locus-tag	class	description
ZA10_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZA10_RS00010	COG0488	(ABC) transporter
ZA10_RS00015	COG2885	chlorophyll binding
ZA10_RS00015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZA10_RS00020	COG4702	Belongs to the UPF0303 family
ZA10_RS00025	COG0670	Belongs to the BI1 family
ZA10_RS00035	COG1546	Belongs to the CinA family
ZA10_RS00035	COG1058	Belongs to the CinA family
ZA10_RS00040	COG0024	Methionine aminopeptidase
ZA10_RS00055	COG0308	aminopeptidase N
ZA10_RS00075	COG2321	neutral zinc metallopeptidase
ZA10_RS00085	COG1280	lysine exporter protein (LysE YggA)
ZA10_RS00090	COG1741	Belongs to the pirin family
ZA10_RS00095	COG0583	DNA-binding transcription factor activity
ZA10_RS00100	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZA10_RS00105	COG2353	YceI-like domain
ZA10_RS00110	COG0668	transmembrane transport
ZA10_RS00115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZA10_RS00120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZA10_RS00135	COG1660	Displays ATPase and GTPase activities
ZA10_RS00140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZA10_RS00145	COG0642	Histidine kinase
ZA10_RS00150	COG0745	RESPONSE REGULATOR receiver
ZA10_RS00160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZA10_RS00170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZA10_RS00175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZA10_RS00180	COG2244	polysaccharide biosynthetic process
ZA10_RS00190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZA10_RS00195	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZA10_RS00200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZA10_RS00205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ZA10_RS00210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZA10_RS00220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ZA10_RS00220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ZA10_RS00225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZA10_RS00240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZA10_RS00245	COG0321	lipoyl(octanoyl) transferase activity
ZA10_RS00265	COG0602	queuosine metabolic process
ZA10_RS00270	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZA10_RS00285	COG2261	transglycosylase associated protein
ZA10_RS00290	COG2223	nitrite transmembrane transporter activity
ZA10_RS00315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZA10_RS00320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZA10_RS00325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZA10_RS00335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZA10_RS00345	COG1012	belongs to the aldehyde dehydrogenase family
ZA10_RS00350	COG1648	precorrin-2 dehydrogenase activity
ZA10_RS00350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZA10_RS00355	COG0156	8-amino-7-oxononanoate synthase activity
ZA10_RS00370	COG0519	Catalyzes the synthesis of GMP from XMP
ZA10_RS00370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZA10_RS00380	COG4948	Mandelate Racemase Muconate Lactonizing
ZA10_RS00385	COG1116	anion transmembrane transporter activity
ZA10_RS00390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZA10_RS00395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ZA10_RS00400	COG4771	TonB-dependent receptor
ZA10_RS00405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZA10_RS00410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ZA10_RS00415	COG1138	Cytochrome C-type biogenesis protein
ZA10_RS00420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZA10_RS00425	COG3088	subunit of a heme lyase
ZA10_RS00455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZA10_RS00465	COG2866	Carboxypeptidase
ZA10_RS00470	COG0588	phosphoglycerate mutase activity
ZA10_RS00475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZA10_RS00480	COG1064	alcohol dehydrogenase
ZA10_RS00490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZA10_RS00530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZA10_RS00530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZA10_RS00535	COG0302	gtp cyclohydrolase
ZA10_RS00540	COG4948	Mandelate Racemase Muconate Lactonizing
ZA10_RS00545	COG0359	binds to the 23S rRNA
ZA10_RS00550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZA10_RS00555	COG0360	Binds together with S18 to 16S ribosomal RNA
ZA10_RS00565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZA10_RS00580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZA10_RS00585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZA10_RS00590	COG0805	protein transport
ZA10_RS00610	COG0513	Belongs to the DEAD box helicase family
ZA10_RS00620	COG0166	Belongs to the GPI family
ZA10_RS00635	COG3158	transport of potassium into the cell
ZA10_RS00645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZA10_RS00665	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZA10_RS00670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZA10_RS00680	COG0156	8-amino-7-oxononanoate synthase activity
ZA10_RS00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZA10_RS00690	COG2814	Major facilitator Superfamily
ZA10_RS00695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ZA10_RS00700	COG0758	DNA mediated transformation
ZA10_RS00705	COG1754	DNA topoisomerase type I activity
ZA10_RS00705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZA10_RS00710	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZA10_RS00715	COG0756	dUTP diphosphatase activity
ZA10_RS00720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZA10_RS00725	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZA10_RS00730	COG2226	methyltransferase
ZA10_RS00740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZA10_RS00765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZA10_RS00780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZA10_RS00785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZA10_RS00795	COG2205	protein histidine kinase activity
ZA10_RS00810	COG3724	N-succinylarginine dihydrolase activity
ZA10_RS00815	COG1472	Belongs to the glycosyl hydrolase 3 family
ZA10_RS00825	COG2971	BadF BadG BcrA BcrD
ZA10_RS00835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZA10_RS00840	COG1040	competence protein
ZA10_RS00845	COG0745	RESPONSE REGULATOR receiver
ZA10_RS00850	COG0704	Plays a role in the regulation of phosphate uptake
ZA10_RS00860	COG0688	phosphatidylethanolamine metabolic process
ZA10_RS00865	COG1183	phosphatidylcholine synthase activity
ZA10_RS00870	COG1794	racemase activity, acting on amino acids and derivatives
ZA10_RS00880	COG0052	Belongs to the universal ribosomal protein uS2 family
ZA10_RS00885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZA10_RS00890	COG0528	UMP kinase activity
ZA10_RS00895	COG0233	cytoplasmic translational termination
ZA10_RS00900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZA10_RS00905	COG0575	Belongs to the CDS family
ZA10_RS00910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZA10_RS00915	COG0750	zinc metalloprotease
ZA10_RS00920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZA10_RS00930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZA10_RS00935	COG0254	rRNA binding
ZA10_RS00950	COG0492	ferredoxin-NADP+ reductase activity
ZA10_RS00955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZA10_RS00960	COG0440	acetolactate synthase activity
ZA10_RS00965	COG0028	Belongs to the TPP enzyme family
ZA10_RS00970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZA10_RS00980	COG1858	cytochrome C peroxidase
ZA10_RS00985	COG0312	modulator of DNA gyrase
ZA10_RS00995	COG0288	reversible hydration of carbon dioxide
ZA10_RS01000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZA10_RS01005	COG2867	negative regulation of translational initiation
ZA10_RS01010	COG1058	Belongs to the CinA family
ZA10_RS01010	COG1546	Belongs to the CinA family
ZA10_RS01020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZA10_RS01020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZA10_RS01030	COG2204	response regulator
ZA10_RS01035	COG5000	phosphorelay sensor kinase activity
ZA10_RS01040	COG2204	response regulator
ZA10_RS01050	COG0776	regulation of translation
ZA10_RS01075	COG1968	undecaprenyl-diphosphatase activity
ZA10_RS01085	COG1573	uracil-dna glycosylase
ZA10_RS01090	COG1252	NADH dehydrogenase
ZA10_RS01095	COG2917	probably involved in intracellular septation
ZA10_RS01100	COG2807	transmembrane transport
ZA10_RS01110	COG1522	sequence-specific DNA binding
ZA10_RS01125	COG2205	protein histidine kinase activity
ZA10_RS01130	COG0802	atpase or kinase
ZA10_RS01135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ZA10_RS01145	COG1074	ATP-dependent DNA helicase activity
ZA10_RS01155	COG0557	exoribonuclease II activity
ZA10_RS01160	COG3956	TIGRFAM MazG family protein
ZA10_RS01170	COG0084	hydrolase, TatD family'
ZA10_RS01180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZA10_RS01185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZA10_RS01190	COG1686	Belongs to the peptidase S11 family
ZA10_RS01200	COG2951	lytic endotransglycosylase activity
ZA10_RS01205	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ZA10_RS01210	COG0457	Tetratricopeptide repeat
ZA10_RS01215	COG1215	transferase activity, transferring glycosyl groups
ZA10_RS01220	COG1215	transferase activity, transferring glycosyl groups
ZA10_RS01235	COG0335	large ribosomal subunit rRNA binding
ZA10_RS01240	COG0336	Belongs to the RNA methyltransferase TrmD family
ZA10_RS01245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZA10_RS01250	COG0228	four-way junction DNA binding
ZA10_RS01255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZA10_RS01260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZA10_RS01265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZA10_RS01270	COG0552	protein localization to endoplasmic reticulum
ZA10_RS01275	COG0484	heat shock protein binding
ZA10_RS01305	COG1842	Phage shock protein A
ZA10_RS01315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZA10_RS01335	COG0617	tRNA 3'-terminal CCA addition
ZA10_RS01340	COG5001	Diguanylate cyclase
ZA10_RS01345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZA10_RS01350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZA10_RS01355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZA10_RS01360	COG0581	inorganic phosphate transmembrane transporter activity
ZA10_RS01365	COG0573	inorganic phosphate transmembrane transporter activity
ZA10_RS01370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZA10_RS01380	COG1970	mechanosensitive ion channel activity
ZA10_RS01390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ZA10_RS01410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZA10_RS01420	COG0137	argininosuccinate synthase activity
ZA10_RS01430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ZA10_RS01435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZA10_RS01465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZA10_RS01470	COG1104	cysteine desulfurase activity
ZA10_RS01475	COG2945	thiolester hydrolase activity
ZA10_RS01480	COG0019	diaminopimelate decarboxylase activity
ZA10_RS01490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZA10_RS01495	COG1127	ABC transporter
ZA10_RS01510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZA10_RS01515	COG0424	maF-like protein
ZA10_RS01525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ZA10_RS01545	COG0277	FAD linked oxidase domain protein
ZA10_RS01550	COG3781	membrane
ZA10_RS01555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZA10_RS01565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZA10_RS01570	COG0351	phosphomethylpyrimidine kinase
ZA10_RS01570	COG0352	thiamine-phosphate diphosphorylase activity
ZA10_RS01575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZA10_RS01580	COG3104	oligopeptide transport
ZA10_RS01585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZA10_RS01590	COG0009	L-threonylcarbamoyladenylate synthase
ZA10_RS01595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZA10_RS01600	COG0800	Aldolase
ZA10_RS01605	COG0668	transmembrane transport
ZA10_RS01620	COG0071	Belongs to the small heat shock protein (HSP20) family
ZA10_RS01635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZA10_RS01640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZA10_RS01655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZA10_RS01660	COG4172	Belongs to the ABC transporter superfamily
ZA10_RS01670	COG4206	TonB-dependent receptor
ZA10_RS01680	COG0667	Aldo Keto reductase
ZA10_RS01710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZA10_RS01720	COG2252	PERMEase
ZA10_RS01730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZA10_RS01735	COG2814	Major facilitator Superfamily
ZA10_RS01740	COG1566	PFAM secretion protein HlyD family protein
ZA10_RS01755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ZA10_RS01775	COG2857	Cytochrome c1
ZA10_RS01780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZA10_RS01785	COG0723	plastoquinol--plastocyanin reductase activity
ZA10_RS01795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZA10_RS01800	COG0408	coproporphyrinogen oxidase activity
ZA10_RS01810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZA10_RS01815	COG0740	serine-type endopeptidase activity
ZA10_RS01825	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZA10_RS01845	COG1621	beta-fructofuranosidase activity
ZA10_RS01860	COG1846	Transcriptional regulator
ZA10_RS01865	COG0402	S-adenosylhomocysteine deaminase activity
ZA10_RS01870	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ZA10_RS01875	COG1448	Aminotransferase
ZA10_RS01880	COG0697	spore germination
ZA10_RS01910	COG3191	aminopeptidase activity
ZA10_RS01915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZA10_RS01925	COG1278	Cold shock
ZA10_RS01930	COG0653	protein targeting
ZA10_RS01935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZA10_RS01975	COG2217	Heavy metal translocating P-type atpase
ZA10_RS01980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZA10_RS01985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZA10_RS02025	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZA10_RS02035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZA10_RS02050	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZA10_RS02050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZA10_RS02085	COG1199	ATP-dependent helicase activity
ZA10_RS02090	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZA10_RS02115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZA10_RS02120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZA10_RS02125	COG0840	transmembrane signaling receptor activity
ZA10_RS02130	COG2198	Histidine kinase
ZA10_RS02130	COG0643	Histidine kinase
ZA10_RS02135	COG2201	protein-glutamate methylesterase activity
ZA10_RS02150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZA10_RS02165	COG1657	PFAM Prenyltransferase squalene oxidase
ZA10_RS02170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ZA10_RS02175	COG1562	ergosterol biosynthetic process
ZA10_RS02180	COG1562	ergosterol biosynthetic process
ZA10_RS02185	COG1215	transferase activity, transferring glycosyl groups
ZA10_RS02190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZA10_RS02200	COG0305	Participates in initiation and elongation during chromosome replication
ZA10_RS02205	COG0295	cytidine deaminase activity
ZA10_RS02210	COG0717	Belongs to the dCTP deaminase family
ZA10_RS02215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZA10_RS02220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZA10_RS02230	COG1104	cysteine desulfurase activity
ZA10_RS02240	COG1722	exodeoxyribonuclease VII activity
ZA10_RS02245	COG0142	geranyltranstransferase activity
ZA10_RS02250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZA10_RS02260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZA10_RS02265	COG0259	pyridoxamine-phosphate oxidase activity
ZA10_RS02290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZA10_RS02300	COG0018	arginyl-trna synthetase
ZA10_RS02305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZA10_RS02310	COG0038	chloride channel
ZA10_RS02320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZA10_RS02325	COG0849	cell division
ZA10_RS02330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZA10_RS02335	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZA10_RS02340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZA10_RS02345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZA10_RS02350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZA10_RS02360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZA10_RS02365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZA10_RS02375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZA10_RS02390	COG0275	rRNA processing
ZA10_RS02410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZA10_RS02415	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZA10_RS02420	COG0720	synthase
ZA10_RS02435	COG1322	Protein conserved in bacteria
ZA10_RS02440	COG0242	peptide deformylase activity
ZA10_RS02445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZA10_RS02450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZA10_RS02455	COG0101	tRNA pseudouridine synthase activity
ZA10_RS02460	COG1872	DUF167
ZA10_RS02465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZA10_RS02470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZA10_RS02500	COG0842	Transport permease protein
ZA10_RS02500	COG1129	ABC transporter
ZA10_RS02505	COG0842	Transport permease protein
ZA10_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS02525	COG1505	serine-type exopeptidase activity
ZA10_RS02535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZA10_RS02540	COG0540	Belongs to the ATCase OTCase family
ZA10_RS02565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZA10_RS02570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZA10_RS02575	COG0154	amidase activity
ZA10_RS02580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZA10_RS02585	COG0583	DNA-binding transcription factor activity
ZA10_RS02590	COG1538	Outer membrane efflux protein
ZA10_RS02605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZA10_RS02625	COG2239	Acts as a magnesium transporter
ZA10_RS02630	COG0482	sulfurtransferase activity
ZA10_RS02645	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ZA10_RS02650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZA10_RS02670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZA10_RS02695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ZA10_RS02710	COG0564	pseudouridine synthase activity
ZA10_RS02715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZA10_RS02750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZA10_RS02760	COG2329	Antibiotic biosynthesis monooxygenase
ZA10_RS02765	COG2022	thiamine diphosphate biosynthetic process
ZA10_RS02770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZA10_RS02775	COG0511	ligase activity, forming carbon-carbon bonds
ZA10_RS02780	COG0439	Biotin carboxylase
ZA10_RS02795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZA10_RS02800	COG0085	RNA polymerase activity
ZA10_RS02810	COG0222	ribosome binding
ZA10_RS02815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZA10_RS02820	COG0081	regulation of translation
ZA10_RS02825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZA10_RS02835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ZA10_RS02845	COG3590	peptidase
ZA10_RS02850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZA10_RS02855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZA10_RS02860	COG0741	lytic transglycosylase activity
ZA10_RS02870	COG2326	polyphosphate kinase activity
ZA10_RS02875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZA10_RS02880	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ZA10_RS02885	COG0248	Ppx GppA phosphatase
ZA10_RS02890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZA10_RS02905	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZA10_RS02910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZA10_RS02915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZA10_RS02930	COG0318	PFAM AMP-dependent synthetase and ligase
ZA10_RS02950	COG2076	Multidrug Resistance protein
ZA10_RS02980	COG1764	response to oxidative stress
ZA10_RS02985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZA10_RS02990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZA10_RS02995	COG0673	inositol 2-dehydrogenase activity
ZA10_RS03000	COG0679	Auxin Efflux Carrier
ZA10_RS03050	COG0473	3-isopropylmalate dehydrogenase activity
ZA10_RS03060	COG0583	DNA-binding transcription factor activity
ZA10_RS03070	COG1381	Involved in DNA repair and RecF pathway recombination
ZA10_RS03075	COG0322	excinuclease ABC activity
ZA10_RS03080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZA10_RS03085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZA10_RS03095	COG0356	it plays a direct role in the translocation of protons across the membrane
ZA10_RS03120	COG2003	Belongs to the UPF0758 family
ZA10_RS03125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZA10_RS03130	COG0484	heat shock protein binding
ZA10_RS03135	COG0443	Heat shock 70 kDa protein
ZA10_RS03150	COG3138	arginine N-succinyltransferase
ZA10_RS03165	COG0726	polysaccharide deacetylase
ZA10_RS03170	COG0628	permease
ZA10_RS03185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZA10_RS03190	COG1684	flagellar biosynthetic protein fliR
ZA10_RS03195	COG1987	bacterial-type flagellum assembly
ZA10_RS03215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZA10_RS03245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZA10_RS03255	COG1677	Flagellar hook-basal body complex protein FliE
ZA10_RS03265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZA10_RS03285	COG0455	bacterial-type flagellum organization
ZA10_RS03315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZA10_RS03330	COG1558	bacterial-type flagellum-dependent cell motility
ZA10_RS03335	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZA10_RS03340	COG1749	Flagellar hook protein flgE
ZA10_RS03355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ZA10_RS03360	COG1706	bacterial-type flagellum-dependent cell motility
ZA10_RS03385	COG1360	Flagellar Motor Protein
ZA10_RS03400	COG0825	malonyl-CoA metabolic process
ZA10_RS03405	COG4974	Belongs to the 'phage' integrase family
ZA10_RS03415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZA10_RS03420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZA10_RS03435	COG1286	toxin biosynthetic process
ZA10_RS03450	COG0284	orotidine-5'-phosphate decarboxylase activity
ZA10_RS03455	COG0135	phosphoribosylanthranilate isomerase activity
ZA10_RS03460	COG0133	tryptophan synthase activity
ZA10_RS03465	COG0159	tryptophan synthase activity
ZA10_RS03470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZA10_RS03480	COG2223	nitrite transmembrane transporter activity
ZA10_RS03490	COG1301	dicarboxylic acid transport
ZA10_RS03495	COG1187	pseudouridine synthase activity
ZA10_RS03500	COG0742	ribosomal rna small subunit methyltransferase
ZA10_RS03510	COG2999	glutathione oxidoreductase activity
ZA10_RS03515	COG1116	anion transmembrane transporter activity
ZA10_RS03520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZA10_RS03530	COG2264	protein methyltransferase activity
ZA10_RS03550	COG2814	Major facilitator Superfamily
ZA10_RS03560	COG1643	Atp-dependent helicase
ZA10_RS03565	COG0142	geranyltranstransferase activity
ZA10_RS03570	COG1605	Chorismate mutase
ZA10_RS03570	COG0287	Prephenate dehydrogenase
ZA10_RS03575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZA10_RS03585	COG2133	pyrroloquinoline quinone binding
ZA10_RS03590	COG0779	Required for maturation of 30S ribosomal subunits
ZA10_RS03605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZA10_RS03605	COG3064	Membrane
ZA10_RS03610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZA10_RS03615	COG1435	thymidine kinase activity
ZA10_RS03620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZA10_RS03625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZA10_RS03630	COG1185	polyribonucleotide nucleotidyltransferase activity
ZA10_RS03640	COG0038	chloride channel
ZA10_RS03645	COG0659	secondary active sulfate transmembrane transporter activity
ZA10_RS03655	COG0134	indole-3-glycerol-phosphate synthase activity
ZA10_RS03660	COG0538	isocitrate dehydrogenase activity
ZA10_RS03665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZA10_RS03675	COG0203	ribosomal protein L17
ZA10_RS03680	COG0202	RNA polymerase activity
ZA10_RS03685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZA10_RS03690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZA10_RS03695	COG0563	adenylate kinase activity
ZA10_RS03700	COG0201	protein transport
ZA10_RS03705	COG0200	Binds to the 23S rRNA
ZA10_RS03710	COG1841	ribosomal large subunit assembly
ZA10_RS03715	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZA10_RS03720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZA10_RS03725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZA10_RS03730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZA10_RS03735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZA10_RS03740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZA10_RS03745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZA10_RS03750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZA10_RS03755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZA10_RS03760	COG0255	Belongs to the universal ribosomal protein uL29 family
ZA10_RS03765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZA10_RS03770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZA10_RS03775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZA10_RS03780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZA10_RS03785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZA10_RS03790	COG0089	rRNA binding
ZA10_RS03795	COG0088	Forms part of the polypeptide exit tunnel
ZA10_RS03800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZA10_RS03805	COG0051	transcription antitermination factor activity, RNA binding
ZA10_RS03810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZA10_RS03815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZA10_RS03820	COG0049	tRNA binding
ZA10_RS03825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZA10_RS03830	COG0671	phosphoesterase, PA-phosphatase related
ZA10_RS03835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZA10_RS03840	COG1607	acyl-coa hydrolase
ZA10_RS03845	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZA10_RS03860	COG1956	GAF domain-containing protein
ZA10_RS03870	COG0564	pseudouridine synthase activity
ZA10_RS03875	COG0463	Glycosyl transferase, family 2
ZA10_RS03895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZA10_RS03900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZA10_RS03905	COG0546	phosphoglycolate phosphatase activity
ZA10_RS03925	COG0174	glutamine synthetase
ZA10_RS03930	COG0347	Belongs to the P(II) protein family
ZA10_RS03935	COG0006	proline dipeptidase activity
ZA10_RS03965	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ZA10_RS03970	COG1960	acyl-CoA dehydrogenase activity
ZA10_RS03985	COG1494	fructose-1,6-bisphosphatase
ZA10_RS03995	COG5002	protein histidine kinase activity
ZA10_RS04015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZA10_RS04015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZA10_RS04030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZA10_RS04040	COG0583	DNA-binding transcription factor activity
ZA10_RS04055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZA10_RS04065	COG0149	triose-phosphate isomerase activity
ZA10_RS04075	COG0504	CTP synthase activity
ZA10_RS04080	COG0442	prolyl-tRNA aminoacylation
ZA10_RS04090	COG1136	(ABC) transporter
ZA10_RS04095	COG1522	sequence-specific DNA binding
ZA10_RS04105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ZA10_RS04110	COG1160	GTP binding
ZA10_RS04155	COG1372	Participates in initiation and elongation during chromosome replication
ZA10_RS04155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZA10_RS04160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZA10_RS04195	COG0194	GDP metabolic process
ZA10_RS04205	COG2171	N-acyltransferase activity
ZA10_RS04215	COG0316	Belongs to the HesB IscA family
ZA10_RS04220	COG2151	metal-sulfur cluster biosynthetic enzyme
ZA10_RS04225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZA10_RS04230	COG0719	Fe-S assembly protein
ZA10_RS04235	COG0396	ATPase activity
ZA10_RS04240	COG0719	Fe-S assembly protein
ZA10_RS04250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZA10_RS04255	COG0287	Prephenate dehydrogenase
ZA10_RS04275	COG2884	Cell division ATP-binding protein ftsE
ZA10_RS04290	COG2095	MarC family integral membrane protein
ZA10_RS04295	COG0187	DNA topoisomerase II activity
ZA10_RS04305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZA10_RS04310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZA10_RS04320	COG0842	Transport permease protein
ZA10_RS04335	COG0248	Ppx GppA phosphatase
ZA10_RS04340	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ZA10_RS04465	COG1621	beta-fructofuranosidase activity
ZA10_RS04470	COG1621	beta-fructofuranosidase activity
ZA10_RS04480	COG1522	sequence-specific DNA binding
ZA10_RS04485	COG1794	racemase activity, acting on amino acids and derivatives
ZA10_RS04490	COG0837	glucose binding
ZA10_RS04495	COG0129	dihydroxy-acid dehydratase activity
ZA10_RS04500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZA10_RS04505	COG0477	Major facilitator Superfamily
ZA10_RS04510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZA10_RS04515	COG0343	queuine tRNA-ribosyltransferase activity
ZA10_RS04520	COG0556	nucleotide-excision repair
ZA10_RS04530	COG0772	Belongs to the SEDS family
ZA10_RS04555	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZA10_RS04580	COG1678	Uncharacterized ACR, COG1678
ZA10_RS04585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZA10_RS04590	COG1923	regulation of RNA biosynthetic process
ZA10_RS04595	COG0004	ammonium transporteR
ZA10_RS04605	COG0312	modulator of DNA gyrase
ZA10_RS04615	COG0436	Aminotransferase
ZA10_RS04635	COG2894	cell division
ZA10_RS04640	COG0352	thiamine-phosphate diphosphorylase activity
ZA10_RS04645	COG3108	Peptidase M15
ZA10_RS04655	COG0483	inositol monophosphate 1-phosphatase activity
ZA10_RS04660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZA10_RS04665	COG0626	cystathionine gamma-synthase activity
ZA10_RS04670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZA10_RS04680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZA10_RS04685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZA10_RS04690	COG0196	riboflavin kinase activity
ZA10_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS04725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZA10_RS04735	COG1473	amidohydrolase
ZA10_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS04765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZA10_RS04780	COG1570	exodeoxyribonuclease VII activity
ZA10_RS04785	COG0151	Belongs to the GarS family
ZA10_RS04795	COG1253	flavin adenine dinucleotide binding
ZA10_RS04800	COG0590	tRNA wobble adenosine to inosine editing
ZA10_RS04805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZA10_RS04810	COG2814	Major facilitator Superfamily
ZA10_RS04815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZA10_RS04820	COG2733	membrane
ZA10_RS04845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZA10_RS04855	COG1278	Cold shock
ZA10_RS04875	COG1137	ATPase activity
ZA10_RS04880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZA10_RS04885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZA10_RS04890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZA10_RS04935	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZA10_RS04940	COG4133	protoheme IX ABC transporter activity
ZA10_RS04955	COG0277	FAD linked oxidase domain protein
ZA10_RS04960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZA10_RS04990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZA10_RS04995	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZA10_RS05000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZA10_RS05005	COG0776	regulation of translation
ZA10_RS05015	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZA10_RS05020	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZA10_RS05025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZA10_RS05030	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZA10_RS05035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZA10_RS05040	COG0489	protein tyrosine kinase activity
ZA10_RS05045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZA10_RS05060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZA10_RS05070	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZA10_RS05075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZA10_RS05085	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZA10_RS05085	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZA10_RS05090	COG4221	oxidoreductase activity
ZA10_RS05095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZA10_RS05100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZA10_RS05100	COG2813	Specifically methylates the guanine in position
ZA10_RS05115	COG1329	Transcriptional regulator
ZA10_RS05120	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ZA10_RS05125	COG4581	dead DEAH box helicase
ZA10_RS05130	COG0739	heme binding
ZA10_RS05140	COG0534	Mate efflux family protein
ZA10_RS05150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZA10_RS05155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZA10_RS05165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZA10_RS05170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZA10_RS05185	COG0789	Transcriptional regulator
ZA10_RS05190	COG0840	transmembrane signaling receptor activity
ZA10_RS05195	COG0512	Glutamine amidotransferase of anthranilate synthase
ZA10_RS05200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZA10_RS05205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZA10_RS05215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZA10_RS05230	COG1530	ribonuclease E activity
ZA10_RS05250	COG1760	l-serine dehydratase
ZA10_RS05265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ZA10_RS05270	COG0215	cysteine-tRNA ligase activity
ZA10_RS05280	COG0488	(ABC) transporter
ZA10_RS05285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZA10_RS05290	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZA10_RS05295	COG1830	Aldolase
ZA10_RS05310	COG0126	phosphoglycerate kinase activity
ZA10_RS05315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZA10_RS05340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZA10_RS05355	COG0584	glycerophosphoryl diester phosphodiesterase
ZA10_RS05360	COG2885	chlorophyll binding
ZA10_RS05365	COG0823	Involved in the tonB-independent uptake of proteins
ZA10_RS05375	COG0848	biopolymer transport protein
ZA10_RS05380	COG0811	peptide transport
ZA10_RS05385	COG0824	Thioesterase
ZA10_RS05390	COG2255	four-way junction helicase activity
ZA10_RS05395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZA10_RS05405	COG0632	four-way junction helicase activity
ZA10_RS05410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZA10_RS05415	COG0217	transcriptional regulatory protein
ZA10_RS05420	COG3750	Belongs to the UPF0335 family
ZA10_RS05425	COG0469	pyruvate kinase activity
ZA10_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZA10_RS05455	COG1131	(ABC) transporter
ZA10_RS05470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZA10_RS05520	COG0671	phosphoesterase, PA-phosphatase related
ZA10_RS05540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZA10_RS05555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZA10_RS05565	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZA10_RS05570	COG1151	hydroxylamine reductase activity
ZA10_RS05575	COG1959	2 iron, 2 sulfur cluster binding
ZA10_RS05580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZA10_RS05585	COG0512	Glutamine amidotransferase of anthranilate synthase
ZA10_RS05585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZA10_RS05590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZA10_RS05605	COG0488	(ABC) transporter
ZA10_RS05630	COG0066	3-isopropylmalate dehydratase activity
ZA10_RS05635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZA10_RS05640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZA10_RS05670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZA10_RS05680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZA10_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS05715	COG0840	transmembrane signaling receptor activity
ZA10_RS05725	COG0643	Histidine kinase
ZA10_RS05725	COG2198	Histidine kinase
ZA10_RS05730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZA10_RS05735	COG2201	protein-glutamate methylesterase activity
ZA10_RS05740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ZA10_RS05745	COG0745	RESPONSE REGULATOR receiver
ZA10_RS05750	COG0835	chemotaxis
ZA10_RS05755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZA10_RS05760	COG1702	phosphate starvation-inducible protein PhoH
ZA10_RS05765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZA10_RS05780	COG2999	glutathione oxidoreductase activity
ZA10_RS05820	COG1929	Belongs to the glycerate kinase type-1 family
ZA10_RS05835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZA10_RS05840	COG0730	response to heat
ZA10_RS05850	COG0424	maF-like protein
ZA10_RS05860	COG0237	dephospho-CoA kinase activity
ZA10_RS05865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZA10_RS05870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ZA10_RS05875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZA10_RS05890	COG2983	Belongs to the UPF0260 family
ZA10_RS05905	COG1715	Restriction endonuclease
ZA10_RS05910	COG0138	bifunctional purine biosynthesis protein purh
ZA10_RS05930	COG0247	lactate metabolic process
ZA10_RS05935	COG1139	Iron-sulfur cluster binding protein
ZA10_RS05965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZA10_RS05975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZA10_RS05980	COG1420	regulation of RNA biosynthetic process
ZA10_RS05985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZA10_RS05990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZA10_RS05995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZA10_RS06010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZA10_RS06015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZA10_RS06020	COG0175	sulfate reduction
ZA10_RS06025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZA10_RS06025	COG1648	precorrin-2 dehydrogenase activity
ZA10_RS06030	COG0175	sulfate reduction
ZA10_RS06045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZA10_RS06055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZA10_RS06065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ZA10_RS06080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZA10_RS06085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZA10_RS06090	COG4771	TonB-dependent receptor
ZA10_RS06095	COG0667	Aldo Keto reductase
ZA10_RS06100	COG3386	PFAM SMP-30 Gluconolaconase
ZA10_RS06105	COG0445	tRNA wobble uridine modification
ZA10_RS06110	COG0357	Ribosomal RNA small subunit methyltransferase G
ZA10_RS06125	COG0477	Major facilitator Superfamily
ZA10_RS06140	COG0583	DNA-binding transcription factor activity
ZA10_RS06150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ZA10_RS06155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ZA10_RS06180	COG2333	competence protein COMEC
ZA10_RS06180	COG0658	competence protein
ZA10_RS06185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZA10_RS06190	COG0372	Belongs to the citrate synthase family
ZA10_RS06195	COG5002	protein histidine kinase activity
ZA10_RS06220	COG0438	transferase activity, transferring glycosyl groups
ZA10_RS06220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZA10_RS06225	COG0497	DNA recombination
ZA10_RS06235	COG0459	protein refolding
ZA10_RS06240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZA10_RS06245	COG0616	signal peptide processing
ZA10_RS06250	COG0826	peptidase U32
ZA10_RS06260	COG1368	sulfuric ester hydrolase activity
ZA10_RS06285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZA10_RS06290	COG0156	8-amino-7-oxononanoate synthase activity
ZA10_RS06300	COG4106	trans-aconitate 2-methyltransferase activity
ZA10_RS06300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZA10_RS06310	COG0189	ligase activity
ZA10_RS06315	COG0012	GTP binding
ZA10_RS06320	COG0193	aminoacyl-tRNA hydrolase activity
ZA10_RS06325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZA10_RS06340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZA10_RS06345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZA10_RS06350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZA10_RS06355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZA10_RS06360	COG0181	hydroxymethylbilane synthase activity
ZA10_RS06375	COG0416	fatty acid biosynthetic process
ZA10_RS06380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZA10_RS06390	COG1862	Preprotein translocase
ZA10_RS06395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZA10_RS06405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZA10_RS06425	COG0612	Peptidase, M16
ZA10_RS06440	COG1335	isochorismatase
ZA10_RS06445	COG3180	Ammonia monooxygenase
ZA10_RS06450	COG1902	pentaerythritol trinitrate reductase activity
ZA10_RS06455	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZA10_RS06460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZA10_RS06465	COG3180	Ammonia monooxygenase
ZA10_RS06480	COG0113	porphobilinogen synthase activity
ZA10_RS06485	COG0525	valine-tRNA ligase activity
ZA10_RS06510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ZA10_RS06520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ZA10_RS06540	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZA10_RS06635	COG0681	Belongs to the peptidase S26 family
ZA10_RS06680	COG0464	growth
ZA10_RS06685	COG1404	Belongs to the peptidase S8 family
ZA10_RS06695	COG4221	oxidoreductase activity
ZA10_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS06720	COG2070	2-Nitropropane dioxygenase
ZA10_RS06790	COG2176	DNA-directed DNA polymerase activity
ZA10_RS06815	COG4227	nucleotidyltransferase activity
ZA10_RS06865	COG5433	transposase activity
ZA10_RS06885	COG5433	transposase activity
ZA10_RS06905	COG3550	peptidyl-serine autophosphorylation
ZA10_RS06910	COG3620	sequence-specific DNA binding
ZA10_RS06945	COG1192	Involved in chromosome partitioning
ZA10_RS06970	COG0741	lytic transglycosylase activity
ZA10_RS07010	COG4962	Type ii secretion system protein e
ZA10_RS07025	COG3451	type IV secretory pathway VirB4
ZA10_RS07040	COG3846	protein secretion by the type IV secretion system
ZA10_RS07055	COG2948	multi-organism process
ZA10_RS07070	COG0583	DNA-binding transcription factor activity
ZA10_RS07075	COG0419	ATPase involved in DNA repair
ZA10_RS07080	COG0420	3'-5' exonuclease activity
ZA10_RS07125	COG0583	DNA-binding transcription factor activity
ZA10_RS07145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZA10_RS07150	COG0716	FMN binding
ZA10_RS07170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZA10_RS07175	COG1120	ATPase activity
ZA10_RS07180	COG2824	Alkylphosphonate utilization operon protein PhnA
ZA10_RS07185	COG0673	inositol 2-dehydrogenase activity
ZA10_RS07205	COG3585	molybdate ion transport
ZA10_RS07220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZA10_RS07225	COG1104	cysteine desulfurase activity
ZA10_RS07255	COG1433	Dinitrogenase iron-molybdenum cofactor
ZA10_RS07260	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZA10_RS07265	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZA10_RS07270	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZA10_RS07275	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZA10_RS07280	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ZA10_RS07300	COG5554	nitrogen fixation
ZA10_RS07310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZA10_RS07315	COG0535	radical SAM domain protein
ZA10_RS07320	COG3604	Transcriptional regulator
ZA10_RS07330	COG4657	Part of a membrane complex involved in electron transport
ZA10_RS07340	COG4656	Part of a membrane complex involved in electron transport
ZA10_RS07345	COG4658	electron transport chain
ZA10_RS07370	COG0110	maltose O-acetyltransferase activity
ZA10_RS07375	COG0546	phosphoglycolate phosphatase activity
ZA10_RS07380	COG0531	amino acid
ZA10_RS07385	COG0776	regulation of translation
ZA10_RS07395	COG0539	negative regulation of cytoplasmic translation
ZA10_RS07400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZA10_RS07405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZA10_RS07420	COG0583	DNA-binding transcription factor activity
ZA10_RS07425	COG0129	dihydroxy-acid dehydratase activity
ZA10_RS07435	COG1132	(ABC) transporter
ZA10_RS07455	COG0668	transmembrane transport
ZA10_RS07495	COG0656	L-ascorbic acid biosynthetic process
ZA10_RS07500	COG0604	alcohol dehydrogenase
ZA10_RS07500	COG3321	synthase
ZA10_RS07505	COG1979	alcohol dehydrogenase
ZA10_RS07510	COG0165	Argininosuccinate lyase
ZA10_RS07520	COG0019	diaminopimelate decarboxylase activity
ZA10_RS07535	COG2989	Protein conserved in bacteria
ZA10_RS07545	COG0792	nuclease activity
ZA10_RS07550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZA10_RS07560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZA10_RS07565	COG3265	gluconokinase activity
ZA10_RS07570	COG2610	gluconate transmembrane transporter activity
ZA10_RS07575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZA10_RS07580	COG1012	belongs to the aldehyde dehydrogenase family
ZA10_RS07605	COG2853	Lipoprotein
ZA10_RS07625	COG0646	methionine synthase
ZA10_RS07625	COG1410	methionine synthase
ZA10_RS07635	COG0481	GTPase activity
ZA10_RS07645	COG3275	phosphorelay sensor kinase activity
ZA10_RS07650	COG3279	Response regulator of the LytR AlgR family
ZA10_RS07665	COG0583	DNA-binding transcription factor activity
ZA10_RS07675	COG1045	serine acetyltransferase
ZA10_RS07690	COG0436	Aminotransferase
ZA10_RS07695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ZA10_RS07700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZA10_RS07715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ZA10_RS07725	COG1758	RNA polymerase activity
ZA10_RS07730	COG1940	carbohydrate kinase activity
ZA10_RS07760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZA10_RS07770	COG0628	permease
ZA10_RS07775	COG0681	Belongs to the peptidase S26 family
ZA10_RS07780	COG0736	holo-[acyl-carrier-protein] synthase activity
ZA10_RS07785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZA10_RS07790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZA10_RS07805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZA10_RS07810	COG1674	ftsk spoiiie
ZA10_RS07815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ZA10_RS07825	COG0708	Exodeoxyribonuclease III
ZA10_RS07835	COG1733	regulation of RNA biosynthetic process
ZA10_RS07855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZA10_RS07860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZA10_RS07865	COG1295	ribonuclease BN
ZA10_RS07870	COG0484	heat shock protein binding
ZA10_RS07875	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZA10_RS07880	COG0354	folic acid binding
ZA10_RS07885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZA10_RS07895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZA10_RS07905	COG0252	asparaginase activity
ZA10_RS07915	COG2985	domain, Protein
ZA10_RS07930	COG0077	Prephenate dehydratase
ZA10_RS07935	COG1194	a g-specific adenine glycosylase
ZA10_RS07950	COG0656	L-ascorbic acid biosynthetic process
ZA10_RS07970	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ZA10_RS07980	COG0793	Belongs to the peptidase S41A family
ZA10_RS07990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZA10_RS07995	COG0799	negative regulation of ribosome biogenesis
ZA10_RS08000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZA10_RS08005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZA10_RS08020	COG0037	tRNA processing
ZA10_RS08040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ZA10_RS08055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ZA10_RS08065	COG3386	PFAM SMP-30 Gluconolaconase
ZA10_RS08070	COG1573	uracil-dna glycosylase
ZA10_RS08085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZA10_RS08095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZA10_RS08100	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ZA10_RS08110	COG0180	Tryptophanyl-tRNA synthetase
ZA10_RS08120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ZA10_RS08135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ZA10_RS08150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZA10_RS08175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZA10_RS08180	COG0706	membrane insertase activity
ZA10_RS08185	COG0594	ribonuclease P activity
ZA10_RS08195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZA10_RS08215	COG0505	Belongs to the CarA family
ZA10_RS08225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZA10_RS08255	COG0148	phosphopyruvate hydratase activity
ZA10_RS08265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZA10_RS08270	COG0022	dehydrogenase e1 component
ZA10_RS08270	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZA10_RS08280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZA10_RS08280	COG3453	Protein conserved in bacteria
ZA10_RS08290	COG0328	RNA-DNA hybrid ribonuclease activity
ZA10_RS08295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZA10_RS08305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZA10_RS08310	COG1454	alcohol dehydrogenase
ZA10_RS08325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZA10_RS08330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZA10_RS08335	COG1127	ABC transporter
ZA10_RS08345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZA10_RS08360	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZA10_RS08420	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS08430	COG4221	oxidoreductase activity
ZA10_RS08450	COG1294	oxidase, subunit
ZA10_RS08455	COG1271	oxidase subunit
ZA10_RS08470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZA10_RS08485	COG1742	UPF0060 membrane protein
ZA10_RS08505	COG1051	belongs to the nudix hydrolase family
ZA10_RS08510	COG4221	oxidoreductase activity
ZA10_RS08520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZA10_RS08535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZA10_RS08540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZA10_RS08545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZA10_RS08550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZA10_RS08560	COG1657	PFAM Prenyltransferase squalene oxidase
ZA10_RS08585	COG0629	single-stranded DNA binding
ZA10_RS08630	COG0047	phosphoribosylformylglycinamidine synthase activity
ZA10_RS08635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZA10_RS08640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZA10_RS08640	COG0517	IMP dehydrogenase activity
ZA10_RS08645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZA10_RS08660	COG1538	Outer membrane efflux protein
ZA10_RS08685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZA10_RS08695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZA10_RS08700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZA10_RS08705	COG0072	phenylalanine-tRNA ligase activity
ZA10_RS08705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZA10_RS08710	COG5265	(ABC) transporter
ZA10_RS08720	COG2890	protein-(glutamine-N5) methyltransferase activity
ZA10_RS08725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZA10_RS08730	COG0124	histidyl-tRNA synthetase
ZA10_RS08735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZA10_RS08755	COG0131	Imidazoleglycerol-phosphate dehydratase
ZA10_RS08760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZA10_RS08765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZA10_RS08770	COG0107	imidazoleglycerol-phosphate synthase activity
ZA10_RS08775	COG0140	phosphoribosyl-ATP diphosphatase activity
ZA10_RS08785	COG0531	amino acid
ZA10_RS08790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZA10_RS08795	COG2096	Adenosyltransferase
ZA10_RS08800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZA10_RS08820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZA10_RS08825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZA10_RS08830	COG2200	EAL domain
ZA10_RS08830	COG2199	diguanylate cyclase activity
ZA10_RS08850	COG0210	DNA helicase
ZA10_RS08865	COG0045	succinate-CoA ligase (ADP-forming) activity
ZA10_RS08880	COG0363	glucosamine-6-phosphate deaminase activity
ZA10_RS08900	COG1217	gtp-binding protein TYPA
ZA10_RS08915	COG0814	amino acid
ZA10_RS08965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ZA10_RS08970	COG2814	Major facilitator Superfamily
ZA10_RS08980	COG0415	Belongs to the DNA photolyase family
ZA10_RS08985	COG0246	Mannitol dehydrogenase
ZA10_RS09005	COG0752	glycyl-tRNA synthetase alpha subunit
ZA10_RS09015	COG2244	polysaccharide biosynthetic process
ZA10_RS09035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZA10_RS09055	COG0495	leucyl-tRNA aminoacylation
ZA10_RS09090	COG1597	lipid kinase activity
ZA10_RS09095	COG2003	Belongs to the UPF0758 family
ZA10_RS09100	COG0352	thiamine-phosphate diphosphorylase activity
ZA10_RS09110	COG0612	Peptidase, M16
ZA10_RS09115	COG0612	Peptidase, M16
ZA10_RS09120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZA10_RS09125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZA10_RS09130	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ZA10_RS09135	COG0513	Belongs to the DEAD box helicase family
ZA10_RS09145	COG1214	PFAM Peptidase M22, glycoprotease
ZA10_RS09155	COG4957	zinc ion binding
ZA10_RS09165	COG2193	ferroxidase activity
ZA10_RS09185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZA10_RS09190	COG0596	Alpha beta hydrolase
ZA10_RS09195	COG0784	Response regulator, receiver
ZA10_RS09205	COG0739	heme binding
ZA10_RS09210	COG0316	Belongs to the HesB IscA family
ZA10_RS09215	COG0708	Exodeoxyribonuclease III
ZA10_RS09275	COG0405	Gamma-glutamyltransferase
ZA10_RS09295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZA10_RS09300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZA10_RS09330	COG0571	ribonuclease III activity
ZA10_RS09340	COG0300	oxidoreductase activity
ZA10_RS09360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZA10_RS09370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZA10_RS09390	COG3961	Belongs to the TPP enzyme family
ZA10_RS09395	COG0268	Binds directly to 16S ribosomal RNA
ZA10_RS09440	COG3077	Addiction module antitoxin, RelB DinJ family
ZA10_RS09450	COG3654	unkown
ZA10_RS09470	COG1192	Involved in chromosome partitioning
ZA10_RS09485	COG3293	Transposase
ZA10_RS09505	COG1002	Type II restriction enzyme, methylase subunits
ZA10_RS09510	COG1061	Type III restriction enzyme res subunit
ZA10_RS09535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ZA10_RS09545	COG3041	Addiction module toxin RelE StbE family
ZA10_RS09550	COG1192	Involved in chromosome partitioning
ZA10_RS09560	COG3311	Transcriptional regulator
ZA10_RS09625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ZA10_RS09650	COG1215	transferase activity, transferring glycosyl groups
ZA10_RS09655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ZA10_RS09670	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ZA10_RS09695	COG1132	(ABC) transporter
ZA10_RS09700	COG1132	(ABC) transporter
ZA10_RS09700	COG2375	cellular response to nickel ion
ZA10_RS09725	COG1028	Short-chain dehydrogenase reductase Sdr
ZA10_RS09735	COG3041	Addiction module toxin RelE StbE family
ZA10_RS09780	COG3293	Transposase
ZA10_RS09785	COG3077	Addiction module antitoxin, RelB DinJ family
ZA10_RS09790	COG2026	Addiction module toxin, RelE StbE family
ZA10_RS09820	COG1518	maintenance of DNA repeat elements
ZA10_RS09825	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ZA10_RS09830	COG3293	Transposase
ZA10_RS09855	COG3041	Addiction module toxin RelE StbE family
ZA10_RS09860	COG3077	Addiction module antitoxin, RelB DinJ family
ZA10_RS09890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import