locus-tag	class	description
INR75_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
INR75_RS00010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INR75_RS00025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
INR75_RS00035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
INR75_RS00040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
INR75_RS00060	COG0336	Belongs to the RNA methyltransferase TrmD family
INR75_RS00065	COG0335	large ribosomal subunit rRNA binding
INR75_RS00075	COG2814	Major facilitator Superfamily
INR75_RS00110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
INR75_RS00115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
INR75_RS00120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
INR75_RS00125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
INR75_RS00135	COG1404	Belongs to the peptidase S8 family
INR75_RS00140	COG1054	Belongs to the UPF0176 family
INR75_RS00145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INR75_RS00155	COG0778	Nitroreductase
INR75_RS00160	COG2353	YceI-like domain
INR75_RS00165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INR75_RS00170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INR75_RS00170	COG0512	Glutamine amidotransferase of anthranilate synthase
INR75_RS00175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
INR75_RS00180	COG0134	indole-3-glycerol-phosphate synthase activity
INR75_RS00185	COG0135	phosphoribosylanthranilate isomerase activity
INR75_RS00190	COG0133	tryptophan synthase activity
INR75_RS00195	COG0159	tryptophan synthase activity
INR75_RS00220	COG3022	response to hydroperoxide
INR75_RS00225	COG0564	pseudouridine synthase activity
INR75_RS00235	COG1181	Belongs to the D-alanine--D-alanine ligase family
INR75_RS00245	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
INR75_RS00275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
INR75_RS00285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
INR75_RS00285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
INR75_RS00290	COG0799	negative regulation of ribosome biogenesis
INR75_RS00295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INR75_RS00305	COG4589	Belongs to the CDS family
INR75_RS00310	COG0688	phosphatidylethanolamine metabolic process
INR75_RS00320	COG0525	valine-tRNA ligase activity
INR75_RS00330	COG0436	Aminotransferase
INR75_RS00335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
INR75_RS00360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
INR75_RS00365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INR75_RS00375	COG1663	tetraacyldisaccharide 4'-kinase activity
INR75_RS00380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
INR75_RS00400	COG3263	regulation of cellular component size
INR75_RS00405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
INR75_RS00425	COG0415	Belongs to the DNA photolyase family
INR75_RS00430	COG3046	protein related to deoxyribodipyrimidine photolyase
INR75_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS00455	COG3844	kynureninase activity
INR75_RS00465	COG0671	phosphoesterase, PA-phosphatase related
INR75_RS00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INR75_RS00505	COG3340	Belongs to the peptidase S51 family
INR75_RS00510	COG2066	Belongs to the glutaminase family
INR75_RS00515	COG0268	Binds directly to 16S ribosomal RNA
INR75_RS00530	COG0442	prolyl-tRNA aminoacylation
INR75_RS00550	COG0302	gtp cyclohydrolase
INR75_RS00555	COG0215	cysteine-tRNA ligase activity
INR75_RS00560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
INR75_RS00565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INR75_RS00585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
INR75_RS00595	COG0187	DNA topoisomerase II activity
INR75_RS00605	COG0602	queuosine metabolic process
INR75_RS00615	COG4771	TonB-dependent receptor
INR75_RS00625	COG1619	proteins homologs of microcin C7 resistance protein MccF
INR75_RS00660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INR75_RS00665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
INR75_RS00675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
INR75_RS00680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
INR75_RS00685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
INR75_RS00700	COG0275	rRNA processing
INR75_RS00705	COG2001	Belongs to the MraZ family
INR75_RS00710	COG2267	carboxylic ester hydrolase activity
INR75_RS00715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
INR75_RS00735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
INR75_RS00740	COG2197	response regulator
INR75_RS00745	COG0358	DNA primase activity
INR75_RS00765	COG1187	pseudouridine synthase activity
INR75_RS00785	COG3339	Conserved Protein
INR75_RS00800	COG1053	succinate dehydrogenase
INR75_RS00805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
INR75_RS00810	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
INR75_RS00815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
INR75_RS00820	COG0018	arginyl-trna synthetase
INR75_RS00830	COG2095	MarC family integral membrane protein
INR75_RS00845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
INR75_RS00870	COG0148	phosphopyruvate hydratase activity
INR75_RS00880	COG0203	ribosomal protein L17
INR75_RS00885	COG0202	RNA polymerase activity
INR75_RS00890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
INR75_RS00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
INR75_RS00900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
INR75_RS00905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
INR75_RS00910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
INR75_RS00920	COG0200	Binds to the 23S rRNA
INR75_RS00925	COG1841	ribosomal large subunit assembly
INR75_RS00930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
INR75_RS00935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
INR75_RS00940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
INR75_RS00945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
INR75_RS00950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
INR75_RS00955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
INR75_RS00960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
INR75_RS00965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
INR75_RS00970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
INR75_RS00975	COG0255	Belongs to the universal ribosomal protein uL29 family
INR75_RS00980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
INR75_RS00985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
INR75_RS00990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
INR75_RS00995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
INR75_RS01000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
INR75_RS01005	COG0089	rRNA binding
INR75_RS01010	COG0088	Forms part of the polypeptide exit tunnel
INR75_RS01015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
INR75_RS01020	COG0051	transcription antitermination factor activity, RNA binding
INR75_RS01025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
INR75_RS01030	COG0049	tRNA binding
INR75_RS01035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
INR75_RS01040	COG4206	TonB-dependent receptor
INR75_RS01040	COG1629	transport
INR75_RS01050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INR75_RS01060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
INR75_RS01080	COG2003	Belongs to the UPF0758 family
INR75_RS01085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
INR75_RS01120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
INR75_RS01135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
INR75_RS01140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
INR75_RS01145	COG0339	signal peptide processing
INR75_RS01165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INR75_RS01165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
INR75_RS01170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INR75_RS01210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
INR75_RS01215	COG1127	ABC transporter
INR75_RS01230	COG0300	oxidoreductase activity
INR75_RS01240	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_RS01245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
INR75_RS01250	COG0295	cytidine deaminase activity
INR75_RS01260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_RS01265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
INR75_RS01280	COG0285	dihydrofolate synthase activity
INR75_RS01290	COG0848	biopolymer transport protein
INR75_RS01295	COG0811	peptide transport
INR75_RS01300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INR75_RS01310	COG1960	acyl-CoA dehydrogenase activity
INR75_RS01315	COG0070	glutamate synthase
INR75_RS01315	COG0069	glutamate synthase activity
INR75_RS01315	COG0067	glutamate synthase
INR75_RS01360	COG1629	transport
INR75_RS01365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
INR75_RS01370	COG0702	epimerase
INR75_RS01375	COG4771	TonB-dependent receptor
INR75_RS01380	COG0702	epimerase
INR75_RS01390	COG4771	TonB-dependent receptor
INR75_RS01395	COG0321	lipoyl(octanoyl) transferase activity
INR75_RS01400	COG0401	homolog of Blt101
INR75_RS01405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
INR75_RS01420	COG0701	Predicted permease
INR75_RS01425	COG2217	Heavy metal translocating P-type atpase
INR75_RS01435	COG4977	sequence-specific DNA binding
INR75_RS01435	COG1917	Cupin 2, conserved barrel domain protein
INR75_RS01490	COG0138	bifunctional purine biosynthesis protein purh
INR75_RS01495	COG1077	Cell shape determining protein MreB Mrl
INR75_RS01510	COG0768	penicillin binding
INR75_RS01515	COG0772	Belongs to the SEDS family
INR75_RS01530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
INR75_RS01540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS01545	COG0791	NLP P60 protein
INR75_RS01550	COG2333	competence protein COMEC
INR75_RS01550	COG0658	competence protein
INR75_RS01560	COG3104	oligopeptide transport
INR75_RS01565	COG0823	Involved in the tonB-independent uptake of proteins
INR75_RS01565	COG1506	peptidase
INR75_RS01585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INR75_RS01590	COG1253	flavin adenine dinucleotide binding
INR75_RS01600	COG0457	Tetratricopeptide repeat
INR75_RS01610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
INR75_RS01630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INR75_RS01635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_RS01640	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_RS01650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
INR75_RS01660	COG0544	peptidyl-prolyl cis-trans isomerase activity
INR75_RS01680	COG0596	Alpha beta hydrolase
INR75_RS01685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
INR75_RS01695	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
INR75_RS01705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
INR75_RS01710	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
INR75_RS01725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
INR75_RS01745	COG1331	Highly conserved protein containing a thioredoxin domain
INR75_RS01750	COG0668	transmembrane transport
INR75_RS01755	COG1214	PFAM Peptidase M22, glycoprotease
INR75_RS01770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_RS01775	COG0577	efflux transmembrane transporter activity
INR75_RS01775	COG1136	(ABC) transporter
INR75_RS01780	COG0577	efflux transmembrane transporter activity
INR75_RS01780	COG1136	(ABC) transporter
INR75_RS01785	COG1136	(ABC) transporter
INR75_RS01795	COG2322	membrane
INR75_RS01800	COG1999	signal sequence binding
INR75_RS01815	COG1845	cytochrome c oxidase, subunit III
INR75_RS01820	COG1845	cytochrome c oxidase, subunit III
INR75_RS01825	COG0109	protoheme IX farnesyltransferase activity
INR75_RS01845	COG0509	glycine decarboxylation via glycine cleavage system
INR75_RS01855	COG0632	four-way junction helicase activity
INR75_RS01860	COG0281	malic enzyme
INR75_RS01860	COG0280	phosphate acetyltransferase
INR75_RS01865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
INR75_RS01870	COG2124	cytochrome p450
INR75_RS01875	COG2255	four-way junction helicase activity
INR75_RS01880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
INR75_RS01905	COG0052	Belongs to the universal ribosomal protein uS2 family
INR75_RS01910	COG0437	4 iron, 4 sulfur cluster binding
INR75_RS01915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
INR75_RS01915	COG2010	Cytochrome c
INR75_RS01925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
INR75_RS01930	COG0195	Participates in both transcription termination and antitermination
INR75_RS01930	COG2251	uridine kinase activity
INR75_RS01935	COG0779	Required for maturation of 30S ribosomal subunits
INR75_RS01940	COG0589	response to stress
INR75_RS01980	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
INR75_RS01985	COG0438	transferase activity, transferring glycosyl groups
INR75_RS02005	COG0110	maltose O-acetyltransferase activity
INR75_RS02055	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
INR75_RS02060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_RS02065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
INR75_RS02070	COG1218	3'(2'),5'-bisphosphate nucleotidase
INR75_RS02080	COG0175	sulfate reduction
INR75_RS02085	COG0529	Catalyzes the synthesis of activated sulfate
INR75_RS02090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
INR75_RS02090	COG0662	Cupin 2, conserved barrel domain protein
INR75_RS02140	COG1629	transport
INR75_RS02150	COG3273	potassium ion transport
INR75_RS02150	COG0471	metal ion transport
INR75_RS02180	COG1446	asparaginase
INR75_RS02190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INR75_RS02190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
INR75_RS02195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
INR75_RS02200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
INR75_RS02205	COG0052	Belongs to the universal ribosomal protein uS2 family
INR75_RS02210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
INR75_RS02215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
INR75_RS02240	COG0492	ferredoxin-NADP+ reductase activity
INR75_RS02250	COG0489	protein tyrosine kinase activity
INR75_RS02265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INR75_RS02275	COG5002	protein histidine kinase activity
INR75_RS02280	COG0745	RESPONSE REGULATOR receiver
INR75_RS02285	COG4771	TonB-dependent receptor
INR75_RS02305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
INR75_RS02320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INR75_RS02325	COG0463	Glycosyl transferase, family 2
INR75_RS02340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INR75_RS02345	COG2363	Small membrane protein
INR75_RS02355	COG1522	sequence-specific DNA binding
INR75_RS02365	COG1528	Iron-storage protein
INR75_RS02370	COG0423	glycine-tRNA ligase activity
INR75_RS02410	COG1201	RNA secondary structure unwinding
INR75_RS02415	COG1793	dna ligase
INR75_RS02430	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
INR75_RS02445	COG0460	homoserine dehydrogenase
INR75_RS02445	COG0527	aspartate kinase activity
INR75_RS02455	COG0702	epimerase
INR75_RS02460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
INR75_RS02470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INR75_RS02475	COG2239	Acts as a magnesium transporter
INR75_RS02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
INR75_RS02500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
INR75_RS02510	COG0196	riboflavin kinase activity
INR75_RS02515	COG0193	aminoacyl-tRNA hydrolase activity
INR75_RS02520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
INR75_RS02525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INR75_RS02545	COG4585	Histidine kinase
INR75_RS02570	COG0793	Belongs to the peptidase S41A family
INR75_RS02590	COG2095	MarC family integral membrane protein
INR75_RS02600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
INR75_RS02610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INR75_RS02615	COG0590	tRNA wobble adenosine to inosine editing
INR75_RS02665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INR75_RS02670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
INR75_RS02675	COG3720	iron ion transport
INR75_RS02990	COG0745	RESPONSE REGULATOR receiver
INR75_RS02990	COG2205	protein histidine kinase activity
INR75_RS02990	COG3292	Two component regulator propeller
INR75_RS02995	COG4206	TonB-dependent receptor
INR75_RS02995	COG1629	transport
INR75_RS03000	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INR75_RS03010	COG3867	Arabinogalactan endo-beta-1,4-galactanase
INR75_RS03015	COG3250	beta-galactosidase activity
INR75_RS03025	COG4974	Belongs to the 'phage' integrase family
INR75_RS03045	COG2942	2-epimerase
INR75_RS03050	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INR75_RS03065	COG2207	Transcriptional regulator
INR75_RS03070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INR75_RS03075	COG4771	TonB-dependent receptor
INR75_RS03080	COG0702	epimerase
INR75_RS03095	COG3345	alpha-galactosidase
INR75_RS03100	COG2942	2-epimerase
INR75_RS03120	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS03130	COG4771	TonB-dependent receptor
INR75_RS03175	COG0583	DNA-binding transcription factor activity
INR75_RS03180	COG0753	catalase activity
INR75_RS03205	COG2003	Belongs to the UPF0758 family
INR75_RS03210	COG0629	single-stranded DNA binding
INR75_RS03220	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS03275	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS03285	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS03295	COG2382	esterase
INR75_RS03295	COG3693	PFAM glycoside hydrolase, family 10
INR75_RS03300	COG2382	esterase
INR75_RS03300	COG3693	PFAM glycoside hydrolase, family 10
INR75_RS03305	COG2382	esterase
INR75_RS03310	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS03320	COG1609	Transcriptional regulator
INR75_RS03325	COG0702	epimerase
INR75_RS03330	COG4771	TonB-dependent receptor
INR75_RS03405	COG0702	epimerase
INR75_RS03410	COG1629	transport
INR75_RS03440	COG4974	Belongs to the 'phage' integrase family
INR75_RS03485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INR75_RS03490	COG0626	cystathionine gamma-synthase activity
INR75_RS03515	COG0429	hydrolase of the alpha beta-hydrolase fold
INR75_RS03520	COG1561	YicC-like family, N-terminal region
INR75_RS03525	COG0194	GDP metabolic process
INR75_RS03530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
INR75_RS03535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
INR75_RS03555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
INR75_RS03580	COG0288	reversible hydration of carbon dioxide
INR75_RS03585	COG0659	secondary active sulfate transmembrane transporter activity
INR75_RS03615	COG2304	oxidoreductase activity
INR75_RS03630	COG0714	Associated with various cellular activities
INR75_RS03640	COG4221	oxidoreductase activity
INR75_RS03660	COG3339	Conserved Protein
INR75_RS03665	COG0793	Belongs to the peptidase S41A family
INR75_RS03730	COG0662	Cupin 2, conserved barrel domain protein
INR75_RS03735	COG1446	asparaginase
INR75_RS03750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_RS03765	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
INR75_RS03770	COG3118	belongs to the thioredoxin family
INR75_RS03780	COG2954	triphosphatase activity
INR75_RS03790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
INR75_RS03805	COG0571	ribonuclease III activity
INR75_RS03810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INR75_RS03815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
INR75_RS03820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INR75_RS03825	COG0328	RNA-DNA hybrid ribonuclease activity
INR75_RS03835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
INR75_RS03845	COG1074	ATP-dependent DNA helicase activity
INR75_RS03850	COG0156	8-amino-7-oxononanoate synthase activity
INR75_RS03885	COG0534	Mate efflux family protein
INR75_RS03925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INR75_RS03930	COG2022	thiamine diphosphate biosynthetic process
INR75_RS03935	COG0352	thiamine-phosphate diphosphorylase activity
INR75_RS03945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
INR75_RS03955	COG0720	synthase
INR75_RS03965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS03980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
INR75_RS03980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
INR75_RS03990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
INR75_RS04000	COG1573	uracil-dna glycosylase
INR75_RS04005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
INR75_RS04015	COG1435	thymidine kinase activity
INR75_RS04020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
INR75_RS04025	COG1970	mechanosensitive ion channel activity
INR75_RS04030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
INR75_RS04035	COG1505	serine-type exopeptidase activity
INR75_RS04050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
INR75_RS04060	COG0439	Biotin carboxylase
INR75_RS04065	COG0511	ligase activity, forming carbon-carbon bonds
INR75_RS04070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INR75_RS04075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
INR75_RS04085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
INR75_RS04090	COG0307	riboflavin synthase, alpha
INR75_RS04105	COG2204	response regulator
INR75_RS04115	COG0577	efflux transmembrane transporter activity
INR75_RS04115	COG1136	(ABC) transporter
INR75_RS04135	COG0577	efflux transmembrane transporter activity
INR75_RS04135	COG1136	(ABC) transporter
INR75_RS04145	COG0577	efflux transmembrane transporter activity
INR75_RS04145	COG1136	(ABC) transporter
INR75_RS04160	COG3250	beta-galactosidase activity
INR75_RS04175	COG3250	beta-galactosidase activity
INR75_RS04190	COG0702	epimerase
INR75_RS04195	COG4771	TonB-dependent receptor
INR75_RS04200	COG2205	protein histidine kinase activity
INR75_RS04200	COG0745	RESPONSE REGULATOR receiver
INR75_RS04200	COG3292	Two component regulator propeller
INR75_RS04215	COG0346	lactoylglutathione lyase activity
INR75_RS04220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
INR75_RS04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
INR75_RS04240	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS04250	COG1940	carbohydrate kinase activity
INR75_RS04250	COG1846	Transcriptional regulator
INR75_RS04255	COG0363	glucosamine-6-phosphate deaminase activity
INR75_RS04265	COG0791	NLP P60 protein
INR75_RS04270	COG4948	Mandelate Racemase Muconate Lactonizing
INR75_RS04275	COG1649	PFAM Uncharacterised BCR, COG1649
INR75_RS04285	COG1629	transport
INR75_RS04290	COG1349	DNA-binding transcription factor activity
INR75_RS04295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
INR75_RS04300	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INR75_RS04310	COG0481	GTPase activity
INR75_RS04320	COG0217	transcriptional regulatory protein
INR75_RS04325	COG3263	regulation of cellular component size
INR75_RS04330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_RS04345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INR75_RS04350	COG0594	ribonuclease P activity
INR75_RS04355	COG0793	Belongs to the peptidase S41A family
INR75_RS04360	COG2153	protein acetylation
INR75_RS04365	COG0698	ribose 5-phosphate isomerase
INR75_RS04375	COG0557	exoribonuclease II activity
INR75_RS04395	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
INR75_RS04400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INR75_RS04420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
INR75_RS04430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
INR75_RS04435	COG0445	tRNA wobble uridine modification
INR75_RS04460	COG0470	DNA polymerase III
INR75_RS04465	COG0126	phosphoglycerate kinase activity
INR75_RS04470	COG3942	CHAP domain
INR75_RS04470	COG1388	LysM domain
INR75_RS04480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
INR75_RS04485	COG0739	heme binding
INR75_RS04500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_RS04505	COG1215	transferase activity, transferring glycosyl groups
INR75_RS04515	COG0151	Belongs to the GarS family
INR75_RS04540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
INR75_RS04575	COG0356	it plays a direct role in the translocation of protons across the membrane
INR75_RS04580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INR75_RS04585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
INR75_RS04590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
INR75_RS04595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
INR75_RS04600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
INR75_RS04615	COG0756	dUTP diphosphatase activity
INR75_RS04620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
INR75_RS04650	COG1607	acyl-coa hydrolase
INR75_RS04660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INR75_RS04660	COG0758	DNA mediated transformation
INR75_RS04665	COG0180	Tryptophanyl-tRNA synthetase
INR75_RS04700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
INR75_RS04705	COG0826	peptidase U32
INR75_RS04715	COG1054	Belongs to the UPF0176 family
INR75_RS04720	COG1774	PSP1 C-terminal conserved region
INR75_RS04730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INR75_RS04735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
INR75_RS04780	COG0113	porphobilinogen synthase activity
INR75_RS04790	COG0408	coproporphyrinogen oxidase activity
INR75_RS04805	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
INR75_RS04820	COG0181	hydroxymethylbilane synthase activity
INR75_RS04825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
INR75_RS04840	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
INR75_RS04850	COG1981	membrane
INR75_RS04860	COG1024	Enoyl-CoA hydratase
INR75_RS04875	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
INR75_RS04885	COG1418	mRNA catabolic process
INR75_RS04890	COG0204	Acyl-transferase
INR75_RS04905	COG0484	heat shock protein binding
INR75_RS04925	COG4771	TonB-dependent receptor
INR75_RS04930	COG1321	iron dependent repressor
INR75_RS04930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
INR75_RS04960	COG1999	signal sequence binding
INR75_RS04965	COG0750	zinc metalloprotease
INR75_RS04975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INR75_RS04980	COG1621	beta-fructofuranosidase activity
INR75_RS04995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
INR75_RS05000	COG1335	isochorismatase
INR75_RS05020	COG1381	Involved in DNA repair and RecF pathway recombination
INR75_RS05080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
INR75_RS05095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INR75_RS05100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
INR75_RS05110	COG0189	ligase activity
INR75_RS05120	COG0322	excinuclease ABC activity
INR75_RS05125	COG1752	Esterase of the alpha-beta hydrolase superfamily
INR75_RS05135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
INR75_RS05140	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
INR75_RS05145	COG3185	4-Hydroxyphenylpyruvate dioxygenase
INR75_RS05155	COG3483	tryptophan 2,3-dioxygenase activity
INR75_RS05165	COG0166	Belongs to the GPI family
INR75_RS05170	COG4771	TonB-dependent receptor
INR75_RS05180	COG2356	endonuclease I
INR75_RS05215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
INR75_RS05230	COG2151	metal-sulfur cluster biosynthetic enzyme
INR75_RS05235	COG2166	iron-sulfur cluster assembly
INR75_RS05245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
INR75_RS05250	COG0719	Fe-S assembly protein
INR75_RS05255	COG0396	ATPase activity
INR75_RS05265	COG0719	Fe-S assembly protein
INR75_RS05275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
INR75_RS05290	COG0006	proline dipeptidase activity
INR75_RS05295	COG0367	asparagine synthase
INR75_RS05305	COG1053	succinate dehydrogenase
INR75_RS05315	COG0436	Aminotransferase
INR75_RS05335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS05350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
INR75_RS05365	COG0517	IMP dehydrogenase activity
INR75_RS05375	COG3773	Cell wall hydrolase
INR75_RS05375	COG3409	Peptidoglycan-binding domain 1 protein
INR75_RS05410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INR75_RS05445	COG0629	single-stranded DNA binding
INR75_RS05450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
INR75_RS05465	COG0123	including yeast histone deacetylase and acetoin utilization protein
INR75_RS05470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INR75_RS05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INR75_RS05480	COG0792	nuclease activity
INR75_RS05490	COG3590	peptidase
INR75_RS05505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_RS05535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
INR75_RS05560	COG1309	transcriptional regulator
INR75_RS05570	COG0567	Dehydrogenase, E1 component
INR75_RS05575	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_RS05585	COG0084	hydrolase, TatD family'
INR75_RS05595	COG0252	asparaginase activity
INR75_RS05605	COG0811	peptide transport
INR75_RS05615	COG0848	biopolymer transport protein
INR75_RS05635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
INR75_RS05640	COG0564	pseudouridine synthase activity
INR75_RS05650	COG0017	Asparaginyl-tRNA synthetase
INR75_RS05665	COG0233	cytoplasmic translational termination
INR75_RS05670	COG0528	UMP kinase activity
INR75_RS05675	COG2738	Putative neutral zinc metallopeptidase
INR75_RS05685	COG0708	Exodeoxyribonuclease III
INR75_RS05690	COG1360	Flagellar Motor Protein
INR75_RS05695	COG0667	Aldo Keto reductase
INR75_RS05705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
INR75_RS05720	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
INR75_RS05725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
INR75_RS05730	COG0297	glycogen (starch) synthase activity
INR75_RS05740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
INR75_RS05745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
INR75_RS05750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
INR75_RS05760	COG3655	Transcriptional regulator
INR75_RS05775	COG2111	Na H antiporter
INR75_RS05775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
INR75_RS05780	COG2111	Na H antiporter
INR75_RS05785	COG1006	Multisubunit Na H antiporter MnhC subunit
INR75_RS05790	COG0651	ATP synthesis coupled electron transport
INR75_RS05795	COG1863	multisubunit Na H antiporter MnhE subunit
INR75_RS05800	COG2212	antiporter activity
INR75_RS05805	COG1320	monovalent cation:proton antiporter activity
INR75_RS05810	COG0156	8-amino-7-oxononanoate synthase activity
INR75_RS05820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
INR75_RS05825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
INR75_RS05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INR75_RS05835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
INR75_RS05850	COG2137	regulation of response to DNA damage stimulus
INR75_RS05865	COG1530	ribonuclease E activity
INR75_RS05870	COG0776	regulation of translation
INR75_RS05880	COG0629	single-stranded DNA binding
INR75_RS05900	COG0612	Peptidase, M16
INR75_RS05905	COG0612	Peptidase, M16
INR75_RS05915	COG0261	This protein binds to 23S rRNA in the presence of protein L20
INR75_RS05920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
INR75_RS05935	COG1629	transport
INR75_RS05960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
INR75_RS05970	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
INR75_RS05975	COG0702	epimerase
INR75_RS05980	COG1733	regulation of RNA biosynthetic process
INR75_RS06000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INR75_RS06030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INR75_RS06045	COG2205	protein histidine kinase activity
INR75_RS06050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
INR75_RS06060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
INR75_RS06070	COG0519	Catalyzes the synthesis of GMP from XMP
INR75_RS06085	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
INR75_RS06090	COG1968	undecaprenyl-diphosphatase activity
INR75_RS06100	COG2177	Part of the ABC transporter FtsEX involved in
INR75_RS06105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
INR75_RS06110	COG0495	leucyl-tRNA aminoacylation
INR75_RS06115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
INR75_RS06120	COG0228	four-way junction DNA binding
INR75_RS06135	COG3118	belongs to the thioredoxin family
INR75_RS06150	COG4974	Belongs to the 'phage' integrase family
INR75_RS06155	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
INR75_RS06235	COG4771	TonB-dependent receptor
INR75_RS06265	COG3360	Dodecin
INR75_RS06280	COG3685	Protein conserved in bacteria
INR75_RS06285	COG2124	cytochrome p450
INR75_RS06295	COG3177	Filamentation induced by cAMP protein fic
INR75_RS06305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
INR75_RS06310	COG1522	sequence-specific DNA binding
INR75_RS06335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_RS06375	COG4221	oxidoreductase activity
INR75_RS06385	COG1607	acyl-coa hydrolase
INR75_RS06410	COG2072	flavoprotein involved in K transport
INR75_RS06420	COG1380	Effector of murein hydrolase LrgA
INR75_RS06425	COG1346	cytolysis
INR75_RS06435	COG5002	protein histidine kinase activity
INR75_RS06435	COG0784	Response regulator, receiver
INR75_RS06435	COG2198	Histidine kinase
INR75_RS06495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
INR75_RS06500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INR75_RS06520	COG2315	Protein conserved in bacteria
INR75_RS06525	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INR75_RS06540	COG0739	heme binding
INR75_RS06545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INR75_RS06765	COG4712	double-strand break repair protein
INR75_RS06790	COG2197	response regulator
INR75_RS06865	COG0861	Integral membrane protein TerC family
INR75_RS06880	COG2323	membrane
INR75_RS06885	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS06895	COG2081	HI0933 family
INR75_RS06900	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
INR75_RS06920	COG1187	pseudouridine synthase activity
INR75_RS06930	COG0010	Belongs to the arginase family
INR75_RS06955	COG1215	transferase activity, transferring glycosyl groups
INR75_RS06960	COG0463	Glycosyl transferase, family 2
INR75_RS06970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
INR75_RS06990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
INR75_RS07015	COG3279	Response regulator of the LytR AlgR family
INR75_RS07035	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INR75_RS07055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
INR75_RS07065	COG1629	transport
INR75_RS07080	COG4771	TonB-dependent receptor
INR75_RS07115	COG0471	metal ion transport
INR75_RS07160	COG3142	Participates in the control of copper homeostasis
INR75_RS07170	COG0459	protein refolding
INR75_RS07175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
INR75_RS07200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INR75_RS07205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
INR75_RS07205	COG1754	DNA topoisomerase type I activity
INR75_RS07215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_RS07245	COG0488	(ABC) transporter
INR75_RS07250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_RS07275	COG4771	TonB-dependent receptor
INR75_RS07285	COG1629	transport
INR75_RS07285	COG4206	TonB-dependent receptor
INR75_RS07290	COG0702	epimerase
INR75_RS07310	COG2205	protein histidine kinase activity
INR75_RS07310	COG3292	Two component regulator propeller
INR75_RS07310	COG0745	RESPONSE REGULATOR receiver
INR75_RS07330	COG0798	PFAM Bile acid sodium symporter
INR75_RS07360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
INR75_RS07365	COG1349	DNA-binding transcription factor activity
INR75_RS07380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
INR75_RS07390	COG0386	Belongs to the glutathione peroxidase family
INR75_RS07395	COG1846	Transcriptional regulator
INR75_RS07420	COG0659	secondary active sulfate transmembrane transporter activity
INR75_RS07425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
INR75_RS07430	COG1160	GTP binding
INR75_RS07460	COG0739	heme binding
INR75_RS07465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
INR75_RS07500	COG2515	1-aminocyclopropane-1-carboxylate deaminase
INR75_RS07510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
INR75_RS07525	COG0110	maltose O-acetyltransferase activity
INR75_RS07540	COG1428	Deoxynucleoside kinase
INR75_RS07550	COG0823	Involved in the tonB-independent uptake of proteins
INR75_RS07560	COG0657	acetylesterase activity
INR75_RS07560	COG2755	lipolytic protein G-D-S-L family
INR75_RS07565	COG1119	ATPase activity
INR75_RS07570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
INR75_RS07600	COG0347	Belongs to the P(II) protein family
INR75_RS07635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_RS07640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INR75_RS07650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
INR75_RS07665	COG0531	amino acid
INR75_RS07690	COG0723	plastoquinol--plastocyanin reductase activity
INR75_RS07780	COG1917	Cupin 2, conserved barrel domain protein
INR75_RS07780	COG2207	Transcriptional regulator
INR75_RS07785	COG4716	Myosin-crossreactive antigen
INR75_RS07790	COG1024	Enoyl-CoA hydratase
INR75_RS07790	COG1250	3-hydroxyacyl-CoA dehydrogenase
INR75_RS07825	COG4372	Transposase
INR75_RS07845	COG4974	Belongs to the 'phage' integrase family
INR75_RS07855	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
INR75_RS07895	COG4771	TonB-dependent receptor
INR75_RS07900	COG0702	epimerase
INR75_RS07940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
INR75_RS07940	COG1519	Transferase
INR75_RS07965	COG1629	transport
INR75_RS07970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
INR75_RS08005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_RS08025	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
INR75_RS08030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
INR75_RS08040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
INR75_RS08050	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_RS08050	COG0022	dehydrogenase e1 component
INR75_RS08060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
INR75_RS08065	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
INR75_RS08085	COG1428	Deoxynucleoside kinase
INR75_RS08090	COG2207	Transcriptional regulator
INR75_RS08095	COG1012	belongs to the aldehyde dehydrogenase family
INR75_RS08115	COG0471	metal ion transport
INR75_RS08115	COG3273	potassium ion transport
INR75_RS08135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INR75_RS08145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INR75_RS08150	COG1960	acyl-CoA dehydrogenase activity
INR75_RS08170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
INR75_RS08180	COG1959	2 iron, 2 sulfur cluster binding
INR75_RS08190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
INR75_RS08200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
INR75_RS08200	COG1648	precorrin-2 dehydrogenase activity
INR75_RS08205	COG0492	ferredoxin-NADP+ reductase activity
INR75_RS08210	COG1765	OsmC-like protein
INR75_RS08225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
INR75_RS08230	COG0527	aspartate kinase activity
INR75_RS08230	COG0460	homoserine dehydrogenase
INR75_RS08245	COG1605	Chorismate mutase
INR75_RS08245	COG0077	Prephenate dehydratase
INR75_RS08250	COG0436	Aminotransferase
INR75_RS08255	COG0287	Prephenate dehydrogenase
INR75_RS08260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
INR75_RS08265	COG1162	GTPase activity
INR75_RS08270	COG1490	D-aminoacyl-tRNA deacylase activity
INR75_RS08295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
INR75_RS08300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
INR75_RS08305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
INR75_RS08340	COG4771	TonB-dependent receptor
INR75_RS08345	COG0702	epimerase
INR75_RS08360	COG3119	arylsulfatase activity
INR75_RS08365	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS08375	COG1610	YqeY-like protein
INR75_RS08485	COG0156	8-amino-7-oxononanoate synthase activity
INR75_RS08515	COG4771	TonB-dependent receptor
INR75_RS08530	COG4974	Belongs to the 'phage' integrase family
INR75_RS08540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INR75_RS08565	COG1051	belongs to the nudix hydrolase family
INR75_RS08570	COG0135	phosphoribosylanthranilate isomerase activity
INR75_RS08595	COG0798	PFAM Bile acid sodium symporter
INR75_RS08640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
INR75_RS08645	COG0604	alcohol dehydrogenase
INR75_RS08645	COG3321	synthase
INR75_RS08765	COG0737	Belongs to the 5'-nucleotidase family
INR75_RS08770	COG0737	Belongs to the 5'-nucleotidase family
INR75_RS08780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INR75_RS08805	COG0497	DNA recombination
INR75_RS08810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
INR75_RS08825	COG0237	dephospho-CoA kinase activity
INR75_RS08840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
INR75_RS08845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
INR75_RS08860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
INR75_RS08870	COG1250	3-hydroxyacyl-CoA dehydrogenase
INR75_RS08880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
INR75_RS08885	COG2234	aminopeptidase activity
INR75_RS08905	COG2354	Protein conserved in bacteria
INR75_RS08915	COG0745	RESPONSE REGULATOR receiver
INR75_RS08975	COG0584	glycerophosphoryl diester phosphodiesterase
INR75_RS08980	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
INR75_RS08985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_RS08995	COG2755	lipolytic protein G-D-S-L family
INR75_RS09015	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS09020	COG4771	TonB-dependent receptor
INR75_RS09025	COG0702	epimerase
INR75_RS09050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
INR75_RS09060	COG3781	membrane
INR75_RS09075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
INR75_RS09080	COG1917	Cupin 2, conserved barrel domain protein
INR75_RS09080	COG2169	Transcriptional regulator
INR75_RS09120	COG4771	TonB-dependent receptor
INR75_RS09125	COG0702	epimerase
INR75_RS09130	COG3250	beta-galactosidase activity
INR75_RS09140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS09140	COG3952	Lipid A Biosynthesis
INR75_RS09145	COG1215	transferase activity, transferring glycosyl groups
INR75_RS09150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_RS09155	COG1703	isobutyryl-CoA mutase activity
INR75_RS09160	COG1764	response to oxidative stress
INR75_RS09205	COG0653	protein targeting
INR75_RS09225	COG1136	(ABC) transporter
INR75_RS09245	COG0488	(ABC) transporter
INR75_RS09255	COG0489	protein tyrosine kinase activity
INR75_RS09290	COG0463	Glycosyl transferase, family 2
INR75_RS09290	COG1216	Glycosyl transferase, family 2
INR75_RS09330	COG1083	cytidylyl-transferase
INR75_RS09340	COG2089	acid synthase
INR75_RS09365	COG2813	Specifically methylates the guanine in position
INR75_RS09375	COG0438	transferase activity, transferring glycosyl groups
INR75_RS09385	COG0438	transferase activity, transferring glycosyl groups
INR75_RS09390	COG0438	transferase activity, transferring glycosyl groups
INR75_RS09395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INR75_RS09400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
INR75_RS09410	COG1137	ATPase activity
INR75_RS09420	COG0805	protein transport
INR75_RS09425	COG0517	IMP dehydrogenase activity
INR75_RS09425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
INR75_RS09430	COG0514	ATP-dependent DNA helicase (RecQ)
INR75_RS09455	COG3876	Protein conserved in bacteria
INR75_RS09460	COG0577	efflux transmembrane transporter activity
INR75_RS09475	COG1115	amino acid carrier protein
INR75_RS09515	COG1115	amino acid carrier protein
INR75_RS09525	COG1960	acyl-CoA dehydrogenase activity
INR75_RS09530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
INR75_RS09535	COG4974	Belongs to the 'phage' integrase family
INR75_RS09565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
INR75_RS09585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
INR75_RS09590	COG0081	regulation of translation
INR75_RS09595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
INR75_RS09600	COG0222	ribosome binding
INR75_RS09605	COG0085	RNA polymerase activity
INR75_RS09610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
INR75_RS09625	COG1115	amino acid carrier protein
INR75_RS09630	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
INR75_RS09635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
INR75_RS09655	COG0579	oxidoreductase
INR75_RS09670	COG0561	phosphatase activity
INR75_RS09710	COG2198	Histidine kinase
INR75_RS09710	COG0784	Response regulator, receiver
INR75_RS09710	COG5002	protein histidine kinase activity
INR75_RS09720	COG0326	Molecular chaperone. Has ATPase activity
INR75_RS09735	COG1506	peptidase
INR75_RS09740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
INR75_RS09770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
INR75_RS09795	COG4181	ATPase activity
INR75_RS09845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
INR75_RS09865	COG1473	amidohydrolase
INR75_RS09880	COG0009	L-threonylcarbamoyladenylate synthase
INR75_RS09890	COG1360	Flagellar Motor Protein
INR75_RS09895	COG0463	Glycosyl transferase, family 2
INR75_RS09910	COG1575	Belongs to the MenA family. Type 1 subfamily
INR75_RS09915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INR75_RS09925	COG4948	Mandelate Racemase Muconate Lactonizing
INR75_RS09930	COG1266	CAAX protease self-immunity
INR75_RS09970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INR75_RS09985	COG0488	(ABC) transporter
INR75_RS09990	COG2197	response regulator
INR75_RS09995	COG4585	Histidine kinase
INR75_RS10005	COG0071	Belongs to the small heat shock protein (HSP20) family
INR75_RS10025	COG0534	Mate efflux family protein
INR75_RS10035	COG0671	phosphoesterase, PA-phosphatase related
INR75_RS10040	COG4771	TonB-dependent receptor
INR75_RS10045	COG0702	epimerase
INR75_RS10060	COG1312	Catalyzes the dehydration of D-mannonate
INR75_RS10070	COG3661	Belongs to the glycosyl hydrolase 67 family
INR75_RS10075	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS10080	COG1904	glucuronate isomerase
INR75_RS10090	COG0800	Aldolase
INR75_RS10095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
INR75_RS10110	COG1609	Transcriptional regulator
INR75_RS10145	COG0477	Major facilitator Superfamily
INR75_RS10145	COG2814	Major facilitator Superfamily
INR75_RS10170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_RS10170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INR75_RS10175	COG1262	PFAM Formylglycine-generating sulfatase enzyme
INR75_RS10185	COG2115	Belongs to the xylose isomerase family
INR75_RS10195	COG2080	2 iron, 2 sulfur cluster binding
INR75_RS10200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
INR75_RS10205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
INR75_RS10210	COG0303	'Molybdopterin
INR75_RS10235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
INR75_RS10240	COG0746	molybdenum cofactor guanylyltransferase activity
INR75_RS10245	COG0315	cyclic pyranopterin monophosphate synthase activity
INR75_RS10250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
INR75_RS10255	COG0314	molybdopterin synthase activity
INR75_RS10265	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
INR75_RS10280	COG1312	Catalyzes the dehydration of D-mannonate
INR75_RS10285	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS10290	COG3401	FG-GAP repeat protein
INR75_RS10295	COG3250	beta-galactosidase activity
INR75_RS10300	COG2755	lipolytic protein G-D-S-L family
INR75_RS10310	COG2755	lipolytic protein G-D-S-L family
INR75_RS10315	COG3254	rhamnose metabolic process
INR75_RS10330	COG1501	Belongs to the glycosyl hydrolase 31 family
INR75_RS10350	COG1629	transport
INR75_RS10370	COG4771	TonB-dependent receptor
INR75_RS10385	COG0702	epimerase
INR75_RS10390	COG4771	TonB-dependent receptor
INR75_RS10405	COG1304	FMN binding
INR75_RS10415	COG4952	isomerase
INR75_RS10420	COG3347	Dehydrogenase
INR75_RS10420	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS10425	COG2188	Transcriptional regulator
INR75_RS10430	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
INR75_RS10435	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS10440	COG1904	glucuronate isomerase
INR75_RS10450	COG0800	Aldolase
INR75_RS10460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
INR75_RS10470	COG0246	Mannitol dehydrogenase
INR75_RS10475	COG2721	sulfolactate sulfo-lyase activity
INR75_RS10500	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_RS10505	COG0657	acetylesterase activity
INR75_RS10515	COG2755	lipolytic protein G-D-S-L family
INR75_RS10540	COG3940	Belongs to the glycosyl hydrolase 43 family
INR75_RS10545	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_RS10600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
INR75_RS10640	COG1064	alcohol dehydrogenase
INR75_RS10645	COG1064	alcohol dehydrogenase
INR75_RS10695	COG1942	4-Oxalocrotonate Tautomerase
INR75_RS10700	COG0673	inositol 2-dehydrogenase activity
INR75_RS10705	COG0656	L-ascorbic acid biosynthetic process
INR75_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS10725	COG2814	Major facilitator Superfamily
INR75_RS10730	COG0702	epimerase
INR75_RS10735	COG0640	Transcriptional regulator
INR75_RS10750	COG0702	epimerase
INR75_RS10755	COG3250	beta-galactosidase activity
INR75_RS10760	COG0612	Peptidase, M16
INR75_RS10770	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
INR75_RS10775	COG0076	glutamate decarboxylase activity
INR75_RS10785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
INR75_RS10785	COG0519	Catalyzes the synthesis of GMP from XMP
INR75_RS10815	COG0482	sulfurtransferase activity
INR75_RS10830	COG0706	membrane insertase activity
INR75_RS10835	COG0504	CTP synthase activity
INR75_RS10840	COG3530	Putative quorum-sensing-regulated virulence factor
INR75_RS10845	COG2201	protein-glutamate methylesterase activity
INR75_RS10900	COG0494	nUDIX hydrolase
INR75_RS10910	COG0516	GMP reductase activity
INR75_RS10920	COG0019	diaminopimelate decarboxylase activity
INR75_RS10925	COG2814	Major facilitator Superfamily
INR75_RS10930	COG0045	succinate-CoA ligase (ADP-forming) activity
INR75_RS10940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INR75_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS10975	COG1064	alcohol dehydrogenase
INR75_RS10980	COG0028	Belongs to the TPP enzyme family
INR75_RS10985	COG0626	cystathionine gamma-synthase activity
INR75_RS10990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
INR75_RS11005	COG3956	TIGRFAM MazG family protein
INR75_RS11010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
INR75_RS11020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
INR75_RS11040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INR75_RS11060	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
INR75_RS11070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
INR75_RS11075	COG0501	Belongs to the peptidase M48B family
INR75_RS11080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
INR75_RS11090	COG0804	urea catabolic process
INR75_RS11105	COG2195	Cleaves the N-terminal amino acid of tripeptides
INR75_RS11120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INR75_RS11130	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INR75_RS11140	COG0105	UTP biosynthetic process
INR75_RS11155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
INR75_RS11165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
INR75_RS11175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
INR75_RS11200	COG0681	Belongs to the peptidase S26 family
INR75_RS11205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
INR75_RS11215	COG1475	DNA binding
INR75_RS11220	COG1192	Involved in chromosome partitioning
INR75_RS11225	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS11230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_RS11230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_RS11235	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_RS11245	COG0572	uridine kinase
INR75_RS11255	COG2133	pyrroloquinoline quinone binding
INR75_RS11265	COG4974	Belongs to the 'phage' integrase family
INR75_RS11285	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
INR75_RS11365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
INR75_RS11445	COG4974	Belongs to the 'phage' integrase family
INR75_RS11475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
INR75_RS11575	COG4974	Belongs to the 'phage' integrase family
INR75_RS11580	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
INR75_RS11590	COG0592	DNA-directed DNA polymerase activity
INR75_RS11615	COG1702	phosphate starvation-inducible protein PhoH
INR75_RS11620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
INR75_RS11625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
INR75_RS11630	COG2176	DNA-directed DNA polymerase activity
INR75_RS11655	COG1363	Peptidase, m42
INR75_RS11700	COG0116	Belongs to the methyltransferase superfamily
INR75_RS11715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
INR75_RS11720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INR75_RS11755	COG1104	cysteine desulfurase activity
INR75_RS11780	COG1418	mRNA catabolic process
INR75_RS11785	COG0656	L-ascorbic acid biosynthetic process
INR75_RS11790	COG4974	Belongs to the 'phage' integrase family
INR75_RS11800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
INR75_RS11815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_RS11825	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INR75_RS11830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INR75_RS11845	COG2270	Major facilitator Superfamily
INR75_RS11870	COG1595	DNA-templated transcription, initiation
INR75_RS11875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
INR75_RS11880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
INR75_RS11885	COG2814	Major facilitator Superfamily
INR75_RS11890	COG0539	negative regulation of cytoplasmic translation
INR75_RS11900	COG2198	Histidine kinase
INR75_RS11900	COG0784	Response regulator, receiver
INR75_RS11900	COG0643	Histidine kinase
INR75_RS11905	COG5002	protein histidine kinase activity
INR75_RS11945	COG0346	lactoylglutathione lyase activity
INR75_RS11950	COG4302	ethanolamine ammonia-lyase activity
INR75_RS11955	COG4303	Ethanolamine ammonia lyase large subunit
INR75_RS11960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
INR75_RS11970	COG0667	Aldo Keto reductase
INR75_RS11980	COG1764	response to oxidative stress
INR75_RS11985	COG1846	Transcriptional regulator
INR75_RS11995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
INR75_RS12005	COG1335	isochorismatase
INR75_RS12010	COG0668	transmembrane transport
INR75_RS12020	COG1082	Xylose isomerase domain protein TIM barrel
INR75_RS12025	COG0590	tRNA wobble adenosine to inosine editing
INR75_RS12035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INR75_RS12040	COG0540	Belongs to the ATCase OTCase family
INR75_RS12050	COG1234	tRNA 3'-trailer cleavage
INR75_RS12055	COG0259	pyridoxamine-phosphate oxidase activity
INR75_RS12060	COG0494	nUDIX hydrolase
INR75_RS12060	COG0406	alpha-ribazole phosphatase activity
INR75_RS12065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INR75_RS12080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
INR75_RS12095	COG0742	ribosomal rna small subunit methyltransferase
INR75_RS12115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
INR75_RS12120	COG0415	Belongs to the DNA photolyase family
INR75_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS12155	COG0668	transmembrane transport
INR75_RS12165	COG0424	maF-like protein
INR75_RS12185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
INR75_RS12185	COG1333	cytochrome c biogenesis protein
INR75_RS12210	COG1393	Belongs to the ArsC family
INR75_RS12215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
INR75_RS12230	COG2308	Evidence 4 Homologs of previously reported genes of
INR75_RS12250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
INR75_RS12265	COG0156	8-amino-7-oxononanoate synthase activity
INR75_RS12300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INR75_RS12310	COG0655	NAD(P)H dehydrogenase (quinone) activity
INR75_RS12315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
INR75_RS12320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
INR75_RS12330	COG0686	Belongs to the AlaDH PNT family
INR75_RS12345	COG0802	atpase or kinase
INR75_RS12350	COG2204	response regulator
INR75_RS12355	COG1078	dGTPase activity
INR75_RS12360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS12365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INR75_RS12365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
INR75_RS12370	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS12375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
INR75_RS12380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS12400	COG0612	Peptidase, M16
INR75_RS12405	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS12420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
INR75_RS12425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
INR75_RS12435	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INR75_RS12440	COG0131	Imidazoleglycerol-phosphate dehydratase
INR75_RS12445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
INR75_RS12455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
INR75_RS12460	COG0107	imidazoleglycerol-phosphate synthase activity
INR75_RS12465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
INR75_RS12465	COG0140	phosphoribosyl-ATP diphosphatase activity
INR75_RS12480	COG1741	Belongs to the pirin family
INR75_RS12510	COG0101	tRNA pseudouridine synthase activity
INR75_RS12515	COG0514	ATP-dependent DNA helicase (RecQ)
INR75_RS12520	COG0598	Magnesium transport protein CorA
INR75_RS12525	COG2706	6-phosphogluconolactonase activity
INR75_RS12540	COG0189	ligase activity
INR75_RS12560	COG0745	RESPONSE REGULATOR receiver
INR75_RS12570	COG0545	Peptidyl-prolyl cis-trans isomerase
INR75_RS12585	COG2814	Major facilitator Superfamily
INR75_RS12590	COG2217	Heavy metal translocating P-type atpase
INR75_RS12605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
INR75_RS12615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
INR75_RS12635	COG1830	Aldolase
INR75_RS12645	COG0531	amino acid
INR75_RS12690	COG3385	transposase activity
INR75_RS12700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
INR75_RS12760	COG2132	Multicopper oxidase
INR75_RS12765	COG0531	amino acid
INR75_RS12800	COG0069	glutamate synthase activity
INR75_RS12860	COG0347	Belongs to the P(II) protein family
INR75_RS12950	COG0629	single-stranded DNA binding
INR75_RS12955	COG2003	Belongs to the UPF0758 family
INR75_RS13075	COG0668	transmembrane transport
INR75_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS13090	COG1764	response to oxidative stress
INR75_RS13095	COG1846	Transcriptional regulator
INR75_RS13110	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
INR75_RS13125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_RS13130	COG1309	transcriptional regulator
INR75_RS13145	COG3321	synthase
INR75_RS13145	COG0604	alcohol dehydrogenase
INR75_RS13170	COG0463	Glycosyl transferase, family 2
INR75_RS13175	COG3952	Lipid A Biosynthesis
INR75_RS13175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
INR75_RS13190	COG0745	RESPONSE REGULATOR receiver
INR75_RS13195	COG0642	Histidine kinase
INR75_RS13205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS13210	COG1477	protein flavinylation
INR75_RS13245	COG2207	Transcriptional regulator
INR75_RS13250	COG4771	TonB-dependent receptor
INR75_RS13255	COG0702	epimerase
INR75_RS13270	COG4124	Belongs to the glycosyl hydrolase 26 family
INR75_RS13275	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
INR75_RS13325	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS13370	COG1678	Uncharacterized ACR, COG1678
INR75_RS13380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
INR75_RS13385	COG0514	ATP-dependent DNA helicase (RecQ)
INR75_RS13405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
INR75_RS13420	COG4774	siderophore transport
INR75_RS13430	COG0321	lipoyl(octanoyl) transferase activity
INR75_RS13430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
INR75_RS13460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
INR75_RS13465	COG0280	phosphate acetyltransferase
INR75_RS13465	COG0857	belongs to the CobB CobQ family
INR75_RS13490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
INR75_RS13500	COG2205	protein histidine kinase activity
INR75_RS13510	COG1136	(ABC) transporter
INR75_RS13515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
INR75_RS13530	COG4771	TonB-dependent receptor
INR75_RS13555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
INR75_RS13560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
INR75_RS13570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
INR75_RS13590	COG1629	transport
INR75_RS13595	COG0702	epimerase
INR75_RS13600	COG3534	alpha-L-arabinofuranosidase
INR75_RS13605	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS13620	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS13625	COG3940	Belongs to the glycosyl hydrolase 43 family
INR75_RS13635	COG0235	Class ii aldolase
INR75_RS13640	COG2160	L-arabinose isomerase activity
INR75_RS13710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
INR75_RS13745	COG4206	TonB-dependent receptor
INR75_RS13745	COG1629	transport
INR75_RS13760	COG2076	Multidrug Resistance protein
INR75_RS13765	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS13770	COG2205	protein histidine kinase activity
INR75_RS13770	COG0745	RESPONSE REGULATOR receiver
INR75_RS13770	COG3292	Two component regulator propeller
INR75_RS13775	COG4771	TonB-dependent receptor
INR75_RS13780	COG0702	epimerase
INR75_RS13790	COG3250	beta-galactosidase activity
INR75_RS13800	COG1501	Belongs to the glycosyl hydrolase 31 family
INR75_RS13805	COG1082	Xylose isomerase domain protein TIM barrel
INR75_RS13810	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS13815	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS13825	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
INR75_RS13835	COG1482	cell wall glycoprotein biosynthetic process
INR75_RS13870	COG2311	Membrane
INR75_RS13890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS13935	COG0006	proline dipeptidase activity
INR75_RS13940	COG3250	beta-galactosidase activity
INR75_RS13945	COG0823	Involved in the tonB-independent uptake of proteins
INR75_RS13945	COG1506	peptidase
INR75_RS13955	COG4948	Mandelate Racemase Muconate Lactonizing
INR75_RS13960	COG4771	TonB-dependent receptor
INR75_RS13970	COG1629	transport
INR75_RS13990	COG4977	sequence-specific DNA binding
INR75_RS13990	COG1917	Cupin 2, conserved barrel domain protein
INR75_RS13995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
INR75_RS14005	COG3938	Belongs to the proline racemase family
INR75_RS14015	COG1506	peptidase
INR75_RS14015	COG0823	Involved in the tonB-independent uptake of proteins
INR75_RS14030	COG3534	alpha-L-arabinofuranosidase
INR75_RS14085	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS14100	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS14145	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS14160	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS14175	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS14215	COG2826	transposase and inactivated derivatives, IS30 family
INR75_RS14230	COG4974	Belongs to the 'phage' integrase family
INR75_RS14235	COG1473	amidohydrolase
INR75_RS14245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
INR75_RS14275	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
INR75_RS14285	COG1764	response to oxidative stress
INR75_RS14290	COG1047	Peptidyl-prolyl cis-trans
INR75_RS14295	COG0673	inositol 2-dehydrogenase activity
INR75_RS14320	COG0527	aspartate kinase activity
INR75_RS14335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
INR75_RS14340	COG3265	gluconokinase activity
INR75_RS14345	COG2610	gluconate transmembrane transporter activity
INR75_RS14355	COG0217	transcriptional regulatory protein
INR75_RS14360	COG2154	pterin-4-alpha-carbinolamine dehydratase
INR75_RS14370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
INR75_RS14375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
INR75_RS14375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
INR75_RS14380	COG2986	histidine ammonia-lyase
INR75_RS14390	COG0542	response to heat
INR75_RS14395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
INR75_RS14410	COG0183	Belongs to the thiolase family
INR75_RS14440	COG1012	belongs to the aldehyde dehydrogenase family
INR75_RS14455	COG1607	acyl-coa hydrolase
INR75_RS14460	COG0668	transmembrane transport
INR75_RS14470	COG0668	transmembrane transport
INR75_RS14475	COG2814	Major facilitator Superfamily
INR75_RS14505	COG4221	oxidoreductase activity
INR75_RS14520	COG4221	oxidoreductase activity
INR75_RS14525	COG2130	NADP-dependent
INR75_RS14530	COG1289	transmembrane transporter activity
INR75_RS14550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
INR75_RS14560	COG1902	pentaerythritol trinitrate reductase activity
INR75_RS14570	COG0604	alcohol dehydrogenase
INR75_RS14590	COG0583	DNA-binding transcription factor activity
INR75_RS14595	COG2855	membrane
INR75_RS14600	COG0698	ribose 5-phosphate isomerase
INR75_RS14605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
INR75_RS14610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
INR75_RS14615	COG0363	glucosamine-6-phosphate deaminase activity
INR75_RS14625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
INR75_RS14630	COG3384	dioxygenase
INR75_RS14640	COG2723	6-phospho-beta-galactosidase activity
INR75_RS14655	COG1629	transport
INR75_RS14715	COG0022	dehydrogenase e1 component
INR75_RS14725	COG0023	Translation Initiation Factor
INR75_RS14735	COG0813	purine-nucleoside phosphorylase activity
INR75_RS14740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
INR75_RS14745	COG1054	Belongs to the UPF0176 family
INR75_RS14755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
INR75_RS14765	COG3011	Protein conserved in bacteria
INR75_RS14780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
INR75_RS14805	COG0778	Nitroreductase
INR75_RS14820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
INR75_RS14830	COG0693	protein deglycase activity
INR75_RS14835	COG1295	ribonuclease BN
INR75_RS14845	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
INR75_RS14850	COG1522	sequence-specific DNA binding
INR75_RS14875	COG1970	mechanosensitive ion channel activity
INR75_RS14895	COG0012	GTP binding
INR75_RS14905	COG2226	methyltransferase
INR75_RS14915	COG3537	Alpha-1,2-mannosidase
INR75_RS14920	COG3537	Alpha-1,2-mannosidase
INR75_RS14950	COG0247	lactate metabolic process
INR75_RS14960	COG0438	transferase activity, transferring glycosyl groups
INR75_RS14965	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS14975	COG0247	lactate metabolic process
INR75_RS14975	COG2181	nitrate reductase activity
INR75_RS14980	COG0247	lactate metabolic process
INR75_RS14980	COG2181	nitrate reductase activity
INR75_RS14990	COG0860	N-Acetylmuramoyl-L-alanine amidase
INR75_RS15000	COG0251	oxidation-reduction process
INR75_RS15005	COG0667	Aldo Keto reductase
INR75_RS15015	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
INR75_RS15025	COG1803	Methylglyoxal synthase
INR75_RS15030	COG0205	6-phosphofructokinase activity
INR75_RS15040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
INR75_RS15055	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
INR75_RS15095	COG1215	transferase activity, transferring glycosyl groups
INR75_RS15100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INR75_RS15105	COG0038	chloride channel
INR75_RS15115	COG0726	polysaccharide deacetylase
INR75_RS15125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
INR75_RS15150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
INR75_RS15160	COG1028	Short-chain dehydrogenase reductase Sdr
INR75_RS15185	COG4974	Belongs to the 'phage' integrase family
INR75_RS15260	COG0805	protein transport
INR75_RS15265	COG2963	transposase activity
INR75_RS15275	COG0681	Belongs to the peptidase S26 family
INR75_RS15280	COG3279	Response regulator of the LytR AlgR family
INR75_RS15285	COG3275	phosphorelay sensor kinase activity
INR75_RS15295	COG5002	protein histidine kinase activity
INR75_RS15300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INR75_RS15335	COG0667	Aldo Keto reductase
INR75_RS15340	COG0124	histidyl-tRNA synthetase
INR75_RS15345	COG0577	efflux transmembrane transporter activity
INR75_RS15360	COG0359	binds to the 23S rRNA
INR75_RS15365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
INR75_RS15370	COG0360	Binds together with S18 to 16S ribosomal RNA
INR75_RS15375	COG3279	Response regulator of the LytR AlgR family
INR75_RS15380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
INR75_RS15395	COG1295	ribonuclease BN
INR75_RS15405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
INR75_RS15410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
INR75_RS15435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
INR75_RS15450	COG0670	Belongs to the BI1 family
INR75_RS15455	COG1091	dTDP-4-dehydrorhamnose reductase activity
INR75_RS15505	COG1842	Phage shock protein A
INR75_RS15535	COG0589	response to stress
INR75_RS15540	COG0069	glutamate synthase activity
INR75_RS15545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
INR75_RS15555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
INR75_RS15605	COG1045	serine acetyltransferase
INR75_RS15615	COG2936	dipeptidyl-peptidase activity
INR75_RS15625	COG4771	TonB-dependent receptor
INR75_RS15680	COG4206	TonB-dependent receptor
INR75_RS15690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
INR75_RS15695	COG1120	ATPase activity
INR75_RS15715	COG1607	acyl-coa hydrolase
INR75_RS15730	COG2363	Small membrane protein
INR75_RS15740	COG0230	Belongs to the bacterial ribosomal protein bL34 family
INR75_RS15765	COG1741	Belongs to the pirin family
INR75_RS15775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INR75_RS15800	COG0254	rRNA binding
INR75_RS15810	COG0463	Glycosyl transferase, family 2
INR75_RS15815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INR75_RS15820	COG1132	(ABC) transporter
INR75_RS15845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
INR75_RS15845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INR75_RS15850	COG0047	phosphoribosylformylglycinamidine synthase activity
INR75_RS15850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
INR75_RS15865	COG1022	Amp-dependent synthetase and ligase
INR75_RS15870	COG1846	Transcriptional regulator
INR75_RS15875	COG1024	Enoyl-CoA hydratase
INR75_RS15875	COG1250	3-hydroxyacyl-CoA dehydrogenase
INR75_RS15885	COG0183	Belongs to the thiolase family
INR75_RS15890	COG1960	acyl-CoA dehydrogenase activity
INR75_RS15910	COG3387	PFAM Glycoside hydrolase 15-related
INR75_RS15945	COG2183	response to ionizing radiation
INR75_RS15960	COG4771	TonB-dependent receptor
INR75_RS15965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INR75_RS16005	COG2211	Major facilitator Superfamily
INR75_RS16010	COG0673	inositol 2-dehydrogenase activity
INR75_RS16030	COG1595	DNA-templated transcription, initiation
INR75_RS16040	COG3279	Response regulator of the LytR AlgR family
INR75_RS16050	COG3275	phosphorelay sensor kinase activity
INR75_RS16060	COG1629	transport
INR75_RS16060	COG4206	TonB-dependent receptor
INR75_RS16085	COG0494	nUDIX hydrolase
INR75_RS16090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INR75_RS16120	COG0714	Associated with various cellular activities
INR75_RS16185	COG0492	ferredoxin-NADP+ reductase activity
INR75_RS16190	COG2860	membrane
INR75_RS16210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
INR75_RS16215	COG0439	Biotin carboxylase
INR75_RS16225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_RS16265	COG1476	TRANSCRIPTIONal
INR75_RS16270	COG3940	Belongs to the glycosyl hydrolase 43 family
INR75_RS16280	COG1271	oxidase subunit
INR75_RS16285	COG0730	response to heat
INR75_RS16305	COG1733	regulation of RNA biosynthetic process
INR75_RS16320	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
INR75_RS16325	COG0352	thiamine-phosphate diphosphorylase activity
INR75_RS16330	COG0351	phosphomethylpyrimidine kinase
INR75_RS16335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
INR75_RS16345	COG2207	Transcriptional regulator
INR75_RS16360	COG1785	Belongs to the alkaline phosphatase family
INR75_RS16365	COG1785	Belongs to the alkaline phosphatase family
INR75_RS16375	COG4206	TonB-dependent receptor
INR75_RS16375	COG1629	transport
INR75_RS16410	COG3279	Response regulator of the LytR AlgR family
INR75_RS16440	COG0714	Associated with various cellular activities
INR75_RS16450	COG0312	modulator of DNA gyrase
INR75_RS16455	COG0312	modulator of DNA gyrase
INR75_RS16505	COG0348	domain, Protein
INR75_RS16520	COG3278	Belongs to the heme-copper respiratory oxidase family
INR75_RS16530	COG2217	Heavy metal translocating P-type atpase
INR75_RS16560	COG2205	protein histidine kinase activity
INR75_RS16560	COG3437	response regulator, receiver
INR75_RS16560	COG3850	Histidine kinase
INR75_RS16560	COG4999	Histidine kinase
INR75_RS16565	COG2116	formate transmembrane transporter activity
INR75_RS16570	COG2084	Dehydrogenase
INR75_RS16585	COG0339	signal peptide processing
INR75_RS16600	COG1187	pseudouridine synthase activity
INR75_RS16610	COG0405	Gamma-glutamyltransferase
INR75_RS16625	COG4251	negative regulation of phosphorylation
INR75_RS16635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INR75_RS16640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
INR75_RS16645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
INR75_RS16655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
INR75_RS16655	COG4651	solute:proton antiporter activity
INR75_RS16685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
INR75_RS16690	COG0083	homoserine kinase activity
INR75_RS16695	COG0527	aspartate kinase activity
INR75_RS16695	COG0460	homoserine dehydrogenase
INR75_RS16715	COG3437	response regulator, receiver
INR75_RS16735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
INR75_RS16740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
INR75_RS16745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
INR75_RS16750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_RS16765	COG0783	Belongs to the Dps family
INR75_RS16770	COG0668	transmembrane transport
INR75_RS16800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS16820	COG1715	Restriction endonuclease
INR75_RS16825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
INR75_RS16835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
INR75_RS16840	COG1611	Belongs to the LOG family
INR75_RS16850	COG0022	dehydrogenase e1 component
INR75_RS16905	COG2996	Protein conserved in bacteria
INR75_RS16915	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
INR75_RS16945	COG0443	Heat shock 70 kDa protein
INR75_RS16950	COG1760	l-serine dehydratase
INR75_RS16970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
INR75_RS16990	COG3387	PFAM Glycoside hydrolase 15-related
INR75_RS17005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
INR75_RS17010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
INR75_RS17015	COG0066	3-isopropylmalate dehydratase activity
INR75_RS17020	COG0473	3-isopropylmalate dehydrogenase activity
INR75_RS17030	COG0165	Argininosuccinate lyase
INR75_RS17035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
INR75_RS17040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
INR75_RS17050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
INR75_RS17055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
INR75_RS17060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
INR75_RS17065	COG0137	argininosuccinate synthase activity
INR75_RS17075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
INR75_RS17080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
INR75_RS17090	COG0028	Belongs to the TPP enzyme family
INR75_RS17100	COG3153	acetyltransferase
INR75_RS17100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
INR75_RS17110	COG4585	Histidine kinase
INR75_RS17130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
INR75_RS17135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
INR75_RS17140	COG1914	H( )-stimulated, divalent metal cation uptake system
INR75_RS17195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
INR75_RS17200	COG0205	6-phosphofructokinase activity
INR75_RS17205	COG0366	Alpha amylase catalytic
INR75_RS17210	COG0366	Alpha amylase catalytic
INR75_RS17215	COG1082	Xylose isomerase domain protein TIM barrel
INR75_RS17220	COG1554	hydrolase, family 65, central catalytic
INR75_RS17225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
INR75_RS17240	COG4206	TonB-dependent receptor
INR75_RS17240	COG1629	transport
INR75_RS17245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
INR75_RS17255	COG0366	Alpha amylase catalytic
INR75_RS17285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
INR75_RS17290	COG1085	galactose-1-phosphate uridylyltransferase
INR75_RS17315	COG4232	protein-disulfide reductase activity
INR75_RS17320	COG0037	tRNA processing
INR75_RS17325	COG3549	Plasmid maintenance system killer
INR75_RS17335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
INR75_RS17365	COG3279	Response regulator of the LytR AlgR family
INR75_RS17385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
INR75_RS17390	COG1757	Na H antiporter
INR75_RS17395	COG0450	alkyl hydroperoxide reductase
INR75_RS17425	COG1674	ftsk spoiiie
INR75_RS17440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INR75_RS17440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
INR75_RS17465	COG4771	TonB-dependent receptor
INR75_RS17470	COG0561	phosphatase activity
INR75_RS17490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
INR75_RS17495	COG0420	3'-5' exonuclease activity
INR75_RS17500	COG0419	ATPase involved in DNA repair
INR75_RS17510	COG1272	protein, Hemolysin III
INR75_RS17515	COG2197	response regulator
INR75_RS17580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
INR75_RS17660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS17690	COG0386	Belongs to the glutathione peroxidase family
INR75_RS17700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
INR75_RS17715	COG3507	Belongs to the glycosyl hydrolase 43 family
INR75_RS17750	COG0242	peptide deformylase activity
INR75_RS17780	COG4974	Belongs to the 'phage' integrase family
INR75_RS17790	COG1012	belongs to the aldehyde dehydrogenase family
INR75_RS17795	COG0656	L-ascorbic acid biosynthetic process
INR75_RS17815	COG1368	sulfuric ester hydrolase activity
INR75_RS17830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
INR75_RS17845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INR75_RS17860	COG0154	amidase activity
INR75_RS17865	COG0552	protein localization to endoplasmic reticulum
INR75_RS17875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
INR75_RS17880	COG0227	Belongs to the bacterial ribosomal protein bL28 family
INR75_RS17885	COG1058	Belongs to the CinA family
INR75_RS17885	COG1546	Belongs to the CinA family
INR75_RS17895	COG0179	Fumarylacetoacetate (FAA) hydrolase
INR75_RS17905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
INR75_RS17910	COG0508	dehydrogenase complex catalyzes the overall conversion of
INR75_RS17915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
INR75_RS17935	COG0488	(ABC) transporter
INR75_RS17945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
INR75_RS17950	COG0300	oxidoreductase activity
INR75_RS17985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
INR75_RS18000	COG3118	belongs to the thioredoxin family
INR75_RS18005	COG0542	response to heat
INR75_RS18025	COG1012	belongs to the aldehyde dehydrogenase family
INR75_RS18035	COG4106	trans-aconitate 2-methyltransferase activity
INR75_RS18045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
INR75_RS18060	COG0242	peptide deformylase activity
INR75_RS18065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
INR75_RS18070	COG2171	N-acyltransferase activity
INR75_RS18100	COG0009	L-threonylcarbamoyladenylate synthase
INR75_RS18105	COG0517	IMP dehydrogenase activity
INR75_RS18105	COG0617	tRNA 3'-terminal CCA addition
INR75_RS18105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
INR75_RS18145	COG0556	nucleotide-excision repair
INR75_RS18155	COG2204	response regulator
INR75_RS18165	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
INR75_RS18165	COG3264	Mechanosensitive ion channel
INR75_RS18170	COG1668	transmembrane transport
INR75_RS18175	COG4152	abc transporter atp-binding protein
INR75_RS18185	COG0484	heat shock protein binding
INR75_RS18190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
INR75_RS18205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
INR75_RS18205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
INR75_RS18215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
INR75_RS18235	COG0347	Belongs to the P(II) protein family
INR75_RS18240	COG0004	ammonium transporteR
INR75_RS18265	COG2226	methyltransferase
INR75_RS18270	COG1522	sequence-specific DNA binding
INR75_RS18280	COG2095	MarC family integral membrane protein
INR75_RS18285	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_RS18285	COG1703	isobutyryl-CoA mutase activity
INR75_RS18285	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
INR75_RS18290	COG0788	formyltetrahydrofolate deformylase activity
INR75_RS18295	COG0753	catalase activity
INR75_RS18310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
INR75_RS18315	COG0284	orotidine-5'-phosphate decarboxylase activity
INR75_RS18320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
INR75_RS18325	COG1131	(ABC) transporter
INR75_RS18335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
INR75_RS18345	COG0174	glutamine synthetase
INR75_RS18370	COG1629	transport
INR75_RS18370	COG4206	TonB-dependent receptor
INR75_RS18380	COG2814	Major facilitator Superfamily
INR75_RS18385	COG2885	chlorophyll binding
INR75_RS18420	COG1994	Peptidase M50
INR75_RS18445	COG0604	alcohol dehydrogenase
INR75_RS18455	COG3250	beta-galactosidase activity
INR75_RS18470	COG3250	beta-galactosidase activity
INR75_RS18480	COG0702	epimerase
INR75_RS18485	COG1629	transport
INR75_RS18485	COG4206	TonB-dependent receptor
INR75_RS18490	COG0745	RESPONSE REGULATOR receiver
INR75_RS18490	COG3292	Two component regulator propeller
INR75_RS18490	COG2205	protein histidine kinase activity
INR75_RS18495	COG0745	RESPONSE REGULATOR receiver
INR75_RS18495	COG2205	protein histidine kinase activity
INR75_RS18495	COG3292	Two component regulator propeller
INR75_RS18500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
INR75_RS18505	COG1621	beta-fructofuranosidase activity
INR75_RS18520	COG1621	beta-fructofuranosidase activity
INR75_RS18530	COG4771	TonB-dependent receptor
INR75_RS18535	COG1621	beta-fructofuranosidase activity
INR75_RS18540	COG2814	Major facilitator Superfamily
INR75_RS18545	COG3292	Two component regulator propeller
INR75_RS18545	COG2205	protein histidine kinase activity
INR75_RS18545	COG0745	RESPONSE REGULATOR receiver
INR75_RS18550	COG0629	single-stranded DNA binding
INR75_RS18555	COG2003	Belongs to the UPF0758 family
INR75_RS18565	COG2076	Multidrug Resistance protein
INR75_RS18575	COG3852	Histidine kinase
INR75_RS18585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
INR75_RS18610	COG1629	transport
INR75_RS18620	COG3279	Response regulator of the LytR AlgR family
INR75_RS18635	COG2201	protein-glutamate methylesterase activity
INR75_RS18645	COG0629	single-stranded DNA binding
INR75_RS18650	COG2003	Belongs to the UPF0758 family
INR75_RS18750	COG0156	8-amino-7-oxononanoate synthase activity
INR75_RS18775	COG2304	oxidoreductase activity
INR75_RS18840	COG2264	protein methyltransferase activity
INR75_RS18845	COG0149	triose-phosphate isomerase activity
INR75_RS18860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
INR75_RS18865	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
INR75_RS18875	COG1132	(ABC) transporter
INR75_RS18880	COG0101	tRNA pseudouridine synthase activity
INR75_RS18900	COG0745	RESPONSE REGULATOR receiver
INR75_RS18905	COG5002	protein histidine kinase activity
INR75_RS18925	COG0740	serine-type endopeptidase activity
INR75_RS18940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
INR75_RS18965	COG2226	methyltransferase
INR75_RS18970	COG1477	protein flavinylation
INR75_RS18985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INR75_RS18990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INR75_RS19000	COG1805	sodium ion transport
INR75_RS19005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
INR75_RS19030	COG1012	belongs to the aldehyde dehydrogenase family
INR75_RS19040	COG0357	Ribosomal RNA small subunit methyltransferase G
INR75_RS19045	COG3239	Fatty acid desaturase
INR75_RS19050	COG0436	Aminotransferase
INR75_RS19055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INR75_RS19060	COG0569	domain protein
INR75_RS19065	COG2226	methyltransferase
INR75_RS19085	COG0191	fructose-bisphosphate aldolase activity
INR75_RS19090	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
INR75_RS19095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
INR75_RS19100	COG1185	polyribonucleotide nucleotidyltransferase activity
INR75_RS19110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
INR75_RS19120	COG0095	Lipoate-protein ligase
INR75_RS19125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
INR75_RS19130	COG0492	ferredoxin-NADP+ reductase activity
INR75_RS19145	COG2814	Major facilitator Superfamily
INR75_RS19145	COG0477	Major facilitator Superfamily
INR75_RS19185	COG3250	beta-galactosidase activity
INR75_RS19190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
INR75_RS19215	COG0702	epimerase
INR75_RS19220	COG4771	TonB-dependent receptor
INR75_RS19225	COG3292	Two component regulator propeller
INR75_RS19225	COG2205	protein histidine kinase activity
INR75_RS19225	COG0745	RESPONSE REGULATOR receiver
INR75_RS19225	COG3292	Two component regulator propeller
INR75_RS19225	COG0745	RESPONSE REGULATOR receiver
INR75_RS19225	COG2205	protein histidine kinase activity
INR75_RS19230	COG4677	pectinesterase activity
INR75_RS19235	COG0432	Pfam Uncharacterised protein family UPF0047
INR75_RS19245	COG0305	Participates in initiation and elongation during chromosome replication
INR75_RS19250	COG0825	malonyl-CoA metabolic process
INR75_RS19260	COG0343	queuine tRNA-ribosyltransferase activity
INR75_RS19265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
INR75_RS19270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
INR75_RS19285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
INR75_RS19290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
INR75_RS19295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
INR75_RS19320	COG0789	Transcriptional regulator
INR75_RS19325	COG1233	COG1233 Phytoene dehydrogenase and related
INR75_RS19345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS19350	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
INR75_RS19355	COG0714	Associated with various cellular activities
INR75_RS19360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
INR75_RS19375	COG0517	IMP dehydrogenase activity
INR75_RS19375	COG0516	GMP reductase activity
INR75_RS19395	COG0167	dihydroorotate dehydrogenase activity
INR75_RS19400	COG2195	Cleaves the N-terminal amino acid of tripeptides
INR75_RS19420	COG1862	Preprotein translocase
INR75_RS19430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
INR75_RS19440	COG1132	(ABC) transporter
INR75_RS19455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
INR75_RS19460	COG0569	domain protein
INR75_RS19470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
INR75_RS19480	COG0450	alkyl hydroperoxide reductase
INR75_RS19485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
INR75_RS19490	COG1228	amidohydrolase
INR75_RS19510	COG2884	Cell division ATP-binding protein ftsE
INR75_RS19520	COG1858	cytochrome C peroxidase
INR75_RS19545	COG1217	gtp-binding protein TYPA
INR75_RS19555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
INR75_RS19560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS19670	COG3590	peptidase
INR75_RS19790	COG2197	response regulator
INR75_RS19795	COG4585	Histidine kinase
INR75_RS19825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
INR75_RS19900	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
INR75_RS19945	COG2003	Belongs to the UPF0758 family
INR75_RS19950	COG0629	single-stranded DNA binding
INR75_RS19955	COG0783	Belongs to the Dps family
INR75_RS19965	COG0450	alkyl hydroperoxide reductase
INR75_RS19995	COG0737	Belongs to the 5'-nucleotidase family
INR75_RS20010	COG1271	oxidase subunit
INR75_RS20035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
INR75_RS20070	COG2814	Major facilitator Superfamily
INR75_RS20080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
INR75_RS20080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
INR75_RS20085	COG0730	response to heat
INR75_RS20120	COG1442	glycosyl transferase family 8
INR75_RS20120	COG1216	Glycosyl transferase, family 2
INR75_RS20125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
INR75_RS20130	COG0110	maltose O-acetyltransferase activity
INR75_RS20150	COG0438	transferase activity, transferring glycosyl groups
INR75_RS20175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
INR75_RS20180	COG1216	Glycosyl transferase, family 2
INR75_RS20215	COG0784	Response regulator, receiver
INR75_RS20225	COG4251	negative regulation of phosphorylation
INR75_RS20235	COG4251	negative regulation of phosphorylation
INR75_RS20245	COG3279	Response regulator of the LytR AlgR family
INR75_RS20250	COG1472	Belongs to the glycosyl hydrolase 3 family
INR75_RS20255	COG0657	acetylesterase activity
INR75_RS20255	COG2755	lipolytic protein G-D-S-L family
INR75_RS20270	COG0431	NADPH-dependent FMN reductase
INR75_RS20295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
INR75_RS20305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INR75_RS20310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
INR75_RS20315	COG1611	Belongs to the LOG family
INR75_RS20320	COG2890	protein-(glutamine-N5) methyltransferase activity
INR75_RS20330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INR75_RS20330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
INR75_RS20335	COG1011	Hydrolase
INR75_RS20340	COG1739	Uncharacterized protein family UPF0029
INR75_RS20345	COG0824	Thioesterase
INR75_RS20375	COG3279	Response regulator of the LytR AlgR family
INR75_RS20380	COG3279	Response regulator of the LytR AlgR family
INR75_RS20435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
INR75_RS20500	COG1629	transport