeptidase
A6J67_RS09490	COG1444	tRNA N-acetyltransferase activity
A6J67_RS09500	COG0400	carboxylic ester hydrolase activity
A6J67_RS09510	COG1876	peptidase activity
A6J67_RS09515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J67_RS09520	COG1393	Belongs to the ArsC family
A6J67_RS09530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J67_RS09540	COG2197	response regulator
A6J67_RS09545	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS09545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS09550	COG3062	negative regulation of establishment of protein localization
A6J67_RS09555	COG0243	molybdopterin cofactor binding
A6J67_RS09560	COG3043	anaerobic respiration
A6J67_RS09565	COG3005	denitrification pathway
A6J67_RS09580	COG0494	nUDIX hydrolase
A6J67_RS09590	COG1671	Belongs to the UPF0178 family
A6J67_RS09595	COG0408	coproporphyrinogen oxidase activity
A6J67_RS09600	COG0456	acetyltransferase
A6J67_RS09635	COG1309	transcriptional regulator
A6J67_RS09645	COG2814	Major facilitator Superfamily
A6J67_RS09705	COG0456	acetyltransferase
A6J67_RS09710	COG3111	PFAM Bacterial OB fold (BOF) protein
A6J67_RS09720	COG2837	iron assimilation
A6J67_RS09725	COG4150	thiosulfate binding
A6J67_RS09730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A6J67_RS09735	COG4208	sulfate ABC transporter
A6J67_RS09780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J67_RS09810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS09815	COG0745	RESPONSE REGULATOR receiver
A6J67_RS09820	COG2205	protein histidine kinase activity
A6J67_RS09840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS09850	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A6J67_RS09860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J67_RS09865	COG3530	Putative quorum-sensing-regulated virulence factor
A6J67_RS09895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J67_RS09940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J67_RS09945	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J67_RS09955	COG0667	Aldo Keto reductase
A6J67_RS09970	COG0837	glucose binding
A6J67_RS09975	COG2223	nitrite transmembrane transporter activity
A6J67_RS09980	COG3279	Response regulator of the LytR AlgR family
A6J67_RS09985	COG3275	phosphorelay sensor kinase activity
A6J67_RS10000	COG0436	Aminotransferase
A6J67_RS10005	COG3038	cytochrome b561
A6J67_RS10010	COG1598	PFAM Uncharacterised protein family UPF0150
A6J67_RS10020	COG3381	protein complex oligomerization
A6J67_RS10025	COG3302	dmso reductase anchor subunit
A6J67_RS10030	COG0437	4 iron, 4 sulfur cluster binding
A6J67_RS10035	COG0243	molybdopterin cofactor binding
A6J67_RS10050	COG2723	6-phospho-beta-galactosidase activity
A6J67_RS10080	COG2951	lytic endotransglycosylase activity
A6J67_RS10085	COG0531	amino acid
A6J67_RS10105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J67_RS10110	COG1127	ABC transporter
A6J67_RS10130	COG0626	cystathionine gamma-synthase activity
A6J67_RS10140	COG3038	cytochrome b561
A6J67_RS10145	COG2353	YceI-like domain
A6J67_RS10150	COG1757	Na H antiporter
A6J67_RS10160	COG1263	PTS System
A6J67_RS10160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS10175	COG1695	Transcriptional regulator
A6J67_RS10240	COG0582	viral genome integration into host DNA
A6J67_RS10250	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J67_RS10265	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J67_RS10270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J67_RS10275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J67_RS10280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6J67_RS10285	COG1138	Cytochrome C-type biogenesis protein
A6J67_RS10290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J67_RS10295	COG4235	cytochrome complex assembly
A6J67_RS10295	COG3088	subunit of a heme lyase
A6J67_RS10300	COG4235	cytochrome complex assembly
A6J67_RS10300	COG3088	subunit of a heme lyase
A6J67_RS10315	COG3691	Protein conserved in bacteria
A6J67_RS10320	COG0183	Belongs to the thiolase family
A6J67_RS10330	COG2062	phosphohistidine phosphatase, SixA
A6J67_RS10335	COG2840	Smr protein MutS2
A6J67_RS10340	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J67_RS10345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J67_RS10350	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6J67_RS10355	COG0730	response to heat
A6J67_RS10360	COG3101	peptidyl-lysine hydroxylation
A6J67_RS10370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J67_RS10370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J67_RS10375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J67_RS10385	COG1794	racemase activity, acting on amino acids and derivatives
A6J67_RS10395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J67_RS10420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J67_RS10425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J67_RS10450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J67_RS10460	COG0586	Pfam SNARE associated Golgi protein
A6J67_RS10470	COG0285	dihydrofolate synthase activity
A6J67_RS10475	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6J67_RS10480	COG1286	toxin biosynthetic process
A6J67_RS10485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J67_RS10495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS10500	COG4215	(ABC) transporter
A6J67_RS10510	COG4598	ABC transporter
A6J67_RS10515	COG1090	epimerase
A6J67_RS10525	COG0622	Phosphoesterase
A6J67_RS10530	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A6J67_RS10535	COG3037	sugar-specific permease SgaT UlaA
A6J67_RS10545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS10550	COG1609	Transcriptional regulator
A6J67_RS10555	COG0280	phosphate acetyltransferase
A6J67_RS10555	COG0857	belongs to the CobB CobQ family
A6J67_RS10565	COG3092	negative regulation of chromosome organization
A6J67_RS10575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J67_RS10580	COG0471	metal ion transport
A6J67_RS10580	COG0490	domain, Protein
A6J67_RS10585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6J67_RS10595	COG0436	Aminotransferase
A6J67_RS10600	COG0583	DNA-binding transcription factor activity
A6J67_RS10610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J67_RS10615	COG0649	NAD binding
A6J67_RS10615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J67_RS10630	COG1034	ATP synthesis coupled electron transport
A6J67_RS10635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6J67_RS10640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J67_RS10645	COG0839	Belongs to the complex I subunit 6 family
A6J67_RS10650	COG0713	ATP synthesis coupled electron transport
A6J67_RS10655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J67_RS10660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J67_RS10665	COG1007	ATP synthesis coupled electron transport
A6J67_RS10685	COG2731	YhcH YjgK YiaL family protein
A6J67_RS10690	COG3265	gluconokinase activity
A6J67_RS10695	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS10700	COG1609	Transcriptional regulator
A6J67_RS10705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J67_RS10715	COG4702	Belongs to the UPF0303 family
A6J67_RS10720	COG0129	dihydroxy-acid dehydratase activity
A6J67_RS10725	COG4575	ribosome binding
A6J67_RS10730	COG1169	isochorismate synthase
A6J67_RS10735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6J67_RS10745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6J67_RS10750	COG1441	menaquinone biosynthetic process
A6J67_RS10770	COG0814	amino acid
A6J67_RS10805	COG4574	serine-type endopeptidase inhibitor activity
A6J67_RS10810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J67_RS10820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J67_RS10825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J67_RS10835	COG2205	protein histidine kinase activity
A6J67_RS10835	COG0784	Response regulator, receiver
A6J67_RS10845	COG0642	Histidine kinase
A6J67_RS10845	COG2198	Histidine kinase
A6J67_RS10850	COG2223	nitrite transmembrane transporter activity
A6J67_RS10855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6J67_RS10865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J67_RS10865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS10865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS10875	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6J67_RS10935	COG3188	usher protein
A6J67_RS10950	COG1301	dicarboxylic acid transport
A6J67_RS10965	COG3799	methylaspartate ammonia-lyase activity
A6J67_RS10970	COG4865	methylaspartate mutase activity
A6J67_RS10980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J67_RS10990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6J67_RS10990	COG1648	precorrin-2 dehydrogenase activity
A6J67_RS10995	COG0583	DNA-binding transcription factor activity
A6J67_RS11000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J67_RS11000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A6J67_RS11015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J67_RS11065	COG3772	lysozyme
A6J67_RS11085	COG4386	tail sheath protein
A6J67_RS11125	COG3299	homolog of phage Mu protein gp47
A6J67_RS11150	COG1263	PTS System
A6J67_RS11150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS11150	COG2190	(PTS) system
A6J67_RS11155	COG2723	6-phospho-beta-galactosidase activity
A6J67_RS11160	COG3338	carbonate dehydratase activity
A6J67_RS11180	COG3082	Protein of unknown function (DUF1414)
A6J67_RS11185	COG3081	Nucleoid-associated protein
A6J67_RS11195	COG1061	Type III restriction enzyme res subunit
A6J67_RS11200	COG1187	pseudouridine synthase activity
A6J67_RS11210	COG2814	Major facilitator Superfamily
A6J67_RS11225	COG4172	Belongs to the ABC transporter superfamily
A6J67_RS11230	COG4239	(ABC) transporter, permease
A6J67_RS11235	COG4174	ABC transporter (Permease)
A6J67_RS11240	COG4166	transmembrane transport
A6J67_RS11245	COG2200	EAL domain
A6J67_RS11250	COG0791	NLP P60 protein
A6J67_RS11255	COG0671	phosphoesterase, PA-phosphatase related
A6J67_RS11260	COG0523	cobalamin synthesis protein
A6J67_RS11270	COG2186	Transcriptional regulator
A6J67_RS11275	COG0246	Mannitol dehydrogenase
A6J67_RS11290	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J67_RS11315	COG2222	sugar isomerase
A6J67_RS11320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J67_RS11325	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS11330	COG3716	PTS system mannose fructose sorbose family IID component
A6J67_RS11340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS11350	COG1349	DNA-binding transcription factor activity
A6J67_RS11355	COG0243	molybdopterin cofactor binding
A6J67_RS11360	COG3005	denitrification pathway
A6J67_RS11375	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J67_RS11380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6J67_RS11380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J67_RS11380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J67_RS11385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6J67_RS11390	COG2855	membrane
A6J67_RS11400	COG0583	DNA-binding transcription factor activity
A6J67_RS11405	COG0833	amino acid
A6J67_RS11415	COG0625	glutathione transferase activity
A6J67_RS11440	COG2011	ABC-type metal ion transport system permease component
A6J67_RS11445	COG0626	cystathionine gamma-synthase activity
A6J67_RS11455	COG1686	Belongs to the peptidase S11 family
A6J67_RS11460	COG1760	l-serine dehydratase
A6J67_RS11465	COG0814	amino acid
A6J67_RS11470	COG1349	DNA-binding transcription factor activity
A6J67_RS11480	COG0671	phosphoesterase, PA-phosphatase related
A6J67_RS11490	COG0569	domain protein
A6J67_RS11490	COG2985	domain, Protein
A6J67_RS11510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6J67_RS11515	COG3842	ATPase activity
A6J67_RS11520	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J67_RS11525	COG1177	transmembrane transport
A6J67_RS11540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS11545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J67_RS11550	COG1454	alcohol dehydrogenase
A6J67_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
A6J67_RS11560	COG1414	Transcriptional regulator
A6J67_RS11565	COG4160	amino acid transport
A6J67_RS11570	COG4215	(ABC) transporter
A6J67_RS11575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS11580	COG1126	abc transporter atp-binding protein
A6J67_RS11595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J67_RS11600	COG0702	epimerase
A6J67_RS11605	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A6J67_RS11615	COG0028	Belongs to the TPP enzyme family
A6J67_RS11620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J67_RS11625	COG1151	hydroxylamine reductase activity
A6J67_RS11630	COG2431	L-lysine efflux transmembrane transporter activity
A6J67_RS11635	COG3593	DNA synthesis involved in DNA repair
A6J67_RS11640	COG2990	Protein conserved in bacteria
A6J67_RS11645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS11655	COG1278	Cold shock
A6J67_RS11660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6J67_RS11665	COG0542	response to heat
A6J67_RS11670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J67_RS11680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6J67_RS11690	COG0492	ferredoxin-NADP+ reductase activity
A6J67_RS11700	COG3107	peptidoglycan biosynthetic process
A6J67_RS11700	COG1674	ftsk spoiiie
A6J67_RS11705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6J67_RS11710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J67_RS11715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J67_RS11720	COG2814	Major facilitator Superfamily
A6J67_RS11725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J67_RS11730	COG1882	Formate acetyltransferase
A6J67_RS11735	COG2116	formate transmembrane transporter activity
A6J67_RS11740	COG1944	ATP diphosphatase activity
A6J67_RS11745	COG0252	asparaginase activity
A6J67_RS11755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6J67_RS11770	COG0539	negative regulation of cytoplasmic translation
A6J67_RS11775	COG0776	regulation of translation
A6J67_RS11780	COG2333	competence protein COMEC
A6J67_RS11780	COG0658	competence protein
A6J67_RS11790	COG1663	tetraacyldisaccharide 4'-kinase activity
A6J67_RS11805	COG1278	Cold shock
A6J67_RS11810	COG2835	tetraacyldisaccharide 4'-kinase activity
A6J67_RS11820	COG3173	Aminoglycoside phosphotransferase
A6J67_RS11825	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6J67_RS11830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6J67_RS11845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6J67_RS11850	COG2989	Protein conserved in bacteria
A6J67_RS11855	COG3108	Peptidase M15
A6J67_RS11860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J67_RS11865	COG2200	EAL domain
A6J67_RS11870	COG1448	Aminotransferase
A6J67_RS11880	COG0017	Asparaginyl-tRNA synthetase
A6J67_RS11885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J67_RS11895	COG0308	aminopeptidase N
A6J67_RS11915	COG3217	Mosc domain protein beta barrel domain protein
A6J67_RS11915	COG0633	Ferredoxin
A6J67_RS11920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J67_RS11920	COG0116	Belongs to the methyltransferase superfamily
A6J67_RS11925	COG0488	(ABC) transporter
A6J67_RS11930	COG2995	paraquat-inducible protein a
A6J67_RS11935	COG3008	intermembrane lipid transfer
A6J67_RS11935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J67_RS11940	COG3009	Protein conserved in bacteria
A6J67_RS11945	COG3130	regulation of translation
A6J67_RS11960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J67_RS11965	COG1067	ATP-dependent peptidase activity
A6J67_RS11970	COG3120	sequence-specific DNA binding
A6J67_RS11980	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
A6J67_RS11985	COG3070	regulator of competence-specific genes
A6J67_RS11990	COG1289	transmembrane transporter activity
A6J67_RS11995	COG3304	Inner membrane component domain
A6J67_RS12000	COG0210	DNA helicase
A6J67_RS12015	COG1832	CoA-binding protein
A6J67_RS12020	COG3785	DNA binding
A6J67_RS12030	COG1254	Belongs to the acylphosphatase family
A6J67_RS12035	COG2920	part of a sulfur-relay system
A6J67_RS12060	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A6J67_RS12065	COG3121	Chaperone
A6J67_RS12080	COG3121	Chaperone
A6J67_RS12115	COG0058	SHG alpha-glucan phosphorylase activity
A6J67_RS12125	COG0745	RESPONSE REGULATOR receiver
A6J67_RS12130	COG1366	Belongs to the anti-sigma-factor antagonist family
A6J67_RS12135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6J67_RS12145	COG1215	transferase activity, transferring glycosyl groups
A6J67_RS12165	COG3250	beta-galactosidase activity
A6J67_RS12170	COG4999	Histidine kinase
A6J67_RS12170	COG3850	Histidine kinase
A6J67_RS12170	COG3437	response regulator, receiver
A6J67_RS12170	COG2205	protein histidine kinase activity
A6J67_RS12180	COG0583	DNA-binding transcription factor activity
A6J67_RS12200	COG3622	Belongs to the hyi family
A6J67_RS12205	COG2084	Dehydrogenase
A6J67_RS12210	COG1953	Uracil, thiamine, allantoin
A6J67_RS12220	COG2233	PERMEase
A6J67_RS12225	COG1929	Belongs to the glycerate kinase type-1 family
A6J67_RS12230	COG3257	ureidoglycine aminohydrolase activity
A6J67_RS12235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J67_RS12240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6J67_RS12245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6J67_RS12260	COG0549	Belongs to the carbamate kinase family
A6J67_RS12280	COG1470	cell adhesion involved in biofilm formation
A6J67_RS12280	COG1388	LysM domain
A6J67_RS12300	COG0076	glutamate decarboxylase activity
A6J67_RS12305	COG0531	amino acid
A6J67_RS12315	COG2771	luxR family
A6J67_RS12320	COG3916	Acyl-homoserine-lactone synthase
A6J67_RS12350	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A6J67_RS12355	COG2943	transferase activity, transferring hexosyl groups
A6J67_RS12360	COG5645	(Lipo)protein
A6J67_RS12380	COG2814	Major facilitator Superfamily
A6J67_RS12385	COG2259	Doxx family
A6J67_RS12390	COG1560	Kdo2-lipid A biosynthetic process
A6J67_RS12430	COG0628	permease
A6J67_RS12460	COG0418	dihydroorotase activity
A6J67_RS12465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A6J67_RS12470	COG1530	ribonuclease E activity
A6J67_RS12475	COG0564	pseudouridine synthase activity
A6J67_RS12485	COG1399	metal-binding, possibly nucleic acid-binding protein
A6J67_RS12490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J67_RS12495	COG0416	fatty acid biosynthetic process
A6J67_RS12505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J67_RS12520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J67_RS12525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J67_RS12530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J67_RS12535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6J67_RS12540	COG0470	DNA polymerase III
A6J67_RS12545	COG0084	hydrolase, TatD family'
A6J67_RS12550	COG1263	PTS System
A6J67_RS12550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS12560	COG0537	adenosine 5'-monophosphoramidase activity
A6J67_RS12565	COG5633	Lipoprotein
A6J67_RS12570	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A6J67_RS12585	COG3150	esterase
A6J67_RS12590	COG1252	NADH dehydrogenase
A6J67_RS12595	COG3134	Outer membrane lipoprotein
A6J67_RS12600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J67_RS12610	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J67_RS12620	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6J67_RS12625	COG1940	carbohydrate kinase activity
A6J67_RS12640	COG2850	peptidyl-arginine hydroxylation
A6J67_RS12650	COG0745	RESPONSE REGULATOR receiver
A6J67_RS12660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J67_RS12665	COG2915	High frequency lysogenization protein hflD homolog
A6J67_RS12670	COG0482	sulfurtransferase activity
A6J67_RS12685	COG0538	isocitrate dehydrogenase activity
A6J67_RS12705	COG3397	chitin binding
A6J67_RS12715	COG0840	transmembrane signaling receptor activity
A6J67_RS12725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J67_RS12735	COG2873	o-acetylhomoserine
A6J67_RS12740	COG0702	epimerase
A6J67_RS12745	COG1733	regulation of RNA biosynthetic process
A6J67_RS12755	COG0697	spore germination
A6J67_RS12765	COG3755	Protein conserved in bacteria
A6J67_RS12780	COG2203	Gaf domain
A6J67_RS12780	COG4251	negative regulation of phosphorylation
A6J67_RS12780	COG3706	GGDEF domain
A6J67_RS12780	COG5001	Diguanylate cyclase
A6J67_RS12790	COG1132	(ABC) transporter
A6J67_RS12810	COG2207	Transcriptional regulator
A6J67_RS12840	COG1113	amino acid transport
A6J67_RS12860	COG1496	oxidoreductase activity
A6J67_RS12865	COG0768	penicillin binding
A6J67_RS12870	COG2226	methyltransferase
A6J67_RS12880	COG3447	MASE1 domain protein
A6J67_RS12880	COG5002	protein histidine kinase activity
A6J67_RS12880	COG5001	Diguanylate cyclase
A6J67_RS12895	COG1971	Probably functions as a manganese efflux pump
A6J67_RS12900	COG4811	Protein of unknown function (DUF986)
A6J67_RS12905	COG3716	PTS system mannose fructose sorbose family IID component
A6J67_RS12910	COG3715	PTS system
A6J67_RS12915	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS12915	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J67_RS12920	COG1253	flavin adenine dinucleotide binding
A6J67_RS12930	COG1760	l-serine dehydratase
A6J67_RS12935	COG0494	nUDIX hydrolase
A6J67_RS12945	COG3140	Belongs to the UPF0181 family
A6J67_RS12950	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6J67_RS12955	COG0513	Belongs to the DEAD box helicase family
A6J67_RS12960	COG3141	response to X-ray
A6J67_RS12965	COG3097	Belongs to the UPF0267 family
A6J67_RS12975	COG1770	oligopeptidase
A6J67_RS12980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J67_RS12995	COG1528	Iron-storage protein
A6J67_RS13000	COG2372	response to copper ion
A6J67_RS13005	COG1276	copper resistance
A6J67_RS13015	COG0582	viral genome integration into host DNA
A6J67_RS13060	COG1396	sequence-specific DNA binding
A6J67_RS13130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6J67_RS13390	COG0668	transmembrane transport
A6J67_RS13395	COG1187	pseudouridine synthase activity
A6J67_RS13405	COG0697	spore germination
A6J67_RS13425	COG0625	glutathione transferase activity
A6J67_RS13455	COG2203	Gaf domain
A6J67_RS13455	COG3706	GGDEF domain
A6J67_RS13455	COG4251	negative regulation of phosphorylation
A6J67_RS13455	COG5001	Diguanylate cyclase
A6J67_RS13460	COG2814	Major facilitator Superfamily
A6J67_RS13470	COG3008	intermembrane lipid transfer
A6J67_RS13475	COG2995	paraquat-inducible protein a
A6J67_RS13480	COG1956	GAF domain-containing protein
A6J67_RS13490	COG0793	Belongs to the peptidase S41A family
A6J67_RS13495	COG0501	Belongs to the peptidase M48B family
A6J67_RS13500	COG2814	Major facilitator Superfamily
A6J67_RS13505	COG0823	Involved in the tonB-independent uptake of proteins
A6J67_RS13515	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6J67_RS13520	COG1823	symporter activity
A6J67_RS13525	COG1988	membrane-bound metal-dependent
A6J67_RS13530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6J67_RS13545	COG3842	ATPase activity
A6J67_RS13550	COG0395	ABC-type sugar transport system, permease component
A6J67_RS13555	COG1175	transmembrane transport
A6J67_RS13565	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS13575	COG1917	Cupin 2, conserved barrel domain protein
A6J67_RS13580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J67_RS13590	COG0583	DNA-binding transcription factor activity
A6J67_RS13595	COG0427	acetyl-CoA hydrolase
A6J67_RS13600	COG1024	Enoyl-CoA hydratase
A6J67_RS13605	COG1703	isobutyryl-CoA mutase activity
A6J67_RS13610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J67_RS13610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A6J67_RS13615	COG3001	Fructosamine kinase
A6J67_RS13620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J67_RS13625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J67_RS13630	COG1121	(ABC) transporter
A6J67_RS13670	COG3623	hexulose-6-phosphate isomerase
A6J67_RS13675	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6J67_RS13680	COG1070	Carbohydrate kinase
A6J67_RS13700	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS13705	COG1129	ABC transporter
A6J67_RS13710	COG1414	Transcriptional regulator
A6J67_RS13720	COG4249	Peptidase C14 caspase catalytic subunit p20
A6J67_RS13730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J67_RS13735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J67_RS13755	COG0776	regulation of translation
A6J67_RS13765	COG4139	cobalamin transport
A6J67_RS13770	COG0386	Belongs to the glutathione peroxidase family
A6J67_RS13780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J67_RS13785	COG0463	Glycosyl transferase, family 2
A6J67_RS13795	COG0726	polysaccharide deacetylase
A6J67_RS13800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A6J67_RS13805	COG2076	Multidrug Resistance protein
A6J67_RS13810	COG2076	Multidrug Resistance protein
A6J67_RS13815	COG0791	NLP P60 protein
A6J67_RS13820	COG0095	Lipoate-protein ligase
A6J67_RS13830	COG4558	Periplasmic binding protein
A6J67_RS13835	COG3720	iron ion transport
A6J67_RS13850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J67_RS13855	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6J67_RS13865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J67_RS13865	COG0574	Belongs to the PEP-utilizing enzyme family
A6J67_RS13875	COG0628	permease
A6J67_RS13880	COG0247	lactate metabolic process
A6J67_RS13880	COG0277	FAD linked oxidase domain protein
A6J67_RS13885	COG2050	protein possibly involved in aromatic compounds catabolism
A6J67_RS13895	COG0316	Belongs to the HesB IscA family
A6J67_RS13900	COG0719	Fe-S assembly protein
A6J67_RS13905	COG0396	ATPase activity
A6J67_RS13910	COG0719	Fe-S assembly protein
A6J67_RS13920	COG2166	iron-sulfur cluster assembly
A6J67_RS13925	COG1388	LysM domain
A6J67_RS13925	COG1376	ErfK ybiS ycfS ynhG family protein
A6J67_RS13955	COG0534	Mate efflux family protein
A6J67_RS13960	COG0307	riboflavin synthase, alpha
A6J67_RS13965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J67_RS13970	COG2814	Major facilitator Superfamily
A6J67_RS13975	COG0583	DNA-binding transcription factor activity
A6J67_RS13980	COG1609	Transcriptional regulator
A6J67_RS13990	COG0791	NLP P60 protein
A6J67_RS13995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6J67_RS14000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J67_RS14005	COG0346	lactoylglutathione lyase activity
A6J67_RS14010	COG1902	pentaerythritol trinitrate reductase activity
A6J67_RS14015	COG1309	transcriptional regulator
A6J67_RS14020	COG2194	sulfuric ester hydrolase activity
A6J67_RS14025	COG3313	Fe-S protein
A6J67_RS14030	COG4989	oxidoreductase activity
A6J67_RS14035	COG1289	transmembrane transporter activity
A6J67_RS14040	COG1566	PFAM secretion protein HlyD family protein
A6J67_RS14055	COG3133	Outer membrane lipoprotein
A6J67_RS14060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6J67_RS14065	COG3895	Periplasmic Protein
A6J67_RS14075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J67_RS14085	COG0625	glutathione transferase activity
A6J67_RS14105	COG3104	oligopeptide transport
A6J67_RS14115	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J67_RS14115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6J67_RS14125	COG4172	Belongs to the ABC transporter superfamily
A6J67_RS14135	COG4171	peptide transport system, permease
A6J67_RS14140	COG4168	peptide transport system, permease
A6J67_RS14145	COG4166	transmembrane transport
A6J67_RS14165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6J67_RS14170	COG1842	Phage shock protein A
A6J67_RS14180	COG1983	PspC domain protein
A6J67_RS14190	COG3106	COG3106 Predicted ATPase
A6J67_RS14195	COG3768	UPF0283 membrane protein
A6J67_RS14200	COG5654	RES domain protein
A6J67_RS14205	COG5642	Protein of unknown function (DUF2384)
A6J67_RS14215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6J67_RS14220	COG4948	Mandelate Racemase Muconate Lactonizing
A6J67_RS14225	COG2866	Carboxypeptidase
A6J67_RS14230	COG4166	transmembrane transport
A6J67_RS14235	COG0598	Magnesium transport protein CorA
A6J67_RS14240	COG0037	tRNA processing
A6J67_RS14245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6J67_RS14245	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6J67_RS14245	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6J67_RS14245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J67_RS14255	COG1285	pathogenesis
A6J67_RS14260	COG3042	response to heat
A6J67_RS14265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J67_RS14270	COG2911	Protein conserved in bacteria
A6J67_RS14280	COG3784	Protein of unknown function (DUF1318)
A6J67_RS14285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6J67_RS14290	COG1643	Atp-dependent helicase
A6J67_RS14305	COG3591	Belongs to the peptidase S1B family
A6J67_RS14315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6J67_RS14320	COG2205	protein histidine kinase activity
A6J67_RS14325	COG0745	RESPONSE REGULATOR receiver
A6J67_RS14335	COG0531	amino acid
A6J67_RS14345	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6J67_RS14350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6J67_RS14355	COG0589	response to stress
A6J67_RS14360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6J67_RS14365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J67_RS14380	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A6J67_RS14390	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS14400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J67_RS14405	COG0738	Major facilitator superfamily
A6J67_RS14420	COG0583	DNA-binding transcription factor activity
A6J67_RS14430	COG1011	Hydrolase
A6J67_RS14435	COG0251	oxidation-reduction process
A6J67_RS14440	COG0440	acetolactate synthase activity
A6J67_RS14445	COG0028	Belongs to the TPP enzyme family
A6J67_RS14475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J67_RS14485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J67_RS14490	COG1477	protein flavinylation
A6J67_RS14505	COG4215	(ABC) transporter
A6J67_RS14515	COG1522	sequence-specific DNA binding
A6J67_RS14525	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J67_RS14530	COG1773	rubredoxin
A6J67_RS14530	COG0426	domain, Protein
A6J67_RS14535	COG3604	Transcriptional regulator
A6J67_RS14540	COG0625	glutathione transferase activity
A6J67_RS14565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J67_RS14570	COG1393	Belongs to the ArsC family
A6J67_RS14590	COG1649	PFAM Uncharacterised BCR, COG1649
A6J67_RS14595	COG0110	maltose O-acetyltransferase activity
A6J67_RS14600	COG4221	oxidoreductase activity
A6J67_RS14610	COG1742	UPF0060 membrane protein
A6J67_RS14630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6J67_RS14635	COG1940	carbohydrate kinase activity
A6J67_RS14640	COG0583	DNA-binding transcription factor activity
A6J67_RS14645	COG2814	Major facilitator Superfamily
A6J67_RS14665	COG0114	fumarate hydratase activity
A6J67_RS14675	COG5339	Protein conserved in bacteria
A6J67_RS14685	COG1609	Transcriptional regulator
A6J67_RS14690	COG1263	PTS System
A6J67_RS14690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS14695	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J67_RS14700	COG2188	Transcriptional regulator
A6J67_RS14705	COG4948	Mandelate Racemase Muconate Lactonizing
A6J67_RS14710	COG2190	(PTS) system
A6J67_RS14710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS14710	COG1263	PTS System
A6J67_RS14715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6J67_RS14720	COG0385	Bile acid
A6J67_RS14725	COG0673	inositol 2-dehydrogenase activity
A6J67_RS14735	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS14740	COG1129	ABC transporter
A6J67_RS14745	COG1879	ABC-type sugar transport system periplasmic component
A6J67_RS14760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J67_RS14765	COG2723	6-phospho-beta-galactosidase activity
A6J67_RS14770	COG2274	protein secretion by the type I secretion system
A6J67_RS14775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS14780	COG2274	protein secretion by the type I secretion system
A6J67_RS14785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J67_RS14795	COG4657	Part of a membrane complex involved in electron transport
A6J67_RS14805	COG4656	Part of a membrane complex involved in electron transport
A6J67_RS14810	COG2207	Transcriptional regulator
A6J67_RS14810	COG3708	Transcriptional regulator
A6J67_RS14815	COG4658	electron transport chain
A6J67_RS14820	COG4659	FMN binding
A6J67_RS14830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J67_RS14835	COG0243	molybdopterin cofactor binding
A6J67_RS14840	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A6J67_RS14850	COG2879	small protein
A6J67_RS14855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J67_RS14860	COG1349	DNA-binding transcription factor activity
A6J67_RS14870	COG0235	Class ii aldolase
A6J67_RS14880	COG0023	Translation Initiation Factor
A6J67_RS14900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6J67_RS14905	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6J67_RS14910	COG0671	phosphoesterase, PA-phosphatase related
A6J67_RS14920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6J67_RS14930	COG0583	DNA-binding transcription factor activity
A6J67_RS14945	COG0616	signal peptide processing
A6J67_RS14965	COG1187	pseudouridine synthase activity
A6J67_RS14975	COG0009	L-threonylcarbamoyladenylate synthase
A6J67_RS14980	COG0613	PHP domain protein
A6J67_RS14990	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J67_RS15000	COG0135	phosphoribosylanthranilate isomerase activity
A6J67_RS15000	COG0134	indole-3-glycerol-phosphate synthase activity
A6J67_RS15005	COG0133	tryptophan synthase activity
A6J67_RS15010	COG0159	tryptophan synthase activity
A6J67_RS15020	COG3047	cAMP biosynthetic process
A6J67_RS15025	COG0727	PFAM Uncharacterised protein family (UPF0153)
A6J67_RS15040	COG2917	probably involved in intracellular septation
A6J67_RS15050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6J67_RS15055	COG2350	Protein conserved in bacteria
A6J67_RS15080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J67_RS15085	COG3099	Belongs to the UPF0263 family
A6J67_RS15095	COG0444	Belongs to the ABC transporter superfamily
A6J67_RS15100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J67_RS15115	COG4166	transmembrane transport
A6J67_RS15120	COG2095	MarC family integral membrane protein
A6J67_RS15135	COG1454	alcohol dehydrogenase
A6J67_RS15135	COG1012	belongs to the aldehyde dehydrogenase family
A6J67_RS15145	COG2916	Histone family protein nucleoid-structuring protein H-NS
A6J67_RS15155	COG0745	RESPONSE REGULATOR receiver
A6J67_RS15160	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6J67_RS15170	COG3012	SEC-C Motif Domain Protein
A6J67_RS15175	COG0788	formyltetrahydrofolate deformylase activity
A6J67_RS15215	COG0708	Exodeoxyribonuclease III
A6J67_RS15220	COG0494	nUDIX hydrolase
A6J67_RS15230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J67_RS15240	COG0778	Nitroreductase
A6J67_RS15245	COG0616	signal peptide processing
A6J67_RS15250	COG0252	asparaginase activity
A6J67_RS15255	COG1335	isochorismatase
A6J67_RS15260	COG3139	Protein of unknown function (DUF1315)
A6J67_RS15280	COG3713	MltA-interacting MipA family protein
A6J67_RS15290	COG2766	serine protein kinase
A6J67_RS15295	COG2718	Belongs to the UPF0229 family
A6J67_RS15305	COG2199	diguanylate cyclase activity
A6J67_RS15305	COG2200	EAL domain
A6J67_RS15305	COG2202	Pas domain
A6J67_RS15310	COG2814	Major facilitator Superfamily
A6J67_RS15315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J67_RS15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J67_RS15325	COG2719	SpoVR family
A6J67_RS15330	COG2186	Transcriptional regulator
A6J67_RS15340	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J67_RS15345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6J67_RS15350	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J67_RS15360	COG2983	Belongs to the UPF0260 family
A6J67_RS15365	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J67_RS15370	COG2951	lytic endotransglycosylase activity
A6J67_RS15375	COG3100	YcgL domain-containing protein
A6J67_RS15385	COG0850	regulation of cytokinetic process
A6J67_RS15390	COG2894	cell division
A6J67_RS15395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6J67_RS15400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6J67_RS15405	COG0318	PFAM AMP-dependent synthetase and ligase
A6J67_RS15410	COG3065	identical protein binding
A6J67_RS15420	COG1199	ATP-dependent helicase activity
A6J67_RS15425	COG0251	oxidation-reduction process
A6J67_RS15430	COG2076	Multidrug Resistance protein
A6J67_RS15435	COG2076	Multidrug Resistance protein
A6J67_RS15440	COG0800	Aldolase
A6J67_RS15445	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J67_RS15450	COG1737	Transcriptional regulator
A6J67_RS15455	COG0469	pyruvate kinase activity
A6J67_RS15460	COG1560	Kdo2-lipid A biosynthetic process
A6J67_RS15465	COG0739	heme binding
A6J67_RS15470	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6J67_RS15475	COG1121	(ABC) transporter
A6J67_RS15480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J67_RS15495	COG0632	four-way junction helicase activity
A6J67_RS15505	COG0217	transcriptional regulatory protein
A6J67_RS15510	COG0494	nUDIX hydrolase
A6J67_RS15515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J67_RS15520	COG1335	isochorismatase
A6J67_RS15525	COG1801	Protein of unknown function DUF72
A6J67_RS15530	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A6J67_RS15535	COG2226	methyltransferase
A6J67_RS15545	COG3142	Participates in the control of copper homeostasis
A6J67_RS15550	COG3102	Protein conserved in bacteria
A6J67_RS15595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J67_RS15600	COG0477	Major facilitator Superfamily
A6J67_RS15610	COG3381	protein complex oligomerization
A6J67_RS15620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J67_RS15640	COG3706	GGDEF domain
A6J67_RS15645	COG0659	secondary active sulfate transmembrane transporter activity
A6J67_RS15665	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J67_RS15670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J67_RS15675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6J67_RS15680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6J67_RS15690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J67_RS15700	COG0193	aminoacyl-tRNA hydrolase activity
A6J67_RS15710	COG0012	GTP binding
A6J67_RS15720	COG4942	peptidase
A6J67_RS15730	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6J67_RS15735	COG4211	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS15740	COG1129	ABC transporter
A6J67_RS15755	COG0402	S-adenosylhomocysteine deaminase activity
A6J67_RS15765	COG1228	amidohydrolase
A6J67_RS15785	COG3724	N-succinylarginine dihydrolase activity
A6J67_RS15795	COG3138	arginine N-succinyltransferase
A6J67_RS15805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J67_RS15810	COG1271	oxidase subunit
A6J67_RS15825	COG3850	Histidine kinase
A6J67_RS15830	COG0583	DNA-binding transcription factor activity
A6J67_RS15835	COG2814	Major facilitator Superfamily
A6J67_RS15845	COG0387	Pfam Sodium calcium exchanger
A6J67_RS15850	COG1702	phosphate starvation-inducible protein PhoH
A6J67_RS15865	COG3658	cytochrome
A6J67_RS15870	COG1215	transferase activity, transferring glycosyl groups
A6J67_RS15875	COG0726	polysaccharide deacetylase
A6J67_RS15875	COG1649	PFAM Uncharacterised BCR, COG1649
A6J67_RS15880	COG0457	Tetratricopeptide repeat
A6J67_RS15885	COG0006	proline dipeptidase activity
A6J67_RS15890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J67_RS15915	COG0577	efflux transmembrane transporter activity
A6J67_RS15915	COG1136	(ABC) transporter
A6J67_RS15925	COG0577	efflux transmembrane transporter activity
A6J67_RS15925	COG1136	(ABC) transporter
A6J67_RS15940	COG0672	)-iron permease
A6J67_RS15950	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J67_RS15955	COG2723	6-phospho-beta-galactosidase activity
A6J67_RS15960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J67_RS15965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J67_RS15970	COG1609	Transcriptional regulator
A6J67_RS15980	COG3622	Belongs to the hyi family
A6J67_RS15985	COG0235	Class ii aldolase
A6J67_RS15990	COG3395	kinase activity
A6J67_RS15995	COG2084	Dehydrogenase
A6J67_RS16000	COG1349	DNA-binding transcription factor activity
A6J67_RS16005	COG3290	protein histidine kinase activity
A6J67_RS16010	COG4565	transcriptional regulatory protein
A6J67_RS16015	COG3493	citrate carrier protein
A6J67_RS16025	COG2181	nitrate reductase activity
A6J67_RS16030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A6J67_RS16035	COG1140	nitrate reductase beta subunit
A6J67_RS16040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A6J67_RS16045	COG2223	nitrite transmembrane transporter activity
A6J67_RS16050	COG2197	response regulator
A6J67_RS16070	COG2223	nitrite transmembrane transporter activity
A6J67_RS16075	COG0561	phosphatase activity
A6J67_RS16080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J67_RS16095	COG2197	response regulator
A6J67_RS16115	COG3121	Chaperone
A6J67_RS16235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J67_RS16240	COG0322	excinuclease ABC activity
A6J67_RS16245	COG2197	response regulator
A6J67_RS16255	COG3136	membrane protein required for alginate biosynthesis
A6J67_RS16265	COG0840	transmembrane signaling receptor activity
A6J67_RS16270	COG0366	Alpha amylase catalytic
A6J67_RS16290	COG2203	Gaf domain
A6J67_RS16290	COG2199	diguanylate cyclase activity
A6J67_RS16295	COG0582	viral genome integration into host DNA
A6J67_RS16320	COG4974	Belongs to the 'phage' integrase family
A6J67_RS16390	COG4695	Portal protein
A6J67_RS16485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6J67_RS16535	COG1113	amino acid transport
A6J67_RS16545	COG1881	PFAM PEBP family protein
A6J67_RS16565	COG2822	iron ion transport
A6J67_RS16570	COG0672	)-iron permease
A6J67_RS16575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J67_RS16580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6J67_RS16580	COG0506	proline dehydrogenase activity
A6J67_RS16580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A6J67_RS16595	COG1126	abc transporter atp-binding protein
A6J67_RS16600	COG0765	amino acid transport
A6J67_RS16605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS16610	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A6J67_RS16620	COG1191	sigma factor activity
A6J67_RS16650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6J67_RS16655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6J67_RS16660	COG1677	Flagellar hook-basal body complex protein FliE
A6J67_RS16675	COG1317	bacterial-type flagellum organization
A6J67_RS16730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J67_RS16735	COG1256	bacterial-type flagellum assembly
A6J67_RS16770	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6J67_RS16775	COG1558	bacterial-type flagellum-dependent cell motility
A6J67_RS16780	COG1815	bacterial-type flagellum-dependent cell motility
A6J67_RS16790	COG2747	anti-sigma28 factor FlgM
A6J67_RS16795	COG3418	PFAM FlgN family protein
A6J67_RS16805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J67_RS16810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J67_RS16815	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6J67_RS16820	COG0745	RESPONSE REGULATOR receiver
A6J67_RS16830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J67_RS16845	COG0840	transmembrane signaling receptor activity
A6J67_RS16850	COG0835	chemotaxis
A6J67_RS16855	COG0643	Histidine kinase
A6J67_RS16855	COG2198	Histidine kinase
A6J67_RS16880	COG0589	response to stress
A6J67_RS16885	COG2130	NADP-dependent
A6J67_RS16895	COG1285	pathogenesis
A6J67_RS16900	COG0840	transmembrane signaling receptor activity
A6J67_RS16915	COG1609	Transcriptional regulator
A6J67_RS16920	COG3250	beta-galactosidase activity
A6J67_RS16930	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS16930	COG0604	alcohol dehydrogenase
A6J67_RS16930	COG3321	synthase
A6J67_RS16960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J67_RS16965	COG3121	Chaperone
A6J67_RS16980	COG3121	Chaperone
A6J67_RS17000	COG3228	Belongs to the MtfA family
A6J67_RS17015	COG0251	oxidation-reduction process
A6J67_RS17050	COG2204	response regulator
A6J67_RS17065	COG2211	Major facilitator Superfamily
A6J67_RS17075	COG2814	Major facilitator Superfamily
A6J67_RS17085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6J67_RS17100	COG0471	metal ion transport
A6J67_RS17115	COG3051	citrate lyase alpha subunit
A6J67_RS17125	COG3052	prosthetic group binding
A6J67_RS17135	COG3290	protein histidine kinase activity
A6J67_RS17140	COG4565	transcriptional regulatory protein
A6J67_RS17155	COG2271	Major facilitator Superfamily
A6J67_RS17160	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J67_RS17170	COG3842	ATPase activity
A6J67_RS17185	COG2205	protein histidine kinase activity
A6J67_RS17185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS17215	COG3121	Chaperone
A6J67_RS17380	COG0583	DNA-binding transcription factor activity
A6J67_RS17390	COG1349	DNA-binding transcription factor activity
A6J67_RS17395	COG0561	phosphatase activity
A6J67_RS17415	COG0835	chemotaxis
A6J67_RS17415	COG0784	Response regulator, receiver
A6J67_RS17420	COG0534	Mate efflux family protein
A6J67_RS17425	COG0137	argininosuccinate synthase activity
A6J67_RS17430	COG2211	Major facilitator Superfamily
A6J67_RS17435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6J67_RS17445	COG0583	DNA-binding transcription factor activity
A6J67_RS17470	COG1492	cobalamin metabolic process
A6J67_RS17535	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A6J67_RS17545	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A6J67_RS17605	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A6J67_RS17620	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A6J67_RS17625	COG2096	Adenosyltransferase
A6J67_RS17640	COG4656	Part of a membrane complex involved in electron transport
A6J67_RS17670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J67_RS17685	COG1129	ABC transporter
A6J67_RS17690	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS17715	COG2925	Exonuclease
A6J67_RS17720	COG0531	amino acid
A6J67_RS17730	COG0371	Dehydrogenase
A6J67_RS17735	COG1129	ABC transporter
A6J67_RS17740	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS17745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J67_RS17750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6J67_RS17760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J67_RS17765	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J67_RS17765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J67_RS17780	COG0107	imidazoleglycerol-phosphate synthase activity
A6J67_RS17785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J67_RS17785	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J67_RS17790	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J67_RS17795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J67_RS17800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J67_RS17805	COG1253	flavin adenine dinucleotide binding
A6J67_RS17810	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J67_RS17815	COG2982	Protein involved in outer membrane biogenesis
A6J67_RS17825	COG0572	uridine kinase
A6J67_RS17830	COG0489	protein tyrosine kinase activity
A6J67_RS17835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J67_RS17835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J67_RS17855	COG2814	Major facilitator Superfamily
A6J67_RS17860	COG1380	Effector of murein hydrolase LrgA
A6J67_RS17865	COG1346	cytolysis
A6J67_RS17875	COG0281	malic enzyme
A6J67_RS17880	COG2949	membrane
A6J67_RS17890	COG0298	carbon dioxide binding
A6J67_RS17895	COG0375	protein maturation
A6J67_RS17900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS17905	COG0651	ATP synthesis coupled electron transport
A6J67_RS17910	COG0650	Formate hydrogenlyase subunit 4
A6J67_RS17915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J67_RS17920	COG4237	Hydrogenase 4 membrane
A6J67_RS17925	COG0651	ATP synthesis coupled electron transport
A6J67_RS17930	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A6J67_RS17930	COG3261	NADH dehydrogenase
A6J67_RS17935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J67_RS17940	COG3260	NADH ubiquinone oxidoreductase 20
A6J67_RS17950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A6J67_RS17955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J67_RS17960	COG3383	formate dehydrogenase (NAD+) activity
A6J67_RS17965	COG3604	Transcriptional regulator
A6J67_RS17970	COG2116	formate transmembrane transporter activity
A6J67_RS17990	COG1609	Transcriptional regulator
A6J67_RS17995	COG2311	Membrane
A6J67_RS18000	COG0302	gtp cyclohydrolase
A6J67_RS18005	COG0477	Major facilitator Superfamily
A6J67_RS18010	COG0583	DNA-binding transcription factor activity
A6J67_RS18040	COG1136	(ABC) transporter
A6J67_RS18050	COG0477	Major facilitator Superfamily
A6J67_RS18060	COG0303	'Molybdopterin
A6J67_RS18070	COG0488	(ABC) transporter
A6J67_RS18090	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6J67_RS18105	COG4106	trans-aconitate 2-methyltransferase activity
A6J67_RS18115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J67_RS18120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS18125	COG0765	amino acid transport
A6J67_RS18130	COG1126	abc transporter atp-binding protein
A6J67_RS18135	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6J67_RS18140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J67_RS18145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J67_RS18165	COG0697	spore germination
A6J67_RS18175	COG0583	DNA-binding transcription factor activity
A6J67_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS18190	COG1174	glycine betaine transport
A6J67_RS18195	COG1125	glycine betaine transport
A6J67_RS18200	COG1174	glycine betaine transport
A6J67_RS18205	COG1732	Glycine betaine
A6J67_RS18215	COG0673	inositol 2-dehydrogenase activity
A6J67_RS18220	COG2897	thiosulfate sulfurtransferase activity
A6J67_RS18250	COG4807	Protein conserved in bacteria
A6J67_RS18265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A6J67_RS18295	COG0277	FAD linked oxidase domain protein
A6J67_RS18300	COG1686	Belongs to the peptidase S11 family
A6J67_RS18310	COG2239	Acts as a magnesium transporter
A6J67_RS18315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J67_RS18320	COG0513	Belongs to the DEAD box helicase family
A6J67_RS18325	COG1309	transcriptional regulator
A6J67_RS18330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS18335	COG1131	(ABC) transporter
A6J67_RS18340	COG0842	Transport permease protein
A6J67_RS18345	COG0842	Transport permease protein
A6J67_RS18350	COG0670	Belongs to the BI1 family
A6J67_RS18355	COG0314	molybdopterin synthase activity
A6J67_RS18360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6J67_RS18365	COG0315	cyclic pyranopterin monophosphate synthase activity
A6J67_RS18370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J67_RS18375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6J67_RS18380	COG4628	conserved protein (DUF2132)
A6J67_RS18385	COG0556	nucleotide-excision repair
A6J67_RS18400	COG2226	methyltransferase
A6J67_RS18410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J67_RS18420	COG2706	6-phosphogluconolactonase activity
A6J67_RS18425	COG0561	phosphatase activity
A6J67_RS18435	COG4149	molybdate abc transporter
A6J67_RS18440	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6J67_RS18450	COG3585	molybdate ion transport
A6J67_RS18450	COG2005	Transcriptional regulator
A6J67_RS18455	COG1119	ATPase activity
A6J67_RS18465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J67_RS18475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6J67_RS18480	COG2017	converts alpha-aldose to the beta-anomer
A6J67_RS18490	COG0588	phosphoglycerate mutase activity
A6J67_RS18495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J67_RS18500	COG2197	response regulator
A6J67_RS18505	COG2205	protein histidine kinase activity
A6J67_RS18505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS18510	COG1230	cation diffusion facilitator family transporter
A6J67_RS18520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6J67_RS18550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6J67_RS18555	COG2885	chlorophyll binding
A6J67_RS18560	COG0823	Involved in the tonB-independent uptake of proteins
A6J67_RS18565	COG3064	Membrane
A6J67_RS18565	COG3064	Membrane
A6J67_RS18570	COG0848	biopolymer transport protein
A6J67_RS18575	COG0811	peptide transport
A6J67_RS18580	COG0824	Thioesterase
A6J67_RS18585	COG3790	cyd operon protein YbgE
A6J67_RS18590	COG4890	Cyd operon protein YbgT
A6J67_RS18595	COG1294	oxidase, subunit
A6J67_RS18600	COG1271	oxidase subunit
A6J67_RS18605	COG0737	Belongs to the 5'-nucleotidase family
A6J67_RS18610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6J67_RS18615	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J67_RS18620	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J67_RS18625	COG0567	Dehydrogenase, E1 component
A6J67_RS18635	COG1053	succinate dehydrogenase
A6J67_RS18640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6J67_RS18645	COG2009	succinate dehydrogenase
A6J67_RS18670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6J67_RS18675	COG1984	allophanate hydrolase subunit 2
A6J67_RS18680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6J67_RS18685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J67_RS18690	COG5212	phosphodiesterase
A6J67_RS18700	COG3272	Protein of unknown function (DUF1722)
A6J67_RS18720	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A6J67_RS18725	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6J67_RS18735	COG0745	RESPONSE REGULATOR receiver
A6J67_RS18745	COG0033	Phosphoglucomutase
A6J67_RS18750	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6J67_RS18775	COG3210	domain, Protein
A6J67_RS18820	COG3210	domain, Protein
A6J67_RS18825	COG3210	domain, Protein
A6J67_RS18830	COG2831	hemolysin activation secretion protein
A6J67_RS18835	COG0596	Alpha beta hydrolase
A6J67_RS18850	COG0840	transmembrane signaling receptor activity
A6J67_RS18860	COG0735	belongs to the Fur family
A6J67_RS18880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J67_RS18885	COG2190	(PTS) system
A6J67_RS18885	COG1263	PTS System
A6J67_RS18885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS18890	COG0363	glucosamine-6-phosphate deaminase activity
A6J67_RS18895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6J67_RS18900	COG1846	Transcriptional regulator
A6J67_RS18900	COG1940	carbohydrate kinase activity
A6J67_RS18905	COG0647	UMP catabolic process
A6J67_RS18915	COG0367	asparagine synthase
A6J67_RS18960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J67_RS18965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J67_RS18970	COG1702	phosphate starvation-inducible protein PhoH
A6J67_RS18975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J67_RS18985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6J67_RS19000	COG0765	amino acid transport
A6J67_RS19005	COG0765	amino acid transport
A6J67_RS19010	COG1126	abc transporter atp-binding protein
A6J67_RS19020	COG2888	peptidyl-tyrosine sulfation
A6J67_RS19025	COG0495	leucyl-tRNA aminoacylation
A6J67_RS19030	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6J67_RS19035	COG1466	dna polymerase III delta subunit
A6J67_RS19040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J67_RS19050	COG0799	negative regulation of ribosome biogenesis
A6J67_RS19065	COG0772	Belongs to the SEDS family
A6J67_RS19070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J67_RS19075	COG1686	Belongs to the peptidase S11 family
A6J67_RS19080	COG2921	Belongs to the UPF0250 family
A6J67_RS19085	COG0321	lipoyl(octanoyl) transferase activity
A6J67_RS19090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6J67_RS19095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J67_RS19100	COG3706	GGDEF domain
A6J67_RS19115	COG1278	Cold shock
A6J67_RS19120	COG2197	response regulator
A6J67_RS19130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J67_RS19145	COG5265	(ABC) transporter
A6J67_RS19150	COG2850	peptidyl-arginine hydroxylation
A6J67_RS19160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J67_RS19165	COG0698	ribose 5-phosphate isomerase
A6J67_RS19170	COG1737	Transcriptional regulator
A6J67_RS19175	COG1879	ABC-type sugar transport system periplasmic component
A6J67_RS19180	COG1129	ABC transporter
A6J67_RS19185	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6J67_RS19190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J67_RS19195	COG1940	carbohydrate kinase activity
A6J67_RS19210	COG2610	gluconate transmembrane transporter activity
A6J67_RS19220	COG0300	oxidoreductase activity
A6J67_RS19230	COG1902	pentaerythritol trinitrate reductase activity
A6J67_RS19265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J67_RS19275	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS19280	COG0583	DNA-binding transcription factor activity
A6J67_RS19285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6J67_RS19300	COG0583	DNA-binding transcription factor activity
A6J67_RS19355	COG3122	Protein conserved in bacteria
A6J67_RS19430	COG3240	lipase activity
A6J67_RS19435	COG2169	Transcriptional regulator
A6J67_RS19440	COG1486	melibiose metabolic process
A6J67_RS19445	COG2211	Major facilitator Superfamily
A6J67_RS19455	COG1328	CTP reductase activity
A6J67_RS19460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J67_RS19470	COG2801	Transposase and inactivated derivatives
A6J67_RS19475	COG0582	viral genome integration into host DNA
A6J67_RS19505	COG0582	viral genome integration into host DNA
A6J67_RS19535	COG5301	cellulose 1,4-beta-cellobiosidase activity
A6J67_RS19585	COG4386	tail sheath protein
A6J67_RS19760	COG0582	viral genome integration into host DNA
A6J67_RS19875	COG1783	phage Terminase large subunit
A6J67_RS19915	COG0484	heat shock protein binding
A6J67_RS20090	COG0582	viral genome integration into host DNA
A6J67_RS20100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J67_RS20105	COG2501	S4 domain
A6J67_RS20115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J67_RS20120	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J67_RS20125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J67_RS20130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J67_RS20135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A6J67_RS20140	COG4181	ATPase activity
A6J67_RS20145	COG2755	lipolytic protein G-D-S-L family
A6J67_RS20150	COG0300	oxidoreductase activity
A6J67_RS20155	COG3118	belongs to the thioredoxin family
A6J67_RS20160	COG0330	HflC and HflK could
A6J67_RS20165	COG1585	Membrane protein implicated in regulation of membrane protease activity
A6J67_RS20170	COG0789	Transcriptional regulator
A6J67_RS20175	COG2217	Heavy metal translocating P-type atpase
A6J67_RS20180	COG3735	TraB family
A6J67_RS20185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J67_RS20190	COG0737	Belongs to the 5'-nucleotidase family
A6J67_RS20195	COG2223	nitrite transmembrane transporter activity
A6J67_RS20200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J67_RS20200	COG4651	solute:proton antiporter activity
A6J67_RS20205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J67_RS20210	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A6J67_RS20220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J67_RS20230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J67_RS20235	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6J67_RS20240	COG0438	transferase activity, transferring glycosyl groups
A6J67_RS20250	COG1216	Glycosyl transferase, family 2
A6J67_RS20280	COG0028	Belongs to the TPP enzyme family
A6J67_RS20300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J67_RS20300	COG0543	2 iron, 2 sulfur cluster binding
A6J67_RS20305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6J67_RS20310	COG0563	adenylate kinase activity
A6J67_RS20315	COG0326	Molecular chaperone. Has ATPase activity
A6J67_RS20320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J67_RS20325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J67_RS20330	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J67_RS20335	COG0346	lactoylglutathione lyase activity
A6J67_RS20345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J67_RS20350	COG2832	Protein of unknown function (DUF454)
A6J67_RS20370	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6J67_RS20375	COG1309	transcriptional regulator
A6J67_RS20380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS20385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6J67_RS20390	COG0254	rRNA binding
A6J67_RS20395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J67_RS20400	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J67_RS20405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J67_RS20410	COG1121	(ABC) transporter
A6J67_RS20435	COG3695	enzyme binding
A6J67_RS20440	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A6J67_RS20445	COG1946	Acyl-CoA thioesterase
A6J67_RS20450	COG0004	ammonium transporteR
A6J67_RS20455	COG0347	Belongs to the P(II) protein family
A6J67_RS20460	COG1132	(ABC) transporter
A6J67_RS20465	COG1132	(ABC) transporter
A6J67_RS20470	COG1522	sequence-specific DNA binding
A6J67_RS20480	COG0561	phosphatase activity
A6J67_RS20485	COG4533	DNA binding
A6J67_RS20490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6J67_RS20495	COG0824	Thioesterase
A6J67_RS20500	COG1555	photosystem II stabilization
A6J67_RS20505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J67_RS20510	COG0776	regulation of translation
A6J67_RS20515	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J67_RS20520	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J67_RS20525	COG0740	serine-type endopeptidase activity
A6J67_RS20540	COG0271	Belongs to the BolA IbaG family
A6J67_RS20545	COG3056	Lipoprotein
A6J67_RS20550	COG2223	nitrite transmembrane transporter activity
A6J67_RS20560	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A6J67_RS20565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A6J67_RS20570	COG1845	cytochrome c oxidase, subunit III
A6J67_RS20575	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A6J67_RS20580	COG0109	protoheme IX farnesyltransferase activity
A6J67_RS20585	COG2814	Major facilitator Superfamily
A6J67_RS20590	COG1666	GTP binding
A6J67_RS20600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6J67_RS20605	COG0693	protein deglycase activity
A6J67_RS20620	COG0142	geranyltranstransferase activity
A6J67_RS20625	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J67_RS20630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J67_RS20635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J67_RS20645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6J67_RS20650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J67_RS20650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J67_RS20655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J67_RS20665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J67_RS20670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J67_RS20675	COG1862	Preprotein translocase
A6J67_RS20690	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6J67_RS20695	COG0450	alkyl hydroperoxide reductase
A6J67_RS20710	COG0366	Alpha amylase catalytic
A6J67_RS20730	COG5002	protein histidine kinase activity
A6J67_RS20735	COG0745	RESPONSE REGULATOR receiver
A6J67_RS20740	COG0420	3'-5' exonuclease activity
A6J67_RS20745	COG0419	ATPase involved in DNA repair
A6J67_RS20750	COG1940	carbohydrate kinase activity
A6J67_RS20755	COG2974	May be involved in recombination
A6J67_RS20760	COG3123	guanosine phosphorylase activity
A6J67_RS20765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J67_RS20785	COG2226	methyltransferase
A6J67_RS20800	COG3459	Glycosyltransferase 36 associated
A6J67_RS20810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6J67_RS20815	COG2313	pseudouridylate synthase activity
A6J67_RS20820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6J67_RS20825	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J67_RS20830	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J67_RS20840	COG1073	alpha beta
A6J67_RS20850	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J67_RS20855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J67_RS20860	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J67_RS20870	COG2991	Protein conserved in bacteria
A6J67_RS20875	COG1477	protein flavinylation
A6J67_RS20880	COG2871	sodium ion transport
A6J67_RS20885	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J67_RS20890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J67_RS20895	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6J67_RS20900	COG1805	sodium ion transport
A6J67_RS20910	COG3034	peptidoglycan biosynthetic process
A6J67_RS20915	COG0121	glutamine amidotransferase
A6J67_RS20920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J67_RS20925	COG1960	acyl-CoA dehydrogenase activity
A6J67_RS20930	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
A6J67_RS20950	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A6J67_RS20960	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A6J67_RS20970	COG0235	Class ii aldolase
A6J67_RS20975	COG0436	Aminotransferase
A6J67_RS20990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6J67_RS21000	COG2814	Major facilitator Superfamily
A6J67_RS21005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6J67_RS21015	COG1846	Transcriptional regulator
A6J67_RS21030	COG1566	PFAM secretion protein HlyD family protein
A6J67_RS21035	COG2814	Major facilitator Superfamily
A6J67_RS21040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J67_RS21045	COG3118	belongs to the thioredoxin family
A6J67_RS21050	COG3148	PFAM DTW domain containing protein
A6J67_RS21055	COG0045	succinate-CoA ligase (ADP-forming) activity
A6J67_RS21055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J67_RS21055	COG1042	CoA-binding domain protein
A6J67_RS21060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J67_RS21065	COG5544	Lipoprotein
A6J67_RS21095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J67_RS21105	COG2011	ABC-type metal ion transport system permease component
A6J67_RS21110	COG1464	Belongs to the NlpA lipoprotein family
A6J67_RS21120	COG1720	tRNA m6t6A37 methyltransferase activity
A6J67_RS21125	COG0442	prolyl-tRNA aminoacylation
A6J67_RS21130	COG3015	lipoprotein NlpE involved in copper resistance
A6J67_RS21140	COG4681	YaeQ
A6J67_RS21150	COG4568	rho-dependent transcription termination
A6J67_RS21165	COG0346	lactoylglutathione lyase activity
A6J67_RS21170	COG1982	Orn Lys Arg decarboxylase major
A6J67_RS21175	COG0825	malonyl-CoA metabolic process
A6J67_RS21180	COG0587	DNA-directed DNA polymerase activity
A6J67_RS21185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J67_RS21195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J67_RS21200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J67_RS21205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J67_RS21210	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6J67_RS21220	COG0750	zinc metalloprotease
A6J67_RS21225	COG0575	Belongs to the CDS family
A6J67_RS21235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6J67_RS21240	COG0233	cytoplasmic translational termination
A6J67_RS21245	COG0528	UMP kinase activity
A6J67_RS21250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J67_RS21255	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J67_RS21265	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6J67_RS21270	COG2171	N-acyltransferase activity
A6J67_RS21285	COG0564	pseudouridine synthase activity
A6J67_RS21290	COG3098	single-species biofilm formation
A6J67_RS21300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J67_RS21300	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J67_RS21305	COG1611	Belongs to the LOG family
A6J67_RS21310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J67_RS21315	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6J67_RS21320	COG2363	Small membrane protein
A6J67_RS21325	COG0583	DNA-binding transcription factor activity
A6J67_RS21335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J67_RS21340	COG2166	iron-sulfur cluster assembly
A6J67_RS21345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6J67_RS21350	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6J67_RS21370	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6J67_RS21375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J67_RS21375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6J67_RS21385	COG1074	ATP-dependent DNA helicase activity
A6J67_RS21390	COG1025	Belongs to the peptidase M16 family
A6J67_RS21395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6J67_RS21410	COG4795	General secretion pathway protein
A6J67_RS21415	COG2165	general secretion pathway protein
A6J67_RS21440	COG3066	DNA modification
A6J67_RS21445	COG0861	Integral membrane protein TerC family
A6J67_RS21455	COG0667	Aldo Keto reductase
A6J67_RS21460	COG0477	Major facilitator Superfamily
A6J67_RS21465	COG0318	PFAM AMP-dependent synthetase and ligase
A6J67_RS21465	COG0204	Acyl-transferase
A6J67_RS21475	COG1609	Transcriptional regulator
A6J67_RS21490	COG0583	DNA-binding transcription factor activity
A6J67_RS21495	COG0583	DNA-binding transcription factor activity
A6J67_RS21555	COG2165	general secretion pathway protein
A6J67_RS21590	COG0288	reversible hydration of carbon dioxide
A6J67_RS21595	COG1733	regulation of RNA biosynthetic process
A6J67_RS21600	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS21610	COG0484	heat shock protein binding
A6J67_RS21620	COG2271	Major facilitator Superfamily
A6J67_RS21635	COG1522	sequence-specific DNA binding
A6J67_RS21640	COG3706	GGDEF domain
A6J67_RS21670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J67_RS21675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6J67_RS21680	COG4974	Belongs to the 'phage' integrase family
A6J67_RS21685	COG0716	FMN binding
A6J67_RS21690	COG4452	Inner membrane protein CreD
A6J67_RS21695	COG2205	protein histidine kinase activity
A6J67_RS21700	COG0745	RESPONSE REGULATOR receiver
A6J67_RS21715	COG0354	folic acid binding
A6J67_RS21730	COG1028	Short-chain dehydrogenase reductase Sdr
A6J67_RS21735	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J67_RS21735	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6J67_RS21740	COG0509	glycine decarboxylation via glycine cleavage system
A6J67_RS21745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6J67_RS21750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J67_RS21755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6J67_RS21760	COG0006	proline dipeptidase activity
A6J67_RS21765	COG3079	Belongs to the UPF0149 family
A6J67_RS21770	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6J67_RS21780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J67_RS21785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J67_RS21790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J67_RS21795	COG0583	DNA-binding transcription factor activity
A6J67_RS21805	COG1279	arginine transmembrane transporter activity
A6J67_RS21815	COG0191	fructose-bisphosphate aldolase activity
A6J67_RS21820	COG0126	phosphoglycerate kinase activity
A6J67_RS21825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J67_RS21830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J67_RS21835	COG0501	Belongs to the peptidase M48B family
A6J67_RS21845	COG1166	arginine decarboxylase activity
A6J67_RS21855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J67_RS21870	COG0640	Transcriptional regulator
A6J67_RS21875	COG3091	SprT-like family
A6J67_RS21880	COG2356	endonuclease I
A6J67_RS21885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J67_RS21890	COG0189	ligase activity
A6J67_RS21895	COG1678	Uncharacterized ACR, COG1678
A6J67_RS21900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J67_RS21905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6J67_RS21915	COG2805	Type II/IV secretion system protein
A6J67_RS21920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J67_RS21925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J67_RS21930	COG0762	integral membrane protein
A6J67_RS21935	COG1872	DUF167
A6J67_RS21940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J67_RS21945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J67_RS21960	COG3171	Protein conserved in bacteria
A6J67_RS21965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J67_RS21970	COG1194	a g-specific adenine glycosylase
A6J67_RS21980	COG0741	lytic transglycosylase activity
A6J67_RS21990	COG1982	Orn Lys Arg decarboxylase major
A6J67_RS22020	COG0288	reversible hydration of carbon dioxide
A6J67_RS22035	COG2198	Histidine kinase
A6J67_RS22035	COG0784	Response regulator, receiver
A6J67_RS22035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J67_RS22035	COG2205	protein histidine kinase activity
A6J67_RS22040	COG2197	response regulator
A6J67_RS22045	COG2197	response regulator
A6J67_RS22130	COG3121	Chaperone
A6J67_RS22190	COG2197	response regulator
A6J67_RS22240	COG2207	Transcriptional regulator
A6J67_RS22265	COG4303	Ethanolamine ammonia lyase large subunit
A6J67_RS22295	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A6J67_RS22300	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A6J67_RS22315	COG4766	ethanolamine catabolic process
A6J67_RS22325	COG4810	utilization protein
A6J67_RS22330	COG3916	Acyl-homoserine-lactone synthase
A6J67_RS22335	COG2771	luxR family
A6J67_RS22340	COG2188	Transcriptional regulator
A6J67_RS22360	COG1263	PTS System
A6J67_RS22360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J67_RS22360	COG2190	(PTS) system
A6J67_RS22365	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6J67_RS22380	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J67_RS22400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J67_RS22415	COG0300	oxidoreductase activity
A6J67_RS22425	COG0789	Transcriptional regulator
A6J67_RS22430	COG3038	cytochrome b561
A6J67_RS22470	COG0833	amino acid
A6J67_RS22475	COG2040	homocysteine
A6J67_RS22560	COG3547	Transposase (IS116 IS110 IS902 family)
A6J67_RS22585	COG3188	usher protein
A6J67_RS22590	COG3121	Chaperone
A6J67_RS22595	COG3121	Chaperone
A6J67_RS22630	COG1289	transmembrane transporter activity
A6J67_RS22690	COG4604	ABC transporter, ATP-binding protein
A6J67_RS22695	COG4605	iron ion homeostasis
A6J67_RS22705	COG4607	ABC-type enterochelin transport system periplasmic component
A6J67_RS22710	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6J67_RS22715	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J67_RS22720	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6J67_RS22745	COG0477	Major facilitator Superfamily
A6J67_RS22750	COG4302	ethanolamine ammonia-lyase activity
A6J67_RS22755	COG4303	Ethanolamine ammonia lyase large subunit
A6J67_RS22765	COG5001	Diguanylate cyclase
A6J67_RS22770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6J67_RS22775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A6J67_RS22780	COG0309	Hydrogenase expression formation protein (HypE)
A6J67_RS22785	COG0409	Hydrogenase expression formation protein
A6J67_RS22790	COG0298	carbon dioxide binding
A6J67_RS22795	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A6J67_RS22805	COG1773	rubredoxin
A6J67_RS22810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A6J67_RS22815	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A6J67_RS22825	COG0437	4 iron, 4 sulfur cluster binding
A6J67_RS22830	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A6J67_RS22835	COG3133	Outer membrane lipoprotein
A6J67_RS22855	COG0840	transmembrane signaling receptor activity
A6J67_RS22860	COG4592	Periplasmic binding protein
A6J67_RS22865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J67_RS22870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J67_RS22875	COG1120	ATPase activity
A6J67_RS22900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J67_RS22935	COG4964	Belongs to the GSP D family