locus-tag	class	description
ZBT109_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZBT109_RS00010	COG0592	DNA-directed DNA polymerase activity
ZBT109_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZBT109_RS00020	COG0187	DNA topoisomerase II activity
ZBT109_RS00025	COG2995	paraquat-inducible protein a
ZBT109_RS00030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ZBT109_RS00030	COG3008	intermembrane lipid transfer
ZBT109_RS00035	COG3009	Protein conserved in bacteria
ZBT109_RS00050	COG0438	transferase activity, transferring glycosyl groups
ZBT109_RS00060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ZBT109_RS00065	COG2885	chlorophyll binding
ZBT109_RS00070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZBT109_RS00085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ZBT109_RS00090	COG1981	membrane
ZBT109_RS00095	COG0316	Belongs to the HesB IscA family
ZBT109_RS00105	COG0445	tRNA wobble uridine modification
ZBT109_RS00110	COG0357	Ribosomal RNA small subunit methyltransferase G
ZBT109_RS00115	COG1192	Involved in chromosome partitioning
ZBT109_RS00120	COG1475	DNA binding
ZBT109_RS00130	COG0356	it plays a direct role in the translocation of protons across the membrane
ZBT109_RS00140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZBT109_RS00145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZBT109_RS00150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZBT109_RS00155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZBT109_RS00165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZBT109_RS00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZBT109_RS00190	COG1349	DNA-binding transcription factor activity
ZBT109_RS00195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZBT109_RS00215	COG0667	Aldo Keto reductase
ZBT109_RS00245	COG3265	gluconokinase activity
ZBT109_RS00250	COG0006	proline dipeptidase activity
ZBT109_RS00255	COG0307	riboflavin synthase, alpha
ZBT109_RS00270	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ZBT109_RS00275	COG0306	phosphate transporter
ZBT109_RS00285	COG1621	beta-fructofuranosidase activity
ZBT109_RS00325	COG0322	excinuclease ABC activity
ZBT109_RS00345	COG2321	neutral zinc metallopeptidase
ZBT109_RS00360	COG0210	DNA helicase
ZBT109_RS00365	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
ZBT109_RS00370	COG3023	N-Acetylmuramoyl-L-alanine amidase
ZBT109_RS00385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ZBT109_RS00415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ZBT109_RS00425	COG2188	Transcriptional regulator
ZBT109_RS00445	COG0840	transmembrane signaling receptor activity
ZBT109_RS00450	COG5297	Belongs to the glycosyl hydrolase family 6
ZBT109_RS00455	COG0751	glycine-tRNA ligase activity
ZBT109_RS00460	COG0752	glycyl-tRNA synthetase alpha subunit
ZBT109_RS00465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZBT109_RS00475	COG0463	Glycosyl transferase, family 2
ZBT109_RS00490	COG0840	transmembrane signaling receptor activity
ZBT109_RS00495	COG0840	transmembrane signaling receptor activity
ZBT109_RS00500	COG0840	transmembrane signaling receptor activity
ZBT109_RS00525	COG1346	cytolysis
ZBT109_RS00530	COG0789	Transcriptional regulator
ZBT109_RS00535	COG0659	secondary active sulfate transmembrane transporter activity
ZBT109_RS00540	COG0405	Gamma-glutamyltransferase
ZBT109_RS00575	COG3226	Transcriptional regulator
ZBT109_RS00580	COG0110	maltose O-acetyltransferase activity
ZBT109_RS00585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ZBT109_RS00595	COG1561	YicC-like family, N-terminal region
ZBT109_RS00600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZBT109_RS00605	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ZBT109_RS00610	COG0708	Exodeoxyribonuclease III
ZBT109_RS00630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZBT109_RS00640	COG0366	Alpha amylase catalytic
ZBT109_RS00665	COG1519	Transferase
ZBT109_RS00670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ZBT109_RS00670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ZBT109_RS00675	COG0859	PFAM glycosyl transferase family 9
ZBT109_RS00685	COG0859	PFAM glycosyl transferase family 9
ZBT109_RS00690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ZBT109_RS00700	COG1881	PFAM PEBP family protein
ZBT109_RS00705	COG0814	amino acid
ZBT109_RS00710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZBT109_RS00715	COG2271	Major facilitator Superfamily
ZBT109_RS00720	COG0456	acetyltransferase
ZBT109_RS00725	COG1278	Cold shock
ZBT109_RS00740	COG5297	Belongs to the glycosyl hydrolase family 6
ZBT109_RS00755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ZBT109_RS00780	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ZBT109_RS00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZBT109_RS00805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZBT109_RS00815	COG1714	RDD family
ZBT109_RS00820	COG0793	Belongs to the peptidase S41A family
ZBT109_RS00825	COG4942	peptidase
ZBT109_RS00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZBT109_RS00835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ZBT109_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ZBT109_RS00845	COG0189	ligase activity
ZBT109_RS00855	COG1678	Uncharacterized ACR, COG1678
ZBT109_RS00860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZBT109_RS00865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZBT109_RS00875	COG1722	exodeoxyribonuclease VII activity
ZBT109_RS00880	COG0142	geranyltranstransferase activity
ZBT109_RS00885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZBT109_RS00890	COG0586	Pfam SNARE associated Golgi protein
ZBT109_RS00905	COG3539	Fimbrial protein
ZBT109_RS00910	COG3121	Chaperone
ZBT109_RS00925	COG5295	Hep Hag repeat protein
ZBT109_RS00930	COG2771	luxR family
ZBT109_RS00940	COG1113	amino acid transport
ZBT109_RS00955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZBT109_RS00960	COG0583	DNA-binding transcription factor activity
ZBT109_RS00985	COG1823	symporter activity
ZBT109_RS01000	COG1696	Membrane protein involved in D-alanine export
ZBT109_RS01025	COG2153	protein acetylation
ZBT109_RS01045	COG0583	DNA-binding transcription factor activity
ZBT109_RS01050	COG1012	belongs to the aldehyde dehydrogenase family
ZBT109_RS01090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZBT109_RS01095	COG2867	negative regulation of translational initiation
ZBT109_RS01100	COG2914	Belongs to the UPF0125 (RnfH) family
ZBT109_RS01105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZBT109_RS01115	COG1742	UPF0060 membrane protein
ZBT109_RS01120	COG0497	DNA recombination
ZBT109_RS01125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZBT109_RS01130	COG0443	Heat shock 70 kDa protein
ZBT109_RS01135	COG0484	heat shock protein binding
ZBT109_RS01140	COG2040	homocysteine
ZBT109_RS01145	COG0833	amino acid
ZBT109_RS01150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZBT109_RS01175	COG0730	response to heat
ZBT109_RS01185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ZBT109_RS01190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ZBT109_RS01195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZBT109_RS01200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZBT109_RS01205	COG0149	triose-phosphate isomerase activity
ZBT109_RS01230	COG0779	Required for maturation of 30S ribosomal subunits
ZBT109_RS01235	COG2251	uridine kinase activity
ZBT109_RS01235	COG0195	Participates in both transcription termination and antitermination
ZBT109_RS01240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZBT109_RS01245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZBT109_RS01250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZBT109_RS01255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZBT109_RS01260	COG1185	polyribonucleotide nucleotidyltransferase activity
ZBT109_RS01265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ZBT109_RS01270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ZBT109_RS01275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ZBT109_RS01290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZBT109_RS01295	COG1489	DNA binding
ZBT109_RS01300	COG2813	Specifically methylates the guanine in position
ZBT109_RS01300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZBT109_RS01305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZBT109_RS01310	COG0762	integral membrane protein
ZBT109_RS01325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZBT109_RS01360	COG1271	oxidase subunit
ZBT109_RS01365	COG1294	oxidase, subunit
ZBT109_RS01375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZBT109_RS01410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZBT109_RS01415	COG0081	regulation of translation
ZBT109_RS01420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZBT109_RS01425	COG0222	ribosome binding
ZBT109_RS01430	COG0085	RNA polymerase activity
ZBT109_RS01435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZBT109_RS01440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZBT109_RS01445	COG0049	tRNA binding
ZBT109_RS01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZBT109_RS01455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZBT109_RS01460	COG0051	transcription antitermination factor activity, RNA binding
ZBT109_RS01465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZBT109_RS01470	COG0088	Forms part of the polypeptide exit tunnel
ZBT109_RS01475	COG0089	rRNA binding
ZBT109_RS01480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZBT109_RS01485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZBT109_RS01490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZBT109_RS01495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZBT109_RS01500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZBT109_RS01505	COG0255	Belongs to the universal ribosomal protein uL29 family
ZBT109_RS01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZBT109_RS01515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZBT109_RS01520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZBT109_RS01525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZBT109_RS01530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZBT109_RS01535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZBT109_RS01540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZBT109_RS01545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZBT109_RS01550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZBT109_RS01555	COG1841	ribosomal large subunit assembly
ZBT109_RS01560	COG0200	Binds to the 23S rRNA
ZBT109_RS01570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZBT109_RS01575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZBT109_RS01580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZBT109_RS01585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZBT109_RS01590	COG0202	RNA polymerase activity
ZBT109_RS01595	COG0203	ribosomal protein L17
ZBT109_RS01605	COG0629	single-stranded DNA binding
ZBT109_RS01635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZBT109_RS01640	COG0415	Belongs to the DNA photolyase family
ZBT109_RS01645	COG1090	epimerase
ZBT109_RS01655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZBT109_RS01660	COG3479	Phenolic acid decarboxylase
ZBT109_RS01675	COG0142	geranyltranstransferase activity
ZBT109_RS01710	COG0604	alcohol dehydrogenase
ZBT109_RS01720	COG0604	alcohol dehydrogenase
ZBT109_RS01720	COG3321	synthase
ZBT109_RS01755	COG0318	PFAM AMP-dependent synthetase and ligase
ZBT109_RS01760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZBT109_RS01765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZBT109_RS01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZBT109_RS01775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZBT109_RS01780	COG0268	Binds directly to 16S ribosomal RNA
ZBT109_RS01790	COG0196	riboflavin kinase activity
ZBT109_RS01795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZBT109_RS01800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZBT109_RS01805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZBT109_RS01860	COG1733	regulation of RNA biosynthetic process
ZBT109_RS01865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZBT109_RS01870	COG1301	dicarboxylic acid transport
ZBT109_RS01895	COG0583	DNA-binding transcription factor activity
ZBT109_RS01900	COG1280	lysine exporter protein (LysE YggA)
ZBT109_RS01905	COG0477	Major facilitator Superfamily
ZBT109_RS01925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ZBT109_RS01935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZBT109_RS01940	COG3842	ATPase activity
ZBT109_RS01945	COG1176	ABC-type spermidine putrescine transport system, permease component I
ZBT109_RS01950	COG1177	transmembrane transport
ZBT109_RS01960	COG0174	glutamine synthetase
ZBT109_RS01965	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ZBT109_RS01980	COG2807	transmembrane transport
ZBT109_RS01985	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS02000	COG0028	Belongs to the TPP enzyme family
ZBT109_RS02010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZBT109_RS02025	COG0765	amino acid transport
ZBT109_RS02030	COG1126	abc transporter atp-binding protein
ZBT109_RS02045	COG1918	ferrous iron import across plasma membrane
ZBT109_RS02060	COG0850	regulation of cytokinetic process
ZBT109_RS02065	COG2894	cell division
ZBT109_RS02070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ZBT109_RS02090	COG2925	Exonuclease
ZBT109_RS02095	COG1025	Belongs to the peptidase M16 family
ZBT109_RS02130	COG4536	flavin adenine dinucleotide binding
ZBT109_RS02135	COG4137	Cytochrome C assembly protein
ZBT109_RS02140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZBT109_RS02145	COG0228	four-way junction DNA binding
ZBT109_RS02150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZBT109_RS02155	COG0336	Belongs to the RNA methyltransferase TrmD family
ZBT109_RS02160	COG0335	large ribosomal subunit rRNA binding
ZBT109_RS02175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ZBT109_RS02190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZBT109_RS02200	COG4172	Belongs to the ABC transporter superfamily
ZBT109_RS02205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZBT109_RS02210	COG0601	transmembrane transport
ZBT109_RS02220	COG4166	transmembrane transport
ZBT109_RS02230	COG4166	transmembrane transport
ZBT109_RS02245	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ZBT109_RS02255	COG0271	Belongs to the BolA IbaG family
ZBT109_RS02265	COG0456	acetyltransferase
ZBT109_RS02275	COG0742	ribosomal rna small subunit methyltransferase
ZBT109_RS02280	COG0552	protein localization to endoplasmic reticulum
ZBT109_RS02285	COG2884	Cell division ATP-binding protein ftsE
ZBT109_RS02290	COG2177	Part of the ABC transporter FtsEX involved in
ZBT109_RS02310	COG0167	dihydroorotate dehydrogenase activity
ZBT109_RS02315	COG0543	2 iron, 2 sulfur cluster binding
ZBT109_RS02320	COG2814	Major facilitator Superfamily
ZBT109_RS02330	COG1309	transcriptional regulator
ZBT109_RS02335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZBT109_RS02350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZBT109_RS02355	COG0588	phosphoglycerate mutase activity
ZBT109_RS02360	COG2003	Belongs to the UPF0758 family
ZBT109_RS02375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZBT109_RS02380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZBT109_RS02395	COG0180	Tryptophanyl-tRNA synthetase
ZBT109_RS02400	COG1183	phosphatidylcholine synthase activity
ZBT109_RS02405	COG0366	Alpha amylase catalytic
ZBT109_RS02410	COG0076	glutamate decarboxylase activity
ZBT109_RS02415	COG0129	dihydroxy-acid dehydratase activity
ZBT109_RS02430	COG0494	nUDIX hydrolase
ZBT109_RS02435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ZBT109_RS02440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ZBT109_RS02445	COG2183	response to ionizing radiation
ZBT109_RS02450	COG2918	glutathione biosynthetic process
ZBT109_RS02455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ZBT109_RS02475	COG0494	nUDIX hydrolase
ZBT109_RS02480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZBT109_RS02485	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZBT109_RS02495	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ZBT109_RS02505	COG1566	PFAM secretion protein HlyD family protein
ZBT109_RS02510	COG1289	transmembrane transporter activity
ZBT109_RS02520	COG3133	Outer membrane lipoprotein
ZBT109_RS02525	COG2850	peptidyl-arginine hydroxylation
ZBT109_RS02535	COG2915	High frequency lysogenization protein hflD homolog
ZBT109_RS02540	COG0482	sulfurtransferase activity
ZBT109_RS02555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ZBT109_RS02560	COG0542	response to heat
ZBT109_RS02575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZBT109_RS02580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZBT109_RS02585	COG1674	ftsk spoiiie
ZBT109_RS02590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ZBT109_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS02610	COG0604	alcohol dehydrogenase
ZBT109_RS02615	COG2315	Protein conserved in bacteria
ZBT109_RS02625	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
ZBT109_RS02625	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ZBT109_RS02630	COG3051	citrate lyase alpha subunit
ZBT109_RS02645	COG0179	Fumarylacetoacetate (FAA) hydrolase
ZBT109_RS02665	COG4572	Cation transport regulator
ZBT109_RS02685	COG2017	converts alpha-aldose to the beta-anomer
ZBT109_RS02690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZBT109_RS02695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZBT109_RS02700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZBT109_RS02705	COG0167	dihydroorotate dehydrogenase activity
ZBT109_RS02710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ZBT109_RS02710	COG0116	Belongs to the methyltransferase superfamily
ZBT109_RS02730	COG0501	Belongs to the peptidase M48B family
ZBT109_RS02735	COG0436	Aminotransferase
ZBT109_RS02740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ZBT109_RS02745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZBT109_RS02780	COG2271	Major facilitator Superfamily
ZBT109_RS02790	COG0477	Major facilitator Superfamily
ZBT109_RS02800	COG1131	(ABC) transporter
ZBT109_RS02805	COG0842	Transport permease protein
ZBT109_RS02810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZBT109_RS02810	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZBT109_RS02815	COG0778	Nitroreductase
ZBT109_RS02835	COG0745	RESPONSE REGULATOR receiver
ZBT109_RS02840	COG5002	protein histidine kinase activity
ZBT109_RS02840	COG5000	phosphorelay sensor kinase activity
ZBT109_RS02885	COG2081	HI0933 family
ZBT109_RS02905	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
ZBT109_RS02910	COG4575	ribosome binding
ZBT109_RS02930	COG1196	nuclear chromosome segregation
ZBT109_RS02930	COG3264	Mechanosensitive ion channel
ZBT109_RS02940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZBT109_RS02945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZBT109_RS02965	COG2207	Transcriptional regulator
ZBT109_RS02970	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZBT109_RS02975	COG2814	Major facilitator Superfamily
ZBT109_RS02985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZBT109_RS02990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZBT109_RS02995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZBT109_RS03005	COG3100	YcgL domain-containing protein
ZBT109_RS03010	COG2983	Belongs to the UPF0260 family
ZBT109_RS03030	COG1464	Belongs to the NlpA lipoprotein family
ZBT109_RS03035	COG2011	ABC-type metal ion transport system permease component
ZBT109_RS03040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ZBT109_RS03050	COG1733	regulation of RNA biosynthetic process
ZBT109_RS03065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ZBT109_RS03070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ZBT109_RS03075	COG4208	sulfate ABC transporter
ZBT109_RS03080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ZBT109_RS03095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ZBT109_RS03115	COG1454	alcohol dehydrogenase
ZBT109_RS03120	COG1643	Atp-dependent helicase
ZBT109_RS03125	COG2853	Lipoprotein
ZBT109_RS03130	COG2814	Major facilitator Superfamily
ZBT109_RS03135	COG3118	belongs to the thioredoxin family
ZBT109_RS03140	COG0730	response to heat
ZBT109_RS03155	COG1252	NADH dehydrogenase
ZBT109_RS03175	COG0512	Glutamine amidotransferase of anthranilate synthase
ZBT109_RS03180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZBT109_RS03185	COG0134	indole-3-glycerol-phosphate synthase activity
ZBT109_RS03190	COG0584	glycerophosphoryl diester phosphodiesterase
ZBT109_RS03200	COG2197	response regulator
ZBT109_RS03210	COG2771	luxR family
ZBT109_RS03225	COG2197	response regulator
ZBT109_RS03275	COG4695	Portal protein
ZBT109_RS03295	COG1621	beta-fructofuranosidase activity
ZBT109_RS03300	COG3539	Fimbrial protein
ZBT109_RS03310	COG3188	usher protein
ZBT109_RS03325	COG2072	flavoprotein involved in K transport
ZBT109_RS03345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZBT109_RS03350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZBT109_RS03355	COG0657	acetylesterase activity
ZBT109_RS03380	COG4589	Belongs to the CDS family
ZBT109_RS03400	COG3022	response to hydroperoxide
ZBT109_RS03420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ZBT109_RS03430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ZBT109_RS03435	COG0492	ferredoxin-NADP+ reductase activity
ZBT109_RS03440	COG2900	Belongs to the SlyX family
ZBT109_RS03445	COG1278	Cold shock
ZBT109_RS03455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZBT109_RS03465	COG1393	Belongs to the ArsC family
ZBT109_RS03480	COG0052	Belongs to the universal ribosomal protein uS2 family
ZBT109_RS03485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZBT109_RS03490	COG0528	UMP kinase activity
ZBT109_RS03495	COG0233	cytoplasmic translational termination
ZBT109_RS03500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZBT109_RS03510	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZBT109_RS03530	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZBT109_RS03535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZBT109_RS03540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZBT109_RS03545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZBT109_RS03550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZBT109_RS03560	COG0825	malonyl-CoA metabolic process
ZBT109_RS03565	COG0037	tRNA processing
ZBT109_RS03575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ZBT109_RS03585	COG0783	Belongs to the Dps family
ZBT109_RS03590	COG0745	RESPONSE REGULATOR receiver
ZBT109_RS03595	COG2205	protein histidine kinase activity
ZBT109_RS03600	COG0583	DNA-binding transcription factor activity
ZBT109_RS03605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZBT109_RS03610	COG0346	lactoylglutathione lyase activity
ZBT109_RS03630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZBT109_RS03640	COG0140	phosphoribosyl-ATP diphosphatase activity
ZBT109_RS03645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZBT109_RS03655	COG2226	methyltransferase
ZBT109_RS03665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZBT109_RS03670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZBT109_RS03685	COG0018	arginyl-trna synthetase
ZBT109_RS03690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ZBT109_RS03695	COG0254	rRNA binding
ZBT109_RS03730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZBT109_RS03735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZBT109_RS03740	COG0067	glutamate synthase
ZBT109_RS03740	COG0069	glutamate synthase activity
ZBT109_RS03740	COG0070	glutamate synthase
ZBT109_RS03745	COG0493	'glutamate synthase
ZBT109_RS03750	COG0446	pyridine nucleotide-disulphide oxidoreductase
ZBT109_RS03755	COG0113	porphobilinogen synthase activity
ZBT109_RS03760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ZBT109_RS03775	COG4771	TonB-dependent receptor
ZBT109_RS03800	COG3433	isochorismatase activity
ZBT109_RS03800	COG2226	methyltransferase
ZBT109_RS03800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZBT109_RS03805	COG1132	(ABC) transporter
ZBT109_RS03810	COG1132	(ABC) transporter
ZBT109_RS03820	COG1464	Belongs to the NlpA lipoprotein family
ZBT109_RS03825	COG1464	Belongs to the NlpA lipoprotein family
ZBT109_RS03830	COG2011	ABC-type metal ion transport system permease component
ZBT109_RS03835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ZBT109_RS03870	COG4574	serine-type endopeptidase inhibitor activity
ZBT109_RS03880	COG0800	Aldolase
ZBT109_RS03895	COG0477	Major facilitator Superfamily
ZBT109_RS03915	COG0004	ammonium transporteR
ZBT109_RS03920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ZBT109_RS03940	COG0747	negative chemotaxis
ZBT109_RS03945	COG0601	transmembrane transport
ZBT109_RS03950	COG4172	Belongs to the ABC transporter superfamily
ZBT109_RS03960	COG1132	(ABC) transporter
ZBT109_RS03975	COG2197	response regulator
ZBT109_RS03980	COG2197	response regulator
ZBT109_RS03985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZBT109_RS04010	COG0803	Belongs to the bacterial solute-binding protein 9 family
ZBT109_RS04015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZBT109_RS04020	COG1121	(ABC) transporter
ZBT109_RS04025	COG1444	tRNA N-acetyltransferase activity
ZBT109_RS04030	COG2195	Cleaves the N-terminal amino acid of tripeptides
ZBT109_RS04120	COG2977	Belongs to the P-Pant transferase superfamily
ZBT109_RS04150	COG0739	heme binding
ZBT109_RS04175	COG1515	deoxyribonuclease V activity
ZBT109_RS04180	COG2706	6-phosphogluconolactonase activity
ZBT109_RS04190	COG0420	3'-5' exonuclease activity
ZBT109_RS04205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZBT109_RS04210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZBT109_RS04215	COG0625	glutathione transferase activity
ZBT109_RS04220	COG2969	positive regulation of protein catabolic process
ZBT109_RS04230	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ZBT109_RS04235	COG0792	nuclease activity
ZBT109_RS04245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZBT109_RS04260	COG0275	rRNA processing
ZBT109_RS04275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZBT109_RS04280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ZBT109_RS04285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZBT109_RS04290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZBT109_RS04295	COG0772	Belongs to the SEDS family
ZBT109_RS04300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZBT109_RS04305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZBT109_RS04310	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZBT109_RS04315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZBT109_RS04330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ZBT109_RS04340	COG0653	protein targeting
ZBT109_RS04345	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZBT109_RS04350	COG0352	thiamine-phosphate diphosphorylase activity
ZBT109_RS04355	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ZBT109_RS04360	COG0237	dephospho-CoA kinase activity
ZBT109_RS04375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ZBT109_RS04390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ZBT109_RS04410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ZBT109_RS04415	COG1605	Chorismate mutase
ZBT109_RS04415	COG0077	Prephenate dehydratase
ZBT109_RS04425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZBT109_RS04440	COG1114	Component of the transport system for branched-chain amino acids
ZBT109_RS04455	COG0459	protein refolding
ZBT109_RS04460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZBT109_RS04465	COG3030	protein affecting phage T7 exclusion by the F plasmid
ZBT109_RS04470	COG1555	photosystem II stabilization
ZBT109_RS04470	COG1596	polysaccharide export
ZBT109_RS04475	COG0284	orotidine-5'-phosphate decarboxylase activity
ZBT109_RS04480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ZBT109_RS04490	COG0776	regulation of translation
ZBT109_RS04500	COG1289	transmembrane transporter activity
ZBT109_RS04525	COG0673	inositol 2-dehydrogenase activity
ZBT109_RS04580	COG0322	excinuclease ABC activity
ZBT109_RS04590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ZBT109_RS04595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZBT109_RS04600	COG0137	argininosuccinate synthase activity
ZBT109_RS04610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ZBT109_RS04615	COG2878	Part of a membrane complex involved in electron transport
ZBT109_RS04620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZBT109_RS04620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZBT109_RS04625	COG0489	protein tyrosine kinase activity
ZBT109_RS04630	COG0717	Belongs to the dCTP deaminase family
ZBT109_RS04640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZBT109_RS04650	COG0432	Pfam Uncharacterised protein family UPF0047
ZBT109_RS04655	COG1982	Orn Lys Arg decarboxylase major
ZBT109_RS04700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ZBT109_RS04705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ZBT109_RS04710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ZBT109_RS04715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ZBT109_RS04730	COG0788	formyltetrahydrofolate deformylase activity
ZBT109_RS04735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ZBT109_RS04760	COG1764	response to oxidative stress
ZBT109_RS04765	COG0656	L-ascorbic acid biosynthetic process
ZBT109_RS04770	COG0477	Major facilitator Superfamily
ZBT109_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS04785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ZBT109_RS04790	COG0163	prenyltransferase activity
ZBT109_RS04795	COG1074	ATP-dependent DNA helicase activity
ZBT109_RS04800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ZBT109_RS04825	COG0247	lactate metabolic process
ZBT109_RS04830	COG1139	Iron-sulfur cluster binding protein
ZBT109_RS04845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ZBT109_RS04850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ZBT109_RS04860	COG2197	response regulator
ZBT109_RS04885	COG0583	DNA-binding transcription factor activity
ZBT109_RS04930	COG2814	Major facilitator Superfamily
ZBT109_RS04960	COG3772	lysozyme
ZBT109_RS04975	COG4975	Glucose uptake
ZBT109_RS05010	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ZBT109_RS05015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ZBT109_RS05020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZBT109_RS05025	COG0215	cysteine-tRNA ligase activity
ZBT109_RS05030	COG0366	Alpha amylase catalytic
ZBT109_RS05035	COG0366	Alpha amylase catalytic
ZBT109_RS05040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ZBT109_RS05045	COG1854	S-ribosylhomocysteine lyase activity
ZBT109_RS05050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZBT109_RS05075	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZBT109_RS05080	COG0740	serine-type endopeptidase activity
ZBT109_RS05085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZBT109_RS05090	COG1509	lysine 2,3-aminomutase activity
ZBT109_RS05095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZBT109_RS05135	COG3961	Belongs to the TPP enzyme family
ZBT109_RS05145	COG2249	NAD(P)H dehydrogenase (quinone) activity
ZBT109_RS05165	COG2010	Cytochrome c
ZBT109_RS05170	COG1473	amidohydrolase
ZBT109_RS05175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZBT109_RS05200	COG0410	ABC transporter
ZBT109_RS05210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZBT109_RS05220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ZBT109_RS05225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZBT109_RS05230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZBT109_RS05235	COG0072	phenylalanine-tRNA ligase activity
ZBT109_RS05240	COG0776	regulation of translation
ZBT109_RS05245	COG0716	FMN binding
ZBT109_RS05250	COG0741	lytic transglycosylase activity
ZBT109_RS05260	COG2197	response regulator
ZBT109_RS05265	COG0326	Molecular chaperone. Has ATPase activity
ZBT109_RS05270	COG2992	FlgJ-related protein
ZBT109_RS05280	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZBT109_RS05295	COG0640	Transcriptional regulator
ZBT109_RS05310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZBT109_RS05330	COG0066	3-isopropylmalate dehydratase activity
ZBT109_RS05335	COG0473	3-isopropylmalate dehydrogenase activity
ZBT109_RS05355	COG0246	Mannitol dehydrogenase
ZBT109_RS05375	COG0602	queuosine metabolic process
ZBT109_RS05380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZBT109_RS05385	COG0826	peptidase U32
ZBT109_RS05405	COG2831	hemolysin activation secretion protein
ZBT109_RS05410	COG3210	domain, Protein
ZBT109_RS05460	COG0135	phosphoribosylanthranilate isomerase activity
ZBT109_RS05465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZBT109_RS05470	COG0285	dihydrofolate synthase activity
ZBT109_RS05500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ZBT109_RS05505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZBT109_RS05530	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZBT109_RS05535	COG0563	adenylate kinase activity
ZBT109_RS05540	COG1214	PFAM Peptidase M22, glycoprotease
ZBT109_RS05545	COG0742	ribosomal rna small subunit methyltransferase
ZBT109_RS05565	COG3091	SprT-like family
ZBT109_RS05590	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ZBT109_RS05595	COG4988	ABC transporter
ZBT109_RS05600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZBT109_RS05635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ZBT109_RS05645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ZBT109_RS05665	COG0540	Belongs to the ATCase OTCase family
ZBT109_RS05675	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
ZBT109_RS05680	COG0425	Belongs to the sulfur carrier protein TusA family
ZBT109_RS05690	COG3101	peptidyl-lysine hydroxylation
ZBT109_RS05820	COG5410	chromosome segregation
ZBT109_RS05850	COG1598	PFAM Uncharacterised protein family UPF0150
ZBT109_RS05855	COG1621	beta-fructofuranosidase activity
ZBT109_RS05995	COG3561	AntA/AntB antirepressor
ZBT109_RS06005	COG0582	viral genome integration into host DNA
ZBT109_RS06035	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ZBT109_RS06035	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ZBT109_RS06040	COG1280	lysine exporter protein (LysE YggA)
ZBT109_RS06060	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
ZBT109_RS06105	COG0038	chloride channel
ZBT109_RS06115	COG4771	TonB-dependent receptor
ZBT109_RS06120	COG2382	esterase
ZBT109_RS06125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZBT109_RS06125	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ZBT109_RS06135	COG0084	hydrolase, TatD family'
ZBT109_RS06140	COG1902	pentaerythritol trinitrate reductase activity
ZBT109_RS06145	COG1309	transcriptional regulator
ZBT109_RS06160	COG0488	(ABC) transporter
ZBT109_RS06170	COG0589	response to stress
ZBT109_RS06190	COG0495	leucyl-tRNA aminoacylation
ZBT109_RS06195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZBT109_RS06200	COG4535	Mg2 and Co2 transporter CorC
ZBT109_RS06205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZBT109_RS06210	COG1702	phosphate starvation-inducible protein PhoH
ZBT109_RS06215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZBT109_RS06230	COG4991	sh3 domain protein
ZBT109_RS06235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZBT109_RS06240	COG2827	Endonuclease containing a URI domain
ZBT109_RS06260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ZBT109_RS06265	COG2923	Belongs to the DsrF TusC family
ZBT109_RS06285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZBT109_RS06290	COG0531	amino acid
ZBT109_RS06315	COG4221	oxidoreductase activity
ZBT109_RS06330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZBT109_RS06335	COG1944	ATP diphosphatase activity
ZBT109_RS06340	COG1388	LysM domain
ZBT109_RS06340	COG0741	lytic transglycosylase activity
ZBT109_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZBT109_RS06355	COG0328	RNA-DNA hybrid ribonuclease activity
ZBT109_RS06365	COG2816	NAD+ diphosphatase activity
ZBT109_RS06370	COG0616	signal peptide processing
ZBT109_RS06375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ZBT109_RS06385	COG0596	Alpha beta hydrolase
ZBT109_RS06390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ZBT109_RS06405	COG0444	Belongs to the ABC transporter superfamily
ZBT109_RS06410	COG4608	Belongs to the ABC transporter superfamily
ZBT109_RS06420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZBT109_RS06435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZBT109_RS06440	COG1120	ATPase activity
ZBT109_RS06445	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZBT109_RS06450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZBT109_RS06455	COG4592	Periplasmic binding protein
ZBT109_RS06460	COG1169	isochorismate synthase
ZBT109_RS06465	COG1021	2,3-dihydroxybenzoate-AMP ligase
ZBT109_RS06470	COG3433	isochorismatase activity
ZBT109_RS06470	COG1535	isochorismatase
ZBT109_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS06480	COG1280	lysine exporter protein (LysE YggA)
ZBT109_RS06490	COG2166	iron-sulfur cluster assembly
ZBT109_RS06495	COG2197	response regulator
ZBT109_RS06500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZBT109_RS06505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZBT109_RS06510	COG0735	belongs to the Fur family
ZBT109_RS06515	COG1741	Belongs to the pirin family
ZBT109_RS06525	COG5434	Belongs to the glycosyl hydrolase 28 family
ZBT109_RS06530	COG5434	Belongs to the glycosyl hydrolase 28 family
ZBT109_RS06535	COG0384	phenazine biosynthesis protein PhzF
ZBT109_RS06605	COG0754	glutathionylspermidine amidase activity
ZBT109_RS06615	COG3766	membrane
ZBT109_RS06630	COG2733	membrane
ZBT109_RS06635	COG1914	H( )-stimulated, divalent metal cation uptake system
ZBT109_RS06640	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ZBT109_RS06640	COG0316	Belongs to the HesB IscA family
ZBT109_RS06645	COG0302	gtp cyclohydrolase
ZBT109_RS06655	COG3137	Salt-induced outer membrane protein
ZBT109_RS06670	COG1597	lipid kinase activity
ZBT109_RS06675	COG1285	pathogenesis
ZBT109_RS06685	COG0156	8-amino-7-oxononanoate synthase activity
ZBT109_RS06690	COG0596	Alpha beta hydrolase
ZBT109_RS06695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZBT109_RS06695	COG0596	Alpha beta hydrolase
ZBT109_RS06695	COG2226	methyltransferase
ZBT109_RS06730	COG2188	Transcriptional regulator
ZBT109_RS06745	COG2943	transferase activity, transferring hexosyl groups
ZBT109_RS06750	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZBT109_RS06760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZBT109_RS06775	COG0110	maltose O-acetyltransferase activity
ZBT109_RS06820	COG0308	aminopeptidase N
ZBT109_RS06825	COG5000	phosphorelay sensor kinase activity
ZBT109_RS06830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ZBT109_RS06845	COG0438	transferase activity, transferring glycosyl groups
ZBT109_RS06850	COG0671	phosphoesterase, PA-phosphatase related
ZBT109_RS06865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZBT109_RS06870	COG0321	lipoyl(octanoyl) transferase activity
ZBT109_RS06880	COG1686	Belongs to the peptidase S11 family
ZBT109_RS06885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ZBT109_RS06890	COG2951	lytic endotransglycosylase activity
ZBT109_RS06895	COG0772	Belongs to the SEDS family
ZBT109_RS06900	COG0768	penicillin binding
ZBT109_RS06905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZBT109_RS06915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZBT109_RS06920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZBT109_RS06925	COG0586	Pfam SNARE associated Golgi protein
ZBT109_RS06930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZBT109_RS06940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZBT109_RS06950	COG0511	ligase activity, forming carbon-carbon bonds
ZBT109_RS06960	COG2264	protein methyltransferase activity
ZBT109_RS06965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ZBT109_RS06985	COG2197	response regulator
ZBT109_RS06995	COG2197	response regulator
ZBT109_RS07005	COG0138	bifunctional purine biosynthesis protein purh
ZBT109_RS07025	COG0288	reversible hydration of carbon dioxide
ZBT109_RS07045	COG2911	Protein conserved in bacteria
ZBT109_RS07050	COG0729	surface antigen
ZBT109_RS07055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZBT109_RS07070	COG2885	chlorophyll binding
ZBT109_RS07075	COG0823	Involved in the tonB-independent uptake of proteins
ZBT109_RS07095	COG0824	Thioesterase
ZBT109_RS07100	COG2255	four-way junction helicase activity
ZBT109_RS07105	COG0632	four-way junction helicase activity
ZBT109_RS07110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZBT109_RS07115	COG0217	transcriptional regulatory protein
ZBT109_RS07120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZBT109_RS07130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZBT109_RS07135	COG2239	Acts as a magnesium transporter
ZBT109_RS07140	COG0671	phosphoesterase, PA-phosphatase related
ZBT109_RS07145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZBT109_RS07155	COG0583	DNA-binding transcription factor activity
ZBT109_RS07175	COG0556	nucleotide-excision repair
ZBT109_RS07190	COG0789	Transcriptional regulator
ZBT109_RS07210	COG0673	inositol 2-dehydrogenase activity
ZBT109_RS07215	COG0084	hydrolase, TatD family'
ZBT109_RS07220	COG1970	mechanosensitive ion channel activity
ZBT109_RS07230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZBT109_RS07235	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZBT109_RS07265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ZBT109_RS07270	COG1953	Uracil, thiamine, allantoin
ZBT109_RS07285	COG0154	amidase activity
ZBT109_RS07290	COG1126	abc transporter atp-binding protein
ZBT109_RS07295	COG0765	amino acid transport
ZBT109_RS07300	COG0765	amino acid transport
ZBT109_RS07310	COG0254	rRNA binding
ZBT109_RS07320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZBT109_RS07355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ZBT109_RS07360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZBT109_RS07365	COG2261	transglycosylase associated protein
ZBT109_RS07435	COG1797	cobyrinic acid a,c-diamide synthase activity
ZBT109_RS07455	COG1492	cobalamin metabolic process
ZBT109_RS07475	COG0252	asparaginase activity
ZBT109_RS07485	COG0583	DNA-binding transcription factor activity
ZBT109_RS07495	COG1611	Belongs to the LOG family
ZBT109_RS07500	COG1012	belongs to the aldehyde dehydrogenase family
ZBT109_RS07515	COG1902	pentaerythritol trinitrate reductase activity
ZBT109_RS07550	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ZBT109_RS07590	COG2076	Multidrug Resistance protein
ZBT109_RS07595	COG2076	Multidrug Resistance protein
ZBT109_RS07600	COG0726	polysaccharide deacetylase
ZBT109_RS07605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZBT109_RS07605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZBT109_RS07610	COG0463	Glycosyl transferase, family 2
ZBT109_RS07615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ZBT109_RS07620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ZBT109_RS07625	COG0248	Ppx GppA phosphatase
ZBT109_RS07630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZBT109_RS07670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZBT109_RS07695	COG2814	Major facilitator Superfamily
ZBT109_RS07710	COG1766	The M ring may be actively involved in energy transduction
ZBT109_RS07725	COG1157	protein secretion by the type III secretion system
ZBT109_RS07740	COG1580	Controls the rotational direction of flagella during chemotaxis
ZBT109_RS07765	COG1987	bacterial-type flagellum assembly
ZBT109_RS07805	COG1012	belongs to the aldehyde dehydrogenase family
ZBT109_RS07815	COG2197	response regulator
ZBT109_RS07865	COG1256	bacterial-type flagellum assembly
ZBT109_RS07875	COG1706	bacterial-type flagellum-dependent cell motility
ZBT109_RS07880	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ZBT109_RS07890	COG4787	bacterial-type flagellum-dependent cell motility
ZBT109_RS07900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZBT109_RS07910	COG1815	bacterial-type flagellum-dependent cell motility
ZBT109_RS07930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZBT109_RS07935	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ZBT109_RS07940	COG3454	Phosphonate metabolism
ZBT109_RS07945	COG4778	phosphonate C-P lyase system protein PhnL
ZBT109_RS07950	COG4107	phosphonate C-P lyase system protein PhnK
ZBT109_RS07955	COG3627	carbon phosphorus lyase activity
ZBT109_RS07960	COG3626	phosphonate metabolism
ZBT109_RS07965	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ZBT109_RS07970	COG3624	Phosphonate C-P lyase system protein PhnG
ZBT109_RS07980	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
ZBT109_RS07980	COG0028	Belongs to the TPP enzyme family
ZBT109_RS08005	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ZBT109_RS08010	COG0745	RESPONSE REGULATOR receiver
ZBT109_RS08025	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZBT109_RS08030	COG0835	chemotaxis
ZBT109_RS08035	COG0643	Histidine kinase
ZBT109_RS08035	COG2198	Histidine kinase
ZBT109_RS08040	COG1360	Flagellar Motor Protein
ZBT109_RS08095	COG0730	response to heat
ZBT109_RS08100	COG0791	NLP P60 protein
ZBT109_RS08120	COG0753	catalase activity
ZBT109_RS08135	COG3121	Chaperone
ZBT109_RS08145	COG3539	Fimbrial protein
ZBT109_RS08150	COG0840	transmembrane signaling receptor activity
ZBT109_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS08170	COG0582	viral genome integration into host DNA
ZBT109_RS08220	COG2974	May be involved in recombination
ZBT109_RS08225	COG0629	single-stranded DNA binding
ZBT109_RS08230	COG3723	Recombinational DNA repair protein, rece pathway
ZBT109_RS08235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZBT109_RS08410	COG2826	transposase and inactivated derivatives, IS30 family
ZBT109_RS08420	COG2197	response regulator
ZBT109_RS08435	COG4558	Periplasmic binding protein
ZBT109_RS08440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZBT109_RS08445	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZBT109_RS08455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZBT109_RS08460	COG1253	flavin adenine dinucleotide binding
ZBT109_RS08465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZBT109_RS08470	COG1047	Peptidyl-prolyl cis-trans
ZBT109_RS08475	COG2131	deaminase
ZBT109_RS08480	COG1040	competence protein
ZBT109_RS08490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZBT109_RS08500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZBT109_RS08505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ZBT109_RS08515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZBT109_RS08525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ZBT109_RS08550	COG1187	pseudouridine synthase activity
ZBT109_RS08555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ZBT109_RS08560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ZBT109_RS08565	COG1061	Type III restriction enzyme res subunit
ZBT109_RS08580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ZBT109_RS08590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZBT109_RS08600	COG2824	Alkylphosphonate utilization operon protein PhnA
ZBT109_RS08615	COG2197	response regulator
ZBT109_RS08650	COG1196	nuclear chromosome segregation
ZBT109_RS08665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZBT109_RS08665	COG0519	Catalyzes the synthesis of GMP from XMP
ZBT109_RS08685	COG2205	protein histidine kinase activity
ZBT109_RS08690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZBT109_RS08690	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ZBT109_RS08700	COG0009	L-threonylcarbamoyladenylate synthase
ZBT109_RS08705	COG0613	PHP domain protein
ZBT109_RS08710	COG2917	probably involved in intracellular septation
ZBT109_RS08715	COG2350	Protein conserved in bacteria
ZBT109_RS08720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ZBT109_RS08720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ZBT109_RS08735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZBT109_RS08740	COG3115	cell septum assembly
ZBT109_RS08745	COG1196	nuclear chromosome segregation
ZBT109_RS08760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZBT109_RS08765	COG1138	Cytochrome C-type biogenesis protein
ZBT109_RS08770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ZBT109_RS08790	COG4133	protoheme IX ABC transporter activity
ZBT109_RS08795	COG1739	Uncharacterized protein family UPF0029
ZBT109_RS08835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ZBT109_RS08845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZBT109_RS08850	COG2137	regulation of response to DNA damage stimulus
ZBT109_RS08855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZBT109_RS08860	COG1546	Belongs to the CinA family
ZBT109_RS08865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZBT109_RS08870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ZBT109_RS08880	COG0148	phosphopyruvate hydratase activity
ZBT109_RS08885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZBT109_RS08890	COG0504	CTP synthase activity
ZBT109_RS08900	COG2205	protein histidine kinase activity
ZBT109_RS08905	COG0745	RESPONSE REGULATOR receiver
ZBT109_RS08910	COG0668	transmembrane transport
ZBT109_RS08920	COG3040	lipid binding
ZBT109_RS08935	COG4160	amino acid transport
ZBT109_RS08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZBT109_RS08955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZBT109_RS08960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZBT109_RS08965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ZBT109_RS08975	COG1335	isochorismatase
ZBT109_RS08980	COG0569	domain protein
ZBT109_RS08990	COG3148	PFAM DTW domain containing protein
ZBT109_RS08995	COG0564	pseudouridine synthase activity
ZBT109_RS09000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ZBT109_RS09005	COG0795	lipopolysaccharide-transporting ATPase activity
ZBT109_RS09010	COG0795	lipopolysaccharide-transporting ATPase activity
ZBT109_RS09020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZBT109_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS09040	COG0525	valine-tRNA ligase activity
ZBT109_RS09045	COG0671	phosphoesterase, PA-phosphatase related
ZBT109_RS09050	COG0671	phosphoesterase, PA-phosphatase related
ZBT109_RS09055	COG1652	LysM domain
ZBT109_RS09060	COG1294	oxidase, subunit
ZBT109_RS09065	COG1271	oxidase subunit
ZBT109_RS09090	COG0366	Alpha amylase catalytic
ZBT109_RS09095	COG2949	membrane
ZBT109_RS09105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZBT109_RS09110	COG0719	Fe-S assembly protein
ZBT109_RS09115	COG0396	ATPase activity
ZBT109_RS09120	COG0719	Fe-S assembly protein
ZBT109_RS09130	COG1289	transmembrane transporter activity
ZBT109_RS09135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZBT109_RS09140	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ZBT109_RS09145	COG0330	HflC and HflK could
ZBT109_RS09150	COG0330	HflC and HflK could
ZBT109_RS09155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZBT109_RS09160	COG1923	regulation of RNA biosynthetic process
ZBT109_RS09165	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZBT109_RS09170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZBT109_RS09175	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZBT109_RS09180	COG0802	atpase or kinase
ZBT109_RS09185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ZBT109_RS09185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ZBT109_RS09195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ZBT109_RS09200	COG1162	GTPase activity
ZBT109_RS09205	COG0583	DNA-binding transcription factor activity
ZBT109_RS09210	COG2233	PERMEase
ZBT109_RS09220	COG2252	PERMEase
ZBT109_RS09230	COG0688	phosphatidylethanolamine metabolic process
ZBT109_RS09235	COG3047	cAMP biosynthetic process
ZBT109_RS09235	COG2885	chlorophyll binding
ZBT109_RS09255	COG1191	sigma factor activity
ZBT109_RS09260	COG0442	prolyl-tRNA aminoacylation
ZBT109_RS09265	COG2211	Major facilitator Superfamily
ZBT109_RS09285	COG2223	nitrite transmembrane transporter activity
ZBT109_RS09295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZBT109_RS09300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZBT109_RS09305	COG3956	TIGRFAM MazG family protein
ZBT109_RS09310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ZBT109_RS09315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZBT109_RS09325	COG1381	Involved in DNA repair and RecF pathway recombination
ZBT109_RS09330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZBT109_RS09335	COG0571	ribonuclease III activity
ZBT109_RS09345	COG0481	GTPase activity
ZBT109_RS09350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZBT109_RS09355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZBT109_RS09360	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZBT109_RS09365	COG2835	tetraacyldisaccharide 4'-kinase activity
ZBT109_RS09370	COG1663	tetraacyldisaccharide 4'-kinase activity
ZBT109_RS09375	COG1132	(ABC) transporter
ZBT109_RS09390	COG1136	(ABC) transporter
ZBT109_RS09400	COG1064	alcohol dehydrogenase
ZBT109_RS09405	COG2207	Transcriptional regulator
ZBT109_RS09415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZBT109_RS09420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZBT109_RS09430	COG2022	thiamine diphosphate biosynthetic process
ZBT109_RS09445	COG0392	lysyltransferase activity
ZBT109_RS09450	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ZBT109_RS09455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZBT109_RS09485	COG0469	pyruvate kinase activity
ZBT109_RS09495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZBT109_RS09510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ZBT109_RS09515	COG0351	phosphomethylpyrimidine kinase
ZBT109_RS09520	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZBT109_RS09555	COG0151	Belongs to the GarS family
ZBT109_RS09565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZBT109_RS09570	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZBT109_RS09575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZBT109_RS09580	COG0047	phosphoribosylformylglycinamidine synthase activity
ZBT109_RS09585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZBT109_RS09590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZBT109_RS09595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZBT109_RS09600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZBT109_RS09605	COG1199	ATP-dependent helicase activity
ZBT109_RS09610	COG0513	Belongs to the DEAD box helicase family
ZBT109_RS09620	COG0708	Exodeoxyribonuclease III
ZBT109_RS09670	COG2314	TM2 domain
ZBT109_RS09675	COG2314	TM2 domain
ZBT109_RS09690	COG0084	hydrolase, TatD family'
ZBT109_RS09700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZBT109_RS09705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZBT109_RS09710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZBT109_RS09715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZBT109_RS09720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZBT109_RS09735	COG0416	fatty acid biosynthetic process
ZBT109_RS09740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ZBT109_RS09745	COG1399	metal-binding, possibly nucleic acid-binding protein
ZBT109_RS09755	COG3023	N-Acetylmuramoyl-L-alanine amidase
ZBT109_RS09770	COG1530	ribonuclease E activity
ZBT109_RS09780	COG0560	Phosphoserine phosphatase
ZBT109_RS09780	COG3830	Belongs to the UPF0237 family
ZBT109_RS09790	COG0187	DNA topoisomerase II activity
ZBT109_RS09795	COG3150	esterase
ZBT109_RS09800	COG0166	Belongs to the GPI family
ZBT109_RS09805	COG4106	trans-aconitate 2-methyltransferase activity
ZBT109_RS09810	COG0500	methyltransferase
ZBT109_RS09815	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ZBT109_RS09825	COG0494	nUDIX hydrolase
ZBT109_RS09830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZBT109_RS09840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZBT109_RS09845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZBT109_RS09855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZBT109_RS09855	COG1648	precorrin-2 dehydrogenase activity
ZBT109_RS09875	COG1063	alcohol dehydrogenase
ZBT109_RS09880	COG1063	alcohol dehydrogenase
ZBT109_RS09900	COG0366	Alpha amylase catalytic
ZBT109_RS09925	COG0463	Glycosyl transferase, family 2
ZBT109_RS09940	COG1216	Glycosyl transferase, family 2
ZBT109_RS09950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZBT109_RS09965	COG0488	(ABC) transporter
ZBT109_RS09980	COG1560	Kdo2-lipid A biosynthetic process
ZBT109_RS09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZBT109_RS09990	COG1538	Outer membrane efflux protein
ZBT109_RS09995	COG3539	Fimbrial protein
ZBT109_RS10000	COG3188	usher protein
ZBT109_RS10005	COG3121	Chaperone
ZBT109_RS10030	COG3539	Fimbrial protein
ZBT109_RS10040	COG1388	LysM domain
ZBT109_RS10040	COG4942	peptidase
ZBT109_RS10045	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZBT109_RS10050	COG0585	pseudouridine synthase activity
ZBT109_RS10055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZBT109_RS10060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZBT109_RS10065	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ZBT109_RS10085	COG1522	sequence-specific DNA binding
ZBT109_RS10105	COG1295	ribonuclease BN
ZBT109_RS10110	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZBT109_RS10160	COG0358	DNA primase activity
ZBT109_RS10165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZBT109_RS10170	COG1115	amino acid carrier protein
ZBT109_RS10175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZBT109_RS10180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ZBT109_RS10185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ZBT109_RS10190	COG0617	tRNA 3'-terminal CCA addition
ZBT109_RS10195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ZBT109_RS10200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ZBT109_RS10205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZBT109_RS10210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZBT109_RS10215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ZBT109_RS10220	COG0628	permease
ZBT109_RS10225	COG0537	adenosine 5'-monophosphoramidase activity
ZBT109_RS10240	COG2111	Na H antiporter
ZBT109_RS10240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ZBT109_RS10245	COG1006	Multisubunit Na H antiporter MnhC subunit
ZBT109_RS10250	COG0651	ATP synthesis coupled electron transport
ZBT109_RS10260	COG2212	antiporter activity
ZBT109_RS10270	COG0371	Dehydrogenase
ZBT109_RS10275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZBT109_RS10290	COG0305	Participates in initiation and elongation during chromosome replication
ZBT109_RS10295	COG0359	binds to the 23S rRNA
ZBT109_RS10300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZBT109_RS10305	COG0360	Binds together with S18 to 16S ribosomal RNA
ZBT109_RS10310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZBT109_RS10315	COG0557	exoribonuclease II activity
ZBT109_RS10365	COG0037	tRNA processing
ZBT109_RS10370	COG2198	Histidine kinase
ZBT109_RS10370	COG2205	protein histidine kinase activity
ZBT109_RS10370	COG0784	Response regulator, receiver
ZBT109_RS10375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ZBT109_RS10380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZBT109_RS10390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZBT109_RS10395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZBT109_RS10400	COG5007	Belongs to the BolA IbaG family
ZBT109_RS10415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ZBT109_RS10420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZBT109_RS10425	COG1127	ABC transporter
ZBT109_RS10435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ZBT109_RS10445	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ZBT109_RS10450	COG1137	ATPase activity
ZBT109_RS10470	COG1660	Displays ATPase and GTPase activities
ZBT109_RS10480	COG0312	modulator of DNA gyrase
ZBT109_RS10485	COG3028	Belongs to the UPF0307 family
ZBT109_RS10495	COG0312	modulator of DNA gyrase
ZBT109_RS10510	COG0424	maF-like protein
ZBT109_RS10520	COG1792	Involved in formation and maintenance of cell shape
ZBT109_RS10525	COG1077	Cell shape determining protein MreB Mrl
ZBT109_RS10530	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZBT109_RS10535	COG0154	amidase activity
ZBT109_RS10540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZBT109_RS10560	COG0456	acetyltransferase
ZBT109_RS10595	COG1177	transmembrane transport
ZBT109_RS10600	COG1176	ABC-type spermidine putrescine transport system, permease component I
ZBT109_RS10605	COG3842	ATPase activity
ZBT109_RS10610	COG2890	protein-(glutamine-N5) methyltransferase activity
ZBT109_RS10615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZBT109_RS10620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ZBT109_RS10630	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ZBT109_RS10640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZBT109_RS10655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZBT109_RS10660	COG0193	aminoacyl-tRNA hydrolase activity
ZBT109_RS10665	COG0012	GTP binding
ZBT109_RS10700	COG0326	Molecular chaperone. Has ATPase activity
ZBT109_RS10715	COG0586	Pfam SNARE associated Golgi protein
ZBT109_RS10725	COG1362	aminopeptidase activity
ZBT109_RS10835	COG0583	DNA-binding transcription factor activity
ZBT109_RS10845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZBT109_RS10850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZBT109_RS10885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ZBT109_RS10910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZBT109_RS10915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZBT109_RS10920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZBT109_RS10930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZBT109_RS10930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZBT109_RS10935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZBT109_RS10950	COG2813	Specifically methylates the guanine in position
ZBT109_RS10955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ZBT109_RS11015	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS11035	COG2113	Glycine betaine
ZBT109_RS11050	COG0517	IMP dehydrogenase activity
ZBT109_RS11050	COG4175	Glycine betaine
ZBT109_RS11055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZBT109_RS11060	COG3300	MHYT domain
ZBT109_RS11060	COG5001	Diguanylate cyclase
ZBT109_RS11070	COG1215	transferase activity, transferring glycosyl groups
ZBT109_RS11075	COG0726	polysaccharide deacetylase
ZBT109_RS11075	COG1649	PFAM Uncharacterised BCR, COG1649
ZBT109_RS11085	COG1649	PFAM Uncharacterised BCR, COG1649
ZBT109_RS11085	COG0726	polysaccharide deacetylase
ZBT109_RS11110	COG1045	serine acetyltransferase
ZBT109_RS11120	COG3634	alkyl hydroperoxide reductase activity
ZBT109_RS11125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZBT109_RS11145	COG3477	response to acidic pH
ZBT109_RS11155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ZBT109_RS11160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ZBT109_RS11165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZBT109_RS11170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZBT109_RS11180	COG2223	nitrite transmembrane transporter activity
ZBT109_RS11190	COG1621	beta-fructofuranosidase activity
ZBT109_RS11210	COG0280	phosphate acetyltransferase
ZBT109_RS11210	COG0857	belongs to the CobB CobQ family
ZBT109_RS11215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ZBT109_RS11230	COG0287	Prephenate dehydrogenase
ZBT109_RS11230	COG1605	Chorismate mutase
ZBT109_RS11235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ZBT109_RS11240	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ZBT109_RS11245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZBT109_RS11250	COG0488	(ABC) transporter
ZBT109_RS11255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ZBT109_RS11260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ZBT109_RS11290	COG5295	Hep Hag repeat protein
ZBT109_RS11305	COG3152	Membrane
ZBT109_RS11335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZBT109_RS11340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZBT109_RS11345	COG0534	Mate efflux family protein
ZBT109_RS11365	COG0159	tryptophan synthase activity
ZBT109_RS11420	COG0546	phosphoglycolate phosphatase activity
ZBT109_RS11425	COG0667	Aldo Keto reductase
ZBT109_RS11430	COG0025	NhaP-type Na H and K H
ZBT109_RS11435	COG0668	transmembrane transport
ZBT109_RS11440	COG0386	Belongs to the glutathione peroxidase family
ZBT109_RS11470	COG2453	phosphatase
ZBT109_RS11470	COG0671	phosphoesterase, PA-phosphatase related
ZBT109_RS11475	COG2267	carboxylic ester hydrolase activity
ZBT109_RS11480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZBT109_RS11605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZBT109_RS11610	COG0343	queuine tRNA-ribosyltransferase activity
ZBT109_RS11615	COG1862	Preprotein translocase
ZBT109_RS11630	COG0483	inositol monophosphate 1-phosphatase activity
ZBT109_RS11645	COG1104	cysteine desulfurase activity
ZBT109_RS11655	COG0105	UTP biosynthetic process
ZBT109_RS11660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZBT109_RS11675	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZBT109_RS11680	COG0124	histidyl-tRNA synthetase
ZBT109_RS11695	COG1160	GTP binding
ZBT109_RS11705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZBT109_RS11710	COG0408	coproporphyrinogen oxidase activity
ZBT109_RS11715	COG0009	L-threonylcarbamoyladenylate synthase
ZBT109_RS11720	COG0758	DNA mediated transformation
ZBT109_RS11725	COG0242	peptide deformylase activity
ZBT109_RS11730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZBT109_RS11740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZBT109_RS11745	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ZBT109_RS11745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ZBT109_RS11755	COG0837	glucose binding
ZBT109_RS11765	COG1113	amino acid transport
ZBT109_RS11780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ZBT109_RS11785	COG0671	phosphoesterase, PA-phosphatase related
ZBT109_RS11810	COG1737	Transcriptional regulator
ZBT109_RS11820	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZBT109_RS11825	COG3753	Protein conserved in bacteria
ZBT109_RS11830	COG2814	Major facilitator Superfamily
ZBT109_RS11840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZBT109_RS11855	COG2233	PERMEase
ZBT109_RS11875	COG1064	alcohol dehydrogenase
ZBT109_RS11890	COG2217	Heavy metal translocating P-type atpase
ZBT109_RS11905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZBT109_RS11910	COG3700	Belongs to the class B bacterial acid phosphatase family
ZBT109_RS11935	COG0181	hydroxymethylbilane synthase activity
ZBT109_RS11940	COG0165	Argininosuccinate lyase
ZBT109_RS11955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZBT109_RS11960	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ZBT109_RS11975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ZBT109_RS11995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZBT109_RS12000	COG0581	inorganic phosphate transmembrane transporter activity
ZBT109_RS12005	COG0573	inorganic phosphate transmembrane transporter activity
ZBT109_RS12010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZBT109_RS12025	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS12030	COG0737	Belongs to the 5'-nucleotidase family
ZBT109_RS12035	COG1011	Hydrolase
ZBT109_RS12055	COG0626	cystathionine gamma-synthase activity
ZBT109_RS12070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ZBT109_RS12090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ZBT109_RS12095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ZBT109_RS12115	COG0649	NAD binding
ZBT109_RS12115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ZBT109_RS12120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ZBT109_RS12125	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ZBT109_RS12170	COG1126	abc transporter atp-binding protein
ZBT109_RS12175	COG0765	amino acid transport
ZBT109_RS12180	COG4597	amino acid ABC transporter
ZBT109_RS12185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ZBT109_RS12200	COG0604	alcohol dehydrogenase
ZBT109_RS12205	COG1122	ATPase activity
ZBT109_RS12210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ZBT109_RS12215	COG1268	BioY protein
ZBT109_RS12220	COG2860	membrane
ZBT109_RS12265	COG2363	Small membrane protein
ZBT109_RS12270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZBT109_RS12285	COG0488	(ABC) transporter
ZBT109_RS12290	COG3154	lipid carrier protein
ZBT109_RS12295	COG0038	chloride channel
ZBT109_RS12310	COG1085	galactose-1-phosphate uridylyltransferase
ZBT109_RS12315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ZBT109_RS12325	COG0826	peptidase U32
ZBT109_RS12330	COG0826	peptidase U32
ZBT109_RS12360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZBT109_RS12365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZBT109_RS12370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ZBT109_RS12380	COG4143	(ABC) transporter
ZBT109_RS12385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZBT109_RS12390	COG4221	oxidoreductase activity
ZBT109_RS12395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ZBT109_RS12465	COG0602	queuosine metabolic process
ZBT109_RS12475	COG0513	Belongs to the DEAD box helicase family
ZBT109_RS12495	COG0659	secondary active sulfate transmembrane transporter activity
ZBT109_RS12525	COG0446	pyridine nucleotide-disulphide oxidoreductase
ZBT109_RS12535	COG3104	oligopeptide transport
ZBT109_RS12545	COG1028	Short-chain dehydrogenase reductase Sdr
ZBT109_RS12580	COG1764	response to oxidative stress
ZBT109_RS12605	COG0583	DNA-binding transcription factor activity
ZBT109_RS12615	COG1942	4-Oxalocrotonate Tautomerase
ZBT109_RS12625	COG0523	cobalamin synthesis protein
ZBT109_RS12630	COG0488	(ABC) transporter
ZBT109_RS12645	COG4695	Portal protein
ZBT109_RS12685	COG3772	lysozyme
ZBT109_RS12705	COG1621	beta-fructofuranosidase activity
ZBT109_RS12815	COG2932	Transcriptional regulator
ZBT109_RS12900	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ZBT109_RS12915	COG0131	Imidazoleglycerol-phosphate dehydratase
ZBT109_RS12920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZBT109_RS12925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZBT109_RS12930	COG0107	imidazoleglycerol-phosphate synthase activity
ZBT109_RS12945	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ZBT109_RS12955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZBT109_RS12960	COG0346	lactoylglutathione lyase activity
ZBT109_RS12970	COG0477	Major facilitator Superfamily
ZBT109_RS13010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ZBT109_RS13015	COG0733	neurotransmitter:sodium symporter activity
ZBT109_RS13020	COG0339	signal peptide processing
ZBT109_RS13025	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ZBT109_RS13055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZBT109_RS13060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZBT109_RS13065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ZBT109_RS13070	COG0531	amino acid
ZBT109_RS13075	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZBT109_RS13080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ZBT109_RS13085	COG0126	phosphoglycerate kinase activity
ZBT109_RS13090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ZBT109_RS13095	COG0594	ribonuclease P activity
ZBT109_RS13100	COG0706	membrane insertase activity
ZBT109_RS13105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZBT109_RS13115	COG1064	alcohol dehydrogenase
ZBT109_RS13135	COG3541	Predicted nucleotidyltransferase
ZBT109_RS13160	COG2205	protein histidine kinase activity
ZBT109_RS13180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZBT109_RS13190	COG0473	3-isopropylmalate dehydrogenase activity
ZBT109_RS13195	COG0436	Aminotransferase
ZBT109_RS13200	COG0791	NLP P60 protein
ZBT109_RS13200	COG1388	LysM domain
ZBT109_RS13235	COG1217	gtp-binding protein TYPA
ZBT109_RS13245	COG1621	beta-fructofuranosidase activity
ZBT109_RS13250	COG1621	beta-fructofuranosidase activity
ZBT109_RS13270	COG2814	Major facilitator Superfamily
ZBT109_RS13280	COG1414	Transcriptional regulator
ZBT109_RS13290	COG0702	epimerase
ZBT109_RS13295	COG1733	regulation of RNA biosynthetic process
ZBT109_RS13300	COG2999	glutathione oxidoreductase activity
ZBT109_RS13305	COG2999	glutathione oxidoreductase activity
ZBT109_RS13315	COG0194	GDP metabolic process
ZBT109_RS13320	COG1758	RNA polymerase activity
ZBT109_RS13325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ZBT109_RS13340	COG0583	DNA-binding transcription factor activity
ZBT109_RS13345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ZBT109_RS13350	COG2217	Heavy metal translocating P-type atpase
ZBT109_RS13365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZBT109_RS13370	COG2814	Major facilitator Superfamily
ZBT109_RS13400	COG3386	PFAM SMP-30 Gluconolaconase
ZBT109_RS13430	COG2223	nitrite transmembrane transporter activity
ZBT109_RS13435	COG1301	dicarboxylic acid transport
ZBT109_RS13445	COG2197	response regulator
ZBT109_RS13465	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
ZBT109_RS13475	COG3179	chitinase