locus-tag	class	description
AN401_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN401_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN401_RS00025	COG0129	dihydroxy-acid dehydratase activity
AN401_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
AN401_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
AN401_RS00040	COG3977	Valine--pyruvate aminotransferase
AN401_RS00050	COG0751	glycine-tRNA ligase activity
AN401_RS00055	COG0752	glycyl-tRNA synthetase alpha subunit
AN401_RS00060	COG2818	Glycosylase
AN401_RS00065	COG2885	chlorophyll binding
AN401_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
AN401_RS00080	COG0183	Belongs to the thiolase family
AN401_RS00085	COG1024	Enoyl-CoA hydratase
AN401_RS00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN401_RS00090	COG1739	Uncharacterized protein family UPF0029
AN401_RS00095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN401_RS00100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AN401_RS00130	COG4989	oxidoreductase activity
AN401_RS00135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AN401_RS00135	COG1042	CoA-binding domain protein
AN401_RS00135	COG0045	succinate-CoA ligase (ADP-forming) activity
AN401_RS00140	COG2202	Pas domain
AN401_RS00140	COG2199	diguanylate cyclase activity
AN401_RS00140	COG2200	EAL domain
AN401_RS00155	COG3135	benzoate transporter
AN401_RS00160	COG2814	Major facilitator Superfamily
AN401_RS00185	COG3485	protocatechuate 3,4-dioxygenase
AN401_RS00195	COG4948	Mandelate Racemase Muconate Lactonizing
AN401_RS00205	COG1414	Transcriptional regulator
AN401_RS00210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AN401_RS00215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AN401_RS00220	COG0183	Belongs to the thiolase family
AN401_RS00225	COG2267	carboxylic ester hydrolase activity
AN401_RS00230	COG0840	transmembrane signaling receptor activity
AN401_RS00240	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AN401_RS00250	COG1575	Belongs to the MenA family. Type 1 subfamily
AN401_RS00255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AN401_RS00265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN401_RS00275	COG2022	thiamine diphosphate biosynthetic process
AN401_RS00280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN401_RS00290	COG1984	allophanate hydrolase subunit 2
AN401_RS00295	COG1984	allophanate hydrolase subunit 2
AN401_RS00300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AN401_RS00305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AN401_RS00320	COG0583	DNA-binding transcription factor activity
AN401_RS00325	COG2188	Transcriptional regulator
AN401_RS00330	COG1486	melibiose metabolic process
AN401_RS00340	COG1253	flavin adenine dinucleotide binding
AN401_RS00355	COG0601	transmembrane transport
AN401_RS00360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_RS00365	COG4172	Belongs to the ABC transporter superfamily
AN401_RS00385	COG1288	antiporter activity
AN401_RS00390	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AN401_RS00400	COG2084	Dehydrogenase
AN401_RS00405	COG3622	Belongs to the hyi family
AN401_RS00410	COG3960	tartronate-semialdehyde synthase activity
AN401_RS00420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN401_RS00430	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AN401_RS00470	COG1047	Peptidyl-prolyl cis-trans
AN401_RS00475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_RS00480	COG0339	signal peptide processing
AN401_RS00490	COG0742	ribosomal rna small subunit methyltransferase
AN401_RS00505	COG0523	cobalamin synthesis protein
AN401_RS00510	COG0604	alcohol dehydrogenase
AN401_RS00515	COG0697	spore germination
AN401_RS00525	COG0589	response to stress
AN401_RS00535	COG2081	HI0933 family
AN401_RS00540	COG2862	Uncharacterized protein family, UPF0114
AN401_RS00550	COG1253	flavin adenine dinucleotide binding
AN401_RS00555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN401_RS00560	COG0800	Aldolase
AN401_RS00580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_RS00585	COG1609	Transcriptional regulator
AN401_RS00590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS00605	COG0656	L-ascorbic acid biosynthetic process
AN401_RS00615	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AN401_RS00620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AN401_RS00635	COG0561	phosphatase activity
AN401_RS00640	COG2267	carboxylic ester hydrolase activity
AN401_RS00645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN401_RS00650	COG1758	RNA polymerase activity
AN401_RS00655	COG0194	GDP metabolic process
AN401_RS00670	COG1561	YicC-like family, N-terminal region
AN401_RS00685	COG0668	transmembrane transport
AN401_RS00690	COG1309	transcriptional regulator
AN401_RS00695	COG0756	dUTP diphosphatase activity
AN401_RS00700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AN401_RS00705	COG2003	Belongs to the UPF0758 family
AN401_RS00710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN401_RS00715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN401_RS00720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AN401_RS00725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AN401_RS00730	COG0859	PFAM glycosyl transferase family 9
AN401_RS00735	COG0463	Glycosyl transferase, family 2
AN401_RS00740	COG0859	PFAM glycosyl transferase family 9
AN401_RS00745	COG3642	lipopolysaccharide core region biosynthetic process
AN401_RS00750	COG1519	Transferase
AN401_RS00755	COG0859	PFAM glycosyl transferase family 9
AN401_RS00790	COG0726	polysaccharide deacetylase
AN401_RS00795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN401_RS00805	COG0156	8-amino-7-oxononanoate synthase activity
AN401_RS00810	COG1063	alcohol dehydrogenase
AN401_RS00820	COG0683	leucine binding
AN401_RS00845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_RS00860	COG3161	chorismate lyase activity
AN401_RS00865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AN401_RS00870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN401_RS00880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AN401_RS00880	COG1565	acr, cog1565
AN401_RS00885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AN401_RS00915	COG1612	heme a metabolic process
AN401_RS00920	COG0109	protoheme IX farnesyltransferase activity
AN401_RS00930	COG0534	Mate efflux family protein
AN401_RS00935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN401_RS00955	COG3074	FtsZ-dependent cytokinesis
AN401_RS00960	COG3610	response to peptide
AN401_RS00965	COG2966	Psort location CytoplasmicMembrane, score
AN401_RS00970	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_RS00975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AN401_RS00980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AN401_RS00985	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN401_RS00990	COG0018	arginyl-trna synthetase
AN401_RS01000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN401_RS01005	COG0254	rRNA binding
AN401_RS01015	COG0281	malic enzyme
AN401_RS01020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN401_RS01025	COG4206	TonB-dependent receptor
AN401_RS01035	COG0724	RNA recognition motif
AN401_RS01065	COG0671	phosphoesterase, PA-phosphatase related
AN401_RS01070	COG0583	DNA-binding transcription factor activity
AN401_RS01080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN401_RS01085	COG3047	cAMP biosynthetic process
AN401_RS01090	COG0579	oxidoreductase
AN401_RS01100	COG1802	Transcriptional regulator
AN401_RS01105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN401_RS01125	COG1279	arginine transmembrane transporter activity
AN401_RS01130	COG2873	o-acetylhomoserine
AN401_RS01135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN401_RS01140	COG2873	o-acetylhomoserine
AN401_RS01160	COG1522	sequence-specific DNA binding
AN401_RS01165	COG2502	aspartate--ammonia ligase
AN401_RS01170	COG0517	IMP dehydrogenase activity
AN401_RS01170	COG0617	tRNA 3'-terminal CCA addition
AN401_RS01170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AN401_RS01175	COG2205	protein histidine kinase activity
AN401_RS01185	COG2204	response regulator
AN401_RS01205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AN401_RS01230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AN401_RS01265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN401_RS01285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AN401_RS01295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AN401_RS01305	COG0085	RNA polymerase activity
AN401_RS01310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AN401_RS01315	COG1024	Enoyl-CoA hydratase
AN401_RS01320	COG2847	Copper chaperone PCu(A)C
AN401_RS01325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AN401_RS01330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN401_RS01335	COG0175	sulfate reduction
AN401_RS01340	COG0517	IMP dehydrogenase activity
AN401_RS01345	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN401_RS01345	COG1648	precorrin-2 dehydrogenase activity
AN401_RS01355	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AN401_RS01360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN401_RS01365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN401_RS01370	COG0163	prenyltransferase activity
AN401_RS01380	COG1131	(ABC) transporter
AN401_RS01385	COG0842	Transport permease protein
AN401_RS01390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AN401_RS01395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AN401_RS01400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AN401_RS01410	COG0617	tRNA 3'-terminal CCA addition
AN401_RS01415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN401_RS01420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN401_RS01425	COG1489	DNA binding
AN401_RS01435	COG1643	Atp-dependent helicase
AN401_RS01440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN401_RS01450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AN401_RS01460	COG0316	Belongs to the HesB IscA family
AN401_RS01480	COG0739	heme binding
AN401_RS01485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN401_RS01495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_RS01505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AN401_RS01510	COG0493	'glutamate synthase
AN401_RS01515	COG0067	glutamate synthase
AN401_RS01515	COG0069	glutamate synthase activity
AN401_RS01515	COG0070	glutamate synthase
AN401_RS01520	COG2198	Histidine kinase
AN401_RS01520	COG0784	Response regulator, receiver
AN401_RS01520	COG5002	protein histidine kinase activity
AN401_RS01540	COG1464	Belongs to the NlpA lipoprotein family
AN401_RS01545	COG2011	ABC-type metal ion transport system permease component
AN401_RS01555	COG4174	ABC transporter (Permease)
AN401_RS01560	COG4239	(ABC) transporter, permease
AN401_RS01565	COG0747	negative chemotaxis
AN401_RS01570	COG0444	Belongs to the ABC transporter superfamily
AN401_RS01575	COG4608	Belongs to the ABC transporter superfamily
AN401_RS01580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AN401_RS01610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AN401_RS01620	COG1178	ABC-type Fe3 transport system permease component
AN401_RS01640	COG0066	3-isopropylmalate dehydratase activity
AN401_RS01645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AN401_RS01650	COG0473	3-isopropylmalate dehydrogenase activity
AN401_RS01655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN401_RS01660	COG0028	Belongs to the TPP enzyme family
AN401_RS01670	COG2964	Protein conserved in bacteria
AN401_RS01675	COG0251	oxidation-reduction process
AN401_RS01690	COG2168	tRNA wobble position uridine thiolation
AN401_RS01695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AN401_RS01700	COG0049	tRNA binding
AN401_RS01705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AN401_RS01710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AN401_RS01730	COG2193	ferroxidase activity
AN401_RS01735	COG1803	Methylglyoxal synthase
AN401_RS01750	COG1309	transcriptional regulator
AN401_RS01755	COG2814	Major facilitator Superfamily
AN401_RS01765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AN401_RS01775	COG0402	S-adenosylhomocysteine deaminase activity
AN401_RS01780	COG2186	Transcriptional regulator
AN401_RS01795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_RS01815	COG1234	tRNA 3'-trailer cleavage
AN401_RS01825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS01825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS01830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS01830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS01835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS01875	COG2252	PERMEase
AN401_RS01895	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AN401_RS01900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AN401_RS01925	COG0840	transmembrane signaling receptor activity
AN401_RS01950	COG0583	DNA-binding transcription factor activity
AN401_RS01955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AN401_RS01965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AN401_RS01985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AN401_RS01990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AN401_RS01995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AN401_RS02000	COG1968	undecaprenyl-diphosphatase activity
AN401_RS02005	COG0617	tRNA 3'-terminal CCA addition
AN401_RS02030	COG4991	sh3 domain protein
AN401_RS02035	COG0306	phosphate transporter
AN401_RS02040	COG1392	Phosphate transport regulator
AN401_RS02045	COG3025	triphosphatase activity
AN401_RS02060	COG3789	protein conserved in bacteria
AN401_RS02070	COG1560	Kdo2-lipid A biosynthetic process
AN401_RS02075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AN401_RS02075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AN401_RS02085	COG2146	nitrite reductase [NAD(P)H] activity
AN401_RS02085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN401_RS02100	COG0243	molybdopterin cofactor binding
AN401_RS02105	COG1538	Outer membrane efflux protein
AN401_RS02110	COG0494	nUDIX hydrolase
AN401_RS02120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AN401_RS02125	COG3707	response regulator
AN401_RS02130	COG1116	anion transmembrane transporter activity
AN401_RS02135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN401_RS02140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN401_RS02145	COG3150	esterase
AN401_RS02170	COG4948	Mandelate Racemase Muconate Lactonizing
AN401_RS02180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS02180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS02190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS02195	COG2186	Transcriptional regulator
AN401_RS02200	COG0494	nUDIX hydrolase
AN401_RS02205	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AN401_RS02210	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AN401_RS02215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN401_RS02235	COG0762	integral membrane protein
AN401_RS02240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AN401_RS02245	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AN401_RS02260	COG3022	response to hydroperoxide
AN401_RS02265	COG0513	Belongs to the DEAD box helicase family
AN401_RS02270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AN401_RS02285	COG0716	FMN binding
AN401_RS02290	COG4974	Belongs to the 'phage' integrase family
AN401_RS02315	COG0697	spore germination
AN401_RS02325	COG2423	ornithine cyclodeaminase activity
AN401_RS02330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN401_RS02335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AN401_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS02345	COG1522	sequence-specific DNA binding
AN401_RS02350	COG3608	succinylglutamate desuccinylase aspartoacylase
AN401_RS02355	COG0006	proline dipeptidase activity
AN401_RS02360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_RS02365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS02370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS02375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS02380	COG0006	proline dipeptidase activity
AN401_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS02395	COG1473	amidohydrolase
AN401_RS02400	COG1301	dicarboxylic acid transport
AN401_RS02420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AN401_RS02430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AN401_RS02435	COG1595	DNA-templated transcription, initiation
AN401_RS02450	COG3086	response to oxidative stress
AN401_RS02455	COG0481	GTPase activity
AN401_RS02460	COG0681	Belongs to the peptidase S26 family
AN401_RS02465	COG0571	ribonuclease III activity
AN401_RS02480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AN401_RS02490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN401_RS02495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN401_RS02500	COG3956	TIGRFAM MazG family protein
AN401_RS02505	COG1263	PTS System
AN401_RS02505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_RS02510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AN401_RS02515	COG1959	2 iron, 2 sulfur cluster binding
AN401_RS02520	COG4536	flavin adenine dinucleotide binding
AN401_RS02525	COG4137	Cytochrome C assembly protein
AN401_RS02530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AN401_RS02535	COG0228	four-way junction DNA binding
AN401_RS02540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN401_RS02545	COG0336	Belongs to the RNA methyltransferase TrmD family
AN401_RS02550	COG0335	large ribosomal subunit rRNA binding
AN401_RS02555	COG2814	Major facilitator Superfamily
AN401_RS02560	COG3066	DNA modification
AN401_RS02565	COG1051	belongs to the nudix hydrolase family
AN401_RS02575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AN401_RS02580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AN401_RS02585	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN401_RS02595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN401_RS02635	COG4695	Portal protein
AN401_RS02645	COG5654	RES domain protein
AN401_RS02745	COG5433	transposase activity
AN401_RS02755	COG2856	Zn peptidase
AN401_RS02760	COG4974	Belongs to the 'phage' integrase family
AN401_RS02765	COG0583	DNA-binding transcription factor activity
AN401_RS02770	COG0640	Transcriptional regulator
AN401_RS02775	COG0268	Binds directly to 16S ribosomal RNA
AN401_RS02780	COG0728	peptidoglycan biosynthetic process
AN401_RS02785	COG0196	riboflavin kinase activity
AN401_RS02790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN401_RS02795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AN401_RS02800	COG1047	Peptidyl-prolyl cis-trans
AN401_RS02805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AN401_RS02810	COG3706	GGDEF domain
AN401_RS02830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN401_RS02830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_RS02835	COG0347	Belongs to the P(II) protein family
AN401_RS02845	COG0557	exoribonuclease II activity
AN401_RS02855	COG2153	protein acetylation
AN401_RS02865	COG0360	Binds together with S18 to 16S ribosomal RNA
AN401_RS02870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AN401_RS02875	COG0359	binds to the 23S rRNA
AN401_RS02890	COG0612	Peptidase, M16
AN401_RS02895	COG2918	glutathione biosynthetic process
AN401_RS02900	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_RS02905	COG0564	pseudouridine synthase activity
AN401_RS02910	COG1496	oxidoreductase activity
AN401_RS02915	COG0542	response to heat
AN401_RS02950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS02960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS02960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS02970	COG1802	Transcriptional regulator
AN401_RS02980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AN401_RS02985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS03000	COG0154	amidase activity
AN401_RS03020	COG0514	ATP-dependent DNA helicase (RecQ)
AN401_RS03025	COG0625	glutathione transferase activity
AN401_RS03030	COG2259	Doxx family
AN401_RS03035	COG1741	Belongs to the pirin family
AN401_RS03040	COG1414	Transcriptional regulator
AN401_RS03055	COG2267	carboxylic ester hydrolase activity
AN401_RS03060	COG3971	2-oxopent-4-enoate hydratase activity
AN401_RS03065	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AN401_RS03070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN401_RS03100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AN401_RS03105	COG0540	Belongs to the ATCase OTCase family
AN401_RS03120	COG0456	acetyltransferase
AN401_RS03125	COG0739	heme binding
AN401_RS03140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN401_RS03145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AN401_RS03160	COG0583	DNA-binding transcription factor activity
AN401_RS03165	COG0840	transmembrane signaling receptor activity
AN401_RS03165	COG3290	protein histidine kinase activity
AN401_RS03170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AN401_RS03175	COG1687	branched-chain amino acid
AN401_RS03180	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AN401_RS03185	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AN401_RS03185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AN401_RS03190	COG3639	organic phosphonate transmembrane transporter activity
AN401_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS03205	COG0534	Mate efflux family protein
AN401_RS03215	COG1175	transmembrane transport
AN401_RS03225	COG1621	beta-fructofuranosidase activity
AN401_RS03260	COG0084	hydrolase, TatD family'
AN401_RS03265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AN401_RS03295	COG0560	Phosphoserine phosphatase
AN401_RS03305	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AN401_RS03315	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AN401_RS03320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AN401_RS03325	COG0739	heme binding
AN401_RS03330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AN401_RS03335	COG1121	(ABC) transporter
AN401_RS03340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN401_RS03345	COG1573	uracil-dna glycosylase
AN401_RS03350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_RS03355	COG3068	Protein conserved in bacteria
AN401_RS03360	COG1846	Transcriptional regulator
AN401_RS03375	COG3314	Sporulation integral membrane protein YlbJ
AN401_RS03380	COG1228	amidohydrolase
AN401_RS03385	COG0010	Belongs to the arginase family
AN401_RS03395	COG2986	histidine ammonia-lyase
AN401_RS03405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AN401_RS03420	COG1765	OsmC-like protein
AN401_RS03430	COG3954	Phosphoribulokinase
AN401_RS03435	COG3089	Belongs to the UPF0270 family
AN401_RS03440	COG0429	hydrolase of the alpha beta-hydrolase fold
AN401_RS03455	COG0583	DNA-binding transcription factor activity
AN401_RS03460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AN401_RS03470	COG0488	(ABC) transporter
AN401_RS03485	COG1047	Peptidyl-prolyl cis-trans
AN401_RS03500	COG0545	Peptidyl-prolyl cis-trans isomerase
AN401_RS03520	COG0534	Mate efflux family protein
AN401_RS03525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AN401_RS03530	COG0459	protein refolding
AN401_RS03550	COG1509	lysine 2,3-aminomutase activity
AN401_RS03555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN401_RS03560	COG0516	GMP reductase activity
AN401_RS03575	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AN401_RS03585	COG0583	DNA-binding transcription factor activity
AN401_RS03590	COG0471	metal ion transport
AN401_RS03595	COG1511	domain protein
AN401_RS03595	COG3264	Mechanosensitive ion channel
AN401_RS03600	COG0688	phosphatidylethanolamine metabolic process
AN401_RS03605	COG1162	GTPase activity
AN401_RS03610	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN401_RS03640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AN401_RS03640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AN401_RS03645	COG0802	atpase or kinase
AN401_RS03655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AN401_RS03665	COG1923	regulation of RNA biosynthetic process
AN401_RS03670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN401_RS03675	COG0330	HflC and HflK could
AN401_RS03680	COG0330	HflC and HflK could
AN401_RS03685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN401_RS03690	COG0142	geranyltranstransferase activity
AN401_RS03695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AN401_RS03700	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AN401_RS03705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AN401_RS03715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN401_RS03720	COG2967	ApaG domain
AN401_RS03725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN401_RS03730	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AN401_RS03735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN401_RS03740	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AN401_RS03745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AN401_RS03750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN401_RS03765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AN401_RS03810	COG3048	D-serine ammonia-lyase activity
AN401_RS03815	COG1115	amino acid carrier protein
AN401_RS03820	COG1444	tRNA N-acetyltransferase activity
AN401_RS03830	COG2190	(PTS) system
AN401_RS03835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AN401_RS03840	COG2989	Protein conserved in bacteria
AN401_RS03845	COG3108	Peptidase M15
AN401_RS03855	COG3115	cell septum assembly
AN401_RS03860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AN401_RS03870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN401_RS03895	COG2818	Glycosylase
AN401_RS03905	COG4181	ATPase activity
AN401_RS03910	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AN401_RS03920	COG1090	epimerase
AN401_RS03930	COG0857	belongs to the CobB CobQ family
AN401_RS03930	COG0280	phosphate acetyltransferase
AN401_RS03940	COG3092	negative regulation of chromosome organization
AN401_RS03950	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AN401_RS03955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN401_RS03960	COG1053	succinate dehydrogenase
AN401_RS03970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_RS03975	COG1027	Aspartate ammonia-lyase
AN401_RS03980	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AN401_RS03995	COG1115	amino acid carrier protein
AN401_RS04000	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS04030	COG1404	Belongs to the peptidase S8 family
AN401_RS04075	COG3657	addiction module killer protein
AN401_RS04080	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN401_RS04095	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AN401_RS04100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN401_RS04105	COG2264	protein methyltransferase activity
AN401_RS04110	COG4145	pantothenate transmembrane transporter activity
AN401_RS04115	COG3924	membrane
AN401_RS04120	COG0251	oxidation-reduction process
AN401_RS04125	COG0439	Biotin carboxylase
AN401_RS04130	COG0511	ligase activity, forming carbon-carbon bonds
AN401_RS04135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AN401_RS04140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN401_RS04145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN401_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS04180	COG1238	metal cluster binding
AN401_RS04195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN401_RS04200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AN401_RS04205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN401_RS04205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN401_RS04245	COG0400	carboxylic ester hydrolase activity
AN401_RS04260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AN401_RS04265	COG1882	Formate acetyltransferase
AN401_RS04270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AN401_RS04275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN401_RS04280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN401_RS04285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AN401_RS04290	COG4172	Belongs to the ABC transporter superfamily
AN401_RS04295	COG0747	negative chemotaxis
AN401_RS04300	COG0601	transmembrane transport
AN401_RS04305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_RS04325	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AN401_RS04330	COG2840	Smr protein MutS2
AN401_RS04350	COG0300	oxidoreductase activity
AN401_RS04390	COG0835	chemotaxis
AN401_RS04390	COG0784	Response regulator, receiver
AN401_RS04395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AN401_RS04400	COG1815	bacterial-type flagellum-dependent cell motility
AN401_RS04420	COG4787	bacterial-type flagellum-dependent cell motility
AN401_RS04425	COG4786	Flagellar basal body rod
AN401_RS04430	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AN401_RS04435	COG1706	bacterial-type flagellum-dependent cell motility
AN401_RS04440	COG1705	Flagellar rod assembly protein muramidase FlgJ
AN401_RS04440	COG3951	Flagellar rod assembly protein muramidase FlgJ
AN401_RS04455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN401_RS04460	COG1334	flagellar protein FlaG
AN401_RS04465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AN401_RS04475	COG1516	flagellar protein fliS
AN401_RS04495	COG1677	Flagellar hook-basal body complex protein FliE
AN401_RS04505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AN401_RS04555	COG1987	bacterial-type flagellum assembly
AN401_RS04560	COG1684	flagellar biosynthetic protein fliR
AN401_RS04595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AN401_RS04600	COG0784	Response regulator, receiver
AN401_RS04600	COG2198	Histidine kinase
AN401_RS04600	COG0643	Histidine kinase
AN401_RS04605	COG2201	protein-glutamate methylesterase activity
AN401_RS04610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN401_RS04620	COG1192	Involved in chromosome partitioning
AN401_RS04630	COG0835	chemotaxis
AN401_RS04640	COG4133	protoheme IX ABC transporter activity
AN401_RS04645	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN401_RS04650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN401_RS04655	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AN401_RS04660	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AN401_RS04665	COG1138	Cytochrome C-type biogenesis protein
AN401_RS04670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN401_RS04690	COG1396	sequence-specific DNA binding
AN401_RS04695	COG3135	benzoate transporter
AN401_RS04705	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AN401_RS04730	COG3098	single-species biofilm formation
AN401_RS04735	COG0564	pseudouridine synthase activity
AN401_RS04740	COG2066	Belongs to the glutaminase family
AN401_RS04755	COG0471	metal ion transport
AN401_RS04755	COG3273	potassium ion transport
AN401_RS04770	COG0513	Belongs to the DEAD box helicase family
AN401_RS04775	COG2171	N-acyltransferase activity
AN401_RS04780	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AN401_RS04785	COG1609	Transcriptional regulator
AN401_RS04790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_RS04790	COG1263	PTS System
AN401_RS04795	COG0366	Alpha amylase catalytic
AN401_RS04800	COG0393	Putative heavy-metal-binding
AN401_RS04810	COG1278	Cold shock
AN401_RS04815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN401_RS04825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AN401_RS04830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AN401_RS04835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AN401_RS04845	COG0659	secondary active sulfate transmembrane transporter activity
AN401_RS04850	COG0492	ferredoxin-NADP+ reductase activity
AN401_RS04860	COG1674	ftsk spoiiie
AN401_RS04860	COG0531	amino acid
AN401_RS04865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AN401_RS04870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN401_RS04875	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AN401_RS04885	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN401_RS04890	COG1286	toxin biosynthetic process
AN401_RS04895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AN401_RS04910	COG2267	carboxylic ester hydrolase activity
AN401_RS04920	COG5001	Diguanylate cyclase
AN401_RS04920	COG3300	MHYT domain
AN401_RS04945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AN401_RS04965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AN401_RS04970	COG2867	negative regulation of translational initiation
AN401_RS04975	COG2914	Belongs to the UPF0125 (RnfH) family
AN401_RS04980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_RS04990	COG0497	DNA recombination
AN401_RS04995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN401_RS05000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AN401_RS05005	COG0443	Heat shock 70 kDa protein
AN401_RS05010	COG0484	heat shock protein binding
AN401_RS05025	COG1534	Rna-binding protein
AN401_RS05030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AN401_RS05040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AN401_RS05045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN401_RS05050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AN401_RS05065	COG0779	Required for maturation of 30S ribosomal subunits
AN401_RS05070	COG0195	Participates in both transcription termination and antitermination
AN401_RS05075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AN401_RS05080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AN401_RS05085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN401_RS05090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AN401_RS05095	COG3384	dioxygenase
AN401_RS05100	COG1185	polyribonucleotide nucleotidyltransferase activity
AN401_RS05105	COG0826	peptidase U32
AN401_RS05110	COG3111	PFAM Bacterial OB fold (BOF) protein
AN401_RS05115	COG0642	Histidine kinase
AN401_RS05120	COG0745	RESPONSE REGULATOR receiver
AN401_RS05145	COG3139	Protein of unknown function (DUF1315)
AN401_RS05150	COG3272	Protein of unknown function (DUF1722)
AN401_RS05155	COG0789	Transcriptional regulator
AN401_RS05160	COG0415	Belongs to the DNA photolyase family
AN401_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS05185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN401_RS05205	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AN401_RS05215	COG0788	formyltetrahydrofolate deformylase activity
AN401_RS05220	COG3012	SEC-C Motif Domain Protein
AN401_RS05240	COG1940	carbohydrate kinase activity
AN401_RS05245	COG0545	Peptidyl-prolyl cis-trans isomerase
AN401_RS05250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AN401_RS05255	COG0505	Belongs to the CarA family
AN401_RS05260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AN401_RS05265	COG1278	Cold shock
AN401_RS05275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN401_RS05280	COG1678	Uncharacterized ACR, COG1678
AN401_RS05285	COG0189	ligase activity
AN401_RS05290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN401_RS05300	COG0678	peroxiredoxin activity
AN401_RS05305	COG3091	SprT-like family
AN401_RS05310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AN401_RS05315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AN401_RS05320	COG2205	protein histidine kinase activity
AN401_RS05350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AN401_RS05355	COG2716	regulation of RNA biosynthetic process
AN401_RS05365	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AN401_RS05370	COG0417	DNA replication proofreading
AN401_RS05380	COG1876	peptidase activity
AN401_RS05385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AN401_RS05390	COG1393	Belongs to the ArsC family
AN401_RS05395	COG3706	GGDEF domain
AN401_RS05400	COG0281	malic enzyme
AN401_RS05405	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS05405	COG1454	alcohol dehydrogenase
AN401_RS05415	COG0601	transmembrane transport
AN401_RS05420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_RS05435	COG0544	peptidyl-prolyl cis-trans isomerase activity
AN401_RS05440	COG0740	serine-type endopeptidase activity
AN401_RS05445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AN401_RS05450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AN401_RS05455	COG0776	regulation of translation
AN401_RS05460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN401_RS05465	COG2197	response regulator
AN401_RS05470	COG0322	excinuclease ABC activity
AN401_RS05475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AN401_RS05505	COG3284	Transcriptional regulator
AN401_RS05515	COG1454	alcohol dehydrogenase
AN401_RS05530	COG1126	abc transporter atp-binding protein
AN401_RS05535	COG0765	amino acid transport
AN401_RS05540	COG4597	amino acid ABC transporter
AN401_RS05545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_RS05560	COG3842	ATPase activity
AN401_RS05625	COG1054	Belongs to the UPF0176 family
AN401_RS05630	COG0583	DNA-binding transcription factor activity
AN401_RS05650	COG1280	lysine exporter protein (LysE YggA)
AN401_RS05655	COG0840	transmembrane signaling receptor activity
AN401_RS05660	COG2951	lytic endotransglycosylase activity
AN401_RS05675	COG1283	sodium-dependent phosphate transmembrane transporter activity
AN401_RS05695	COG0737	Belongs to the 5'-nucleotidase family
AN401_RS05700	COG3264	Mechanosensitive ion channel
AN401_RS05700	COG1196	nuclear chromosome segregation
AN401_RS05715	COG1473	amidohydrolase
AN401_RS05720	COG2423	ornithine cyclodeaminase activity
AN401_RS05725	COG0154	amidase activity
AN401_RS05730	COG1115	amino acid carrier protein
AN401_RS05755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AN401_RS05760	COG0372	Belongs to the citrate synthase family
AN401_RS05765	COG2079	MmgE PrpD family protein
AN401_RS05780	COG0829	nickel cation binding
AN401_RS05785	COG0831	urea catabolic process
AN401_RS05790	COG0832	Belongs to the urease beta subunit family
AN401_RS05795	COG0804	urea catabolic process
AN401_RS05800	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AN401_RS05805	COG0830	nickel cation binding
AN401_RS05810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AN401_RS05820	COG2252	PERMEase
AN401_RS05825	COG1966	Carbon starvation protein
AN401_RS05830	COG3279	Response regulator of the LytR AlgR family
AN401_RS05835	COG3275	phosphorelay sensor kinase activity
AN401_RS05840	COG0017	Asparaginyl-tRNA synthetase
AN401_RS05890	COG4964	Belongs to the GSP D family
AN401_RS05940	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AN401_RS05955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AN401_RS05965	COG0083	homoserine kinase activity
AN401_RS05970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN401_RS05975	COG1946	Acyl-CoA thioesterase
AN401_RS05980	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AN401_RS05990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN401_RS05995	COG1115	amino acid carrier protein
AN401_RS06010	COG0727	PFAM Uncharacterised protein family (UPF0153)
AN401_RS06015	COG3132	Protein of unknown function, DUF480
AN401_RS06055	COG1061	Type III restriction enzyme res subunit
AN401_RS06070	COG3311	Transcriptional regulator
AN401_RS06075	COG1569	PIN domain
AN401_RS06085	COG0159	tryptophan synthase activity
AN401_RS06090	COG0133	tryptophan synthase activity
AN401_RS06095	COG0134	indole-3-glycerol-phosphate synthase activity
AN401_RS06095	COG0135	phosphoribosylanthranilate isomerase activity
AN401_RS06100	COG0512	Glutamine amidotransferase of anthranilate synthase
AN401_RS06100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AN401_RS06105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN401_RS06115	COG0009	L-threonylcarbamoyladenylate synthase
AN401_RS06120	COG1187	pseudouridine synthase activity
AN401_RS06140	COG0500	methyltransferase
AN401_RS06145	COG4106	trans-aconitate 2-methyltransferase activity
AN401_RS06150	COG1801	Protein of unknown function DUF72
AN401_RS06155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AN401_RS06160	COG0494	nUDIX hydrolase
AN401_RS06170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AN401_RS06175	COG0632	four-way junction helicase activity
AN401_RS06180	COG2255	four-way junction helicase activity
AN401_RS06185	COG0824	Thioesterase
AN401_RS06190	COG0811	peptide transport
AN401_RS06200	COG3064	Membrane
AN401_RS06205	COG0823	Involved in the tonB-independent uptake of proteins
AN401_RS06210	COG2885	chlorophyll binding
AN401_RS06215	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AN401_RS06280	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AN401_RS06285	COG2974	May be involved in recombination
AN401_RS06295	COG0745	RESPONSE REGULATOR receiver
AN401_RS06300	COG5002	protein histidine kinase activity
AN401_RS06310	COG0798	PFAM Bile acid sodium symporter
AN401_RS06320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN401_RS06340	COG0590	tRNA wobble adenosine to inosine editing
AN401_RS06350	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AN401_RS06360	COG0573	inorganic phosphate transmembrane transporter activity
AN401_RS06365	COG0573	inorganic phosphate transmembrane transporter activity
AN401_RS06370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN401_RS06375	COG0704	Plays a role in the regulation of phosphate uptake
AN401_RS06385	COG0673	inositol 2-dehydrogenase activity
AN401_RS06390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_RS06395	COG3962	Belongs to the TPP enzyme family
AN401_RS06410	COG3300	MHYT domain
AN401_RS06410	COG5001	Diguanylate cyclase
AN401_RS06420	COG0477	Major facilitator Superfamily
AN401_RS06425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN401_RS06430	COG0126	phosphoglycerate kinase activity
AN401_RS06450	COG5001	Diguanylate cyclase
AN401_RS06465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_RS06495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN401_RS06510	COG1538	Outer membrane efflux protein
AN401_RS06545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_RS06555	COG0189	ligase activity
AN401_RS06565	COG3585	molybdate ion transport
AN401_RS06565	COG2005	Transcriptional regulator
AN401_RS06570	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AN401_RS06585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AN401_RS06590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AN401_RS06595	COG4628	conserved protein (DUF2132)
AN401_RS06615	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AN401_RS06620	COG3079	Belongs to the UPF0149 family
AN401_RS06625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_RS06630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_RS06635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AN401_RS06640	COG0509	glycine decarboxylation via glycine cleavage system
AN401_RS06645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN401_RS06645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AN401_RS06665	COG3360	Dodecin
AN401_RS06670	COG4565	transcriptional regulatory protein
AN401_RS06675	COG3290	protein histidine kinase activity
AN401_RS06680	COG0747	negative chemotaxis
AN401_RS06700	COG0745	RESPONSE REGULATOR receiver
AN401_RS06705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AN401_RS06710	COG1555	photosystem II stabilization
AN401_RS06715	COG2350	Protein conserved in bacteria
AN401_RS06720	COG2917	probably involved in intracellular septation
AN401_RS06730	COG0673	inositol 2-dehydrogenase activity
AN401_RS06750	COG1129	ABC transporter
AN401_RS06760	COG2814	Major facilitator Superfamily
AN401_RS06760	COG0477	Major facilitator Superfamily
AN401_RS06775	COG0673	inositol 2-dehydrogenase activity
AN401_RS06785	COG3718	enzyme involved in inositol metabolism
AN401_RS06790	COG0673	inositol 2-dehydrogenase activity
AN401_RS06805	COG3551	Protein conserved in bacteria
AN401_RS06815	COG1214	PFAM Peptidase M22, glycoprotease
AN401_RS06815	COG0456	acetyltransferase
AN401_RS06840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS06850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS06855	COG0583	DNA-binding transcription factor activity
AN401_RS06860	COG0697	spore germination
AN401_RS06865	COG1609	Transcriptional regulator
AN401_RS06870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_RS06875	COG1879	ABC-type sugar transport system periplasmic component
AN401_RS06880	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN401_RS06885	COG1129	ABC transporter
AN401_RS06890	COG1869	D-ribose catabolic process
AN401_RS06905	COG4172	Belongs to the ABC transporter superfamily
AN401_RS06910	COG4172	Belongs to the ABC transporter superfamily
AN401_RS06915	COG4171	peptide transport system, permease
AN401_RS06920	COG4168	peptide transport system, permease
AN401_RS06925	COG4166	transmembrane transport
AN401_RS06930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AN401_RS06935	COG1842	Phage shock protein A
AN401_RS06950	COG3106	COG3106 Predicted ATPase
AN401_RS06955	COG3768	UPF0283 membrane protein
AN401_RS06975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AN401_RS06980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_RS06995	COG0215	cysteine-tRNA ligase activity
AN401_RS07000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AN401_RS07005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_RS07010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AN401_RS07035	COG1607	acyl-coa hydrolase
AN401_RS07040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_RS07055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN401_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS07090	COG3383	formate dehydrogenase (NAD+) activity
AN401_RS07095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AN401_RS07235	COG1426	Protein conserved in bacteria
AN401_RS07305	COG4383	Mu-like prophage protein gp29
AN401_RS07320	COG4388	Caudovirus prohead serine protease
AN401_RS07330	COG4397	Mu-like prophage major head subunit gpT
AN401_RS07400	COG1017	nitric oxide dioxygenase activity
AN401_RS07400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_RS07405	COG4638	Rieske (2fe-2S)
AN401_RS07455	COG1902	pentaerythritol trinitrate reductase activity
AN401_RS07455	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN401_RS07460	COG2181	nitrate reductase activity
AN401_RS07460	COG0247	lactate metabolic process
AN401_RS07465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AN401_RS07520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN401_RS07535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_RS07540	COG0840	transmembrane signaling receptor activity
AN401_RS07545	COG2116	formate transmembrane transporter activity
AN401_RS07550	COG2056	Na+-H+ antiporter family
AN401_RS07555	COG0450	alkyl hydroperoxide reductase
AN401_RS07570	COG1119	ATPase activity
AN401_RS07585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN401_RS07600	COG0583	DNA-binding transcription factor activity
AN401_RS07635	COG2062	phosphohistidine phosphatase, SixA
AN401_RS07645	COG2840	Smr protein MutS2
AN401_RS07650	COG2890	protein-(glutamine-N5) methyltransferase activity
AN401_RS07655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AN401_RS07660	COG3101	peptidyl-lysine hydroxylation
AN401_RS07680	COG0175	sulfate reduction
AN401_RS07685	COG0471	metal ion transport
AN401_RS07685	COG3273	potassium ion transport
AN401_RS07695	COG0745	RESPONSE REGULATOR receiver
AN401_RS07700	COG2132	Multicopper oxidase
AN401_RS07735	COG2217	Heavy metal translocating P-type atpase
AN401_RS07740	COG2205	protein histidine kinase activity
AN401_RS07750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_RS07755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_RS07780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_RS07810	COG1595	DNA-templated transcription, initiation
AN401_RS07820	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AN401_RS07830	COG1609	Transcriptional regulator
AN401_RS07840	COG0673	inositol 2-dehydrogenase activity
AN401_RS07845	COG0673	inositol 2-dehydrogenase activity
AN401_RS07860	COG2706	6-phosphogluconolactonase activity
AN401_RS07875	COG3622	Belongs to the hyi family
AN401_RS07885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_RS07890	COG0473	3-isopropylmalate dehydrogenase activity
AN401_RS07895	COG3395	kinase activity
AN401_RS07900	COG0235	Class ii aldolase
AN401_RS07905	COG0583	DNA-binding transcription factor activity
AN401_RS07915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_RS07965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN401_RS07995	COG1609	Transcriptional regulator
AN401_RS08005	COG0471	metal ion transport
AN401_RS08010	COG0583	DNA-binding transcription factor activity
AN401_RS08020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AN401_RS08030	COG1522	sequence-specific DNA binding
AN401_RS08055	COG1494	fructose-1,6-bisphosphatase
AN401_RS08060	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN401_RS08065	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AN401_RS08070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN401_RS08075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN401_RS08080	COG1349	DNA-binding transcription factor activity
AN401_RS08085	COG1879	ABC-type sugar transport system periplasmic component
AN401_RS08090	COG1172	Belongs to the binding-protein-dependent transport system permease family
AN401_RS08095	COG1129	ABC transporter
AN401_RS08120	COG1454	alcohol dehydrogenase
AN401_RS08130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AN401_RS08140	COG1349	DNA-binding transcription factor activity
AN401_RS08145	COG0149	triose-phosphate isomerase activity
AN401_RS08160	COG2376	Dihydroxyacetone kinase
AN401_RS08165	COG0698	ribose 5-phosphate isomerase
AN401_RS08170	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS08175	COG2186	Transcriptional regulator
AN401_RS08180	COG3959	Transketolase, thiamine diphosphate binding domain
AN401_RS08185	COG3958	Transketolase
AN401_RS08190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS08200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS08205	COG2084	Dehydrogenase
AN401_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS08230	COG2832	Protein of unknown function (DUF454)
AN401_RS08235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AN401_RS08240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AN401_RS08245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AN401_RS08250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN401_RS08260	COG0295	cytidine deaminase activity
AN401_RS08265	COG1346	cytolysis
AN401_RS08270	COG1380	Effector of murein hydrolase LrgA
AN401_RS08275	COG2925	Exonuclease
AN401_RS08285	COG1278	Cold shock
AN401_RS08295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AN401_RS08300	COG0662	Cupin 2, conserved barrel domain protein
AN401_RS08305	COG0527	aspartate kinase activity
AN401_RS08310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN401_RS08315	COG3593	DNA synthesis involved in DNA repair
AN401_RS08325	COG2814	Major facilitator Superfamily
AN401_RS08335	COG3133	Outer membrane lipoprotein
AN401_RS08345	COG1643	Atp-dependent helicase
AN401_RS08350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AN401_RS08385	COG1247	-acetyltransferase
AN401_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS08430	COG5433	transposase activity
AN401_RS08455	COG3040	lipid binding
AN401_RS08470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN401_RS08480	COG0789	Transcriptional regulator
AN401_RS08485	COG2259	Doxx family
AN401_RS08520	COG0668	transmembrane transport
AN401_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS08540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_RS08545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_RS08560	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AN401_RS08565	COG1074	ATP-dependent DNA helicase activity
AN401_RS08570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN401_RS08580	COG0590	tRNA wobble adenosine to inosine editing
AN401_RS08605	COG0784	Response regulator, receiver
AN401_RS08605	COG2205	protein histidine kinase activity
AN401_RS08605	COG5002	protein histidine kinase activity
AN401_RS08610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN401_RS08620	COG0384	phenazine biosynthesis protein PhzF
AN401_RS08635	COG2814	Major facilitator Superfamily
AN401_RS08640	COG0367	asparagine synthase
AN401_RS08675	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN401_RS08680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_RS08695	COG0488	(ABC) transporter
AN401_RS08700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AN401_RS08710	COG0589	response to stress
AN401_RS08715	COG0659	secondary active sulfate transmembrane transporter activity
AN401_RS08725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN401_RS08725	COG4651	solute:proton antiporter activity
AN401_RS08740	COG0647	UMP catabolic process
AN401_RS08745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN401_RS08750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AN401_RS08755	COG2885	chlorophyll binding
AN401_RS08760	COG0730	response to heat
AN401_RS08765	COG1560	Kdo2-lipid A biosynthetic process
AN401_RS08775	COG4067	protein conserved in archaea
AN401_RS08775	COG0189	ligase activity
AN401_RS08785	COG0733	neurotransmitter:sodium symporter activity
AN401_RS08795	COG0471	metal ion transport
AN401_RS08800	COG2205	protein histidine kinase activity
AN401_RS08800	COG3850	Histidine kinase
AN401_RS08800	COG3437	response regulator, receiver
AN401_RS08800	COG4999	Histidine kinase
AN401_RS08805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_RS08820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_RS08830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AN401_RS08835	COG1349	DNA-binding transcription factor activity
AN401_RS08840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN401_RS08855	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AN401_RS08870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN401_RS08905	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AN401_RS08910	COG0709	Synthesizes selenophosphate from selenide and ATP
AN401_RS08915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AN401_RS08920	COG1254	Belongs to the acylphosphatase family
AN401_RS08930	COG3550	peptidyl-serine autophosphorylation
AN401_RS08945	COG0494	nUDIX hydrolase
AN401_RS08950	COG1760	l-serine dehydratase
AN401_RS08955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN401_RS08955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN401_RS08960	COG0837	glucose binding
AN401_RS08970	COG2205	protein histidine kinase activity
AN401_RS08980	COG1175	transmembrane transport
AN401_RS08985	COG0395	ABC-type sugar transport system, permease component
AN401_RS08990	COG3842	ATPase activity
AN401_RS09000	COG0572	uridine kinase
AN401_RS09005	COG0717	Belongs to the dCTP deaminase family
AN401_RS09020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN401_RS09025	COG1530	ribonuclease E activity
AN401_RS09030	COG0564	pseudouridine synthase activity
AN401_RS09035	COG0546	phosphoglycolate phosphatase activity
AN401_RS09045	COG1399	metal-binding, possibly nucleic acid-binding protein
AN401_RS09050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AN401_RS09055	COG0416	fatty acid biosynthetic process
AN401_RS09060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN401_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS09075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AN401_RS09085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN401_RS09090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AN401_RS09095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AN401_RS09100	COG0470	DNA polymerase III
AN401_RS09105	COG0084	hydrolase, TatD family'
AN401_RS09115	COG0330	HflC and HflK could
AN401_RS09120	COG3141	response to X-ray
AN401_RS09130	COG1956	GAF domain-containing protein
AN401_RS09135	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AN401_RS09145	COG0308	aminopeptidase N
AN401_RS09155	COG2902	Dehydrogenase
AN401_RS09160	COG0167	dihydroorotate dehydrogenase activity
AN401_RS09190	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AN401_RS09190	COG0116	Belongs to the methyltransferase superfamily
AN401_RS09200	COG0488	(ABC) transporter
AN401_RS09210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN401_RS09215	COG1067	ATP-dependent peptidase activity
AN401_RS09220	COG0671	phosphoesterase, PA-phosphatase related
AN401_RS09240	COG0011	TIGRFAM Protein of
AN401_RS09250	COG4804	nuclease activity
AN401_RS09270	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AN401_RS09290	COG4974	Belongs to the 'phage' integrase family
AN401_RS09295	COG0318	PFAM AMP-dependent synthetase and ligase
AN401_RS09325	COG0095	Lipoate-protein ligase
AN401_RS09340	COG0022	dehydrogenase e1 component
AN401_RS09345	COG1063	alcohol dehydrogenase
AN401_RS09350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AN401_RS09355	COG3284	Transcriptional regulator
AN401_RS09365	COG3278	Belongs to the heme-copper respiratory oxidase family
AN401_RS09380	COG2010	Cytochrome c
AN401_RS09390	COG2217	Heavy metal translocating P-type atpase
AN401_RS09405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN401_RS09415	COG0037	tRNA processing
AN401_RS09430	COG3842	ATPase activity
AN401_RS09440	COG1177	transmembrane transport
AN401_RS09445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN401_RS09450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN401_RS09455	COG0776	regulation of translation
AN401_RS09465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AN401_RS09470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AN401_RS09475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AN401_RS09480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AN401_RS09485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AN401_RS09495	COG3001	Fructosamine kinase
AN401_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS09510	COG0307	riboflavin synthase, alpha
AN401_RS09540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AN401_RS09545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AN401_RS09550	COG2766	serine protein kinase
AN401_RS09555	COG2718	Belongs to the UPF0229 family
AN401_RS09560	COG2719	SpoVR family
AN401_RS09570	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AN401_RS09575	COG2983	Belongs to the UPF0260 family
AN401_RS09580	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN401_RS09585	COG3100	YcgL domain-containing protein
AN401_RS09590	COG0850	regulation of cytokinetic process
AN401_RS09595	COG2894	cell division
AN401_RS09600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AN401_RS09605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AN401_RS09610	COG0318	PFAM AMP-dependent synthetase and ligase
AN401_RS09620	COG1199	ATP-dependent helicase activity
AN401_RS09675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN401_RS09680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN401_RS09685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN401_RS09690	COG0131	Imidazoleglycerol-phosphate dehydratase
AN401_RS09690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AN401_RS09695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN401_RS09700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AN401_RS09705	COG0107	imidazoleglycerol-phosphate synthase activity
AN401_RS09710	COG0140	phosphoribosyl-ATP diphosphatase activity
AN401_RS09710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AN401_RS09720	COG2814	Major facilitator Superfamily
AN401_RS09725	COG1448	Aminotransferase
AN401_RS09755	COG2995	paraquat-inducible protein a
AN401_RS09760	COG3008	intermembrane lipid transfer
AN401_RS09760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN401_RS09775	COG0697	spore germination
AN401_RS09810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN401_RS09825	COG0840	transmembrane signaling receptor activity
AN401_RS09830	COG0456	acetyltransferase
AN401_RS09840	COG0456	acetyltransferase
AN401_RS09840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AN401_RS09860	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AN401_RS09865	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AN401_RS09870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN401_RS09875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AN401_RS09885	COG0205	6-phosphofructokinase activity
AN401_RS09900	COG2878	Part of a membrane complex involved in electron transport
AN401_RS09905	COG4656	Part of a membrane complex involved in electron transport
AN401_RS09910	COG4658	electron transport chain
AN401_RS09915	COG4659	FMN binding
AN401_RS09920	COG4660	Part of a membrane complex involved in electron transport
AN401_RS09925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AN401_RS09945	COG0346	lactoylglutathione lyase activity
AN401_RS09965	COG2814	Major facilitator Superfamily
AN401_RS09970	COG0583	DNA-binding transcription factor activity
AN401_RS09980	COG1136	(ABC) transporter
AN401_RS09995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN401_RS10010	COG1199	ATP-dependent helicase activity
AN401_RS10015	COG0730	response to heat
AN401_RS10020	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AN401_RS10030	COG3314	Sporulation integral membrane protein YlbJ
AN401_RS10035	COG0500	methyltransferase
AN401_RS10050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AN401_RS10055	COG0563	adenylate kinase activity
AN401_RS10060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN401_RS10065	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AN401_RS10070	COG0326	Molecular chaperone. Has ATPase activity
AN401_RS10080	COG0183	Belongs to the thiolase family
AN401_RS10095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_RS10100	COG2067	long-chain fatty acid transport protein
AN401_RS10105	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AN401_RS10115	COG1757	Na H antiporter
AN401_RS10130	COG0284	orotidine-5'-phosphate decarboxylase activity
AN401_RS10135	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AN401_RS10140	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AN401_RS10145	COG0776	regulation of translation
AN401_RS10150	COG0539	negative regulation of cytoplasmic translation
AN401_RS10155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AN401_RS10160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN401_RS10175	COG0022	dehydrogenase e1 component
AN401_RS10175	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN401_RS10180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AN401_RS10185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN401_RS10215	COG0375	protein maturation
AN401_RS10220	COG0309	Hydrogenase expression formation protein (HypE)
AN401_RS10225	COG0409	Hydrogenase expression formation protein
AN401_RS10240	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AN401_RS10240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN401_RS10240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN401_RS10245	COG1105	Belongs to the carbohydrate kinase PfkB family
AN401_RS10250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_RS10250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN401_RS10265	COG0564	pseudouridine synthase activity
AN401_RS10275	COG0670	Belongs to the BI1 family
AN401_RS10280	COG1289	transmembrane transporter activity
AN401_RS10285	COG2920	part of a sulfur-relay system
AN401_RS10290	COG3850	Histidine kinase
AN401_RS10295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AN401_RS10305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN401_RS10310	COG1737	Transcriptional regulator
AN401_RS10315	COG0469	pyruvate kinase activity
AN401_RS10335	COG1166	arginine decarboxylase activity
AN401_RS10340	COG4667	esterase of the alpha-beta hydrolase superfamily
AN401_RS10365	COG0583	DNA-binding transcription factor activity
AN401_RS10370	COG0302	gtp cyclohydrolase
AN401_RS10375	COG0303	'Molybdopterin
AN401_RS10380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AN401_RS10385	COG0602	queuosine metabolic process
AN401_RS10390	COG0720	synthase
AN401_RS10395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AN401_RS10400	COG0574	Belongs to the PEP-utilizing enzyme family
AN401_RS10400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN401_RS10405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AN401_RS10415	COG3833	ABC-type maltose transport systems, permease component
AN401_RS10420	COG1175	transmembrane transport
AN401_RS10435	COG0366	Alpha amylase catalytic
AN401_RS10445	COG4580	involved in the transport of maltose and maltodextrins
AN401_RS10455	COG2909	trisaccharide binding
AN401_RS10465	COG3833	ABC-type maltose transport systems, permease component
AN401_RS10470	COG1175	transmembrane transport
AN401_RS10475	COG2182	Extracellular solute-binding protein
AN401_RS10480	COG3842	ATPase activity
AN401_RS10485	COG0366	Alpha amylase catalytic
AN401_RS10495	COG1609	Transcriptional regulator
AN401_RS10500	COG1263	PTS System
AN401_RS10500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_RS10510	COG3123	guanosine phosphorylase activity
AN401_RS10515	COG0366	Alpha amylase catalytic
AN401_RS10520	COG0366	Alpha amylase catalytic
AN401_RS10525	COG3842	ATPase activity
AN401_RS10545	COG1653	transport
AN401_RS10550	COG0583	DNA-binding transcription factor activity
AN401_RS10555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_RS10555	COG1263	PTS System
AN401_RS10565	COG2308	Evidence 4 Homologs of previously reported genes of
AN401_RS10585	COG2133	pyrroloquinoline quinone binding
AN401_RS10595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_RS10600	COG3263	regulation of cellular component size
AN401_RS10605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN401_RS10630	COG1492	cobalamin metabolic process
AN401_RS10635	COG5507	3-demethylubiquinone-9 3-methyltransferase
AN401_RS10640	COG3795	YCII-related domain
AN401_RS10645	COG3795	YCII-related domain
AN401_RS10650	COG4941	Belongs to the sigma-70 factor family
AN401_RS10655	COG1283	sodium-dependent phosphate transmembrane transporter activity
AN401_RS10670	COG1522	sequence-specific DNA binding
AN401_RS10680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_RS10690	COG0693	protein deglycase activity
AN401_RS10695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AN401_RS10700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AN401_RS10715	COG5001	Diguanylate cyclase
AN401_RS10715	COG3300	MHYT domain
AN401_RS10725	COG0625	glutathione transferase activity
AN401_RS10750	COG1881	PFAM PEBP family protein
AN401_RS10780	COG1793	dna ligase
AN401_RS10785	COG2807	transmembrane transport
AN401_RS10790	COG0746	molybdenum cofactor guanylyltransferase activity
AN401_RS10795	COG0778	Nitroreductase
AN401_RS10800	COG1902	pentaerythritol trinitrate reductase activity
AN401_RS10800	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN401_RS10805	COG0616	signal peptide processing
AN401_RS10810	COG0252	asparaginase activity
AN401_RS10825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN401_RS10830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AN401_RS10840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN401_RS10850	COG4139	cobalamin transport
AN401_RS10855	COG0583	DNA-binding transcription factor activity
AN401_RS10860	COG0730	response to heat
AN401_RS10865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AN401_RS10880	COG0189	ligase activity
AN401_RS10905	COG0667	Aldo Keto reductase
AN401_RS10910	COG0402	S-adenosylhomocysteine deaminase activity
AN401_RS10960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AN401_RS10975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_RS10975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AN401_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS10990	COG4638	Rieske (2fe-2S)
AN401_RS10995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN401_RS11000	COG0583	DNA-binding transcription factor activity
AN401_RS11010	COG0405	Gamma-glutamyltransferase
AN401_RS11015	COG2807	transmembrane transport
AN401_RS11025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_RS11030	COG1120	ATPase activity
AN401_RS11040	COG0583	DNA-binding transcription factor activity
AN401_RS11045	COG0513	Belongs to the DEAD box helicase family
AN401_RS11060	COG2957	Belongs to the agmatine deiminase family
AN401_RS11070	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AN401_RS11075	COG0285	dihydrofolate synthase activity
AN401_RS11080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AN401_RS11085	COG0101	tRNA pseudouridine synthase activity
AN401_RS11095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN401_RS11100	COG0671	phosphoesterase, PA-phosphatase related
AN401_RS11105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AN401_RS11110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_RS11110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AN401_RS11140	COG0556	nucleotide-excision repair
AN401_RS11150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN401_RS11155	COG5301	cellulose 1,4-beta-cellobiosidase activity
AN401_RS11165	COG3299	homolog of phage Mu protein gp47
AN401_RS11175	COG4384	Bacteriophage Mu Gp45 protein
AN401_RS11185	COG4228	DNA circulation
AN401_RS11190	COG3941	tape measure
AN401_RS11195	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
AN401_RS11215	COG4387	Mu-like prophage protein GP36
AN401_RS11230	COG4388	Caudovirus prohead serine protease
AN401_RS11285	COG4382	Mu-like prophage protein Gp16
AN401_RS11370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AN401_RS11370	COG1263	PTS System
AN401_RS11370	COG2190	(PTS) system
AN401_RS11375	COG0363	glucosamine-6-phosphate deaminase activity
AN401_RS11380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AN401_RS11385	COG1846	Transcriptional regulator
AN401_RS11385	COG1940	carbohydrate kinase activity
AN401_RS11390	COG0023	Translation Initiation Factor
AN401_RS11395	COG2119	membrane
AN401_RS11405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AN401_RS11405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN401_RS11410	COG0527	aspartate kinase activity
AN401_RS11415	COG3174	membrane
AN401_RS11420	COG0625	glutathione transferase activity
AN401_RS11425	COG0505	Belongs to the CarA family
AN401_RS11430	COG0686	Belongs to the AlaDH PNT family
AN401_RS11445	COG1177	transmembrane transport
AN401_RS11450	COG1176	ABC-type spermidine putrescine transport system, permease component I
AN401_RS11455	COG3842	ATPase activity
AN401_RS11460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AN401_RS11470	COG0174	glutamine synthetase
AN401_RS11475	COG0174	glutamine synthetase
AN401_RS11480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_RS11485	COG3313	Fe-S protein
AN401_RS11495	COG0314	molybdopterin synthase activity
AN401_RS11500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AN401_RS11505	COG0315	cyclic pyranopterin monophosphate synthase activity
AN401_RS11510	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN401_RS11515	COG3005	denitrification pathway
AN401_RS11525	COG0348	domain, Protein
AN401_RS11530	COG0437	4 iron, 4 sulfur cluster binding
AN401_RS11535	COG0243	molybdopterin cofactor binding
AN401_RS11545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN401_RS11550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN401_RS11555	COG2197	response regulator
AN401_RS11565	COG2204	response regulator
AN401_RS11570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN401_RS11595	COG0840	transmembrane signaling receptor activity
AN401_RS11610	COG3724	N-succinylarginine dihydrolase activity
AN401_RS11615	COG0616	signal peptide processing
AN401_RS11620	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS11625	COG0583	DNA-binding transcription factor activity
AN401_RS11630	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AN401_RS11635	COG2358	TRAP transporter, solute receptor (TAXI family
AN401_RS11670	COG2988	succinylglutamate desuccinylase activity
AN401_RS11675	COG0033	Phosphoglucomutase
AN401_RS11680	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AN401_RS11685	COG0596	Alpha beta hydrolase
AN401_RS11700	COG0716	FMN binding
AN401_RS11705	COG1376	ErfK ybiS ycfS ynhG family protein
AN401_RS11820	COG4382	Mu-like prophage protein Gp16
AN401_RS11825	COG5566	PFAM Mor transcription activator
AN401_RS11850	COG0640	Transcriptional regulator
AN401_RS11865	COG4383	Mu-like prophage protein gp29
AN401_RS11870	COG2369	cell adhesion
AN401_RS11890	COG4388	Caudovirus prohead serine protease
AN401_RS11900	COG4397	Mu-like prophage major head subunit gpT
AN401_RS11910	COG4387	Mu-like prophage protein GP36
AN401_RS11915	COG5003	unkown
AN401_RS11925	COG4386	tail sheath protein
AN401_RS11935	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
AN401_RS11940	COG3941	tape measure
AN401_RS11945	COG4228	DNA circulation
AN401_RS11955	COG4384	Bacteriophage Mu Gp45 protein
AN401_RS11965	COG3299	homolog of phage Mu protein gp47
AN401_RS11975	COG5301	cellulose 1,4-beta-cellobiosidase activity
AN401_RS11980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AN401_RS11995	COG4964	Belongs to the GSP D family
AN401_RS12035	COG0735	belongs to the Fur family
AN401_RS12040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN401_RS12055	COG0183	Belongs to the thiolase family
AN401_RS12100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN401_RS12105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AN401_RS12110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AN401_RS12120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN401_RS12125	COG0546	phosphoglycolate phosphatase activity
AN401_RS12130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN401_RS12135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN401_RS12140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_RS12170	COG4691	Plasmid stability protein
AN401_RS12175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN401_RS12240	COG4691	Plasmid stability protein
AN401_RS12275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AN401_RS12280	COG1074	ATP-dependent DNA helicase activity
AN401_RS12285	COG0582	viral genome integration into host DNA
AN401_RS12290	COG0519	Catalyzes the synthesis of GMP from XMP
AN401_RS12290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN401_RS12295	COG0516	GMP reductase activity
AN401_RS12295	COG0517	IMP dehydrogenase activity
AN401_RS12300	COG1570	exodeoxyribonuclease VII activity
AN401_RS12320	COG0045	succinate-CoA ligase (ADP-forming) activity
AN401_RS12325	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN401_RS12330	COG0567	Dehydrogenase, E1 component
AN401_RS12335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN401_RS12340	COG1053	succinate dehydrogenase
AN401_RS12345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AN401_RS12360	COG0071	Belongs to the small heat shock protein (HSP20) family
AN401_RS12365	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AN401_RS12370	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AN401_RS12375	COG2835	tetraacyldisaccharide 4'-kinase activity
AN401_RS12380	COG1663	tetraacyldisaccharide 4'-kinase activity
AN401_RS12390	COG0658	competence protein
AN401_RS12390	COG2333	competence protein COMEC
AN401_RS12405	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN401_RS12410	COG1136	(ABC) transporter
AN401_RS12415	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN401_RS12425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AN401_RS12450	COG0513	Belongs to the DEAD box helicase family
AN401_RS12460	COG1252	NADH dehydrogenase
AN401_RS12465	COG1472	Belongs to the glycosyl hydrolase 3 family
AN401_RS12480	COG0537	adenosine 5'-monophosphoramidase activity
AN401_RS12485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AN401_RS12530	COG0840	transmembrane signaling receptor activity
AN401_RS12545	COG0729	surface antigen
AN401_RS12550	COG1763	Mo-molybdopterin cofactor biosynthetic process
AN401_RS12565	COG1132	(ABC) transporter
AN401_RS12570	COG1132	(ABC) transporter
AN401_RS12585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AN401_RS12590	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AN401_RS12600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN401_RS12640	COG0501	Belongs to the peptidase M48B family
AN401_RS12645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AN401_RS12655	COG0156	8-amino-7-oxononanoate synthase activity
AN401_RS12660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AN401_RS12680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS12690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS12705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_RS12710	COG0625	glutathione transferase activity
AN401_RS12720	COG0583	DNA-binding transcription factor activity
AN401_RS12725	COG0583	DNA-binding transcription factor activity
AN401_RS12730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AN401_RS12735	COG1473	amidohydrolase
AN401_RS12770	COG3327	negative regulation of DNA-templated transcription, initiation
AN401_RS12775	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AN401_RS12780	COG0183	Belongs to the thiolase family
AN401_RS12785	COG2050	protein possibly involved in aromatic compounds catabolism
AN401_RS12790	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN401_RS12795	COG1024	Enoyl-CoA hydratase
AN401_RS12800	COG1024	Enoyl-CoA hydratase
AN401_RS12805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_RS12810	COG2151	metal-sulfur cluster biosynthetic enzyme
AN401_RS12815	COG3396	Phenylacetate-CoA oxygenase
AN401_RS12820	COG3460	Phenylacetate-CoA oxygenase
AN401_RS12825	COG3396	Phenylacetate-CoA oxygenase
AN401_RS12830	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS12830	COG2030	dehydratase
AN401_RS12835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN401_RS12840	COG0745	RESPONSE REGULATOR receiver
AN401_RS12855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AN401_RS12870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN401_RS12880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN401_RS12905	COG1086	Polysaccharide biosynthesis protein
AN401_RS12910	COG1216	Glycosyl transferase, family 2
AN401_RS12950	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AN401_RS12975	COG1720	tRNA m6t6A37 methyltransferase activity
AN401_RS12990	COG0037	tRNA processing
AN401_RS13000	COG0825	malonyl-CoA metabolic process
AN401_RS13005	COG0587	DNA-directed DNA polymerase activity
AN401_RS13010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN401_RS13015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_RS13020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_RS13025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AN401_RS13030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN401_RS13035	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AN401_RS13040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_RS13045	COG0750	zinc metalloprotease
AN401_RS13050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AN401_RS13055	COG0575	Belongs to the CDS family
AN401_RS13060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN401_RS13065	COG0233	cytoplasmic translational termination
AN401_RS13070	COG0528	UMP kinase activity
AN401_RS13075	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AN401_RS13080	COG0052	Belongs to the universal ribosomal protein uS2 family
AN401_RS13085	COG0024	Methionine aminopeptidase
AN401_RS13090	COG0538	isocitrate dehydrogenase activity
AN401_RS13095	COG1187	pseudouridine synthase activity
AN401_RS13105	COG0482	sulfurtransferase activity
AN401_RS13110	COG2915	High frequency lysogenization protein hflD homolog
AN401_RS13115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN401_RS13120	COG2850	peptidyl-arginine hydroxylation
AN401_RS13125	COG3153	acetyltransferase
AN401_RS13130	COG0259	pyridoxamine-phosphate oxidase activity
AN401_RS13135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN401_RS13140	COG2814	Major facilitator Superfamily
AN401_RS13150	COG0483	inositol monophosphate 1-phosphatase activity
AN401_RS13160	COG2050	protein possibly involved in aromatic compounds catabolism
AN401_RS13170	COG0247	lactate metabolic process
AN401_RS13170	COG0277	FAD linked oxidase domain protein
AN401_RS13180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN401_RS13185	COG1187	pseudouridine synthase activity
AN401_RS13205	COG3279	Response regulator of the LytR AlgR family
AN401_RS13210	COG3706	GGDEF domain
AN401_RS13225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AN401_RS13230	COG1061	Type III restriction enzyme res subunit
AN401_RS13235	COG2027	D-alanyl-D-alanine carboxypeptidase
AN401_RS13245	COG0436	Aminotransferase
AN401_RS13270	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AN401_RS13280	COG1160	GTP binding
AN401_RS13285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN401_RS13290	COG2976	Protein conserved in bacteria
AN401_RS13295	COG0124	histidyl-tRNA synthetase
AN401_RS13315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AN401_RS13320	COG0105	UTP biosynthetic process
AN401_RS13335	COG2975	iron-sulfur cluster assembly
AN401_RS13345	COG0443	Heat shock 70 kDa protein
AN401_RS13350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AN401_RS13355	COG0316	Belongs to the HesB IscA family
AN401_RS13360	COG0822	iron-sulfur transferase activity
AN401_RS13365	COG1104	cysteine desulfurase activity
AN401_RS13380	COG3154	lipid carrier protein
AN401_RS13385	COG0826	peptidase U32
AN401_RS13390	COG0826	peptidase U32
AN401_RS13400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN401_RS13405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN401_RS13410	COG1862	Preprotein translocase
AN401_RS13415	COG0343	queuine tRNA-ribosyltransferase activity
AN401_RS13420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AN401_RS13425	COG0517	IMP dehydrogenase activity
AN401_RS13435	COG0515	serine threonine protein kinase
AN401_RS13445	COG0022	dehydrogenase e1 component
AN401_RS13470	COG3634	alkyl hydroperoxide reductase activity
AN401_RS13475	COG0583	DNA-binding transcription factor activity
AN401_RS13480	COG3081	Nucleoid-associated protein
AN401_RS13495	COG0791	NLP P60 protein
AN401_RS13510	COG0733	neurotransmitter:sodium symporter activity
AN401_RS13520	COG0425	Belongs to the sulfur carrier protein TusA family
AN401_RS13525	COG4783	chaperone-mediated protein folding
AN401_RS13535	COG1393	Belongs to the ArsC family
AN401_RS13545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AN401_RS13555	COG2233	PERMEase
AN401_RS13560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AN401_RS13565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AN401_RS13570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN401_RS13580	COG1067	ATP-dependent peptidase activity
AN401_RS13585	COG0121	glutamine amidotransferase
AN401_RS13600	COG1960	acyl-CoA dehydrogenase activity
AN401_RS13605	COG1120	ATPase activity
AN401_RS13610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_RS13615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_RS13625	COG2207	Transcriptional regulator
AN401_RS13625	COG3708	Transcriptional regulator
AN401_RS13645	COG0456	acetyltransferase
AN401_RS13645	COG0454	-acetyltransferase
AN401_RS13665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_RS13670	COG0765	amino acid transport
AN401_RS13675	COG1126	abc transporter atp-binding protein
AN401_RS13680	COG2040	homocysteine
AN401_RS13685	COG1522	sequence-specific DNA binding
AN401_RS13695	COG2912	Transglutaminase-like superfamily
AN401_RS13700	COG2890	protein-(glutamine-N5) methyltransferase activity
AN401_RS13705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AN401_RS13710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AN401_RS13715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AN401_RS13720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AN401_RS13730	COG0730	response to heat
AN401_RS13735	COG0193	aminoacyl-tRNA hydrolase activity
AN401_RS13740	COG0012	GTP binding
AN401_RS13775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN401_RS13780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AN401_RS13785	COG1702	phosphate starvation-inducible protein PhoH
AN401_RS13790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AN401_RS13795	COG4535	Mg2 and Co2 transporter CorC
AN401_RS13800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AN401_RS13805	COG2888	peptidyl-tyrosine sulfation
AN401_RS13810	COG0495	leucyl-tRNA aminoacylation
AN401_RS13815	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AN401_RS13820	COG1466	dna polymerase III delta subunit
AN401_RS13825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AN401_RS13830	COG0799	negative regulation of ribosome biogenesis
AN401_RS13835	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AN401_RS13840	COG0768	penicillin binding
AN401_RS13845	COG0772	Belongs to the SEDS family
AN401_RS13850	COG2951	lytic endotransglycosylase activity
AN401_RS13855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN401_RS13860	COG1686	Belongs to the peptidase S11 family
AN401_RS13865	COG2921	Belongs to the UPF0250 family
AN401_RS13870	COG0321	lipoyl(octanoyl) transferase activity
AN401_RS13875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN401_RS13880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN401_RS13895	COG1671	Belongs to the UPF0178 family
AN401_RS13910	COG4232	protein-disulfide reductase activity
AN401_RS13915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AN401_RS13925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AN401_RS13930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AN401_RS13940	COG1073	alpha beta
AN401_RS13945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AN401_RS13950	COG0840	transmembrane signaling receptor activity
AN401_RS13955	COG2195	Cleaves the N-terminal amino acid of tripeptides
AN401_RS13965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AN401_RS13975	COG2991	Protein conserved in bacteria
AN401_RS13980	COG1477	protein flavinylation
AN401_RS13985	COG2871	sodium ion transport
AN401_RS13995	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN401_RS14000	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AN401_RS14005	COG1805	sodium ion transport
AN401_RS14015	COG0271	Belongs to the BolA IbaG family
AN401_RS14025	COG2813	Specifically methylates the guanine in position
AN401_RS14040	COG2211	Major facilitator Superfamily
AN401_RS14050	COG1666	GTP binding
AN401_RS14055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AN401_RS14060	COG0301	tRNA thio-modification
AN401_RS14060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_RS14065	COG1360	Flagellar Motor Protein
AN401_RS14070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN401_RS14080	COG0142	geranyltranstransferase activity
AN401_RS14085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AN401_RS14090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AN401_RS14110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_RS14125	COG0708	Exodeoxyribonuclease III
AN401_RS14135	COG4215	(ABC) transporter
AN401_RS14150	COG2431	L-lysine efflux transmembrane transporter activity
AN401_RS14155	COG2213	PTS system mannitol-specific
AN401_RS14155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_RS14160	COG0246	Mannitol dehydrogenase
AN401_RS14165	COG3722	fumarate hydratase activity
AN401_RS14170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AN401_RS14175	COG1944	ATP diphosphatase activity
AN401_RS14190	COG2358	TRAP transporter, solute receptor (TAXI family
AN401_RS14205	COG4191	Histidine kinase
AN401_RS14215	COG1959	2 iron, 2 sulfur cluster binding
AN401_RS14235	COG2198	Histidine kinase
AN401_RS14235	COG0784	Response regulator, receiver
AN401_RS14235	COG2205	protein histidine kinase activity
AN401_RS14240	COG2814	Major facilitator Superfamily
AN401_RS14255	COG5001	Diguanylate cyclase
AN401_RS14270	COG0584	glycerophosphoryl diester phosphodiesterase
AN401_RS14275	COG0583	DNA-binding transcription factor activity
AN401_RS14280	COG2828	Protein conserved in bacteria
AN401_RS14295	COG1049	propionate catabolic process, 2-methylcitrate cycle
AN401_RS14310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN401_RS14310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AN401_RS14325	COG1611	Belongs to the LOG family
AN401_RS14330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN401_RS14335	COG0473	3-isopropylmalate dehydrogenase activity
AN401_RS14345	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AN401_RS14350	COG2363	Small membrane protein
AN401_RS14360	COG0583	DNA-binding transcription factor activity
AN401_RS14385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN401_RS14435	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AN401_RS14460	COG0328	RNA-DNA hybrid ribonuclease activity
AN401_RS14465	COG2226	methyltransferase
AN401_RS14470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN401_RS14475	COG1388	LysM domain
AN401_RS14475	COG0741	lytic transglycosylase activity
AN401_RS14485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AN401_RS14490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN401_RS14500	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AN401_RS14505	COG0077	Prephenate dehydratase
AN401_RS14505	COG1605	Chorismate mutase
AN401_RS14510	COG0287	Prephenate dehydrogenase
AN401_RS14510	COG1605	Chorismate mutase
AN401_RS14515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN401_RS14530	COG1125	glycine betaine transport
AN401_RS14530	COG0517	IMP dehydrogenase activity
AN401_RS14535	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AN401_RS14540	COG0811	peptide transport
AN401_RS14545	COG0848	biopolymer transport protein
AN401_RS14580	COG0028	Belongs to the TPP enzyme family
AN401_RS14595	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS14610	COG2271	Major facilitator Superfamily
AN401_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS14650	COG1082	Xylose isomerase domain protein TIM barrel
AN401_RS14660	COG0488	(ABC) transporter
AN401_RS14675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN401_RS14690	COG0583	DNA-binding transcription factor activity
AN401_RS14695	COG2056	Na+-H+ antiporter family
AN401_RS14705	COG3314	Sporulation integral membrane protein YlbJ
AN401_RS14720	COG1960	acyl-CoA dehydrogenase activity
AN401_RS14735	COG0733	neurotransmitter:sodium symporter activity
AN401_RS14740	COG3844	kynureninase activity
AN401_RS14745	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AN401_RS14750	COG3483	tryptophan 2,3-dioxygenase activity
AN401_RS14765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AN401_RS14785	COG2207	Transcriptional regulator
AN401_RS14790	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS14790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS14800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS14845	COG0543	2 iron, 2 sulfur cluster binding
AN401_RS14845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_RS14850	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AN401_RS14855	COG4638	Rieske (2fe-2S)
AN401_RS14870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN401_RS14870	COG1017	nitric oxide dioxygenase activity
AN401_RS14875	COG2301	Belongs to the HpcH HpaI aldolase family
AN401_RS14895	COG1388	LysM domain
AN401_RS14895	COG0741	lytic transglycosylase activity
AN401_RS14905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AN401_RS14910	COG1191	sigma factor activity
AN401_RS14935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AN401_RS14940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AN401_RS14965	COG1706	bacterial-type flagellum-dependent cell motility
AN401_RS14970	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AN401_RS14975	COG4786	Flagellar basal body rod
AN401_RS14980	COG4787	bacterial-type flagellum-dependent cell motility
AN401_RS14985	COG1749	Flagellar hook protein flgE
AN401_RS15000	COG1815	bacterial-type flagellum-dependent cell motility
AN401_RS15045	COG1677	Flagellar hook-basal body complex protein FliE
AN401_RS15075	COG1987	bacterial-type flagellum assembly
AN401_RS15105	COG0651	ATP synthesis coupled electron transport
AN401_RS15110	COG0651	ATP synthesis coupled electron transport
AN401_RS15115	COG0651	ATP synthesis coupled electron transport
AN401_RS15120	COG1006	Multisubunit Na H antiporter MnhC subunit
AN401_RS15135	COG1320	monovalent cation:proton antiporter activity
AN401_RS15145	COG1863	multisubunit Na H antiporter MnhE subunit
AN401_RS15150	COG0789	Transcriptional regulator
AN401_RS15165	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS15175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AN401_RS15185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS15200	COG0138	bifunctional purine biosynthesis protein purh
AN401_RS15205	COG0151	Belongs to the GarS family
AN401_RS15220	COG0776	regulation of translation
AN401_RS15225	COG2084	Dehydrogenase
AN401_RS15235	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS15240	COG3138	arginine N-succinyltransferase
AN401_RS15245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN401_RS15265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN401_RS15270	COG2201	protein-glutamate methylesterase activity
AN401_RS15275	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AN401_RS15285	COG0840	transmembrane signaling receptor activity
AN401_RS15290	COG0835	chemotaxis
AN401_RS15300	COG0643	Histidine kinase
AN401_RS15300	COG2198	Histidine kinase
AN401_RS15310	COG0745	RESPONSE REGULATOR receiver
AN401_RS15315	COG0840	transmembrane signaling receptor activity
AN401_RS15325	COG3706	GGDEF domain
AN401_RS15325	COG4251	negative regulation of phosphorylation
AN401_RS15325	COG5001	Diguanylate cyclase
AN401_RS15325	COG2203	Gaf domain
AN401_RS15340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AN401_RS15350	COG2154	pterin-4-alpha-carbinolamine dehydratase
AN401_RS15360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_RS15365	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS15370	COG1917	Cupin 2, conserved barrel domain protein
AN401_RS15370	COG1396	sequence-specific DNA binding
AN401_RS15375	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN401_RS15380	COG0174	glutamine synthetase
AN401_RS15385	COG1757	Na H antiporter
AN401_RS15390	COG2897	thiosulfate sulfurtransferase activity
AN401_RS15395	COG2391	methyltransferase activity
AN401_RS15400	COG1294	oxidase, subunit
AN401_RS15405	COG1271	oxidase subunit
AN401_RS15410	COG4191	Histidine kinase
AN401_RS15415	COG2204	response regulator
AN401_RS15425	COG0733	neurotransmitter:sodium symporter activity
AN401_RS15435	COG1522	sequence-specific DNA binding
AN401_RS15440	COG4608	Belongs to the ABC transporter superfamily
AN401_RS15445	COG0444	Belongs to the ABC transporter superfamily
AN401_RS15450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN401_RS15455	COG0601	transmembrane transport
AN401_RS15460	COG0747	negative chemotaxis
AN401_RS15470	COG0402	S-adenosylhomocysteine deaminase activity
AN401_RS15485	COG0210	DNA helicase
AN401_RS15490	COG1522	sequence-specific DNA binding
AN401_RS15495	COG0531	amino acid
AN401_RS15510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AN401_RS15515	COG0583	DNA-binding transcription factor activity
AN401_RS15525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_RS15530	COG0433	COG0433 Predicted ATPase
AN401_RS15535	COG2193	ferroxidase activity
AN401_RS15545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN401_RS15550	COG1609	Transcriptional regulator
AN401_RS15555	COG2723	6-phospho-beta-galactosidase activity
AN401_RS15570	COG1132	(ABC) transporter
AN401_RS15605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN401_RS15625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AN401_RS15635	COG0625	glutathione transferase activity
AN401_RS15640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN401_RS15660	COG0546	phosphoglycolate phosphatase activity
AN401_RS15665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN401_RS15675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AN401_RS15685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AN401_RS15690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AN401_RS15720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AN401_RS15730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_RS15740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN401_RS15780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AN401_RS15785	COG3596	GTP binding
AN401_RS15790	COG0735	belongs to the Fur family
AN401_RS15800	COG0385	Bile acid
AN401_RS15805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN401_RS15810	COG0305	Participates in initiation and elongation during chromosome replication
AN401_RS15825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AN401_RS15830	COG5016	pyruvate
AN401_RS15830	COG0511	ligase activity, forming carbon-carbon bonds
AN401_RS15865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AN401_RS15875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AN401_RS15880	COG1546	Belongs to the CinA family
AN401_RS15885	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AN401_RS15895	COG4942	peptidase
AN401_RS15895	COG1388	LysM domain
AN401_RS15905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AN401_RS15910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AN401_RS15915	COG0585	pseudouridine synthase activity
AN401_RS15925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AN401_RS15930	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AN401_RS15940	COG0504	CTP synthase activity
AN401_RS15960	COG1028	Short-chain dehydrogenase reductase Sdr
AN401_RS15970	COG1024	Enoyl-CoA hydratase
AN401_RS15980	COG1960	acyl-CoA dehydrogenase activity
AN401_RS15995	COG1960	acyl-CoA dehydrogenase activity
AN401_RS16000	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN401_RS16020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS16025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS16030	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS16035	COG3265	gluconokinase activity
AN401_RS16045	COG0800	Aldolase
AN401_RS16050	COG1609	Transcriptional regulator
AN401_RS16055	COG0166	Belongs to the GPI family
AN401_RS16060	COG0039	L-malate dehydrogenase activity
AN401_RS16065	COG4160	amino acid transport
AN401_RS16070	COG4215	(ABC) transporter
AN401_RS16075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_RS16080	COG1126	abc transporter atp-binding protein
AN401_RS16085	COG1438	arginine binding
AN401_RS16095	COG2837	iron assimilation
AN401_RS16100	COG3842	ATPase activity
AN401_RS16110	COG1840	ABC-type Fe3 transport system, periplasmic component
AN401_RS16115	COG0004	ammonium transporteR
AN401_RS16125	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AN401_RS16135	COG1049	propionate catabolic process, 2-methylcitrate cycle
AN401_RS16150	COG0840	transmembrane signaling receptor activity
AN401_RS16155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN401_RS16160	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN401_RS16165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AN401_RS16180	COG3577	Aspartyl protease
AN401_RS16195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN401_RS16200	COG1459	type II secretion system
AN401_RS16215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN401_RS16220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_RS16225	COG1194	a g-specific adenine glycosylase
AN401_RS16230	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AN401_RS16260	COG1278	Cold shock
AN401_RS16275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN401_RS16280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN401_RS16285	COG2813	Specifically methylates the guanine in position
AN401_RS16320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AN401_RS16335	COG0795	lipopolysaccharide-transporting ATPase activity
AN401_RS16340	COG0795	lipopolysaccharide-transporting ATPase activity
AN401_RS16345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AN401_RS16350	COG2927	DNA polymerase III (CHI subunit)
AN401_RS16355	COG0525	valine-tRNA ligase activity
AN401_RS16365	COG3706	GGDEF domain
AN401_RS16370	COG2885	chlorophyll binding
AN401_RS16380	COG2169	Transcriptional regulator
AN401_RS16380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN401_RS16390	COG0252	asparaginase activity
AN401_RS16395	COG1027	Aspartate ammonia-lyase
AN401_RS16420	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AN401_RS16435	COG0653	protein targeting
AN401_RS16445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AN401_RS16450	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN401_RS16455	COG0849	cell division
AN401_RS16460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AN401_RS16465	COG1181	Belongs to the D-alanine--D-alanine ligase family
AN401_RS16470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN401_RS16475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AN401_RS16480	COG0772	Belongs to the SEDS family
AN401_RS16485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AN401_RS16490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AN401_RS16495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN401_RS16500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN401_RS16505	COG0768	penicillin binding
AN401_RS16510	COG3116	cell division
AN401_RS16515	COG0275	rRNA processing
AN401_RS16520	COG2001	Belongs to the MraZ family
AN401_RS16530	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AN401_RS16535	COG3107	peptidoglycan biosynthetic process
AN401_RS16540	COG0792	nuclease activity
AN401_RS16545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AN401_RS16550	COG2823	Periplasmic or secreted lipoprotein
AN401_RS16555	COG2969	positive regulation of protein catabolic process
AN401_RS16560	COG0625	glutathione transferase activity
AN401_RS16565	COG2857	Cytochrome c1
AN401_RS16570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AN401_RS16575	COG0723	plastoquinol--plastocyanin reductase activity
AN401_RS16580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN401_RS16585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AN401_RS16590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN401_RS16595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN401_RS16600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN401_RS16605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN401_RS16610	COG5007	Belongs to the BolA IbaG family
AN401_RS16620	COG2854	intermembrane phospholipid transfer
AN401_RS16625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN401_RS16630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN401_RS16635	COG1127	ABC transporter
AN401_RS16645	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AN401_RS16655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AN401_RS16660	COG1137	ATPase activity
AN401_RS16665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AN401_RS16675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_RS16680	COG1660	Displays ATPase and GTPase activities
AN401_RS16685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN401_RS16690	COG2239	Acts as a magnesium transporter
AN401_RS16695	COG0312	modulator of DNA gyrase
AN401_RS16700	COG3028	Belongs to the UPF0307 family
AN401_RS16710	COG0312	modulator of DNA gyrase
AN401_RS16715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_RS16725	COG1530	ribonuclease E activity
AN401_RS16730	COG0424	maF-like protein
AN401_RS16735	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AN401_RS16740	COG1792	Involved in formation and maintenance of cell shape
AN401_RS16745	COG1077	Cell shape determining protein MreB Mrl
AN401_RS16750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AN401_RS16755	COG2200	EAL domain
AN401_RS16755	COG2199	diguanylate cyclase activity
AN401_RS16765	COG2814	Major facilitator Superfamily
AN401_RS16770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AN401_RS16785	COG0390	transport system, permease component
AN401_RS16815	COG1127	ABC transporter
AN401_RS16820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN401_RS16830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN401_RS16835	COG1686	Belongs to the peptidase S11 family
AN401_RS16840	COG1410	methionine synthase
AN401_RS16840	COG0646	methionine synthase
AN401_RS16850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AN401_RS16855	COG1546	Belongs to the CinA family
AN401_RS16855	COG1058	Belongs to the CinA family
AN401_RS16870	COG2233	PERMEase
AN401_RS16895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AN401_RS16905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AN401_RS16910	COG0583	DNA-binding transcription factor activity
AN401_RS16915	COG0408	coproporphyrinogen oxidase activity
AN401_RS16920	COG0009	L-threonylcarbamoyladenylate synthase
AN401_RS16925	COG0551	DNA topoisomerase type I activity
AN401_RS16930	COG2922	Belongs to the Smg family
AN401_RS16935	COG0758	DNA mediated transformation
AN401_RS16940	COG1652	LysM domain
AN401_RS16945	COG0242	peptide deformylase activity
AN401_RS16950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AN401_RS16955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AN401_RS16955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AN401_RS16960	COG0569	domain protein
AN401_RS16965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN401_RS16970	COG1322	Protein conserved in bacteria
AN401_RS16990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AN401_RS16995	COG0840	transmembrane signaling receptor activity
AN401_RS17005	COG2501	S4 domain
AN401_RS17015	COG2258	MOSC domain
AN401_RS17025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AN401_RS17040	COG0435	Glutathione S-transferase
AN401_RS17045	COG1832	CoA-binding protein
AN401_RS17050	COG1757	Na H antiporter
AN401_RS17055	COG0174	glutamine synthetase
AN401_RS17060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN401_RS17070	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS17075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_RS17085	COG1917	Cupin 2, conserved barrel domain protein
AN401_RS17085	COG1396	sequence-specific DNA binding
AN401_RS17090	COG0003	Pfam Anion-transporting ATPase
AN401_RS17100	COG1966	Carbon starvation protein
AN401_RS17105	COG5001	Diguanylate cyclase
AN401_RS17105	COG2203	Gaf domain
AN401_RS17105	COG4251	negative regulation of phosphorylation
AN401_RS17105	COG3706	GGDEF domain
AN401_RS17130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS17135	COG0589	response to stress
AN401_RS17145	COG4191	Histidine kinase
AN401_RS17155	COG0584	glycerophosphoryl diester phosphodiesterase
AN401_RS17165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AN401_RS17170	COG3639	organic phosphonate transmembrane transporter activity
AN401_RS17175	COG3639	organic phosphonate transmembrane transporter activity
AN401_RS17205	COG0004	ammonium transporteR
AN401_RS17210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN401_RS17210	COG4191	Histidine kinase
AN401_RS17220	COG1301	dicarboxylic acid transport
AN401_RS17230	COG2200	EAL domain
AN401_RS17230	COG2199	diguanylate cyclase activity
AN401_RS17230	COG2202	Pas domain
AN401_RS17250	COG0745	RESPONSE REGULATOR receiver
AN401_RS17265	COG1335	isochorismatase
AN401_RS17295	COG0583	DNA-binding transcription factor activity
AN401_RS17310	COG4251	negative regulation of phosphorylation
AN401_RS17310	COG2203	Gaf domain
AN401_RS17310	COG3706	GGDEF domain
AN401_RS17310	COG5001	Diguanylate cyclase
AN401_RS17325	COG3177	Filamentation induced by cAMP protein fic
AN401_RS17345	COG1120	ATPase activity
AN401_RS17350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_RS17355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_RS17360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_RS17440	COG5433	transposase activity
AN401_RS17450	COG5433	transposase activity
AN401_RS17455	COG3604	Transcriptional regulator
AN401_RS17460	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AN401_RS17470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AN401_RS17475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN401_RS17480	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AN401_RS17490	COG0640	Transcriptional regulator
AN401_RS17495	COG0583	DNA-binding transcription factor activity
AN401_RS17500	COG4771	TonB-dependent receptor
AN401_RS17505	COG1960	acyl-CoA dehydrogenase activity
AN401_RS17510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_RS17515	COG0577	efflux transmembrane transporter activity
AN401_RS17515	COG1136	(ABC) transporter
AN401_RS17525	COG0076	glutamate decarboxylase activity
AN401_RS17530	COG3486	L-lysine 6-monooxygenase (NADPH) activity
AN401_RS17550	COG1120	ATPase activity
AN401_RS17555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_RS17560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN401_RS17565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AN401_RS17580	COG2193	ferroxidase activity
AN401_RS17590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN401_RS17595	COG0697	spore germination
AN401_RS17600	COG1451	nucleotide metabolic process
AN401_RS17605	COG2223	nitrite transmembrane transporter activity
AN401_RS17610	COG0515	serine threonine protein kinase
AN401_RS17615	COG0745	RESPONSE REGULATOR receiver
AN401_RS17620	COG2205	protein histidine kinase activity
AN401_RS17625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN401_RS17630	COG0569	domain protein
AN401_RS17635	COG0668	transmembrane transport
AN401_RS17640	COG0625	glutathione transferase activity
AN401_RS17645	COG0840	transmembrane signaling receptor activity
AN401_RS17650	COG0583	DNA-binding transcription factor activity
AN401_RS17655	COG0477	Major facilitator Superfamily
AN401_RS17660	COG1942	4-Oxalocrotonate Tautomerase
AN401_RS17665	COG4566	intracellular signal transduction
AN401_RS17670	COG4191	Histidine kinase
AN401_RS17675	COG0318	PFAM AMP-dependent synthetase and ligase
AN401_RS17685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN401_RS17695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN401_RS17725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AN401_RS17735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AN401_RS17735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AN401_RS17740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AN401_RS17745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN401_RS17750	COG0419	ATPase involved in DNA repair
AN401_RS17755	COG0420	3'-5' exonuclease activity
AN401_RS17765	COG0625	glutathione transferase activity
AN401_RS17780	COG0210	DNA helicase
AN401_RS17785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AN401_RS17790	COG2166	iron-sulfur cluster assembly
AN401_RS17795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AN401_RS17800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AN401_RS17805	COG0583	DNA-binding transcription factor activity
AN401_RS17810	COG2960	long-chain fatty acid transporting porin activity
AN401_RS17825	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AN401_RS17835	COG3118	belongs to the thioredoxin family
AN401_RS17840	COG0513	Belongs to the DEAD box helicase family
AN401_RS17845	COG0248	Ppx GppA phosphatase
AN401_RS17855	COG0084	hydrolase, TatD family'
AN401_RS17860	COG0805	protein transport
AN401_RS17865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN401_RS17870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AN401_RS17875	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AN401_RS17885	COG2226	methyltransferase
AN401_RS17890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AN401_RS17935	COG3901	Regulator of nitric oxide reductase transcription
AN401_RS17935	COG0348	domain, Protein
AN401_RS17940	COG0203	ribosomal protein L17
AN401_RS17945	COG0202	RNA polymerase activity
AN401_RS17950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AN401_RS17955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AN401_RS17960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AN401_RS17965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN401_RS17970	COG0201	protein transport
AN401_RS17980	COG1841	ribosomal large subunit assembly
AN401_RS17990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AN401_RS17995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AN401_RS18000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AN401_RS18005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AN401_RS18010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AN401_RS18015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AN401_RS18020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AN401_RS18030	COG0255	Belongs to the universal ribosomal protein uL29 family
AN401_RS18035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AN401_RS18040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AN401_RS18045	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AN401_RS18050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AN401_RS18055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AN401_RS18060	COG0089	rRNA binding
AN401_RS18065	COG0088	Forms part of the polypeptide exit tunnel
AN401_RS18070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AN401_RS18075	COG0051	transcription antitermination factor activity, RNA binding
AN401_RS18085	COG0137	argininosuccinate synthase activity
AN401_RS18095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AN401_RS18100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AN401_RS18110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AN401_RS18115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AN401_RS18125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AN401_RS18130	COG2261	transglycosylase associated protein
AN401_RS18140	COG2610	gluconate transmembrane transporter activity
AN401_RS18145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN401_RS18150	COG1349	DNA-binding transcription factor activity
AN401_RS18155	COG3622	Belongs to the hyi family
AN401_RS18160	COG0235	Class ii aldolase
AN401_RS18165	COG3395	kinase activity
AN401_RS18170	COG2084	Dehydrogenase
AN401_RS18175	COG0460	homoserine dehydrogenase
AN401_RS18175	COG0527	aspartate kinase activity
AN401_RS18180	COG0626	cystathionine gamma-synthase activity
AN401_RS18185	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AN401_RS18190	COG1218	3'(2'),5'-bisphosphate nucleotidase
AN401_RS18195	COG0494	nUDIX hydrolase
AN401_RS18205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AN401_RS18210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AN401_RS18215	COG1522	sequence-specific DNA binding
AN401_RS18225	COG0840	transmembrane signaling receptor activity
AN401_RS18240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN401_RS18250	COG1012	belongs to the aldehyde dehydrogenase family
AN401_RS18260	COG0626	cystathionine gamma-synthase activity
AN401_RS18265	COG0583	DNA-binding transcription factor activity
AN401_RS18270	COG2183	response to ionizing radiation
AN401_RS18285	COG2270	Major facilitator Superfamily
AN401_RS18290	COG0842	Transport permease protein
AN401_RS18295	COG1131	(ABC) transporter
AN401_RS18300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_RS18320	COG3021	interspecies interaction between organisms
AN401_RS18330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AN401_RS18340	COG0577	efflux transmembrane transporter activity
AN401_RS18340	COG1136	(ABC) transporter
AN401_RS18345	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AN401_RS18350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AN401_RS18355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AN401_RS18370	COG1053	succinate dehydrogenase
AN401_RS18370	COG0431	NADPH-dependent FMN reductase
AN401_RS18370	COG3976	FMN-binding domain protein
AN401_RS18395	COG1280	lysine exporter protein (LysE YggA)
AN401_RS18405	COG1011	Hydrolase
AN401_RS18410	COG3257	ureidoglycine aminohydrolase activity
AN401_RS18415	COG0583	DNA-binding transcription factor activity
AN401_RS18430	COG0765	amino acid transport
AN401_RS18435	COG0765	amino acid transport
AN401_RS18450	COG1953	Uracil, thiamine, allantoin
AN401_RS18465	COG0217	transcriptional regulatory protein
AN401_RS18480	COG0596	Alpha beta hydrolase
AN401_RS18485	COG1040	competence protein
AN401_RS18490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AN401_RS18490	COG0316	Belongs to the HesB IscA family
AN401_RS18495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AN401_RS18500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AN401_RS18505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AN401_RS18510	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AN401_RS18515	COG4942	peptidase
AN401_RS18525	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AN401_RS18540	COG1494	fructose-1,6-bisphosphatase
AN401_RS18545	COG0288	reversible hydration of carbon dioxide
AN401_RS18555	COG2177	Part of the ABC transporter FtsEX involved in
AN401_RS18560	COG2884	Cell division ATP-binding protein ftsE
AN401_RS18565	COG0552	protein localization to endoplasmic reticulum
AN401_RS18570	COG0742	ribosomal rna small subunit methyltransferase
AN401_RS18585	COG2897	thiosulfate sulfurtransferase activity
AN401_RS18605	COG0733	neurotransmitter:sodium symporter activity
AN401_RS18615	COG1770	oligopeptidase
AN401_RS18660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN401_RS18725	COG5265	(ABC) transporter
AN401_RS18735	COG0019	diaminopimelate decarboxylase activity
AN401_RS18745	COG1414	Transcriptional regulator
AN401_RS18750	COG0436	Aminotransferase
AN401_RS18755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN401_RS18785	COG1309	transcriptional regulator
AN401_RS18790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN401_RS18795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN401_RS18810	COG0006	proline dipeptidase activity
AN401_RS18815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN401_RS18820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AN401_RS18830	COG0456	acetyltransferase
AN401_RS18835	COG1490	D-aminoacyl-tRNA deacylase activity
AN401_RS18840	COG0596	Alpha beta hydrolase
AN401_RS18845	COG1295	ribonuclease BN
AN401_RS18850	COG1217	gtp-binding protein TYPA
AN401_RS18855	COG0174	glutamine synthetase
AN401_RS18865	COG1566	PFAM secretion protein HlyD family protein
AN401_RS18875	COG3852	Histidine kinase
AN401_RS18880	COG2204	response regulator
AN401_RS18895	COG0402	S-adenosylhomocysteine deaminase activity
AN401_RS18905	COG1609	Transcriptional regulator
AN401_RS18915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN401_RS18925	COG3078	GTPase activator activity
AN401_RS18940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AN401_RS18945	COG1187	pseudouridine synthase activity
AN401_RS18950	COG0745	RESPONSE REGULATOR receiver
AN401_RS18955	COG1320	monovalent cation:proton antiporter activity
AN401_RS18960	COG2212	antiporter activity
AN401_RS18965	COG1863	multisubunit Na H antiporter MnhE subunit
AN401_RS18970	COG0651	ATP synthesis coupled electron transport
AN401_RS18975	COG1006	Multisubunit Na H antiporter MnhC subunit
AN401_RS18980	COG2111	Na H antiporter
AN401_RS18985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN401_RS18985	COG2111	Na H antiporter
AN401_RS18990	COG0351	phosphomethylpyrimidine kinase
AN401_RS18995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN401_RS18995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN401_RS19000	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AN401_RS19005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AN401_RS19015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AN401_RS19025	COG0514	ATP-dependent DNA helicase (RecQ)
AN401_RS19050	COG0210	DNA helicase
AN401_RS19055	COG1011	Hydrolase
AN401_RS19060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN401_RS19070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AN401_RS19075	COG0019	diaminopimelate decarboxylase activity
AN401_RS19080	COG1965	Belongs to the frataxin family
AN401_RS19085	COG3072	Adenylate cyclase
AN401_RS19090	COG0181	hydroxymethylbilane synthase activity
AN401_RS19100	COG2959	enzyme of heme biosynthesis
AN401_RS19105	COG3071	HemY protein
AN401_RS19110	COG2084	Dehydrogenase
AN401_RS19135	COG0028	Belongs to the TPP enzyme family
AN401_RS19145	COG0606	chelatase, subunit chli
AN401_RS19155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN401_RS19160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AN401_RS19200	COG1253	flavin adenine dinucleotide binding
AN401_RS19205	COG1879	ABC-type sugar transport system periplasmic component
AN401_RS19215	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AN401_RS19220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN401_RS19225	COG1349	DNA-binding transcription factor activity
AN401_RS19230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AN401_RS19235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AN401_RS19240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AN401_RS19245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AN401_RS19250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AN401_RS19255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AN401_RS19260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AN401_RS19270	COG0356	it plays a direct role in the translocation of protons across the membrane
AN401_RS19280	COG1475	DNA binding
AN401_RS19285	COG1192	Involved in chromosome partitioning
AN401_RS19290	COG0357	Ribosomal RNA small subunit methyltransferase G
AN401_RS19295	COG0445	tRNA wobble uridine modification
AN401_RS19300	COG0716	FMN binding
AN401_RS19310	COG3409	Peptidoglycan-binding domain 1 protein
AN401_RS19310	COG3267	Type II secretory pathway component ExeA
AN401_RS19315	COG2204	response regulator
AN401_RS19340	COG1450	Type ii and iii secretion system protein
AN401_RS19355	COG3166	PFAM Fimbrial assembly family protein
AN401_RS19370	COG2165	general secretion pathway protein
AN401_RS19380	COG2165	general secretion pathway protein
AN401_RS19385	COG1459	type II secretion system
AN401_RS19390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AN401_RS19395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN401_RS19450	COG1139	Iron-sulfur cluster binding protein
AN401_RS19455	COG0247	lactate metabolic process
AN401_RS19460	COG1620	l-lactate permease
AN401_RS19465	COG0583	DNA-binding transcription factor activity
AN401_RS19470	COG0673	inositol 2-dehydrogenase activity
AN401_RS19475	COG2855	membrane
AN401_RS19480	COG0583	DNA-binding transcription factor activity
AN401_RS19485	COG1309	transcriptional regulator
AN401_RS19490	COG1902	pentaerythritol trinitrate reductase activity
AN401_RS19495	COG0840	transmembrane signaling receptor activity
AN401_RS19500	COG2326	polyphosphate kinase activity
AN401_RS19505	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AN401_RS19510	COG1522	sequence-specific DNA binding
AN401_RS19525	COG1280	lysine exporter protein (LysE YggA)
AN401_RS19540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AN401_RS19550	COG0732	type I restriction modification DNA specificity domain
AN401_RS19555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AN401_RS19565	COG0464	growth
AN401_RS19575	COG3550	peptidyl-serine autophosphorylation
AN401_RS19585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AN401_RS19590	COG0706	membrane insertase activity
AN401_RS19595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AN401_RS19600	COG0594	ribonuclease P activity
AN401_RS19605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN401_RS19610	COG1126	abc transporter atp-binding protein