locus-tag	class	description
A254_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A254_RS00010	COG0488	(ABC) transporter
A254_RS00015	COG2885	chlorophyll binding
A254_RS00015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A254_RS00020	COG4702	Belongs to the UPF0303 family
A254_RS00025	COG0670	Belongs to the BI1 family
A254_RS00035	COG1058	Belongs to the CinA family
A254_RS00035	COG1546	Belongs to the CinA family
A254_RS00040	COG0024	Methionine aminopeptidase
A254_RS00055	COG0308	aminopeptidase N
A254_RS00080	COG2321	neutral zinc metallopeptidase
A254_RS00090	COG1280	lysine exporter protein (LysE YggA)
A254_RS00095	COG1741	Belongs to the pirin family
A254_RS00100	COG0583	DNA-binding transcription factor activity
A254_RS00105	COG0655	NAD(P)H dehydrogenase (quinone) activity
A254_RS00110	COG2353	YceI-like domain
A254_RS00115	COG0668	transmembrane transport
A254_RS00120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A254_RS00125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A254_RS00140	COG1660	Displays ATPase and GTPase activities
A254_RS00145	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A254_RS00150	COG0642	Histidine kinase
A254_RS00155	COG0745	RESPONSE REGULATOR receiver
A254_RS00165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A254_RS00175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A254_RS00180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A254_RS00185	COG2244	polysaccharide biosynthetic process
A254_RS00195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A254_RS00200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A254_RS00205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A254_RS00210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A254_RS00215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A254_RS00225	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A254_RS00225	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A254_RS00230	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A254_RS00245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A254_RS00250	COG0321	lipoyl(octanoyl) transferase activity
A254_RS00270	COG0602	queuosine metabolic process
A254_RS00275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A254_RS00285	COG2261	transglycosylase associated protein
A254_RS00290	COG2223	nitrite transmembrane transporter activity
A254_RS00315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A254_RS00320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A254_RS00325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A254_RS00340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A254_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
A254_RS00360	COG0156	8-amino-7-oxononanoate synthase activity
A254_RS00375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A254_RS00375	COG0519	Catalyzes the synthesis of GMP from XMP
A254_RS00385	COG4948	Mandelate Racemase Muconate Lactonizing
A254_RS00390	COG1116	anion transmembrane transporter activity
A254_RS00395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A254_RS00400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A254_RS00405	COG4771	TonB-dependent receptor
A254_RS00410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A254_RS00415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A254_RS00420	COG1138	Cytochrome C-type biogenesis protein
A254_RS00425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A254_RS00430	COG3088	subunit of a heme lyase
A254_RS00460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A254_RS00470	COG2866	Carboxypeptidase
A254_RS00475	COG0588	phosphoglycerate mutase activity
A254_RS00480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A254_RS00485	COG1064	alcohol dehydrogenase
A254_RS00495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A254_RS00540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A254_RS00540	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A254_RS00545	COG0302	gtp cyclohydrolase
A254_RS00550	COG4948	Mandelate Racemase Muconate Lactonizing
A254_RS00555	COG0359	binds to the 23S rRNA
A254_RS00560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A254_RS00565	COG0360	Binds together with S18 to 16S ribosomal RNA
A254_RS00575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A254_RS00590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A254_RS00595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A254_RS00600	COG0805	protein transport
A254_RS00620	COG0513	Belongs to the DEAD box helicase family
A254_RS00630	COG0166	Belongs to the GPI family
A254_RS00645	COG3158	transport of potassium into the cell
A254_RS00660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A254_RS00680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A254_RS00685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A254_RS00695	COG0156	8-amino-7-oxononanoate synthase activity
A254_RS00700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A254_RS00705	COG2814	Major facilitator Superfamily
A254_RS00710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A254_RS00715	COG0758	DNA mediated transformation
A254_RS00720	COG1754	DNA topoisomerase type I activity
A254_RS00720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A254_RS00725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A254_RS00730	COG0756	dUTP diphosphatase activity
A254_RS00735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A254_RS00740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A254_RS00745	COG2226	methyltransferase
A254_RS00755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A254_RS00780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A254_RS00795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A254_RS00800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A254_RS00810	COG2205	protein histidine kinase activity
A254_RS00825	COG3724	N-succinylarginine dihydrolase activity
A254_RS00830	COG1472	Belongs to the glycosyl hydrolase 3 family
A254_RS00840	COG2971	BadF BadG BcrA BcrD
A254_RS00850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A254_RS00855	COG1040	competence protein
A254_RS00860	COG0745	RESPONSE REGULATOR receiver
A254_RS00865	COG0704	Plays a role in the regulation of phosphate uptake
A254_RS00875	COG0688	phosphatidylethanolamine metabolic process
A254_RS00880	COG1183	phosphatidylcholine synthase activity
A254_RS00885	COG1794	racemase activity, acting on amino acids and derivatives
A254_RS00895	COG0052	Belongs to the universal ribosomal protein uS2 family
A254_RS00900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A254_RS00905	COG0528	UMP kinase activity
A254_RS00910	COG0233	cytoplasmic translational termination
A254_RS00915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A254_RS00920	COG0575	Belongs to the CDS family
A254_RS00925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A254_RS00930	COG0750	zinc metalloprotease
A254_RS00935	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A254_RS00945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A254_RS00950	COG0254	rRNA binding
A254_RS00965	COG0492	ferredoxin-NADP+ reductase activity
A254_RS00970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A254_RS00975	COG0440	acetolactate synthase activity
A254_RS00980	COG0028	Belongs to the TPP enzyme family
A254_RS00985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A254_RS00995	COG1858	cytochrome C peroxidase
A254_RS01000	COG0312	modulator of DNA gyrase
A254_RS01010	COG0288	reversible hydration of carbon dioxide
A254_RS01015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A254_RS01020	COG2867	negative regulation of translational initiation
A254_RS01025	COG1058	Belongs to the CinA family
A254_RS01025	COG1546	Belongs to the CinA family
A254_RS01035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A254_RS01035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A254_RS01045	COG2204	response regulator
A254_RS01050	COG5000	phosphorelay sensor kinase activity
A254_RS01055	COG2204	response regulator
A254_RS01065	COG0776	regulation of translation
A254_RS01090	COG1968	undecaprenyl-diphosphatase activity
A254_RS01100	COG1573	uracil-dna glycosylase
A254_RS01105	COG1252	NADH dehydrogenase
A254_RS01110	COG2917	probably involved in intracellular septation
A254_RS01115	COG2807	transmembrane transport
A254_RS01125	COG1522	sequence-specific DNA binding
A254_RS01140	COG2205	protein histidine kinase activity
A254_RS01145	COG0802	atpase or kinase
A254_RS01150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A254_RS01160	COG1074	ATP-dependent DNA helicase activity
A254_RS01170	COG0557	exoribonuclease II activity
A254_RS01175	COG3956	TIGRFAM MazG family protein
A254_RS01185	COG0084	hydrolase, TatD family'
A254_RS01195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A254_RS01200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A254_RS01205	COG1686	Belongs to the peptidase S11 family
A254_RS01215	COG2951	lytic endotransglycosylase activity
A254_RS01220	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A254_RS01225	COG0457	Tetratricopeptide repeat
A254_RS01235	COG1215	transferase activity, transferring glycosyl groups
A254_RS01250	COG0335	large ribosomal subunit rRNA binding
A254_RS01255	COG0336	Belongs to the RNA methyltransferase TrmD family
A254_RS01260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A254_RS01265	COG0228	four-way junction DNA binding
A254_RS01270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A254_RS01275	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A254_RS01280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A254_RS01285	COG0552	protein localization to endoplasmic reticulum
A254_RS01290	COG0484	heat shock protein binding
A254_RS01320	COG1842	Phage shock protein A
A254_RS01330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A254_RS01350	COG0617	tRNA 3'-terminal CCA addition
A254_RS01355	COG5001	Diguanylate cyclase
A254_RS01360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A254_RS01365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A254_RS01370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A254_RS01375	COG0581	inorganic phosphate transmembrane transporter activity
A254_RS01380	COG0573	inorganic phosphate transmembrane transporter activity
A254_RS01385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A254_RS01395	COG1970	mechanosensitive ion channel activity
A254_RS01405	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A254_RS01425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A254_RS01435	COG0137	argininosuccinate synthase activity
A254_RS01445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A254_RS01450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A254_RS01480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A254_RS01485	COG1104	cysteine desulfurase activity
A254_RS01490	COG2945	thiolester hydrolase activity
A254_RS01495	COG0019	diaminopimelate decarboxylase activity
A254_RS01505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A254_RS01510	COG1127	ABC transporter
A254_RS01525	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A254_RS01530	COG0424	maF-like protein
A254_RS01540	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A254_RS01560	COG0277	FAD linked oxidase domain protein
A254_RS01565	COG3781	membrane
A254_RS01570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A254_RS01580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A254_RS01585	COG0351	phosphomethylpyrimidine kinase
A254_RS01585	COG0352	thiamine-phosphate diphosphorylase activity
A254_RS01590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A254_RS01595	COG3104	oligopeptide transport
A254_RS01600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A254_RS01605	COG0009	L-threonylcarbamoyladenylate synthase
A254_RS01610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A254_RS01615	COG0800	Aldolase
A254_RS01620	COG0668	transmembrane transport
A254_RS01635	COG0071	Belongs to the small heat shock protein (HSP20) family
A254_RS01650	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A254_RS01655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A254_RS01670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A254_RS01675	COG4172	Belongs to the ABC transporter superfamily
A254_RS01685	COG4206	TonB-dependent receptor
A254_RS01695	COG0667	Aldo Keto reductase
A254_RS01725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A254_RS01735	COG2252	PERMEase
A254_RS01745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A254_RS01750	COG2814	Major facilitator Superfamily
A254_RS01755	COG1566	PFAM secretion protein HlyD family protein
A254_RS01765	COG1309	transcriptional regulator
A254_RS01770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A254_RS01785	COG2857	Cytochrome c1
A254_RS01790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A254_RS01795	COG0723	plastoquinol--plastocyanin reductase activity
A254_RS01810	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A254_RS01815	COG0408	coproporphyrinogen oxidase activity
A254_RS01825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A254_RS01830	COG0740	serine-type endopeptidase activity
A254_RS01840	COG0544	peptidyl-prolyl cis-trans isomerase activity
A254_RS01860	COG1621	beta-fructofuranosidase activity
A254_RS01875	COG1846	Transcriptional regulator
A254_RS01880	COG0402	S-adenosylhomocysteine deaminase activity
A254_RS01885	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
A254_RS01890	COG1448	Aminotransferase
A254_RS01895	COG0697	spore germination
A254_RS01925	COG3191	aminopeptidase activity
A254_RS01930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A254_RS01940	COG1278	Cold shock
A254_RS01945	COG0653	protein targeting
A254_RS01950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A254_RS01990	COG2217	Heavy metal translocating P-type atpase
A254_RS01995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A254_RS02000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A254_RS02040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A254_RS02050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A254_RS02065	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A254_RS02065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A254_RS02100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A254_RS02100	COG1199	ATP-dependent helicase activity
A254_RS02105	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A254_RS02130	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A254_RS02135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A254_RS02140	COG0840	transmembrane signaling receptor activity
A254_RS02145	COG0643	Histidine kinase
A254_RS02145	COG2198	Histidine kinase
A254_RS02150	COG2201	protein-glutamate methylesterase activity
A254_RS02165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A254_RS02180	COG1657	PFAM Prenyltransferase squalene oxidase
A254_RS02185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A254_RS02190	COG1562	ergosterol biosynthetic process
A254_RS02195	COG1562	ergosterol biosynthetic process
A254_RS02200	COG1215	transferase activity, transferring glycosyl groups
A254_RS02205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A254_RS02215	COG0305	Participates in initiation and elongation during chromosome replication
A254_RS02220	COG0295	cytidine deaminase activity
A254_RS02225	COG0717	Belongs to the dCTP deaminase family
A254_RS02230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A254_RS02235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A254_RS02245	COG1104	cysteine desulfurase activity
A254_RS02255	COG1722	exodeoxyribonuclease VII activity
A254_RS02260	COG0142	geranyltranstransferase activity
A254_RS02265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A254_RS02275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A254_RS02280	COG0259	pyridoxamine-phosphate oxidase activity
A254_RS02305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A254_RS02315	COG0018	arginyl-trna synthetase
A254_RS02320	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A254_RS02325	COG0038	chloride channel
A254_RS02335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A254_RS02340	COG0849	cell division
A254_RS02345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A254_RS02350	COG1181	Belongs to the D-alanine--D-alanine ligase family
A254_RS02355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A254_RS02360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A254_RS02365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A254_RS02375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A254_RS02380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A254_RS02390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A254_RS02405	COG0275	rRNA processing
A254_RS02425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A254_RS02430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A254_RS02435	COG0720	synthase
A254_RS02450	COG1322	Protein conserved in bacteria
A254_RS02455	COG0242	peptide deformylase activity
A254_RS02460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A254_RS02465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A254_RS02470	COG0101	tRNA pseudouridine synthase activity
A254_RS02475	COG1872	DUF167
A254_RS02480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A254_RS02485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A254_RS02515	COG1129	ABC transporter
A254_RS02515	COG0842	Transport permease protein
A254_RS02520	COG0842	Transport permease protein
A254_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
A254_RS02540	COG1505	serine-type exopeptidase activity
A254_RS02550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A254_RS02555	COG0540	Belongs to the ATCase OTCase family
A254_RS02585	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A254_RS02590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A254_RS02595	COG0154	amidase activity
A254_RS02600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A254_RS02605	COG0583	DNA-binding transcription factor activity
A254_RS02610	COG1538	Outer membrane efflux protein
A254_RS02625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A254_RS02645	COG2239	Acts as a magnesium transporter
A254_RS02650	COG0482	sulfurtransferase activity
A254_RS02665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A254_RS02670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A254_RS02690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A254_RS02715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A254_RS02730	COG0564	pseudouridine synthase activity
A254_RS02735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A254_RS02770	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A254_RS02780	COG2329	Antibiotic biosynthesis monooxygenase
A254_RS02785	COG2022	thiamine diphosphate biosynthetic process
A254_RS02790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A254_RS02795	COG0511	ligase activity, forming carbon-carbon bonds
A254_RS02800	COG0439	Biotin carboxylase
A254_RS02815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A254_RS02820	COG0085	RNA polymerase activity
A254_RS02830	COG0222	ribosome binding
A254_RS02835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A254_RS02840	COG0081	regulation of translation
A254_RS02845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A254_RS02855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A254_RS02865	COG3590	peptidase
A254_RS02870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A254_RS02875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A254_RS02880	COG0741	lytic transglycosylase activity
A254_RS02890	COG2326	polyphosphate kinase activity
A254_RS02895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A254_RS02900	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A254_RS02905	COG0248	Ppx GppA phosphatase
A254_RS02910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A254_RS02925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A254_RS02930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A254_RS02935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A254_RS02950	COG0318	PFAM AMP-dependent synthetase and ligase
A254_RS02970	COG2076	Multidrug Resistance protein
A254_RS03000	COG1764	response to oxidative stress
A254_RS03005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A254_RS03010	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A254_RS03015	COG0673	inositol 2-dehydrogenase activity
A254_RS03020	COG0679	Auxin Efflux Carrier
A254_RS03070	COG0473	3-isopropylmalate dehydrogenase activity
A254_RS03080	COG0583	DNA-binding transcription factor activity
A254_RS03090	COG1381	Involved in DNA repair and RecF pathway recombination
A254_RS03095	COG0322	excinuclease ABC activity
A254_RS03100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A254_RS03105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A254_RS03115	COG0356	it plays a direct role in the translocation of protons across the membrane
A254_RS03140	COG2003	Belongs to the UPF0758 family
A254_RS03145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A254_RS03150	COG0484	heat shock protein binding
A254_RS03155	COG0443	Heat shock 70 kDa protein
A254_RS03170	COG3138	arginine N-succinyltransferase
A254_RS03185	COG0726	polysaccharide deacetylase
A254_RS03190	COG0628	permease
A254_RS03205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A254_RS03210	COG1684	flagellar biosynthetic protein fliR
A254_RS03215	COG1987	bacterial-type flagellum assembly
A254_RS03235	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A254_RS03265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A254_RS03275	COG1677	Flagellar hook-basal body complex protein FliE
A254_RS03285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A254_RS03305	COG0455	bacterial-type flagellum organization
A254_RS03335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A254_RS03350	COG1558	bacterial-type flagellum-dependent cell motility
A254_RS03355	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A254_RS03360	COG1749	Flagellar hook protein flgE
A254_RS03375	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A254_RS03380	COG1706	bacterial-type flagellum-dependent cell motility
A254_RS03420	COG0825	malonyl-CoA metabolic process
A254_RS03425	COG4974	Belongs to the 'phage' integrase family
A254_RS03435	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A254_RS03440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A254_RS03455	COG1286	toxin biosynthetic process
A254_RS03470	COG0284	orotidine-5'-phosphate decarboxylase activity
A254_RS03475	COG0135	phosphoribosylanthranilate isomerase activity
A254_RS03480	COG0133	tryptophan synthase activity
A254_RS03485	COG0159	tryptophan synthase activity
A254_RS03490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A254_RS03495	COG0285	dihydrofolate synthase activity
A254_RS03500	COG2223	nitrite transmembrane transporter activity
A254_RS03505	COG1301	dicarboxylic acid transport
A254_RS03510	COG1187	pseudouridine synthase activity
A254_RS03515	COG0742	ribosomal rna small subunit methyltransferase
A254_RS03525	COG2999	glutathione oxidoreductase activity
A254_RS03530	COG1116	anion transmembrane transporter activity
A254_RS03535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A254_RS03545	COG2264	protein methyltransferase activity
A254_RS03565	COG2814	Major facilitator Superfamily
A254_RS03570	COG1643	Atp-dependent helicase
A254_RS03575	COG0142	geranyltranstransferase activity
A254_RS03580	COG1605	Chorismate mutase
A254_RS03580	COG0287	Prephenate dehydrogenase
A254_RS03585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A254_RS03595	COG2133	pyrroloquinoline quinone binding
A254_RS03600	COG0779	Required for maturation of 30S ribosomal subunits
A254_RS03615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A254_RS03615	COG3064	Membrane
A254_RS03620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A254_RS03625	COG1435	thymidine kinase activity
A254_RS03630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A254_RS03635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A254_RS03640	COG1185	polyribonucleotide nucleotidyltransferase activity
A254_RS03650	COG0038	chloride channel
A254_RS03655	COG0659	secondary active sulfate transmembrane transporter activity
A254_RS03665	COG0134	indole-3-glycerol-phosphate synthase activity
A254_RS03670	COG0538	isocitrate dehydrogenase activity
A254_RS03675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A254_RS03685	COG0203	ribosomal protein L17
A254_RS03690	COG0202	RNA polymerase activity
A254_RS03695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A254_RS03700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A254_RS03705	COG0563	adenylate kinase activity
A254_RS03710	COG0201	protein transport
A254_RS03715	COG0200	Binds to the 23S rRNA
A254_RS03720	COG1841	ribosomal large subunit assembly
A254_RS03725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A254_RS03730	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A254_RS03735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A254_RS03740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A254_RS03745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A254_RS03750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A254_RS03755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A254_RS03760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A254_RS03765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A254_RS03770	COG0255	Belongs to the universal ribosomal protein uL29 family
A254_RS03775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A254_RS03780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A254_RS03785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A254_RS03790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A254_RS03795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A254_RS03800	COG0089	rRNA binding
A254_RS03805	COG0088	Forms part of the polypeptide exit tunnel
A254_RS03810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A254_RS03815	COG0051	transcription antitermination factor activity, RNA binding
A254_RS03820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A254_RS03825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A254_RS03830	COG0049	tRNA binding
A254_RS03835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A254_RS03840	COG0671	phosphoesterase, PA-phosphatase related
A254_RS03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A254_RS03850	COG1607	acyl-coa hydrolase
A254_RS03855	COG0508	dehydrogenase complex catalyzes the overall conversion of
A254_RS03870	COG1956	GAF domain-containing protein
A254_RS03880	COG0564	pseudouridine synthase activity
A254_RS03885	COG0463	Glycosyl transferase, family 2
A254_RS03905	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A254_RS03910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A254_RS03915	COG0546	phosphoglycolate phosphatase activity
A254_RS03935	COG0174	glutamine synthetase
A254_RS03940	COG0347	Belongs to the P(II) protein family
A254_RS03945	COG0006	proline dipeptidase activity
A254_RS03975	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A254_RS03980	COG1960	acyl-CoA dehydrogenase activity
A254_RS03995	COG1494	fructose-1,6-bisphosphatase
A254_RS04005	COG5002	protein histidine kinase activity
A254_RS04025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A254_RS04025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A254_RS04040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A254_RS04050	COG0583	DNA-binding transcription factor activity
A254_RS04065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A254_RS04075	COG0149	triose-phosphate isomerase activity
A254_RS04085	COG0504	CTP synthase activity
A254_RS04090	COG0442	prolyl-tRNA aminoacylation
A254_RS04100	COG1136	(ABC) transporter
A254_RS04105	COG1522	sequence-specific DNA binding
A254_RS04115	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A254_RS04120	COG1160	GTP binding
A254_RS04150	COG1696	Membrane protein involved in D-alanine export
A254_RS04165	COG1372	Participates in initiation and elongation during chromosome replication
A254_RS04165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A254_RS04170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A254_RS04205	COG0194	GDP metabolic process
A254_RS04215	COG2171	N-acyltransferase activity
A254_RS04225	COG0316	Belongs to the HesB IscA family
A254_RS04230	COG2151	metal-sulfur cluster biosynthetic enzyme
A254_RS04235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A254_RS04240	COG0719	Fe-S assembly protein
A254_RS04245	COG0396	ATPase activity
A254_RS04250	COG0719	Fe-S assembly protein
A254_RS04260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A254_RS04265	COG0287	Prephenate dehydrogenase
A254_RS04285	COG2884	Cell division ATP-binding protein ftsE
A254_RS04300	COG2095	MarC family integral membrane protein
A254_RS04305	COG0187	DNA topoisomerase II activity
A254_RS04315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A254_RS04320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A254_RS04330	COG0842	Transport permease protein
A254_RS04345	COG0248	Ppx GppA phosphatase
A254_RS04350	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A254_RS04355	COG5001	Diguanylate cyclase
A254_RS04470	COG1621	beta-fructofuranosidase activity
A254_RS04475	COG1621	beta-fructofuranosidase activity
A254_RS04485	COG1522	sequence-specific DNA binding
A254_RS04490	COG1794	racemase activity, acting on amino acids and derivatives
A254_RS04495	COG0837	glucose binding
A254_RS04500	COG0129	dihydroxy-acid dehydratase activity
A254_RS04505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A254_RS04510	COG0477	Major facilitator Superfamily
A254_RS04515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A254_RS04520	COG0343	queuine tRNA-ribosyltransferase activity
A254_RS04525	COG0556	nucleotide-excision repair
A254_RS04535	COG0772	Belongs to the SEDS family
A254_RS04560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A254_RS04585	COG1678	Uncharacterized ACR, COG1678
A254_RS04590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A254_RS04595	COG1923	regulation of RNA biosynthetic process
A254_RS04600	COG0004	ammonium transporteR
A254_RS04610	COG0312	modulator of DNA gyrase
A254_RS04620	COG0436	Aminotransferase
A254_RS04640	COG2894	cell division
A254_RS04645	COG0352	thiamine-phosphate diphosphorylase activity
A254_RS04650	COG3108	Peptidase M15
A254_RS04660	COG0483	inositol monophosphate 1-phosphatase activity
A254_RS04665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A254_RS04670	COG0626	cystathionine gamma-synthase activity
A254_RS04675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A254_RS04685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A254_RS04690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A254_RS04695	COG0196	riboflavin kinase activity
A254_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
A254_RS04725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A254_RS04735	COG1473	amidohydrolase
A254_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
A254_RS04765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A254_RS04780	COG1570	exodeoxyribonuclease VII activity
A254_RS04785	COG0151	Belongs to the GarS family
A254_RS04795	COG1253	flavin adenine dinucleotide binding
A254_RS04800	COG0590	tRNA wobble adenosine to inosine editing
A254_RS04805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A254_RS04810	COG2814	Major facilitator Superfamily
A254_RS04815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A254_RS04820	COG2733	membrane
A254_RS04845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A254_RS04855	COG1278	Cold shock
A254_RS04875	COG1137	ATPase activity
A254_RS04880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A254_RS04885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A254_RS04890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A254_RS04940	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A254_RS04945	COG4133	protoheme IX ABC transporter activity
A254_RS04960	COG0277	FAD linked oxidase domain protein
A254_RS04965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A254_RS04995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A254_RS05000	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A254_RS05005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A254_RS05010	COG0776	regulation of translation
A254_RS05020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A254_RS05025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A254_RS05030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A254_RS05035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A254_RS05040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A254_RS05045	COG0489	protein tyrosine kinase activity
A254_RS05050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A254_RS05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A254_RS05075	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A254_RS05080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A254_RS05090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A254_RS05090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A254_RS05095	COG4221	oxidoreductase activity
A254_RS05100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A254_RS05105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A254_RS05105	COG2813	Specifically methylates the guanine in position
A254_RS05125	COG1329	Transcriptional regulator
A254_RS05130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A254_RS05135	COG4581	dead DEAH box helicase
A254_RS05140	COG0739	heme binding
A254_RS05150	COG0534	Mate efflux family protein
A254_RS05160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A254_RS05165	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A254_RS05175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A254_RS05180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A254_RS05195	COG0789	Transcriptional regulator
A254_RS05200	COG0840	transmembrane signaling receptor activity
A254_RS05205	COG0512	Glutamine amidotransferase of anthranilate synthase
A254_RS05210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A254_RS05215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A254_RS05225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A254_RS05240	COG1530	ribonuclease E activity
A254_RS05260	COG1760	l-serine dehydratase
A254_RS05275	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A254_RS05280	COG0215	cysteine-tRNA ligase activity
A254_RS05290	COG0488	(ABC) transporter
A254_RS05295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A254_RS05300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A254_RS05305	COG1830	Aldolase
A254_RS05315	COG0126	phosphoglycerate kinase activity
A254_RS05320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A254_RS05345	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A254_RS05355	COG0584	glycerophosphoryl diester phosphodiesterase
A254_RS05360	COG2885	chlorophyll binding
A254_RS05365	COG0823	Involved in the tonB-independent uptake of proteins
A254_RS05375	COG0848	biopolymer transport protein
A254_RS05380	COG0811	peptide transport
A254_RS05385	COG0824	Thioesterase
A254_RS05390	COG2255	four-way junction helicase activity
A254_RS05395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A254_RS05405	COG0632	four-way junction helicase activity
A254_RS05410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A254_RS05415	COG0217	transcriptional regulatory protein
A254_RS05420	COG3750	Belongs to the UPF0335 family
A254_RS05425	COG0469	pyruvate kinase activity
A254_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A254_RS05455	COG1131	(ABC) transporter
A254_RS05470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A254_RS05525	COG0671	phosphoesterase, PA-phosphatase related
A254_RS05545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A254_RS05560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A254_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
A254_RS05580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A254_RS05585	COG1151	hydroxylamine reductase activity
A254_RS05590	COG1959	2 iron, 2 sulfur cluster binding
A254_RS05595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A254_RS05600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A254_RS05600	COG0512	Glutamine amidotransferase of anthranilate synthase
A254_RS05605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A254_RS05615	COG0488	(ABC) transporter
A254_RS05640	COG0066	3-isopropylmalate dehydratase activity
A254_RS05645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A254_RS05650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A254_RS05680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A254_RS05690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A254_RS05700	COG1028	Short-chain dehydrogenase reductase Sdr
A254_RS05720	COG0840	transmembrane signaling receptor activity
A254_RS05730	COG2198	Histidine kinase
A254_RS05730	COG0643	Histidine kinase
A254_RS05735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A254_RS05740	COG2201	protein-glutamate methylesterase activity
A254_RS05745	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A254_RS05750	COG0745	RESPONSE REGULATOR receiver
A254_RS05755	COG0835	chemotaxis
A254_RS05760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A254_RS05765	COG1702	phosphate starvation-inducible protein PhoH
A254_RS05770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A254_RS05785	COG2999	glutathione oxidoreductase activity
A254_RS05825	COG1929	Belongs to the glycerate kinase type-1 family
A254_RS05840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A254_RS05845	COG0730	response to heat
A254_RS05850	COG1846	Transcriptional regulator
A254_RS05855	COG0596	Alpha beta hydrolase
A254_RS05860	COG2807	transmembrane transport
A254_RS05880	COG0424	maF-like protein
A254_RS05890	COG0237	dephospho-CoA kinase activity
A254_RS05895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A254_RS05900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A254_RS05905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A254_RS05920	COG2983	Belongs to the UPF0260 family
A254_RS05935	COG1715	Restriction endonuclease
A254_RS05940	COG0138	bifunctional purine biosynthesis protein purh
A254_RS05960	COG0247	lactate metabolic process
A254_RS05965	COG1139	Iron-sulfur cluster binding protein
A254_RS05980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A254_RS05990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A254_RS05995	COG1420	regulation of RNA biosynthetic process
A254_RS06000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A254_RS06005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A254_RS06010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A254_RS06025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A254_RS06030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A254_RS06035	COG0175	sulfate reduction
A254_RS06040	COG1648	precorrin-2 dehydrogenase activity
A254_RS06040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A254_RS06045	COG0175	sulfate reduction
A254_RS06060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A254_RS06070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A254_RS06080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A254_RS06095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A254_RS06100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A254_RS06105	COG4771	TonB-dependent receptor
A254_RS06110	COG0667	Aldo Keto reductase
A254_RS06115	COG3386	PFAM SMP-30 Gluconolaconase
A254_RS06120	COG0445	tRNA wobble uridine modification
A254_RS06125	COG0357	Ribosomal RNA small subunit methyltransferase G
A254_RS06140	COG0477	Major facilitator Superfamily
A254_RS06150	COG2423	ornithine cyclodeaminase activity
A254_RS06155	COG0583	DNA-binding transcription factor activity
A254_RS06165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A254_RS06170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A254_RS06190	COG0658	competence protein
A254_RS06190	COG2333	competence protein COMEC
A254_RS06195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A254_RS06200	COG0372	Belongs to the citrate synthase family
A254_RS06205	COG5002	protein histidine kinase activity
A254_RS06230	COG0438	transferase activity, transferring glycosyl groups
A254_RS06230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A254_RS06235	COG0497	DNA recombination
A254_RS06245	COG0459	protein refolding
A254_RS06250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A254_RS06255	COG0616	signal peptide processing
A254_RS06260	COG0826	peptidase U32
A254_RS06270	COG1368	sulfuric ester hydrolase activity
A254_RS06295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A254_RS06300	COG0156	8-amino-7-oxononanoate synthase activity
A254_RS06310	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A254_RS06310	COG4106	trans-aconitate 2-methyltransferase activity
A254_RS06320	COG0189	ligase activity
A254_RS06325	COG0012	GTP binding
A254_RS06330	COG0193	aminoacyl-tRNA hydrolase activity
A254_RS06335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A254_RS06350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A254_RS06355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A254_RS06360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A254_RS06365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A254_RS06370	COG0181	hydroxymethylbilane synthase activity
A254_RS06385	COG0416	fatty acid biosynthetic process
A254_RS06390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A254_RS06400	COG1862	Preprotein translocase
A254_RS06405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A254_RS06415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A254_RS06435	COG0612	Peptidase, M16
A254_RS06450	COG1335	isochorismatase
A254_RS06455	COG3180	Ammonia monooxygenase
A254_RS06460	COG1902	pentaerythritol trinitrate reductase activity
A254_RS06465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A254_RS06470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A254_RS06475	COG3180	Ammonia monooxygenase
A254_RS06490	COG0113	porphobilinogen synthase activity
A254_RS06495	COG0525	valine-tRNA ligase activity
A254_RS06520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A254_RS06530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A254_RS06550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A254_RS06600	COG2070	2-Nitropropane dioxygenase
A254_RS06670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A254_RS06675	COG0716	FMN binding
A254_RS06695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A254_RS06700	COG1120	ATPase activity
A254_RS06705	COG2824	Alkylphosphonate utilization operon protein PhnA
A254_RS06710	COG0673	inositol 2-dehydrogenase activity
A254_RS06730	COG3585	molybdate ion transport
A254_RS06745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A254_RS06750	COG1104	cysteine desulfurase activity
A254_RS06780	COG1433	Dinitrogenase iron-molybdenum cofactor
A254_RS06785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A254_RS06790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A254_RS06795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A254_RS06800	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A254_RS06805	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A254_RS06810	COG4774	siderophore transport
A254_RS06820	COG5554	nitrogen fixation
A254_RS06830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A254_RS06835	COG0535	radical SAM domain protein
A254_RS06840	COG3604	Transcriptional regulator
A254_RS06850	COG4657	Part of a membrane complex involved in electron transport
A254_RS06860	COG4656	Part of a membrane complex involved in electron transport
A254_RS06865	COG4658	electron transport chain
A254_RS06890	COG0110	maltose O-acetyltransferase activity
A254_RS06895	COG0546	phosphoglycolate phosphatase activity
A254_RS06900	COG0531	amino acid
A254_RS06905	COG0776	regulation of translation
A254_RS06915	COG0539	negative regulation of cytoplasmic translation
A254_RS06920	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A254_RS06925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A254_RS06940	COG0583	DNA-binding transcription factor activity
A254_RS06945	COG0129	dihydroxy-acid dehydratase activity
A254_RS06955	COG1132	(ABC) transporter
A254_RS06975	COG0668	transmembrane transport
A254_RS07015	COG0656	L-ascorbic acid biosynthetic process
A254_RS07020	COG0604	alcohol dehydrogenase
A254_RS07020	COG3321	synthase
A254_RS07025	COG1979	alcohol dehydrogenase
A254_RS07030	COG0165	Argininosuccinate lyase
A254_RS07040	COG0019	diaminopimelate decarboxylase activity
A254_RS07045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A254_RS07055	COG2989	Protein conserved in bacteria
A254_RS07065	COG0792	nuclease activity
A254_RS07070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A254_RS07080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A254_RS07085	COG3265	gluconokinase activity
A254_RS07090	COG2610	gluconate transmembrane transporter activity
A254_RS07095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A254_RS07100	COG1012	belongs to the aldehyde dehydrogenase family
A254_RS07125	COG2853	Lipoprotein
A254_RS07145	COG1410	methionine synthase
A254_RS07145	COG0646	methionine synthase
A254_RS07155	COG0481	GTPase activity
A254_RS07165	COG3275	phosphorelay sensor kinase activity
A254_RS07170	COG3279	Response regulator of the LytR AlgR family
A254_RS07185	COG0583	DNA-binding transcription factor activity
A254_RS07195	COG1045	serine acetyltransferase
A254_RS07210	COG0436	Aminotransferase
A254_RS07215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A254_RS07220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A254_RS07235	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A254_RS07245	COG1758	RNA polymerase activity
A254_RS07250	COG1940	carbohydrate kinase activity
A254_RS07280	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A254_RS07290	COG0628	permease
A254_RS07295	COG0681	Belongs to the peptidase S26 family
A254_RS07300	COG0736	holo-[acyl-carrier-protein] synthase activity
A254_RS07305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A254_RS07310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A254_RS07325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A254_RS07330	COG1674	ftsk spoiiie
A254_RS07335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A254_RS07345	COG0708	Exodeoxyribonuclease III
A254_RS07355	COG1733	regulation of RNA biosynthetic process
A254_RS07375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A254_RS07380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A254_RS07385	COG1295	ribonuclease BN
A254_RS07390	COG0484	heat shock protein binding
A254_RS07395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A254_RS07400	COG0354	folic acid binding
A254_RS07405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A254_RS07415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A254_RS07425	COG0252	asparaginase activity
A254_RS07435	COG2985	domain, Protein
A254_RS07450	COG0077	Prephenate dehydratase
A254_RS07455	COG1194	a g-specific adenine glycosylase
A254_RS07470	COG0656	L-ascorbic acid biosynthetic process
A254_RS07490	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A254_RS07500	COG0793	Belongs to the peptidase S41A family
A254_RS07510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A254_RS07515	COG0799	negative regulation of ribosome biogenesis
A254_RS07520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A254_RS07525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A254_RS07540	COG0037	tRNA processing
A254_RS07560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A254_RS07575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A254_RS07585	COG3386	PFAM SMP-30 Gluconolaconase
A254_RS07590	COG1573	uracil-dna glycosylase
A254_RS07605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A254_RS07615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A254_RS07620	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A254_RS07630	COG0180	Tryptophanyl-tRNA synthetase
A254_RS07635	COG0728	peptidoglycan biosynthetic process
A254_RS07640	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A254_RS07655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A254_RS07670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A254_RS07675	COG4774	siderophore transport
A254_RS07695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A254_RS07700	COG0706	membrane insertase activity
A254_RS07705	COG0594	ribonuclease P activity
A254_RS07715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A254_RS07730	COG0505	Belongs to the CarA family
A254_RS07740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A254_RS07770	COG0148	phosphopyruvate hydratase activity
A254_RS07780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A254_RS07785	COG0022	dehydrogenase e1 component
A254_RS07785	COG0508	dehydrogenase complex catalyzes the overall conversion of
A254_RS07795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A254_RS07795	COG3453	Protein conserved in bacteria
A254_RS07805	COG0328	RNA-DNA hybrid ribonuclease activity
A254_RS07810	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A254_RS07820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A254_RS07825	COG1454	alcohol dehydrogenase
A254_RS07840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A254_RS07845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A254_RS07850	COG1127	ABC transporter
A254_RS07855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A254_RS07860	COG0730	response to heat
A254_RS07865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A254_RS07880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A254_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
A254_RS07945	COG4221	oxidoreductase activity
A254_RS07965	COG1294	oxidase, subunit
A254_RS07970	COG1271	oxidase subunit
A254_RS07985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A254_RS08000	COG1742	UPF0060 membrane protein
A254_RS08020	COG1051	belongs to the nudix hydrolase family
A254_RS08025	COG4221	oxidoreductase activity
A254_RS08030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A254_RS08045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A254_RS08050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A254_RS08055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A254_RS08060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A254_RS08070	COG1657	PFAM Prenyltransferase squalene oxidase
A254_RS08095	COG0629	single-stranded DNA binding
A254_RS08125	COG0047	phosphoribosylformylglycinamidine synthase activity
A254_RS08130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A254_RS08135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A254_RS08135	COG0517	IMP dehydrogenase activity
A254_RS08140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A254_RS08155	COG1538	Outer membrane efflux protein
A254_RS08180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A254_RS08190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A254_RS08195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A254_RS08200	COG0072	phenylalanine-tRNA ligase activity
A254_RS08200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A254_RS08205	COG5265	(ABC) transporter
A254_RS08215	COG2890	protein-(glutamine-N5) methyltransferase activity
A254_RS08220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A254_RS08225	COG0124	histidyl-tRNA synthetase
A254_RS08230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A254_RS08250	COG0131	Imidazoleglycerol-phosphate dehydratase
A254_RS08255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A254_RS08260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A254_RS08265	COG0107	imidazoleglycerol-phosphate synthase activity
A254_RS08270	COG0140	phosphoribosyl-ATP diphosphatase activity
A254_RS08280	COG0531	amino acid
A254_RS08285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A254_RS08290	COG2096	Adenosyltransferase
A254_RS08295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A254_RS08315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A254_RS08320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A254_RS08325	COG2199	diguanylate cyclase activity
A254_RS08325	COG2200	EAL domain
A254_RS08340	COG0210	DNA helicase
A254_RS08355	COG0045	succinate-CoA ligase (ADP-forming) activity
A254_RS08370	COG0363	glucosamine-6-phosphate deaminase activity
A254_RS08390	COG1217	gtp-binding protein TYPA
A254_RS08405	COG0814	amino acid
A254_RS08430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A254_RS08435	COG2814	Major facilitator Superfamily
A254_RS08445	COG0415	Belongs to the DNA photolyase family
A254_RS08450	COG0246	Mannitol dehydrogenase
A254_RS08470	COG0752	glycyl-tRNA synthetase alpha subunit
A254_RS08480	COG2244	polysaccharide biosynthetic process
A254_RS08500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A254_RS08520	COG0495	leucyl-tRNA aminoacylation
A254_RS08555	COG1597	lipid kinase activity
A254_RS08560	COG2003	Belongs to the UPF0758 family
A254_RS08565	COG0352	thiamine-phosphate diphosphorylase activity
A254_RS08575	COG0612	Peptidase, M16
A254_RS08580	COG0612	Peptidase, M16
A254_RS08585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A254_RS08590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A254_RS08595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A254_RS08605	COG0513	Belongs to the DEAD box helicase family
A254_RS08620	COG1214	PFAM Peptidase M22, glycoprotease
A254_RS08630	COG4957	zinc ion binding
A254_RS08640	COG2193	ferroxidase activity
A254_RS08660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A254_RS08665	COG0596	Alpha beta hydrolase
A254_RS08670	COG0784	Response regulator, receiver
A254_RS08680	COG0739	heme binding
A254_RS08685	COG0316	Belongs to the HesB IscA family
A254_RS08690	COG0708	Exodeoxyribonuclease III
A254_RS08750	COG0405	Gamma-glutamyltransferase
A254_RS08770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A254_RS08775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A254_RS08805	COG0571	ribonuclease III activity
A254_RS08815	COG0300	oxidoreductase activity
A254_RS08835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A254_RS08845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A254_RS08865	COG3961	Belongs to the TPP enzyme family
A254_RS08870	COG0268	Binds directly to 16S ribosomal RNA
A254_RS09070	COG0308	aminopeptidase N
A254_RS09165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A254_RS09270	COG0308	aminopeptidase N
A254_RS09385	COG0642	Histidine kinase
A254_RS09555	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A254_RS09690	COG2353	YceI-like domain