locus-tag	class	description
ZPR_RS00015	COG0481	GTPase activity
ZPR_RS00020	COG0217	transcriptional regulatory protein
ZPR_RS00025	COG3263	regulation of cellular component size
ZPR_RS00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_RS00050	COG0594	ribonuclease P activity
ZPR_RS00055	COG0793	Belongs to the peptidase S41A family
ZPR_RS00060	COG2153	protein acetylation
ZPR_RS00065	COG0698	ribose 5-phosphate isomerase
ZPR_RS00075	COG0557	exoribonuclease II activity
ZPR_RS00105	COG0531	amino acid
ZPR_RS00110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZPR_RS00130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZPR_RS00140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZPR_RS00145	COG0445	tRNA wobble uridine modification
ZPR_RS00170	COG0470	DNA polymerase III
ZPR_RS00175	COG0126	phosphoglycerate kinase activity
ZPR_RS00180	COG1388	LysM domain
ZPR_RS00180	COG3942	CHAP domain
ZPR_RS00190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZPR_RS00210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_RS00215	COG1215	transferase activity, transferring glycosyl groups
ZPR_RS00225	COG0151	Belongs to the GarS family
ZPR_RS00250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ZPR_RS00300	COG0356	it plays a direct role in the translocation of protons across the membrane
ZPR_RS00305	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZPR_RS00310	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZPR_RS00320	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZPR_RS00325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZPR_RS00340	COG0756	dUTP diphosphatase activity
ZPR_RS00375	COG1607	acyl-coa hydrolase
ZPR_RS00385	COG0758	DNA mediated transformation
ZPR_RS00385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZPR_RS00390	COG0180	Tryptophanyl-tRNA synthetase
ZPR_RS00425	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZPR_RS00430	COG0826	peptidase U32
ZPR_RS00440	COG1054	Belongs to the UPF0176 family
ZPR_RS00445	COG1774	PSP1 C-terminal conserved region
ZPR_RS00455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZPR_RS00460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ZPR_RS00480	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_RS00480	COG1506	peptidase
ZPR_RS00495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZPR_RS00515	COG0113	porphobilinogen synthase activity
ZPR_RS00525	COG0408	coproporphyrinogen oxidase activity
ZPR_RS00540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZPR_RS00550	COG0181	hydroxymethylbilane synthase activity
ZPR_RS00555	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ZPR_RS00570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZPR_RS00580	COG1981	membrane
ZPR_RS00590	COG1024	Enoyl-CoA hydratase
ZPR_RS00620	COG1418	mRNA catabolic process
ZPR_RS00635	COG0484	heat shock protein binding
ZPR_RS00650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_RS00660	COG0720	synthase
ZPR_RS00675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZPR_RS00685	COG0352	thiamine-phosphate diphosphorylase activity
ZPR_RS00690	COG2022	thiamine diphosphate biosynthetic process
ZPR_RS00695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZPR_RS00705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZPR_RS00710	COG0024	Methionine aminopeptidase
ZPR_RS00715	COG1621	beta-fructofuranosidase activity
ZPR_RS00765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ZPR_RS00770	COG1335	isochorismatase
ZPR_RS00790	COG1381	Involved in DNA repair and RecF pathway recombination
ZPR_RS00860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZPR_RS00875	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZPR_RS00880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ZPR_RS00890	COG0189	ligase activity
ZPR_RS00900	COG0322	excinuclease ABC activity
ZPR_RS00905	COG1752	Esterase of the alpha-beta hydrolase superfamily
ZPR_RS00915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZPR_RS00920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ZPR_RS00925	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ZPR_RS00935	COG3483	tryptophan 2,3-dioxygenase activity
ZPR_RS00945	COG0166	Belongs to the GPI family
ZPR_RS00950	COG4771	TonB-dependent receptor
ZPR_RS00960	COG2356	endonuclease I
ZPR_RS01000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZPR_RS01015	COG2151	metal-sulfur cluster biosynthetic enzyme
ZPR_RS01020	COG2166	iron-sulfur cluster assembly
ZPR_RS01030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZPR_RS01035	COG0719	Fe-S assembly protein
ZPR_RS01040	COG0396	ATPase activity
ZPR_RS01050	COG0719	Fe-S assembly protein
ZPR_RS01060	COG0316	Belongs to the HesB IscA family
ZPR_RS01065	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZPR_RS01085	COG0702	epimerase
ZPR_RS01090	COG1629	transport
ZPR_RS01110	COG0006	proline dipeptidase activity
ZPR_RS01115	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS01120	COG0367	asparagine synthase
ZPR_RS01130	COG1053	succinate dehydrogenase
ZPR_RS01135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ZPR_RS01155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZPR_RS01155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZPR_RS01175	COG1321	iron dependent repressor
ZPR_RS01175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZPR_RS01205	COG1999	signal sequence binding
ZPR_RS01210	COG0750	zinc metalloprotease
ZPR_RS01215	COG0584	glycerophosphoryl diester phosphodiesterase
ZPR_RS01230	COG4206	TonB-dependent receptor
ZPR_RS01230	COG1629	transport
ZPR_RS01265	COG0534	Mate efflux family protein
ZPR_RS01300	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_RS01305	COG1074	ATP-dependent DNA helicase activity
ZPR_RS01315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZPR_RS01325	COG0328	RNA-DNA hybrid ribonuclease activity
ZPR_RS01335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZPR_RS01340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZPR_RS01345	COG0571	ribonuclease III activity
ZPR_RS01355	COG0469	pyruvate kinase activity
ZPR_RS01360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZPR_RS01365	COG0702	epimerase
ZPR_RS01370	COG2954	triphosphatase activity
ZPR_RS01385	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ZPR_RS01395	COG1538	Outer membrane efflux protein
ZPR_RS01405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS01420	COG1446	asparaginase
ZPR_RS01425	COG0662	Cupin 2, conserved barrel domain protein
ZPR_RS01435	COG0653	protein targeting
ZPR_RS01450	COG3279	Response regulator of the LytR AlgR family
ZPR_RS01465	COG2824	Alkylphosphonate utilization operon protein PhnA
ZPR_RS01470	COG0793	Belongs to the peptidase S41A family
ZPR_RS01475	COG3339	Conserved Protein
ZPR_RS01495	COG4221	oxidoreductase activity
ZPR_RS01505	COG0714	Associated with various cellular activities
ZPR_RS01520	COG2304	oxidoreductase activity
ZPR_RS01545	COG0288	reversible hydration of carbon dioxide
ZPR_RS01570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZPR_RS01590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZPR_RS01595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZPR_RS01600	COG0194	GDP metabolic process
ZPR_RS01605	COG1561	YicC-like family, N-terminal region
ZPR_RS01610	COG0429	hydrolase of the alpha beta-hydrolase fold
ZPR_RS01635	COG0626	cystathionine gamma-synthase activity
ZPR_RS01650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZPR_RS01690	COG4771	TonB-dependent receptor
ZPR_RS01695	COG0702	epimerase
ZPR_RS01705	COG4124	Belongs to the glycosyl hydrolase 26 family
ZPR_RS01720	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ZPR_RS01725	COG2942	2-epimerase
ZPR_RS01730	COG2272	Belongs to the type-B carboxylesterase lipase family
ZPR_RS01740	COG2382	esterase
ZPR_RS01740	COG3693	PFAM glycoside hydrolase, family 10
ZPR_RS01750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZPR_RS01760	COG0471	metal ion transport
ZPR_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS01830	COG1595	DNA-templated transcription, initiation
ZPR_RS01840	COG4771	TonB-dependent receptor
ZPR_RS01850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS01865	COG0612	Peptidase, M16
ZPR_RS01880	COG4771	TonB-dependent receptor
ZPR_RS01915	COG3720	iron ion transport
ZPR_RS01920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZPR_RS01925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZPR_RS01935	COG4206	TonB-dependent receptor
ZPR_RS01980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZPR_RS01990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZPR_RS02000	COG2095	MarC family integral membrane protein
ZPR_RS02020	COG0793	Belongs to the peptidase S41A family
ZPR_RS02045	COG4585	Histidine kinase
ZPR_RS02050	COG2197	response regulator
ZPR_RS02125	COG4771	TonB-dependent receptor
ZPR_RS02140	COG0477	Major facilitator Superfamily
ZPR_RS02150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZPR_RS02155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZPR_RS02160	COG0193	aminoacyl-tRNA hydrolase activity
ZPR_RS02165	COG0196	riboflavin kinase activity
ZPR_RS02175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZPR_RS02195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZPR_RS02200	COG2239	Acts as a magnesium transporter
ZPR_RS02205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_RS02215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZPR_RS02220	COG0702	epimerase
ZPR_RS02230	COG0527	aspartate kinase activity
ZPR_RS02245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ZPR_RS02260	COG1793	dna ligase
ZPR_RS02270	COG1201	RNA secondary structure unwinding
ZPR_RS02280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZPR_RS02300	COG0423	glycine-tRNA ligase activity
ZPR_RS02305	COG1528	Iron-storage protein
ZPR_RS02310	COG1522	sequence-specific DNA binding
ZPR_RS02320	COG2363	Small membrane protein
ZPR_RS02325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZPR_RS02340	COG0463	Glycosyl transferase, family 2
ZPR_RS02345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZPR_RS02360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZPR_RS02380	COG4771	TonB-dependent receptor
ZPR_RS02385	COG0745	RESPONSE REGULATOR receiver
ZPR_RS02390	COG5002	protein histidine kinase activity
ZPR_RS02400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZPR_RS02415	COG0489	protein tyrosine kinase activity
ZPR_RS02425	COG0492	ferredoxin-NADP+ reductase activity
ZPR_RS02440	COG1960	acyl-CoA dehydrogenase activity
ZPR_RS02445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ZPR_RS02450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZPR_RS02455	COG0052	Belongs to the universal ribosomal protein uS2 family
ZPR_RS02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZPR_RS02465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZPR_RS02470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZPR_RS02470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZPR_RS02480	COG1446	asparaginase
ZPR_RS02515	COG0471	metal ion transport
ZPR_RS02515	COG3273	potassium ion transport
ZPR_RS02525	COG4771	TonB-dependent receptor
ZPR_RS02535	COG0612	Peptidase, M16
ZPR_RS02580	COG0662	Cupin 2, conserved barrel domain protein
ZPR_RS02580	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ZPR_RS02585	COG0529	Catalyzes the synthesis of activated sulfate
ZPR_RS02590	COG0175	sulfate reduction
ZPR_RS02600	COG1218	3'(2'),5'-bisphosphate nucleotidase
ZPR_RS02605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZPR_RS02610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_RS02615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ZPR_RS02655	COG0438	transferase activity, transferring glycosyl groups
ZPR_RS02670	COG0438	transferase activity, transferring glycosyl groups
ZPR_RS02690	COG0463	Glycosyl transferase, family 2
ZPR_RS02715	COG3206	protein involved in exopolysaccharide biosynthesis
ZPR_RS02715	COG0489	protein tyrosine kinase activity
ZPR_RS02745	COG0779	Required for maturation of 30S ribosomal subunits
ZPR_RS02750	COG2251	uridine kinase activity
ZPR_RS02750	COG0195	Participates in both transcription termination and antitermination
ZPR_RS02755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZPR_RS02765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ZPR_RS02765	COG2010	Cytochrome c
ZPR_RS02770	COG0437	4 iron, 4 sulfur cluster binding
ZPR_RS02800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ZPR_RS02805	COG2255	four-way junction helicase activity
ZPR_RS02810	COG2124	cytochrome p450
ZPR_RS02815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZPR_RS02820	COG0281	malic enzyme
ZPR_RS02820	COG0280	phosphate acetyltransferase
ZPR_RS02825	COG0632	four-way junction helicase activity
ZPR_RS02835	COG0509	glycine decarboxylation via glycine cleavage system
ZPR_RS02855	COG0109	protoheme IX farnesyltransferase activity
ZPR_RS02860	COG1845	cytochrome c oxidase, subunit III
ZPR_RS02865	COG1845	cytochrome c oxidase, subunit III
ZPR_RS02880	COG1999	signal sequence binding
ZPR_RS02885	COG2322	membrane
ZPR_RS02895	COG1136	(ABC) transporter
ZPR_RS02900	COG1136	(ABC) transporter
ZPR_RS02900	COG0577	efflux transmembrane transporter activity
ZPR_RS02905	COG1136	(ABC) transporter
ZPR_RS02905	COG0577	efflux transmembrane transporter activity
ZPR_RS02910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS02925	COG1214	PFAM Peptidase M22, glycoprotease
ZPR_RS02930	COG0668	transmembrane transport
ZPR_RS02935	COG1331	Highly conserved protein containing a thioredoxin domain
ZPR_RS02955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZPR_RS02970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZPR_RS02985	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZPR_RS02995	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZPR_RS03000	COG0596	Alpha beta hydrolase
ZPR_RS03015	COG1950	PFAM Membrane protein of
ZPR_RS03020	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZPR_RS03030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZPR_RS03040	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_RS03040	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_RS03045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS03050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZPR_RS03055	COG0587	DNA-directed DNA polymerase activity
ZPR_RS03065	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZPR_RS03075	COG0457	Tetratricopeptide repeat
ZPR_RS03090	COG1253	flavin adenine dinucleotide binding
ZPR_RS03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZPR_RS03110	COG1506	peptidase
ZPR_RS03110	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_RS03115	COG3104	oligopeptide transport
ZPR_RS03125	COG0658	competence protein
ZPR_RS03125	COG2333	competence protein COMEC
ZPR_RS03140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_RS03150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZPR_RS03165	COG0772	Belongs to the SEDS family
ZPR_RS03170	COG0768	penicillin binding
ZPR_RS03185	COG1077	Cell shape determining protein MreB Mrl
ZPR_RS03190	COG0138	bifunctional purine biosynthesis protein purh
ZPR_RS03220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_RS03240	COG4977	sequence-specific DNA binding
ZPR_RS03240	COG1917	Cupin 2, conserved barrel domain protein
ZPR_RS03250	COG2217	Heavy metal translocating P-type atpase
ZPR_RS03255	COG0701	Predicted permease
ZPR_RS03270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ZPR_RS03275	COG0401	homolog of Blt101
ZPR_RS03280	COG0321	lipoyl(octanoyl) transferase activity
ZPR_RS03285	COG4771	TonB-dependent receptor
ZPR_RS03295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZPR_RS03300	COG4771	TonB-dependent receptor
ZPR_RS03310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZPR_RS03315	COG4771	TonB-dependent receptor
ZPR_RS03325	COG4771	TonB-dependent receptor
ZPR_RS03330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZPR_RS03380	COG1629	transport
ZPR_RS03405	COG2337	Toxic component of a toxin-antitoxin (TA) module
ZPR_RS03445	COG0702	epimerase
ZPR_RS03450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZPR_RS03510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZPR_RS03535	COG4115	mRNA cleavage
ZPR_RS03565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZPR_RS03585	COG0456	acetyltransferase
ZPR_RS03590	COG1846	Transcriptional regulator
ZPR_RS03595	COG4771	TonB-dependent receptor
ZPR_RS03605	COG4771	TonB-dependent receptor
ZPR_RS03610	COG0702	epimerase
ZPR_RS03630	COG0745	RESPONSE REGULATOR receiver
ZPR_RS03630	COG2205	protein histidine kinase activity
ZPR_RS03630	COG4191	Histidine kinase
ZPR_RS03650	COG0798	PFAM Bile acid sodium symporter
ZPR_RS03675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ZPR_RS03680	COG1349	DNA-binding transcription factor activity
ZPR_RS03685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ZPR_RS03695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ZPR_RS03710	COG0386	Belongs to the glutathione peroxidase family
ZPR_RS03715	COG1846	Transcriptional regulator
ZPR_RS03740	COG0659	secondary active sulfate transmembrane transporter activity
ZPR_RS03745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZPR_RS03755	COG1160	GTP binding
ZPR_RS03785	COG0739	heme binding
ZPR_RS03790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZPR_RS03805	COG3186	Phenylalanine-4-hydroxylase
ZPR_RS03815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ZPR_RS03825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ZPR_RS03835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ZPR_RS03850	COG0110	maltose O-acetyltransferase activity
ZPR_RS03870	COG0688	phosphatidylethanolamine metabolic process
ZPR_RS03875	COG4589	Belongs to the CDS family
ZPR_RS03885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZPR_RS03890	COG0799	negative regulation of ribosome biogenesis
ZPR_RS03895	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ZPR_RS03895	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ZPR_RS03905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZPR_RS03910	COG1051	belongs to the nudix hydrolase family
ZPR_RS03930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZPR_RS03940	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZPR_RS03950	COG0564	pseudouridine synthase activity
ZPR_RS03960	COG3022	response to hydroperoxide
ZPR_RS03975	COG0159	tryptophan synthase activity
ZPR_RS03980	COG0133	tryptophan synthase activity
ZPR_RS03985	COG0135	phosphoribosylanthranilate isomerase activity
ZPR_RS03990	COG0134	indole-3-glycerol-phosphate synthase activity
ZPR_RS03995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZPR_RS04000	COG0512	Glutamine amidotransferase of anthranilate synthase
ZPR_RS04000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZPR_RS04005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZPR_RS04010	COG2353	YceI-like domain
ZPR_RS04015	COG0778	Nitroreductase
ZPR_RS04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZPR_RS04035	COG2884	Cell division ATP-binding protein ftsE
ZPR_RS04060	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ZPR_RS04065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZPR_RS04070	COG0450	alkyl hydroperoxide reductase
ZPR_RS04080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZPR_RS04085	COG0569	domain protein
ZPR_RS04090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZPR_RS04105	COG1132	(ABC) transporter
ZPR_RS04115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZPR_RS04125	COG1862	Preprotein translocase
ZPR_RS04135	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZPR_RS04140	COG0167	dihydroorotate dehydrogenase activity
ZPR_RS04160	COG0516	GMP reductase activity
ZPR_RS04160	COG0517	IMP dehydrogenase activity
ZPR_RS04175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZPR_RS04180	COG0714	Associated with various cellular activities
ZPR_RS04185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZPR_RS04195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS04215	COG1233	COG1233 Phytoene dehydrogenase and related
ZPR_RS04270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZPR_RS04275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ZPR_RS04280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ZPR_RS04295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZPR_RS04300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ZPR_RS04305	COG0343	queuine tRNA-ribosyltransferase activity
ZPR_RS04315	COG0825	malonyl-CoA metabolic process
ZPR_RS04320	COG0305	Participates in initiation and elongation during chromosome replication
ZPR_RS04330	COG0432	Pfam Uncharacterised protein family UPF0047
ZPR_RS04340	COG4677	pectinesterase activity
ZPR_RS04345	COG3292	Two component regulator propeller
ZPR_RS04345	COG2205	protein histidine kinase activity
ZPR_RS04345	COG0745	RESPONSE REGULATOR receiver
ZPR_RS04360	COG1629	transport
ZPR_RS04365	COG0702	epimerase
ZPR_RS04375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ZPR_RS04380	COG3250	beta-galactosidase activity
ZPR_RS04420	COG2814	Major facilitator Superfamily
ZPR_RS04435	COG0492	ferredoxin-NADP+ reductase activity
ZPR_RS04440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZPR_RS04445	COG0095	Lipoate-protein ligase
ZPR_RS04455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZPR_RS04460	COG1185	polyribonucleotide nucleotidyltransferase activity
ZPR_RS04465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZPR_RS04470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZPR_RS04475	COG0191	fructose-bisphosphate aldolase activity
ZPR_RS04485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZPR_RS04495	COG2226	methyltransferase
ZPR_RS04500	COG0569	domain protein
ZPR_RS04505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZPR_RS04510	COG0436	Aminotransferase
ZPR_RS04515	COG3239	Fatty acid desaturase
ZPR_RS04520	COG0357	Ribosomal RNA small subunit methyltransferase G
ZPR_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_RS04555	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_RS04560	COG1805	sodium ion transport
ZPR_RS04570	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_RS04575	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ZPR_RS04590	COG1477	protein flavinylation
ZPR_RS04595	COG2226	methyltransferase
ZPR_RS04620	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ZPR_RS04635	COG0740	serine-type endopeptidase activity
ZPR_RS04655	COG5002	protein histidine kinase activity
ZPR_RS04660	COG0745	RESPONSE REGULATOR receiver
ZPR_RS04680	COG0101	tRNA pseudouridine synthase activity
ZPR_RS04685	COG1132	(ABC) transporter
ZPR_RS04700	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ZPR_RS04705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZPR_RS04720	COG0149	triose-phosphate isomerase activity
ZPR_RS04725	COG2264	protein methyltransferase activity
ZPR_RS04745	COG0629	single-stranded DNA binding
ZPR_RS04765	COG2197	response regulator
ZPR_RS04815	COG3250	beta-galactosidase activity
ZPR_RS04835	COG4145	pantothenate transmembrane transporter activity
ZPR_RS04845	COG2186	Transcriptional regulator
ZPR_RS04855	COG4771	TonB-dependent receptor
ZPR_RS04875	COG4771	TonB-dependent receptor
ZPR_RS04880	COG0702	epimerase
ZPR_RS04890	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS04895	COG2382	esterase
ZPR_RS04900	COG3693	PFAM glycoside hydrolase, family 10
ZPR_RS04900	COG2382	esterase
ZPR_RS04905	COG2382	esterase
ZPR_RS04915	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_RS04925	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_RS04930	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_RS04940	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_RS04985	COG2354	Protein conserved in bacteria
ZPR_RS04995	COG0745	RESPONSE REGULATOR receiver
ZPR_RS05035	COG2318	DinB family
ZPR_RS05050	COG0584	glycerophosphoryl diester phosphodiesterase
ZPR_RS05055	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ZPR_RS05065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ZPR_RS05080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZPR_RS05085	COG1917	Cupin 2, conserved barrel domain protein
ZPR_RS05085	COG2169	Transcriptional regulator
ZPR_RS05110	COG2267	carboxylic ester hydrolase activity
ZPR_RS05120	COG3952	Lipid A Biosynthesis
ZPR_RS05120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_RS05130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_RS05135	COG1703	isobutyryl-CoA mutase activity
ZPR_RS05140	COG1764	response to oxidative stress
ZPR_RS05175	COG0653	protein targeting
ZPR_RS05190	COG1136	(ABC) transporter
ZPR_RS05195	COG0463	Glycosyl transferase, family 2
ZPR_RS05210	COG0488	(ABC) transporter
ZPR_RS05265	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ZPR_RS05275	COG1215	transferase activity, transferring glycosyl groups
ZPR_RS05325	COG0367	asparagine synthase
ZPR_RS05330	COG1083	cytidylyl-transferase
ZPR_RS05335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZPR_RS05350	COG2089	acid synthase
ZPR_RS05355	COG1216	Glycosyl transferase, family 2
ZPR_RS05365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZPR_RS05385	COG0438	transferase activity, transferring glycosyl groups
ZPR_RS05395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ZPR_RS05400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZPR_RS05415	COG1137	ATPase activity
ZPR_RS05425	COG0805	protein transport
ZPR_RS05430	COG0517	IMP dehydrogenase activity
ZPR_RS05430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZPR_RS05435	COG0514	ATP-dependent DNA helicase (RecQ)
ZPR_RS05465	COG3876	Protein conserved in bacteria
ZPR_RS05470	COG0577	efflux transmembrane transporter activity
ZPR_RS05485	COG1115	amino acid carrier protein
ZPR_RS05515	COG1115	amino acid carrier protein
ZPR_RS05525	COG1960	acyl-CoA dehydrogenase activity
ZPR_RS05530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZPR_RS05535	COG4974	Belongs to the 'phage' integrase family
ZPR_RS05565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZPR_RS05585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZPR_RS05590	COG0081	regulation of translation
ZPR_RS05595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZPR_RS05600	COG0222	ribosome binding
ZPR_RS05605	COG0085	RNA polymerase activity
ZPR_RS05610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZPR_RS05625	COG1115	amino acid carrier protein
ZPR_RS05630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZPR_RS05635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ZPR_RS05655	COG0579	oxidoreductase
ZPR_RS05670	COG0561	phosphatase activity
ZPR_RS05675	COG1073	alpha beta
ZPR_RS05705	COG2205	protein histidine kinase activity
ZPR_RS05705	COG0784	Response regulator, receiver
ZPR_RS05715	COG0326	Molecular chaperone. Has ATPase activity
ZPR_RS05730	COG1506	peptidase
ZPR_RS05735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZPR_RS05740	COG3385	transposase activity
ZPR_RS05800	COG1473	amidohydrolase
ZPR_RS05810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ZPR_RS05820	COG0009	L-threonylcarbamoyladenylate synthase
ZPR_RS05825	COG0542	response to heat
ZPR_RS05845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZPR_RS05875	COG0300	oxidoreductase activity
ZPR_RS05880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ZPR_RS05890	COG0488	(ABC) transporter
ZPR_RS05910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZPR_RS05915	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_RS05920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZPR_RS05940	COG1546	Belongs to the CinA family
ZPR_RS05940	COG1058	Belongs to the CinA family
ZPR_RS05945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZPR_RS05950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZPR_RS05955	COG0552	protein localization to endoplasmic reticulum
ZPR_RS05960	COG0154	amidase activity
ZPR_RS06000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZPR_RS06035	COG0656	L-ascorbic acid biosynthetic process
ZPR_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_RS06050	COG4974	Belongs to the 'phage' integrase family
ZPR_RS06140	COG0612	Peptidase, M16
ZPR_RS06145	COG0702	epimerase
ZPR_RS06150	COG4771	TonB-dependent receptor
ZPR_RS06170	COG4974	Belongs to the 'phage' integrase family
ZPR_RS06200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ZPR_RS06265	COG0517	IMP dehydrogenase activity
ZPR_RS06270	COG4584	PFAM Integrase catalytic
ZPR_RS06275	COG1484	DNA-dependent DNA replication
ZPR_RS06425	COG1917	Cupin 2, conserved barrel domain protein
ZPR_RS06425	COG4977	sequence-specific DNA binding
ZPR_RS06430	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS06455	COG0490	domain, Protein
ZPR_RS06455	COG2985	domain, Protein
ZPR_RS06470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ZPR_RS06485	COG1053	succinate dehydrogenase
ZPR_RS06490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ZPR_RS06500	COG4221	oxidoreductase activity
ZPR_RS06505	COG0569	domain protein
ZPR_RS06510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZPR_RS06530	COG2205	protein histidine kinase activity
ZPR_RS06535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZPR_RS06540	COG0666	response to abiotic stimulus
ZPR_RS06545	COG3047	cAMP biosynthetic process
ZPR_RS06570	COG3534	alpha-L-arabinofuranosidase
ZPR_RS06585	COG1506	peptidase
ZPR_RS06585	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_RS06590	COG0561	phosphatase activity
ZPR_RS06595	COG1629	transport
ZPR_RS06600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZPR_RS06605	COG3938	Belongs to the proline racemase family
ZPR_RS06615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZPR_RS06620	COG2207	Transcriptional regulator
ZPR_RS06630	COG3250	beta-galactosidase activity
ZPR_RS06635	COG0006	proline dipeptidase activity
ZPR_RS06655	COG2311	Membrane
ZPR_RS06690	COG2010	Cytochrome c
ZPR_RS06690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ZPR_RS06695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ZPR_RS06700	COG1845	cytochrome c oxidase, subunit III
ZPR_RS06720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZPR_RS06725	COG0069	glutamate synthase activity
ZPR_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS06880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ZPR_RS06895	COG3609	addiction module antidote protein, CC2985 family
ZPR_RS06930	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_RS06940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZPR_RS06950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZPR_RS06975	COG0681	Belongs to the peptidase S26 family
ZPR_RS06980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZPR_RS06990	COG1475	DNA binding
ZPR_RS06995	COG1192	Involved in chromosome partitioning
ZPR_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS07005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_RS07005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_RS07010	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_RS07020	COG0572	uridine kinase
ZPR_RS07025	COG2010	Cytochrome c
ZPR_RS07030	COG2133	pyrroloquinoline quinone binding
ZPR_RS07055	COG5002	protein histidine kinase activity
ZPR_RS07065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZPR_RS07105	COG3239	Fatty acid desaturase
ZPR_RS07115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZPR_RS07235	COG2801	Transposase and inactivated derivatives
ZPR_RS07310	COG3250	beta-galactosidase activity
ZPR_RS07315	COG3250	beta-galactosidase activity
ZPR_RS07325	COG0657	acetylesterase activity
ZPR_RS07325	COG2755	lipolytic protein G-D-S-L family
ZPR_RS07335	COG4771	TonB-dependent receptor
ZPR_RS07340	COG1609	Transcriptional regulator
ZPR_RS07345	COG3347	Dehydrogenase
ZPR_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS07350	COG4952	isomerase
ZPR_RS07360	COG1304	FMN binding
ZPR_RS07370	COG4771	TonB-dependent receptor
ZPR_RS07375	COG0702	epimerase
ZPR_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS07425	COG1673	EVE domain
ZPR_RS07430	COG1846	Transcriptional regulator
ZPR_RS07450	COG4771	TonB-dependent receptor
ZPR_RS07505	COG1858	cytochrome C peroxidase
ZPR_RS07535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS07540	COG1309	transcriptional regulator
ZPR_RS07545	COG0386	Belongs to the glutathione peroxidase family
ZPR_RS07610	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS07615	COG3119	arylsulfatase activity
ZPR_RS07625	COG4771	TonB-dependent receptor
ZPR_RS07655	COG3851	Histidine kinase
ZPR_RS07690	COG1629	transport
ZPR_RS07720	COG4771	TonB-dependent receptor
ZPR_RS07770	COG0494	nUDIX hydrolase
ZPR_RS07780	COG0516	GMP reductase activity
ZPR_RS07790	COG0019	diaminopimelate decarboxylase activity
ZPR_RS07795	COG2814	Major facilitator Superfamily
ZPR_RS07800	COG0045	succinate-CoA ligase (ADP-forming) activity
ZPR_RS07810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ZPR_RS07845	COG1228	amidohydrolase
ZPR_RS07855	COG1064	alcohol dehydrogenase
ZPR_RS07860	COG0028	Belongs to the TPP enzyme family
ZPR_RS07865	COG0626	cystathionine gamma-synthase activity
ZPR_RS07870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ZPR_RS07890	COG3956	TIGRFAM MazG family protein
ZPR_RS07895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZPR_RS07905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZPR_RS07925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZPR_RS07945	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZPR_RS07955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ZPR_RS07960	COG0501	Belongs to the peptidase M48B family
ZPR_RS07965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZPR_RS07975	COG1228	amidohydrolase
ZPR_RS07990	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZPR_RS08000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZPR_RS08010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ZPR_RS08020	COG0105	UTP biosynthetic process
ZPR_RS08030	COG0066	3-isopropylmalate dehydratase activity
ZPR_RS08035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZPR_RS08040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZPR_RS08060	COG0564	pseudouridine synthase activity
ZPR_RS08070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ZPR_RS08095	COG1760	l-serine dehydratase
ZPR_RS08100	COG0443	Heat shock 70 kDa protein
ZPR_RS08130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ZPR_RS08145	COG2996	Protein conserved in bacteria
ZPR_RS08195	COG0022	dehydrogenase e1 component
ZPR_RS08205	COG1611	Belongs to the LOG family
ZPR_RS08210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZPR_RS08220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZPR_RS08245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS08260	COG1994	Peptidase M50
ZPR_RS08280	COG1921	L-seryl-tRNASec selenium transferase activity
ZPR_RS08285	COG0251	oxidation-reduction process
ZPR_RS08295	COG1629	transport
ZPR_RS08315	COG0604	alcohol dehydrogenase
ZPR_RS08320	COG1475	DNA binding
ZPR_RS08335	COG0629	single-stranded DNA binding
ZPR_RS08370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_RS08425	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZPR_RS08425	COG1388	LysM domain
ZPR_RS08465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZPR_RS08515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZPR_RS08515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_RS08525	COG0450	alkyl hydroperoxide reductase
ZPR_RS08530	COG1054	Belongs to the UPF0176 family
ZPR_RS08535	COG1054	Belongs to the UPF0176 family
ZPR_RS08550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_RS08580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_RS08585	COG0783	Belongs to the Dps family
ZPR_RS08590	COG0783	Belongs to the Dps family
ZPR_RS08600	COG0737	Belongs to the 5'-nucleotidase family
ZPR_RS08610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS08615	COG0737	Belongs to the 5'-nucleotidase family
ZPR_RS08670	COG4974	Belongs to the 'phage' integrase family
ZPR_RS08675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZPR_RS08685	COG0592	DNA-directed DNA polymerase activity
ZPR_RS08710	COG1702	phosphate starvation-inducible protein PhoH
ZPR_RS08715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZPR_RS08720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ZPR_RS08740	COG1363	Peptidase, m42
ZPR_RS08785	COG0116	Belongs to the methyltransferase superfamily
ZPR_RS08800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZPR_RS08805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZPR_RS08840	COG1104	cysteine desulfurase activity
ZPR_RS08860	COG1418	mRNA catabolic process
ZPR_RS08865	COG0656	L-ascorbic acid biosynthetic process
ZPR_RS08870	COG4974	Belongs to the 'phage' integrase family
ZPR_RS08885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZPR_RS08895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS08905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZPR_RS08910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZPR_RS08925	COG2270	Major facilitator Superfamily
ZPR_RS08945	COG1595	DNA-templated transcription, initiation
ZPR_RS08950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ZPR_RS08955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZPR_RS08960	COG2814	Major facilitator Superfamily
ZPR_RS08965	COG0539	negative regulation of cytoplasmic translation
ZPR_RS09000	COG0346	lactoylglutathione lyase activity
ZPR_RS09005	COG4302	ethanolamine ammonia-lyase activity
ZPR_RS09010	COG4303	Ethanolamine ammonia lyase large subunit
ZPR_RS09015	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ZPR_RS09020	COG1764	response to oxidative stress
ZPR_RS09025	COG1846	Transcriptional regulator
ZPR_RS09030	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_RS09035	COG0590	tRNA wobble adenosine to inosine editing
ZPR_RS09045	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ZPR_RS09050	COG0540	Belongs to the ATCase OTCase family
ZPR_RS09060	COG1234	tRNA 3'-trailer cleavage
ZPR_RS09065	COG0259	pyridoxamine-phosphate oxidase activity
ZPR_RS09075	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZPR_RS09080	COG0248	Ppx GppA phosphatase
ZPR_RS09090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZPR_RS09095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZPR_RS09105	COG0745	RESPONSE REGULATOR receiver
ZPR_RS09110	COG0642	Histidine kinase
ZPR_RS09120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS09125	COG1477	protein flavinylation
ZPR_RS09185	COG4181	ATPase activity
ZPR_RS09225	COG0312	modulator of DNA gyrase
ZPR_RS09230	COG0312	modulator of DNA gyrase
ZPR_RS09240	COG0714	Associated with various cellular activities
ZPR_RS09270	COG3279	Response regulator of the LytR AlgR family
ZPR_RS09295	COG1538	Outer membrane efflux protein
ZPR_RS09305	COG4771	TonB-dependent receptor
ZPR_RS09315	COG1785	Belongs to the alkaline phosphatase family
ZPR_RS09320	COG1785	Belongs to the alkaline phosphatase family
ZPR_RS09345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ZPR_RS09350	COG0351	phosphomethylpyrimidine kinase
ZPR_RS09355	COG0352	thiamine-phosphate diphosphorylase activity
ZPR_RS09360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ZPR_RS09380	COG1733	regulation of RNA biosynthetic process
ZPR_RS09405	COG0730	response to heat
ZPR_RS09410	COG1271	oxidase subunit
ZPR_RS09420	COG3940	Belongs to the glycosyl hydrolase 43 family
ZPR_RS09425	COG1476	TRANSCRIPTIONal
ZPR_RS09470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_RS09480	COG0439	Biotin carboxylase
ZPR_RS09485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ZPR_RS09490	COG0107	imidazoleglycerol-phosphate synthase activity
ZPR_RS09495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZPR_RS09495	COG0140	phosphoribosyl-ATP diphosphatase activity
ZPR_RS09505	COG1741	Belongs to the pirin family
ZPR_RS09515	COG1942	4-Oxalocrotonate Tautomerase
ZPR_RS09520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ZPR_RS09535	COG0514	ATP-dependent DNA helicase (RecQ)
ZPR_RS09540	COG0598	Magnesium transport protein CorA
ZPR_RS09545	COG2706	6-phosphogluconolactonase activity
ZPR_RS09565	COG0745	RESPONSE REGULATOR receiver
ZPR_RS09575	COG0668	transmembrane transport
ZPR_RS09580	COG2957	Belongs to the agmatine deiminase family
ZPR_RS09585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZPR_RS09590	COG0545	Peptidyl-prolyl cis-trans isomerase
ZPR_RS09610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZPR_RS09610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZPR_RS09630	COG1595	DNA-templated transcription, initiation
ZPR_RS09635	COG1132	(ABC) transporter
ZPR_RS09640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZPR_RS09645	COG0463	Glycosyl transferase, family 2
ZPR_RS09655	COG0254	rRNA binding
ZPR_RS09680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZPR_RS09690	COG1741	Belongs to the pirin family
ZPR_RS09740	COG1607	acyl-coa hydrolase
ZPR_RS09765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZPR_RS09775	COG4206	TonB-dependent receptor
ZPR_RS09820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ZPR_RS09835	COG4771	TonB-dependent receptor
ZPR_RS09845	COG1045	serine acetyltransferase
ZPR_RS09870	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZPR_RS09890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ZPR_RS09900	COG0069	glutamate synthase activity
ZPR_RS09905	COG0589	response to stress
ZPR_RS09935	COG1842	Phage shock protein A
ZPR_RS09985	COG0670	Belongs to the BI1 family
ZPR_RS10000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ZPR_RS10015	COG1629	transport
ZPR_RS10020	COG0513	Belongs to the DEAD box helicase family
ZPR_RS10025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZPR_RS10030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZPR_RS10040	COG1295	ribonuclease BN
ZPR_RS10055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ZPR_RS10060	COG3279	Response regulator of the LytR AlgR family
ZPR_RS10065	COG0360	Binds together with S18 to 16S ribosomal RNA
ZPR_RS10070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZPR_RS10075	COG0359	binds to the 23S rRNA
ZPR_RS10085	COG0577	efflux transmembrane transporter activity
ZPR_RS10090	COG0124	histidyl-tRNA synthetase
ZPR_RS10110	COG4771	TonB-dependent receptor
ZPR_RS10135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_RS10140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ZPR_RS10150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZPR_RS10185	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_RS10200	COG0235	Class ii aldolase
ZPR_RS10205	COG2160	L-arabinose isomerase activity
ZPR_RS10230	COG4771	TonB-dependent receptor
ZPR_RS10260	COG3537	Alpha-1,2-mannosidase
ZPR_RS10390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ZPR_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS10435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS10455	COG3152	Membrane
ZPR_RS10470	COG4585	Histidine kinase
ZPR_RS10480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZPR_RS10490	COG3852	Histidine kinase
ZPR_RS10500	COG2076	Multidrug Resistance protein
ZPR_RS10505	COG3275	phosphorelay sensor kinase activity
ZPR_RS10510	COG3279	Response regulator of the LytR AlgR family
ZPR_RS10520	COG1482	cell wall glycoprotein biosynthetic process
ZPR_RS10530	COG4974	Belongs to the 'phage' integrase family
ZPR_RS10555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZPR_RS10570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS10615	COG2207	Transcriptional regulator
ZPR_RS10615	COG1609	Transcriptional regulator
ZPR_RS10630	COG0702	epimerase
ZPR_RS10635	COG4771	TonB-dependent receptor
ZPR_RS10695	COG0668	transmembrane transport
ZPR_RS10700	COG0783	Belongs to the Dps family
ZPR_RS10715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_RS10720	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ZPR_RS10725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ZPR_RS10730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ZPR_RS10770	COG0527	aspartate kinase activity
ZPR_RS10770	COG0460	homoserine dehydrogenase
ZPR_RS10775	COG0083	homoserine kinase activity
ZPR_RS10780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ZPR_RS10800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZPR_RS10805	COG4651	solute:proton antiporter activity
ZPR_RS10805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ZPR_RS10815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZPR_RS10820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZPR_RS10825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZPR_RS10835	COG4251	negative regulation of phosphorylation
ZPR_RS10850	COG0405	Gamma-glutamyltransferase
ZPR_RS10855	COG1187	pseudouridine synthase activity
ZPR_RS10870	COG0339	signal peptide processing
ZPR_RS10885	COG2084	Dehydrogenase
ZPR_RS10890	COG2116	formate transmembrane transporter activity
ZPR_RS10925	COG2217	Heavy metal translocating P-type atpase
ZPR_RS10935	COG3278	Belongs to the heme-copper respiratory oxidase family
ZPR_RS10950	COG0348	domain, Protein
ZPR_RS10990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZPR_RS10995	COG0415	Belongs to the DNA photolyase family
ZPR_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS11030	COG0668	transmembrane transport
ZPR_RS11040	COG0424	maF-like protein
ZPR_RS11060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZPR_RS11060	COG1333	cytochrome c biogenesis protein
ZPR_RS11085	COG1393	Belongs to the ArsC family
ZPR_RS11090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ZPR_RS11105	COG2308	Evidence 4 Homologs of previously reported genes of
ZPR_RS11130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZPR_RS11145	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_RS11180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZPR_RS11190	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZPR_RS11195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ZPR_RS11200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ZPR_RS11210	COG0686	Belongs to the AlaDH PNT family
ZPR_RS11220	COG0802	atpase or kinase
ZPR_RS11225	COG2204	response regulator
ZPR_RS11230	COG1078	dGTPase activity
ZPR_RS11235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_RS11240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZPR_RS11240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ZPR_RS11245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_RS11250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZPR_RS11255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZPR_RS11300	COG0612	Peptidase, M16
ZPR_RS11305	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS11320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZPR_RS11340	COG2801	Transposase and inactivated derivatives
ZPR_RS11345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZPR_RS11350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZPR_RS11355	COG0131	Imidazoleglycerol-phosphate dehydratase
ZPR_RS11360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZPR_RS11365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZPR_RS11375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_RS11390	COG2860	membrane
ZPR_RS11395	COG0492	ferredoxin-NADP+ reductase activity
ZPR_RS11445	COG3385	transposase activity
ZPR_RS11465	COG0714	Associated with various cellular activities
ZPR_RS11500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZPR_RS11505	COG0494	nUDIX hydrolase
ZPR_RS11530	COG1629	transport
ZPR_RS11530	COG4206	TonB-dependent receptor
ZPR_RS11540	COG3275	phosphorelay sensor kinase activity
ZPR_RS11555	COG3279	Response regulator of the LytR AlgR family
ZPR_RS11565	COG1595	DNA-templated transcription, initiation
ZPR_RS11585	COG0673	inositol 2-dehydrogenase activity
ZPR_RS11590	COG2211	Major facilitator Superfamily
ZPR_RS11630	COG0702	epimerase
ZPR_RS11635	COG1629	transport
ZPR_RS11635	COG4206	TonB-dependent receptor
ZPR_RS11670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
ZPR_RS11715	COG1960	acyl-CoA dehydrogenase activity
ZPR_RS11720	COG0183	Belongs to the thiolase family
ZPR_RS11725	COG1024	Enoyl-CoA hydratase
ZPR_RS11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
ZPR_RS11730	COG1846	Transcriptional regulator
ZPR_RS11735	COG1022	Amp-dependent synthetase and ligase
ZPR_RS11745	COG0047	phosphoribosylformylglycinamidine synthase activity
ZPR_RS11745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZPR_RS11755	COG0300	oxidoreductase activity
ZPR_RS11810	COG3292	Two component regulator propeller
ZPR_RS11810	COG2205	protein histidine kinase activity
ZPR_RS11810	COG0745	RESPONSE REGULATOR receiver
ZPR_RS11815	COG4771	TonB-dependent receptor
ZPR_RS11820	COG0702	epimerase
ZPR_RS11830	COG3250	beta-galactosidase activity
ZPR_RS11835	COG1501	Belongs to the glycosyl hydrolase 31 family
ZPR_RS11840	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_RS11850	COG1940	carbohydrate kinase activity
ZPR_RS11855	COG0673	inositol 2-dehydrogenase activity
ZPR_RS11865	COG3250	beta-galactosidase activity
ZPR_RS11885	COG4771	TonB-dependent receptor
ZPR_RS11900	COG0662	Cupin 2, conserved barrel domain protein
ZPR_RS11900	COG2207	Transcriptional regulator
ZPR_RS11935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ZPR_RS11975	COG1678	Uncharacterized ACR, COG1678
ZPR_RS11985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZPR_RS11990	COG0514	ATP-dependent DNA helicase (RecQ)
ZPR_RS12010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZPR_RS12020	COG4774	siderophore transport
ZPR_RS12030	COG0321	lipoyl(octanoyl) transferase activity
ZPR_RS12030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZPR_RS12040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ZPR_RS12045	COG0857	belongs to the CobB CobQ family
ZPR_RS12045	COG0280	phosphate acetyltransferase
ZPR_RS12060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZPR_RS12070	COG2205	protein histidine kinase activity
ZPR_RS12085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZPR_RS12090	COG0302	gtp cyclohydrolase
ZPR_RS12110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZPR_RS12120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZPR_RS12130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS12135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZPR_RS12140	COG0745	RESPONSE REGULATOR receiver
ZPR_RS12145	COG5002	protein histidine kinase activity
ZPR_RS12190	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ZPR_RS12200	COG1764	response to oxidative stress
ZPR_RS12205	COG1047	Peptidyl-prolyl cis-trans
ZPR_RS12210	COG0673	inositol 2-dehydrogenase activity
ZPR_RS12230	COG0527	aspartate kinase activity
ZPR_RS12245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZPR_RS12250	COG3265	gluconokinase activity
ZPR_RS12255	COG2610	gluconate transmembrane transporter activity
ZPR_RS12265	COG0217	transcriptional regulatory protein
ZPR_RS12270	COG2154	pterin-4-alpha-carbinolamine dehydratase
ZPR_RS12280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ZPR_RS12285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ZPR_RS12285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ZPR_RS12290	COG2986	histidine ammonia-lyase
ZPR_RS12300	COG0542	response to heat
ZPR_RS12305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZPR_RS12320	COG0183	Belongs to the thiolase family
ZPR_RS12350	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_RS12360	COG1051	belongs to the nudix hydrolase family
ZPR_RS12365	COG1607	acyl-coa hydrolase
ZPR_RS12370	COG0668	transmembrane transport
ZPR_RS12380	COG0668	transmembrane transport
ZPR_RS12385	COG2814	Major facilitator Superfamily
ZPR_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS12420	COG2072	flavoprotein involved in K transport
ZPR_RS12425	COG4221	oxidoreductase activity
ZPR_RS12430	COG2130	NADP-dependent
ZPR_RS12435	COG1289	transmembrane transporter activity
ZPR_RS12455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZPR_RS12475	COG1902	pentaerythritol trinitrate reductase activity
ZPR_RS12485	COG0604	alcohol dehydrogenase
ZPR_RS12500	COG1917	Cupin 2, conserved barrel domain protein
ZPR_RS12500	COG2169	Transcriptional regulator
ZPR_RS12515	COG2211	Major facilitator Superfamily
ZPR_RS12520	COG0583	DNA-binding transcription factor activity
ZPR_RS12525	COG2855	membrane
ZPR_RS12530	COG0698	ribose 5-phosphate isomerase
ZPR_RS12535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ZPR_RS12540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZPR_RS12545	COG0363	glucosamine-6-phosphate deaminase activity
ZPR_RS12560	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ZPR_RS12565	COG3384	dioxygenase
ZPR_RS12580	COG2723	6-phospho-beta-galactosidase activity
ZPR_RS12760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZPR_RS12790	COG0023	Translation Initiation Factor
ZPR_RS12800	COG0813	purine-nucleoside phosphorylase activity
ZPR_RS12805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZPR_RS12815	COG2801	Transposase and inactivated derivatives
ZPR_RS12820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ZPR_RS12825	COG1193	negative regulation of DNA recombination
ZPR_RS12830	COG3011	Protein conserved in bacteria
ZPR_RS12850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZPR_RS12865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZPR_RS12875	COG0693	protein deglycase activity
ZPR_RS12890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZPR_RS12895	COG1522	sequence-specific DNA binding
ZPR_RS12915	COG1970	mechanosensitive ion channel activity
ZPR_RS12935	COG0012	GTP binding
ZPR_RS12945	COG2226	methyltransferase
ZPR_RS12950	COG3507	Belongs to the glycosyl hydrolase 43 family
ZPR_RS12955	COG3537	Alpha-1,2-mannosidase
ZPR_RS12960	COG3537	Alpha-1,2-mannosidase
ZPR_RS12970	COG0247	lactate metabolic process
ZPR_RS12980	COG0438	transferase activity, transferring glycosyl groups
ZPR_RS12985	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS12995	COG2181	nitrate reductase activity
ZPR_RS12995	COG0247	lactate metabolic process
ZPR_RS13000	COG0247	lactate metabolic process
ZPR_RS13000	COG2181	nitrate reductase activity
ZPR_RS13010	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZPR_RS13020	COG0251	oxidation-reduction process
ZPR_RS13025	COG0667	Aldo Keto reductase
ZPR_RS13035	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ZPR_RS13045	COG1803	Methylglyoxal synthase
ZPR_RS13050	COG0205	6-phosphofructokinase activity
ZPR_RS13060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZPR_RS13115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZPR_RS13125	COG0726	polysaccharide deacetylase
ZPR_RS13135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZPR_RS13160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZPR_RS13170	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS13175	COG2986	histidine ammonia-lyase
ZPR_RS13195	COG4974	Belongs to the 'phage' integrase family
ZPR_RS13255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZPR_RS13260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZPR_RS13265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZPR_RS13270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ZPR_RS13275	COG0137	argininosuccinate synthase activity
ZPR_RS13285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZPR_RS13290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZPR_RS13300	COG0028	Belongs to the TPP enzyme family
ZPR_RS13305	COG0129	dihydroxy-acid dehydratase activity
ZPR_RS13310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZPR_RS13310	COG3153	acetyltransferase
ZPR_RS13315	COG2197	response regulator
ZPR_RS13320	COG1984	allophanate hydrolase subunit 2
ZPR_RS13325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ZPR_RS13335	COG1914	H( )-stimulated, divalent metal cation uptake system
ZPR_RS13345	COG0606	chelatase, subunit chli
ZPR_RS13355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZPR_RS13360	COG0205	6-phosphofructokinase activity
ZPR_RS13365	COG0366	Alpha amylase catalytic
ZPR_RS13370	COG0366	Alpha amylase catalytic
ZPR_RS13375	COG1082	Xylose isomerase domain protein TIM barrel
ZPR_RS13380	COG1554	hydrolase, family 65, central catalytic
ZPR_RS13385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZPR_RS13400	COG4206	TonB-dependent receptor
ZPR_RS13400	COG1629	transport
ZPR_RS13405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZPR_RS13415	COG0366	Alpha amylase catalytic
ZPR_RS13450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ZPR_RS13455	COG1085	galactose-1-phosphate uridylyltransferase
ZPR_RS13480	COG4232	protein-disulfide reductase activity
ZPR_RS13485	COG0037	tRNA processing
ZPR_RS13505	COG0513	Belongs to the DEAD box helicase family
ZPR_RS13510	COG3275	phosphorelay sensor kinase activity
ZPR_RS13520	COG3279	Response regulator of the LytR AlgR family
ZPR_RS13535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS13540	COG1757	Na H antiporter
ZPR_RS13545	COG0450	alkyl hydroperoxide reductase
ZPR_RS13570	COG1674	ftsk spoiiie
ZPR_RS13585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZPR_RS13585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZPR_RS13610	COG4771	TonB-dependent receptor
ZPR_RS13615	COG0561	phosphatase activity
ZPR_RS13635	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_RS13640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZPR_RS13645	COG0420	3'-5' exonuclease activity
ZPR_RS13650	COG0419	ATPase involved in DNA repair
ZPR_RS13660	COG1272	protein, Hemolysin III
ZPR_RS13735	COG0673	inositol 2-dehydrogenase activity
ZPR_RS13750	COG4771	TonB-dependent receptor
ZPR_RS13765	COG1609	Transcriptional regulator
ZPR_RS13785	COG2201	protein-glutamate methylesterase activity
ZPR_RS13790	COG3530	Putative quorum-sensing-regulated virulence factor
ZPR_RS13795	COG0504	CTP synthase activity
ZPR_RS13800	COG0706	membrane insertase activity
ZPR_RS13810	COG0519	Catalyzes the synthesis of GMP from XMP
ZPR_RS13810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZPR_RS13815	COG3942	CHAP domain
ZPR_RS13815	COG1388	LysM domain
ZPR_RS13825	COG1335	isochorismatase
ZPR_RS13845	COG0482	sulfurtransferase activity
ZPR_RS13870	COG3002	Belongs to the UPF0753 family
ZPR_RS13875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ZPR_RS13880	COG0076	glutamate decarboxylase activity
ZPR_RS13885	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ZPR_RS13905	COG2205	protein histidine kinase activity
ZPR_RS13905	COG3292	Two component regulator propeller
ZPR_RS13905	COG0745	RESPONSE REGULATOR receiver
ZPR_RS13910	COG1501	Belongs to the glycosyl hydrolase 31 family
ZPR_RS13915	COG4206	TonB-dependent receptor
ZPR_RS13915	COG1629	transport
ZPR_RS13920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZPR_RS13925	COG3250	beta-galactosidase activity
ZPR_RS13930	COG0702	epimerase
ZPR_RS13945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZPR_RS13985	COG2721	sulfolactate sulfo-lyase activity
ZPR_RS13990	COG0246	Mannitol dehydrogenase
ZPR_RS14000	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ZPR_RS14010	COG0800	Aldolase
ZPR_RS14015	COG1304	FMN binding
ZPR_RS14025	COG1904	glucuronate isomerase
ZPR_RS14030	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS14035	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ZPR_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS14065	COG1312	Catalyzes the dehydration of D-mannonate
ZPR_RS14070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ZPR_RS14080	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ZPR_RS14085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ZPR_RS14085	COG2010	Cytochrome c
ZPR_RS14090	COG2080	2 iron, 2 sulfur cluster binding
ZPR_RS14100	COG0314	molybdopterin synthase activity
ZPR_RS14105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ZPR_RS14110	COG0315	cyclic pyranopterin monophosphate synthase activity
ZPR_RS14115	COG0315	cyclic pyranopterin monophosphate synthase activity
ZPR_RS14115	COG0746	molybdenum cofactor guanylyltransferase activity
ZPR_RS14120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZPR_RS14140	COG3842	ATPase activity
ZPR_RS14145	COG0303	'Molybdopterin
ZPR_RS14150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ZPR_RS14155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ZPR_RS14160	COG2080	2 iron, 2 sulfur cluster binding
ZPR_RS14165	COG0673	inositol 2-dehydrogenase activity
ZPR_RS14185	COG2115	Belongs to the xylose isomerase family
ZPR_RS14195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_RS14285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZPR_RS14285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZPR_RS14315	COG2814	Major facilitator Superfamily
ZPR_RS14315	COG0477	Major facilitator Superfamily
ZPR_RS14345	COG1609	Transcriptional regulator
ZPR_RS14355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ZPR_RS14360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ZPR_RS14365	COG1904	glucuronate isomerase
ZPR_RS14370	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS14375	COG3661	Belongs to the glycosyl hydrolase 67 family
ZPR_RS14380	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS14395	COG0702	epimerase
ZPR_RS14400	COG1629	transport
ZPR_RS14410	COG0671	phosphoesterase, PA-phosphatase related
ZPR_RS14420	COG0534	Mate efflux family protein
ZPR_RS14440	COG0071	Belongs to the small heat shock protein (HSP20) family
ZPR_RS14450	COG4585	Histidine kinase
ZPR_RS14455	COG2197	response regulator
ZPR_RS14460	COG0488	(ABC) transporter
ZPR_RS14475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ZPR_RS14505	COG1266	CAAX protease self-immunity
ZPR_RS14510	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_RS14515	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ZPR_RS14520	COG1575	Belongs to the MenA family. Type 1 subfamily
ZPR_RS14540	COG1360	Flagellar Motor Protein
ZPR_RS14545	COG2267	carboxylic ester hydrolase activity
ZPR_RS14555	COG0702	epimerase
ZPR_RS14560	COG1629	transport
ZPR_RS14570	COG2885	chlorophyll binding
ZPR_RS14600	COG0668	transmembrane transport
ZPR_RS14635	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_RS14645	COG4106	trans-aconitate 2-methyltransferase activity
ZPR_RS14660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZPR_RS14675	COG0242	peptide deformylase activity
ZPR_RS14680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZPR_RS14685	COG2171	N-acyltransferase activity
ZPR_RS14710	COG0009	L-threonylcarbamoyladenylate synthase
ZPR_RS14715	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ZPR_RS14715	COG0617	tRNA 3'-terminal CCA addition
ZPR_RS14715	COG0517	IMP dehydrogenase activity
ZPR_RS14760	COG0556	nucleotide-excision repair
ZPR_RS14770	COG2204	response regulator
ZPR_RS14780	COG3264	Mechanosensitive ion channel
ZPR_RS14780	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ZPR_RS14785	COG1668	transmembrane transport
ZPR_RS14790	COG4152	abc transporter atp-binding protein
ZPR_RS14800	COG0484	heat shock protein binding
ZPR_RS14805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZPR_RS14820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ZPR_RS14820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZPR_RS14830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZPR_RS14855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ZPR_RS14860	COG0347	Belongs to the P(II) protein family
ZPR_RS14865	COG0004	ammonium transporteR
ZPR_RS14890	COG2226	methyltransferase
ZPR_RS14895	COG1522	sequence-specific DNA binding
ZPR_RS14905	COG2095	MarC family integral membrane protein
ZPR_RS14910	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_RS14910	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ZPR_RS14910	COG1703	isobutyryl-CoA mutase activity
ZPR_RS14915	COG0788	formyltetrahydrofolate deformylase activity
ZPR_RS14920	COG0753	catalase activity
ZPR_RS14935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ZPR_RS14940	COG0284	orotidine-5'-phosphate decarboxylase activity
ZPR_RS14945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZPR_RS14955	COG1131	(ABC) transporter
ZPR_RS14965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZPR_RS14975	COG0174	glutamine synthetase
ZPR_RS15045	COG0702	epimerase
ZPR_RS15050	COG4771	TonB-dependent receptor
ZPR_RS15055	COG2814	Major facilitator Superfamily
ZPR_RS15110	COG0523	cobalamin synthesis protein
ZPR_RS15120	COG1785	Belongs to the alkaline phosphatase family
ZPR_RS15130	COG4771	TonB-dependent receptor
ZPR_RS15135	COG0702	epimerase
ZPR_RS15155	COG0702	epimerase
ZPR_RS15160	COG4771	TonB-dependent receptor
ZPR_RS15165	COG1621	beta-fructofuranosidase activity
ZPR_RS15170	COG2814	Major facilitator Superfamily
ZPR_RS15175	COG2205	protein histidine kinase activity
ZPR_RS15175	COG0745	RESPONSE REGULATOR receiver
ZPR_RS15175	COG3292	Two component regulator propeller
ZPR_RS15185	COG1595	DNA-templated transcription, initiation
ZPR_RS15205	COG3511	phospholipase C
ZPR_RS15215	COG4771	TonB-dependent receptor
ZPR_RS15255	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_RS15260	COG1074	ATP-dependent DNA helicase activity
ZPR_RS15285	COG2234	aminopeptidase activity
ZPR_RS15295	COG2801	Transposase and inactivated derivatives
ZPR_RS15300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ZPR_RS15310	COG1250	3-hydroxyacyl-CoA dehydrogenase
ZPR_RS15320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ZPR_RS15325	COG0322	excinuclease ABC activity
ZPR_RS15335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ZPR_RS15340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZPR_RS15370	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZPR_RS15375	COG0497	DNA recombination
ZPR_RS15400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZPR_RS15410	COG0737	Belongs to the 5'-nucleotidase family
ZPR_RS15410	COG1525	nuclease
ZPR_RS15410	COG4085	toxin activity
ZPR_RS15415	COG0737	Belongs to the 5'-nucleotidase family
ZPR_RS15425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZPR_RS15480	COG4771	TonB-dependent receptor
ZPR_RS15500	COG4974	Belongs to the 'phage' integrase family
ZPR_RS15650	COG2378	regulation of single-species biofilm formation
ZPR_RS15725	COG2963	transposase activity
ZPR_RS15745	COG1309	transcriptional regulator
ZPR_RS15760	COG0519	Catalyzes the synthesis of GMP from XMP
ZPR_RS15765	COG4977	sequence-specific DNA binding
ZPR_RS15765	COG1917	Cupin 2, conserved barrel domain protein
ZPR_RS15770	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS15815	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ZPR_RS15835	COG3685	Protein conserved in bacteria
ZPR_RS15840	COG2124	cytochrome p450
ZPR_RS15850	COG0401	homolog of Blt101
ZPR_RS15895	COG2801	Transposase and inactivated derivatives
ZPR_RS15900	COG2801	Transposase and inactivated derivatives
ZPR_RS15910	COG0401	homolog of Blt101
ZPR_RS15920	COG3685	Protein conserved in bacteria
ZPR_RS15930	COG5002	protein histidine kinase activity
ZPR_RS15960	COG2217	Heavy metal translocating P-type atpase
ZPR_RS15985	COG0640	Transcriptional regulator
ZPR_RS15995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS16035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_RS16095	COG0531	amino acid
ZPR_RS16105	COG1830	Aldolase
ZPR_RS16110	COG1301	dicarboxylic acid transport
ZPR_RS16115	COG0596	Alpha beta hydrolase
ZPR_RS16120	COG0205	6-phosphofructokinase activity
ZPR_RS16125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZPR_RS16145	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ZPR_RS16150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ZPR_RS16155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZPR_RS16170	COG2217	Heavy metal translocating P-type atpase
ZPR_RS16175	COG2814	Major facilitator Superfamily
ZPR_RS16185	COG4372	Transposase
ZPR_RS16220	COG1618	nucleotide phosphatase activity, acting on free nucleotides
ZPR_RS16240	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ZPR_RS16245	COG4804	nuclease activity
ZPR_RS16250	COG5290	Psort location Cytoplasmic, score
ZPR_RS16260	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ZPR_RS16290	COG4771	TonB-dependent receptor
ZPR_RS16310	COG2207	Transcriptional regulator
ZPR_RS16320	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_RS16420	COG3119	arylsulfatase activity
ZPR_RS16430	COG2382	esterase
ZPR_RS16430	COG3693	PFAM glycoside hydrolase, family 10
ZPR_RS16440	COG2272	Belongs to the type-B carboxylesterase lipase family
ZPR_RS16445	COG2942	2-epimerase
ZPR_RS16450	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ZPR_RS16480	COG0702	epimerase
ZPR_RS16485	COG1629	transport
ZPR_RS16485	COG4206	TonB-dependent receptor
ZPR_RS16495	COG4771	TonB-dependent receptor
ZPR_RS16520	COG3328	transposase activity
ZPR_RS16555	COG2827	Endonuclease containing a URI domain
ZPR_RS16560	COG1610	YqeY-like protein
ZPR_RS16570	COG3250	beta-galactosidase activity
ZPR_RS16575	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS16580	COG3119	arylsulfatase activity
ZPR_RS16595	COG0702	epimerase
ZPR_RS16600	COG4771	TonB-dependent receptor
ZPR_RS16635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZPR_RS16640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZPR_RS16645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZPR_RS16670	COG1490	D-aminoacyl-tRNA deacylase activity
ZPR_RS16675	COG1162	GTPase activity
ZPR_RS16680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ZPR_RS16685	COG0287	Prephenate dehydrogenase
ZPR_RS16690	COG0436	Aminotransferase
ZPR_RS16695	COG0077	Prephenate dehydratase
ZPR_RS16695	COG1605	Chorismate mutase
ZPR_RS16700	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZPR_RS16765	COG3590	peptidase
ZPR_RS16790	COG2801	Transposase and inactivated derivatives
ZPR_RS16805	COG0612	Peptidase, M16
ZPR_RS16820	COG1629	transport
ZPR_RS16850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZPR_RS16900	COG0784	Response regulator, receiver
ZPR_RS16910	COG4251	negative regulation of phosphorylation
ZPR_RS16920	COG5002	protein histidine kinase activity
ZPR_RS16930	COG3279	Response regulator of the LytR AlgR family
ZPR_RS16945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZPR_RS16960	COG1611	Belongs to the LOG family
ZPR_RS16965	COG2890	protein-(glutamine-N5) methyltransferase activity
ZPR_RS16975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZPR_RS16975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZPR_RS16980	COG1011	Hydrolase
ZPR_RS16985	COG1739	Uncharacterized protein family UPF0029
ZPR_RS16990	COG0824	Thioesterase
ZPR_RS16995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZPR_RS17000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZPR_RS17005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZPR_RS17015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZPR_RS17025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZPR_RS17030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZPR_RS17050	COG0336	Belongs to the RNA methyltransferase TrmD family
ZPR_RS17055	COG0335	large ribosomal subunit rRNA binding
ZPR_RS17065	COG2814	Major facilitator Superfamily
ZPR_RS17100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZPR_RS17105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZPR_RS17110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ZPR_RS17115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZPR_RS17125	COG1217	gtp-binding protein TYPA
ZPR_RS17145	COG0460	homoserine dehydrogenase
ZPR_RS17145	COG0527	aspartate kinase activity
ZPR_RS17150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ZPR_RS17160	COG1410	methionine synthase
ZPR_RS17160	COG0646	methionine synthase
ZPR_RS17165	COG1765	OsmC-like protein
ZPR_RS17170	COG0492	ferredoxin-NADP+ reductase activity
ZPR_RS17175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZPR_RS17175	COG1648	precorrin-2 dehydrogenase activity
ZPR_RS17185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZPR_RS17195	COG1959	2 iron, 2 sulfur cluster binding
ZPR_RS17210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZPR_RS17225	COG1960	acyl-CoA dehydrogenase activity
ZPR_RS17230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZPR_RS17240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZPR_RS17255	COG3273	potassium ion transport
ZPR_RS17255	COG0471	metal ion transport
ZPR_RS17275	COG1012	belongs to the aldehyde dehydrogenase family
ZPR_RS17280	COG2207	Transcriptional regulator
ZPR_RS17285	COG1428	Deoxynucleoside kinase
ZPR_RS17305	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ZPR_RS17310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZPR_RS17320	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_RS17320	COG0022	dehydrogenase e1 component
ZPR_RS17330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ZPR_RS17340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZPR_RS17355	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZPR_RS17370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_RS17400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ZPR_RS17415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZPR_RS17420	COG1629	transport
ZPR_RS17445	COG0673	inositol 2-dehydrogenase activity
ZPR_RS17455	COG1519	Transferase
ZPR_RS17455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZPR_RS17490	COG0702	epimerase
ZPR_RS17495	COG4771	TonB-dependent receptor
ZPR_RS17510	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ZPR_RS17540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ZPR_RS17555	COG2249	NAD(P)H dehydrogenase (quinone) activity
ZPR_RS17595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZPR_RS17605	COG1119	ATPase activity
ZPR_RS17610	COG0657	acetylesterase activity
ZPR_RS17610	COG2755	lipolytic protein G-D-S-L family
ZPR_RS17655	COG0823	Involved in the tonB-independent uptake of proteins
ZPR_RS17670	COG1428	Deoxynucleoside kinase
ZPR_RS17685	COG0525	valine-tRNA ligase activity
ZPR_RS17695	COG0436	Aminotransferase
ZPR_RS17700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZPR_RS17715	COG1216	Glycosyl transferase, family 2
ZPR_RS17725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZPR_RS17730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZPR_RS17740	COG1663	tetraacyldisaccharide 4'-kinase activity
ZPR_RS17745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ZPR_RS17765	COG3263	regulation of cellular component size
ZPR_RS17770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZPR_RS17785	COG0415	Belongs to the DNA photolyase family
ZPR_RS17790	COG3046	protein related to deoxyribodipyrimidine photolyase
ZPR_RS17795	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS17810	COG3844	kynureninase activity
ZPR_RS17820	COG0671	phosphoesterase, PA-phosphatase related
ZPR_RS17825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZPR_RS17860	COG3340	Belongs to the peptidase S51 family
ZPR_RS17865	COG2066	Belongs to the glutaminase family
ZPR_RS17870	COG0268	Binds directly to 16S ribosomal RNA
ZPR_RS17885	COG0442	prolyl-tRNA aminoacylation
ZPR_RS17905	COG0302	gtp cyclohydrolase
ZPR_RS17910	COG0215	cysteine-tRNA ligase activity
ZPR_RS17915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZPR_RS17920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZPR_RS17930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZPR_RS17940	COG0187	DNA topoisomerase II activity
ZPR_RS17950	COG0602	queuosine metabolic process
ZPR_RS17965	COG4771	TonB-dependent receptor
ZPR_RS17975	COG1619	proteins homologs of microcin C7 resistance protein MccF
ZPR_RS17995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZPR_RS18010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZPR_RS18015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZPR_RS18025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZPR_RS18030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZPR_RS18035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZPR_RS18040	COG0768	penicillin binding
ZPR_RS18050	COG0275	rRNA processing
ZPR_RS18055	COG2001	Belongs to the MraZ family
ZPR_RS18065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZPR_RS18090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ZPR_RS18095	COG2197	response regulator
ZPR_RS18100	COG0358	DNA primase activity
ZPR_RS18100	COG0305	Participates in initiation and elongation during chromosome replication
ZPR_RS18120	COG1187	pseudouridine synthase activity
ZPR_RS18140	COG3339	Conserved Protein
ZPR_RS18145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZPR_RS18150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZPR_RS18155	COG0018	arginyl-trna synthetase
ZPR_RS18165	COG2095	MarC family integral membrane protein
ZPR_RS18180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ZPR_RS18200	COG0297	glycogen (starch) synthase activity
ZPR_RS18205	COG0148	phosphopyruvate hydratase activity
ZPR_RS18210	COG0505	Belongs to the CarA family
ZPR_RS18215	COG0203	ribosomal protein L17
ZPR_RS18220	COG0202	RNA polymerase activity
ZPR_RS18225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZPR_RS18230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZPR_RS18235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZPR_RS18240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZPR_RS18250	COG0200	Binds to the 23S rRNA
ZPR_RS18255	COG1841	ribosomal large subunit assembly
ZPR_RS18260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZPR_RS18265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZPR_RS18270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZPR_RS18275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZPR_RS18280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZPR_RS18285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZPR_RS18290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZPR_RS18295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZPR_RS18300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZPR_RS18305	COG0255	Belongs to the universal ribosomal protein uL29 family
ZPR_RS18310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZPR_RS18315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZPR_RS18320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZPR_RS18325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZPR_RS18330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZPR_RS18335	COG0089	rRNA binding
ZPR_RS18340	COG0088	Forms part of the polypeptide exit tunnel
ZPR_RS18345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZPR_RS18350	COG0051	transcription antitermination factor activity, RNA binding
ZPR_RS18355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZPR_RS18360	COG0049	tRNA binding
ZPR_RS18365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZPR_RS18370	COG4771	TonB-dependent receptor
ZPR_RS18380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZPR_RS18385	COG4771	TonB-dependent receptor
ZPR_RS18405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZPR_RS18425	COG2003	Belongs to the UPF0758 family
ZPR_RS18430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZPR_RS18465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZPR_RS18470	COG0563	adenylate kinase activity
ZPR_RS18480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZPR_RS18485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZPR_RS18490	COG0339	signal peptide processing
ZPR_RS18510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ZPR_RS18510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ZPR_RS18515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZPR_RS18535	COG1215	transferase activity, transferring glycosyl groups
ZPR_RS18545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZPR_RS18550	COG1127	ABC transporter
ZPR_RS18565	COG0300	oxidoreductase activity
ZPR_RS18580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZPR_RS18585	COG0295	cytidine deaminase activity
ZPR_RS18595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_RS18600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ZPR_RS18615	COG0285	dihydrofolate synthase activity
ZPR_RS18625	COG0848	biopolymer transport protein
ZPR_RS18630	COG0811	peptide transport
ZPR_RS18635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ZPR_RS18645	COG1960	acyl-CoA dehydrogenase activity
ZPR_RS18650	COG0070	glutamate synthase
ZPR_RS18650	COG0069	glutamate synthase activity
ZPR_RS18650	COG0067	glutamate synthase
ZPR_RS18670	COG0563	adenylate kinase activity
ZPR_RS18820	COG4372	Transposase
ZPR_RS18830	COG4974	Belongs to the 'phage' integrase family
ZPR_RS18905	COG3621	Patatin-like phospholipase
ZPR_RS18975	COG2003	Belongs to the UPF0758 family
ZPR_RS18980	COG0629	single-stranded DNA binding
ZPR_RS19020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS19055	COG2814	Major facilitator Superfamily
ZPR_RS19150	COG0723	plastoquinol--plastocyanin reductase activity
ZPR_RS19170	COG0531	amino acid
ZPR_RS19185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZPR_RS19195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZPR_RS19200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS19215	COG2132	Multicopper oxidase
ZPR_RS19220	COG2217	Heavy metal translocating P-type atpase
ZPR_RS19235	COG3781	membrane
ZPR_RS19285	COG0347	Belongs to the P(II) protein family
ZPR_RS19350	COG4771	TonB-dependent receptor
ZPR_RS19355	COG0702	epimerase
ZPR_RS19360	COG0612	Peptidase, M16
ZPR_RS19370	COG1609	Transcriptional regulator
ZPR_RS19370	COG2207	Transcriptional regulator
ZPR_RS19395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZPR_RS19405	COG1309	transcriptional regulator
ZPR_RS19410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS19415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_RS19425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
ZPR_RS19480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ZPR_RS19530	COG2003	Belongs to the UPF0758 family
ZPR_RS19535	COG0629	single-stranded DNA binding
ZPR_RS19580	COG0488	(ABC) transporter
ZPR_RS19610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_RS19620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZPR_RS19620	COG1754	DNA topoisomerase type I activity
ZPR_RS19625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZPR_RS19650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZPR_RS19655	COG0459	protein refolding
ZPR_RS19660	COG3142	Participates in the control of copper homeostasis
ZPR_RS19695	COG0471	metal ion transport
ZPR_RS19720	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS19735	COG1629	transport
ZPR_RS19745	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZPR_RS19750	COG3537	Alpha-1,2-mannosidase
ZPR_RS19765	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
ZPR_RS19775	COG3537	Alpha-1,2-mannosidase
ZPR_RS19785	COG3279	Response regulator of the LytR AlgR family
ZPR_RS19810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ZPR_RS19815	COG2226	methyltransferase
ZPR_RS19830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZPR_RS19845	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ZPR_RS19850	COG0463	Glycosyl transferase, family 2
ZPR_RS19855	COG1215	transferase activity, transferring glycosyl groups
ZPR_RS19880	COG0010	Belongs to the arginase family
ZPR_RS19890	COG1187	pseudouridine synthase activity
ZPR_RS19910	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ZPR_RS19915	COG2081	HI0933 family
ZPR_RS19925	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS19930	COG2323	membrane
ZPR_RS19940	COG0861	Integral membrane protein TerC family
ZPR_RS19955	COG0673	inositol 2-dehydrogenase activity
ZPR_RS19960	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ZPR_RS19975	COG4771	TonB-dependent receptor
ZPR_RS19990	COG4771	TonB-dependent receptor
ZPR_RS20025	COG2217	Heavy metal translocating P-type atpase
ZPR_RS20035	COG2207	Transcriptional regulator
ZPR_RS20055	COG2217	Heavy metal translocating P-type atpase
ZPR_RS20100	COG0069	glutamate synthase activity
ZPR_RS20135	COG2132	Multicopper oxidase
ZPR_RS20150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZPR_RS20190	COG0629	single-stranded DNA binding
ZPR_RS20195	COG0629	single-stranded DNA binding
ZPR_RS20220	COG2814	Major facilitator Superfamily
ZPR_RS20260	COG1475	DNA binding
ZPR_RS20275	COG0739	heme binding
ZPR_RS20295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZPR_RS20300	COG2315	Protein conserved in bacteria
ZPR_RS20320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZPR_RS20325	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZPR_RS20345	COG3063	Type IV pilus biogenesis stability protein PilW
ZPR_RS20380	COG0784	Response regulator, receiver
ZPR_RS20380	COG5002	protein histidine kinase activity
ZPR_RS20380	COG2198	Histidine kinase
ZPR_RS20390	COG1346	cytolysis
ZPR_RS20395	COG1380	Effector of murein hydrolase LrgA
ZPR_RS20405	COG3525	Glycosyl hydrolase, family 20, catalytic domain
ZPR_RS20410	COG2072	flavoprotein involved in K transport
ZPR_RS20435	COG1607	acyl-coa hydrolase
ZPR_RS20445	COG4221	oxidoreductase activity
ZPR_RS20495	COG3250	beta-galactosidase activity
ZPR_RS20510	COG2017	converts alpha-aldose to the beta-anomer
ZPR_RS20520	COG3940	Belongs to the glycosyl hydrolase 43 family
ZPR_RS20540	COG2205	protein histidine kinase activity
ZPR_RS20540	COG3292	Two component regulator propeller
ZPR_RS20540	COG0745	RESPONSE REGULATOR receiver
ZPR_RS20555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS20585	COG1522	sequence-specific DNA binding
ZPR_RS20590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZPR_RS20595	COG0778	Nitroreductase
ZPR_RS20615	COG3254	rhamnose metabolic process
ZPR_RS20620	COG0738	Major facilitator superfamily
ZPR_RS20630	COG3618	amidohydrolase
ZPR_RS20635	COG1063	alcohol dehydrogenase
ZPR_RS20645	COG4977	sequence-specific DNA binding
ZPR_RS20650	COG2207	Transcriptional regulator
ZPR_RS20655	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_RS20665	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS20670	COG0179	Fumarylacetoacetate (FAA) hydrolase
ZPR_RS20680	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS20700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZPR_RS20705	COG1966	Carbon starvation protein
ZPR_RS20735	COG0702	epimerase
ZPR_RS20740	COG1629	transport
ZPR_RS20745	COG3537	Alpha-1,2-mannosidase
ZPR_RS20750	COG2188	Transcriptional regulator
ZPR_RS20755	COG3119	arylsulfatase activity
ZPR_RS20770	COG4771	TonB-dependent receptor
ZPR_RS20775	COG0702	epimerase
ZPR_RS20795	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS20845	COG3177	Filamentation induced by cAMP protein fic
ZPR_RS20890	COG2003	Belongs to the UPF0758 family
ZPR_RS20895	COG0629	single-stranded DNA binding
ZPR_RS20930	COG2827	Endonuclease containing a URI domain
ZPR_RS20935	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ZPR_RS20950	COG2801	Transposase and inactivated derivatives
ZPR_RS20960	COG3118	belongs to the thioredoxin family
ZPR_RS20975	COG3279	Response regulator of the LytR AlgR family
ZPR_RS20985	COG0228	four-way junction DNA binding
ZPR_RS20990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZPR_RS20995	COG0495	leucyl-tRNA aminoacylation
ZPR_RS21005	COG2177	Part of the ABC transporter FtsEX involved in
ZPR_RS21015	COG1968	undecaprenyl-diphosphatase activity
ZPR_RS21020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZPR_RS21035	COG0519	Catalyzes the synthesis of GMP from XMP
ZPR_RS21045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZPR_RS21055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ZPR_RS21060	COG5002	protein histidine kinase activity
ZPR_RS21075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZPR_RS21090	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS21115	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ZPR_RS21145	COG1733	regulation of RNA biosynthetic process
ZPR_RS21150	COG0702	epimerase
ZPR_RS21155	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ZPR_RS21165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZPR_RS21190	COG1629	transport
ZPR_RS21200	COG3279	Response regulator of the LytR AlgR family
ZPR_RS21205	COG4585	Histidine kinase
ZPR_RS21210	COG3279	Response regulator of the LytR AlgR family
ZPR_RS21215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZPR_RS21220	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZPR_RS21230	COG0612	Peptidase, M16
ZPR_RS21235	COG0612	Peptidase, M16
ZPR_RS21265	COG0776	regulation of translation
ZPR_RS21270	COG1530	ribonuclease E activity
ZPR_RS21280	COG2137	regulation of response to DNA damage stimulus
ZPR_RS21305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZPR_RS21310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZPR_RS21315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZPR_RS21320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZPR_RS21325	COG0156	8-amino-7-oxononanoate synthase activity
ZPR_RS21330	COG1320	monovalent cation:proton antiporter activity
ZPR_RS21335	COG2212	antiporter activity
ZPR_RS21340	COG1863	multisubunit Na H antiporter MnhE subunit
ZPR_RS21345	COG0651	ATP synthesis coupled electron transport
ZPR_RS21350	COG1006	Multisubunit Na H antiporter MnhC subunit
ZPR_RS21355	COG2111	Na H antiporter
ZPR_RS21360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ZPR_RS21360	COG2111	Na H antiporter
ZPR_RS21370	COG3655	Transcriptional regulator
ZPR_RS21380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZPR_RS21385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZPR_RS21390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZPR_RS21400	COG0297	glycogen (starch) synthase activity
ZPR_RS21405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ZPR_RS21410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ZPR_RS21425	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ZPR_RS21445	COG0667	Aldo Keto reductase
ZPR_RS21450	COG1360	Flagellar Motor Protein
ZPR_RS21455	COG0708	Exodeoxyribonuclease III
ZPR_RS21465	COG2738	Putative neutral zinc metallopeptidase
ZPR_RS21470	COG0528	UMP kinase activity
ZPR_RS21475	COG0233	cytoplasmic translational termination
ZPR_RS21490	COG0017	Asparaginyl-tRNA synthetase
ZPR_RS21495	COG0564	pseudouridine synthase activity
ZPR_RS21500	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZPR_RS21520	COG0848	biopolymer transport protein
ZPR_RS21530	COG0811	peptide transport
ZPR_RS21540	COG0252	asparaginase activity
ZPR_RS21550	COG0084	hydrolase, TatD family'
ZPR_RS21560	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZPR_RS21565	COG0567	Dehydrogenase, E1 component
ZPR_RS21575	COG1309	transcriptional regulator
ZPR_RS21600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZPR_RS21620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZPR_RS21635	COG3590	peptidase
ZPR_RS21645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ZPR_RS21650	COG0792	nuclease activity
ZPR_RS21660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZPR_RS21660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZPR_RS21665	COG0038	chloride channel
ZPR_RS21680	COG0123	including yeast histone deacetylase and acetoin utilization protein
ZPR_RS21690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ZPR_RS21695	COG0629	single-stranded DNA binding
ZPR_RS21730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZPR_RS21775	COG0517	IMP dehydrogenase activity
ZPR_RS21775	COG0617	tRNA 3'-terminal CCA addition
ZPR_RS21775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ZPR_RS21790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZPR_RS21800	COG1028	Short-chain dehydrogenase reductase Sdr
ZPR_RS21805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZPR_RS21820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ZPR_RS21830	COG1573	uracil-dna glycosylase
ZPR_RS21835	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZPR_RS21845	COG1435	thymidine kinase activity
ZPR_RS21850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZPR_RS21855	COG1970	mechanosensitive ion channel activity
ZPR_RS21860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZPR_RS21865	COG1505	serine-type exopeptidase activity
ZPR_RS21870	COG3842	ATPase activity
ZPR_RS21885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZPR_RS21895	COG0439	Biotin carboxylase
ZPR_RS21900	COG0511	ligase activity, forming carbon-carbon bonds
ZPR_RS21905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZPR_RS21910	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ZPR_RS21920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZPR_RS21925	COG0307	riboflavin synthase, alpha
ZPR_RS21930	COG4191	Histidine kinase
ZPR_RS21935	COG2204	response regulator
ZPR_RS21945	COG1136	(ABC) transporter
ZPR_RS21955	COG0577	efflux transmembrane transporter activity
ZPR_RS21960	COG0577	efflux transmembrane transporter activity
ZPR_RS21965	COG1136	(ABC) transporter
ZPR_RS21965	COG0577	efflux transmembrane transporter activity
ZPR_RS21980	COG1136	(ABC) transporter
ZPR_RS21980	COG0577	efflux transmembrane transporter activity
ZPR_RS21985	COG0577	efflux transmembrane transporter activity
ZPR_RS21990	COG1136	(ABC) transporter
ZPR_RS21990	COG0577	efflux transmembrane transporter activity
ZPR_RS21995	COG0577	efflux transmembrane transporter activity
ZPR_RS22005	COG1136	(ABC) transporter
ZPR_RS22005	COG0577	efflux transmembrane transporter activity
ZPR_RS22040	COG0702	epimerase
ZPR_RS22045	COG4771	TonB-dependent receptor
ZPR_RS22050	COG3292	Two component regulator propeller
ZPR_RS22050	COG0745	RESPONSE REGULATOR receiver
ZPR_RS22050	COG2205	protein histidine kinase activity
ZPR_RS22055	COG1629	transport
ZPR_RS22065	COG0673	inositol 2-dehydrogenase activity
ZPR_RS22085	COG0702	epimerase
ZPR_RS22090	COG1629	transport
ZPR_RS22105	COG3279	Response regulator of the LytR AlgR family
ZPR_RS22140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ZPR_RS22155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ZPR_RS22165	COG3541	Predicted nucleotidyltransferase
ZPR_RS22170	COG3279	Response regulator of the LytR AlgR family
ZPR_RS22175	COG3275	phosphorelay sensor kinase activity
ZPR_RS22195	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZPR_RS22215	COG0346	lactoylglutathione lyase activity
ZPR_RS22220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZPR_RS22225	COG4591	ABC-type transport system involved in lipoprotein release permease component
ZPR_RS22245	COG1472	Belongs to the glycosyl hydrolase 3 family
ZPR_RS22255	COG1940	carbohydrate kinase activity
ZPR_RS22260	COG0363	glucosamine-6-phosphate deaminase activity
ZPR_RS22275	COG2801	Transposase and inactivated derivatives
ZPR_RS22280	COG4771	TonB-dependent receptor
ZPR_RS22285	COG0405	Gamma-glutamyltransferase
ZPR_RS22290	COG0791	NLP P60 protein
ZPR_RS22295	COG4948	Mandelate Racemase Muconate Lactonizing
ZPR_RS22300	COG1649	PFAM Uncharacterised BCR, COG1649
ZPR_RS22315	COG1629	transport
ZPR_RS22320	COG2801	Transposase and inactivated derivatives
ZPR_RS22335	COG1629	transport
ZPR_RS22340	COG1349	DNA-binding transcription factor activity
ZPR_RS22345	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZPR_RS22380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS22405	COG1054	Belongs to the UPF0176 family
ZPR_RS22435	COG1216	Glycosyl transferase, family 2
ZPR_RS22435	COG0463	Glycosyl transferase, family 2
ZPR_RS22440	COG1215	transferase activity, transferring glycosyl groups
ZPR_RS22535	COG3437	response regulator, receiver
ZPR_RS22535	COG3850	Histidine kinase
ZPR_RS22535	COG4999	Histidine kinase
ZPR_RS22535	COG2205	protein histidine kinase activity
ZPR_RS22550	COG2356	endonuclease I
ZPR_RS22555	COG0584	glycerophosphoryl diester phosphodiesterase
ZPR_RS22645	COG0667	Aldo Keto reductase
ZPR_RS22660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZPR_RS22665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZPR_RS22700	COG2373	Large extracellular alpha-helical protein
ZPR_RS22745	COG3275	phosphorelay sensor kinase activity
ZPR_RS22765	COG0732	type I restriction modification DNA specificity domain