locus-tag	class	description
LOKVESSMR4R_RS00020	COG3451	type IV secretory pathway VirB4
LOKVESSMR4R_RS00025	COG3846	protein secretion by the type IV secretion system
LOKVESSMR4R_RS00040	COG2948	multi-organism process
LOKVESSMR4R_RS00215	COG0776	regulation of translation
LOKVESSMR4R_RS00260	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS00265	COG0517	IMP dehydrogenase activity
LOKVESSMR4R_RS00270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LOKVESSMR4R_RS00280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LOKVESSMR4R_RS00285	COG1268	BioY protein
LOKVESSMR4R_RS00295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LOKVESSMR4R_RS00300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LOKVESSMR4R_RS00310	COG1136	(ABC) transporter
LOKVESSMR4R_RS00315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LOKVESSMR4R_RS00330	COG2022	thiamine diphosphate biosynthetic process
LOKVESSMR4R_RS00345	COG0351	phosphomethylpyrimidine kinase
LOKVESSMR4R_RS00350	COG0778	Nitroreductase
LOKVESSMR4R_RS00355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LOKVESSMR4R_RS00360	COG0602	queuosine metabolic process
LOKVESSMR4R_RS00365	COG0720	synthase
LOKVESSMR4R_RS00370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LOKVESSMR4R_RS00375	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS00395	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LOKVESSMR4R_RS00400	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LOKVESSMR4R_RS00410	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS00425	COG2132	Multicopper oxidase
LOKVESSMR4R_RS00445	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKVESSMR4R_RS00495	COG1937	Protein conserved in bacteria
LOKVESSMR4R_RS00515	COG3547	Transposase (IS116 IS110 IS902 family)
LOKVESSMR4R_RS00535	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS00540	COG0582	viral genome integration into host DNA
LOKVESSMR4R_RS00545	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS00580	COG0789	Transcriptional regulator
LOKVESSMR4R_RS00595	COG1162	GTPase activity
LOKVESSMR4R_RS00675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOKVESSMR4R_RS00680	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LOKVESSMR4R_RS00685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LOKVESSMR4R_RS00690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LOKVESSMR4R_RS00695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LOKVESSMR4R_RS00710	COG0596	Alpha beta hydrolase
LOKVESSMR4R_RS00720	COG2983	Belongs to the UPF0260 family
LOKVESSMR4R_RS00725	COG0196	riboflavin kinase activity
LOKVESSMR4R_RS00730	COG2030	dehydratase
LOKVESSMR4R_RS00740	COG1227	inorganic diphosphatase activity
LOKVESSMR4R_RS00780	COG3768	UPF0283 membrane protein
LOKVESSMR4R_RS00785	COG3106	COG3106 Predicted ATPase
LOKVESSMR4R_RS00790	COG0101	tRNA pseudouridine synthase activity
LOKVESSMR4R_RS00795	COG0729	surface antigen
LOKVESSMR4R_RS00815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LOKVESSMR4R_RS00820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LOKVESSMR4R_RS00825	COG3698	Phosphodiester glycosidase
LOKVESSMR4R_RS00840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKVESSMR4R_RS00845	COG2835	tetraacyldisaccharide 4'-kinase activity
LOKVESSMR4R_RS00855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LOKVESSMR4R_RS00860	COG0154	amidase activity
LOKVESSMR4R_RS00870	COG1674	ftsk spoiiie
LOKVESSMR4R_RS00880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LOKVESSMR4R_RS00895	COG0328	RNA-DNA hybrid ribonuclease activity
LOKVESSMR4R_RS00905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LOKVESSMR4R_RS00910	COG0534	Mate efflux family protein
LOKVESSMR4R_RS00920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LOKVESSMR4R_RS00925	COG1758	RNA polymerase activity
LOKVESSMR4R_RS00930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LOKVESSMR4R_RS00940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LOKVESSMR4R_RS00945	COG0736	holo-[acyl-carrier-protein] synthase activity
LOKVESSMR4R_RS00950	COG0681	Belongs to the peptidase S26 family
LOKVESSMR4R_RS00955	COG0571	ribonuclease III activity
LOKVESSMR4R_RS00960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LOKVESSMR4R_RS00970	COG1381	Involved in DNA repair and RecF pathway recombination
LOKVESSMR4R_RS00990	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LOKVESSMR4R_RS00995	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS01000	COG2205	protein histidine kinase activity
LOKVESSMR4R_RS01010	COG1660	Displays ATPase and GTPase activities
LOKVESSMR4R_RS01020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LOKVESSMR4R_RS01025	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_RS01045	COG2096	Adenosyltransferase
LOKVESSMR4R_RS01055	COG0300	oxidoreductase activity
LOKVESSMR4R_RS01060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LOKVESSMR4R_RS01065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LOKVESSMR4R_RS01085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LOKVESSMR4R_RS01090	COG0250	Participates in transcription elongation, termination and antitermination
LOKVESSMR4R_RS01095	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LOKVESSMR4R_RS01100	COG0081	regulation of translation
LOKVESSMR4R_RS01110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LOKVESSMR4R_RS01115	COG0222	ribosome binding
LOKVESSMR4R_RS01120	COG0085	RNA polymerase activity
LOKVESSMR4R_RS01125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LOKVESSMR4R_RS01140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LOKVESSMR4R_RS01145	COG0049	tRNA binding
LOKVESSMR4R_RS01150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LOKVESSMR4R_RS01155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LOKVESSMR4R_RS01165	COG0051	transcription antitermination factor activity, RNA binding
LOKVESSMR4R_RS01170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LOKVESSMR4R_RS01175	COG0088	Forms part of the polypeptide exit tunnel
LOKVESSMR4R_RS01180	COG0089	rRNA binding
LOKVESSMR4R_RS01185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LOKVESSMR4R_RS01190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LOKVESSMR4R_RS01195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LOKVESSMR4R_RS01200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LOKVESSMR4R_RS01205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LOKVESSMR4R_RS01220	COG0255	Belongs to the universal ribosomal protein uL29 family
LOKVESSMR4R_RS01225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LOKVESSMR4R_RS01230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LOKVESSMR4R_RS01235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LOKVESSMR4R_RS01240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LOKVESSMR4R_RS01245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LOKVESSMR4R_RS01250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LOKVESSMR4R_RS01255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LOKVESSMR4R_RS01260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LOKVESSMR4R_RS01265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LOKVESSMR4R_RS01270	COG1841	ribosomal large subunit assembly
LOKVESSMR4R_RS01275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKVESSMR4R_RS01280	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LOKVESSMR4R_RS01285	COG3830	Belongs to the UPF0237 family
LOKVESSMR4R_RS01285	COG0560	Phosphoserine phosphatase
LOKVESSMR4R_RS01300	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS01315	COG1120	ATPase activity
LOKVESSMR4R_RS01325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOKVESSMR4R_RS01330	COG3604	Transcriptional regulator
LOKVESSMR4R_RS01335	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_RS01335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKVESSMR4R_RS01340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_RS01345	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_RS01350	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LOKVESSMR4R_RS01355	COG2358	TRAP transporter, solute receptor (TAXI family
LOKVESSMR4R_RS01375	COG0765	amino acid transport
LOKVESSMR4R_RS01380	COG0765	amino acid transport
LOKVESSMR4R_RS01400	COG1051	belongs to the nudix hydrolase family
LOKVESSMR4R_RS01405	COG0557	exoribonuclease II activity
LOKVESSMR4R_RS01415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOKVESSMR4R_RS01430	COG0469	pyruvate kinase activity
LOKVESSMR4R_RS01435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LOKVESSMR4R_RS01440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LOKVESSMR4R_RS01445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LOKVESSMR4R_RS01455	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_RS01460	COG0431	NADPH-dependent FMN reductase
LOKVESSMR4R_RS01470	COG0405	Gamma-glutamyltransferase
LOKVESSMR4R_RS01485	COG1396	sequence-specific DNA binding
LOKVESSMR4R_RS01515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LOKVESSMR4R_RS01520	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
LOKVESSMR4R_RS01525	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS01530	COG0686	Belongs to the AlaDH PNT family
LOKVESSMR4R_RS01535	COG1970	mechanosensitive ion channel activity
LOKVESSMR4R_RS01550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKVESSMR4R_RS01550	COG0072	phenylalanine-tRNA ligase activity
LOKVESSMR4R_RS01610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
LOKVESSMR4R_RS01630	COG0435	Glutathione S-transferase
LOKVESSMR4R_RS01670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LOKVESSMR4R_RS01675	COG0242	peptide deformylase activity
LOKVESSMR4R_RS01680	COG0242	peptide deformylase activity
LOKVESSMR4R_RS01685	COG0242	peptide deformylase activity
LOKVESSMR4R_RS01690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LOKVESSMR4R_RS01700	COG1376	ErfK ybiS ycfS ynhG family protein
LOKVESSMR4R_RS01725	COG1012	belongs to the aldehyde dehydrogenase family
LOKVESSMR4R_RS01750	COG3195	allantoin biosynthetic process
LOKVESSMR4R_RS01750	COG3648	Uricase
LOKVESSMR4R_RS01755	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LOKVESSMR4R_RS01760	COG2423	ornithine cyclodeaminase activity
LOKVESSMR4R_RS01765	COG3616	Alanine racemase, N-terminal domain
LOKVESSMR4R_RS01770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_RS01775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LOKVESSMR4R_RS01780	COG1414	Transcriptional regulator
LOKVESSMR4R_RS01785	COG0798	PFAM Bile acid sodium symporter
LOKVESSMR4R_RS01800	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS01825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS01830	COG0601	transmembrane transport
LOKVESSMR4R_RS01835	COG4166	transmembrane transport
LOKVESSMR4R_RS01840	COG2197	response regulator
LOKVESSMR4R_RS01885	COG0006	proline dipeptidase activity
LOKVESSMR4R_RS01895	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS01900	COG1802	Transcriptional regulator
LOKVESSMR4R_RS01910	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS01920	COG0747	negative chemotaxis
LOKVESSMR4R_RS01940	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS01950	COG2226	methyltransferase
LOKVESSMR4R_RS01955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LOKVESSMR4R_RS02000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS02010	COG4778	phosphonate C-P lyase system protein PhnL
LOKVESSMR4R_RS02015	COG4107	phosphonate C-P lyase system protein PhnK
LOKVESSMR4R_RS02020	COG3627	carbon phosphorus lyase activity
LOKVESSMR4R_RS02040	COG2186	Transcriptional regulator
LOKVESSMR4R_RS02050	COG0519	Catalyzes the synthesis of GMP from XMP
LOKVESSMR4R_RS02050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LOKVESSMR4R_RS02060	COG0174	glutamine synthetase
LOKVESSMR4R_RS02075	COG1234	tRNA 3'-trailer cleavage
LOKVESSMR4R_RS02080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKVESSMR4R_RS02105	COG1012	belongs to the aldehyde dehydrogenase family
LOKVESSMR4R_RS02110	COG5441	Belongs to the UPF0261 family
LOKVESSMR4R_RS02120	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LOKVESSMR4R_RS02130	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKVESSMR4R_RS02140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LOKVESSMR4R_RS02200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOKVESSMR4R_RS02215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LOKVESSMR4R_RS02220	COG5310	Homospermidine synthase
LOKVESSMR4R_RS02230	COG0287	Prephenate dehydrogenase
LOKVESSMR4R_RS02235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LOKVESSMR4R_RS02240	COG1183	phosphatidylcholine synthase activity
LOKVESSMR4R_RS02255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LOKVESSMR4R_RS02265	COG1435	thymidine kinase activity
LOKVESSMR4R_RS02270	COG0431	NADPH-dependent FMN reductase
LOKVESSMR4R_RS02280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LOKVESSMR4R_RS02285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LOKVESSMR4R_RS02290	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS02295	COG0346	lactoylglutathione lyase activity
LOKVESSMR4R_RS02335	COG1272	protein, Hemolysin III
LOKVESSMR4R_RS02350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKVESSMR4R_RS02360	COG0842	Transport permease protein
LOKVESSMR4R_RS02370	COG0697	spore germination
LOKVESSMR4R_RS02375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LOKVESSMR4R_RS02380	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LOKVESSMR4R_RS02385	COG1643	Atp-dependent helicase
LOKVESSMR4R_RS02390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LOKVESSMR4R_RS02395	COG1703	isobutyryl-CoA mutase activity
LOKVESSMR4R_RS02405	COG0481	GTPase activity
LOKVESSMR4R_RS02430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOKVESSMR4R_RS02440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_RS02455	COG0281	malic enzyme
LOKVESSMR4R_RS02455	COG0280	phosphate acetyltransferase
LOKVESSMR4R_RS02475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LOKVESSMR4R_RS02480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LOKVESSMR4R_RS02485	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LOKVESSMR4R_RS02495	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_RS02505	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_RS02505	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_RS02510	COG0183	Belongs to the thiolase family
LOKVESSMR4R_RS02515	COG0625	glutathione transferase activity
LOKVESSMR4R_RS02520	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS02525	COG0789	Transcriptional regulator
LOKVESSMR4R_RS02545	COG0534	Mate efflux family protein
LOKVESSMR4R_RS02560	COG0737	Belongs to the 5'-nucleotidase family
LOKVESSMR4R_RS02570	COG1132	(ABC) transporter
LOKVESSMR4R_RS02575	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_RS02585	COG2201	protein-glutamate methylesterase activity
LOKVESSMR4R_RS02595	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS02600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LOKVESSMR4R_RS02615	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS02630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LOKVESSMR4R_RS02630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LOKVESSMR4R_RS02650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKVESSMR4R_RS02655	COG0006	proline dipeptidase activity
LOKVESSMR4R_RS02660	COG3608	succinylglutamate desuccinylase aspartoacylase
LOKVESSMR4R_RS02675	COG2358	TRAP transporter, solute receptor (TAXI family
LOKVESSMR4R_RS02680	COG2094	Belongs to the DNA glycosylase MPG family
LOKVESSMR4R_RS02690	COG4681	YaeQ
LOKVESSMR4R_RS02700	COG1136	(ABC) transporter
LOKVESSMR4R_RS02745	COG0243	molybdopterin cofactor binding
LOKVESSMR4R_RS02745	COG3383	formate dehydrogenase (NAD+) activity
LOKVESSMR4R_RS02750	COG0437	4 iron, 4 sulfur cluster binding
LOKVESSMR4R_RS02755	COG2864	formate dehydrogenase
LOKVESSMR4R_RS02760	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_RS02780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LOKVESSMR4R_RS02795	COG2084	Dehydrogenase
LOKVESSMR4R_RS02805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LOKVESSMR4R_RS02810	COG0772	Belongs to the SEDS family
LOKVESSMR4R_RS02815	COG0768	penicillin binding
LOKVESSMR4R_RS02840	COG4221	oxidoreductase activity
LOKVESSMR4R_RS02845	COG3046	protein related to deoxyribodipyrimidine photolyase
LOKVESSMR4R_RS02860	COG1234	tRNA 3'-trailer cleavage
LOKVESSMR4R_RS02865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKVESSMR4R_RS02875	COG4181	ATPase activity
LOKVESSMR4R_RS02885	COG1278	Cold shock
LOKVESSMR4R_RS02890	COG1278	Cold shock
LOKVESSMR4R_RS02895	COG0488	(ABC) transporter
LOKVESSMR4R_RS02905	COG1115	amino acid carrier protein
LOKVESSMR4R_RS02915	COG1079	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS02920	COG4603	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS02925	COG3845	ABC transporter
LOKVESSMR4R_RS02935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LOKVESSMR4R_RS02945	COG0640	Transcriptional regulator
LOKVESSMR4R_RS02955	COG2900	Belongs to the SlyX family
LOKVESSMR4R_RS02965	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LOKVESSMR4R_RS02970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LOKVESSMR4R_RS02980	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_RS02990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOKVESSMR4R_RS02995	COG3718	enzyme involved in inositol metabolism
LOKVESSMR4R_RS03005	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS03015	COG1609	Transcriptional regulator
LOKVESSMR4R_RS03020	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS03030	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS03035	COG3962	Belongs to the TPP enzyme family
LOKVESSMR4R_RS03040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_RS03055	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS03080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKVESSMR4R_RS03105	COG2010	Cytochrome c
LOKVESSMR4R_RS03110	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS03115	COG0492	ferredoxin-NADP+ reductase activity
LOKVESSMR4R_RS03120	COG2046	Belongs to the sulfate adenylyltransferase family
LOKVESSMR4R_RS03120	COG0529	Catalyzes the synthesis of activated sulfate
LOKVESSMR4R_RS03140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LOKVESSMR4R_RS03145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LOKVESSMR4R_RS03165	COG0459	protein refolding
LOKVESSMR4R_RS03190	COG0348	domain, Protein
LOKVESSMR4R_RS03200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKVESSMR4R_RS03225	COG0632	four-way junction helicase activity
LOKVESSMR4R_RS03230	COG2255	four-way junction helicase activity
LOKVESSMR4R_RS03245	COG0824	Thioesterase
LOKVESSMR4R_RS03255	COG0848	biopolymer transport protein
LOKVESSMR4R_RS03265	COG0823	Involved in the tonB-independent uptake of proteins
LOKVESSMR4R_RS03270	COG2885	chlorophyll binding
LOKVESSMR4R_RS03280	COG0037	tRNA processing
LOKVESSMR4R_RS03285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKVESSMR4R_RS03295	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LOKVESSMR4R_RS03305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LOKVESSMR4R_RS03315	COG1201	RNA secondary structure unwinding
LOKVESSMR4R_RS03365	COG4964	Belongs to the GSP D family
LOKVESSMR4R_RS03375	COG0741	lytic transglycosylase activity
LOKVESSMR4R_RS03380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LOKVESSMR4R_RS03390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LOKVESSMR4R_RS03390	COG1754	DNA topoisomerase type I activity
LOKVESSMR4R_RS03395	COG0758	DNA mediated transformation
LOKVESSMR4R_RS03400	COG0312	modulator of DNA gyrase
LOKVESSMR4R_RS03420	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LOKVESSMR4R_RS03440	COG0612	Peptidase, M16
LOKVESSMR4R_RS03445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LOKVESSMR4R_RS03450	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_RS03455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LOKVESSMR4R_RS03460	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LOKVESSMR4R_RS03465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LOKVESSMR4R_RS03490	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS03505	COG0123	including yeast histone deacetylase and acetoin utilization protein
LOKVESSMR4R_RS03515	COG1519	Transferase
LOKVESSMR4R_RS03535	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS03550	COG0678	peroxiredoxin activity
LOKVESSMR4R_RS03630	COG0737	Belongs to the 5'-nucleotidase family
LOKVESSMR4R_RS03640	COG0077	Prephenate dehydratase
LOKVESSMR4R_RS03640	COG1605	Chorismate mutase
LOKVESSMR4R_RS03655	COG4174	ABC transporter (Permease)
LOKVESSMR4R_RS03660	COG4239	(ABC) transporter, permease
LOKVESSMR4R_RS03665	COG4172	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS03670	COG1686	Belongs to the peptidase S11 family
LOKVESSMR4R_RS03675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LOKVESSMR4R_RS03680	COG2813	Specifically methylates the guanine in position
LOKVESSMR4R_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS03695	COG0408	coproporphyrinogen oxidase activity
LOKVESSMR4R_RS03700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LOKVESSMR4R_RS03705	COG0181	hydroxymethylbilane synthase activity
LOKVESSMR4R_RS03720	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_RS03730	COG1294	oxidase, subunit
LOKVESSMR4R_RS03735	COG1271	oxidase subunit
LOKVESSMR4R_RS03740	COG2351	hydroxyisourate hydrolase activity
LOKVESSMR4R_RS03745	COG1454	alcohol dehydrogenase
LOKVESSMR4R_RS03750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LOKVESSMR4R_RS03765	COG0395	ABC-type sugar transport system, permease component
LOKVESSMR4R_RS03780	COG3842	ATPase activity
LOKVESSMR4R_RS03790	COG1349	DNA-binding transcription factor activity
LOKVESSMR4R_RS03795	COG0501	Belongs to the peptidase M48B family
LOKVESSMR4R_RS03815	COG0179	Fumarylacetoacetate (FAA) hydrolase
LOKVESSMR4R_RS03820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKVESSMR4R_RS03825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKVESSMR4R_RS03825	COG1321	iron dependent repressor
LOKVESSMR4R_RS03830	COG1121	(ABC) transporter
LOKVESSMR4R_RS03835	COG0803	Belongs to the bacterial solute-binding protein 9 family
LOKVESSMR4R_RS03845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LOKVESSMR4R_RS03860	COG2197	response regulator
LOKVESSMR4R_RS03890	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_RS03910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS03945	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS03955	COG1609	Transcriptional regulator
LOKVESSMR4R_RS03965	COG1175	transmembrane transport
LOKVESSMR4R_RS03990	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS03995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_RS04010	COG0318	PFAM AMP-dependent synthetase and ligase
LOKVESSMR4R_RS04070	COG2205	protein histidine kinase activity
LOKVESSMR4R_RS04110	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS04115	COG2963	transposase activity
LOKVESSMR4R_RS04135	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS04205	COG0678	peroxiredoxin activity
LOKVESSMR4R_RS04225	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS04230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LOKVESSMR4R_RS04260	COG0559	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS04270	COG1129	ABC transporter
LOKVESSMR4R_RS04285	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS04295	COG4372	Transposase
LOKVESSMR4R_RS04300	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS04305	COG2963	transposase activity
LOKVESSMR4R_RS04330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LOKVESSMR4R_RS04345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LOKVESSMR4R_RS04355	COG5328	Belongs to the UPF0262 family
LOKVESSMR4R_RS04360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LOKVESSMR4R_RS04370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LOKVESSMR4R_RS04385	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
LOKVESSMR4R_RS04390	COG1943	Transposase
LOKVESSMR4R_RS04400	COG1278	Cold shock
LOKVESSMR4R_RS04405	COG1393	Belongs to the ArsC family
LOKVESSMR4R_RS04410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LOKVESSMR4R_RS04435	COG3243	poly(R)-hydroxyalkanoic acid synthase
LOKVESSMR4R_RS04450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_RS04455	COG0174	glutamine synthetase
LOKVESSMR4R_RS04460	COG0519	Catalyzes the synthesis of GMP from XMP
LOKVESSMR4R_RS04465	COG0174	glutamine synthetase
LOKVESSMR4R_RS04470	COG4160	amino acid transport
LOKVESSMR4R_RS04475	COG4215	(ABC) transporter
LOKVESSMR4R_RS04500	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LOKVESSMR4R_RS04510	COG0504	CTP synthase activity
LOKVESSMR4R_RS04520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LOKVESSMR4R_RS04545	COG1760	l-serine dehydratase
LOKVESSMR4R_RS04550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LOKVESSMR4R_RS04565	COG0330	HflC and HflK could
LOKVESSMR4R_RS04580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
LOKVESSMR4R_RS04585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LOKVESSMR4R_RS04595	COG2873	o-acetylhomoserine
LOKVESSMR4R_RS04605	COG1285	pathogenesis
LOKVESSMR4R_RS04625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LOKVESSMR4R_RS04630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LOKVESSMR4R_RS04665	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS04690	COG3685	Protein conserved in bacteria
LOKVESSMR4R_RS04740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LOKVESSMR4R_RS04740	COG1017	nitric oxide dioxygenase activity
LOKVESSMR4R_RS04770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LOKVESSMR4R_RS04780	COG1832	CoA-binding protein
LOKVESSMR4R_RS04785	COG0140	phosphoribosyl-ATP diphosphatase activity
LOKVESSMR4R_RS04790	COG0107	imidazoleglycerol-phosphate synthase activity
LOKVESSMR4R_RS04795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LOKVESSMR4R_RS04810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LOKVESSMR4R_RS04815	COG0131	Imidazoleglycerol-phosphate dehydratase
LOKVESSMR4R_RS04835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
LOKVESSMR4R_RS04840	COG1304	FMN binding
LOKVESSMR4R_RS04845	COG0210	DNA helicase
LOKVESSMR4R_RS04855	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS04865	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_RS04875	COG2001	Belongs to the MraZ family
LOKVESSMR4R_RS04880	COG0275	rRNA processing
LOKVESSMR4R_RS04895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LOKVESSMR4R_RS04905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LOKVESSMR4R_RS04910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LOKVESSMR4R_RS04915	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_RS04920	COG2081	HI0933 family
LOKVESSMR4R_RS04935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LOKVESSMR4R_RS04945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LOKVESSMR4R_RS04950	COG1181	Belongs to the D-alanine--D-alanine ligase family
LOKVESSMR4R_RS04955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LOKVESSMR4R_RS04960	COG0849	cell division
LOKVESSMR4R_RS04965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LOKVESSMR4R_RS04975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOKVESSMR4R_RS04985	COG0038	chloride channel
LOKVESSMR4R_RS05030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOKVESSMR4R_RS05045	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LOKVESSMR4R_RS05055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LOKVESSMR4R_RS05060	COG2010	Cytochrome c
LOKVESSMR4R_RS05060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LOKVESSMR4R_RS05075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LOKVESSMR4R_RS05080	COG0752	glycyl-tRNA synthetase alpha subunit
LOKVESSMR4R_RS05095	COG0574	Belongs to the PEP-utilizing enzyme family
LOKVESSMR4R_RS05095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LOKVESSMR4R_RS05105	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LOKVESSMR4R_RS05110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LOKVESSMR4R_RS05125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LOKVESSMR4R_RS05130	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS05135	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS05145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LOKVESSMR4R_RS05155	COG1802	Transcriptional regulator
LOKVESSMR4R_RS05165	COG0505	Belongs to the CarA family
LOKVESSMR4R_RS05190	COG0154	amidase activity
LOKVESSMR4R_RS05195	COG0321	lipoyl(octanoyl) transferase activity
LOKVESSMR4R_RS05210	COG2951	lytic endotransglycosylase activity
LOKVESSMR4R_RS05235	COG1091	dTDP-4-dehydrorhamnose reductase activity
LOKVESSMR4R_RS05245	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LOKVESSMR4R_RS05250	COG1850	ribulose-bisphosphate carboxylase activity
LOKVESSMR4R_RS05260	COG0287	Prephenate dehydrogenase
LOKVESSMR4R_RS05270	COG1129	ABC transporter
LOKVESSMR4R_RS05285	COG3386	PFAM SMP-30 Gluconolaconase
LOKVESSMR4R_RS05295	COG2186	Transcriptional regulator
LOKVESSMR4R_RS05305	COG0019	diaminopimelate decarboxylase activity
LOKVESSMR4R_RS05325	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS05340	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_RS05350	COG3842	ATPase activity
LOKVESSMR4R_RS05355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKVESSMR4R_RS05375	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS05375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_RS05385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LOKVESSMR4R_RS05390	COG1760	l-serine dehydratase
LOKVESSMR4R_RS05430	COG1309	transcriptional regulator
LOKVESSMR4R_RS05450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LOKVESSMR4R_RS05470	COG3547	Transposase (IS116 IS110 IS902 family)
LOKVESSMR4R_RS05475	COG2223	nitrite transmembrane transporter activity
LOKVESSMR4R_RS05480	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LOKVESSMR4R_RS05485	COG1140	nitrate reductase beta subunit
LOKVESSMR4R_RS05490	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LOKVESSMR4R_RS05495	COG2181	nitrate reductase activity
LOKVESSMR4R_RS05510	COG0288	reversible hydration of carbon dioxide
LOKVESSMR4R_RS05515	COG0303	'Molybdopterin
LOKVESSMR4R_RS05520	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS05520	COG1618	nucleotide phosphatase activity, acting on free nucleotides
LOKVESSMR4R_RS05530	COG2948	multi-organism process
LOKVESSMR4R_RS05545	COG3846	protein secretion by the type IV secretion system
LOKVESSMR4R_RS05590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LOKVESSMR4R_RS05595	COG0730	response to heat
LOKVESSMR4R_RS05605	COG2378	regulation of single-species biofilm formation
LOKVESSMR4R_RS05610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LOKVESSMR4R_RS05620	COG0805	protein transport
LOKVESSMR4R_RS05635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LOKVESSMR4R_RS05640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LOKVESSMR4R_RS05645	COG4221	oxidoreductase activity
LOKVESSMR4R_RS05650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LOKVESSMR4R_RS05670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LOKVESSMR4R_RS05680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LOKVESSMR4R_RS05685	COG0418	dihydroorotase activity
LOKVESSMR4R_RS05690	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS05695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKVESSMR4R_RS05705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LOKVESSMR4R_RS05735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LOKVESSMR4R_RS05760	COG0175	sulfate reduction
LOKVESSMR4R_RS05765	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LOKVESSMR4R_RS05780	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS05795	COG0149	triose-phosphate isomerase activity
LOKVESSMR4R_RS05810	COG2151	metal-sulfur cluster biosynthetic enzyme
LOKVESSMR4R_RS05815	COG0343	queuine tRNA-ribosyltransferase activity
LOKVESSMR4R_RS05820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LOKVESSMR4R_RS05870	COG0156	8-amino-7-oxononanoate synthase activity
LOKVESSMR4R_RS05880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LOKVESSMR4R_RS05885	COG0436	Aminotransferase
LOKVESSMR4R_RS05895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LOKVESSMR4R_RS05900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LOKVESSMR4R_RS05915	COG3347	Dehydrogenase
LOKVESSMR4R_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS05930	COG1129	ABC transporter
LOKVESSMR4R_RS05935	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS05940	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS05945	COG3254	rhamnose metabolic process
LOKVESSMR4R_RS05960	COG0739	heme binding
LOKVESSMR4R_RS05965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LOKVESSMR4R_RS05975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LOKVESSMR4R_RS05990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LOKVESSMR4R_RS05995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LOKVESSMR4R_RS06010	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS06025	COG0517	IMP dehydrogenase activity
LOKVESSMR4R_RS06025	COG0516	GMP reductase activity
LOKVESSMR4R_RS06030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LOKVESSMR4R_RS06050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LOKVESSMR4R_RS06065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LOKVESSMR4R_RS06075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOKVESSMR4R_RS06095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LOKVESSMR4R_RS06100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LOKVESSMR4R_RS06105	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LOKVESSMR4R_RS06130	COG3088	subunit of a heme lyase
LOKVESSMR4R_RS06135	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_RS06150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKVESSMR4R_RS06155	COG0658	competence protein
LOKVESSMR4R_RS06155	COG2333	competence protein COMEC
LOKVESSMR4R_RS06160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LOKVESSMR4R_RS06165	COG0303	'Molybdopterin
LOKVESSMR4R_RS06170	COG0315	cyclic pyranopterin monophosphate synthase activity
LOKVESSMR4R_RS06175	COG0134	indole-3-glycerol-phosphate synthase activity
LOKVESSMR4R_RS06180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LOKVESSMR4R_RS06185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LOKVESSMR4R_RS06200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LOKVESSMR4R_RS06210	COG0436	Aminotransferase
LOKVESSMR4R_RS06215	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LOKVESSMR4R_RS06220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LOKVESSMR4R_RS06225	COG0259	pyridoxamine-phosphate oxidase activity
LOKVESSMR4R_RS06230	COG1278	Cold shock
LOKVESSMR4R_RS06245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LOKVESSMR4R_RS06255	COG0148	phosphopyruvate hydratase activity
LOKVESSMR4R_RS06260	COG0697	spore germination
LOKVESSMR4R_RS06270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LOKVESSMR4R_RS06275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LOKVESSMR4R_RS06285	COG0215	cysteine-tRNA ligase activity
LOKVESSMR4R_RS06290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LOKVESSMR4R_RS06300	COG2814	Major facilitator Superfamily
LOKVESSMR4R_RS06305	COG1797	cobyrinic acid a,c-diamide synthase activity
LOKVESSMR4R_RS06335	COG1943	Transposase
LOKVESSMR4R_RS06345	COG4651	solute:proton antiporter activity
LOKVESSMR4R_RS06345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LOKVESSMR4R_RS06350	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LOKVESSMR4R_RS06360	COG0166	Belongs to the GPI family
LOKVESSMR4R_RS06370	COG0251	oxidation-reduction process
LOKVESSMR4R_RS06415	COG1609	Transcriptional regulator
LOKVESSMR4R_RS06420	COG1653	transport
LOKVESSMR4R_RS06425	COG1175	transmembrane transport
LOKVESSMR4R_RS06430	COG0395	ABC-type sugar transport system, permease component
LOKVESSMR4R_RS06435	COG0366	Alpha amylase catalytic
LOKVESSMR4R_RS06440	COG3842	ATPase activity
LOKVESSMR4R_RS06455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LOKVESSMR4R_RS06465	COG0248	Ppx GppA phosphatase
LOKVESSMR4R_RS06470	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LOKVESSMR4R_RS06480	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LOKVESSMR4R_RS06485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOKVESSMR4R_RS06495	COG1217	gtp-binding protein TYPA
LOKVESSMR4R_RS06500	COG2076	Multidrug Resistance protein
LOKVESSMR4R_RS06515	COG0538	isocitrate dehydrogenase activity
LOKVESSMR4R_RS06525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LOKVESSMR4R_RS06530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LOKVESSMR4R_RS06535	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LOKVESSMR4R_RS06540	COG2166	iron-sulfur cluster assembly
LOKVESSMR4R_RS06555	COG5012	cobalamin binding
LOKVESSMR4R_RS06565	COG0646	methionine synthase
LOKVESSMR4R_RS06565	COG1410	methionine synthase
LOKVESSMR4R_RS06575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LOKVESSMR4R_RS06580	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LOKVESSMR4R_RS06585	COG0047	phosphoribosylformylglycinamidine synthase activity
LOKVESSMR4R_RS06595	COG2204	response regulator
LOKVESSMR4R_RS06600	COG1530	ribonuclease E activity
LOKVESSMR4R_RS06605	COG0425	Belongs to the sulfur carrier protein TusA family
LOKVESSMR4R_RS06610	COG0785	Cytochrome C biogenesis protein
LOKVESSMR4R_RS06620	COG2124	cytochrome p450
LOKVESSMR4R_RS06640	COG0114	fumarate hydratase activity
LOKVESSMR4R_RS06675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOKVESSMR4R_RS06680	COG1999	signal sequence binding
LOKVESSMR4R_RS06710	COG0604	alcohol dehydrogenase
LOKVESSMR4R_RS06720	COG0415	Belongs to the DNA photolyase family
LOKVESSMR4R_RS06725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LOKVESSMR4R_RS06740	COG3264	Mechanosensitive ion channel
LOKVESSMR4R_RS06740	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LOKVESSMR4R_RS06745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LOKVESSMR4R_RS06755	COG0628	permease
LOKVESSMR4R_RS06765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LOKVESSMR4R_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS06820	COG1320	monovalent cation:proton antiporter activity
LOKVESSMR4R_RS06825	COG2212	antiporter activity
LOKVESSMR4R_RS06830	COG1863	multisubunit Na H antiporter MnhE subunit
LOKVESSMR4R_RS06835	COG0651	ATP synthesis coupled electron transport
LOKVESSMR4R_RS06840	COG1006	Multisubunit Na H antiporter MnhC subunit
LOKVESSMR4R_RS06845	COG2111	Na H antiporter
LOKVESSMR4R_RS06850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LOKVESSMR4R_RS06850	COG2111	Na H antiporter
LOKVESSMR4R_RS06855	COG3108	Peptidase M15
LOKVESSMR4R_RS06860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKVESSMR4R_RS06880	COG4536	flavin adenine dinucleotide binding
LOKVESSMR4R_RS06885	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS06900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LOKVESSMR4R_RS06905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LOKVESSMR4R_RS06915	COG0629	single-stranded DNA binding
LOKVESSMR4R_RS06925	COG3292	Two component regulator propeller
LOKVESSMR4R_RS06925	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS06925	COG2205	protein histidine kinase activity
LOKVESSMR4R_RS06930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LOKVESSMR4R_RS06935	COG0528	UMP kinase activity
LOKVESSMR4R_RS06940	COG0233	cytoplasmic translational termination
LOKVESSMR4R_RS06945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LOKVESSMR4R_RS06955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LOKVESSMR4R_RS06960	COG0750	zinc metalloprotease
LOKVESSMR4R_RS06965	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LOKVESSMR4R_RS06975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LOKVESSMR4R_RS06980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKVESSMR4R_RS06990	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LOKVESSMR4R_RS07005	COG0697	spore germination
LOKVESSMR4R_RS07010	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_RS07050	COG2308	Evidence 4 Homologs of previously reported genes of
LOKVESSMR4R_RS07070	COG1902	pentaerythritol trinitrate reductase activity
LOKVESSMR4R_RS07070	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS07105	COG3743	rRNA binding
LOKVESSMR4R_RS07105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LOKVESSMR4R_RS07110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LOKVESSMR4R_RS07120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LOKVESSMR4R_RS07125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LOKVESSMR4R_RS07165	COG1612	heme a metabolic process
LOKVESSMR4R_RS07170	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LOKVESSMR4R_RS07190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKVESSMR4R_RS07195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LOKVESSMR4R_RS07200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LOKVESSMR4R_RS07205	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_RS07210	COG1177	transmembrane transport
LOKVESSMR4R_RS07215	COG3842	ATPase activity
LOKVESSMR4R_RS07225	COG1309	transcriptional regulator
LOKVESSMR4R_RS07235	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LOKVESSMR4R_RS07250	COG0482	sulfurtransferase activity
LOKVESSMR4R_RS07265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LOKVESSMR4R_RS07270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LOKVESSMR4R_RS07280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LOKVESSMR4R_RS07285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LOKVESSMR4R_RS07290	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LOKVESSMR4R_RS07295	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LOKVESSMR4R_RS07300	COG2423	ornithine cyclodeaminase activity
LOKVESSMR4R_RS07305	COG0010	Belongs to the arginase family
LOKVESSMR4R_RS07320	COG1238	metal cluster binding
LOKVESSMR4R_RS07370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LOKVESSMR4R_RS07375	COG2814	Major facilitator Superfamily
LOKVESSMR4R_RS07390	COG4166	transmembrane transport
LOKVESSMR4R_RS07395	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS07415	COG2313	pseudouridylate synthase activity
LOKVESSMR4R_RS07435	COG0052	Belongs to the universal ribosomal protein uS2 family
LOKVESSMR4R_RS07440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LOKVESSMR4R_RS07445	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LOKVESSMR4R_RS07470	COG0704	Plays a role in the regulation of phosphate uptake
LOKVESSMR4R_RS07490	COG0194	GDP metabolic process
LOKVESSMR4R_RS07495	COG1561	YicC-like family, N-terminal region
LOKVESSMR4R_RS07505	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LOKVESSMR4R_RS07550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LOKVESSMR4R_RS07555	COG1923	regulation of RNA biosynthetic process
LOKVESSMR4R_RS07565	COG0569	domain protein
LOKVESSMR4R_RS07570	COG2204	response regulator
LOKVESSMR4R_RS07575	COG5000	phosphorelay sensor kinase activity
LOKVESSMR4R_RS07580	COG2204	response regulator
LOKVESSMR4R_RS07585	COG3852	Histidine kinase
LOKVESSMR4R_RS07590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LOKVESSMR4R_RS07595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LOKVESSMR4R_RS07595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LOKVESSMR4R_RS07600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LOKVESSMR4R_RS07605	COG1546	Belongs to the CinA family
LOKVESSMR4R_RS07615	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LOKVESSMR4R_RS07645	COG0519	Catalyzes the synthesis of GMP from XMP
LOKVESSMR4R_RS07645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LOKVESSMR4R_RS07660	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS07665	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS07670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS07680	COG0747	negative chemotaxis
LOKVESSMR4R_RS07695	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LOKVESSMR4R_RS07755	COG4372	Transposase
LOKVESSMR4R_RS07760	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS07765	COG2963	transposase activity
LOKVESSMR4R_RS07785	COG0250	Participates in transcription elongation, termination and antitermination
LOKVESSMR4R_RS07835	COG1083	cytidylyl-transferase
LOKVESSMR4R_RS07850	COG0662	Cupin 2, conserved barrel domain protein
LOKVESSMR4R_RS07850	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LOKVESSMR4R_RS07855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LOKVESSMR4R_RS07860	COG1088	dTDP-glucose 4,6-dehydratase activity
LOKVESSMR4R_RS07870	COG0297	glycogen (starch) synthase activity
LOKVESSMR4R_RS07880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LOKVESSMR4R_RS07905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOKVESSMR4R_RS07955	COG0719	Fe-S assembly protein
LOKVESSMR4R_RS07960	COG0396	ATPase activity
LOKVESSMR4R_RS07965	COG0719	Fe-S assembly protein
LOKVESSMR4R_RS07980	COG2945	thiolester hydrolase activity
LOKVESSMR4R_RS07990	COG0513	Belongs to the DEAD box helicase family
LOKVESSMR4R_RS08010	COG0105	UTP biosynthetic process
LOKVESSMR4R_RS08015	COG0488	(ABC) transporter
LOKVESSMR4R_RS08020	COG2095	MarC family integral membrane protein
LOKVESSMR4R_RS08025	COG3577	Aspartyl protease
LOKVESSMR4R_RS08035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOKVESSMR4R_RS08060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LOKVESSMR4R_RS08065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LOKVESSMR4R_RS08075	COG2890	protein-(glutamine-N5) methyltransferase activity
LOKVESSMR4R_RS08080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LOKVESSMR4R_RS08095	COG0010	Belongs to the arginase family
LOKVESSMR4R_RS08105	COG3956	TIGRFAM MazG family protein
LOKVESSMR4R_RS08110	COG1840	ABC-type Fe3 transport system, periplasmic component
LOKVESSMR4R_RS08120	COG0488	(ABC) transporter
LOKVESSMR4R_RS08130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LOKVESSMR4R_RS08145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LOKVESSMR4R_RS08150	COG0416	fatty acid biosynthetic process
LOKVESSMR4R_RS08155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LOKVESSMR4R_RS08160	COG0776	regulation of translation
LOKVESSMR4R_RS08175	COG0717	Belongs to the dCTP deaminase family
LOKVESSMR4R_RS08180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LOKVESSMR4R_RS08185	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LOKVESSMR4R_RS08190	COG1472	Belongs to the glycosyl hydrolase 3 family
LOKVESSMR4R_RS08200	COG0018	arginyl-trna synthetase
LOKVESSMR4R_RS08205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LOKVESSMR4R_RS08210	COG0316	Belongs to the HesB IscA family
LOKVESSMR4R_RS08250	COG0501	Belongs to the peptidase M48B family
LOKVESSMR4R_RS08260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LOKVESSMR4R_RS08270	COG0129	dihydroxy-acid dehydratase activity
LOKVESSMR4R_RS08275	COG0800	Aldolase
LOKVESSMR4R_RS08280	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_RS08290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LOKVESSMR4R_RS08305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LOKVESSMR4R_RS08310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKVESSMR4R_RS08320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKVESSMR4R_RS08340	COG0625	glutathione transferase activity
LOKVESSMR4R_RS08350	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_RS08355	COG0440	acetolactate synthase activity
LOKVESSMR4R_RS08370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LOKVESSMR4R_RS08390	COG1830	Aldolase
LOKVESSMR4R_RS08400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LOKVESSMR4R_RS08405	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_RS08405	COG0022	dehydrogenase e1 component
LOKVESSMR4R_RS08410	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_RS08495	COG4695	Portal protein
LOKVESSMR4R_RS08510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LOKVESSMR4R_RS08515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOKVESSMR4R_RS08520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOKVESSMR4R_RS08530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LOKVESSMR4R_RS08545	COG2353	YceI-like domain
LOKVESSMR4R_RS08550	COG0360	Binds together with S18 to 16S ribosomal RNA
LOKVESSMR4R_RS08555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LOKVESSMR4R_RS08560	COG0359	binds to the 23S rRNA
LOKVESSMR4R_RS08575	COG0544	peptidyl-prolyl cis-trans isomerase activity
LOKVESSMR4R_RS08585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LOKVESSMR4R_RS08585	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LOKVESSMR4R_RS08615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LOKVESSMR4R_RS08660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LOKVESSMR4R_RS08665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKVESSMR4R_RS08675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LOKVESSMR4R_RS08680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LOKVESSMR4R_RS08685	COG4133	protoheme IX ABC transporter activity
LOKVESSMR4R_RS08690	COG3737	Protein of unknown function (DUF498/DUF598)
LOKVESSMR4R_RS08695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LOKVESSMR4R_RS08700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LOKVESSMR4R_RS08705	COG1862	Preprotein translocase
LOKVESSMR4R_RS08710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LOKVESSMR4R_RS08720	COG1160	GTP binding
LOKVESSMR4R_RS08740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKVESSMR4R_RS08745	COG5265	(ABC) transporter
LOKVESSMR4R_RS08775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_RS08775	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS08790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_RS08795	COG4235	cytochrome complex assembly
LOKVESSMR4R_RS08800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LOKVESSMR4R_RS08810	COG3842	ATPase activity
LOKVESSMR4R_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS08835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LOKVESSMR4R_RS08855	COG0513	Belongs to the DEAD box helicase family
LOKVESSMR4R_RS08865	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LOKVESSMR4R_RS08875	COG1007	ATP synthesis coupled electron transport
LOKVESSMR4R_RS08890	COG0713	ATP synthesis coupled electron transport
LOKVESSMR4R_RS08905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOKVESSMR4R_RS08910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LOKVESSMR4R_RS08945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LOKVESSMR4R_RS08945	COG3743	rRNA binding
LOKVESSMR4R_RS08965	COG0649	NAD binding
LOKVESSMR4R_RS08975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOKVESSMR4R_RS08980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LOKVESSMR4R_RS09005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LOKVESSMR4R_RS09020	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS09025	COG0546	phosphoglycolate phosphatase activity
LOKVESSMR4R_RS09030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LOKVESSMR4R_RS09035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LOKVESSMR4R_RS09045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LOKVESSMR4R_RS09055	COG1473	amidohydrolase
LOKVESSMR4R_RS09075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LOKVESSMR4R_RS09100	COG1295	ribonuclease BN
LOKVESSMR4R_RS09120	COG1175	transmembrane transport
LOKVESSMR4R_RS09130	COG1404	Belongs to the peptidase S8 family
LOKVESSMR4R_RS09155	COG1294	oxidase, subunit
LOKVESSMR4R_RS09160	COG1271	oxidase subunit
LOKVESSMR4R_RS09165	COG1959	2 iron, 2 sulfur cluster binding
LOKVESSMR4R_RS09170	COG4604	ABC transporter, ATP-binding protein
LOKVESSMR4R_RS09175	COG4605	iron ion homeostasis
LOKVESSMR4R_RS09180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOKVESSMR4R_RS09185	COG4607	ABC-type enterochelin transport system periplasmic component
LOKVESSMR4R_RS09195	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS09200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_RS09205	COG4771	TonB-dependent receptor
LOKVESSMR4R_RS09210	COG0747	negative chemotaxis
LOKVESSMR4R_RS09215	COG0601	transmembrane transport
LOKVESSMR4R_RS09220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS09225	COG4172	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS09255	COG0573	inorganic phosphate transmembrane transporter activity
LOKVESSMR4R_RS09260	COG0581	inorganic phosphate transmembrane transporter activity
LOKVESSMR4R_RS09265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LOKVESSMR4R_RS09270	COG0704	Plays a role in the regulation of phosphate uptake
LOKVESSMR4R_RS09275	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS09280	COG1312	Catalyzes the dehydration of D-mannonate
LOKVESSMR4R_RS09285	COG2721	sulfolactate sulfo-lyase activity
LOKVESSMR4R_RS09290	COG0246	Mannitol dehydrogenase
LOKVESSMR4R_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS09300	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LOKVESSMR4R_RS09305	COG1917	Cupin 2, conserved barrel domain protein
LOKVESSMR4R_RS09320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKVESSMR4R_RS09325	COG1904	glucuronate isomerase
LOKVESSMR4R_RS09345	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS09365	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS09370	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS09375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS09380	COG0601	transmembrane transport
LOKVESSMR4R_RS09405	COG0811	peptide transport
LOKVESSMR4R_RS09415	COG1629	transport
LOKVESSMR4R_RS09420	COG3720	iron ion transport
LOKVESSMR4R_RS09425	COG4558	Periplasmic binding protein
LOKVESSMR4R_RS09430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LOKVESSMR4R_RS09435	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS09460	COG1595	DNA-templated transcription, initiation
LOKVESSMR4R_RS09470	COG3220	belongs to the UPF0276 family
LOKVESSMR4R_RS09485	COG3920	Histidine kinase
LOKVESSMR4R_RS09490	COG2226	methyltransferase
LOKVESSMR4R_RS09495	COG0702	epimerase
LOKVESSMR4R_RS09500	COG1733	regulation of RNA biosynthetic process
LOKVESSMR4R_RS09540	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS09555	COG0033	Phosphoglucomutase
LOKVESSMR4R_RS09585	COG3842	ATPase activity
LOKVESSMR4R_RS09595	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_RS09610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LOKVESSMR4R_RS09610	COG0321	lipoyl(octanoyl) transferase activity
LOKVESSMR4R_RS09615	COG0084	hydrolase, TatD family'
LOKVESSMR4R_RS09625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LOKVESSMR4R_RS09630	COG1686	Belongs to the peptidase S11 family
LOKVESSMR4R_RS09650	COG0154	amidase activity
LOKVESSMR4R_RS09655	COG4608	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS09660	COG0444	Belongs to the ABC transporter superfamily
LOKVESSMR4R_RS09665	COG0601	transmembrane transport
LOKVESSMR4R_RS09670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS09675	COG0747	negative chemotaxis
LOKVESSMR4R_RS09690	COG3454	Phosphonate metabolism
LOKVESSMR4R_RS09695	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LOKVESSMR4R_RS09705	COG4778	phosphonate C-P lyase system protein PhnL
LOKVESSMR4R_RS09710	COG4107	phosphonate C-P lyase system protein PhnK
LOKVESSMR4R_RS09715	COG3627	carbon phosphorus lyase activity
LOKVESSMR4R_RS09720	COG3626	phosphonate metabolism
LOKVESSMR4R_RS09735	COG2188	Transcriptional regulator
LOKVESSMR4R_RS09740	COG3454	Phosphonate metabolism
LOKVESSMR4R_RS09750	COG3639	organic phosphonate transmembrane transporter activity
LOKVESSMR4R_RS09755	COG3639	organic phosphonate transmembrane transporter activity
LOKVESSMR4R_RS09760	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LOKVESSMR4R_RS09765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS09780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LOKVESSMR4R_RS09795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LOKVESSMR4R_RS09795	COG3218	ABC-type transport auxiliary lipoprotein component
LOKVESSMR4R_RS09800	COG1127	ABC transporter
LOKVESSMR4R_RS09805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LOKVESSMR4R_RS09835	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_RS09860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKVESSMR4R_RS09870	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS09875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LOKVESSMR4R_RS09880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LOKVESSMR4R_RS09885	COG4989	oxidoreductase activity
LOKVESSMR4R_RS09905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKVESSMR4R_RS09930	COG2115	Belongs to the xylose isomerase family
LOKVESSMR4R_RS09935	COG1070	Carbohydrate kinase
LOKVESSMR4R_RS09945	COG4214	carbohydrate transport
LOKVESSMR4R_RS09950	COG4213	ABC transporter substrate-binding protein
LOKVESSMR4R_RS09955	COG1940	carbohydrate kinase activity
LOKVESSMR4R_RS09965	COG1858	cytochrome C peroxidase
LOKVESSMR4R_RS10000	COG1178	ABC-type Fe3 transport system permease component
LOKVESSMR4R_RS10010	COG3750	Belongs to the UPF0335 family
LOKVESSMR4R_RS10025	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS10040	COG2391	methyltransferase activity
LOKVESSMR4R_RS10070	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS10085	COG0511	ligase activity, forming carbon-carbon bonds
LOKVESSMR4R_RS10090	COG0439	Biotin carboxylase
LOKVESSMR4R_RS10095	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LOKVESSMR4R_RS10110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LOKVESSMR4R_RS10115	COG0740	serine-type endopeptidase activity
LOKVESSMR4R_RS10120	COG1469	GTP cyclohydrolase I activity
LOKVESSMR4R_RS10130	COG2917	probably involved in intracellular septation
LOKVESSMR4R_RS10140	COG0552	protein localization to endoplasmic reticulum
LOKVESSMR4R_RS10175	COG1329	Transcriptional regulator
LOKVESSMR4R_RS10180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LOKVESSMR4R_RS10185	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LOKVESSMR4R_RS10215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LOKVESSMR4R_RS10215	COG1793	dna ligase
LOKVESSMR4R_RS10235	COG0564	pseudouridine synthase activity
LOKVESSMR4R_RS10265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LOKVESSMR4R_RS10270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LOKVESSMR4R_RS10275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LOKVESSMR4R_RS10275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LOKVESSMR4R_RS10300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LOKVESSMR4R_RS10300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LOKVESSMR4R_RS10310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LOKVESSMR4R_RS10315	COG0358	DNA primase activity
LOKVESSMR4R_RS10325	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS10325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LOKVESSMR4R_RS10335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_RS10340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LOKVESSMR4R_RS10385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LOKVESSMR4R_RS10400	COG1846	Transcriptional regulator
LOKVESSMR4R_RS10425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOKVESSMR4R_RS10430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKVESSMR4R_RS10445	COG1363	Peptidase, m42
LOKVESSMR4R_RS10455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LOKVESSMR4R_RS10465	COG1496	oxidoreductase activity
LOKVESSMR4R_RS10475	COG0534	Mate efflux family protein
LOKVESSMR4R_RS10500	COG0187	DNA topoisomerase II activity
LOKVESSMR4R_RS10510	COG2010	Cytochrome c
LOKVESSMR4R_RS10520	COG1136	(ABC) transporter
LOKVESSMR4R_RS10530	COG0442	prolyl-tRNA aminoacylation
LOKVESSMR4R_RS10535	COG0628	permease
LOKVESSMR4R_RS10545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LOKVESSMR4R_RS10550	COG0248	Ppx GppA phosphatase
LOKVESSMR4R_RS10555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LOKVESSMR4R_RS10565	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LOKVESSMR4R_RS10565	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LOKVESSMR4R_RS10575	COG4770	biotin carboxylase activity
LOKVESSMR4R_RS10590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LOKVESSMR4R_RS10600	COG1396	sequence-specific DNA binding
LOKVESSMR4R_RS10600	COG3800	Transcriptional regulator
LOKVESSMR4R_RS10625	COG3119	arylsulfatase activity
LOKVESSMR4R_RS10630	COG1309	transcriptional regulator
LOKVESSMR4R_RS10645	COG4175	Glycine betaine
LOKVESSMR4R_RS10655	COG1692	metallophosphoesterase
LOKVESSMR4R_RS10665	COG3273	potassium ion transport
LOKVESSMR4R_RS10665	COG0471	metal ion transport
LOKVESSMR4R_RS10670	COG0217	transcriptional regulatory protein
LOKVESSMR4R_RS10675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LOKVESSMR4R_RS10680	COG2239	Acts as a magnesium transporter
LOKVESSMR4R_RS10685	COG0402	S-adenosylhomocysteine deaminase activity
LOKVESSMR4R_RS10690	COG0483	inositol monophosphate 1-phosphatase activity
LOKVESSMR4R_RS10695	COG1396	sequence-specific DNA binding
LOKVESSMR4R_RS10705	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS10715	COG0670	Belongs to the BI1 family
LOKVESSMR4R_RS10720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LOKVESSMR4R_RS10735	COG3023	N-Acetylmuramoyl-L-alanine amidase
LOKVESSMR4R_RS10745	COG0154	amidase activity
LOKVESSMR4R_RS10750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LOKVESSMR4R_RS10760	COG0590	tRNA wobble adenosine to inosine editing
LOKVESSMR4R_RS10765	COG1187	pseudouridine synthase activity
LOKVESSMR4R_RS10815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LOKVESSMR4R_RS10820	COG1121	(ABC) transporter
LOKVESSMR4R_RS10825	COG0735	belongs to the Fur family
LOKVESSMR4R_RS10830	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LOKVESSMR4R_RS10895	COG0667	Aldo Keto reductase
LOKVESSMR4R_RS10905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LOKVESSMR4R_RS10910	COG1083	cytidylyl-transferase
LOKVESSMR4R_RS10920	COG2089	acid synthase
LOKVESSMR4R_RS10940	COG0012	GTP binding
LOKVESSMR4R_RS10945	COG0159	tryptophan synthase activity
LOKVESSMR4R_RS10975	COG0193	aminoacyl-tRNA hydrolase activity
LOKVESSMR4R_RS10990	COG0133	tryptophan synthase activity
LOKVESSMR4R_RS10995	COG0135	phosphoribosylanthranilate isomerase activity
LOKVESSMR4R_RS11005	COG0776	regulation of translation
LOKVESSMR4R_RS11010	COG0539	negative regulation of cytoplasmic translation
LOKVESSMR4R_RS11020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LOKVESSMR4R_RS11025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LOKVESSMR4R_RS11030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LOKVESSMR4R_RS11035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LOKVESSMR4R_RS11040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LOKVESSMR4R_RS11045	COG1253	flavin adenine dinucleotide binding
LOKVESSMR4R_RS11050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LOKVESSMR4R_RS11055	COG1702	phosphate starvation-inducible protein PhoH
LOKVESSMR4R_RS11060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKVESSMR4R_RS11070	COG1943	Transposase
LOKVESSMR4R_RS11090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LOKVESSMR4R_RS11095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LOKVESSMR4R_RS11100	COG1047	Peptidyl-prolyl cis-trans
LOKVESSMR4R_RS11145	COG3773	Cell wall hydrolase
LOKVESSMR4R_RS11160	COG0110	maltose O-acetyltransferase activity
LOKVESSMR4R_RS11165	COG0297	glycogen (starch) synthase activity
LOKVESSMR4R_RS11200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LOKVESSMR4R_RS11205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LOKVESSMR4R_RS11210	COG0725	ABC transporter, periplasmic molybdate-binding protein
LOKVESSMR4R_RS11215	COG4149	molybdate abc transporter
LOKVESSMR4R_RS11220	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS11240	COG1834	amidinotransferase
LOKVESSMR4R_RS11245	COG1309	transcriptional regulator
LOKVESSMR4R_RS11265	COG3246	L-lysine catabolic process to acetate
LOKVESSMR4R_RS11270	COG0824	Thioesterase
LOKVESSMR4R_RS11270	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_RS11275	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS11285	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_RS11290	COG3685	Protein conserved in bacteria
LOKVESSMR4R_RS11300	COG2323	membrane
LOKVESSMR4R_RS11360	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS11370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKVESSMR4R_RS11380	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS11385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKVESSMR4R_RS11390	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_RS11400	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS11450	COG1196	nuclear chromosome segregation
LOKVESSMR4R_RS11450	COG0741	lytic transglycosylase activity
LOKVESSMR4R_RS11450	COG0739	heme binding
LOKVESSMR4R_RS11465	COG0556	nucleotide-excision repair
LOKVESSMR4R_RS11490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_RS11495	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_RS11510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LOKVESSMR4R_RS11530	COG0028	Belongs to the TPP enzyme family
LOKVESSMR4R_RS11545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LOKVESSMR4R_RS11550	COG0243	molybdopterin cofactor binding
LOKVESSMR4R_RS11555	COG0437	4 iron, 4 sulfur cluster binding
LOKVESSMR4R_RS11565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_RS11575	COG1414	Transcriptional regulator
LOKVESSMR4R_RS11585	COG1175	transmembrane transport
LOKVESSMR4R_RS11590	COG0395	ABC-type sugar transport system, permease component
LOKVESSMR4R_RS11600	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS11605	COG3734	2-keto-3-deoxy-galactonokinase
LOKVESSMR4R_RS11610	COG0800	Aldolase
LOKVESSMR4R_RS11615	COG3386	PFAM SMP-30 Gluconolaconase
LOKVESSMR4R_RS11630	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LOKVESSMR4R_RS11635	COG0709	Synthesizes selenophosphate from selenide and ATP
LOKVESSMR4R_RS11640	COG0259	pyridoxamine-phosphate oxidase activity
LOKVESSMR4R_RS11650	COG0577	efflux transmembrane transporter activity
LOKVESSMR4R_RS11655	COG1136	(ABC) transporter
LOKVESSMR4R_RS11660	COG0183	Belongs to the thiolase family
LOKVESSMR4R_RS11670	COG3022	response to hydroperoxide
LOKVESSMR4R_RS11685	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LOKVESSMR4R_RS11690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LOKVESSMR4R_RS11695	COG1940	carbohydrate kinase activity
LOKVESSMR4R_RS11705	COG0037	tRNA processing
LOKVESSMR4R_RS11715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LOKVESSMR4R_RS11720	COG0594	ribonuclease P activity
LOKVESSMR4R_RS11725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LOKVESSMR4R_RS11735	COG4251	negative regulation of phosphorylation
LOKVESSMR4R_RS11850	COG0582	viral genome integration into host DNA
LOKVESSMR4R_RS11920	COG0582	viral genome integration into host DNA
LOKVESSMR4R_RS11940	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS12010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKVESSMR4R_RS12015	COG2274	protein secretion by the type I secretion system
LOKVESSMR4R_RS12040	COG2909	trisaccharide binding
LOKVESSMR4R_RS12045	COG0601	transmembrane transport
LOKVESSMR4R_RS12050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS12095	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LOKVESSMR4R_RS12105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOKVESSMR4R_RS12120	COG1335	isochorismatase
LOKVESSMR4R_RS12125	COG0778	Nitroreductase
LOKVESSMR4R_RS12130	COG0154	amidase activity
LOKVESSMR4R_RS12140	COG1129	ABC transporter
LOKVESSMR4R_RS12155	COG2188	Transcriptional regulator
LOKVESSMR4R_RS12160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LOKVESSMR4R_RS12165	COG0154	amidase activity
LOKVESSMR4R_RS12170	COG0154	amidase activity
LOKVESSMR4R_RS12175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LOKVESSMR4R_RS12195	COG1215	transferase activity, transferring glycosyl groups
LOKVESSMR4R_RS12200	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS12210	COG1070	Carbohydrate kinase
LOKVESSMR4R_RS12255	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_RS12270	COG3842	ATPase activity
LOKVESSMR4R_RS12285	COG1760	l-serine dehydratase
LOKVESSMR4R_RS12290	COG2423	ornithine cyclodeaminase activity
LOKVESSMR4R_RS12295	COG3616	Alanine racemase, N-terminal domain
LOKVESSMR4R_RS12300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_RS12335	COG0659	secondary active sulfate transmembrane transporter activity
LOKVESSMR4R_RS12345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LOKVESSMR4R_RS12345	COG0316	Belongs to the HesB IscA family
LOKVESSMR4R_RS12350	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_RS12355	COG1846	Transcriptional regulator
LOKVESSMR4R_RS12365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_RS12370	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_RS12375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LOKVESSMR4R_RS12380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKVESSMR4R_RS12395	COG2022	thiamine diphosphate biosynthetic process
LOKVESSMR4R_RS12410	COG0351	phosphomethylpyrimidine kinase
LOKVESSMR4R_RS12430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LOKVESSMR4R_RS12435	COG1609	Transcriptional regulator
LOKVESSMR4R_RS12440	COG1879	ABC-type sugar transport system periplasmic component
LOKVESSMR4R_RS12445	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS12450	COG1129	ABC transporter
LOKVESSMR4R_RS12460	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS12470	COG2963	transposase activity
LOKVESSMR4R_RS12475	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS12480	COG4372	Transposase
LOKVESSMR4R_RS12535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LOKVESSMR4R_RS12615	COG1309	transcriptional regulator
LOKVESSMR4R_RS12655	COG3833	ABC-type maltose transport systems, permease component
LOKVESSMR4R_RS12660	COG3842	ATPase activity
LOKVESSMR4R_RS12665	COG0584	glycerophosphoryl diester phosphodiesterase
LOKVESSMR4R_RS12680	COG1475	DNA binding
LOKVESSMR4R_RS12905	COG1061	Type III restriction enzyme res subunit
LOKVESSMR4R_RS12910	COG1002	Type II restriction enzyme, methylase subunits
LOKVESSMR4R_RS12930	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS12945	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS12950	COG1129	ABC transporter
LOKVESSMR4R_RS12965	COG3185	4-Hydroxyphenylpyruvate dioxygenase
LOKVESSMR4R_RS12965	COG1082	Xylose isomerase domain protein TIM barrel
LOKVESSMR4R_RS12970	COG1940	carbohydrate kinase activity
LOKVESSMR4R_RS12985	COG2925	Exonuclease
LOKVESSMR4R_RS12990	COG3177	Filamentation induced by cAMP protein fic
LOKVESSMR4R_RS13060	COG0523	cobalamin synthesis protein
LOKVESSMR4R_RS13085	COG1122	ATPase activity
LOKVESSMR4R_RS13115	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS13120	COG0506	proline dehydrogenase activity
LOKVESSMR4R_RS13120	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LOKVESSMR4R_RS13120	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LOKVESSMR4R_RS13130	COG0483	inositol monophosphate 1-phosphatase activity
LOKVESSMR4R_RS13135	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS13160	COG0525	valine-tRNA ligase activity
LOKVESSMR4R_RS13165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LOKVESSMR4R_RS13170	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LOKVESSMR4R_RS13175	COG0354	folic acid binding
LOKVESSMR4R_RS13180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LOKVESSMR4R_RS13190	COG1492	cobalamin metabolic process
LOKVESSMR4R_RS13205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LOKVESSMR4R_RS13235	COG2943	transferase activity, transferring hexosyl groups
LOKVESSMR4R_RS13240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LOKVESSMR4R_RS13250	COG0450	alkyl hydroperoxide reductase
LOKVESSMR4R_RS13255	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS13265	COG1162	GTPase activity
LOKVESSMR4R_RS13280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LOKVESSMR4R_RS13285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LOKVESSMR4R_RS13325	COG0714	Associated with various cellular activities
LOKVESSMR4R_RS13350	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_RS13355	COG0277	FAD linked oxidase domain protein
LOKVESSMR4R_RS13360	COG0247	lactate metabolic process
LOKVESSMR4R_RS13370	COG0071	Belongs to the small heat shock protein (HSP20) family
LOKVESSMR4R_RS13375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LOKVESSMR4R_RS13375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LOKVESSMR4R_RS13390	COG1131	(ABC) transporter
LOKVESSMR4R_RS13415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_RS13420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LOKVESSMR4R_RS13435	COG2186	Transcriptional regulator
LOKVESSMR4R_RS13440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LOKVESSMR4R_RS13450	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LOKVESSMR4R_RS13455	COG0356	it plays a direct role in the translocation of protons across the membrane
LOKVESSMR4R_RS13485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LOKVESSMR4R_RS13500	COG0228	four-way junction DNA binding
LOKVESSMR4R_RS13505	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LOKVESSMR4R_RS13510	COG0336	Belongs to the RNA methyltransferase TrmD family
LOKVESSMR4R_RS13515	COG0335	large ribosomal subunit rRNA binding
LOKVESSMR4R_RS13520	COG0254	rRNA binding
LOKVESSMR4R_RS13525	COG0840	transmembrane signaling receptor activity
LOKVESSMR4R_RS13535	COG0513	Belongs to the DEAD box helicase family
LOKVESSMR4R_RS13540	COG0489	protein tyrosine kinase activity
LOKVESSMR4R_RS13540	COG2151	metal-sulfur cluster biosynthetic enzyme
LOKVESSMR4R_RS13545	COG0697	spore germination
LOKVESSMR4R_RS13550	COG0473	3-isopropylmalate dehydrogenase activity
LOKVESSMR4R_RS13565	COG0066	3-isopropylmalate dehydratase activity
LOKVESSMR4R_RS13570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LOKVESSMR4R_RS13585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LOKVESSMR4R_RS13590	COG0830	nickel cation binding
LOKVESSMR4R_RS13595	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LOKVESSMR4R_RS13605	COG0804	urea catabolic process
LOKVESSMR4R_RS13610	COG0832	Belongs to the urease beta subunit family
LOKVESSMR4R_RS13615	COG0831	urea catabolic process
LOKVESSMR4R_RS13620	COG0829	nickel cation binding
LOKVESSMR4R_RS13635	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
LOKVESSMR4R_RS13650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LOKVESSMR4R_RS13655	COG0667	Aldo Keto reductase
LOKVESSMR4R_RS13695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LOKVESSMR4R_RS13700	COG0756	dUTP diphosphatase activity
LOKVESSMR4R_RS13705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LOKVESSMR4R_RS13730	COG0606	chelatase, subunit chli
LOKVESSMR4R_RS13745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LOKVESSMR4R_RS13755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LOKVESSMR4R_RS13760	COG0728	peptidoglycan biosynthetic process
LOKVESSMR4R_RS13770	COG0180	Tryptophanyl-tRNA synthetase
LOKVESSMR4R_RS13775	COG2514	catechol 2,3-dioxygenase activity
LOKVESSMR4R_RS13785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LOKVESSMR4R_RS13800	COG1744	ABC transporter substrate-binding protein PnrA-like
LOKVESSMR4R_RS13820	COG4603	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS13830	COG1079	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS13840	COG0730	response to heat
LOKVESSMR4R_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS13855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LOKVESSMR4R_RS13860	COG0604	alcohol dehydrogenase
LOKVESSMR4R_RS13865	COG2937	Belongs to the GPAT DAPAT family
LOKVESSMR4R_RS13870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LOKVESSMR4R_RS13870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LOKVESSMR4R_RS13885	COG0813	purine-nucleoside phosphorylase activity
LOKVESSMR4R_RS13930	COG2030	dehydratase
LOKVESSMR4R_RS13960	COG0039	L-malate dehydrogenase activity
LOKVESSMR4R_RS13965	COG0045	succinate-CoA ligase (ADP-forming) activity
LOKVESSMR4R_RS13970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LOKVESSMR4R_RS13980	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_RS14000	COG1802	Transcriptional regulator
LOKVESSMR4R_RS14035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LOKVESSMR4R_RS14045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LOKVESSMR4R_RS14065	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LOKVESSMR4R_RS14070	COG3257	ureidoglycine aminohydrolase activity
LOKVESSMR4R_RS14075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LOKVESSMR4R_RS14090	COG0741	lytic transglycosylase activity
LOKVESSMR4R_RS14095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOKVESSMR4R_RS14100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LOKVESSMR4R_RS14105	COG2897	thiosulfate sulfurtransferase activity
LOKVESSMR4R_RS14115	COG2301	Belongs to the HpcH HpaI aldolase family
LOKVESSMR4R_RS14120	COG0825	malonyl-CoA metabolic process
LOKVESSMR4R_RS14135	COG2884	Cell division ATP-binding protein ftsE
LOKVESSMR4R_RS14150	COG0019	diaminopimelate decarboxylase activity
LOKVESSMR4R_RS14160	COG0165	Argininosuccinate lyase
LOKVESSMR4R_RS14165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LOKVESSMR4R_RS14170	COG1678	Uncharacterized ACR, COG1678
LOKVESSMR4R_RS14190	COG0521	Mo-molybdopterin cofactor biosynthetic process
LOKVESSMR4R_RS14195	COG1573	uracil-dna glycosylase
LOKVESSMR4R_RS14200	COG0540	Belongs to the ATCase OTCase family
LOKVESSMR4R_RS14210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LOKVESSMR4R_RS14215	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LOKVESSMR4R_RS14235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LOKVESSMR4R_RS14240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LOKVESSMR4R_RS14245	COG2885	chlorophyll binding
LOKVESSMR4R_RS14255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LOKVESSMR4R_RS14260	COG0009	L-threonylcarbamoyladenylate synthase
LOKVESSMR4R_RS14265	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS14285	COG1522	sequence-specific DNA binding
LOKVESSMR4R_RS14310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LOKVESSMR4R_RS14320	COG1763	Mo-molybdopterin cofactor biosynthetic process
LOKVESSMR4R_RS14325	COG0303	'Molybdopterin
LOKVESSMR4R_RS14350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LOKVESSMR4R_RS14380	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LOKVESSMR4R_RS14390	COG0288	reversible hydration of carbon dioxide
LOKVESSMR4R_RS14405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LOKVESSMR4R_RS14410	COG0596	Alpha beta hydrolase
LOKVESSMR4R_RS14415	COG2423	ornithine cyclodeaminase activity
LOKVESSMR4R_RS14425	COG1671	Belongs to the UPF0178 family
LOKVESSMR4R_RS14430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LOKVESSMR4R_RS14450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LOKVESSMR4R_RS14460	COG0793	Belongs to the peptidase S41A family
LOKVESSMR4R_RS14470	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LOKVESSMR4R_RS14475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LOKVESSMR4R_RS14480	COG0799	negative regulation of ribosome biogenesis
LOKVESSMR4R_RS14485	COG1063	alcohol dehydrogenase
LOKVESSMR4R_RS14490	COG0708	Exodeoxyribonuclease III
LOKVESSMR4R_RS14505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LOKVESSMR4R_RS14510	COG3265	gluconokinase activity
LOKVESSMR4R_RS14535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKVESSMR4R_RS14540	COG4948	Mandelate Racemase Muconate Lactonizing
LOKVESSMR4R_RS14550	COG0004	ammonium transporteR
LOKVESSMR4R_RS14555	COG0347	Belongs to the P(II) protein family
LOKVESSMR4R_RS14570	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
LOKVESSMR4R_RS14575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LOKVESSMR4R_RS14595	COG2154	pterin-4-alpha-carbinolamine dehydratase
LOKVESSMR4R_RS14600	COG0668	transmembrane transport
LOKVESSMR4R_RS14605	COG0678	peroxiredoxin activity
LOKVESSMR4R_RS14615	COG0742	ribosomal rna small subunit methyltransferase
LOKVESSMR4R_RS14620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LOKVESSMR4R_RS14635	COG0285	dihydrofolate synthase activity
LOKVESSMR4R_RS14640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LOKVESSMR4R_RS14650	COG0129	dihydroxy-acid dehydratase activity
LOKVESSMR4R_RS14670	COG1902	pentaerythritol trinitrate reductase activity
LOKVESSMR4R_RS14670	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS14675	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS14680	COG3706	GGDEF domain
LOKVESSMR4R_RS14700	COG1058	Belongs to the CinA family
LOKVESSMR4R_RS14700	COG1546	Belongs to the CinA family
LOKVESSMR4R_RS14705	COG0024	Methionine aminopeptidase
LOKVESSMR4R_RS14720	COG0142	geranyltranstransferase activity
LOKVESSMR4R_RS14750	COG2200	EAL domain
LOKVESSMR4R_RS14755	COG2818	Glycosylase
LOKVESSMR4R_RS14760	COG0314	molybdopterin synthase activity
LOKVESSMR4R_RS14770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LOKVESSMR4R_RS14775	COG0322	excinuclease ABC activity
LOKVESSMR4R_RS14790	COG0842	Transport permease protein
LOKVESSMR4R_RS14795	COG1131	(ABC) transporter
LOKVESSMR4R_RS14805	COG3266	domain, Protein
LOKVESSMR4R_RS14805	COG0515	serine threonine protein kinase
LOKVESSMR4R_RS14825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LOKVESSMR4R_RS14855	COG0583	DNA-binding transcription factor activity
LOKVESSMR4R_RS14860	COG0523	cobalamin synthesis protein
LOKVESSMR4R_RS14895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LOKVESSMR4R_RS14915	COG0471	metal ion transport
LOKVESSMR4R_RS14915	COG3273	potassium ion transport
LOKVESSMR4R_RS14920	COG0589	response to stress
LOKVESSMR4R_RS14925	COG0659	secondary active sulfate transmembrane transporter activity
LOKVESSMR4R_RS14940	COG0352	thiamine-phosphate diphosphorylase activity
LOKVESSMR4R_RS14945	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LOKVESSMR4R_RS14950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_RS14960	COG1335	isochorismatase
LOKVESSMR4R_RS14970	COG1177	transmembrane transport
LOKVESSMR4R_RS14975	COG3842	ATPase activity
LOKVESSMR4R_RS15000	COG4770	biotin carboxylase activity
LOKVESSMR4R_RS15010	COG3665	Urea carboxylase-associated protein
LOKVESSMR4R_RS15060	COG0784	Response regulator, receiver
LOKVESSMR4R_RS15100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LOKVESSMR4R_RS15120	COG0706	membrane insertase activity
LOKVESSMR4R_RS15125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LOKVESSMR4R_RS15130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LOKVESSMR4R_RS15145	COG1126	abc transporter atp-binding protein
LOKVESSMR4R_RS15150	COG0765	amino acid transport
LOKVESSMR4R_RS15155	COG4597	amino acid ABC transporter
LOKVESSMR4R_RS15160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LOKVESSMR4R_RS15170	COG0546	phosphoglycolate phosphatase activity
LOKVESSMR4R_RS15175	COG0564	pseudouridine synthase activity
LOKVESSMR4R_RS15180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LOKVESSMR4R_RS15185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LOKVESSMR4R_RS15195	COG0202	RNA polymerase activity
LOKVESSMR4R_RS15200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LOKVESSMR4R_RS15205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LOKVESSMR4R_RS15210	COG0563	adenylate kinase activity
LOKVESSMR4R_RS15215	COG0201	protein transport
LOKVESSMR4R_RS15220	COG0200	Binds to the 23S rRNA
LOKVESSMR4R_RS15225	COG3842	ATPase activity
LOKVESSMR4R_RS15235	COG1175	transmembrane transport
LOKVESSMR4R_RS15250	COG0673	inositol 2-dehydrogenase activity
LOKVESSMR4R_RS15460	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS15475	COG1475	DNA binding
LOKVESSMR4R_RS15570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LOKVESSMR4R_RS15655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LOKVESSMR4R_RS15675	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LOKVESSMR4R_RS15710	COG2925	Exonuclease
LOKVESSMR4R_RS15715	COG3177	Filamentation induced by cAMP protein fic
LOKVESSMR4R_RS15720	COG4372	Transposase
LOKVESSMR4R_RS15725	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS15730	COG2963	transposase activity
LOKVESSMR4R_RS15745	COG1940	carbohydrate kinase activity
LOKVESSMR4R_RS15750	COG2998	abc-type tungstate transport system, permease component
LOKVESSMR4R_RS15755	COG3842	ATPase activity
LOKVESSMR4R_RS15760	COG1177	transmembrane transport
LOKVESSMR4R_RS15775	COG2222	sugar isomerase
LOKVESSMR4R_RS15780	COG1940	carbohydrate kinase activity
LOKVESSMR4R_RS15785	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
LOKVESSMR4R_RS15790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LOKVESSMR4R_RS15805	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS15840	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LOKVESSMR4R_RS15845	COG3842	ATPase activity
LOKVESSMR4R_RS15850	COG1176	ABC-type spermidine putrescine transport system, permease component I
LOKVESSMR4R_RS15855	COG1177	transmembrane transport
LOKVESSMR4R_RS15870	COG2962	Rard protein
LOKVESSMR4R_RS15885	COG1475	DNA binding
LOKVESSMR4R_RS15930	COG1028	Short-chain dehydrogenase reductase Sdr
LOKVESSMR4R_RS15940	COG1116	anion transmembrane transporter activity
LOKVESSMR4R_RS15960	COG0726	polysaccharide deacetylase
LOKVESSMR4R_RS16045	COG1335	isochorismatase
LOKVESSMR4R_RS16050	COG2309	aminopeptidase activity
LOKVESSMR4R_RS16055	COG0596	Alpha beta hydrolase
LOKVESSMR4R_RS16060	COG3473	Maleate cis-trans isomerase
LOKVESSMR4R_RS16090	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS16095	COG3547	Transposase (IS116 IS110 IS902 family)
LOKVESSMR4R_RS16100	COG2963	transposase activity
LOKVESSMR4R_RS16120	COG2963	transposase activity
LOKVESSMR4R_RS16135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LOKVESSMR4R_RS16150	COG2391	methyltransferase activity
LOKVESSMR4R_RS16170	COG0508	dehydrogenase complex catalyzes the overall conversion of
LOKVESSMR4R_RS16175	COG0022	dehydrogenase e1 component
LOKVESSMR4R_RS16180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LOKVESSMR4R_RS16185	COG0006	proline dipeptidase activity
LOKVESSMR4R_RS16200	COG1879	ABC-type sugar transport system periplasmic component
LOKVESSMR4R_RS16205	COG1172	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS16210	COG4211	Belongs to the binding-protein-dependent transport system permease family
LOKVESSMR4R_RS16215	COG1129	ABC transporter
LOKVESSMR4R_RS16255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LOKVESSMR4R_RS16260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LOKVESSMR4R_RS16270	COG0284	orotidine-5'-phosphate decarboxylase activity
LOKVESSMR4R_RS16285	COG0330	HflC and HflK could
LOKVESSMR4R_RS16295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LOKVESSMR4R_RS16310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LOKVESSMR4R_RS16325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LOKVESSMR4R_RS16360	COG3383	formate dehydrogenase (NAD+) activity
LOKVESSMR4R_RS16380	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LOKVESSMR4R_RS16390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LOKVESSMR4R_RS16410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LOKVESSMR4R_RS16415	COG1215	transferase activity, transferring glycosyl groups
LOKVESSMR4R_RS16420	COG1335	isochorismatase
LOKVESSMR4R_RS16425	COG0443	Heat shock 70 kDa protein
LOKVESSMR4R_RS16430	COG1054	Belongs to the UPF0176 family
LOKVESSMR4R_RS16455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LOKVESSMR4R_RS16465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LOKVESSMR4R_RS16470	COG0268	Binds directly to 16S ribosomal RNA
LOKVESSMR4R_RS16480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LOKVESSMR4R_RS16485	COG2226	methyltransferase
LOKVESSMR4R_RS16495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LOKVESSMR4R_RS16520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LOKVESSMR4R_RS16525	COG2211	Major facilitator Superfamily
LOKVESSMR4R_RS16530	COG0644	oxidoreductase
LOKVESSMR4R_RS16535	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
LOKVESSMR4R_RS16540	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LOKVESSMR4R_RS16560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LOKVESSMR4R_RS16565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_RS16570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LOKVESSMR4R_RS16585	COG0322	excinuclease ABC activity
LOKVESSMR4R_RS16595	COG1309	transcriptional regulator
LOKVESSMR4R_RS16605	COG0167	dihydroorotate dehydrogenase activity
LOKVESSMR4R_RS16605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LOKVESSMR4R_RS16610	COG0493	'glutamate synthase
LOKVESSMR4R_RS16620	COG0129	dihydroxy-acid dehydratase activity
LOKVESSMR4R_RS16625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LOKVESSMR4R_RS16640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LOKVESSMR4R_RS16655	COG2176	DNA-directed DNA polymerase activity
LOKVESSMR4R_RS16655	COG5002	protein histidine kinase activity
LOKVESSMR4R_RS16675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LOKVESSMR4R_RS16680	COG0142	geranyltranstransferase activity
LOKVESSMR4R_RS16685	COG1722	exodeoxyribonuclease VII activity
LOKVESSMR4R_RS16690	COG0123	including yeast histone deacetylase and acetoin utilization protein
LOKVESSMR4R_RS16695	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS16700	COG1846	Transcriptional regulator
LOKVESSMR4R_RS16705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LOKVESSMR4R_RS16725	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LOKVESSMR4R_RS16735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LOKVESSMR4R_RS16755	COG1968	undecaprenyl-diphosphatase activity
LOKVESSMR4R_RS16860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LOKVESSMR4R_RS16875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LOKVESSMR4R_RS16880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LOKVESSMR4R_RS16895	COG0446	pyridine nucleotide-disulphide oxidoreductase
LOKVESSMR4R_RS16910	COG2610	gluconate transmembrane transporter activity
LOKVESSMR4R_RS16925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LOKVESSMR4R_RS16940	COG0582	viral genome integration into host DNA
LOKVESSMR4R_RS16955	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS17090	COG1360	Flagellar Motor Protein
LOKVESSMR4R_RS17100	COG1484	DNA-dependent DNA replication
LOKVESSMR4R_RS17105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LOKVESSMR4R_RS17135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LOKVESSMR4R_RS17145	COG1987	bacterial-type flagellum assembly
LOKVESSMR4R_RS17205	COG1677	Flagellar hook-basal body complex protein FliE
LOKVESSMR4R_RS17230	COG0455	bacterial-type flagellum organization
LOKVESSMR4R_RS17240	COG4786	Flagellar basal body rod
LOKVESSMR4R_RS17270	COG4786	Flagellar basal body rod
LOKVESSMR4R_RS17280	COG1749	Flagellar hook protein flgE
LOKVESSMR4R_RS17285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LOKVESSMR4R_RS17290	COG1558	bacterial-type flagellum-dependent cell motility
LOKVESSMR4R_RS17310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LOKVESSMR4R_RS17335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LOKVESSMR4R_RS17340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LOKVESSMR4R_RS17355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LOKVESSMR4R_RS17360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LOKVESSMR4R_RS17395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LOKVESSMR4R_RS17400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LOKVESSMR4R_RS17430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LOKVESSMR4R_RS17435	COG1218	3'(2'),5'-bisphosphate nucleotidase
LOKVESSMR4R_RS17445	COG0443	Heat shock 70 kDa protein
LOKVESSMR4R_RS17450	COG0484	heat shock protein binding
LOKVESSMR4R_RS17455	COG2003	Belongs to the UPF0758 family
LOKVESSMR4R_RS17495	COG4372	Transposase
LOKVESSMR4R_RS17500	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS17505	COG2963	transposase activity
LOKVESSMR4R_RS17515	COG0582	viral genome integration into host DNA
LOKVESSMR4R_RS17525	COG0653	protein targeting
LOKVESSMR4R_RS17530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LOKVESSMR4R_RS17535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LOKVESSMR4R_RS17540	COG0494	nUDIX hydrolase
LOKVESSMR4R_RS17545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LOKVESSMR4R_RS17560	COG0779	Required for maturation of 30S ribosomal subunits
LOKVESSMR4R_RS17565	COG0747	negative chemotaxis
LOKVESSMR4R_RS17585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS17590	COG0601	transmembrane transport
LOKVESSMR4R_RS17600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LOKVESSMR4R_RS17610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LOKVESSMR4R_RS17620	COG1040	competence protein
LOKVESSMR4R_RS17625	COG2226	methyltransferase
LOKVESSMR4R_RS17645	COG3034	peptidoglycan biosynthetic process
LOKVESSMR4R_RS17655	COG1132	(ABC) transporter
LOKVESSMR4R_RS17660	COG1132	(ABC) transporter
LOKVESSMR4R_RS17665	COG0617	tRNA 3'-terminal CCA addition
LOKVESSMR4R_RS17670	COG0494	nUDIX hydrolase
LOKVESSMR4R_RS17685	COG0137	argininosuccinate synthase activity
LOKVESSMR4R_RS17705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LOKVESSMR4R_RS17710	COG0281	malic enzyme
LOKVESSMR4R_RS17710	COG0280	phosphate acetyltransferase
LOKVESSMR4R_RS17715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LOKVESSMR4R_RS17720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LOKVESSMR4R_RS17730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LOKVESSMR4R_RS17735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LOKVESSMR4R_RS17740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LOKVESSMR4R_RS17760	COG0445	tRNA wobble uridine modification
LOKVESSMR4R_RS17765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LOKVESSMR4R_RS17770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LOKVESSMR4R_RS17775	COG1981	membrane
LOKVESSMR4R_RS17780	COG0424	maF-like protein
LOKVESSMR4R_RS17785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LOKVESSMR4R_RS17790	COG0237	dephospho-CoA kinase activity
LOKVESSMR4R_RS17795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LOKVESSMR4R_RS17800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LOKVESSMR4R_RS17805	COG3030	protein affecting phage T7 exclusion by the F plasmid
LOKVESSMR4R_RS17820	COG2840	Smr protein MutS2
LOKVESSMR4R_RS17830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LOKVESSMR4R_RS17840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LOKVESSMR4R_RS17855	COG1074	ATP-dependent DNA helicase activity
LOKVESSMR4R_RS17865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LOKVESSMR4R_RS17870	COG3178	'Phosphotransferase
LOKVESSMR4R_RS17890	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LOKVESSMR4R_RS17895	COG2847	Copper chaperone PCu(A)C
LOKVESSMR4R_RS17915	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_RS17920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_RS17925	COG1429	ligase activity, forming nitrogen-metal bonds
LOKVESSMR4R_RS17930	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LOKVESSMR4R_RS17965	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LOKVESSMR4R_RS17975	COG0156	8-amino-7-oxononanoate synthase activity
LOKVESSMR4R_RS17990	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LOKVESSMR4R_RS17995	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
LOKVESSMR4R_RS18005	COG1233	COG1233 Phytoene dehydrogenase and related
LOKVESSMR4R_RS18010	COG1562	ergosterol biosynthetic process
LOKVESSMR4R_RS18015	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
LOKVESSMR4R_RS18020	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LOKVESSMR4R_RS18025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LOKVESSMR4R_RS18040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LOKVESSMR4R_RS18045	COG4143	(ABC) transporter
LOKVESSMR4R_RS18050	COG1178	ABC-type Fe3 transport system permease component
LOKVESSMR4R_RS18055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LOKVESSMR4R_RS18090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LOKVESSMR4R_RS18095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LOKVESSMR4R_RS18110	COG0366	Alpha amylase catalytic
LOKVESSMR4R_RS18115	COG0366	Alpha amylase catalytic
LOKVESSMR4R_RS18120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LOKVESSMR4R_RS18130	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LOKVESSMR4R_RS18135	COG1640	4-alpha-glucanotransferase
LOKVESSMR4R_RS18145	COG4372	Transposase
LOKVESSMR4R_RS18150	COG3436	PFAM IS66 Orf2 family protein
LOKVESSMR4R_RS18155	COG2963	transposase activity
LOKVESSMR4R_RS18175	COG3191	aminopeptidase activity
LOKVESSMR4R_RS18195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LOKVESSMR4R_RS18205	COG0747	negative chemotaxis
LOKVESSMR4R_RS18210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LOKVESSMR4R_RS18240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LOKVESSMR4R_RS18245	COG4134	Bacterial extracellular solute-binding protein
LOKVESSMR4R_RS18250	COG4135	transport system, permease component
LOKVESSMR4R_RS18255	COG4136	ATPase activity
LOKVESSMR4R_RS18265	COG5621	secreted hydrolase
LOKVESSMR4R_RS18270	COG1233	COG1233 Phytoene dehydrogenase and related
LOKVESSMR4R_RS18275	COG0142	geranyltranstransferase activity
LOKVESSMR4R_RS18280	COG0500	methyltransferase
LOKVESSMR4R_RS18285	COG1063	alcohol dehydrogenase
LOKVESSMR4R_RS18290	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
LOKVESSMR4R_RS18295	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_RS18300	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
LOKVESSMR4R_RS18335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LOKVESSMR4R_RS18340	COG1132	(ABC) transporter
LOKVESSMR4R_RS18450	COG0616	signal peptide processing
LOKVESSMR4R_RS18480	COG3306	glycosyltransferase involved in LPS biosynthesis
LOKVESSMR4R_RS18545	COG3750	Belongs to the UPF0335 family
LOKVESSMR4R_RS18560	COG1910	domain protein
LOKVESSMR4R_RS18590	COG1609	Transcriptional regulator
LOKVESSMR4R_RS18605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LOKVESSMR4R_RS18625	COG1194	a g-specific adenine glycosylase
LOKVESSMR4R_RS18635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LOKVESSMR4R_RS18640	COG1663	tetraacyldisaccharide 4'-kinase activity
LOKVESSMR4R_RS18645	COG1519	Transferase
LOKVESSMR4R_RS18660	COG0312	modulator of DNA gyrase
LOKVESSMR4R_RS18670	COG4221	oxidoreductase activity
LOKVESSMR4R_RS18680	COG2081	HI0933 family
LOKVESSMR4R_RS18685	COG0625	glutathione transferase activity
LOKVESSMR4R_RS18700	COG0495	leucyl-tRNA aminoacylation
LOKVESSMR4R_RS18710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LOKVESSMR4R_RS18715	COG0564	pseudouridine synthase activity
LOKVESSMR4R_RS18725	COG0346	lactoylglutathione lyase activity
LOKVESSMR4R_RS18735	COG0450	alkyl hydroperoxide reductase
LOKVESSMR4R_RS18745	COG1185	polyribonucleotide nucleotidyltransferase activity
LOKVESSMR4R_RS18750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LOKVESSMR4R_RS18760	COG0596	Alpha beta hydrolase
LOKVESSMR4R_RS18770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LOKVESSMR4R_RS18775	COG4067	protein conserved in archaea
LOKVESSMR4R_RS18775	COG0189	ligase activity
LOKVESSMR4R_RS18780	COG0189	ligase activity
LOKVESSMR4R_RS18790	COG0514	ATP-dependent DNA helicase (RecQ)
LOKVESSMR4R_RS18825	COG2211	Major facilitator Superfamily
LOKVESSMR4R_RS18840	COG1595	DNA-templated transcription, initiation
LOKVESSMR4R_RS18845	COG3806	Anti-sigma factor
LOKVESSMR4R_RS18855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LOKVESSMR4R_RS18860	COG0612	Peptidase, M16
LOKVESSMR4R_RS18865	COG0612	Peptidase, M16
LOKVESSMR4R_RS18875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LOKVESSMR4R_RS18880	COG0138	bifunctional purine biosynthesis protein purh
LOKVESSMR4R_RS18890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LOKVESSMR4R_RS18910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LOKVESSMR4R_RS18915	COG0628	permease
LOKVESSMR4R_RS18940	COG1376	ErfK ybiS ycfS ynhG family protein
LOKVESSMR4R_RS18955	COG0765	amino acid transport
LOKVESSMR4R_RS18965	COG2133	pyrroloquinoline quinone binding
LOKVESSMR4R_RS18970	COG0745	RESPONSE REGULATOR receiver
LOKVESSMR4R_RS18995	COG2311	Membrane
LOKVESSMR4R_RS19000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LOKVESSMR4R_RS19005	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
LOKVESSMR4R_RS19005	COG0662	Cupin 2, conserved barrel domain protein
LOKVESSMR4R_RS19020	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS19050	COG1192	Involved in chromosome partitioning
LOKVESSMR4R_RS19080	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LOKVESSMR4R_RS19085	COG3626	phosphonate metabolism
LOKVESSMR4R_RS19090	COG3627	carbon phosphorus lyase activity
LOKVESSMR4R_RS19095	COG4107	phosphonate C-P lyase system protein PhnK
LOKVESSMR4R_RS19100	COG4778	phosphonate C-P lyase system protein PhnL
LOKVESSMR4R_RS19230	COG4644	lycopene metabolic process
LOKVESSMR4R_RS19295	COG3609	addiction module antidote protein, CC2985 family
LOKVESSMR4R_RS19325	COG1475	DNA binding
LOKVESSMR4R_RS19340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LOKVESSMR4R_RS19345	COG1454	alcohol dehydrogenase
LOKVESSMR4R_RS19350	COG1960	acyl-CoA dehydrogenase activity
LOKVESSMR4R_RS19365	COG1024	Enoyl-CoA hydratase
LOKVESSMR4R_RS19365	COG1250	3-hydroxyacyl-CoA dehydrogenase
LOKVESSMR4R_RS19405	COG1476	TRANSCRIPTIONal
LOKVESSMR4R_RS19420	COG4644	lycopene metabolic process
LOKVESSMR4R_RS19430	COG0739	heme binding
LOKVESSMR4R_RS19430	COG0741	lytic transglycosylase activity
LOKVESSMR4R_RS19430	COG1196	nuclear chromosome segregation
LOKVESSMR4R_RS19445	COG3451	type IV secretory pathway VirB4
LOKVESSMR4R_RS19460	COG0741	lytic transglycosylase activity
LOKVESSMR4R_RS19460	COG1196	nuclear chromosome segregation
LOKVESSMR4R_RS19460	COG0739	heme binding
LOKVESSMR4R_RS19480	COG3736	Type IV secretory pathway, component VirB8
LOKVESSMR4R_RS19485	COG3504	Conjugal transfer protein
LOKVESSMR4R_RS19495	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LOKVESSMR4R_RS19505	COG3505	Type IV secretory pathway VirD4
LOKVESSMR4R_RS19540	COG0556	nucleotide-excision repair
LOKVESSMR4R_RS19570	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS19575	COG0582	viral genome integration into host DNA
LOKVESSMR4R_RS19580	COG4974	Belongs to the 'phage' integrase family
LOKVESSMR4R_RS19605	COG3077	Addiction module antitoxin, RelB DinJ family
LOKVESSMR4R_RS19620	COG1475	DNA binding
LOKVESSMR4R_RS19665	COG4717	serine-type aminopeptidase activity
LOKVESSMR4R_RS19670	COG0420	3'-5' exonuclease activity
LOKVESSMR4R_RS19735	COG1414	Transcriptional regulator
LOKVESSMR4R_RS19740	COG1475	DNA binding
LOKVESSMR4R_RS19745	COG1192	Involved in chromosome partitioning
LOKVESSMR4R_RS19800	COG3616	Alanine racemase, N-terminal domain
LOKVESSMR4R_RS19805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LOKVESSMR4R_RS19810	COG0251	oxidation-reduction process
LOKVESSMR4R_RS19815	COG0579	oxidoreductase
LOKVESSMR4R_RS19820	COG0251	oxidation-reduction process
LOKVESSMR4R_RS19825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LOKVESSMR4R_RS19830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LOKVESSMR4R_RS19830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LOKVESSMR4R_RS19865	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LOKVESSMR4R_RS19895	COG1192	Involved in chromosome partitioning
LOKVESSMR4R_RS19915	COG3505	Type IV secretory pathway VirD4
LOKVESSMR4R_RS19920	COG4644	lycopene metabolic process
LOKVESSMR4R_RS19945	COG4227	nucleotidyltransferase activity