locus-tag	class	description
F0T03_RS00005	COG0716	FMN binding
F0T03_RS00010	COG1522	sequence-specific DNA binding
F0T03_RS00015	COG2502	aspartate--ammonia ligase
F0T03_RS00025	COG2425	protein containing a von Willebrand factor type A (vWA) domain
F0T03_RS00030	COG0714	Associated with various cellular activities
F0T03_RS00035	COG3158	transport of potassium into the cell
F0T03_RS00040	COG1869	D-ribose catabolic process
F0T03_RS00050	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS00055	COG1879	ABC-type sugar transport system periplasmic component
F0T03_RS00060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0T03_RS00065	COG1609	Transcriptional regulator
F0T03_RS00070	COG0477	Major facilitator Superfamily
F0T03_RS00075	COG2186	Transcriptional regulator
F0T03_RS00105	COG1763	Mo-molybdopterin cofactor biosynthetic process
F0T03_RS00115	COG3084	Protein conserved in bacteria
F0T03_RS00120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F0T03_RS00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0T03_RS00130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0T03_RS00130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0T03_RS00135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F0T03_RS00140	COG3078	GTPase activator activity
F0T03_RS00145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0T03_RS00155	COG3852	Histidine kinase
F0T03_RS00160	COG0174	glutamine synthetase
F0T03_RS00170	COG1011	Hydrolase
F0T03_RS00175	COG1295	ribonuclease BN
F0T03_RS00180	COG1490	D-aminoacyl-tRNA deacylase activity
F0T03_RS00185	COG0456	acetyltransferase
F0T03_RS00190	COG3423	Transcriptional regulator
F0T03_RS00205	COG2982	Protein involved in outer membrane biogenesis
F0T03_RS00210	COG2233	PERMEase
F0T03_RS00215	COG0786	glutamate:sodium symporter activity
F0T03_RS00220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F0T03_RS00225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0T03_RS00230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0T03_RS00235	COG1758	RNA polymerase activity
F0T03_RS00245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0T03_RS00250	COG2860	membrane
F0T03_RS00260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0T03_RS00265	COG1024	Enoyl-CoA hydratase
F0T03_RS00270	COG5001	Diguanylate cyclase
F0T03_RS00280	COG1561	YicC-like family, N-terminal region
F0T03_RS00290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F0T03_RS00295	COG1309	transcriptional regulator
F0T03_RS00300	COG0756	dUTP diphosphatase activity
F0T03_RS00305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F0T03_RS00315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F0T03_RS00320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F0T03_RS00325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F0T03_RS00330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F0T03_RS00340	COG1519	Transferase
F0T03_RS00345	COG0859	PFAM glycosyl transferase family 9
F0T03_RS00350	COG0859	PFAM glycosyl transferase family 9
F0T03_RS00355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0T03_RS00360	COG0156	8-amino-7-oxononanoate synthase activity
F0T03_RS00370	COG2861	carbohydrate metabolic process
F0T03_RS00375	COG4942	peptidase
F0T03_RS00380	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F0T03_RS00385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0T03_RS00390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0T03_RS00395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F0T03_RS00400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F0T03_RS00405	COG1045	serine acetyltransferase
F0T03_RS00410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F0T03_RS00415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0T03_RS00415	COG2169	Transcriptional regulator
F0T03_RS00420	COG2205	protein histidine kinase activity
F0T03_RS00425	COG0745	RESPONSE REGULATOR receiver
F0T03_RS00430	COG3678	ATP-independent chaperone mediated protein folding
F0T03_RS00435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0T03_RS00445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F0T03_RS00455	COG0149	triose-phosphate isomerase activity
F0T03_RS00465	COG3152	Membrane
F0T03_RS00475	COG2814	Major facilitator Superfamily
F0T03_RS00480	COG1494	fructose-1,6-bisphosphatase
F0T03_RS00490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0T03_RS00495	COG3074	FtsZ-dependent cytokinesis
F0T03_RS00500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
F0T03_RS00505	COG1575	Belongs to the MenA family. Type 1 subfamily
F0T03_RS00510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F0T03_RS00515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F0T03_RS00520	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0T03_RS00525	COG1609	Transcriptional regulator
F0T03_RS00530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F0T03_RS00535	COG0254	rRNA binding
F0T03_RS00540	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
F0T03_RS00545	COG0626	cystathionine gamma-synthase activity
F0T03_RS00550	COG0527	aspartate kinase activity
F0T03_RS00550	COG0460	homoserine dehydrogenase
F0T03_RS00565	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
F0T03_RS00575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F0T03_RS00580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0T03_RS00585	COG0165	Argininosuccinate lyase
F0T03_RS00620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0T03_RS00625	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0T03_RS00625	COG0678	peroxiredoxin activity
F0T03_RS00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0T03_RS00640	COG1309	transcriptional regulator
F0T03_RS00650	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0T03_RS00660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F0T03_RS00705	COG1879	ABC-type sugar transport system periplasmic component
F0T03_RS00710	COG1129	ABC transporter
F0T03_RS00715	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS00720	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS00725	COG0583	DNA-binding transcription factor activity
F0T03_RS00730	COG3085	chromosome segregation
F0T03_RS00750	COG3978	acetolactate synthase activity
F0T03_RS00755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0T03_RS00760	COG0129	dihydroxy-acid dehydratase activity
F0T03_RS00765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F0T03_RS00770	COG0583	DNA-binding transcription factor activity
F0T03_RS00775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F0T03_RS00785	COG3121	Chaperone
F0T03_RS00800	COG3121	Chaperone
F0T03_RS00810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0T03_RS00825	COG0248	Ppx GppA phosphatase
F0T03_RS00835	COG3118	belongs to the thioredoxin family
F0T03_RS00840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F0T03_RS00845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0T03_RS00850	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
F0T03_RS00855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F0T03_RS00860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
F0T03_RS00865	COG1088	dTDP-glucose 4,6-dehydratase activity
F0T03_RS00870	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F0T03_RS00875	COG0456	acetyltransferase
F0T03_RS00880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0T03_RS00885	COG2244	polysaccharide biosynthetic process
F0T03_RS00890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0T03_RS00905	COG1113	amino acid transport
F0T03_RS00930	COG3071	HemY protein
F0T03_RS00935	COG2959	enzyme of heme biosynthesis
F0T03_RS00940	COG1587	Uroporphyrinogen-III synthase
F0T03_RS00945	COG0181	hydroxymethylbilane synthase activity
F0T03_RS00950	COG3072	Adenylate cyclase
F0T03_RS00955	COG1965	Belongs to the frataxin family
F0T03_RS00960	COG5567	small periplasmic lipoprotein
F0T03_RS00965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F0T03_RS00970	COG3159	Protein conserved in bacteria
F0T03_RS00975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
F0T03_RS00980	COG1011	Hydrolase
F0T03_RS00985	COG0210	DNA helicase
F0T03_RS00995	COG5441	Belongs to the UPF0261 family
F0T03_RS01000	COG5564	TIM-barrel signal transduction protein
F0T03_RS01010	COG0598	Magnesium transport protein CorA
F0T03_RS01020	COG2050	protein possibly involved in aromatic compounds catabolism
F0T03_RS01025	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
F0T03_RS01030	COG0514	ATP-dependent DNA helicase (RecQ)
F0T03_RS01035	COG1280	lysine exporter protein (LysE YggA)
F0T03_RS01045	COG2267	carboxylic ester hydrolase activity
F0T03_RS01050	COG0561	phosphatase activity
F0T03_RS01055	COG0584	glycerophosphoryl diester phosphodiesterase
F0T03_RS01060	COG2271	Major facilitator Superfamily
F0T03_RS01065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0T03_RS01070	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
F0T03_RS01075	COG0247	lactate metabolic process
F0T03_RS01085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F0T03_RS01090	COG0425	Belongs to the sulfur carrier protein TusA family
F0T03_RS01100	COG3714	YhhN family
F0T03_RS01115	COG3776	membrane
F0T03_RS01120	COG0742	ribosomal rna small subunit methyltransferase
F0T03_RS01125	COG0552	protein localization to endoplasmic reticulum
F0T03_RS01130	COG2884	Cell division ATP-binding protein ftsE
F0T03_RS01135	COG2177	Part of the ABC transporter FtsEX involved in
F0T03_RS01150	COG0683	leucine binding
F0T03_RS01155	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS01160	COG4177	L-phenylalanine transmembrane transporter activity
F0T03_RS01165	COG0411	ABC transporter
F0T03_RS01170	COG0410	ABC transporter
F0T03_RS01205	COG1653	transport
F0T03_RS01210	COG1175	transmembrane transport
F0T03_RS01215	COG0395	ABC-type sugar transport system, permease component
F0T03_RS01220	COG3842	ATPase activity
F0T03_RS01225	COG0584	glycerophosphoryl diester phosphodiesterase
F0T03_RS01230	COG0679	Auxin Efflux Carrier
F0T03_RS01240	COG0583	DNA-binding transcription factor activity
F0T03_RS01245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F0T03_RS01250	COG0412	Dienelactone hydrolase
F0T03_RS01255	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
F0T03_RS01265	COG1966	Carbon starvation protein
F0T03_RS01270	COG0586	Pfam SNARE associated Golgi protein
F0T03_RS01275	COG1322	Protein conserved in bacteria
F0T03_RS01280	COG2226	methyltransferase
F0T03_RS01290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F0T03_RS01295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0T03_RS01300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0T03_RS01305	COG0805	protein transport
F0T03_RS01325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F0T03_RS01335	COG0183	Belongs to the thiolase family
F0T03_RS01340	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0T03_RS01340	COG1024	Enoyl-CoA hydratase
F0T03_RS01350	COG1739	Uncharacterized protein family UPF0029
F0T03_RS01355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F0T03_RS01395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F0T03_RS01400	COG3162	membrane
F0T03_RS01405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F0T03_RS01410	COG1301	dicarboxylic acid transport
F0T03_RS01575	COG2391	methyltransferase activity
F0T03_RS01580	COG0425	Belongs to the sulfur carrier protein TusA family
F0T03_RS01585	COG3264	Mechanosensitive ion channel
F0T03_RS01585	COG1511	domain protein
F0T03_RS01590	COG4774	siderophore transport
F0T03_RS01595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0T03_RS01625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0T03_RS01630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0T03_RS01635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0T03_RS01640	COG4558	Periplasmic binding protein
F0T03_RS01645	COG3720	iron ion transport
F0T03_RS01665	COG3721	Heme iron utilization protein
F0T03_RS01700	COG2831	hemolysin activation secretion protein
F0T03_RS01705	COG3210	domain, Protein
F0T03_RS01755	COG3210	domain, Protein
F0T03_RS01825	COG0305	Participates in initiation and elongation during chromosome replication
F0T03_RS01860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0T03_RS01935	COG1192	Involved in chromosome partitioning
F0T03_RS01995	COG1204	response to ionizing radiation
F0T03_RS02100	COG2132	Multicopper oxidase
F0T03_RS02115	COG2205	protein histidine kinase activity
F0T03_RS02120	COG0745	RESPONSE REGULATOR receiver
F0T03_RS02125	COG1276	copper resistance
F0T03_RS02130	COG2372	response to copper ion
F0T03_RS02135	COG3667	copper resistance
F0T03_RS02140	COG2132	Multicopper oxidase
F0T03_RS02155	COG0739	heme binding
F0T03_RS02185	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS02195	COG0745	RESPONSE REGULATOR receiver
F0T03_RS02225	COG1309	transcriptional regulator
F0T03_RS02235	COG2084	Dehydrogenase
F0T03_RS02240	COG1929	Belongs to the glycerate kinase type-1 family
F0T03_RS02245	COG3835	regulator
F0T03_RS02255	COG0493	'glutamate synthase
F0T03_RS02255	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0T03_RS02260	COG3383	formate dehydrogenase (NAD+) activity
F0T03_RS02265	COG4232	protein-disulfide reductase activity
F0T03_RS02275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0T03_RS02290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F0T03_RS02295	COG0459	protein refolding
F0T03_RS02310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0T03_RS02320	COG2076	Multidrug Resistance protein
F0T03_RS02330	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0T03_RS02335	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
F0T03_RS02340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F0T03_RS02345	COG1053	succinate dehydrogenase
F0T03_RS02350	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F0T03_RS02355	COG1511	domain protein
F0T03_RS02355	COG3264	Mechanosensitive ion channel
F0T03_RS02360	COG0688	phosphatidylethanolamine metabolic process
F0T03_RS02365	COG1162	GTPase activity
F0T03_RS02370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
F0T03_RS02390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F0T03_RS02395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F0T03_RS02395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F0T03_RS02400	COG0802	atpase or kinase
F0T03_RS02405	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0T03_RS02410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F0T03_RS02415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F0T03_RS02420	COG1923	regulation of RNA biosynthetic process
F0T03_RS02425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F0T03_RS02430	COG0330	HflC and HflK could
F0T03_RS02435	COG0330	HflC and HflK could
F0T03_RS02440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
F0T03_RS02445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F0T03_RS02450	COG1959	2 iron, 2 sulfur cluster binding
F0T03_RS02455	COG0557	exoribonuclease II activity
F0T03_RS02460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0T03_RS02465	COG1960	acyl-CoA dehydrogenase activity
F0T03_RS02470	COG3650	response to hydrogen peroxide
F0T03_RS02475	COG1073	alpha beta
F0T03_RS02490	COG0360	Binds together with S18 to 16S ribosomal RNA
F0T03_RS02495	COG2965	DNA replication, synthesis of RNA primer
F0T03_RS02500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F0T03_RS02505	COG0359	binds to the 23S rRNA
F0T03_RS02515	COG3061	Opacity-associated protein A
F0T03_RS02520	COG0545	Peptidyl-prolyl cis-trans isomerase
F0T03_RS02530	COG0737	Belongs to the 5'-nucleotidase family
F0T03_RS02535	COG1218	3'(2'),5'-bisphosphate nucleotidase
F0T03_RS02540	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
F0T03_RS02550	COG1253	flavin adenine dinucleotide binding
F0T03_RS02555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F0T03_RS02560	COG0729	surface antigen
F0T03_RS02570	COG2105	PFAM AIG2 family protein
F0T03_RS02575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F0T03_RS02580	COG0840	transmembrane signaling receptor activity
F0T03_RS02585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F0T03_RS02590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0T03_RS02605	COG1438	arginine binding
F0T03_RS02610	COG0039	L-malate dehydrogenase activity
F0T03_RS02615	COG3423	Transcriptional regulator
F0T03_RS02625	COG0142	geranyltranstransferase activity
F0T03_RS02640	COG0697	spore germination
F0T03_RS02645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F0T03_RS02650	COG0642	Histidine kinase
F0T03_RS02655	COG0745	RESPONSE REGULATOR receiver
F0T03_RS02660	COG2027	D-alanyl-D-alanine carboxypeptidase
F0T03_RS02665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0T03_RS02670	COG1534	Rna-binding protein
F0T03_RS02675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F0T03_RS02680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F0T03_RS02685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F0T03_RS02690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F0T03_RS02695	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0T03_RS02710	COG0779	Required for maturation of 30S ribosomal subunits
F0T03_RS02715	COG0195	Participates in both transcription termination and antitermination
F0T03_RS02720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F0T03_RS02725	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F0T03_RS02730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F0T03_RS02740	COG1185	polyribonucleotide nucleotidyltransferase activity
F0T03_RS02755	COG0513	Belongs to the DEAD box helicase family
F0T03_RS02760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F0T03_RS02770	COG0814	amino acid
F0T03_RS02775	COG3681	Belongs to the UPF0597 family
F0T03_RS02800	COG3153	acetyltransferase
F0T03_RS02810	COG0531	amino acid
F0T03_RS02815	COG1982	Orn Lys Arg decarboxylase major
F0T03_RS02835	COG1653	transport
F0T03_RS02845	COG0395	ABC-type sugar transport system, permease component
F0T03_RS02850	COG3842	ATPase activity
F0T03_RS02860	COG3787	Belongs to the UPF0306 family
F0T03_RS02865	COG0702	epimerase
F0T03_RS02870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F0T03_RS02875	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F0T03_RS02880	COG3454	Phosphonate metabolism
F0T03_RS02885	COG4778	phosphonate C-P lyase system protein PhnL
F0T03_RS02890	COG4107	phosphonate C-P lyase system protein PhnK
F0T03_RS02895	COG3627	carbon phosphorus lyase activity
F0T03_RS02900	COG3626	phosphonate metabolism
F0T03_RS02905	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
F0T03_RS02910	COG3624	Phosphonate C-P lyase system protein PhnG
F0T03_RS02915	COG2188	Transcriptional regulator
F0T03_RS02930	COG0583	DNA-binding transcription factor activity
F0T03_RS02935	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0T03_RS02940	COG4608	Belongs to the ABC transporter superfamily
F0T03_RS02945	COG0444	Belongs to the ABC transporter superfamily
F0T03_RS02955	COG0601	transmembrane transport
F0T03_RS02965	COG2731	YhcH YjgK YiaL family protein
F0T03_RS02975	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
F0T03_RS02995	COG2927	DNA polymerase III (CHI subunit)
F0T03_RS03000	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F0T03_RS03005	COG0795	lipopolysaccharide-transporting ATPase activity
F0T03_RS03010	COG0795	lipopolysaccharide-transporting ATPase activity
F0T03_RS03020	COG0582	viral genome integration into host DNA
F0T03_RS03085	COG3596	GTP binding
F0T03_RS03095	COG2378	regulation of single-species biofilm formation
F0T03_RS03115	COG2003	Belongs to the UPF0758 family
F0T03_RS03160	COG0454	-acetyltransferase
F0T03_RS03180	COG3272	Protein of unknown function (DUF1722)
F0T03_RS03185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0T03_RS03190	COG1830	Aldolase
F0T03_RS03195	COG1879	ABC-type sugar transport system periplasmic component
F0T03_RS03200	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS03205	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS03210	COG1129	ABC transporter
F0T03_RS03215	COG2390	Transcriptional regulator
F0T03_RS03220	COG1070	Carbohydrate kinase
F0T03_RS03230	COG0859	PFAM glycosyl transferase family 9
F0T03_RS03245	COG2235	arginine
F0T03_RS03255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS03260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS03270	COG2376	Dihydroxyacetone kinase
F0T03_RS03275	COG1461	Dihydroxyacetone kinase
F0T03_RS03280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0T03_RS03280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS03280	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
F0T03_RS03290	COG2192	nodulation
F0T03_RS03350	COG3706	GGDEF domain
F0T03_RS03375	COG0583	DNA-binding transcription factor activity
F0T03_RS03380	COG0667	Aldo Keto reductase
F0T03_RS03385	COG2813	Specifically methylates the guanine in position
F0T03_RS03390	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
F0T03_RS03395	COG0456	acetyltransferase
F0T03_RS03400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F0T03_RS03405	COG2823	Periplasmic or secreted lipoprotein
F0T03_RS03415	COG4667	esterase of the alpha-beta hydrolase superfamily
F0T03_RS03420	COG0084	hydrolase, TatD family'
F0T03_RS03425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0T03_RS03430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0T03_RS03435	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F0T03_RS03440	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0T03_RS03450	COG3726	membrane protein affecting hemolysin expression
F0T03_RS03455	COG0560	Phosphoserine phosphatase
F0T03_RS03470	COG0604	alcohol dehydrogenase
F0T03_RS03480	COG0488	(ABC) transporter
F0T03_RS03485	COG2885	chlorophyll binding
F0T03_RS03490	COG2199	diguanylate cyclase activity
F0T03_RS03500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0T03_RS03505	COG0741	lytic transglycosylase activity
F0T03_RS03510	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
F0T03_RS03515	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
F0T03_RS03520	COG0406	alpha-ribazole phosphatase activity
F0T03_RS03525	COG2207	Transcriptional regulator
F0T03_RS03525	COG3708	Transcriptional regulator
F0T03_RS03530	COG3045	CreA protein
F0T03_RS03535	COG0745	RESPONSE REGULATOR receiver
F0T03_RS03550	COG0083	homoserine kinase activity
F0T03_RS03560	COG3022	response to hydroperoxide
F0T03_RS03565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0T03_RS03570	COG0521	Mo-molybdopterin cofactor biosynthetic process
F0T03_RS03585	COG1584	GPR1 FUN34 yaaH family protein
F0T03_RS03595	COG0484	heat shock protein binding
F0T03_RS03600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0T03_RS03605	COG0583	DNA-binding transcription factor activity
F0T03_RS03625	COG0196	riboflavin kinase activity
F0T03_RS03630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F0T03_RS03635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F0T03_RS03640	COG1047	Peptidyl-prolyl cis-trans
F0T03_RS03645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F0T03_RS03650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F0T03_RS03655	COG0505	Belongs to the CarA family
F0T03_RS03660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0T03_RS03665	COG1280	lysine exporter protein (LysE YggA)
F0T03_RS03670	COG2966	Psort location CytoplasmicMembrane, score
F0T03_RS03675	COG3610	response to peptide
F0T03_RS03680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F0T03_RS03690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0T03_RS03695	COG2967	ApaG domain
F0T03_RS03705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F0T03_RS03710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0T03_RS03715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0T03_RS03730	COG0564	pseudouridine synthase activity
F0T03_RS03735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F0T03_RS03740	COG0417	DNA replication proofreading
F0T03_RS03745	COG0586	Pfam SNARE associated Golgi protein
F0T03_RS03755	COG1178	ABC-type Fe3 transport system permease component
F0T03_RS03760	COG4143	(ABC) transporter
F0T03_RS03765	COG4533	DNA binding
F0T03_RS03770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0T03_RS03780	COG2814	Major facilitator Superfamily
F0T03_RS03785	COG0814	amino acid
F0T03_RS03790	COG3033	Beta-eliminating lyase
F0T03_RS03805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F0T03_RS03810	COG0473	3-isopropylmalate dehydrogenase activity
F0T03_RS03815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F0T03_RS03830	COG1022	Amp-dependent synthetase and ligase
F0T03_RS03835	COG0028	Belongs to the TPP enzyme family
F0T03_RS03845	COG1609	Transcriptional regulator
F0T03_RS03855	COG2001	Belongs to the MraZ family
F0T03_RS03860	COG0275	rRNA processing
F0T03_RS03865	COG3116	cell division
F0T03_RS03870	COG0768	penicillin binding
F0T03_RS03875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F0T03_RS03880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F0T03_RS03885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F0T03_RS03895	COG0772	Belongs to the SEDS family
F0T03_RS03900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F0T03_RS03905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F0T03_RS03915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F0T03_RS03920	COG0849	cell division
F0T03_RS03925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F0T03_RS03945	COG0653	protein targeting
F0T03_RS03955	COG0494	nUDIX hydrolase
F0T03_RS03960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F0T03_RS03970	COG0237	dephospho-CoA kinase activity
F0T03_RS03975	COG0516	GMP reductase activity
F0T03_RS03985	COG1459	type II secretion system
F0T03_RS03990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F0T03_RS03995	COG4969	Belongs to the N-Me-Phe pilin family
F0T03_RS04005	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0T03_RS04010	COG3725	Membrane protein required for beta-lactamase induction
F0T03_RS04015	COG1113	amino acid transport
F0T03_RS04020	COG2186	Transcriptional regulator
F0T03_RS04025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
F0T03_RS04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0T03_RS04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0T03_RS04045	COG4977	sequence-specific DNA binding
F0T03_RS04055	COG1049	propionate catabolic process, 2-methylcitrate cycle
F0T03_RS04060	COG3112	Uncharacterised protein family (UPF0231)
F0T03_RS04065	COG0697	spore germination
F0T03_RS04070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F0T03_RS04075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F0T03_RS04085	COG2132	Multicopper oxidase
F0T03_RS04090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F0T03_RS04095	COG0288	reversible hydration of carbon dioxide
F0T03_RS04100	COG1131	(ABC) transporter
F0T03_RS04105	COG0842	Transport permease protein
F0T03_RS04110	COG0726	polysaccharide deacetylase
F0T03_RS04115	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F0T03_RS04120	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F0T03_RS04125	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F0T03_RS04130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F0T03_RS04135	COG0617	tRNA 3'-terminal CCA addition
F0T03_RS04145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F0T03_RS04150	COG1489	DNA binding
F0T03_RS04155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F0T03_RS04160	COG1643	Atp-dependent helicase
F0T03_RS04165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0T03_RS04170	COG1120	ATPase activity
F0T03_RS04175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0T03_RS04180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0T03_RS04185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F0T03_RS04195	COG0316	Belongs to the HesB IscA family
F0T03_RS04205	COG2860	membrane
F0T03_RS04215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0T03_RS04220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F0T03_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0T03_RS04230	COG4999	Histidine kinase
F0T03_RS04230	COG3850	Histidine kinase
F0T03_RS04230	COG3437	response regulator, receiver
F0T03_RS04230	COG2205	protein histidine kinase activity
F0T03_RS04235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0T03_RS04240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F0T03_RS04245	COG3956	TIGRFAM MazG family protein
F0T03_RS04250	COG0504	CTP synthase activity
F0T03_RS04255	COG0148	phosphopyruvate hydratase activity
F0T03_RS04265	COG0602	queuosine metabolic process
F0T03_RS04270	COG0720	synthase
F0T03_RS04275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F0T03_RS04280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0T03_RS04285	COG0175	sulfate reduction
F0T03_RS04290	COG2234	aminopeptidase activity
F0T03_RS04295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0T03_RS04295	COG1648	precorrin-2 dehydrogenase activity
F0T03_RS04300	COG0175	sulfate reduction
F0T03_RS04305	COG2895	sulfate adenylyltransferase (ATP) activity
F0T03_RS04310	COG0529	Catalyzes the synthesis of activated sulfate
F0T03_RS04325	COG0765	amino acid transport
F0T03_RS04335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F0T03_RS04345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F0T03_RS04350	COG0585	pseudouridine synthase activity
F0T03_RS04355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F0T03_RS04360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F0T03_RS04365	COG1388	LysM domain
F0T03_RS04365	COG4942	peptidase
F0T03_RS04370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0T03_RS04375	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F0T03_RS04400	COG3188	usher protein
F0T03_RS04405	COG3121	Chaperone
F0T03_RS04420	COG3539	Fimbrial protein
F0T03_RS04425	COG3539	Fimbrial protein
F0T03_RS04440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0T03_RS04455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS04460	COG0577	efflux transmembrane transporter activity
F0T03_RS04460	COG1136	(ABC) transporter
F0T03_RS04465	COG1538	Outer membrane efflux protein
F0T03_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS04490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS04500	COG1858	cytochrome C peroxidase
F0T03_RS04505	COG4948	Mandelate Racemase Muconate Lactonizing
F0T03_RS04510	COG0747	negative chemotaxis
F0T03_RS04515	COG0601	transmembrane transport
F0T03_RS04525	COG0444	Belongs to the ABC transporter superfamily
F0T03_RS04530	COG4608	Belongs to the ABC transporter superfamily
F0T03_RS04535	COG0583	DNA-binding transcription factor activity
F0T03_RS04540	COG2610	gluconate transmembrane transporter activity
F0T03_RS04545	COG3048	D-serine ammonia-lyase activity
F0T03_RS04555	COG0765	amino acid transport
F0T03_RS04560	COG0765	amino acid transport
F0T03_RS04565	COG1126	abc transporter atp-binding protein
F0T03_RS04570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0T03_RS04585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F0T03_RS04590	COG0640	Transcriptional regulator
F0T03_RS04650	COG0410	ABC transporter
F0T03_RS04655	COG1137	ATPase activity
F0T03_RS04660	COG4177	L-phenylalanine transmembrane transporter activity
F0T03_RS04665	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS04675	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F0T03_RS04675	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F0T03_RS04680	COG1070	Carbohydrate kinase
F0T03_RS04685	COG3623	hexulose-6-phosphate isomerase
F0T03_RS04695	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS04700	COG1129	ABC transporter
F0T03_RS04710	COG1349	DNA-binding transcription factor activity
F0T03_RS04715	COG0235	Class ii aldolase
F0T03_RS04720	COG1349	DNA-binding transcription factor activity
F0T03_RS04730	COG1070	Carbohydrate kinase
F0T03_RS04740	COG0738	Major facilitator superfamily
F0T03_RS04745	COG0235	Class ii aldolase
F0T03_RS04750	COG1454	alcohol dehydrogenase
F0T03_RS04755	COG0243	molybdopterin cofactor binding
F0T03_RS04760	COG0437	4 iron, 4 sulfur cluster binding
F0T03_RS04765	COG3302	dmso reductase anchor subunit
F0T03_RS04770	COG3381	protein complex oligomerization
F0T03_RS04775	COG1609	Transcriptional regulator
F0T03_RS04785	COG1129	ABC transporter
F0T03_RS04790	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS04795	COG3959	Transketolase, thiamine diphosphate binding domain
F0T03_RS04800	COG3958	Transketolase
F0T03_RS04805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F0T03_RS04830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F0T03_RS04835	COG2137	regulation of response to DNA damage stimulus
F0T03_RS04840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0T03_RS04845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F0T03_RS04870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0T03_RS04875	COG1238	metal cluster binding
F0T03_RS04880	COG2918	glutathione biosynthetic process
F0T03_RS04885	COG1854	S-ribosylhomocysteine lyase activity
F0T03_RS04890	COG4536	flavin adenine dinucleotide binding
F0T03_RS04895	COG4137	Cytochrome C assembly protein
F0T03_RS04900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F0T03_RS04905	COG0228	four-way junction DNA binding
F0T03_RS04910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F0T03_RS04915	COG0336	Belongs to the RNA methyltransferase TrmD family
F0T03_RS04920	COG0335	large ribosomal subunit rRNA binding
F0T03_RS04925	COG3137	Salt-induced outer membrane protein
F0T03_RS04930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
F0T03_RS04935	COG3279	Response regulator of the LytR AlgR family
F0T03_RS04940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0T03_RS04945	COG0287	Prephenate dehydrogenase
F0T03_RS04945	COG1605	Chorismate mutase
F0T03_RS04950	COG0077	Prephenate dehydratase
F0T03_RS04950	COG1605	Chorismate mutase
F0T03_RS04955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F0T03_RS04960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0T03_RS04965	COG0564	pseudouridine synthase activity
F0T03_RS04975	COG0542	response to heat
F0T03_RS05010	COG0656	L-ascorbic acid biosynthetic process
F0T03_RS05020	COG3021	interspecies interaction between organisms
F0T03_RS05025	COG1388	LysM domain
F0T03_RS05025	COG0741	lytic transglycosylase activity
F0T03_RS05030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0T03_RS05035	COG2226	methyltransferase
F0T03_RS05040	COG0328	RNA-DNA hybrid ribonuclease activity
F0T03_RS05045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0T03_RS05055	COG2113	Glycine betaine
F0T03_RS05060	COG4176	ABC-type proline glycine betaine transport system permease component
F0T03_RS05070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0T03_RS05080	COG1780	Probably involved in ribonucleotide reductase function
F0T03_RS05090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0T03_RS05100	COG4575	ribosome binding
F0T03_RS05115	COG2207	Transcriptional regulator
F0T03_RS05135	COG1278	Cold shock
F0T03_RS05175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0T03_RS05180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F0T03_RS05205	COG0804	urea catabolic process
F0T03_RS05210	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
F0T03_RS05215	COG0830	nickel cation binding
F0T03_RS05220	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F0T03_RS05225	COG0829	nickel cation binding
F0T03_RS05230	COG4413	Urea transporter
F0T03_RS05240	COG3039	Transposase
F0T03_RS05255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0T03_RS05260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0T03_RS05270	COG0667	Aldo Keto reductase
F0T03_RS05275	COG2133	pyrroloquinoline quinone binding
F0T03_RS05280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0T03_RS05285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0T03_RS05290	COG2723	6-phospho-beta-galactosidase activity
F0T03_RS05295	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0T03_RS05300	COG2169	Transcriptional regulator
F0T03_RS05300	COG1917	Cupin 2, conserved barrel domain protein
F0T03_RS05305	COG3394	polysaccharide catabolic process
F0T03_RS05360	COG0582	viral genome integration into host DNA
F0T03_RS05375	COG2867	negative regulation of translational initiation
F0T03_RS05385	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0T03_RS05390	COG0497	DNA recombination
F0T03_RS05395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F0T03_RS05400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F0T03_RS05405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F0T03_RS05410	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
F0T03_RS05425	COG0513	Belongs to the DEAD box helicase family
F0T03_RS05430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F0T03_RS05435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F0T03_RS05445	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
F0T03_RS05455	COG3086	response to oxidative stress
F0T03_RS05465	COG3039	Transposase
F0T03_RS05470	COG0481	GTPase activity
F0T03_RS05475	COG0681	Belongs to the peptidase S26 family
F0T03_RS05480	COG0571	ribonuclease III activity
F0T03_RS05485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F0T03_RS05490	COG1381	Involved in DNA repair and RecF pathway recombination
F0T03_RS05495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F0T03_RS05505	COG2610	gluconate transmembrane transporter activity
F0T03_RS05510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0T03_RS05515	COG1737	Transcriptional regulator
F0T03_RS05525	COG0560	Phosphoserine phosphatase
F0T03_RS05535	COG0590	tRNA wobble adenosine to inosine editing
F0T03_RS05540	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
F0T03_RS05555	COG2205	protein histidine kinase activity
F0T03_RS05560	COG3170	Tfp pilus assembly protein FimV
F0T03_RS05565	COG2204	response regulator
F0T03_RS05570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F0T03_RS05570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0T03_RS05575	COG0347	Belongs to the P(II) protein family
F0T03_RS05590	COG1735	metal-dependent hydrolase with the TIM-barrel fold
F0T03_RS05595	COG3457	Alanine racemase
F0T03_RS05610	COG3039	Transposase
F0T03_RS05620	COG1017	nitric oxide dioxygenase activity
F0T03_RS05620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0T03_RS05625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F0T03_RS05630	COG2814	Major facilitator Superfamily
F0T03_RS05635	COG3711	transcriptional antiterminator
F0T03_RS05640	COG3683	transport system, periplasmic component
F0T03_RS05645	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F0T03_RS05650	COG0483	inositol monophosphate 1-phosphatase activity
F0T03_RS05655	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F0T03_RS05660	COG1959	2 iron, 2 sulfur cluster binding
F0T03_RS05670	COG0822	iron-sulfur transferase activity
F0T03_RS05680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F0T03_RS05685	COG0443	Heat shock 70 kDa protein
F0T03_RS05690	COG0633	Ferredoxin
F0T03_RS05695	COG2975	iron-sulfur cluster assembly
F0T03_RS05710	COG2373	Large extracellular alpha-helical protein
F0T03_RS05715	COG4953	penicillin-binding protein 1C
F0T03_RS05740	COG1426	Protein conserved in bacteria
F0T03_RS05745	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F0T03_RS05750	COG0124	histidyl-tRNA synthetase
F0T03_RS05755	COG2976	Protein conserved in bacteria
F0T03_RS05760	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F0T03_RS05765	COG1160	GTP binding
F0T03_RS05775	COG1645	bacterial-type flagellum-dependent swarming motility
F0T03_RS05780	COG1570	exodeoxyribonuclease VII activity
F0T03_RS05785	COG0516	GMP reductase activity
F0T03_RS05785	COG0517	IMP dehydrogenase activity
F0T03_RS05790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F0T03_RS05790	COG0519	Catalyzes the synthesis of GMP from XMP
F0T03_RS05820	COG0351	phosphomethylpyrimidine kinase
F0T03_RS05840	COG1349	DNA-binding transcription factor activity
F0T03_RS05845	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS05865	COG3730	PTS system glucitol sorbitol-specific
F0T03_RS05870	COG1597	lipid kinase activity
F0T03_RS05880	COG3422	double-strand break repair
F0T03_RS05885	COG0745	RESPONSE REGULATOR receiver
F0T03_RS05890	COG2205	protein histidine kinase activity
F0T03_RS05895	COG0477	Major facilitator Superfamily
F0T03_RS05905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS05915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS05920	COG3539	Fimbrial protein
F0T03_RS05930	COG3121	Chaperone
F0T03_RS05940	COG0443	Heat shock 70 kDa protein
F0T03_RS05945	COG5001	Diguanylate cyclase
F0T03_RS05945	COG3447	MASE1 domain protein
F0T03_RS05945	COG5002	protein histidine kinase activity
F0T03_RS05950	COG2239	Acts as a magnesium transporter
F0T03_RS05960	COG0248	Ppx GppA phosphatase
F0T03_RS05965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F0T03_RS05970	COG0573	inorganic phosphate transmembrane transporter activity
F0T03_RS05975	COG0581	inorganic phosphate transmembrane transporter activity
F0T03_RS05985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0T03_RS05990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F0T03_RS05995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F0T03_RS06000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F0T03_RS06005	COG2233	PERMEase
F0T03_RS06010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0T03_RS06015	COG1393	Belongs to the ArsC family
F0T03_RS06020	COG4783	chaperone-mediated protein folding
F0T03_RS06025	COG0628	permease
F0T03_RS06030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F0T03_RS06035	COG2716	regulation of RNA biosynthetic process
F0T03_RS06040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0T03_RS06045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
F0T03_RS06050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F0T03_RS06055	COG2321	neutral zinc metallopeptidase
F0T03_RS06060	COG2707	UPF0756 membrane protein
F0T03_RS06065	COG1444	tRNA N-acetyltransferase activity
F0T03_RS06070	COG0400	carboxylic ester hydrolase activity
F0T03_RS06080	COG1876	peptidase activity
F0T03_RS06085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F0T03_RS06090	COG1393	Belongs to the ArsC family
F0T03_RS06100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS06110	COG2197	response regulator
F0T03_RS06120	COG3062	negative regulation of establishment of protein localization
F0T03_RS06125	COG0243	molybdopterin cofactor binding
F0T03_RS06130	COG3043	anaerobic respiration
F0T03_RS06135	COG3005	denitrification pathway
F0T03_RS06140	COG0494	nUDIX hydrolase
F0T03_RS06150	COG1671	Belongs to the UPF0178 family
F0T03_RS06155	COG0408	coproporphyrinogen oxidase activity
F0T03_RS06160	COG0456	acetyltransferase
F0T03_RS06255	COG3111	PFAM Bacterial OB fold (BOF) protein
F0T03_RS06265	COG2837	iron assimilation
F0T03_RS06270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F0T03_RS06285	COG2731	YhcH YjgK YiaL family protein
F0T03_RS06290	COG1737	Transcriptional regulator
F0T03_RS06300	COG4150	thiosulfate binding
F0T03_RS06305	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F0T03_RS06310	COG4208	sulfate ABC transporter
F0T03_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS06335	COG0745	RESPONSE REGULATOR receiver
F0T03_RS06340	COG2205	protein histidine kinase activity
F0T03_RS06345	COG2190	(PTS) system
F0T03_RS06350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0T03_RS06355	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS06360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0T03_RS06365	COG0582	viral genome integration into host DNA
F0T03_RS06405	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0T03_RS06410	COG5532	Uncharacterized conserved protein (DUF2303)
F0T03_RS06475	COG3646	Phage regulatory protein
F0T03_RS06475	COG3645	SOS response
F0T03_RS06480	COG1403	HNH endonuclease
F0T03_RS06490	COG1724	mRNA binding
F0T03_RS06495	COG1598	PFAM Uncharacterised protein family UPF0150
F0T03_RS06510	COG3179	chitinase
F0T03_RS06590	COG4386	tail sheath protein
F0T03_RS06630	COG4381	Mu-like prophage protein gp46
F0T03_RS06635	COG3299	homolog of phage Mu protein gp47
F0T03_RS06665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
F0T03_RS06675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F0T03_RS06680	COG3530	Putative quorum-sensing-regulated virulence factor
F0T03_RS06705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0T03_RS06735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0T03_RS06740	COG1914	H( )-stimulated, divalent metal cation uptake system
F0T03_RS06750	COG0667	Aldo Keto reductase
F0T03_RS06755	COG3961	Belongs to the TPP enzyme family
F0T03_RS06770	COG0837	glucose binding
F0T03_RS06775	COG2223	nitrite transmembrane transporter activity
F0T03_RS06780	COG3279	Response regulator of the LytR AlgR family
F0T03_RS06785	COG3275	phosphorelay sensor kinase activity
F0T03_RS06800	COG0436	Aminotransferase
F0T03_RS06805	COG3038	cytochrome b561
F0T03_RS06815	COG1598	PFAM Uncharacterised protein family UPF0150
F0T03_RS06840	COG3381	protein complex oligomerization
F0T03_RS06850	COG0437	4 iron, 4 sulfur cluster binding
F0T03_RS06855	COG0243	molybdopterin cofactor binding
F0T03_RS06870	COG2723	6-phospho-beta-galactosidase activity
F0T03_RS06885	COG1280	lysine exporter protein (LysE YggA)
F0T03_RS06905	COG2951	lytic endotransglycosylase activity
F0T03_RS06910	COG0531	amino acid
F0T03_RS06930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0T03_RS06935	COG1127	ABC transporter
F0T03_RS06950	COG3038	cytochrome b561
F0T03_RS06955	COG2353	YceI-like domain
F0T03_RS06960	COG1609	Transcriptional regulator
F0T03_RS06965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS06965	COG1263	PTS System
F0T03_RS06970	COG2723	6-phospho-beta-galactosidase activity
F0T03_RS06980	COG1695	Transcriptional regulator
F0T03_RS06985	COG2824	Alkylphosphonate utilization operon protein PhnA
F0T03_RS06990	COG0583	DNA-binding transcription factor activity
F0T03_RS07015	COG1674	ftsk spoiiie
F0T03_RS07030	COG3423	Transcriptional regulator
F0T03_RS07055	COG2003	Belongs to the UPF0758 family
F0T03_RS07060	COG4974	Belongs to the 'phage' integrase family
F0T03_RS07110	COG2826	transposase and inactivated derivatives, IS30 family
F0T03_RS07120	COG1902	pentaerythritol trinitrate reductase activity
F0T03_RS07125	COG1073	alpha beta
F0T03_RS07145	COG0583	DNA-binding transcription factor activity
F0T03_RS07160	COG0582	viral genome integration into host DNA
F0T03_RS07170	COG2116	formate transmembrane transporter activity
F0T03_RS07180	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0T03_RS07185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0T03_RS07190	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F0T03_RS07195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F0T03_RS07200	COG1138	Cytochrome C-type biogenesis protein
F0T03_RS07205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0T03_RS07215	COG3088	subunit of a heme lyase
F0T03_RS07215	COG4235	cytochrome complex assembly
F0T03_RS07230	COG3691	Protein conserved in bacteria
F0T03_RS07235	COG0183	Belongs to the thiolase family
F0T03_RS07240	COG1024	Enoyl-CoA hydratase
F0T03_RS07240	COG1250	3-hydroxyacyl-CoA dehydrogenase
F0T03_RS07245	COG2062	phosphohistidine phosphatase, SixA
F0T03_RS07250	COG2840	Smr protein MutS2
F0T03_RS07255	COG2890	protein-(glutamine-N5) methyltransferase activity
F0T03_RS07260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F0T03_RS07265	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
F0T03_RS07270	COG0730	response to heat
F0T03_RS07275	COG3101	peptidyl-lysine hydroxylation
F0T03_RS07285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0T03_RS07285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
F0T03_RS07290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0T03_RS07295	COG3706	GGDEF domain
F0T03_RS07295	COG0745	RESPONSE REGULATOR receiver
F0T03_RS07300	COG1794	racemase activity, acting on amino acids and derivatives
F0T03_RS07310	COG1447	Phosphotransferase system cellobiose-specific component IIA
F0T03_RS07315	COG2723	6-phospho-beta-galactosidase activity
F0T03_RS07320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F0T03_RS07330	COG1609	Transcriptional regulator
F0T03_RS07340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0T03_RS07355	COG4232	protein-disulfide reductase activity
F0T03_RS07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0T03_RS07370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0T03_RS07380	COG0697	spore germination
F0T03_RS07390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0T03_RS07395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0T03_RS07405	COG0586	Pfam SNARE associated Golgi protein
F0T03_RS07410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F0T03_RS07415	COG0285	dihydrofolate synthase activity
F0T03_RS07420	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
F0T03_RS07425	COG1286	toxin biosynthetic process
F0T03_RS07430	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F0T03_RS07435	COG0163	prenyltransferase activity
F0T03_RS07440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS07445	COG4215	(ABC) transporter
F0T03_RS07450	COG4160	amino acid transport
F0T03_RS07455	COG4598	ABC transporter
F0T03_RS07460	COG1090	epimerase
F0T03_RS07470	COG0622	Phosphoesterase
F0T03_RS07475	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
F0T03_RS07480	COG3037	sugar-specific permease SgaT UlaA
F0T03_RS07490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS07495	COG1609	Transcriptional regulator
F0T03_RS07500	COG0857	belongs to the CobB CobQ family
F0T03_RS07500	COG0280	phosphate acetyltransferase
F0T03_RS07510	COG3092	negative regulation of chromosome organization
F0T03_RS07515	COG3013	Belongs to the UPF0304 family
F0T03_RS07520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0T03_RS07530	COG0490	domain, Protein
F0T03_RS07530	COG0471	metal ion transport
F0T03_RS07535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0T03_RS07540	COG0436	Aminotransferase
F0T03_RS07545	COG0583	DNA-binding transcription factor activity
F0T03_RS07550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS07555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS07560	COG0649	NAD binding
F0T03_RS07560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS07565	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F0T03_RS07570	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F0T03_RS07575	COG1034	ATP synthesis coupled electron transport
F0T03_RS07580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F0T03_RS07585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS07590	COG0839	Belongs to the complex I subunit 6 family
F0T03_RS07595	COG0713	ATP synthesis coupled electron transport
F0T03_RS07600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0T03_RS07605	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS07610	COG1007	ATP synthesis coupled electron transport
F0T03_RS07640	COG3265	gluconokinase activity
F0T03_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS07650	COG1609	Transcriptional regulator
F0T03_RS07655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0T03_RS07665	COG4702	Belongs to the UPF0303 family
F0T03_RS07670	COG0129	dihydroxy-acid dehydratase activity
F0T03_RS07675	COG4575	ribosome binding
F0T03_RS07680	COG1169	isochorismate synthase
F0T03_RS07685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F0T03_RS07690	COG0596	Alpha beta hydrolase
F0T03_RS07695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F0T03_RS07700	COG1441	menaquinone biosynthetic process
F0T03_RS07720	COG0814	amino acid
F0T03_RS07730	COG4574	serine-type endopeptidase inhibitor activity
F0T03_RS07735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0T03_RS07745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F0T03_RS07750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0T03_RS07760	COG2205	protein histidine kinase activity
F0T03_RS07760	COG0784	Response regulator, receiver
F0T03_RS07770	COG2198	Histidine kinase
F0T03_RS07770	COG0642	Histidine kinase
F0T03_RS07775	COG2223	nitrite transmembrane transporter activity
F0T03_RS07780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
F0T03_RS07795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F0T03_RS07840	COG2190	(PTS) system
F0T03_RS07840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS07840	COG1263	PTS System
F0T03_RS07845	COG2723	6-phospho-beta-galactosidase activity
F0T03_RS07850	COG3338	carbonate dehydratase activity
F0T03_RS07895	COG3082	Protein of unknown function (DUF1414)
F0T03_RS07900	COG3081	Nucleoid-associated protein
F0T03_RS07910	COG1061	Type III restriction enzyme res subunit
F0T03_RS07915	COG1187	pseudouridine synthase activity
F0T03_RS07920	COG2814	Major facilitator Superfamily
F0T03_RS07930	COG4172	Belongs to the ABC transporter superfamily
F0T03_RS07935	COG4239	(ABC) transporter, permease
F0T03_RS07940	COG4174	ABC transporter (Permease)
F0T03_RS07945	COG4166	transmembrane transport
F0T03_RS07950	COG2200	EAL domain
F0T03_RS07955	COG0791	NLP P60 protein
F0T03_RS07960	COG0671	phosphoesterase, PA-phosphatase related
F0T03_RS07965	COG0523	cobalamin synthesis protein
F0T03_RS07975	COG2186	Transcriptional regulator
F0T03_RS07980	COG0246	Mannitol dehydrogenase
F0T03_RS07985	COG1312	Catalyzes the dehydration of D-mannonate
F0T03_RS07990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F0T03_RS08005	COG0243	molybdopterin cofactor binding
F0T03_RS08010	COG3005	denitrification pathway
F0T03_RS08025	COG1105	Belongs to the carbohydrate kinase PfkB family
F0T03_RS08030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0T03_RS08030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F0T03_RS08030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
F0T03_RS08035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F0T03_RS08040	COG2855	membrane
F0T03_RS08055	COG0583	DNA-binding transcription factor activity
F0T03_RS08060	COG0833	amino acid
F0T03_RS08065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0T03_RS08075	COG4771	TonB-dependent receptor
F0T03_RS08080	COG0625	glutathione transferase activity
F0T03_RS08105	COG2011	ABC-type metal ion transport system permease component
F0T03_RS08110	COG0626	cystathionine gamma-synthase activity
F0T03_RS08120	COG1686	Belongs to the peptidase S11 family
F0T03_RS08125	COG1760	l-serine dehydratase
F0T03_RS08130	COG0814	amino acid
F0T03_RS08135	COG1349	DNA-binding transcription factor activity
F0T03_RS08140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F0T03_RS08145	COG0671	phosphoesterase, PA-phosphatase related
F0T03_RS08155	COG2985	domain, Protein
F0T03_RS08155	COG0569	domain protein
F0T03_RS08160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F0T03_RS08175	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
F0T03_RS08180	COG3842	ATPase activity
F0T03_RS08185	COG1176	ABC-type spermidine putrescine transport system, permease component I
F0T03_RS08190	COG1177	transmembrane transport
F0T03_RS08200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F0T03_RS08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS08210	COG4160	amino acid transport
F0T03_RS08215	COG4215	(ABC) transporter
F0T03_RS08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS08225	COG1126	abc transporter atp-binding protein
F0T03_RS08240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0T03_RS08245	COG0702	epimerase
F0T03_RS08250	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
F0T03_RS08255	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F0T03_RS08260	COG0028	Belongs to the TPP enzyme family
F0T03_RS08265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0T03_RS08270	COG1151	hydroxylamine reductase activity
F0T03_RS08275	COG2431	L-lysine efflux transmembrane transporter activity
F0T03_RS08280	COG3593	DNA synthesis involved in DNA repair
F0T03_RS08285	COG2990	Protein conserved in bacteria
F0T03_RS08290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS08300	COG1278	Cold shock
F0T03_RS08305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
F0T03_RS08310	COG0542	response to heat
F0T03_RS08315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F0T03_RS08320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F0T03_RS08325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F0T03_RS08335	COG0492	ferredoxin-NADP+ reductase activity
F0T03_RS08345	COG3107	peptidoglycan biosynthetic process
F0T03_RS08345	COG1674	ftsk spoiiie
F0T03_RS08350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F0T03_RS08355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F0T03_RS08360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F0T03_RS08365	COG2814	Major facilitator Superfamily
F0T03_RS08370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F0T03_RS08375	COG1882	Formate acetyltransferase
F0T03_RS08380	COG2116	formate transmembrane transporter activity
F0T03_RS08385	COG1944	ATP diphosphatase activity
F0T03_RS08390	COG0252	asparaginase activity
F0T03_RS08400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F0T03_RS08405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F0T03_RS08410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F0T03_RS08415	COG0539	negative regulation of cytoplasmic translation
F0T03_RS08420	COG0776	regulation of translation
F0T03_RS08425	COG2333	competence protein COMEC
F0T03_RS08425	COG0658	competence protein
F0T03_RS08435	COG1663	tetraacyldisaccharide 4'-kinase activity
F0T03_RS08440	COG5383	Protein conserved in bacteria
F0T03_RS08445	COG1278	Cold shock
F0T03_RS08450	COG2835	tetraacyldisaccharide 4'-kinase activity
F0T03_RS08460	COG3173	Aminoglycoside phosphotransferase
F0T03_RS08465	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F0T03_RS08470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0T03_RS08475	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
F0T03_RS08480	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
F0T03_RS08485	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F0T03_RS08490	COG2989	Protein conserved in bacteria
F0T03_RS08495	COG3108	Peptidase M15
F0T03_RS08500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F0T03_RS08505	COG2200	EAL domain
F0T03_RS08510	COG1448	Aminotransferase
F0T03_RS08525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F0T03_RS08530	COG0308	aminopeptidase N
F0T03_RS08535	COG0167	dihydroorotate dehydrogenase activity
F0T03_RS08545	COG3217	Mosc domain protein beta barrel domain protein
F0T03_RS08545	COG0633	Ferredoxin
F0T03_RS08550	COG0116	Belongs to the methyltransferase superfamily
F0T03_RS08550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0T03_RS08555	COG0488	(ABC) transporter
F0T03_RS08560	COG2995	paraquat-inducible protein a
F0T03_RS08565	COG3008	intermembrane lipid transfer
F0T03_RS08565	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0T03_RS08570	COG3009	Protein conserved in bacteria
F0T03_RS08575	COG3130	regulation of translation
F0T03_RS08580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0T03_RS08590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0T03_RS08595	COG1067	ATP-dependent peptidase activity
F0T03_RS08600	COG3120	sequence-specific DNA binding
F0T03_RS08605	COG2885	chlorophyll binding
F0T03_RS08605	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F0T03_RS08610	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
F0T03_RS08615	COG3070	regulator of competence-specific genes
F0T03_RS08620	COG1289	transmembrane transporter activity
F0T03_RS08625	COG3304	Inner membrane component domain
F0T03_RS08630	COG0210	DNA helicase
F0T03_RS08640	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
F0T03_RS08645	COG1832	CoA-binding protein
F0T03_RS08650	COG3785	DNA binding
F0T03_RS08655	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F0T03_RS08670	COG1254	Belongs to the acylphosphatase family
F0T03_RS08675	COG2920	part of a sulfur-relay system
F0T03_RS08690	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
F0T03_RS08695	COG0437	4 iron, 4 sulfur cluster binding
F0T03_RS08700	COG3301	Polysulphide reductase, NrfD
F0T03_RS08705	COG1138	Cytochrome C-type biogenesis protein
F0T03_RS08710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F0T03_RS08715	COG4235	cytochrome complex assembly
F0T03_RS08715	COG3088	subunit of a heme lyase
F0T03_RS08725	COG2771	luxR family
F0T03_RS08730	COG3916	Acyl-homoserine-lactone synthase
F0T03_RS08740	COG3263	regulation of cellular component size
F0T03_RS08755	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F0T03_RS08760	COG2943	transferase activity, transferring hexosyl groups
F0T03_RS08765	COG5645	(Lipo)protein
F0T03_RS08780	COG3104	oligopeptide transport
F0T03_RS08785	COG2814	Major facilitator Superfamily
F0T03_RS08790	COG2259	Doxx family
F0T03_RS08795	COG1560	Kdo2-lipid A biosynthetic process
F0T03_RS08830	COG0628	permease
F0T03_RS08860	COG0418	dihydroorotase activity
F0T03_RS08865	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F0T03_RS08870	COG1530	ribonuclease E activity
F0T03_RS08875	COG0564	pseudouridine synthase activity
F0T03_RS08885	COG1399	metal-binding, possibly nucleic acid-binding protein
F0T03_RS08890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F0T03_RS08895	COG0416	fatty acid biosynthetic process
F0T03_RS08905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F0T03_RS08910	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS08920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F0T03_RS08925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F0T03_RS08930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F0T03_RS08935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F0T03_RS08940	COG0470	DNA polymerase III
F0T03_RS08945	COG0084	hydrolase, TatD family'
F0T03_RS08950	COG1263	PTS System
F0T03_RS08950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS08960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0T03_RS08965	COG0537	adenosine 5'-monophosphoramidase activity
F0T03_RS08970	COG5633	Lipoprotein
F0T03_RS08975	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
F0T03_RS08980	COG0510	thiamine kinase activity
F0T03_RS08990	COG3150	esterase
F0T03_RS08995	COG1252	NADH dehydrogenase
F0T03_RS09000	COG3134	Outer membrane lipoprotein
F0T03_RS09005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F0T03_RS09010	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0T03_RS09020	COG4591	ABC-type transport system involved in lipoprotein release permease component
F0T03_RS09025	COG1940	carbohydrate kinase activity
F0T03_RS09030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F0T03_RS09040	COG2850	peptidyl-arginine hydroxylation
F0T03_RS09050	COG0745	RESPONSE REGULATOR receiver
F0T03_RS09060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F0T03_RS09065	COG2915	High frequency lysogenization protein hflD homolog
F0T03_RS09070	COG0482	sulfurtransferase activity
F0T03_RS09080	COG1187	pseudouridine synthase activity
F0T03_RS09085	COG0538	isocitrate dehydrogenase activity
F0T03_RS09090	COG0582	viral genome integration into host DNA
F0T03_RS09110	COG2814	Major facilitator Superfamily
F0T03_RS09130	COG2826	transposase and inactivated derivatives, IS30 family
F0T03_RS09170	COG0538	isocitrate dehydrogenase activity
F0T03_RS09205	COG0840	transmembrane signaling receptor activity
F0T03_RS09215	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0T03_RS09225	COG2873	o-acetylhomoserine
F0T03_RS09230	COG0702	epimerase
F0T03_RS09235	COG1733	regulation of RNA biosynthetic process
F0T03_RS09255	COG3755	Protein conserved in bacteria
F0T03_RS09265	COG2203	Gaf domain
F0T03_RS09265	COG4251	negative regulation of phosphorylation
F0T03_RS09265	COG5001	Diguanylate cyclase
F0T03_RS09265	COG3706	GGDEF domain
F0T03_RS09275	COG1132	(ABC) transporter
F0T03_RS09295	COG2207	Transcriptional regulator
F0T03_RS09330	COG1113	amino acid transport
F0T03_RS09345	COG1278	Cold shock
F0T03_RS09355	COG0768	penicillin binding
F0T03_RS09360	COG2226	methyltransferase
F0T03_RS09370	COG3447	MASE1 domain protein
F0T03_RS09370	COG5001	Diguanylate cyclase
F0T03_RS09370	COG5002	protein histidine kinase activity
F0T03_RS09380	COG1971	Probably functions as a manganese efflux pump
F0T03_RS09385	COG4811	Protein of unknown function (DUF986)
F0T03_RS09390	COG3716	PTS system mannose fructose sorbose family IID component
F0T03_RS09395	COG3715	PTS system
F0T03_RS09400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS09400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS09405	COG1253	flavin adenine dinucleotide binding
F0T03_RS09415	COG1760	l-serine dehydratase
F0T03_RS09420	COG0494	nUDIX hydrolase
F0T03_RS09430	COG3140	Belongs to the UPF0181 family
F0T03_RS09435	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F0T03_RS09440	COG0513	Belongs to the DEAD box helicase family
F0T03_RS09445	COG3141	response to X-ray
F0T03_RS09460	COG1770	oligopeptidase
F0T03_RS09465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0T03_RS09480	COG1528	Iron-storage protein
F0T03_RS09485	COG2372	response to copper ion
F0T03_RS09490	COG1276	copper resistance
F0T03_RS09555	COG0668	transmembrane transport
F0T03_RS09565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F0T03_RS09570	COG0589	response to stress
F0T03_RS09585	COG1187	pseudouridine synthase activity
F0T03_RS09605	COG0625	glutathione transferase activity
F0T03_RS09625	COG5001	Diguanylate cyclase
F0T03_RS09625	COG3706	GGDEF domain
F0T03_RS09625	COG4251	negative regulation of phosphorylation
F0T03_RS09625	COG2203	Gaf domain
F0T03_RS09670	COG3008	intermembrane lipid transfer
F0T03_RS09675	COG2995	paraquat-inducible protein a
F0T03_RS09680	COG1956	GAF domain-containing protein
F0T03_RS09690	COG0793	Belongs to the peptidase S41A family
F0T03_RS09695	COG0501	Belongs to the peptidase M48B family
F0T03_RS09700	COG2814	Major facilitator Superfamily
F0T03_RS09705	COG0823	Involved in the tonB-independent uptake of proteins
F0T03_RS09715	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0T03_RS09725	COG1988	membrane-bound metal-dependent
F0T03_RS09730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0T03_RS09735	COG1653	transport
F0T03_RS09740	COG3842	ATPase activity
F0T03_RS09745	COG0395	ABC-type sugar transport system, permease component
F0T03_RS09750	COG1175	transmembrane transport
F0T03_RS09760	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS09765	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F0T03_RS09770	COG1917	Cupin 2, conserved barrel domain protein
F0T03_RS09775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0T03_RS09785	COG0583	DNA-binding transcription factor activity
F0T03_RS09790	COG0427	acetyl-CoA hydrolase
F0T03_RS09795	COG1024	Enoyl-CoA hydratase
F0T03_RS09800	COG1703	isobutyryl-CoA mutase activity
F0T03_RS09805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0T03_RS09805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0T03_RS09815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0T03_RS09820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0T03_RS09825	COG1121	(ABC) transporter
F0T03_RS09830	COG0803	Belongs to the bacterial solute-binding protein 9 family
F0T03_RS09865	COG1811	Na channel or pump
F0T03_RS09875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F0T03_RS09880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F0T03_RS09885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F0T03_RS09890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F0T03_RS09910	COG0776	regulation of translation
F0T03_RS09920	COG4139	cobalamin transport
F0T03_RS09925	COG0386	Belongs to the glutathione peroxidase family
F0T03_RS09930	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
F0T03_RS09935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F0T03_RS09940	COG0463	Glycosyl transferase, family 2
F0T03_RS09945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0T03_RS09945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0T03_RS09950	COG0726	polysaccharide deacetylase
F0T03_RS09955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F0T03_RS09960	COG2076	Multidrug Resistance protein
F0T03_RS09965	COG2076	Multidrug Resistance protein
F0T03_RS09970	COG0791	NLP P60 protein
F0T03_RS09975	COG0095	Lipoate-protein ligase
F0T03_RS09985	COG4558	Periplasmic binding protein
F0T03_RS09990	COG3720	iron ion transport
F0T03_RS10010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F0T03_RS10015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F0T03_RS10015	COG0574	Belongs to the PEP-utilizing enzyme family
F0T03_RS10025	COG0628	permease
F0T03_RS10030	COG0277	FAD linked oxidase domain protein
F0T03_RS10030	COG0247	lactate metabolic process
F0T03_RS10035	COG2050	protein possibly involved in aromatic compounds catabolism
F0T03_RS10040	COG0316	Belongs to the HesB IscA family
F0T03_RS10045	COG0719	Fe-S assembly protein
F0T03_RS10050	COG0396	ATPase activity
F0T03_RS10055	COG0719	Fe-S assembly protein
F0T03_RS10065	COG2166	iron-sulfur cluster assembly
F0T03_RS10070	COG1376	ErfK ybiS ycfS ynhG family protein
F0T03_RS10070	COG1388	LysM domain
F0T03_RS10075	COG4238	major outer membrane lipoprotein
F0T03_RS10100	COG0534	Mate efflux family protein
F0T03_RS10105	COG0307	riboflavin synthase, alpha
F0T03_RS10110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F0T03_RS10115	COG2814	Major facilitator Superfamily
F0T03_RS10120	COG0583	DNA-binding transcription factor activity
F0T03_RS10125	COG1609	Transcriptional regulator
F0T03_RS10135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0T03_RS10140	COG0791	NLP P60 protein
F0T03_RS10145	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F0T03_RS10150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F0T03_RS10155	COG0346	lactoylglutathione lyase activity
F0T03_RS10165	COG1902	pentaerythritol trinitrate reductase activity
F0T03_RS10170	COG1309	transcriptional regulator
F0T03_RS10175	COG2194	sulfuric ester hydrolase activity
F0T03_RS10180	COG3313	Fe-S protein
F0T03_RS10185	COG4989	oxidoreductase activity
F0T03_RS10195	COG1566	PFAM secretion protein HlyD family protein
F0T03_RS10205	COG1846	Transcriptional regulator
F0T03_RS10210	COG3133	Outer membrane lipoprotein
F0T03_RS10215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F0T03_RS10220	COG3895	Periplasmic Protein
F0T03_RS10230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F0T03_RS10240	COG0625	glutathione transferase activity
F0T03_RS10260	COG3104	oligopeptide transport
F0T03_RS10270	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0T03_RS10270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F0T03_RS10280	COG4172	Belongs to the ABC transporter superfamily
F0T03_RS10290	COG4171	peptide transport system, permease
F0T03_RS10295	COG4168	peptide transport system, permease
F0T03_RS10300	COG4166	transmembrane transport
F0T03_RS10315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F0T03_RS10320	COG1842	Phage shock protein A
F0T03_RS10330	COG1983	PspC domain protein
F0T03_RS10340	COG3106	COG3106 Predicted ATPase
F0T03_RS10345	COG3768	UPF0283 membrane protein
F0T03_RS10365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F0T03_RS10370	COG4948	Mandelate Racemase Muconate Lactonizing
F0T03_RS10375	COG2866	Carboxypeptidase
F0T03_RS10380	COG4166	transmembrane transport
F0T03_RS10390	COG0598	Magnesium transport protein CorA
F0T03_RS10395	COG0037	tRNA processing
F0T03_RS10400	COG0823	Involved in the tonB-independent uptake of proteins
F0T03_RS10410	COG0674	pyruvate-flavodoxin oxidoreductase activity
F0T03_RS10410	COG1013	pyruvate-flavodoxin oxidoreductase activity
F0T03_RS10410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F0T03_RS10410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS10420	COG1285	pathogenesis
F0T03_RS10430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F0T03_RS10435	COG2911	Protein conserved in bacteria
F0T03_RS10445	COG3784	Protein of unknown function (DUF1318)
F0T03_RS10450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F0T03_RS10460	COG1643	Atp-dependent helicase
F0T03_RS10465	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
F0T03_RS10475	COG3591	Belongs to the peptidase S1B family
F0T03_RS10485	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F0T03_RS10490	COG2205	protein histidine kinase activity
F0T03_RS10495	COG0745	RESPONSE REGULATOR receiver
F0T03_RS10505	COG0531	amino acid
F0T03_RS10515	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
F0T03_RS10520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
F0T03_RS10525	COG0589	response to stress
F0T03_RS10530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F0T03_RS10535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F0T03_RS10550	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
F0T03_RS10555	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS10565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0T03_RS10570	COG0738	Major facilitator superfamily
F0T03_RS10585	COG0583	DNA-binding transcription factor activity
F0T03_RS10595	COG1011	Hydrolase
F0T03_RS10600	COG0440	acetolactate synthase activity
F0T03_RS10605	COG0028	Belongs to the TPP enzyme family
F0T03_RS10620	COG3023	N-Acetylmuramoyl-L-alanine amidase
F0T03_RS10640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F0T03_RS10655	COG4215	(ABC) transporter
F0T03_RS10665	COG1522	sequence-specific DNA binding
F0T03_RS10680	COG1773	rubredoxin
F0T03_RS10680	COG0426	domain, Protein
F0T03_RS10685	COG3604	Transcriptional regulator
F0T03_RS10690	COG0625	glutathione transferase activity
F0T03_RS10710	COG0477	Major facilitator Superfamily
F0T03_RS10715	COG4221	oxidoreductase activity
F0T03_RS10720	COG1742	UPF0060 membrane protein
F0T03_RS10740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0T03_RS10745	COG1940	carbohydrate kinase activity
F0T03_RS10750	COG0583	DNA-binding transcription factor activity
F0T03_RS10755	COG2814	Major facilitator Superfamily
F0T03_RS10775	COG0114	fumarate hydratase activity
F0T03_RS10785	COG5339	Protein conserved in bacteria
F0T03_RS10790	COG1609	Transcriptional regulator
F0T03_RS10795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS10795	COG1263	PTS System
F0T03_RS10800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F0T03_RS10805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F0T03_RS10810	COG0385	Bile acid
F0T03_RS10815	COG0673	inositol 2-dehydrogenase activity
F0T03_RS10825	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS10835	COG1879	ABC-type sugar transport system periplasmic component
F0T03_RS10845	COG2160	L-arabinose isomerase activity
F0T03_RS10860	COG2274	protein secretion by the type I secretion system
F0T03_RS10865	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F0T03_RS10875	COG4657	Part of a membrane complex involved in electron transport
F0T03_RS10885	COG4656	Part of a membrane complex involved in electron transport
F0T03_RS10890	COG3708	Transcriptional regulator
F0T03_RS10890	COG2207	Transcriptional regulator
F0T03_RS10895	COG4658	electron transport chain
F0T03_RS10900	COG4659	FMN binding
F0T03_RS10910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F0T03_RS10930	COG0243	molybdopterin cofactor binding
F0T03_RS10935	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
F0T03_RS10940	COG1966	Carbon starvation protein
F0T03_RS10945	COG2879	small protein
F0T03_RS10950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F0T03_RS10955	COG1349	DNA-binding transcription factor activity
F0T03_RS10975	COG0023	Translation Initiation Factor
F0T03_RS10980	COG0284	orotidine-5'-phosphate decarboxylase activity
F0T03_RS10990	COG3135	benzoate transporter
F0T03_RS10995	COG1396	sequence-specific DNA binding
F0T03_RS11005	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
F0T03_RS11010	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
F0T03_RS11015	COG0671	phosphoesterase, PA-phosphatase related
F0T03_RS11020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0T03_RS11025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F0T03_RS11040	COG0583	DNA-binding transcription factor activity
F0T03_RS11045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0T03_RS11055	COG0616	signal peptide processing
F0T03_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS11065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F0T03_RS11070	COG1187	pseudouridine synthase activity
F0T03_RS11075	COG2197	response regulator
F0T03_RS11090	COG1388	LysM domain
F0T03_RS11090	COG2373	Large extracellular alpha-helical protein
F0T03_RS11090	COG4932	domain protein
F0T03_RS11110	COG0009	L-threonylcarbamoyladenylate synthase
F0T03_RS11115	COG0613	PHP domain protein
F0T03_RS11130	COG0512	Glutamine amidotransferase of anthranilate synthase
F0T03_RS11140	COG0135	phosphoribosylanthranilate isomerase activity
F0T03_RS11140	COG0134	indole-3-glycerol-phosphate synthase activity
F0T03_RS11145	COG0133	tryptophan synthase activity
F0T03_RS11150	COG0159	tryptophan synthase activity
F0T03_RS11160	COG3047	cAMP biosynthetic process
F0T03_RS11180	COG2917	probably involved in intracellular septation
F0T03_RS11185	COG1607	acyl-coa hydrolase
F0T03_RS11190	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
F0T03_RS11195	COG2350	Protein conserved in bacteria
F0T03_RS11220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0T03_RS11235	COG0444	Belongs to the ABC transporter superfamily
F0T03_RS11240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0T03_RS11255	COG2095	MarC family integral membrane protein
F0T03_RS11260	COG1454	alcohol dehydrogenase
F0T03_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
F0T03_RS11265	COG1435	thymidine kinase activity
F0T03_RS11270	COG2916	Histone family protein nucleoid-structuring protein H-NS
F0T03_RS11280	COG0745	RESPONSE REGULATOR receiver
F0T03_RS11285	COG1752	Esterase of the alpha-beta hydrolase superfamily
F0T03_RS11290	COG3012	SEC-C Motif Domain Protein
F0T03_RS11295	COG0788	formyltetrahydrofolate deformylase activity
F0T03_RS11310	COG0583	DNA-binding transcription factor activity
F0T03_RS11315	COG0708	Exodeoxyribonuclease III
F0T03_RS11320	COG0494	nUDIX hydrolase
F0T03_RS11330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F0T03_RS11340	COG0778	Nitroreductase
F0T03_RS11345	COG0616	signal peptide processing
F0T03_RS11350	COG0252	asparaginase activity
F0T03_RS11355	COG3139	Protein of unknown function (DUF1315)
F0T03_RS11375	COG3713	MltA-interacting MipA family protein
F0T03_RS11380	COG2766	serine protein kinase
F0T03_RS11385	COG2718	Belongs to the UPF0229 family
F0T03_RS11400	COG0583	DNA-binding transcription factor activity
F0T03_RS11410	COG2199	diguanylate cyclase activity
F0T03_RS11410	COG2202	Pas domain
F0T03_RS11410	COG2200	EAL domain
F0T03_RS11415	COG2814	Major facilitator Superfamily
F0T03_RS11420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0T03_RS11425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F0T03_RS11430	COG2719	SpoVR family
F0T03_RS11435	COG2186	Transcriptional regulator
F0T03_RS11440	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F0T03_RS11445	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F0T03_RS11455	COG2983	Belongs to the UPF0260 family
F0T03_RS11460	COG0179	Fumarylacetoacetate (FAA) hydrolase
F0T03_RS11465	COG2951	lytic endotransglycosylase activity
F0T03_RS11470	COG3100	YcgL domain-containing protein
F0T03_RS11480	COG0850	regulation of cytokinetic process
F0T03_RS11485	COG2894	cell division
F0T03_RS11490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
F0T03_RS11495	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F0T03_RS11500	COG0318	PFAM AMP-dependent synthetase and ligase
F0T03_RS11505	COG3065	identical protein binding
F0T03_RS11515	COG1199	ATP-dependent helicase activity
F0T03_RS11520	COG0251	oxidation-reduction process
F0T03_RS11525	COG2076	Multidrug Resistance protein
F0T03_RS11530	COG2076	Multidrug Resistance protein
F0T03_RS11535	COG0800	Aldolase
F0T03_RS11540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F0T03_RS11545	COG1737	Transcriptional regulator
F0T03_RS11550	COG0469	pyruvate kinase activity
F0T03_RS11555	COG1560	Kdo2-lipid A biosynthetic process
F0T03_RS11560	COG0739	heme binding
F0T03_RS11565	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
F0T03_RS11570	COG1121	(ABC) transporter
F0T03_RS11575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0T03_RS11580	COG3104	oligopeptide transport
F0T03_RS11585	COG2255	four-way junction helicase activity
F0T03_RS11590	COG0632	four-way junction helicase activity
F0T03_RS11600	COG0217	transcriptional regulatory protein
F0T03_RS11605	COG0494	nUDIX hydrolase
F0T03_RS11610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F0T03_RS11620	COG1335	isochorismatase
F0T03_RS11625	COG1801	Protein of unknown function DUF72
F0T03_RS11630	COG3788	relative of glutathione S-transferase, MAPEG superfamily
F0T03_RS11640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F0T03_RS11645	COG3142	Participates in the control of copper homeostasis
F0T03_RS11650	COG3102	Protein conserved in bacteria
F0T03_RS11655	COG0018	arginyl-trna synthetase
F0T03_RS11660	COG0728	peptidoglycan biosynthetic process
F0T03_RS11665	COG0673	inositol 2-dehydrogenase activity
F0T03_RS11675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0T03_RS11680	COG0477	Major facilitator Superfamily
F0T03_RS11690	COG3381	protein complex oligomerization
F0T03_RS11695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F0T03_RS11700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0T03_RS11720	COG3706	GGDEF domain
F0T03_RS11725	COG0659	secondary active sulfate transmembrane transporter activity
F0T03_RS11730	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F0T03_RS11735	COG2912	Transglutaminase-like superfamily
F0T03_RS11740	COG3094	Invasion gene expression up-regulator, SirB
F0T03_RS11745	COG2890	protein-(glutamine-N5) methyltransferase activity
F0T03_RS11750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F0T03_RS11755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F0T03_RS11760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
F0T03_RS11770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F0T03_RS11780	COG0193	aminoacyl-tRNA hydrolase activity
F0T03_RS11790	COG0012	GTP binding
F0T03_RS11795	COG0582	viral genome integration into host DNA
F0T03_RS11800	COG2267	carboxylic ester hydrolase activity
F0T03_RS11805	COG0583	DNA-binding transcription factor activity
F0T03_RS11815	COG0582	viral genome integration into host DNA
F0T03_RS11900	COG2003	Belongs to the UPF0758 family
F0T03_RS11925	COG3423	Transcriptional regulator
F0T03_RS11965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS11970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS12005	COG0640	Transcriptional regulator
F0T03_RS12010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F0T03_RS12015	COG1393	Belongs to the ArsC family
F0T03_RS12025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS12030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS12035	COG0745	RESPONSE REGULATOR receiver
F0T03_RS12040	COG2205	protein histidine kinase activity
F0T03_RS12050	COG1349	DNA-binding transcription factor activity
F0T03_RS12060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS12070	COG3716	PTS system mannose fructose sorbose family IID component
F0T03_RS12075	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS12080	COG2222	sugar isomerase
F0T03_RS12090	COG4942	peptidase
F0T03_RS12100	COG3443	Belongs to the bacterial solute-binding protein 9 family
F0T03_RS12105	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS12110	COG1129	ABC transporter
F0T03_RS12125	COG0402	S-adenosylhomocysteine deaminase activity
F0T03_RS12135	COG1228	amidohydrolase
F0T03_RS12150	COG2988	succinylglutamate desuccinylase activity
F0T03_RS12155	COG3724	N-succinylarginine dihydrolase activity
F0T03_RS12165	COG3138	arginine N-succinyltransferase
F0T03_RS12170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F0T03_RS12175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0T03_RS12180	COG1271	oxidase subunit
F0T03_RS12185	COG1294	oxidase, subunit
F0T03_RS12195	COG3850	Histidine kinase
F0T03_RS12200	COG0583	DNA-binding transcription factor activity
F0T03_RS12205	COG2814	Major facilitator Superfamily
F0T03_RS12215	COG0387	Pfam Sodium calcium exchanger
F0T03_RS12220	COG1702	phosphate starvation-inducible protein PhoH
F0T03_RS12230	COG3658	cytochrome
F0T03_RS12235	COG1215	transferase activity, transferring glycosyl groups
F0T03_RS12240	COG1649	PFAM Uncharacterised BCR, COG1649
F0T03_RS12240	COG0726	polysaccharide deacetylase
F0T03_RS12245	COG0457	Tetratricopeptide repeat
F0T03_RS12250	COG0006	proline dipeptidase activity
F0T03_RS12260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F0T03_RS12285	COG0577	efflux transmembrane transporter activity
F0T03_RS12285	COG1136	(ABC) transporter
F0T03_RS12295	COG0577	efflux transmembrane transporter activity
F0T03_RS12295	COG1136	(ABC) transporter
F0T03_RS12310	COG0672	)-iron permease
F0T03_RS12325	COG2066	Belongs to the glutaminase family
F0T03_RS12330	COG3622	Belongs to the hyi family
F0T03_RS12335	COG0235	Class ii aldolase
F0T03_RS12340	COG3395	kinase activity
F0T03_RS12345	COG1349	DNA-binding transcription factor activity
F0T03_RS12350	COG3290	protein histidine kinase activity
F0T03_RS12355	COG4565	transcriptional regulatory protein
F0T03_RS12360	COG3493	citrate carrier protein
F0T03_RS12375	COG0346	lactoylglutathione lyase activity
F0T03_RS12385	COG2223	nitrite transmembrane transporter activity
F0T03_RS12390	COG0561	phosphatase activity
F0T03_RS12395	COG0488	(ABC) transporter
F0T03_RS12405	COG3122	Protein conserved in bacteria
F0T03_RS12470	COG0251	oxidation-reduction process
F0T03_RS12480	COG3772	lysozyme
F0T03_RS12515	COG2801	Transposase and inactivated derivatives
F0T03_RS12530	COG2826	transposase and inactivated derivatives, IS30 family
F0T03_RS12545	COG1403	HNH endonuclease
F0T03_RS12610	COG5532	Uncharacterized conserved protein (DUF2303)
F0T03_RS12615	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F0T03_RS12665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0T03_RS12670	COG0322	excinuclease ABC activity
F0T03_RS12675	COG2197	response regulator
F0T03_RS12685	COG3136	membrane protein required for alginate biosynthesis
F0T03_RS12710	COG2226	methyltransferase
F0T03_RS12730	COG1113	amino acid transport
F0T03_RS12740	COG1881	PFAM PEBP family protein
F0T03_RS12745	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F0T03_RS12755	COG0655	NAD(P)H dehydrogenase (quinone) activity
F0T03_RS12780	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F0T03_RS12780	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F0T03_RS12780	COG0506	proline dehydrogenase activity
F0T03_RS12810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
F0T03_RS12820	COG1191	sigma factor activity
F0T03_RS12850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
F0T03_RS12865	COG1677	Flagellar hook-basal body complex protein FliE
F0T03_RS12875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F0T03_RS12880	COG1317	bacterial-type flagellum organization
F0T03_RS12885	COG1157	protein secretion by the type III secretion system
F0T03_RS12890	COG2882	bacterial-type flagellum organization
F0T03_RS12900	COG1580	Controls the rotational direction of flagella during chemotaxis
F0T03_RS12920	COG1338	Plays a role in the flagellum-specific transport system
F0T03_RS12930	COG1684	flagellar biosynthetic protein fliR
F0T03_RS12940	COG1256	bacterial-type flagellum assembly
F0T03_RS12960	COG4786	Flagellar basal body rod
F0T03_RS12970	COG1749	Flagellar hook protein flgE
F0T03_RS12975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F0T03_RS12980	COG1558	bacterial-type flagellum-dependent cell motility
F0T03_RS12985	COG1815	bacterial-type flagellum-dependent cell motility
F0T03_RS12995	COG2747	anti-sigma28 factor FlgM
F0T03_RS13000	COG3418	PFAM FlgN family protein
F0T03_RS13010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F0T03_RS13015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F0T03_RS13020	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
F0T03_RS13025	COG0745	RESPONSE REGULATOR receiver
F0T03_RS13035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F0T03_RS13040	COG0840	transmembrane signaling receptor activity
F0T03_RS13045	COG0840	transmembrane signaling receptor activity
F0T03_RS13050	COG0835	chemotaxis
F0T03_RS13055	COG2198	Histidine kinase
F0T03_RS13055	COG0643	Histidine kinase
F0T03_RS13060	COG1360	Flagellar Motor Protein
F0T03_RS13080	COG0589	response to stress
F0T03_RS13085	COG2130	NADP-dependent
F0T03_RS13095	COG1285	pathogenesis
F0T03_RS13100	COG0840	transmembrane signaling receptor activity
F0T03_RS13110	COG1278	Cold shock
F0T03_RS13115	COG1609	Transcriptional regulator
F0T03_RS13120	COG3250	beta-galactosidase activity
F0T03_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS13125	COG3321	synthase
F0T03_RS13125	COG0604	alcohol dehydrogenase
F0T03_RS13155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F0T03_RS13165	COG0671	phosphoesterase, PA-phosphatase related
F0T03_RS13165	COG2453	phosphatase
F0T03_RS13170	COG2267	carboxylic ester hydrolase activity
F0T03_RS13180	COG4589	Belongs to the CDS family
F0T03_RS13185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F0T03_RS13190	COG3121	Chaperone
F0T03_RS13205	COG3121	Chaperone
F0T03_RS13215	COG3121	Chaperone
F0T03_RS13240	COG3228	Belongs to the MtfA family
F0T03_RS13250	COG0582	viral genome integration into host DNA
F0T03_RS13260	COG1902	pentaerythritol trinitrate reductase activity
F0T03_RS13275	COG0583	DNA-binding transcription factor activity
F0T03_RS13280	COG0583	DNA-binding transcription factor activity
F0T03_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS13305	COG0583	DNA-binding transcription factor activity
F0T03_RS13320	COG0300	oxidoreductase activity
F0T03_RS13345	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F0T03_RS13355	COG2826	transposase and inactivated derivatives, IS30 family
F0T03_RS13365	COG5290	Psort location Cytoplasmic, score
F0T03_RS13370	COG3547	Transposase (IS116 IS110 IS902 family)
F0T03_RS13375	COG4227	nucleotidyltransferase activity
F0T03_RS13415	COG2315	Protein conserved in bacteria
F0T03_RS13420	COG2814	Major facilitator Superfamily
F0T03_RS13455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F0T03_RS13470	COG0471	metal ion transport
F0T03_RS13485	COG3051	citrate lyase alpha subunit
F0T03_RS13490	COG2301	Belongs to the HpcH HpaI aldolase family
F0T03_RS13495	COG3052	prosthetic group binding
F0T03_RS13500	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
F0T03_RS13505	COG3290	protein histidine kinase activity
F0T03_RS13510	COG4565	transcriptional regulatory protein
F0T03_RS13525	COG2271	Major facilitator Superfamily
F0T03_RS13530	COG1840	ABC-type Fe3 transport system, periplasmic component
F0T03_RS13540	COG3842	ATPase activity
F0T03_RS13555	COG2205	protein histidine kinase activity
F0T03_RS13555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS13565	COG3121	Chaperone
F0T03_RS13570	COG3188	usher protein
F0T03_RS13580	COG3121	Chaperone
F0T03_RS13590	COG4221	oxidoreductase activity
F0T03_RS13605	COG0835	chemotaxis
F0T03_RS13605	COG0784	Response regulator, receiver
F0T03_RS13610	COG1349	DNA-binding transcription factor activity
F0T03_RS13615	COG0561	phosphatase activity
F0T03_RS13620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0T03_RS13630	COG0534	Mate efflux family protein
F0T03_RS13640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F0T03_RS13650	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F0T03_RS13660	COG1492	cobalamin metabolic process
F0T03_RS13710	COG2875	Belongs to the precorrin methyltransferase family
F0T03_RS13720	COG2241	protein methyltransferase activity
F0T03_RS13725	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F0T03_RS13735	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F0T03_RS13755	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
F0T03_RS13790	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
F0T03_RS13820	COG1012	belongs to the aldehyde dehydrogenase family
F0T03_RS13830	COG4656	Part of a membrane complex involved in electron transport
F0T03_RS13840	COG4810	utilization protein
F0T03_RS13850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F0T03_RS13860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0T03_RS13870	COG1879	ABC-type sugar transport system periplasmic component
F0T03_RS13880	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS13895	COG1289	transmembrane transporter activity
F0T03_RS13900	COG3320	Male sterility
F0T03_RS13900	COG1022	Amp-dependent synthetase and ligase
F0T03_RS13905	COG2925	Exonuclease
F0T03_RS13910	COG0531	amino acid
F0T03_RS13920	COG0371	Dehydrogenase
F0T03_RS13925	COG1129	ABC transporter
F0T03_RS13930	COG1172	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS13935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0T03_RS13945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F0T03_RS13955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F0T03_RS13960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0T03_RS13960	COG0131	Imidazoleglycerol-phosphate dehydratase
F0T03_RS13965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F0T03_RS13970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F0T03_RS13975	COG0107	imidazoleglycerol-phosphate synthase activity
F0T03_RS13980	COG0140	phosphoribosyl-ATP diphosphatase activity
F0T03_RS13980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F0T03_RS13985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F0T03_RS13990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0T03_RS13995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F0T03_RS14005	COG0438	transferase activity, transferring glycosyl groups
F0T03_RS14015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F0T03_RS14035	COG3039	Transposase
F0T03_RS14060	COG1253	flavin adenine dinucleotide binding
F0T03_RS14065	COG3069	C4-dicarboxylate transmembrane transporter activity
F0T03_RS14070	COG2982	Protein involved in outer membrane biogenesis
F0T03_RS14080	COG0572	uridine kinase
F0T03_RS14085	COG0489	protein tyrosine kinase activity
F0T03_RS14090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0T03_RS14090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F0T03_RS14110	COG2814	Major facilitator Superfamily
F0T03_RS14115	COG1380	Effector of murein hydrolase LrgA
F0T03_RS14120	COG1346	cytolysis
F0T03_RS14130	COG0281	malic enzyme
F0T03_RS14135	COG2949	membrane
F0T03_RS14140	COG0298	carbon dioxide binding
F0T03_RS14145	COG0375	protein maturation
F0T03_RS14150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0T03_RS14155	COG0651	ATP synthesis coupled electron transport
F0T03_RS14160	COG0650	Formate hydrogenlyase subunit 4
F0T03_RS14165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F0T03_RS14170	COG4237	Hydrogenase 4 membrane
F0T03_RS14175	COG0651	ATP synthesis coupled electron transport
F0T03_RS14180	COG3261	NADH dehydrogenase
F0T03_RS14180	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
F0T03_RS14185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F0T03_RS14190	COG3260	NADH ubiquinone oxidoreductase 20
F0T03_RS14200	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F0T03_RS14205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F0T03_RS14210	COG3383	formate dehydrogenase (NAD+) activity
F0T03_RS14215	COG3604	Transcriptional regulator
F0T03_RS14220	COG2116	formate transmembrane transporter activity
F0T03_RS14240	COG1609	Transcriptional regulator
F0T03_RS14245	COG2311	Membrane
F0T03_RS14250	COG0302	gtp cyclohydrolase
F0T03_RS14255	COG0477	Major facilitator Superfamily
F0T03_RS14260	COG0583	DNA-binding transcription factor activity
F0T03_RS14290	COG0577	efflux transmembrane transporter activity
F0T03_RS14290	COG1136	(ABC) transporter
F0T03_RS14300	COG0477	Major facilitator Superfamily
F0T03_RS14350	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F0T03_RS14435	COG4695	Portal protein
F0T03_RS14500	COG4974	Belongs to the 'phage' integrase family
F0T03_RS14510	COG0303	'Molybdopterin
F0T03_RS14515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0T03_RS14520	COG3397	chitin binding
F0T03_RS14525	COG0488	(ABC) transporter
F0T03_RS14545	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F0T03_RS14560	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
F0T03_RS14575	COG4106	trans-aconitate 2-methyltransferase activity
F0T03_RS14580	COG0783	Belongs to the Dps family
F0T03_RS14585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F0T03_RS14590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS14595	COG0765	amino acid transport
F0T03_RS14600	COG1126	abc transporter atp-binding protein
F0T03_RS14610	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
F0T03_RS14625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F0T03_RS14630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F0T03_RS14650	COG0697	spore germination
F0T03_RS14665	COG1174	glycine betaine transport
F0T03_RS14670	COG1125	glycine betaine transport
F0T03_RS14675	COG1174	glycine betaine transport
F0T03_RS14680	COG1732	Glycine betaine
F0T03_RS14690	COG0673	inositol 2-dehydrogenase activity
F0T03_RS14695	COG2897	thiosulfate sulfurtransferase activity
F0T03_RS14700	COG0410	ABC transporter
F0T03_RS14705	COG0411	ABC transporter
F0T03_RS14715	COG0559	Belongs to the binding-protein-dependent transport system permease family
F0T03_RS14725	COG4807	Protein conserved in bacteria
F0T03_RS14740	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
F0T03_RS14750	COG2261	transglycosylase associated protein
F0T03_RS14760	COG1403	HNH endonuclease
F0T03_RS14770	COG0277	FAD linked oxidase domain protein
F0T03_RS14775	COG1686	Belongs to the peptidase S11 family
F0T03_RS14785	COG2239	Acts as a magnesium transporter
F0T03_RS14790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0T03_RS14795	COG0513	Belongs to the DEAD box helicase family
F0T03_RS14800	COG1309	transcriptional regulator
F0T03_RS14805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS14810	COG1131	(ABC) transporter
F0T03_RS14815	COG0842	Transport permease protein
F0T03_RS14820	COG0842	Transport permease protein
F0T03_RS14825	COG0670	Belongs to the BI1 family
F0T03_RS14830	COG0314	molybdopterin synthase activity
F0T03_RS14835	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F0T03_RS14840	COG0315	cyclic pyranopterin monophosphate synthase activity
F0T03_RS14845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F0T03_RS14850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F0T03_RS14855	COG4628	conserved protein (DUF2132)
F0T03_RS14860	COG0556	nucleotide-excision repair
F0T03_RS14870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
F0T03_RS14875	COG2226	methyltransferase
F0T03_RS14880	COG0156	8-amino-7-oxononanoate synthase activity
F0T03_RS14885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0T03_RS14895	COG2706	6-phosphogluconolactonase activity
F0T03_RS14900	COG0561	phosphatase activity
F0T03_RS14910	COG4149	molybdate abc transporter
F0T03_RS14915	COG0725	ABC transporter, periplasmic molybdate-binding protein
F0T03_RS14925	COG3585	molybdate ion transport
F0T03_RS14925	COG2005	Transcriptional regulator
F0T03_RS14930	COG1119	ATPase activity
F0T03_RS14940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F0T03_RS14945	COG1085	galactose-1-phosphate uridylyltransferase
F0T03_RS14950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F0T03_RS14955	COG2017	converts alpha-aldose to the beta-anomer
F0T03_RS14975	COG0588	phosphoglycerate mutase activity
F0T03_RS14980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
F0T03_RS14985	COG1230	cation diffusion facilitator family transporter
F0T03_RS14995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F0T03_RS15020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
F0T03_RS15025	COG2885	chlorophyll binding
F0T03_RS15030	COG0823	Involved in the tonB-independent uptake of proteins
F0T03_RS15035	COG3064	Membrane
F0T03_RS15035	COG3064	Membrane
F0T03_RS15040	COG0848	biopolymer transport protein
F0T03_RS15045	COG0811	peptide transport
F0T03_RS15050	COG0824	Thioesterase
F0T03_RS15055	COG3790	cyd operon protein YbgE
F0T03_RS15060	COG4890	Cyd operon protein YbgT
F0T03_RS15065	COG1294	oxidase, subunit
F0T03_RS15070	COG1271	oxidase subunit
F0T03_RS15075	COG0737	Belongs to the 5'-nucleotidase family
F0T03_RS15085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F0T03_RS15095	COG0508	dehydrogenase complex catalyzes the overall conversion of
F0T03_RS15100	COG0567	Dehydrogenase, E1 component
F0T03_RS15110	COG1053	succinate dehydrogenase
F0T03_RS15115	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
F0T03_RS15120	COG2009	succinate dehydrogenase
F0T03_RS15130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F0T03_RS15145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F0T03_RS15150	COG1984	allophanate hydrolase subunit 2
F0T03_RS15155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F0T03_RS15160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F0T03_RS15165	COG5212	phosphodiesterase
F0T03_RS15175	COG3272	Protein of unknown function (DUF1722)
F0T03_RS15190	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F0T03_RS15195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F0T03_RS15200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F0T03_RS15205	COG2205	protein histidine kinase activity
F0T03_RS15210	COG0745	RESPONSE REGULATOR receiver
F0T03_RS15225	COG0033	Phosphoglucomutase
F0T03_RS15230	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
F0T03_RS15235	COG0596	Alpha beta hydrolase
F0T03_RS15245	COG0840	transmembrane signaling receptor activity
F0T03_RS15255	COG0735	belongs to the Fur family
F0T03_RS15275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F0T03_RS15280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS15280	COG2190	(PTS) system
F0T03_RS15280	COG1263	PTS System
F0T03_RS15285	COG0363	glucosamine-6-phosphate deaminase activity
F0T03_RS15290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F0T03_RS15295	COG1940	carbohydrate kinase activity
F0T03_RS15295	COG1846	Transcriptional regulator
F0T03_RS15300	COG0647	UMP catabolic process
F0T03_RS15305	COG0367	asparagine synthase
F0T03_RS15340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0T03_RS15345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F0T03_RS15350	COG1702	phosphate starvation-inducible protein PhoH
F0T03_RS15355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F0T03_RS15360	COG4535	Mg2 and Co2 transporter CorC
F0T03_RS15365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F0T03_RS15380	COG0765	amino acid transport
F0T03_RS15385	COG0765	amino acid transport
F0T03_RS15390	COG1126	abc transporter atp-binding protein
F0T03_RS15400	COG2888	peptidyl-tyrosine sulfation
F0T03_RS15405	COG0495	leucyl-tRNA aminoacylation
F0T03_RS15410	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
F0T03_RS15415	COG1466	dna polymerase III delta subunit
F0T03_RS15420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F0T03_RS15425	COG0799	negative regulation of ribosome biogenesis
F0T03_RS15435	COG0768	penicillin binding
F0T03_RS15440	COG0772	Belongs to the SEDS family
F0T03_RS15445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F0T03_RS15450	COG1686	Belongs to the peptidase S11 family
F0T03_RS15455	COG2921	Belongs to the UPF0250 family
F0T03_RS15460	COG0321	lipoyl(octanoyl) transferase activity
F0T03_RS15465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F0T03_RS15470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F0T03_RS15475	COG3706	GGDEF domain
F0T03_RS15480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F0T03_RS15485	COG1278	Cold shock
F0T03_RS15490	COG1278	Cold shock
F0T03_RS15495	COG2197	response regulator
F0T03_RS15505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F0T03_RS15520	COG5265	(ABC) transporter
F0T03_RS15525	COG2850	peptidyl-arginine hydroxylation
F0T03_RS15540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0T03_RS15565	COG1943	Transposase
F0T03_RS15585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F0T03_RS15590	COG2501	S4 domain
F0T03_RS15595	COG0215	cysteine-tRNA ligase activity
F0T03_RS15600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0T03_RS15605	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0T03_RS15610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F0T03_RS15615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F0T03_RS15620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
F0T03_RS15625	COG4181	ATPase activity
F0T03_RS15630	COG2755	lipolytic protein G-D-S-L family
F0T03_RS15635	COG0300	oxidoreductase activity
F0T03_RS15640	COG3118	belongs to the thioredoxin family
F0T03_RS15645	COG0330	HflC and HflK could
F0T03_RS15650	COG1585	Membrane protein implicated in regulation of membrane protease activity
F0T03_RS15655	COG0789	Transcriptional regulator
F0T03_RS15660	COG2217	Heavy metal translocating P-type atpase
F0T03_RS15665	COG3735	TraB family
F0T03_RS15670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F0T03_RS15710	COG0582	viral genome integration into host DNA
F0T03_RS15715	COG0737	Belongs to the 5'-nucleotidase family
F0T03_RS15720	COG2223	nitrite transmembrane transporter activity
F0T03_RS15725	COG4651	solute:proton antiporter activity
F0T03_RS15725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F0T03_RS15730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0T03_RS15760	COG0438	transferase activity, transferring glycosyl groups
F0T03_RS15765	COG1215	transferase activity, transferring glycosyl groups
F0T03_RS15770	COG1442	glycosyl transferase family 8
F0T03_RS15770	COG1216	Glycosyl transferase, family 2
F0T03_RS15775	COG2244	polysaccharide biosynthetic process
F0T03_RS15780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F0T03_RS15785	COG0563	adenylate kinase activity
F0T03_RS15790	COG0326	Molecular chaperone. Has ATPase activity
F0T03_RS15795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F0T03_RS15800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F0T03_RS15810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F0T03_RS15815	COG2832	Protein of unknown function (DUF454)
F0T03_RS15830	COG1196	nuclear chromosome segregation
F0T03_RS15830	COG3264	Mechanosensitive ion channel
F0T03_RS15835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0T03_RS15840	COG1309	transcriptional regulator
F0T03_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS15850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS15860	COG3457	Alanine racemase
F0T03_RS15865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F0T03_RS15870	COG0254	rRNA binding
F0T03_RS15875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0T03_RS15880	COG0803	Belongs to the bacterial solute-binding protein 9 family
F0T03_RS15885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F0T03_RS15890	COG1121	(ABC) transporter
F0T03_RS15915	COG3695	enzyme binding
F0T03_RS15920	COG3126	Type III secretion system lipoprotein chaperone (YscW)
F0T03_RS15925	COG1946	Acyl-CoA thioesterase
F0T03_RS15930	COG0004	ammonium transporteR
F0T03_RS15935	COG0347	Belongs to the P(II) protein family
F0T03_RS15940	COG1132	(ABC) transporter
F0T03_RS15945	COG1132	(ABC) transporter
F0T03_RS15950	COG1522	sequence-specific DNA binding
F0T03_RS15955	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F0T03_RS15960	COG0561	phosphatase activity
F0T03_RS15965	COG4533	DNA binding
F0T03_RS15970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F0T03_RS15975	COG0824	Thioesterase
F0T03_RS15980	COG1555	photosystem II stabilization
F0T03_RS15985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F0T03_RS15990	COG0776	regulation of translation
F0T03_RS15995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F0T03_RS16000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F0T03_RS16010	COG0544	peptidyl-prolyl cis-trans isomerase activity
F0T03_RS16020	COG0271	Belongs to the BolA IbaG family
F0T03_RS16025	COG3056	Lipoprotein
F0T03_RS16030	COG2223	nitrite transmembrane transporter activity
F0T03_RS16040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F0T03_RS16045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F0T03_RS16050	COG1845	cytochrome c oxidase, subunit III
F0T03_RS16055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F0T03_RS16060	COG0109	protoheme IX farnesyltransferase activity
F0T03_RS16065	COG2814	Major facilitator Superfamily
F0T03_RS16070	COG1666	GTP binding
F0T03_RS16075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F0T03_RS16080	COG0693	protein deglycase activity
F0T03_RS16085	COG0301	tRNA thio-modification
F0T03_RS16085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F0T03_RS16090	COG1722	exodeoxyribonuclease VII activity
F0T03_RS16095	COG0142	geranyltranstransferase activity
F0T03_RS16100	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F0T03_RS16105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F0T03_RS16110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F0T03_RS16115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0T03_RS16120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F0T03_RS16125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0T03_RS16125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F0T03_RS16130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F0T03_RS16140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0T03_RS16145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F0T03_RS16150	COG1862	Preprotein translocase
F0T03_RS16155	COG0343	queuine tRNA-ribosyltransferase activity
F0T03_RS16165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F0T03_RS16170	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
F0T03_RS16175	COG0450	alkyl hydroperoxide reductase
F0T03_RS16190	COG0366	Alpha amylase catalytic
F0T03_RS16200	COG1114	Component of the transport system for branched-chain amino acids
F0T03_RS16210	COG5002	protein histidine kinase activity
F0T03_RS16215	COG0745	RESPONSE REGULATOR receiver
F0T03_RS16220	COG0420	3'-5' exonuclease activity
F0T03_RS16225	COG0419	ATPase involved in DNA repair
F0T03_RS16230	COG1940	carbohydrate kinase activity
F0T03_RS16235	COG2974	May be involved in recombination
F0T03_RS16240	COG3123	guanosine phosphorylase activity
F0T03_RS16245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0T03_RS16255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F0T03_RS16270	COG2226	methyltransferase
F0T03_RS16285	COG3459	Glycosyltransferase 36 associated
F0T03_RS16305	COG2188	Transcriptional regulator
F0T03_RS16310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F0T03_RS16315	COG2313	pseudouridylate synthase activity
F0T03_RS16320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0T03_RS16325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F0T03_RS16330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F0T03_RS16345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F0T03_RS16350	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0T03_RS16355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F0T03_RS16370	COG2964	Protein conserved in bacteria
F0T03_RS16375	COG1181	Belongs to the D-alanine--D-alanine ligase family
F0T03_RS16380	COG0584	glycerophosphoryl diester phosphodiesterase
F0T03_RS16385	COG2991	Protein conserved in bacteria
F0T03_RS16390	COG1477	protein flavinylation
F0T03_RS16395	COG2871	sodium ion transport
F0T03_RS16400	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0T03_RS16405	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0T03_RS16410	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0T03_RS16415	COG1805	sodium ion transport
F0T03_RS16420	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
F0T03_RS16425	COG3034	peptidoglycan biosynthetic process
F0T03_RS16430	COG0121	glutamine amidotransferase
F0T03_RS16435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0T03_RS16440	COG1960	acyl-CoA dehydrogenase activity
F0T03_RS16445	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
F0T03_RS16460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
F0T03_RS16465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F0T03_RS16470	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F0T03_RS16475	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
F0T03_RS16480	COG0235	Class ii aldolase
F0T03_RS16485	COG0436	Aminotransferase
F0T03_RS16495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F0T03_RS16500	COG0583	DNA-binding transcription factor activity
F0T03_RS16505	COG2814	Major facilitator Superfamily
F0T03_RS16510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F0T03_RS16520	COG1846	Transcriptional regulator
F0T03_RS16525	COG1538	Outer membrane efflux protein
F0T03_RS16530	COG1566	PFAM secretion protein HlyD family protein
F0T03_RS16535	COG2814	Major facilitator Superfamily
F0T03_RS16540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F0T03_RS16545	COG3118	belongs to the thioredoxin family
F0T03_RS16555	COG0045	succinate-CoA ligase (ADP-forming) activity
F0T03_RS16555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F0T03_RS16555	COG1042	CoA-binding domain protein
F0T03_RS16560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F0T03_RS16565	COG5544	Lipoprotein
F0T03_RS16600	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F0T03_RS16610	COG2011	ABC-type metal ion transport system permease component
F0T03_RS16615	COG1464	Belongs to the NlpA lipoprotein family
F0T03_RS16625	COG1720	tRNA m6t6A37 methyltransferase activity
F0T03_RS16630	COG0442	prolyl-tRNA aminoacylation
F0T03_RS16635	COG3015	lipoprotein NlpE involved in copper resistance
F0T03_RS16645	COG4681	YaeQ
F0T03_RS16655	COG4568	rho-dependent transcription termination
F0T03_RS16665	COG0037	tRNA processing
F0T03_RS16670	COG0346	lactoylglutathione lyase activity
F0T03_RS16680	COG0825	malonyl-CoA metabolic process
F0T03_RS16685	COG0587	DNA-directed DNA polymerase activity
F0T03_RS16690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F0T03_RS16695	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0T03_RS16700	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0T03_RS16705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F0T03_RS16710	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F0T03_RS16715	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
F0T03_RS16725	COG0750	zinc metalloprotease
F0T03_RS16730	COG0575	Belongs to the CDS family
F0T03_RS16735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F0T03_RS16740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F0T03_RS16750	COG0528	UMP kinase activity
F0T03_RS16755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F0T03_RS16760	COG0052	Belongs to the universal ribosomal protein uS2 family
F0T03_RS16765	COG0024	Methionine aminopeptidase
F0T03_RS16770	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F0T03_RS16775	COG2171	N-acyltransferase activity
F0T03_RS16790	COG0564	pseudouridine synthase activity
F0T03_RS16795	COG3098	single-species biofilm formation
F0T03_RS16805	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0T03_RS16805	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F0T03_RS16810	COG1611	Belongs to the LOG family
F0T03_RS16815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F0T03_RS16820	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
F0T03_RS16825	COG2363	Small membrane protein
F0T03_RS16830	COG0583	DNA-binding transcription factor activity
F0T03_RS16840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F0T03_RS16845	COG2166	iron-sulfur cluster assembly
F0T03_RS16850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F0T03_RS16855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
F0T03_RS16875	COG0860	N-Acetylmuramoyl-L-alanine amidase
F0T03_RS16880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F0T03_RS16880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F0T03_RS16885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F0T03_RS16890	COG1074	ATP-dependent DNA helicase activity
F0T03_RS16895	COG1025	Belongs to the peptidase M16 family
F0T03_RS16900	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
F0T03_RS16925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F0T03_RS16930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F0T03_RS16940	COG1051	belongs to the nudix hydrolase family
F0T03_RS16945	COG3066	DNA modification
F0T03_RS16950	COG0861	Integral membrane protein TerC family
F0T03_RS16955	COG0667	Aldo Keto reductase
F0T03_RS16960	COG0477	Major facilitator Superfamily
F0T03_RS16965	COG0318	PFAM AMP-dependent synthetase and ligase
F0T03_RS16965	COG0204	Acyl-transferase
F0T03_RS16975	COG1609	Transcriptional regulator
F0T03_RS16980	COG0019	diaminopimelate decarboxylase activity
F0T03_RS16985	COG0583	DNA-binding transcription factor activity
F0T03_RS16990	COG2814	Major facilitator Superfamily
F0T03_RS16995	COG0583	DNA-binding transcription factor activity
F0T03_RS17055	COG2165	general secretion pathway protein
F0T03_RS17085	COG0288	reversible hydration of carbon dioxide
F0T03_RS17090	COG1733	regulation of RNA biosynthetic process
F0T03_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS17110	COG0484	heat shock protein binding
F0T03_RS17115	COG1609	Transcriptional regulator
F0T03_RS17120	COG2271	Major facilitator Superfamily
F0T03_RS17135	COG1522	sequence-specific DNA binding
F0T03_RS17140	COG3706	GGDEF domain
F0T03_RS17180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F0T03_RS17190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F0T03_RS17195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F0T03_RS17200	COG4974	Belongs to the 'phage' integrase family
F0T03_RS17205	COG0716	FMN binding
F0T03_RS17210	COG4452	Inner membrane protein CreD
F0T03_RS17215	COG2205	protein histidine kinase activity
F0T03_RS17220	COG0745	RESPONSE REGULATOR receiver
F0T03_RS17230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F0T03_RS17235	COG0354	folic acid binding
F0T03_RS17240	COG1272	protein, Hemolysin III
F0T03_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS17260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0T03_RS17260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F0T03_RS17265	COG0509	glycine decarboxylation via glycine cleavage system
F0T03_RS17270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F0T03_RS17275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0T03_RS17280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F0T03_RS17285	COG0006	proline dipeptidase activity
F0T03_RS17290	COG3079	Belongs to the UPF0149 family
F0T03_RS17295	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F0T03_RS17305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F0T03_RS17310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F0T03_RS17315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F0T03_RS17320	COG0583	DNA-binding transcription factor activity
F0T03_RS17330	COG1279	arginine transmembrane transporter activity
F0T03_RS17345	COG0191	fructose-bisphosphate aldolase activity
F0T03_RS17350	COG0126	phosphoglycerate kinase activity
F0T03_RS17355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0T03_RS17360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F0T03_RS17365	COG0501	Belongs to the peptidase M48B family
F0T03_RS17375	COG1166	arginine decarboxylase activity
F0T03_RS17395	COG0640	Transcriptional regulator
F0T03_RS17400	COG3091	SprT-like family
F0T03_RS17405	COG2356	endonuclease I
F0T03_RS17410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F0T03_RS17415	COG0189	ligase activity
F0T03_RS17420	COG1678	Uncharacterized ACR, COG1678
F0T03_RS17425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F0T03_RS17430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0T03_RS17440	COG2805	Type II/IV secretion system protein
F0T03_RS17445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F0T03_RS17450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F0T03_RS17455	COG0762	integral membrane protein
F0T03_RS17460	COG1872	DUF167
F0T03_RS17465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F0T03_RS17470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F0T03_RS17480	COG2066	Belongs to the glutaminase family
F0T03_RS17485	COG3171	Protein conserved in bacteria
F0T03_RS17490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F0T03_RS17495	COG1194	a g-specific adenine glycosylase
F0T03_RS17505	COG0741	lytic transglycosylase activity
F0T03_RS17515	COG1982	Orn Lys Arg decarboxylase major
F0T03_RS17665	COG2885	chlorophyll binding
F0T03_RS17690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F0T03_RS17755	COG1157	protein secretion by the type III secretion system
F0T03_RS17765	COG4789	Type iii secretion
F0T03_RS17840	COG5002	protein histidine kinase activity
F0T03_RS17855	COG1289	transmembrane transporter activity
F0T03_RS17880	COG0024	Methionine aminopeptidase
F0T03_RS17885	COG4604	ABC transporter, ATP-binding protein
F0T03_RS17890	COG4605	iron ion homeostasis
F0T03_RS17900	COG4607	ABC-type enterochelin transport system periplasmic component
F0T03_RS17905	COG1017	nitric oxide dioxygenase activity
F0T03_RS17905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F0T03_RS17910	COG0477	Major facilitator Superfamily
F0T03_RS17915	COG1609	Transcriptional regulator
F0T03_RS17925	COG1283	sodium-dependent phosphate transmembrane transporter activity
F0T03_RS17930	COG2195	Cleaves the N-terminal amino acid of tripeptides
F0T03_RS17935	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
F0T03_RS17950	COG0477	Major facilitator Superfamily
F0T03_RS17965	COG0583	DNA-binding transcription factor activity
F0T03_RS17980	COG0471	metal ion transport
F0T03_RS17985	COG5001	Diguanylate cyclase
F0T03_RS17995	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F0T03_RS18005	COG0477	Major facilitator Superfamily
F0T03_RS18010	COG1566	PFAM secretion protein HlyD family protein
F0T03_RS18015	COG2197	response regulator
F0T03_RS18020	COG0784	Response regulator, receiver
F0T03_RS18020	COG2205	protein histidine kinase activity
F0T03_RS18020	COG2198	Histidine kinase
F0T03_RS18020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS18025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F0T03_RS18030	COG0679	Auxin Efflux Carrier
F0T03_RS18035	COG0028	Belongs to the TPP enzyme family
F0T03_RS18055	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F0T03_RS18060	COG0309	Hydrogenase expression formation protein (HypE)
F0T03_RS18065	COG0409	Hydrogenase expression formation protein
F0T03_RS18070	COG0298	carbon dioxide binding
F0T03_RS18075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
F0T03_RS18080	COG0375	protein maturation
F0T03_RS18085	COG1773	rubredoxin
F0T03_RS18090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F0T03_RS18095	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F0T03_RS18100	COG5557	Pfam Polysulphide reductase, NrfD
F0T03_RS18105	COG0437	4 iron, 4 sulfur cluster binding
F0T03_RS18110	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
F0T03_RS18115	COG3133	Outer membrane lipoprotein
F0T03_RS18125	COG3710	Transcriptional regulator
F0T03_RS18125	COG0457	Tetratricopeptide repeat
F0T03_RS18130	COG3829	transcription factor binding
F0T03_RS18135	COG0840	transmembrane signaling receptor activity
F0T03_RS18140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F0T03_RS18145	COG2271	Major facilitator Superfamily
F0T03_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
F0T03_RS18155	COG1535	isochorismatase
F0T03_RS18155	COG3433	isochorismatase activity
F0T03_RS18160	COG1021	2,3-dihydroxybenzoate-AMP ligase
F0T03_RS18165	COG1169	isochorismate synthase
F0T03_RS18170	COG4592	Periplasmic binding protein
F0T03_RS18180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0T03_RS18185	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F0T03_RS18190	COG1120	ATPase activity
F0T03_RS18195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F0T03_RS18210	COG4774	siderophore transport
F0T03_RS18220	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS18230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F0T03_RS18235	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F0T03_RS18310	COG0848	biopolymer transport protein
F0T03_RS18315	COG0811	peptide transport
F0T03_RS18325	COG0586	Pfam SNARE associated Golgi protein
F0T03_RS18330	COG2207	Transcriptional regulator
F0T03_RS18340	COG1979	alcohol dehydrogenase
F0T03_RS18345	COG0656	L-ascorbic acid biosynthetic process
F0T03_RS18355	COG2132	Multicopper oxidase
F0T03_RS18360	COG0204	Acyl-transferase
F0T03_RS18365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F0T03_RS18370	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0T03_RS18385	COG0187	DNA topoisomerase II activity
F0T03_RS18390	COG3150	esterase
F0T03_RS18395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F0T03_RS18400	COG3151	Protein conserved in bacteria
F0T03_RS18405	COG0494	nUDIX hydrolase
F0T03_RS18410	COG1538	Outer membrane efflux protein
F0T03_RS18420	COG0754	glutathionylspermidine amidase activity
F0T03_RS18425	COG3384	dioxygenase
F0T03_RS18430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F0T03_RS18440	COG0531	amino acid
F0T03_RS18445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F0T03_RS18445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F0T03_RS18450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F0T03_RS18455	COG3025	triphosphatase activity
F0T03_RS18460	COG4991	sh3 domain protein
F0T03_RS18465	COG0617	tRNA 3'-terminal CCA addition
F0T03_RS18470	COG1968	undecaprenyl-diphosphatase activity
F0T03_RS18475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F0T03_RS18480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F0T03_RS18485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F0T03_RS18495	COG0358	DNA primase activity
F0T03_RS18500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F0T03_RS18525	COG2003	Belongs to the UPF0758 family
F0T03_RS18530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F0T03_RS18555	COG2378	regulation of single-species biofilm formation
F0T03_RS18565	COG3596	GTP binding
F0T03_RS18595	COG1479	Protein of unknown function DUF262
F0T03_RS18605	COG1204	response to ionizing radiation
F0T03_RS18650	COG0542	response to heat
F0T03_RS18665	COG4983	Phage plasmid primase, P4 family domain protein
F0T03_RS18705	COG2066	Belongs to the glutaminase family
F0T03_RS18710	COG0531	amino acid
F0T03_RS18715	COG0076	glutamate decarboxylase activity
F0T03_RS18725	COG2814	Major facilitator Superfamily
F0T03_RS18730	COG3247	response to pH
F0T03_RS18740	COG2378	regulation of single-species biofilm formation
F0T03_RS18750	COG0446	pyridine nucleotide-disulphide oxidoreductase
F0T03_RS18750	COG1902	pentaerythritol trinitrate reductase activity
F0T03_RS18755	COG2813	Specifically methylates the guanine in position
F0T03_RS18765	COG1451	nucleotide metabolic process
F0T03_RS18770	COG0673	inositol 2-dehydrogenase activity
F0T03_RS18775	COG0861	Integral membrane protein TerC family
F0T03_RS18780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
F0T03_RS18790	COG2721	sulfolactate sulfo-lyase activity
F0T03_RS18795	COG0246	Mannitol dehydrogenase
F0T03_RS18800	COG1904	glucuronate isomerase
F0T03_RS18805	COG2271	Major facilitator Superfamily
F0T03_RS18820	COG0586	Pfam SNARE associated Golgi protein
F0T03_RS18835	COG4575	ribosome binding
F0T03_RS18840	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
F0T03_RS18850	COG2259	Doxx family
F0T03_RS18855	COG0435	Glutathione S-transferase
F0T03_RS18860	COG0583	DNA-binding transcription factor activity
F0T03_RS18865	COG1741	Belongs to the pirin family
F0T03_RS18870	COG1064	alcohol dehydrogenase
F0T03_RS18875	COG0667	Aldo Keto reductase
F0T03_RS18895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F0T03_RS18905	COG0792	nuclease activity
F0T03_RS18910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F0T03_RS18915	COG2823	Periplasmic or secreted lipoprotein
F0T03_RS18920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F0T03_RS18925	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F0T03_RS18930	COG0784	Response regulator, receiver
F0T03_RS18930	COG5002	protein histidine kinase activity
F0T03_RS18930	COG2198	Histidine kinase
F0T03_RS18935	COG1242	4 iron, 4 sulfur cluster binding
F0T03_RS18940	COG0067	glutamate synthase
F0T03_RS18940	COG0069	glutamate synthase activity
F0T03_RS18940	COG0070	glutamate synthase
F0T03_RS18945	COG0493	'glutamate synthase
F0T03_RS18955	COG2969	positive regulation of protein catabolic process
F0T03_RS18960	COG0625	glutathione transferase activity
F0T03_RS18965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F0T03_RS18970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F0T03_RS18975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F0T03_RS18980	COG3105	Protein conserved in bacteria
F0T03_RS18985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0T03_RS18990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F0T03_RS18995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F0T03_RS19000	COG5007	Belongs to the BolA IbaG family
F0T03_RS19005	COG3113	response to antibiotic
F0T03_RS19010	COG2854	intermembrane phospholipid transfer
F0T03_RS19015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F0T03_RS19020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F0T03_RS19025	COG1127	ABC transporter
F0T03_RS19030	COG0530	calcium, potassium:sodium antiporter activity
F0T03_RS19035	COG0517	IMP dehydrogenase activity
F0T03_RS19035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F0T03_RS19040	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F0T03_RS19045	COG3117	lipopolysaccharide transmembrane transporter activity
F0T03_RS19050	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F0T03_RS19055	COG1137	ATPase activity
F0T03_RS19060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F0T03_RS19070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS19075	COG1660	Displays ATPase and GTPase activities
F0T03_RS19080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS19090	COG0540	Belongs to the ATCase OTCase family
F0T03_RS19095	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
F0T03_RS19105	COG2308	Evidence 4 Homologs of previously reported genes of
F0T03_RS19125	COG0366	Alpha amylase catalytic
F0T03_RS19130	COG1263	PTS System
F0T03_RS19130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F0T03_RS19135	COG1609	Transcriptional regulator
F0T03_RS19140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F0T03_RS19145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS19145	COG3711	transcriptional antiterminator
F0T03_RS19150	COG2706	6-phosphogluconolactonase activity
F0T03_RS19165	COG3964	amidohydrolase
F0T03_RS19195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0T03_RS19200	COG3783	Cytochrome b(562)
F0T03_RS19205	COG0312	modulator of DNA gyrase
F0T03_RS19210	COG3028	Belongs to the UPF0307 family
F0T03_RS19215	COG2732	(Barnase) inhibitor
F0T03_RS19230	COG1289	transmembrane transporter activity
F0T03_RS19235	COG1566	PFAM secretion protein HlyD family protein
F0T03_RS19245	COG0583	DNA-binding transcription factor activity
F0T03_RS19250	COG0312	modulator of DNA gyrase
F0T03_RS19255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F0T03_RS19260	COG3164	Protein of unknown function
F0T03_RS19265	COG1530	ribonuclease E activity
F0T03_RS19275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F0T03_RS19280	COG1792	Involved in formation and maintenance of cell shape
F0T03_RS19285	COG1077	Cell shape determining protein MreB Mrl
F0T03_RS19290	COG2199	diguanylate cyclase activity
F0T03_RS19290	COG2200	EAL domain
F0T03_RS19295	COG0604	alcohol dehydrogenase
F0T03_RS19305	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F0T03_RS19310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F0T03_RS19315	COG0511	ligase activity, forming carbon-carbon bonds
F0T03_RS19320	COG0439	Biotin carboxylase
F0T03_RS19325	COG3924	membrane
F0T03_RS19330	COG4145	pantothenate transmembrane transporter activity
F0T03_RS19335	COG2264	protein methyltransferase activity
F0T03_RS19340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0T03_RS19345	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
F0T03_RS19350	COG3706	GGDEF domain
F0T03_RS19350	COG0745	RESPONSE REGULATOR receiver
F0T03_RS19355	COG3133	Outer membrane lipoprotein
F0T03_RS19360	COG1278	Cold shock
F0T03_RS19365	COG1278	Cold shock
F0T03_RS19370	COG0471	metal ion transport
F0T03_RS19375	COG1560	Kdo2-lipid A biosynthetic process
F0T03_RS19385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS19390	COG4597	amino acid ABC transporter
F0T03_RS19395	COG0765	amino acid transport
F0T03_RS19400	COG1126	abc transporter atp-binding protein
F0T03_RS19410	COG1380	Effector of murein hydrolase LrgA
F0T03_RS19415	COG0583	DNA-binding transcription factor activity
F0T03_RS19420	COG0025	NhaP-type Na H and K H
F0T03_RS19425	COG2252	PERMEase
F0T03_RS19435	COG0629	single-stranded DNA binding
F0T03_RS19440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F0T03_RS19445	COG2315	Protein conserved in bacteria
F0T03_RS19450	COG1448	Aminotransferase
F0T03_RS19455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F0T03_RS19460	COG0305	Participates in initiation and elongation during chromosome replication
F0T03_RS19480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F0T03_RS19490	COG0735	belongs to the Fur family
F0T03_RS19495	COG3237	CsbD-like
F0T03_RS19500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F0T03_RS19505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F0T03_RS19510	COG2937	Belongs to the GPAT DAPAT family
F0T03_RS19515	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F0T03_RS19520	COG3161	chorismate lyase activity
F0T03_RS19535	COG4580	involved in the transport of maltose and maltodextrins
F0T03_RS19550	COG2182	Extracellular solute-binding protein
F0T03_RS19555	COG1175	transmembrane transport
F0T03_RS19560	COG3833	ABC-type maltose transport systems, permease component
F0T03_RS19565	COG3223	Belongs to the PsiE family
F0T03_RS19575	COG0527	aspartate kinase activity
F0T03_RS19595	COG3852	Histidine kinase
F0T03_RS19600	COG2204	response regulator
F0T03_RS19605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F0T03_RS19610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F0T03_RS19615	COG2031	fatty acid transporter
F0T03_RS19620	COG0183	Belongs to the thiolase family
F0T03_RS19625	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
F0T03_RS19630	COG2224	Isocitrate lyase
F0T03_RS19635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
F0T03_RS19640	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F0T03_RS19685	COG0138	bifunctional purine biosynthesis protein purh
F0T03_RS19690	COG0151	Belongs to the GarS family
F0T03_RS19705	COG3068	Protein conserved in bacteria
F0T03_RS19710	COG1515	deoxyribonuclease V activity
F0T03_RS19715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F0T03_RS19720	COG2816	NAD+ diphosphatase activity
F0T03_RS19725	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
F0T03_RS19730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F0T03_RS19740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F0T03_RS19745	COG2104	thiamine diphosphate biosynthetic process
F0T03_RS19750	COG2022	thiamine diphosphate biosynthetic process
F0T03_RS19755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F0T03_RS19760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F0T03_RS19765	COG0085	RNA polymerase activity
F0T03_RS19770	COG0222	ribosome binding
F0T03_RS19775	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F0T03_RS19780	COG0081	regulation of translation
F0T03_RS19785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F0T03_RS19790	COG0250	Participates in transcription elongation, termination and antitermination
F0T03_RS19795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F0T03_RS19800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0T03_RS19830	COG1072	(Pantothenic acid kinase))
F0T03_RS19835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F0T03_RS19835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F0T03_RS19870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F0T03_RS19875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F0T03_RS19880	COG0009	L-threonylcarbamoyladenylate synthase
F0T03_RS19885	COG0551	DNA topoisomerase type I activity
F0T03_RS19895	COG0758	DNA mediated transformation
F0T03_RS19900	COG0242	peptide deformylase activity
F0T03_RS19905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F0T03_RS19910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F0T03_RS19910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F0T03_RS19915	COG0569	domain protein
F0T03_RS19920	COG1970	mechanosensitive ion channel activity
F0T03_RS19925	COG3036	rescue of stalled ribosome
F0T03_RS19930	COG0789	Transcriptional regulator
F0T03_RS19940	COG0203	ribosomal protein L17
F0T03_RS19945	COG0202	RNA polymerase activity
F0T03_RS19950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F0T03_RS19955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F0T03_RS19960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F0T03_RS19965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F0T03_RS19970	COG0201	protein transport
F0T03_RS19975	COG0200	Binds to the 23S rRNA
F0T03_RS19980	COG1841	ribosomal large subunit assembly
F0T03_RS19985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F0T03_RS19990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F0T03_RS19995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F0T03_RS20005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F0T03_RS20015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F0T03_RS20020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F0T03_RS20025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F0T03_RS20030	COG0255	Belongs to the universal ribosomal protein uL29 family
F0T03_RS20035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F0T03_RS20040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F0T03_RS20050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F0T03_RS20060	COG0089	rRNA binding
F0T03_RS20070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F0T03_RS20075	COG0051	transcription antitermination factor activity, RNA binding
F0T03_RS20090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F0T03_RS20100	COG0049	tRNA binding
F0T03_RS20105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F0T03_RS20110	COG2168	tRNA wobble position uridine thiolation
F0T03_RS20115	COG2923	Belongs to the DsrF TusC family
F0T03_RS20120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
F0T03_RS20125	COG2964	Protein conserved in bacteria
F0T03_RS20130	COG0545	Peptidyl-prolyl cis-trans isomerase
F0T03_RS20140	COG1047	Peptidyl-prolyl cis-trans
F0T03_RS20145	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
F0T03_RS20155	COG2249	NAD(P)H dehydrogenase (quinone) activity
F0T03_RS20160	COG0488	(ABC) transporter
F0T03_RS20170	COG2175	clavaminate synthase activity
F0T03_RS20175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F0T03_RS20185	COG4521	taurine ABC transporter
F0T03_RS20200	COG0429	hydrolase of the alpha beta-hydrolase fold
F0T03_RS20205	COG3089	Belongs to the UPF0270 family
F0T03_RS20210	COG3954	Phosphoribulokinase
F0T03_RS20215	COG1765	OsmC-like protein
F0T03_RS20225	COG1289	transmembrane transporter activity
F0T03_RS20240	COG0433	COG0433 Predicted ATPase
F0T03_RS20245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F0T03_RS20250	COG1486	melibiose metabolic process
F0T03_RS20255	COG1609	Transcriptional regulator
F0T03_RS20270	COG0738	Major facilitator superfamily
F0T03_RS20275	COG0402	S-adenosylhomocysteine deaminase activity
F0T03_RS20280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F0T03_RS20285	COG2146	nitrite reductase [NAD(P)H] activity
F0T03_RS20295	COG1648	precorrin-2 dehydrogenase activity
F0T03_RS20295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0T03_RS20300	COG0180	Tryptophanyl-tRNA synthetase
F0T03_RS20310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F0T03_RS20330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F0T03_RS20335	COG4796	Type ii and iii secretion system protein
F0T03_RS20360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F0T03_RS20365	COG0494	nUDIX hydrolase
F0T03_RS20375	COG1011	Hydrolase
F0T03_RS20380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F0T03_RS20390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F0T03_RS20400	COG0745	RESPONSE REGULATOR receiver
F0T03_RS20405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F0T03_RS20410	COG2183	response to ionizing radiation
F0T03_RS20420	COG1918	ferrous iron import across plasma membrane
F0T03_RS20425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F0T03_RS20440	COG0596	Alpha beta hydrolase
F0T03_RS20445	COG1040	competence protein
F0T03_RS20450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F0T03_RS20450	COG0316	Belongs to the HesB IscA family
F0T03_RS20455	COG1640	4-alpha-glucanotransferase
F0T03_RS20460	COG0058	SHG alpha-glucan phosphorylase activity
F0T03_RS20465	COG2909	trisaccharide binding
F0T03_RS20475	COG0705	Rhomboid family
F0T03_RS20480	COG1349	DNA-binding transcription factor activity
F0T03_RS20485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F0T03_RS20490	COG0058	SHG alpha-glucan phosphorylase activity
F0T03_RS20495	COG0297	glycogen (starch) synthase activity
F0T03_RS20505	COG1523	belongs to the glycosyl hydrolase 13 family
F0T03_RS20510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F0T03_RS20515	COG3275	phosphorelay sensor kinase activity
F0T03_RS20535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F0T03_RS20540	COG2095	MarC family integral membrane protein
F0T03_RS20545	COG3265	gluconokinase activity
F0T03_RS20550	COG2610	gluconate transmembrane transporter activity
F0T03_RS20555	COG1609	Transcriptional regulator
F0T03_RS20560	COG1741	Belongs to the pirin family
F0T03_RS20565	COG1247	-acetyltransferase
F0T03_RS20570	COG1082	Xylose isomerase domain protein TIM barrel
F0T03_RS20580	COG0673	inositol 2-dehydrogenase activity
F0T03_RS20585	COG3962	Belongs to the TPP enzyme family
F0T03_RS20590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0T03_RS20600	COG3718	enzyme involved in inositol metabolism
F0T03_RS20610	COG0477	Major facilitator Superfamily
F0T03_RS20610	COG2814	Major facilitator Superfamily
F0T03_RS20620	COG2814	Major facilitator Superfamily
F0T03_RS20625	COG0583	DNA-binding transcription factor activity
F0T03_RS20630	COG0561	phosphatase activity
F0T03_RS20635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F0T03_RS20640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F0T03_RS20640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
F0T03_RS20645	COG0583	DNA-binding transcription factor activity
F0T03_RS20650	COG1648	precorrin-2 dehydrogenase activity
F0T03_RS20650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F0T03_RS20660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F0T03_RS20670	COG4865	methylaspartate mutase activity
F0T03_RS20675	COG3799	methylaspartate ammonia-lyase activity
F0T03_RS20690	COG1301	dicarboxylic acid transport
F0T03_RS20695	COG2081	HI0933 family
F0T03_RS20700	COG0306	phosphate transporter
F0T03_RS20710	COG0589	response to stress
F0T03_RS20725	COG0742	ribosomal rna small subunit methyltransferase
F0T03_RS20735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F0T03_RS20740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F0T03_RS20765	COG1295	ribonuclease BN
F0T03_RS20770	COG2134	cdp-diacylglycerol pyrophosphatase
F0T03_RS20775	COG2982	Protein involved in outer membrane biogenesis
F0T03_RS20780	COG2200	EAL domain
F0T03_RS20785	COG1942	4-Oxalocrotonate Tautomerase
F0T03_RS20790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F0T03_RS20795	COG0612	Peptidase, M16
F0T03_RS20800	COG1301	dicarboxylic acid transport
F0T03_RS20810	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F0T03_RS20815	COG2200	EAL domain
F0T03_RS20815	COG2199	diguanylate cyclase activity
F0T03_RS20820	COG3118	belongs to the thioredoxin family
F0T03_RS20820	COG0457	Tetratricopeptide repeat
F0T03_RS20825	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F0T03_RS20830	COG1215	transferase activity, transferring glycosyl groups
F0T03_RS20835	COG1215	transferase activity, transferring glycosyl groups
F0T03_RS20860	COG2194	sulfuric ester hydrolase activity
F0T03_RS20865	COG4608	Belongs to the ABC transporter superfamily
F0T03_RS20870	COG0444	Belongs to the ABC transporter superfamily
F0T03_RS20875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F0T03_RS20880	COG0601	transmembrane transport
F0T03_RS20885	COG0747	negative chemotaxis
F0T03_RS20890	COG3210	domain, Protein
F0T03_RS20895	COG2831	hemolysin activation secretion protein
F0T03_RS20915	COG3851	Histidine kinase
F0T03_RS20920	COG2197	response regulator
F0T03_RS20925	COG2194	sulfuric ester hydrolase activity
F0T03_RS20930	COG1764	response to oxidative stress
F0T03_RS20950	COG0463	Glycosyl transferase, family 2
F0T03_RS20955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F0T03_RS20965	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
F0T03_RS20980	COG2986	histidine ammonia-lyase
F0T03_RS20985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F0T03_RS21010	COG0288	reversible hydration of carbon dioxide
F0T03_RS21015	COG0786	glutamate:sodium symporter activity
F0T03_RS21025	COG1609	Transcriptional regulator
F0T03_RS21025	COG2207	Transcriptional regulator
F0T03_RS21030	COG4214	carbohydrate transport
F0T03_RS21040	COG4213	ABC transporter substrate-binding protein
F0T03_RS21045	COG2115	Belongs to the xylose isomerase family
F0T03_RS21050	COG1070	Carbohydrate kinase
F0T03_RS21055	COG3121	Chaperone
F0T03_RS21060	COG1335	isochorismatase
F0T03_RS21070	COG3274	enterobacterial common antigen metabolic process
F0T03_RS21080	COG3276	selenocysteine insertion sequence binding
F0T03_RS21085	COG1921	L-seryl-tRNASec selenium transferase activity
F0T03_RS21090	COG3058	Necessary for formate dehydrogenase activity
F0T03_RS21095	COG2864	formate dehydrogenase
F0T03_RS21100	COG0437	4 iron, 4 sulfur cluster binding
F0T03_RS21110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F0T03_RS21115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F0T03_RS21120	COG0840	transmembrane signaling receptor activity
F0T03_RS21125	COG2258	MOSC domain
F0T03_RS21135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F0T03_RS21145	COG3722	fumarate hydratase activity
F0T03_RS21150	COG0246	Mannitol dehydrogenase
F0T03_RS21155	COG2213	PTS system mannitol-specific
F0T03_RS21155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F0T03_RS21165	COG0751	glycine-tRNA ligase activity
F0T03_RS21170	COG0752	glycyl-tRNA synthetase alpha subunit
F0T03_RS21175	COG2818	Glycosylase
F0T03_RS21180	COG0456	acetyltransferase
F0T03_RS21205	COG0366	Alpha amylase catalytic
F0T03_RS21210	COG3977	Valine--pyruvate aminotransferase
F0T03_RS21215	COG0569	domain protein
F0T03_RS21215	COG2985	domain, Protein
F0T03_RS21230	COG5645	(Lipo)protein
F0T03_RS21235	COG0823	Involved in the tonB-independent uptake of proteins
F0T03_RS21245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F0T03_RS21250	COG2423	ornithine cyclodeaminase activity
F0T03_RS21255	COG0561	phosphatase activity
F0T03_RS21260	COG0187	DNA topoisomerase II activity
F0T03_RS21265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F0T03_RS21275	COG0592	DNA-directed DNA polymerase activity
F0T03_RS21280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F0T03_RS21295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F0T03_RS21300	COG0594	ribonuclease P activity
F0T03_RS21310	COG0706	membrane insertase activity
F0T03_RS21315	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F0T03_RS21320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F0T03_RS21330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F0T03_RS21335	COG2011	ABC-type metal ion transport system permease component
F0T03_RS21340	COG0840	transmembrane signaling receptor activity
F0T03_RS21345	COG0431	NADPH-dependent FMN reductase
F0T03_RS21365	COG2252	PERMEase
F0T03_RS21370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F0T03_RS21375	COG0765	amino acid transport
F0T03_RS21380	COG0765	amino acid transport
F0T03_RS21385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F0T03_RS21395	COG0704	Plays a role in the regulation of phosphate uptake
F0T03_RS21405	COG0581	inorganic phosphate transmembrane transporter activity
F0T03_RS21410	COG0573	inorganic phosphate transmembrane transporter activity
F0T03_RS21415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F0T03_RS21420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F0T03_RS21425	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F0T03_RS21430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F0T03_RS21435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F0T03_RS21445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F0T03_RS21450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F0T03_RS21455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F0T03_RS21465	COG0356	it plays a direct role in the translocation of protons across the membrane
F0T03_RS21470	COG3312	ion transport
F0T03_RS21475	COG0357	Ribosomal RNA small subunit methyltransferase G
F0T03_RS21480	COG0445	tRNA wobble uridine modification