locus-tag	class	description
ZCP4_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZCP4_RS00020	COG0488	(ABC) transporter
ZCP4_RS00025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZCP4_RS00025	COG2885	chlorophyll binding
ZCP4_RS00030	COG4702	Belongs to the UPF0303 family
ZCP4_RS00035	COG0670	Belongs to the BI1 family
ZCP4_RS00045	COG1058	Belongs to the CinA family
ZCP4_RS00045	COG1546	Belongs to the CinA family
ZCP4_RS00050	COG0024	Methionine aminopeptidase
ZCP4_RS00065	COG0308	aminopeptidase N
ZCP4_RS00090	COG2321	neutral zinc metallopeptidase
ZCP4_RS00100	COG1280	lysine exporter protein (LysE YggA)
ZCP4_RS00105	COG1741	Belongs to the pirin family
ZCP4_RS00110	COG0583	DNA-binding transcription factor activity
ZCP4_RS00115	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZCP4_RS00120	COG2353	YceI-like domain
ZCP4_RS00125	COG0668	transmembrane transport
ZCP4_RS00130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZCP4_RS00135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZCP4_RS00150	COG1660	Displays ATPase and GTPase activities
ZCP4_RS00155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZCP4_RS00160	COG0642	Histidine kinase
ZCP4_RS00165	COG0745	RESPONSE REGULATOR receiver
ZCP4_RS00175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZCP4_RS00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZCP4_RS00190	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZCP4_RS00195	COG2244	polysaccharide biosynthetic process
ZCP4_RS00205	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZCP4_RS00210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZCP4_RS00215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZCP4_RS00220	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ZCP4_RS00225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZCP4_RS00235	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ZCP4_RS00235	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ZCP4_RS00240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZCP4_RS00255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZCP4_RS00260	COG0321	lipoyl(octanoyl) transferase activity
ZCP4_RS00280	COG0602	queuosine metabolic process
ZCP4_RS00285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZCP4_RS00295	COG2261	transglycosylase associated protein
ZCP4_RS00300	COG2223	nitrite transmembrane transporter activity
ZCP4_RS00325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZCP4_RS00330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZCP4_RS00335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZCP4_RS00350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZCP4_RS00360	COG1012	belongs to the aldehyde dehydrogenase family
ZCP4_RS00370	COG0156	8-amino-7-oxononanoate synthase activity
ZCP4_RS00385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZCP4_RS00385	COG0519	Catalyzes the synthesis of GMP from XMP
ZCP4_RS00395	COG4948	Mandelate Racemase Muconate Lactonizing
ZCP4_RS00400	COG1116	anion transmembrane transporter activity
ZCP4_RS00405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZCP4_RS00410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ZCP4_RS00415	COG4771	TonB-dependent receptor
ZCP4_RS00420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZCP4_RS00425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ZCP4_RS00430	COG1138	Cytochrome C-type biogenesis protein
ZCP4_RS00435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZCP4_RS00440	COG3088	subunit of a heme lyase
ZCP4_RS00470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZCP4_RS00480	COG2866	Carboxypeptidase
ZCP4_RS00485	COG0588	phosphoglycerate mutase activity
ZCP4_RS00490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZCP4_RS00495	COG1064	alcohol dehydrogenase
ZCP4_RS00505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZCP4_RS00550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZCP4_RS00550	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ZCP4_RS00555	COG0302	gtp cyclohydrolase
ZCP4_RS00560	COG4948	Mandelate Racemase Muconate Lactonizing
ZCP4_RS00565	COG0359	binds to the 23S rRNA
ZCP4_RS00570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZCP4_RS00575	COG0360	Binds together with S18 to 16S ribosomal RNA
ZCP4_RS00585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZCP4_RS00600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZCP4_RS00605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZCP4_RS00610	COG0805	protein transport
ZCP4_RS00630	COG0513	Belongs to the DEAD box helicase family
ZCP4_RS00640	COG0166	Belongs to the GPI family
ZCP4_RS00655	COG3158	transport of potassium into the cell
ZCP4_RS00670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZCP4_RS00690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZCP4_RS00695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZCP4_RS00705	COG0156	8-amino-7-oxononanoate synthase activity
ZCP4_RS00710	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZCP4_RS00715	COG2814	Major facilitator Superfamily
ZCP4_RS00720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ZCP4_RS00725	COG0758	DNA mediated transformation
ZCP4_RS00730	COG1754	DNA topoisomerase type I activity
ZCP4_RS00730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZCP4_RS00735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZCP4_RS00740	COG0756	dUTP diphosphatase activity
ZCP4_RS00745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZCP4_RS00750	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ZCP4_RS00755	COG2226	methyltransferase
ZCP4_RS00765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZCP4_RS00790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZCP4_RS00805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZCP4_RS00810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZCP4_RS00820	COG2205	protein histidine kinase activity
ZCP4_RS00835	COG3724	N-succinylarginine dihydrolase activity
ZCP4_RS00840	COG1472	Belongs to the glycosyl hydrolase 3 family
ZCP4_RS00850	COG2971	BadF BadG BcrA BcrD
ZCP4_RS00860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZCP4_RS00865	COG1040	competence protein
ZCP4_RS00870	COG0745	RESPONSE REGULATOR receiver
ZCP4_RS00875	COG0704	Plays a role in the regulation of phosphate uptake
ZCP4_RS00885	COG0688	phosphatidylethanolamine metabolic process
ZCP4_RS00890	COG1183	phosphatidylcholine synthase activity
ZCP4_RS00895	COG1794	racemase activity, acting on amino acids and derivatives
ZCP4_RS00905	COG0052	Belongs to the universal ribosomal protein uS2 family
ZCP4_RS00910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZCP4_RS00915	COG0528	UMP kinase activity
ZCP4_RS00920	COG0233	cytoplasmic translational termination
ZCP4_RS00925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZCP4_RS00930	COG0575	Belongs to the CDS family
ZCP4_RS00935	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZCP4_RS00940	COG0750	zinc metalloprotease
ZCP4_RS00945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZCP4_RS00955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZCP4_RS00960	COG0254	rRNA binding
ZCP4_RS00975	COG0492	ferredoxin-NADP+ reductase activity
ZCP4_RS00980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZCP4_RS00985	COG0440	acetolactate synthase activity
ZCP4_RS00990	COG0028	Belongs to the TPP enzyme family
ZCP4_RS00995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZCP4_RS01005	COG1858	cytochrome C peroxidase
ZCP4_RS01010	COG0312	modulator of DNA gyrase
ZCP4_RS01020	COG0288	reversible hydration of carbon dioxide
ZCP4_RS01025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZCP4_RS01030	COG2867	negative regulation of translational initiation
ZCP4_RS01035	COG1058	Belongs to the CinA family
ZCP4_RS01035	COG1546	Belongs to the CinA family
ZCP4_RS01045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZCP4_RS01045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZCP4_RS01055	COG2204	response regulator
ZCP4_RS01060	COG5000	phosphorelay sensor kinase activity
ZCP4_RS01065	COG2204	response regulator
ZCP4_RS01075	COG0776	regulation of translation
ZCP4_RS01100	COG1968	undecaprenyl-diphosphatase activity
ZCP4_RS01110	COG1573	uracil-dna glycosylase
ZCP4_RS01115	COG1252	NADH dehydrogenase
ZCP4_RS01120	COG2917	probably involved in intracellular septation
ZCP4_RS01125	COG2807	transmembrane transport
ZCP4_RS01135	COG1522	sequence-specific DNA binding
ZCP4_RS01150	COG2205	protein histidine kinase activity
ZCP4_RS01155	COG0802	atpase or kinase
ZCP4_RS01160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ZCP4_RS01170	COG1074	ATP-dependent DNA helicase activity
ZCP4_RS01180	COG0557	exoribonuclease II activity
ZCP4_RS01185	COG3956	TIGRFAM MazG family protein
ZCP4_RS01195	COG0084	hydrolase, TatD family'
ZCP4_RS01205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZCP4_RS01210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZCP4_RS01215	COG1686	Belongs to the peptidase S11 family
ZCP4_RS01225	COG2951	lytic endotransglycosylase activity
ZCP4_RS01230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ZCP4_RS01235	COG0457	Tetratricopeptide repeat
ZCP4_RS01240	COG1215	transferase activity, transferring glycosyl groups
ZCP4_RS01245	COG1215	transferase activity, transferring glycosyl groups
ZCP4_RS01260	COG0335	large ribosomal subunit rRNA binding
ZCP4_RS01265	COG0336	Belongs to the RNA methyltransferase TrmD family
ZCP4_RS01270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZCP4_RS01275	COG0228	four-way junction DNA binding
ZCP4_RS01280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZCP4_RS01285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZCP4_RS01290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZCP4_RS01295	COG0552	protein localization to endoplasmic reticulum
ZCP4_RS01300	COG0484	heat shock protein binding
ZCP4_RS01330	COG1842	Phage shock protein A
ZCP4_RS01340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZCP4_RS01360	COG0617	tRNA 3'-terminal CCA addition
ZCP4_RS01365	COG5001	Diguanylate cyclase
ZCP4_RS01370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZCP4_RS01375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZCP4_RS01380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZCP4_RS01385	COG0581	inorganic phosphate transmembrane transporter activity
ZCP4_RS01390	COG0573	inorganic phosphate transmembrane transporter activity
ZCP4_RS01395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZCP4_RS01405	COG1970	mechanosensitive ion channel activity
ZCP4_RS01415	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ZCP4_RS01435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZCP4_RS01445	COG0137	argininosuccinate synthase activity
ZCP4_RS01455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ZCP4_RS01460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZCP4_RS01490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZCP4_RS01495	COG1104	cysteine desulfurase activity
ZCP4_RS01500	COG2945	thiolester hydrolase activity
ZCP4_RS01505	COG0019	diaminopimelate decarboxylase activity
ZCP4_RS01515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZCP4_RS01520	COG1127	ABC transporter
ZCP4_RS01535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZCP4_RS01540	COG0424	maF-like protein
ZCP4_RS01550	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ZCP4_RS01570	COG0277	FAD linked oxidase domain protein
ZCP4_RS01575	COG3781	membrane
ZCP4_RS01580	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZCP4_RS01590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZCP4_RS01595	COG0352	thiamine-phosphate diphosphorylase activity
ZCP4_RS01595	COG0351	phosphomethylpyrimidine kinase
ZCP4_RS01600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZCP4_RS01605	COG3104	oligopeptide transport
ZCP4_RS01610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZCP4_RS01615	COG0009	L-threonylcarbamoyladenylate synthase
ZCP4_RS01620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZCP4_RS01625	COG0800	Aldolase
ZCP4_RS01630	COG0668	transmembrane transport
ZCP4_RS01645	COG0071	Belongs to the small heat shock protein (HSP20) family
ZCP4_RS01660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZCP4_RS01665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZCP4_RS01680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZCP4_RS01685	COG4172	Belongs to the ABC transporter superfamily
ZCP4_RS01695	COG4206	TonB-dependent receptor
ZCP4_RS01705	COG0667	Aldo Keto reductase
ZCP4_RS01735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZCP4_RS01745	COG2252	PERMEase
ZCP4_RS01755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ZCP4_RS01760	COG2814	Major facilitator Superfamily
ZCP4_RS01765	COG1566	PFAM secretion protein HlyD family protein
ZCP4_RS01775	COG1309	transcriptional regulator
ZCP4_RS01780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ZCP4_RS01795	COG2857	Cytochrome c1
ZCP4_RS01800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZCP4_RS01805	COG0723	plastoquinol--plastocyanin reductase activity
ZCP4_RS01820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZCP4_RS01825	COG0408	coproporphyrinogen oxidase activity
ZCP4_RS01835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZCP4_RS01840	COG0740	serine-type endopeptidase activity
ZCP4_RS01850	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZCP4_RS01870	COG1621	beta-fructofuranosidase activity
ZCP4_RS01885	COG1846	Transcriptional regulator
ZCP4_RS01890	COG0402	S-adenosylhomocysteine deaminase activity
ZCP4_RS01895	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ZCP4_RS01900	COG1448	Aminotransferase
ZCP4_RS01905	COG0697	spore germination
ZCP4_RS01935	COG3191	aminopeptidase activity
ZCP4_RS01940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZCP4_RS01950	COG1278	Cold shock
ZCP4_RS01955	COG0653	protein targeting
ZCP4_RS01960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZCP4_RS02000	COG2217	Heavy metal translocating P-type atpase
ZCP4_RS02005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZCP4_RS02010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZCP4_RS02050	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZCP4_RS02060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZCP4_RS02075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZCP4_RS02075	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZCP4_RS02110	COG1199	ATP-dependent helicase activity
ZCP4_RS02110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZCP4_RS02115	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZCP4_RS02140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZCP4_RS02145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZCP4_RS02150	COG0840	transmembrane signaling receptor activity
ZCP4_RS02155	COG2198	Histidine kinase
ZCP4_RS02155	COG0643	Histidine kinase
ZCP4_RS02160	COG2201	protein-glutamate methylesterase activity
ZCP4_RS02175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZCP4_RS02190	COG1657	PFAM Prenyltransferase squalene oxidase
ZCP4_RS02195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ZCP4_RS02200	COG1562	ergosterol biosynthetic process
ZCP4_RS02205	COG1562	ergosterol biosynthetic process
ZCP4_RS02210	COG1215	transferase activity, transferring glycosyl groups
ZCP4_RS02215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZCP4_RS02225	COG0305	Participates in initiation and elongation during chromosome replication
ZCP4_RS02230	COG0295	cytidine deaminase activity
ZCP4_RS02235	COG0717	Belongs to the dCTP deaminase family
ZCP4_RS02240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZCP4_RS02245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZCP4_RS02255	COG1104	cysteine desulfurase activity
ZCP4_RS02265	COG1722	exodeoxyribonuclease VII activity
ZCP4_RS02270	COG0142	geranyltranstransferase activity
ZCP4_RS02275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZCP4_RS02285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZCP4_RS02290	COG0259	pyridoxamine-phosphate oxidase activity
ZCP4_RS02315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZCP4_RS02325	COG0018	arginyl-trna synthetase
ZCP4_RS02330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZCP4_RS02335	COG0038	chloride channel
ZCP4_RS02345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZCP4_RS02350	COG0849	cell division
ZCP4_RS02355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZCP4_RS02360	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZCP4_RS02365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZCP4_RS02370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZCP4_RS02375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZCP4_RS02385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZCP4_RS02390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZCP4_RS02400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZCP4_RS02415	COG0275	rRNA processing
ZCP4_RS02435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZCP4_RS02440	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZCP4_RS02445	COG0720	synthase
ZCP4_RS02460	COG1322	Protein conserved in bacteria
ZCP4_RS02465	COG0242	peptide deformylase activity
ZCP4_RS02470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZCP4_RS02475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZCP4_RS02480	COG0101	tRNA pseudouridine synthase activity
ZCP4_RS02485	COG1872	DUF167
ZCP4_RS02490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZCP4_RS02495	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZCP4_RS02525	COG0842	Transport permease protein
ZCP4_RS02525	COG1129	ABC transporter
ZCP4_RS02530	COG0842	Transport permease protein
ZCP4_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
ZCP4_RS02550	COG1505	serine-type exopeptidase activity
ZCP4_RS02560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZCP4_RS02565	COG0540	Belongs to the ATCase OTCase family
ZCP4_RS02595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZCP4_RS02600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZCP4_RS02605	COG0154	amidase activity
ZCP4_RS02610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZCP4_RS02615	COG0583	DNA-binding transcription factor activity
ZCP4_RS02620	COG1538	Outer membrane efflux protein
ZCP4_RS02635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZCP4_RS02655	COG2239	Acts as a magnesium transporter
ZCP4_RS02660	COG0482	sulfurtransferase activity
ZCP4_RS02675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ZCP4_RS02680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZCP4_RS02700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZCP4_RS02725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ZCP4_RS02740	COG0564	pseudouridine synthase activity
ZCP4_RS02745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZCP4_RS02780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZCP4_RS02790	COG2329	Antibiotic biosynthesis monooxygenase
ZCP4_RS02795	COG2022	thiamine diphosphate biosynthetic process
ZCP4_RS02800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZCP4_RS02805	COG0511	ligase activity, forming carbon-carbon bonds
ZCP4_RS02810	COG0439	Biotin carboxylase
ZCP4_RS02825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZCP4_RS02830	COG0085	RNA polymerase activity
ZCP4_RS02840	COG0222	ribosome binding
ZCP4_RS02845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZCP4_RS02850	COG0081	regulation of translation
ZCP4_RS02855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZCP4_RS02865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ZCP4_RS02875	COG3590	peptidase
ZCP4_RS02880	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZCP4_RS02885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZCP4_RS02890	COG0741	lytic transglycosylase activity
ZCP4_RS02900	COG2326	polyphosphate kinase activity
ZCP4_RS02905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZCP4_RS02910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ZCP4_RS02915	COG0248	Ppx GppA phosphatase
ZCP4_RS02920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZCP4_RS02935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZCP4_RS02940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZCP4_RS02945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZCP4_RS02960	COG0318	PFAM AMP-dependent synthetase and ligase
ZCP4_RS02980	COG2076	Multidrug Resistance protein
ZCP4_RS03010	COG1764	response to oxidative stress
ZCP4_RS03015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZCP4_RS03020	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZCP4_RS03025	COG0673	inositol 2-dehydrogenase activity
ZCP4_RS03030	COG0679	Auxin Efflux Carrier
ZCP4_RS03080	COG0473	3-isopropylmalate dehydrogenase activity
ZCP4_RS03090	COG0583	DNA-binding transcription factor activity
ZCP4_RS03100	COG1381	Involved in DNA repair and RecF pathway recombination
ZCP4_RS03105	COG0322	excinuclease ABC activity
ZCP4_RS03110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZCP4_RS03115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZCP4_RS03125	COG0356	it plays a direct role in the translocation of protons across the membrane
ZCP4_RS03150	COG2003	Belongs to the UPF0758 family
ZCP4_RS03155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZCP4_RS03160	COG0484	heat shock protein binding
ZCP4_RS03165	COG0443	Heat shock 70 kDa protein
ZCP4_RS03180	COG3138	arginine N-succinyltransferase
ZCP4_RS03195	COG0726	polysaccharide deacetylase
ZCP4_RS03200	COG0628	permease
ZCP4_RS03215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZCP4_RS03220	COG1684	flagellar biosynthetic protein fliR
ZCP4_RS03225	COG1987	bacterial-type flagellum assembly
ZCP4_RS03245	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZCP4_RS03275	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZCP4_RS03285	COG1677	Flagellar hook-basal body complex protein FliE
ZCP4_RS03295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ZCP4_RS03315	COG0455	bacterial-type flagellum organization
ZCP4_RS03345	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZCP4_RS03360	COG1558	bacterial-type flagellum-dependent cell motility
ZCP4_RS03365	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZCP4_RS03370	COG1749	Flagellar hook protein flgE
ZCP4_RS03385	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ZCP4_RS03390	COG1706	bacterial-type flagellum-dependent cell motility
ZCP4_RS03430	COG0825	malonyl-CoA metabolic process
ZCP4_RS03435	COG4974	Belongs to the 'phage' integrase family
ZCP4_RS03445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZCP4_RS03450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZCP4_RS03465	COG1286	toxin biosynthetic process
ZCP4_RS03480	COG0284	orotidine-5'-phosphate decarboxylase activity
ZCP4_RS03485	COG0135	phosphoribosylanthranilate isomerase activity
ZCP4_RS03490	COG0133	tryptophan synthase activity
ZCP4_RS03495	COG0159	tryptophan synthase activity
ZCP4_RS03500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZCP4_RS03505	COG0285	dihydrofolate synthase activity
ZCP4_RS03510	COG2223	nitrite transmembrane transporter activity
ZCP4_RS03515	COG1301	dicarboxylic acid transport
ZCP4_RS03520	COG1187	pseudouridine synthase activity
ZCP4_RS03525	COG0742	ribosomal rna small subunit methyltransferase
ZCP4_RS03535	COG2999	glutathione oxidoreductase activity
ZCP4_RS03540	COG1116	anion transmembrane transporter activity
ZCP4_RS03545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZCP4_RS03555	COG2264	protein methyltransferase activity
ZCP4_RS03575	COG2814	Major facilitator Superfamily
ZCP4_RS03580	COG1643	Atp-dependent helicase
ZCP4_RS03585	COG0142	geranyltranstransferase activity
ZCP4_RS03590	COG1605	Chorismate mutase
ZCP4_RS03590	COG0287	Prephenate dehydrogenase
ZCP4_RS03595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZCP4_RS03605	COG2133	pyrroloquinoline quinone binding
ZCP4_RS03610	COG0779	Required for maturation of 30S ribosomal subunits
ZCP4_RS03625	COG3064	Membrane
ZCP4_RS03625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZCP4_RS03630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZCP4_RS03635	COG1435	thymidine kinase activity
ZCP4_RS03640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZCP4_RS03645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZCP4_RS03650	COG1185	polyribonucleotide nucleotidyltransferase activity
ZCP4_RS03660	COG0038	chloride channel
ZCP4_RS03665	COG0659	secondary active sulfate transmembrane transporter activity
ZCP4_RS03675	COG0134	indole-3-glycerol-phosphate synthase activity
ZCP4_RS03680	COG0538	isocitrate dehydrogenase activity
ZCP4_RS03685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ZCP4_RS03695	COG0203	ribosomal protein L17
ZCP4_RS03700	COG0202	RNA polymerase activity
ZCP4_RS03705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZCP4_RS03710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZCP4_RS03715	COG0563	adenylate kinase activity
ZCP4_RS03720	COG0201	protein transport
ZCP4_RS03725	COG0200	Binds to the 23S rRNA
ZCP4_RS03730	COG1841	ribosomal large subunit assembly
ZCP4_RS03735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZCP4_RS03740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZCP4_RS03745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZCP4_RS03750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZCP4_RS03755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZCP4_RS03760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZCP4_RS03765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZCP4_RS03770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZCP4_RS03775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZCP4_RS03780	COG0255	Belongs to the universal ribosomal protein uL29 family
ZCP4_RS03785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZCP4_RS03790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZCP4_RS03795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZCP4_RS03800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZCP4_RS03805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZCP4_RS03810	COG0089	rRNA binding
ZCP4_RS03815	COG0088	Forms part of the polypeptide exit tunnel
ZCP4_RS03820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZCP4_RS03825	COG0051	transcription antitermination factor activity, RNA binding
ZCP4_RS03830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZCP4_RS03835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZCP4_RS03840	COG0049	tRNA binding
ZCP4_RS03845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZCP4_RS03850	COG0671	phosphoesterase, PA-phosphatase related
ZCP4_RS03855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZCP4_RS03860	COG1607	acyl-coa hydrolase
ZCP4_RS03865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZCP4_RS03880	COG1956	GAF domain-containing protein
ZCP4_RS03890	COG0564	pseudouridine synthase activity
ZCP4_RS03895	COG0463	Glycosyl transferase, family 2
ZCP4_RS03915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZCP4_RS03920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZCP4_RS03925	COG0546	phosphoglycolate phosphatase activity
ZCP4_RS03945	COG0174	glutamine synthetase
ZCP4_RS03950	COG0347	Belongs to the P(II) protein family
ZCP4_RS03955	COG0006	proline dipeptidase activity
ZCP4_RS03985	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ZCP4_RS03990	COG1960	acyl-CoA dehydrogenase activity
ZCP4_RS04005	COG1494	fructose-1,6-bisphosphatase
ZCP4_RS04015	COG5002	protein histidine kinase activity
ZCP4_RS04035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZCP4_RS04035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZCP4_RS04050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZCP4_RS04060	COG0583	DNA-binding transcription factor activity
ZCP4_RS04075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZCP4_RS04085	COG0149	triose-phosphate isomerase activity
ZCP4_RS04095	COG0504	CTP synthase activity
ZCP4_RS04100	COG0442	prolyl-tRNA aminoacylation
ZCP4_RS04110	COG1136	(ABC) transporter
ZCP4_RS04115	COG1522	sequence-specific DNA binding
ZCP4_RS04125	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ZCP4_RS04130	COG1160	GTP binding
ZCP4_RS04160	COG1696	Membrane protein involved in D-alanine export
ZCP4_RS04175	COG1372	Participates in initiation and elongation during chromosome replication
ZCP4_RS04175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZCP4_RS04180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZCP4_RS04215	COG0194	GDP metabolic process
ZCP4_RS04225	COG2171	N-acyltransferase activity
ZCP4_RS04235	COG0316	Belongs to the HesB IscA family
ZCP4_RS04240	COG2151	metal-sulfur cluster biosynthetic enzyme
ZCP4_RS04245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZCP4_RS04250	COG0719	Fe-S assembly protein
ZCP4_RS04255	COG0396	ATPase activity
ZCP4_RS04260	COG0719	Fe-S assembly protein
ZCP4_RS04270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZCP4_RS04275	COG0287	Prephenate dehydrogenase
ZCP4_RS04295	COG2884	Cell division ATP-binding protein ftsE
ZCP4_RS04310	COG2095	MarC family integral membrane protein
ZCP4_RS04315	COG0187	DNA topoisomerase II activity
ZCP4_RS04325	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZCP4_RS04330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZCP4_RS04340	COG0842	Transport permease protein
ZCP4_RS04355	COG0248	Ppx GppA phosphatase
ZCP4_RS04360	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ZCP4_RS04365	COG5001	Diguanylate cyclase
ZCP4_RS04480	COG1621	beta-fructofuranosidase activity
ZCP4_RS04485	COG1621	beta-fructofuranosidase activity
ZCP4_RS04495	COG1522	sequence-specific DNA binding
ZCP4_RS04500	COG1794	racemase activity, acting on amino acids and derivatives
ZCP4_RS04505	COG0837	glucose binding
ZCP4_RS04510	COG0129	dihydroxy-acid dehydratase activity
ZCP4_RS04515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZCP4_RS04520	COG0477	Major facilitator Superfamily
ZCP4_RS04525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZCP4_RS04530	COG0343	queuine tRNA-ribosyltransferase activity
ZCP4_RS04535	COG0556	nucleotide-excision repair
ZCP4_RS04545	COG0772	Belongs to the SEDS family
ZCP4_RS04570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZCP4_RS04595	COG1678	Uncharacterized ACR, COG1678
ZCP4_RS04600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZCP4_RS04605	COG1923	regulation of RNA biosynthetic process
ZCP4_RS04610	COG0004	ammonium transporteR
ZCP4_RS04620	COG0312	modulator of DNA gyrase
ZCP4_RS04630	COG0436	Aminotransferase
ZCP4_RS04650	COG2894	cell division
ZCP4_RS04655	COG0352	thiamine-phosphate diphosphorylase activity
ZCP4_RS04660	COG3108	Peptidase M15
ZCP4_RS04670	COG0483	inositol monophosphate 1-phosphatase activity
ZCP4_RS04675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZCP4_RS04680	COG0626	cystathionine gamma-synthase activity
ZCP4_RS04685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZCP4_RS04695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZCP4_RS04700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZCP4_RS04705	COG0196	riboflavin kinase activity
ZCP4_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
ZCP4_RS04735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZCP4_RS04745	COG1473	amidohydrolase
ZCP4_RS04755	COG1028	Short-chain dehydrogenase reductase Sdr
ZCP4_RS04775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZCP4_RS04790	COG1570	exodeoxyribonuclease VII activity
ZCP4_RS04795	COG0151	Belongs to the GarS family
ZCP4_RS04805	COG1253	flavin adenine dinucleotide binding
ZCP4_RS04810	COG0590	tRNA wobble adenosine to inosine editing
ZCP4_RS04815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZCP4_RS04820	COG2814	Major facilitator Superfamily
ZCP4_RS04825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZCP4_RS04830	COG2733	membrane
ZCP4_RS04855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZCP4_RS04865	COG1278	Cold shock
ZCP4_RS04885	COG1137	ATPase activity
ZCP4_RS04890	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZCP4_RS04895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZCP4_RS04900	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZCP4_RS04950	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZCP4_RS04955	COG4133	protoheme IX ABC transporter activity
ZCP4_RS04970	COG0277	FAD linked oxidase domain protein
ZCP4_RS04975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZCP4_RS05005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZCP4_RS05010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZCP4_RS05015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZCP4_RS05020	COG0776	regulation of translation
ZCP4_RS05030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZCP4_RS05035	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZCP4_RS05040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZCP4_RS05045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZCP4_RS05050	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZCP4_RS05060	COG0489	protein tyrosine kinase activity
ZCP4_RS05065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZCP4_RS05080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZCP4_RS05090	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZCP4_RS05095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZCP4_RS05105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZCP4_RS05105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZCP4_RS05110	COG4221	oxidoreductase activity
ZCP4_RS05115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZCP4_RS05120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZCP4_RS05120	COG2813	Specifically methylates the guanine in position
ZCP4_RS05140	COG1329	Transcriptional regulator
ZCP4_RS05145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ZCP4_RS05150	COG4581	dead DEAH box helicase
ZCP4_RS05155	COG0739	heme binding
ZCP4_RS05165	COG0534	Mate efflux family protein
ZCP4_RS05175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZCP4_RS05180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZCP4_RS05190	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZCP4_RS05195	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZCP4_RS05210	COG0789	Transcriptional regulator
ZCP4_RS05215	COG0840	transmembrane signaling receptor activity
ZCP4_RS05220	COG0512	Glutamine amidotransferase of anthranilate synthase
ZCP4_RS05225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZCP4_RS05230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZCP4_RS05240	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZCP4_RS05255	COG1530	ribonuclease E activity
ZCP4_RS05275	COG1760	l-serine dehydratase
ZCP4_RS05290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ZCP4_RS05295	COG0215	cysteine-tRNA ligase activity
ZCP4_RS05305	COG0488	(ABC) transporter
ZCP4_RS05310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZCP4_RS05315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZCP4_RS05320	COG1830	Aldolase
ZCP4_RS05330	COG0126	phosphoglycerate kinase activity
ZCP4_RS05335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZCP4_RS05360	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZCP4_RS05370	COG0584	glycerophosphoryl diester phosphodiesterase
ZCP4_RS05375	COG2885	chlorophyll binding
ZCP4_RS05380	COG0823	Involved in the tonB-independent uptake of proteins
ZCP4_RS05390	COG0848	biopolymer transport protein
ZCP4_RS05395	COG0811	peptide transport
ZCP4_RS05400	COG0824	Thioesterase
ZCP4_RS05405	COG2255	four-way junction helicase activity
ZCP4_RS05410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZCP4_RS05420	COG0632	four-way junction helicase activity
ZCP4_RS05425	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZCP4_RS05430	COG0217	transcriptional regulatory protein
ZCP4_RS05435	COG3750	Belongs to the UPF0335 family
ZCP4_RS05440	COG0469	pyruvate kinase activity
ZCP4_RS05450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZCP4_RS05470	COG1131	(ABC) transporter
ZCP4_RS05485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZCP4_RS05540	COG0671	phosphoesterase, PA-phosphatase related
ZCP4_RS05560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZCP4_RS05575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZCP4_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
ZCP4_RS05595	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ZCP4_RS05600	COG1151	hydroxylamine reductase activity
ZCP4_RS05605	COG1959	2 iron, 2 sulfur cluster binding
ZCP4_RS05610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZCP4_RS05615	COG0512	Glutamine amidotransferase of anthranilate synthase
ZCP4_RS05615	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZCP4_RS05620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZCP4_RS05630	COG0488	(ABC) transporter
ZCP4_RS05655	COG0066	3-isopropylmalate dehydratase activity
ZCP4_RS05660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZCP4_RS05665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ZCP4_RS05695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZCP4_RS05705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZCP4_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
ZCP4_RS05735	COG0840	transmembrane signaling receptor activity
ZCP4_RS05745	COG2198	Histidine kinase
ZCP4_RS05745	COG0643	Histidine kinase
ZCP4_RS05750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZCP4_RS05755	COG2201	protein-glutamate methylesterase activity
ZCP4_RS05760	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ZCP4_RS05765	COG0745	RESPONSE REGULATOR receiver
ZCP4_RS05770	COG0835	chemotaxis
ZCP4_RS05775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZCP4_RS05780	COG1702	phosphate starvation-inducible protein PhoH
ZCP4_RS05785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZCP4_RS05800	COG2999	glutathione oxidoreductase activity
ZCP4_RS05840	COG1929	Belongs to the glycerate kinase type-1 family
ZCP4_RS05855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZCP4_RS05860	COG0730	response to heat
ZCP4_RS05865	COG1846	Transcriptional regulator
ZCP4_RS05870	COG0596	Alpha beta hydrolase
ZCP4_RS05875	COG2807	transmembrane transport
ZCP4_RS05895	COG0424	maF-like protein
ZCP4_RS05905	COG0237	dephospho-CoA kinase activity
ZCP4_RS05910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZCP4_RS05915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ZCP4_RS05920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZCP4_RS05935	COG2983	Belongs to the UPF0260 family
ZCP4_RS05950	COG1715	Restriction endonuclease
ZCP4_RS05955	COG0138	bifunctional purine biosynthesis protein purh
ZCP4_RS05975	COG0247	lactate metabolic process
ZCP4_RS05980	COG1139	Iron-sulfur cluster binding protein
ZCP4_RS05995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZCP4_RS06005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZCP4_RS06010	COG1420	regulation of RNA biosynthetic process
ZCP4_RS06015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZCP4_RS06020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZCP4_RS06025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZCP4_RS06040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ZCP4_RS06045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZCP4_RS06050	COG0175	sulfate reduction
ZCP4_RS06055	COG1648	precorrin-2 dehydrogenase activity
ZCP4_RS06055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZCP4_RS06060	COG0175	sulfate reduction
ZCP4_RS06075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZCP4_RS06085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZCP4_RS06095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ZCP4_RS06110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZCP4_RS06115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZCP4_RS06120	COG4771	TonB-dependent receptor
ZCP4_RS06125	COG0667	Aldo Keto reductase
ZCP4_RS06130	COG3386	PFAM SMP-30 Gluconolaconase
ZCP4_RS06135	COG0445	tRNA wobble uridine modification
ZCP4_RS06140	COG0357	Ribosomal RNA small subunit methyltransferase G
ZCP4_RS06155	COG0477	Major facilitator Superfamily
ZCP4_RS06165	COG2423	ornithine cyclodeaminase activity
ZCP4_RS06170	COG0583	DNA-binding transcription factor activity
ZCP4_RS06180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ZCP4_RS06185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ZCP4_RS06205	COG0658	competence protein
ZCP4_RS06205	COG2333	competence protein COMEC
ZCP4_RS06210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZCP4_RS06215	COG0372	Belongs to the citrate synthase family
ZCP4_RS06220	COG5002	protein histidine kinase activity
ZCP4_RS06245	COG0438	transferase activity, transferring glycosyl groups
ZCP4_RS06245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZCP4_RS06250	COG0497	DNA recombination
ZCP4_RS06260	COG0459	protein refolding
ZCP4_RS06265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZCP4_RS06270	COG0616	signal peptide processing
ZCP4_RS06275	COG0826	peptidase U32
ZCP4_RS06285	COG1368	sulfuric ester hydrolase activity
ZCP4_RS06310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZCP4_RS06315	COG0156	8-amino-7-oxononanoate synthase activity
ZCP4_RS06325	COG4106	trans-aconitate 2-methyltransferase activity
ZCP4_RS06325	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZCP4_RS06335	COG0189	ligase activity
ZCP4_RS06340	COG0012	GTP binding
ZCP4_RS06345	COG0193	aminoacyl-tRNA hydrolase activity
ZCP4_RS06350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZCP4_RS06365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZCP4_RS06370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZCP4_RS06375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZCP4_RS06380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZCP4_RS06385	COG0181	hydroxymethylbilane synthase activity
ZCP4_RS06400	COG0416	fatty acid biosynthetic process
ZCP4_RS06405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZCP4_RS06415	COG1862	Preprotein translocase
ZCP4_RS06420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZCP4_RS06430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ZCP4_RS06450	COG0612	Peptidase, M16
ZCP4_RS06465	COG1335	isochorismatase
ZCP4_RS06470	COG3180	Ammonia monooxygenase
ZCP4_RS06475	COG1902	pentaerythritol trinitrate reductase activity
ZCP4_RS06480	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZCP4_RS06485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZCP4_RS06490	COG3180	Ammonia monooxygenase
ZCP4_RS06505	COG0113	porphobilinogen synthase activity
ZCP4_RS06510	COG0525	valine-tRNA ligase activity
ZCP4_RS06535	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ZCP4_RS06545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ZCP4_RS06565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZCP4_RS06630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZCP4_RS06635	COG0716	FMN binding
ZCP4_RS06655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZCP4_RS06660	COG1120	ATPase activity
ZCP4_RS06665	COG2824	Alkylphosphonate utilization operon protein PhnA
ZCP4_RS06670	COG0673	inositol 2-dehydrogenase activity
ZCP4_RS06690	COG3585	molybdate ion transport
ZCP4_RS06705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZCP4_RS06710	COG1104	cysteine desulfurase activity
ZCP4_RS06740	COG1433	Dinitrogenase iron-molybdenum cofactor
ZCP4_RS06745	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZCP4_RS06750	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZCP4_RS06755	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZCP4_RS06760	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZCP4_RS06765	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ZCP4_RS06770	COG4774	siderophore transport
ZCP4_RS06780	COG5554	nitrogen fixation
ZCP4_RS06790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZCP4_RS06795	COG0535	radical SAM domain protein
ZCP4_RS06800	COG3604	Transcriptional regulator
ZCP4_RS06810	COG4657	Part of a membrane complex involved in electron transport
ZCP4_RS06820	COG4656	Part of a membrane complex involved in electron transport
ZCP4_RS06825	COG4658	electron transport chain
ZCP4_RS06850	COG0110	maltose O-acetyltransferase activity
ZCP4_RS06855	COG0546	phosphoglycolate phosphatase activity
ZCP4_RS06860	COG0531	amino acid
ZCP4_RS06865	COG0776	regulation of translation
ZCP4_RS06875	COG0539	negative regulation of cytoplasmic translation
ZCP4_RS06880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZCP4_RS06885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZCP4_RS06900	COG0583	DNA-binding transcription factor activity
ZCP4_RS06905	COG0129	dihydroxy-acid dehydratase activity
ZCP4_RS06915	COG1132	(ABC) transporter
ZCP4_RS06935	COG0668	transmembrane transport
ZCP4_RS06975	COG0656	L-ascorbic acid biosynthetic process
ZCP4_RS06980	COG0604	alcohol dehydrogenase
ZCP4_RS06980	COG3321	synthase
ZCP4_RS06985	COG1979	alcohol dehydrogenase
ZCP4_RS06990	COG0165	Argininosuccinate lyase
ZCP4_RS07000	COG0019	diaminopimelate decarboxylase activity
ZCP4_RS07005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ZCP4_RS07015	COG2989	Protein conserved in bacteria
ZCP4_RS07025	COG0792	nuclease activity
ZCP4_RS07030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZCP4_RS07040	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZCP4_RS07045	COG3265	gluconokinase activity
ZCP4_RS07050	COG2610	gluconate transmembrane transporter activity
ZCP4_RS07055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZCP4_RS07060	COG1012	belongs to the aldehyde dehydrogenase family
ZCP4_RS07085	COG2853	Lipoprotein
ZCP4_RS07105	COG1410	methionine synthase
ZCP4_RS07105	COG0646	methionine synthase
ZCP4_RS07115	COG0481	GTPase activity
ZCP4_RS07125	COG3275	phosphorelay sensor kinase activity
ZCP4_RS07130	COG3279	Response regulator of the LytR AlgR family
ZCP4_RS07145	COG0583	DNA-binding transcription factor activity
ZCP4_RS07155	COG1045	serine acetyltransferase
ZCP4_RS07170	COG0436	Aminotransferase
ZCP4_RS07175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ZCP4_RS07180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZCP4_RS07195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ZCP4_RS07205	COG1758	RNA polymerase activity
ZCP4_RS07210	COG1940	carbohydrate kinase activity
ZCP4_RS07240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZCP4_RS07250	COG0628	permease
ZCP4_RS07255	COG0681	Belongs to the peptidase S26 family
ZCP4_RS07260	COG0736	holo-[acyl-carrier-protein] synthase activity
ZCP4_RS07265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZCP4_RS07270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZCP4_RS07285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZCP4_RS07290	COG1674	ftsk spoiiie
ZCP4_RS07295	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ZCP4_RS07305	COG0708	Exodeoxyribonuclease III
ZCP4_RS07315	COG1733	regulation of RNA biosynthetic process
ZCP4_RS07335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZCP4_RS07340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZCP4_RS07345	COG1295	ribonuclease BN
ZCP4_RS07350	COG0484	heat shock protein binding
ZCP4_RS07355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZCP4_RS07360	COG0354	folic acid binding
ZCP4_RS07365	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZCP4_RS07375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZCP4_RS07385	COG0252	asparaginase activity
ZCP4_RS07395	COG2985	domain, Protein
ZCP4_RS07410	COG0077	Prephenate dehydratase
ZCP4_RS07415	COG1194	a g-specific adenine glycosylase
ZCP4_RS07430	COG0656	L-ascorbic acid biosynthetic process
ZCP4_RS07450	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ZCP4_RS07460	COG0793	Belongs to the peptidase S41A family
ZCP4_RS07470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZCP4_RS07475	COG0799	negative regulation of ribosome biogenesis
ZCP4_RS07480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZCP4_RS07485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZCP4_RS07500	COG0037	tRNA processing
ZCP4_RS07520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ZCP4_RS07535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ZCP4_RS07545	COG3386	PFAM SMP-30 Gluconolaconase
ZCP4_RS07550	COG1573	uracil-dna glycosylase
ZCP4_RS07565	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZCP4_RS07575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZCP4_RS07580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ZCP4_RS07590	COG0180	Tryptophanyl-tRNA synthetase
ZCP4_RS07595	COG0728	peptidoglycan biosynthetic process
ZCP4_RS07600	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ZCP4_RS07615	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ZCP4_RS07630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZCP4_RS07635	COG4774	siderophore transport
ZCP4_RS07655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZCP4_RS07660	COG0706	membrane insertase activity
ZCP4_RS07665	COG0594	ribonuclease P activity
ZCP4_RS07675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZCP4_RS07690	COG0505	Belongs to the CarA family
ZCP4_RS07700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZCP4_RS07730	COG0148	phosphopyruvate hydratase activity
ZCP4_RS07740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZCP4_RS07745	COG0022	dehydrogenase e1 component
ZCP4_RS07745	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZCP4_RS07755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZCP4_RS07755	COG3453	Protein conserved in bacteria
ZCP4_RS07765	COG0328	RNA-DNA hybrid ribonuclease activity
ZCP4_RS07770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZCP4_RS07780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZCP4_RS07785	COG1454	alcohol dehydrogenase
ZCP4_RS07800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZCP4_RS07805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZCP4_RS07810	COG1127	ABC transporter
ZCP4_RS07815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZCP4_RS07820	COG0730	response to heat
ZCP4_RS07825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZCP4_RS07840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZCP4_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
ZCP4_RS07905	COG4221	oxidoreductase activity
ZCP4_RS07925	COG1294	oxidase, subunit
ZCP4_RS07930	COG1271	oxidase subunit
ZCP4_RS07945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZCP4_RS07960	COG1742	UPF0060 membrane protein
ZCP4_RS07980	COG1051	belongs to the nudix hydrolase family
ZCP4_RS07985	COG4221	oxidoreductase activity
ZCP4_RS07990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZCP4_RS08005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZCP4_RS08010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZCP4_RS08015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZCP4_RS08020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZCP4_RS08030	COG1657	PFAM Prenyltransferase squalene oxidase
ZCP4_RS08055	COG0629	single-stranded DNA binding
ZCP4_RS08085	COG0047	phosphoribosylformylglycinamidine synthase activity
ZCP4_RS08090	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZCP4_RS08095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZCP4_RS08095	COG0517	IMP dehydrogenase activity
ZCP4_RS08100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZCP4_RS08115	COG1538	Outer membrane efflux protein
ZCP4_RS08140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZCP4_RS08150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZCP4_RS08155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZCP4_RS08160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZCP4_RS08160	COG0072	phenylalanine-tRNA ligase activity
ZCP4_RS08165	COG5265	(ABC) transporter
ZCP4_RS08175	COG2890	protein-(glutamine-N5) methyltransferase activity
ZCP4_RS08180	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZCP4_RS08185	COG0124	histidyl-tRNA synthetase
ZCP4_RS08190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZCP4_RS08210	COG0131	Imidazoleglycerol-phosphate dehydratase
ZCP4_RS08215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZCP4_RS08220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZCP4_RS08225	COG0107	imidazoleglycerol-phosphate synthase activity
ZCP4_RS08230	COG0140	phosphoribosyl-ATP diphosphatase activity
ZCP4_RS08240	COG0531	amino acid
ZCP4_RS08245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZCP4_RS08250	COG2096	Adenosyltransferase
ZCP4_RS08255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZCP4_RS08275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZCP4_RS08280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZCP4_RS08285	COG2199	diguanylate cyclase activity
ZCP4_RS08285	COG2200	EAL domain
ZCP4_RS08300	COG0210	DNA helicase
ZCP4_RS08315	COG0045	succinate-CoA ligase (ADP-forming) activity
ZCP4_RS08330	COG0363	glucosamine-6-phosphate deaminase activity
ZCP4_RS08350	COG1217	gtp-binding protein TYPA
ZCP4_RS08365	COG0814	amino acid
ZCP4_RS08390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ZCP4_RS08395	COG2814	Major facilitator Superfamily
ZCP4_RS08405	COG0415	Belongs to the DNA photolyase family
ZCP4_RS08410	COG0246	Mannitol dehydrogenase
ZCP4_RS08430	COG0752	glycyl-tRNA synthetase alpha subunit
ZCP4_RS08440	COG2244	polysaccharide biosynthetic process
ZCP4_RS08460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZCP4_RS08480	COG0495	leucyl-tRNA aminoacylation
ZCP4_RS08515	COG1597	lipid kinase activity
ZCP4_RS08520	COG2003	Belongs to the UPF0758 family
ZCP4_RS08525	COG0352	thiamine-phosphate diphosphorylase activity
ZCP4_RS08535	COG0612	Peptidase, M16
ZCP4_RS08540	COG0612	Peptidase, M16
ZCP4_RS08545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZCP4_RS08550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZCP4_RS08555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ZCP4_RS08565	COG0513	Belongs to the DEAD box helicase family
ZCP4_RS08580	COG1214	PFAM Peptidase M22, glycoprotease
ZCP4_RS08590	COG4957	zinc ion binding
ZCP4_RS08600	COG2193	ferroxidase activity
ZCP4_RS08620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZCP4_RS08625	COG0596	Alpha beta hydrolase
ZCP4_RS08630	COG0784	Response regulator, receiver
ZCP4_RS08640	COG0739	heme binding
ZCP4_RS08645	COG0316	Belongs to the HesB IscA family
ZCP4_RS08650	COG0708	Exodeoxyribonuclease III
ZCP4_RS08710	COG0405	Gamma-glutamyltransferase
ZCP4_RS08730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZCP4_RS08735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZCP4_RS08765	COG0571	ribonuclease III activity
ZCP4_RS08775	COG0300	oxidoreductase activity
ZCP4_RS08795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZCP4_RS08805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZCP4_RS08825	COG3961	Belongs to the TPP enzyme family
ZCP4_RS08830	COG0268	Binds directly to 16S ribosomal RNA
ZCP4_RS09005	COG0668	transmembrane transport
ZCP4_RS09050	COG0745	RESPONSE REGULATOR receiver
ZCP4_RS09300	COG0308	aminopeptidase N
ZCP4_RS09315	COG2321	neutral zinc metallopeptidase
ZCP4_RS09660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZCP4_RS09670	COG0642	Histidine kinase