locus-tag	class	description
ZZ6_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZZ6_RS00010	COG0488	(ABC) transporter
ZZ6_RS00015	COG2885	chlorophyll binding
ZZ6_RS00015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZZ6_RS00020	COG4702	Belongs to the UPF0303 family
ZZ6_RS00025	COG0670	Belongs to the BI1 family
ZZ6_RS00035	COG1058	Belongs to the CinA family
ZZ6_RS00035	COG1546	Belongs to the CinA family
ZZ6_RS00040	COG0024	Methionine aminopeptidase
ZZ6_RS00055	COG0308	aminopeptidase N
ZZ6_RS00075	COG2321	neutral zinc metallopeptidase
ZZ6_RS00085	COG1280	lysine exporter protein (LysE YggA)
ZZ6_RS00090	COG1741	Belongs to the pirin family
ZZ6_RS00095	COG0583	DNA-binding transcription factor activity
ZZ6_RS00100	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZZ6_RS00105	COG2353	YceI-like domain
ZZ6_RS00110	COG0668	transmembrane transport
ZZ6_RS00115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZZ6_RS00120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZZ6_RS00135	COG1660	Displays ATPase and GTPase activities
ZZ6_RS00140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZZ6_RS00145	COG0642	Histidine kinase
ZZ6_RS00150	COG0745	RESPONSE REGULATOR receiver
ZZ6_RS00170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZZ6_RS00175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZZ6_RS00180	COG2244	polysaccharide biosynthetic process
ZZ6_RS00190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZZ6_RS00195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZZ6_RS00200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZZ6_RS00205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ZZ6_RS00210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZZ6_RS00220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ZZ6_RS00220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ZZ6_RS00225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZZ6_RS00240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZZ6_RS00245	COG0321	lipoyl(octanoyl) transferase activity
ZZ6_RS00280	COG0602	queuosine metabolic process
ZZ6_RS00285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZZ6_RS00300	COG2261	transglycosylase associated protein
ZZ6_RS00305	COG2223	nitrite transmembrane transporter activity
ZZ6_RS00330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZZ6_RS00335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZZ6_RS00340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZZ6_RS00350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZZ6_RS00360	COG1012	belongs to the aldehyde dehydrogenase family
ZZ6_RS00370	COG0156	8-amino-7-oxononanoate synthase activity
ZZ6_RS00390	COG0519	Catalyzes the synthesis of GMP from XMP
ZZ6_RS00390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZZ6_RS00395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZZ6_RS00400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ZZ6_RS00405	COG1138	Cytochrome C-type biogenesis protein
ZZ6_RS00410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZZ6_RS00415	COG3088	subunit of a heme lyase
ZZ6_RS00440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZZ6_RS00450	COG2866	Carboxypeptidase
ZZ6_RS00455	COG0588	phosphoglycerate mutase activity
ZZ6_RS00470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZZ6_RS00485	COG1064	alcohol dehydrogenase
ZZ6_RS00495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZZ6_RS00535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZZ6_RS00535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZZ6_RS00540	COG0302	gtp cyclohydrolase
ZZ6_RS00545	COG4948	Mandelate Racemase Muconate Lactonizing
ZZ6_RS00550	COG0359	binds to the 23S rRNA
ZZ6_RS00555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZZ6_RS00560	COG0360	Binds together with S18 to 16S ribosomal RNA
ZZ6_RS00565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZZ6_RS00580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZZ6_RS00585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZZ6_RS00590	COG0805	protein transport
ZZ6_RS00615	COG0513	Belongs to the DEAD box helicase family
ZZ6_RS00625	COG0166	Belongs to the GPI family
ZZ6_RS00640	COG3158	transport of potassium into the cell
ZZ6_RS00650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZZ6_RS00670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZZ6_RS00675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZZ6_RS00685	COG0156	8-amino-7-oxononanoate synthase activity
ZZ6_RS00690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZZ6_RS00700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ZZ6_RS00705	COG0758	DNA mediated transformation
ZZ6_RS00710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZZ6_RS00710	COG1754	DNA topoisomerase type I activity
ZZ6_RS00715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZZ6_RS00720	COG0756	dUTP diphosphatase activity
ZZ6_RS00725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZZ6_RS00730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZZ6_RS00735	COG2226	methyltransferase
ZZ6_RS00745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZZ6_RS00770	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZZ6_RS00785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZZ6_RS00790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZZ6_RS00800	COG2205	protein histidine kinase activity
ZZ6_RS00815	COG3724	N-succinylarginine dihydrolase activity
ZZ6_RS00820	COG1472	Belongs to the glycosyl hydrolase 3 family
ZZ6_RS00830	COG2971	BadF BadG BcrA BcrD
ZZ6_RS00840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZZ6_RS00845	COG1040	competence protein
ZZ6_RS00850	COG0745	RESPONSE REGULATOR receiver
ZZ6_RS00855	COG0704	Plays a role in the regulation of phosphate uptake
ZZ6_RS00865	COG0688	phosphatidylethanolamine metabolic process
ZZ6_RS00870	COG1183	phosphatidylcholine synthase activity
ZZ6_RS00880	COG0052	Belongs to the universal ribosomal protein uS2 family
ZZ6_RS00885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZZ6_RS00890	COG0528	UMP kinase activity
ZZ6_RS00895	COG0233	cytoplasmic translational termination
ZZ6_RS00900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZZ6_RS00905	COG0575	Belongs to the CDS family
ZZ6_RS00910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZZ6_RS00915	COG0750	zinc metalloprotease
ZZ6_RS00920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZZ6_RS00930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZZ6_RS00935	COG0254	rRNA binding
ZZ6_RS00950	COG0492	ferredoxin-NADP+ reductase activity
ZZ6_RS00955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZZ6_RS00960	COG0440	acetolactate synthase activity
ZZ6_RS00965	COG0028	Belongs to the TPP enzyme family
ZZ6_RS00970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZZ6_RS00980	COG1858	cytochrome C peroxidase
ZZ6_RS00985	COG0312	modulator of DNA gyrase
ZZ6_RS00995	COG0288	reversible hydration of carbon dioxide
ZZ6_RS01000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZZ6_RS01005	COG2867	negative regulation of translational initiation
ZZ6_RS01010	COG1058	Belongs to the CinA family
ZZ6_RS01010	COG1546	Belongs to the CinA family
ZZ6_RS01020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZZ6_RS01020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZZ6_RS01030	COG2204	response regulator
ZZ6_RS01035	COG5000	phosphorelay sensor kinase activity
ZZ6_RS01040	COG2204	response regulator
ZZ6_RS01060	COG0776	regulation of translation
ZZ6_RS01085	COG1968	undecaprenyl-diphosphatase activity
ZZ6_RS01100	COG1252	NADH dehydrogenase
ZZ6_RS01105	COG2917	probably involved in intracellular septation
ZZ6_RS01110	COG2807	transmembrane transport
ZZ6_RS01120	COG1522	sequence-specific DNA binding
ZZ6_RS01135	COG2205	protein histidine kinase activity
ZZ6_RS01140	COG0802	atpase or kinase
ZZ6_RS01145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ZZ6_RS01155	COG1074	ATP-dependent DNA helicase activity
ZZ6_RS01165	COG0557	exoribonuclease II activity
ZZ6_RS01170	COG3956	TIGRFAM MazG family protein
ZZ6_RS01180	COG0084	hydrolase, TatD family'
ZZ6_RS01190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZZ6_RS01195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZZ6_RS01200	COG1686	Belongs to the peptidase S11 family
ZZ6_RS01210	COG2951	lytic endotransglycosylase activity
ZZ6_RS01215	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ZZ6_RS01220	COG0457	Tetratricopeptide repeat
ZZ6_RS01225	COG1215	transferase activity, transferring glycosyl groups
ZZ6_RS01230	COG1215	transferase activity, transferring glycosyl groups
ZZ6_RS01245	COG0335	large ribosomal subunit rRNA binding
ZZ6_RS01250	COG0336	Belongs to the RNA methyltransferase TrmD family
ZZ6_RS01255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZZ6_RS01260	COG0228	four-way junction DNA binding
ZZ6_RS01265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZZ6_RS01270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZZ6_RS01275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZZ6_RS01280	COG0552	protein localization to endoplasmic reticulum
ZZ6_RS01285	COG0484	heat shock protein binding
ZZ6_RS01315	COG1842	Phage shock protein A
ZZ6_RS01325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZZ6_RS01345	COG0617	tRNA 3'-terminal CCA addition
ZZ6_RS01355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZZ6_RS01360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZZ6_RS01365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZZ6_RS01370	COG0581	inorganic phosphate transmembrane transporter activity
ZZ6_RS01375	COG0573	inorganic phosphate transmembrane transporter activity
ZZ6_RS01380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZZ6_RS01390	COG1970	mechanosensitive ion channel activity
ZZ6_RS01400	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ZZ6_RS01425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZZ6_RS01435	COG0137	argininosuccinate synthase activity
ZZ6_RS01445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ZZ6_RS01450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZZ6_RS01480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZZ6_RS01485	COG1104	cysteine desulfurase activity
ZZ6_RS01490	COG2945	thiolester hydrolase activity
ZZ6_RS01495	COG0019	diaminopimelate decarboxylase activity
ZZ6_RS01505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZZ6_RS01510	COG1127	ABC transporter
ZZ6_RS01525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZZ6_RS01530	COG0424	maF-like protein
ZZ6_RS01540	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ZZ6_RS01560	COG0277	FAD linked oxidase domain protein
ZZ6_RS01565	COG3781	membrane
ZZ6_RS01570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZZ6_RS01580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZZ6_RS01585	COG0352	thiamine-phosphate diphosphorylase activity
ZZ6_RS01585	COG0351	phosphomethylpyrimidine kinase
ZZ6_RS01590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZZ6_RS01595	COG3104	oligopeptide transport
ZZ6_RS01600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZZ6_RS01605	COG0009	L-threonylcarbamoyladenylate synthase
ZZ6_RS01610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZZ6_RS01615	COG0800	Aldolase
ZZ6_RS01635	COG0071	Belongs to the small heat shock protein (HSP20) family
ZZ6_RS01650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZZ6_RS01655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZZ6_RS01670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZZ6_RS01675	COG4172	Belongs to the ABC transporter superfamily
ZZ6_RS01685	COG4206	TonB-dependent receptor
ZZ6_RS01695	COG0667	Aldo Keto reductase
ZZ6_RS01725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZZ6_RS01735	COG2252	PERMEase
ZZ6_RS01745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZZ6_RS01750	COG2814	Major facilitator Superfamily
ZZ6_RS01755	COG1566	PFAM secretion protein HlyD family protein
ZZ6_RS01770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ZZ6_RS01785	COG2857	Cytochrome c1
ZZ6_RS01790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZZ6_RS01795	COG0723	plastoquinol--plastocyanin reductase activity
ZZ6_RS01810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZZ6_RS01815	COG0408	coproporphyrinogen oxidase activity
ZZ6_RS01825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZZ6_RS01830	COG0740	serine-type endopeptidase activity
ZZ6_RS01840	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZZ6_RS01860	COG1621	beta-fructofuranosidase activity
ZZ6_RS01875	COG1846	Transcriptional regulator
ZZ6_RS01880	COG0402	S-adenosylhomocysteine deaminase activity
ZZ6_RS01885	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ZZ6_RS01890	COG1448	Aminotransferase
ZZ6_RS01895	COG0697	spore germination
ZZ6_RS01925	COG3191	aminopeptidase activity
ZZ6_RS01930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZZ6_RS01940	COG1278	Cold shock
ZZ6_RS01945	COG0653	protein targeting
ZZ6_RS01950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZZ6_RS01990	COG2217	Heavy metal translocating P-type atpase
ZZ6_RS01995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZZ6_RS02000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZZ6_RS02040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZZ6_RS02050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZZ6_RS02065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZZ6_RS02065	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZZ6_RS02100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZZ6_RS02100	COG1199	ATP-dependent helicase activity
ZZ6_RS02105	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZZ6_RS02130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZZ6_RS02135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZZ6_RS02140	COG0840	transmembrane signaling receptor activity
ZZ6_RS02145	COG2198	Histidine kinase
ZZ6_RS02145	COG0643	Histidine kinase
ZZ6_RS02150	COG2201	protein-glutamate methylesterase activity
ZZ6_RS02165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZZ6_RS02180	COG1657	PFAM Prenyltransferase squalene oxidase
ZZ6_RS02185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ZZ6_RS02190	COG1562	ergosterol biosynthetic process
ZZ6_RS02195	COG1562	ergosterol biosynthetic process
ZZ6_RS02200	COG1215	transferase activity, transferring glycosyl groups
ZZ6_RS02205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZZ6_RS02215	COG0305	Participates in initiation and elongation during chromosome replication
ZZ6_RS02220	COG0295	cytidine deaminase activity
ZZ6_RS02225	COG0717	Belongs to the dCTP deaminase family
ZZ6_RS02230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZZ6_RS02235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZZ6_RS02245	COG1104	cysteine desulfurase activity
ZZ6_RS02255	COG1722	exodeoxyribonuclease VII activity
ZZ6_RS02260	COG0142	geranyltranstransferase activity
ZZ6_RS02265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZZ6_RS02275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZZ6_RS02280	COG0259	pyridoxamine-phosphate oxidase activity
ZZ6_RS02310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZZ6_RS02320	COG0018	arginyl-trna synthetase
ZZ6_RS02325	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZZ6_RS02330	COG0038	chloride channel
ZZ6_RS02340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZZ6_RS02345	COG0849	cell division
ZZ6_RS02350	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZZ6_RS02355	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZZ6_RS02360	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZZ6_RS02365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZZ6_RS02370	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZZ6_RS02380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZZ6_RS02385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZZ6_RS02395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZZ6_RS02410	COG0275	rRNA processing
ZZ6_RS02440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZZ6_RS02445	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZZ6_RS02450	COG0720	synthase
ZZ6_RS02465	COG1322	Protein conserved in bacteria
ZZ6_RS02470	COG0242	peptide deformylase activity
ZZ6_RS02475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZZ6_RS02480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZZ6_RS02485	COG0101	tRNA pseudouridine synthase activity
ZZ6_RS02490	COG1872	DUF167
ZZ6_RS02495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZZ6_RS02500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZZ6_RS02525	COG1129	ABC transporter
ZZ6_RS02525	COG0842	Transport permease protein
ZZ6_RS02530	COG0842	Transport permease protein
ZZ6_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_RS02550	COG1505	serine-type exopeptidase activity
ZZ6_RS02560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZZ6_RS02565	COG0540	Belongs to the ATCase OTCase family
ZZ6_RS02605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZZ6_RS02610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZZ6_RS02615	COG0154	amidase activity
ZZ6_RS02620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZZ6_RS02625	COG0583	DNA-binding transcription factor activity
ZZ6_RS02630	COG1538	Outer membrane efflux protein
ZZ6_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZZ6_RS02665	COG2239	Acts as a magnesium transporter
ZZ6_RS02670	COG0482	sulfurtransferase activity
ZZ6_RS02685	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ZZ6_RS02690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZZ6_RS02710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZZ6_RS02735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ZZ6_RS02750	COG0564	pseudouridine synthase activity
ZZ6_RS02755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZZ6_RS02790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZZ6_RS02800	COG2329	Antibiotic biosynthesis monooxygenase
ZZ6_RS02805	COG2022	thiamine diphosphate biosynthetic process
ZZ6_RS02810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZZ6_RS02815	COG0511	ligase activity, forming carbon-carbon bonds
ZZ6_RS02820	COG0439	Biotin carboxylase
ZZ6_RS02830	COG0456	acetyltransferase
ZZ6_RS02835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZZ6_RS02840	COG0085	RNA polymerase activity
ZZ6_RS02845	COG0222	ribosome binding
ZZ6_RS02850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZZ6_RS02855	COG0081	regulation of translation
ZZ6_RS02860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZZ6_RS02870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ZZ6_RS02880	COG3590	peptidase
ZZ6_RS02885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZZ6_RS02890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZZ6_RS02895	COG0741	lytic transglycosylase activity
ZZ6_RS02905	COG2326	polyphosphate kinase activity
ZZ6_RS02910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZZ6_RS02915	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ZZ6_RS02920	COG0248	Ppx GppA phosphatase
ZZ6_RS02925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZZ6_RS02945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZZ6_RS02950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZZ6_RS02955	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZZ6_RS02970	COG0318	PFAM AMP-dependent synthetase and ligase
ZZ6_RS02990	COG2076	Multidrug Resistance protein
ZZ6_RS03035	COG1764	response to oxidative stress
ZZ6_RS03040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZZ6_RS03045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZZ6_RS03050	COG0673	inositol 2-dehydrogenase activity
ZZ6_RS03105	COG0473	3-isopropylmalate dehydrogenase activity
ZZ6_RS03115	COG0583	DNA-binding transcription factor activity
ZZ6_RS03125	COG1381	Involved in DNA repair and RecF pathway recombination
ZZ6_RS03130	COG0322	excinuclease ABC activity
ZZ6_RS03135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZZ6_RS03140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZZ6_RS03150	COG0356	it plays a direct role in the translocation of protons across the membrane
ZZ6_RS03175	COG2003	Belongs to the UPF0758 family
ZZ6_RS03180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZZ6_RS03185	COG0484	heat shock protein binding
ZZ6_RS03190	COG0443	Heat shock 70 kDa protein
ZZ6_RS03205	COG3138	arginine N-succinyltransferase
ZZ6_RS03220	COG0726	polysaccharide deacetylase
ZZ6_RS03225	COG0628	permease
ZZ6_RS03240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZZ6_RS03250	COG1987	bacterial-type flagellum assembly
ZZ6_RS03270	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZZ6_RS03300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZZ6_RS03310	COG1677	Flagellar hook-basal body complex protein FliE
ZZ6_RS03340	COG0455	bacterial-type flagellum organization
ZZ6_RS03370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZZ6_RS03385	COG1558	bacterial-type flagellum-dependent cell motility
ZZ6_RS03390	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZZ6_RS03395	COG1749	Flagellar hook protein flgE
ZZ6_RS03410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ZZ6_RS03415	COG1706	bacterial-type flagellum-dependent cell motility
ZZ6_RS03430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZZ6_RS03440	COG1360	Flagellar Motor Protein
ZZ6_RS03455	COG0825	malonyl-CoA metabolic process
ZZ6_RS03460	COG4974	Belongs to the 'phage' integrase family
ZZ6_RS03470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZZ6_RS03475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZZ6_RS03490	COG1286	toxin biosynthetic process
ZZ6_RS03505	COG0284	orotidine-5'-phosphate decarboxylase activity
ZZ6_RS03510	COG0135	phosphoribosylanthranilate isomerase activity
ZZ6_RS03515	COG0133	tryptophan synthase activity
ZZ6_RS03520	COG0159	tryptophan synthase activity
ZZ6_RS03525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZZ6_RS03530	COG0285	dihydrofolate synthase activity
ZZ6_RS03535	COG2223	nitrite transmembrane transporter activity
ZZ6_RS03545	COG1301	dicarboxylic acid transport
ZZ6_RS03550	COG1187	pseudouridine synthase activity
ZZ6_RS03555	COG0742	ribosomal rna small subunit methyltransferase
ZZ6_RS03565	COG2999	glutathione oxidoreductase activity
ZZ6_RS03570	COG1116	anion transmembrane transporter activity
ZZ6_RS03575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZZ6_RS03585	COG2264	protein methyltransferase activity
ZZ6_RS03605	COG2814	Major facilitator Superfamily
ZZ6_RS03610	COG1643	Atp-dependent helicase
ZZ6_RS03615	COG0142	geranyltranstransferase activity
ZZ6_RS03620	COG0287	Prephenate dehydrogenase
ZZ6_RS03620	COG1605	Chorismate mutase
ZZ6_RS03625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZZ6_RS03635	COG2133	pyrroloquinoline quinone binding
ZZ6_RS03640	COG0779	Required for maturation of 30S ribosomal subunits
ZZ6_RS03655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZZ6_RS03655	COG3064	Membrane
ZZ6_RS03660	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZZ6_RS03665	COG1435	thymidine kinase activity
ZZ6_RS03670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZZ6_RS03675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZZ6_RS03680	COG1185	polyribonucleotide nucleotidyltransferase activity
ZZ6_RS03690	COG0038	chloride channel
ZZ6_RS03695	COG0659	secondary active sulfate transmembrane transporter activity
ZZ6_RS03705	COG0134	indole-3-glycerol-phosphate synthase activity
ZZ6_RS03710	COG0538	isocitrate dehydrogenase activity
ZZ6_RS03715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZZ6_RS03725	COG0203	ribosomal protein L17
ZZ6_RS03730	COG0202	RNA polymerase activity
ZZ6_RS03735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZZ6_RS03740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZZ6_RS03745	COG0563	adenylate kinase activity
ZZ6_RS03750	COG0201	protein transport
ZZ6_RS03755	COG0200	Binds to the 23S rRNA
ZZ6_RS03760	COG1841	ribosomal large subunit assembly
ZZ6_RS03765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZZ6_RS03770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZZ6_RS03775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZZ6_RS03780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZZ6_RS03785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZZ6_RS03790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZZ6_RS03795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZZ6_RS03800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZZ6_RS03805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZZ6_RS03810	COG0255	Belongs to the universal ribosomal protein uL29 family
ZZ6_RS03815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZZ6_RS03820	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZZ6_RS03825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZZ6_RS03830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZZ6_RS03835	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZZ6_RS03840	COG0089	rRNA binding
ZZ6_RS03845	COG0088	Forms part of the polypeptide exit tunnel
ZZ6_RS03850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZZ6_RS03855	COG0051	transcription antitermination factor activity, RNA binding
ZZ6_RS03860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZZ6_RS03865	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZZ6_RS03870	COG0049	tRNA binding
ZZ6_RS03875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZZ6_RS03880	COG0671	phosphoesterase, PA-phosphatase related
ZZ6_RS03885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZZ6_RS03890	COG1607	acyl-coa hydrolase
ZZ6_RS03895	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZZ6_RS03910	COG1956	GAF domain-containing protein
ZZ6_RS03920	COG0564	pseudouridine synthase activity
ZZ6_RS03925	COG0463	Glycosyl transferase, family 2
ZZ6_RS03945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZZ6_RS03950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZZ6_RS03955	COG0546	phosphoglycolate phosphatase activity
ZZ6_RS03975	COG0174	glutamine synthetase
ZZ6_RS03980	COG0347	Belongs to the P(II) protein family
ZZ6_RS03985	COG0006	proline dipeptidase activity
ZZ6_RS04015	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ZZ6_RS04020	COG1960	acyl-CoA dehydrogenase activity
ZZ6_RS04035	COG1494	fructose-1,6-bisphosphatase
ZZ6_RS04045	COG5002	protein histidine kinase activity
ZZ6_RS04065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZZ6_RS04065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZZ6_RS04080	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZZ6_RS04090	COG0583	DNA-binding transcription factor activity
ZZ6_RS04100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZZ6_RS04110	COG0149	triose-phosphate isomerase activity
ZZ6_RS04120	COG0504	CTP synthase activity
ZZ6_RS04130	COG0442	prolyl-tRNA aminoacylation
ZZ6_RS04140	COG1136	(ABC) transporter
ZZ6_RS04145	COG1522	sequence-specific DNA binding
ZZ6_RS04155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ZZ6_RS04160	COG1160	GTP binding
ZZ6_RS04190	COG1696	Membrane protein involved in D-alanine export
ZZ6_RS04205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZZ6_RS04205	COG1372	Participates in initiation and elongation during chromosome replication
ZZ6_RS04210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZZ6_RS04245	COG0194	GDP metabolic process
ZZ6_RS04250	COG2171	N-acyltransferase activity
ZZ6_RS04260	COG0316	Belongs to the HesB IscA family
ZZ6_RS04265	COG2151	metal-sulfur cluster biosynthetic enzyme
ZZ6_RS04270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZZ6_RS04275	COG0719	Fe-S assembly protein
ZZ6_RS04280	COG0396	ATPase activity
ZZ6_RS04285	COG0719	Fe-S assembly protein
ZZ6_RS04295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZZ6_RS04300	COG0287	Prephenate dehydrogenase
ZZ6_RS04320	COG2884	Cell division ATP-binding protein ftsE
ZZ6_RS04335	COG2095	MarC family integral membrane protein
ZZ6_RS04340	COG0187	DNA topoisomerase II activity
ZZ6_RS04350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZZ6_RS04355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZZ6_RS04365	COG0842	Transport permease protein
ZZ6_RS04380	COG0248	Ppx GppA phosphatase
ZZ6_RS04385	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ZZ6_RS04390	COG5001	Diguanylate cyclase
ZZ6_RS04505	COG1621	beta-fructofuranosidase activity
ZZ6_RS04510	COG1621	beta-fructofuranosidase activity
ZZ6_RS04520	COG1522	sequence-specific DNA binding
ZZ6_RS04525	COG1794	racemase activity, acting on amino acids and derivatives
ZZ6_RS04530	COG0837	glucose binding
ZZ6_RS04535	COG0129	dihydroxy-acid dehydratase activity
ZZ6_RS04540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZZ6_RS04545	COG0477	Major facilitator Superfamily
ZZ6_RS04550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZZ6_RS04555	COG0343	queuine tRNA-ribosyltransferase activity
ZZ6_RS04560	COG0556	nucleotide-excision repair
ZZ6_RS04570	COG0772	Belongs to the SEDS family
ZZ6_RS04595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZZ6_RS04620	COG1678	Uncharacterized ACR, COG1678
ZZ6_RS04625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZZ6_RS04630	COG1923	regulation of RNA biosynthetic process
ZZ6_RS04635	COG0004	ammonium transporteR
ZZ6_RS04645	COG0312	modulator of DNA gyrase
ZZ6_RS04655	COG0436	Aminotransferase
ZZ6_RS04675	COG1192	Involved in chromosome partitioning
ZZ6_RS04680	COG0352	thiamine-phosphate diphosphorylase activity
ZZ6_RS04685	COG3108	Peptidase M15
ZZ6_RS04695	COG0483	inositol monophosphate 1-phosphatase activity
ZZ6_RS04700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZZ6_RS04705	COG0626	cystathionine gamma-synthase activity
ZZ6_RS04710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZZ6_RS04720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZZ6_RS04725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZZ6_RS04730	COG0196	riboflavin kinase activity
ZZ6_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_RS04765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZZ6_RS04775	COG1473	amidohydrolase
ZZ6_RS04785	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_RS04805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZZ6_RS04820	COG1570	exodeoxyribonuclease VII activity
ZZ6_RS04825	COG0151	Belongs to the GarS family
ZZ6_RS04835	COG1253	flavin adenine dinucleotide binding
ZZ6_RS04840	COG0590	tRNA wobble adenosine to inosine editing
ZZ6_RS04845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZZ6_RS04850	COG2814	Major facilitator Superfamily
ZZ6_RS04855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZZ6_RS04860	COG2733	membrane
ZZ6_RS04885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZZ6_RS04895	COG1278	Cold shock
ZZ6_RS04915	COG1137	ATPase activity
ZZ6_RS04920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZZ6_RS04930	COG0277	FAD linked oxidase domain protein
ZZ6_RS04945	COG4133	protoheme IX ABC transporter activity
ZZ6_RS04950	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZZ6_RS04980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZZ6_RS04990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZZ6_RS05015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZZ6_RS05020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZZ6_RS05025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZZ6_RS05035	COG0776	regulation of translation
ZZ6_RS05045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZZ6_RS05050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZZ6_RS05055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZZ6_RS05060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZZ6_RS05065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZZ6_RS05075	COG0489	protein tyrosine kinase activity
ZZ6_RS05080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZZ6_RS05095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZZ6_RS05105	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZZ6_RS05110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZZ6_RS05120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZZ6_RS05120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZZ6_RS05125	COG4221	oxidoreductase activity
ZZ6_RS05130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZZ6_RS05135	COG2813	Specifically methylates the guanine in position
ZZ6_RS05135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZZ6_RS05155	COG1329	Transcriptional regulator
ZZ6_RS05160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ZZ6_RS05165	COG4581	dead DEAH box helicase
ZZ6_RS05170	COG0739	heme binding
ZZ6_RS05180	COG0534	Mate efflux family protein
ZZ6_RS05190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZZ6_RS05195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZZ6_RS05205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZZ6_RS05210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZZ6_RS05225	COG0789	Transcriptional regulator
ZZ6_RS05230	COG0840	transmembrane signaling receptor activity
ZZ6_RS05255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZZ6_RS05260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZZ6_RS05270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZZ6_RS05285	COG1530	ribonuclease E activity
ZZ6_RS05305	COG1760	l-serine dehydratase
ZZ6_RS05320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ZZ6_RS05325	COG0215	cysteine-tRNA ligase activity
ZZ6_RS05335	COG0488	(ABC) transporter
ZZ6_RS05340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZZ6_RS05345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZZ6_RS05350	COG1830	Aldolase
ZZ6_RS05360	COG0126	phosphoglycerate kinase activity
ZZ6_RS05365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZZ6_RS05390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZZ6_RS05400	COG0584	glycerophosphoryl diester phosphodiesterase
ZZ6_RS05405	COG2885	chlorophyll binding
ZZ6_RS05410	COG0823	Involved in the tonB-independent uptake of proteins
ZZ6_RS05420	COG0848	biopolymer transport protein
ZZ6_RS05425	COG0811	peptide transport
ZZ6_RS05430	COG0824	Thioesterase
ZZ6_RS05435	COG2255	four-way junction helicase activity
ZZ6_RS05440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZZ6_RS05450	COG0632	four-way junction helicase activity
ZZ6_RS05455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZZ6_RS05460	COG0217	transcriptional regulatory protein
ZZ6_RS05465	COG3750	Belongs to the UPF0335 family
ZZ6_RS05475	COG0469	pyruvate kinase activity
ZZ6_RS05490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZZ6_RS05510	COG1131	(ABC) transporter
ZZ6_RS05525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZZ6_RS05580	COG0671	phosphoesterase, PA-phosphatase related
ZZ6_RS05600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZZ6_RS05615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZZ6_RS05625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZZ6_RS05630	COG1151	hydroxylamine reductase activity
ZZ6_RS05635	COG1959	2 iron, 2 sulfur cluster binding
ZZ6_RS05640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZZ6_RS05645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZZ6_RS05645	COG0512	Glutamine amidotransferase of anthranilate synthase
ZZ6_RS05650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZZ6_RS05670	COG0488	(ABC) transporter
ZZ6_RS05675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ZZ6_RS05690	COG0463	Glycosyl transferase, family 2
ZZ6_RS05705	COG0066	3-isopropylmalate dehydratase activity
ZZ6_RS05710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZZ6_RS05715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZZ6_RS05760	COG2999	glutathione oxidoreductase activity
ZZ6_RS05775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZZ6_RS05780	COG1702	phosphate starvation-inducible protein PhoH
ZZ6_RS05785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZZ6_RS05790	COG0835	chemotaxis
ZZ6_RS05795	COG0745	RESPONSE REGULATOR receiver
ZZ6_RS05800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ZZ6_RS05805	COG2201	protein-glutamate methylesterase activity
ZZ6_RS05810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZZ6_RS05815	COG2198	Histidine kinase
ZZ6_RS05815	COG0643	Histidine kinase
ZZ6_RS05825	COG0840	transmembrane signaling receptor activity
ZZ6_RS05850	COG1028	Short-chain dehydrogenase reductase Sdr
ZZ6_RS05860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZZ6_RS05870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZZ6_RS05930	COG1929	Belongs to the glycerate kinase type-1 family
ZZ6_RS05945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZZ6_RS05950	COG0730	response to heat
ZZ6_RS05955	COG1846	Transcriptional regulator
ZZ6_RS05965	COG2807	transmembrane transport
ZZ6_RS05980	COG0424	maF-like protein
ZZ6_RS05990	COG0237	dephospho-CoA kinase activity
ZZ6_RS05995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZZ6_RS06000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ZZ6_RS06005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZZ6_RS06020	COG2983	Belongs to the UPF0260 family
ZZ6_RS06040	COG1715	Restriction endonuclease
ZZ6_RS06045	COG0138	bifunctional purine biosynthesis protein purh
ZZ6_RS06055	COG0247	lactate metabolic process
ZZ6_RS06060	COG1139	Iron-sulfur cluster binding protein
ZZ6_RS06075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZZ6_RS06085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZZ6_RS06090	COG1420	regulation of RNA biosynthetic process
ZZ6_RS06095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZZ6_RS06100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZZ6_RS06105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZZ6_RS06120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZZ6_RS06125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZZ6_RS06130	COG0175	sulfate reduction
ZZ6_RS06135	COG1648	precorrin-2 dehydrogenase activity
ZZ6_RS06135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZZ6_RS06140	COG0175	sulfate reduction
ZZ6_RS06180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZZ6_RS06190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ZZ6_RS06205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZZ6_RS06210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZZ6_RS06225	COG0445	tRNA wobble uridine modification
ZZ6_RS06230	COG0357	Ribosomal RNA small subunit methyltransferase G
ZZ6_RS06245	COG0477	Major facilitator Superfamily
ZZ6_RS06255	COG2423	ornithine cyclodeaminase activity
ZZ6_RS06275	COG0658	competence protein
ZZ6_RS06275	COG2333	competence protein COMEC
ZZ6_RS06280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZZ6_RS06285	COG0372	Belongs to the citrate synthase family
ZZ6_RS06290	COG5002	protein histidine kinase activity
ZZ6_RS06315	COG0438	transferase activity, transferring glycosyl groups
ZZ6_RS06315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZZ6_RS06320	COG0497	DNA recombination
ZZ6_RS06325	COG0281	malic enzyme
ZZ6_RS06330	COG0459	protein refolding
ZZ6_RS06335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZZ6_RS06340	COG0616	signal peptide processing
ZZ6_RS06345	COG0826	peptidase U32
ZZ6_RS06355	COG1368	sulfuric ester hydrolase activity
ZZ6_RS06390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZZ6_RS06395	COG0156	8-amino-7-oxononanoate synthase activity
ZZ6_RS06405	COG4106	trans-aconitate 2-methyltransferase activity
ZZ6_RS06405	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZZ6_RS06415	COG0189	ligase activity
ZZ6_RS06420	COG0012	GTP binding
ZZ6_RS06425	COG0193	aminoacyl-tRNA hydrolase activity
ZZ6_RS06430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZZ6_RS06445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZZ6_RS06450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZZ6_RS06455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZZ6_RS06460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZZ6_RS06465	COG0181	hydroxymethylbilane synthase activity
ZZ6_RS06480	COG0416	fatty acid biosynthetic process
ZZ6_RS06485	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZZ6_RS06495	COG1862	Preprotein translocase
ZZ6_RS06500	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZZ6_RS06510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZZ6_RS06530	COG0612	Peptidase, M16
ZZ6_RS06545	COG1335	isochorismatase
ZZ6_RS06550	COG3180	Ammonia monooxygenase
ZZ6_RS06555	COG1902	pentaerythritol trinitrate reductase activity
ZZ6_RS06560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZZ6_RS06565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZZ6_RS06570	COG3180	Ammonia monooxygenase
ZZ6_RS06585	COG0113	porphobilinogen synthase activity
ZZ6_RS06590	COG0525	valine-tRNA ligase activity
ZZ6_RS06615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ZZ6_RS06625	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ZZ6_RS06645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZZ6_RS06695	COG3293	Transposase
ZZ6_RS06765	COG0716	FMN binding
ZZ6_RS06790	COG1120	ATPase activity
ZZ6_RS06795	COG2824	Alkylphosphonate utilization operon protein PhnA
ZZ6_RS06800	COG0673	inositol 2-dehydrogenase activity
ZZ6_RS06820	COG3585	molybdate ion transport
ZZ6_RS06825	COG0157	Belongs to the NadC ModD family
ZZ6_RS06835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZZ6_RS06850	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ZZ6_RS06855	COG4774	siderophore transport
ZZ6_RS06865	COG5554	nitrogen fixation
ZZ6_RS06875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZZ6_RS06880	COG0535	radical SAM domain protein
ZZ6_RS06890	COG4657	Part of a membrane complex involved in electron transport
ZZ6_RS06900	COG4656	Part of a membrane complex involved in electron transport
ZZ6_RS06905	COG4658	electron transport chain
ZZ6_RS06925	COG0546	phosphoglycolate phosphatase activity
ZZ6_RS06930	COG0531	amino acid
ZZ6_RS06935	COG0776	regulation of translation
ZZ6_RS06945	COG0539	negative regulation of cytoplasmic translation
ZZ6_RS06950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZZ6_RS06955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZZ6_RS06985	COG0129	dihydroxy-acid dehydratase activity
ZZ6_RS06995	COG1132	(ABC) transporter
ZZ6_RS07060	COG0656	L-ascorbic acid biosynthetic process
ZZ6_RS07065	COG3321	synthase
ZZ6_RS07065	COG0604	alcohol dehydrogenase
ZZ6_RS07070	COG1979	alcohol dehydrogenase
ZZ6_RS07075	COG0165	Argininosuccinate lyase
ZZ6_RS07085	COG0019	diaminopimelate decarboxylase activity
ZZ6_RS07090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZZ6_RS07100	COG2989	Protein conserved in bacteria
ZZ6_RS07110	COG0792	nuclease activity
ZZ6_RS07115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZZ6_RS07130	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZZ6_RS07135	COG3265	gluconokinase activity
ZZ6_RS07140	COG2610	gluconate transmembrane transporter activity
ZZ6_RS07145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZZ6_RS07150	COG1012	belongs to the aldehyde dehydrogenase family
ZZ6_RS07175	COG2853	Lipoprotein
ZZ6_RS07195	COG0646	methionine synthase
ZZ6_RS07195	COG1410	methionine synthase
ZZ6_RS07205	COG0481	GTPase activity
ZZ6_RS07215	COG3275	phosphorelay sensor kinase activity
ZZ6_RS07220	COG3279	Response regulator of the LytR AlgR family
ZZ6_RS07235	COG0583	DNA-binding transcription factor activity
ZZ6_RS07245	COG1045	serine acetyltransferase
ZZ6_RS07260	COG0436	Aminotransferase
ZZ6_RS07265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ZZ6_RS07270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZZ6_RS07285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ZZ6_RS07295	COG1758	RNA polymerase activity
ZZ6_RS07300	COG1940	carbohydrate kinase activity
ZZ6_RS07330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZZ6_RS07340	COG0628	permease
ZZ6_RS07345	COG0681	Belongs to the peptidase S26 family
ZZ6_RS07350	COG0736	holo-[acyl-carrier-protein] synthase activity
ZZ6_RS07355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZZ6_RS07360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZZ6_RS07375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZZ6_RS07380	COG1674	ftsk spoiiie
ZZ6_RS07385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ZZ6_RS07395	COG0708	Exodeoxyribonuclease III
ZZ6_RS07405	COG1733	regulation of RNA biosynthetic process
ZZ6_RS07410	COG1064	alcohol dehydrogenase
ZZ6_RS07425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZZ6_RS07430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZZ6_RS07435	COG1295	ribonuclease BN
ZZ6_RS07440	COG0484	heat shock protein binding
ZZ6_RS07445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZZ6_RS07455	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZZ6_RS07465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZZ6_RS07475	COG0252	asparaginase activity
ZZ6_RS07485	COG2985	domain, Protein
ZZ6_RS07500	COG0077	Prephenate dehydratase
ZZ6_RS07505	COG1194	a g-specific adenine glycosylase
ZZ6_RS07520	COG0656	L-ascorbic acid biosynthetic process
ZZ6_RS07540	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ZZ6_RS07550	COG0793	Belongs to the peptidase S41A family
ZZ6_RS07560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZZ6_RS07565	COG0799	negative regulation of ribosome biogenesis
ZZ6_RS07570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZZ6_RS07575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZZ6_RS07590	COG0037	tRNA processing
ZZ6_RS07610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ZZ6_RS07625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ZZ6_RS07635	COG3386	PFAM SMP-30 Gluconolaconase
ZZ6_RS07640	COG1573	uracil-dna glycosylase
ZZ6_RS07645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ZZ6_RS07655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZZ6_RS07665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZZ6_RS07670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ZZ6_RS07680	COG0180	Tryptophanyl-tRNA synthetase
ZZ6_RS07690	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ZZ6_RS07705	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ZZ6_RS07720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZZ6_RS07725	COG4774	siderophore transport
ZZ6_RS07745	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZZ6_RS07750	COG0706	membrane insertase activity
ZZ6_RS07755	COG0594	ribonuclease P activity
ZZ6_RS07765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZZ6_RS07780	COG0505	Belongs to the CarA family
ZZ6_RS07790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZZ6_RS07820	COG0148	phosphopyruvate hydratase activity
ZZ6_RS07830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZZ6_RS07835	COG0022	dehydrogenase e1 component
ZZ6_RS07835	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZZ6_RS07845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZZ6_RS07845	COG3453	Protein conserved in bacteria
ZZ6_RS07850	COG0328	RNA-DNA hybrid ribonuclease activity
ZZ6_RS07855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZZ6_RS07865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZZ6_RS07870	COG1454	alcohol dehydrogenase
ZZ6_RS07885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZZ6_RS07890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZZ6_RS07895	COG1127	ABC transporter
ZZ6_RS07905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZZ6_RS07920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZZ6_RS07980	COG1294	oxidase, subunit
ZZ6_RS07985	COG1271	oxidase subunit
ZZ6_RS08000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZZ6_RS08015	COG1742	UPF0060 membrane protein
ZZ6_RS08035	COG1051	belongs to the nudix hydrolase family
ZZ6_RS08040	COG4221	oxidoreductase activity
ZZ6_RS08045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZZ6_RS08060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZZ6_RS08065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZZ6_RS08070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZZ6_RS08075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZZ6_RS08085	COG1657	PFAM Prenyltransferase squalene oxidase
ZZ6_RS08110	COG0629	single-stranded DNA binding
ZZ6_RS08145	COG0047	phosphoribosylformylglycinamidine synthase activity
ZZ6_RS08150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZZ6_RS08155	COG0517	IMP dehydrogenase activity
ZZ6_RS08155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZZ6_RS08160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZZ6_RS08175	COG1538	Outer membrane efflux protein
ZZ6_RS08185	COG4771	TonB-dependent receptor
ZZ6_RS08200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZZ6_RS08210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZZ6_RS08215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZZ6_RS08220	COG0072	phenylalanine-tRNA ligase activity
ZZ6_RS08220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZZ6_RS08225	COG5265	(ABC) transporter
ZZ6_RS08235	COG2890	protein-(glutamine-N5) methyltransferase activity
ZZ6_RS08240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZZ6_RS08245	COG0124	histidyl-tRNA synthetase
ZZ6_RS08250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZZ6_RS08270	COG0131	Imidazoleglycerol-phosphate dehydratase
ZZ6_RS08275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZZ6_RS08280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZZ6_RS08285	COG0107	imidazoleglycerol-phosphate synthase activity
ZZ6_RS08290	COG0140	phosphoribosyl-ATP diphosphatase activity
ZZ6_RS08300	COG0531	amino acid
ZZ6_RS08305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZZ6_RS08310	COG2096	Adenosyltransferase
ZZ6_RS08315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZZ6_RS08340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZZ6_RS08345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZZ6_RS08350	COG2199	diguanylate cyclase activity
ZZ6_RS08350	COG2200	EAL domain
ZZ6_RS08380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZZ6_RS08400	COG0045	succinate-CoA ligase (ADP-forming) activity
ZZ6_RS08415	COG0363	glucosamine-6-phosphate deaminase activity
ZZ6_RS08440	COG1217	gtp-binding protein TYPA
ZZ6_RS08455	COG0814	amino acid
ZZ6_RS08495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ZZ6_RS08500	COG2814	Major facilitator Superfamily
ZZ6_RS08530	COG0752	glycyl-tRNA synthetase alpha subunit
ZZ6_RS08540	COG2244	polysaccharide biosynthetic process
ZZ6_RS08560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZZ6_RS08580	COG0495	leucyl-tRNA aminoacylation
ZZ6_RS08615	COG1597	lipid kinase activity
ZZ6_RS08620	COG2003	Belongs to the UPF0758 family
ZZ6_RS08625	COG0352	thiamine-phosphate diphosphorylase activity
ZZ6_RS08635	COG0612	Peptidase, M16
ZZ6_RS08640	COG0612	Peptidase, M16
ZZ6_RS08645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZZ6_RS08650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZZ6_RS08655	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ZZ6_RS08660	COG0513	Belongs to the DEAD box helicase family
ZZ6_RS08675	COG1214	PFAM Peptidase M22, glycoprotease
ZZ6_RS08685	COG4957	zinc ion binding
ZZ6_RS08695	COG2193	ferroxidase activity
ZZ6_RS08715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZZ6_RS08720	COG0596	Alpha beta hydrolase
ZZ6_RS08725	COG0784	Response regulator, receiver
ZZ6_RS08735	COG0739	heme binding
ZZ6_RS08740	COG0316	Belongs to the HesB IscA family
ZZ6_RS08745	COG0708	Exodeoxyribonuclease III
ZZ6_RS08805	COG0405	Gamma-glutamyltransferase
ZZ6_RS08825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZZ6_RS08830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZZ6_RS08860	COG0571	ribonuclease III activity
ZZ6_RS08870	COG0300	oxidoreductase activity
ZZ6_RS08890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZZ6_RS08895	COG3706	GGDEF domain
ZZ6_RS08900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZZ6_RS08920	COG3961	Belongs to the TPP enzyme family
ZZ6_RS08925	COG0268	Binds directly to 16S ribosomal RNA
ZZ6_RS09085	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZZ6_RS09085	COG2885	chlorophyll binding
ZZ6_RS09120	COG0308	aminopeptidase N
ZZ6_RS09185	COG0024	Methionine aminopeptidase