locus-tag	class	description
ZYMOP_RS00005	COG0268	Binds directly to 16S ribosomal RNA
ZYMOP_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ZYMOP_RS00015	COG0488	(ABC) transporter
ZYMOP_RS00020	COG2885	chlorophyll binding
ZYMOP_RS00020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ZYMOP_RS00025	COG4702	Belongs to the UPF0303 family
ZYMOP_RS00030	COG0670	Belongs to the BI1 family
ZYMOP_RS00040	COG1058	Belongs to the CinA family
ZYMOP_RS00040	COG1546	Belongs to the CinA family
ZYMOP_RS00045	COG0024	Methionine aminopeptidase
ZYMOP_RS00060	COG0308	aminopeptidase N
ZYMOP_RS00070	COG2321	neutral zinc metallopeptidase
ZYMOP_RS00075	COG0668	transmembrane transport
ZYMOP_RS00080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZYMOP_RS00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZYMOP_RS00095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ZYMOP_RS00095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZYMOP_RS00100	COG1660	Displays ATPase and GTPase activities
ZYMOP_RS00105	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ZYMOP_RS00110	COG0642	Histidine kinase
ZYMOP_RS00115	COG0745	RESPONSE REGULATOR receiver
ZYMOP_RS00125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ZYMOP_RS00125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZYMOP_RS00135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ZYMOP_RS00140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ZYMOP_RS00150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ZYMOP_RS00155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZYMOP_RS00165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ZYMOP_RS00165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ZYMOP_RS00170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ZYMOP_RS00185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ZYMOP_RS00190	COG0321	lipoyl(octanoyl) transferase activity
ZYMOP_RS00200	COG0602	queuosine metabolic process
ZYMOP_RS00205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ZYMOP_RS00215	COG2261	transglycosylase associated protein
ZYMOP_RS00240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ZYMOP_RS00245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ZYMOP_RS00250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ZYMOP_RS00260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ZYMOP_RS00270	COG1012	belongs to the aldehyde dehydrogenase family
ZYMOP_RS00275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZYMOP_RS00275	COG1648	precorrin-2 dehydrogenase activity
ZYMOP_RS00295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ZYMOP_RS00295	COG0519	Catalyzes the synthesis of GMP from XMP
ZYMOP_RS00300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZYMOP_RS00305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
ZYMOP_RS00310	COG1138	Cytochrome C-type biogenesis protein
ZYMOP_RS00315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ZYMOP_RS00320	COG3088	subunit of a heme lyase
ZYMOP_RS00340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ZYMOP_RS00350	COG2866	Carboxypeptidase
ZYMOP_RS00355	COG0588	phosphoglycerate mutase activity
ZYMOP_RS00360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZYMOP_RS00370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZYMOP_RS00375	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ZYMOP_RS00375	COG0662	Cupin 2, conserved barrel domain protein
ZYMOP_RS00395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ZYMOP_RS00400	COG0302	gtp cyclohydrolase
ZYMOP_RS00405	COG4948	Mandelate Racemase Muconate Lactonizing
ZYMOP_RS00410	COG0359	binds to the 23S rRNA
ZYMOP_RS00415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ZYMOP_RS00420	COG0360	Binds together with S18 to 16S ribosomal RNA
ZYMOP_RS00425	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ZYMOP_RS00440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZYMOP_RS00445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ZYMOP_RS00450	COG0805	protein transport
ZYMOP_RS00470	COG0513	Belongs to the DEAD box helicase family
ZYMOP_RS00480	COG0166	Belongs to the GPI family
ZYMOP_RS00495	COG3158	transport of potassium into the cell
ZYMOP_RS00520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ZYMOP_RS00525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZYMOP_RS00530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ZYMOP_RS00540	COG0156	8-amino-7-oxononanoate synthase activity
ZYMOP_RS00545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ZYMOP_RS00550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ZYMOP_RS00555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZYMOP_RS00555	COG0758	DNA mediated transformation
ZYMOP_RS00560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ZYMOP_RS00560	COG1754	DNA topoisomerase type I activity
ZYMOP_RS00565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ZYMOP_RS00570	COG0756	dUTP diphosphatase activity
ZYMOP_RS00575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ZYMOP_RS00585	COG2226	methyltransferase
ZYMOP_RS00595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ZYMOP_RS00620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ZYMOP_RS00630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ZYMOP_RS00630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ZYMOP_RS00635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ZYMOP_RS00640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ZYMOP_RS00650	COG2205	protein histidine kinase activity
ZYMOP_RS00665	COG3724	N-succinylarginine dihydrolase activity
ZYMOP_RS00670	COG1472	Belongs to the glycosyl hydrolase 3 family
ZYMOP_RS00680	COG2971	BadF BadG BcrA BcrD
ZYMOP_RS00690	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ZYMOP_RS00695	COG1040	competence protein
ZYMOP_RS00700	COG0745	RESPONSE REGULATOR receiver
ZYMOP_RS00705	COG0704	Plays a role in the regulation of phosphate uptake
ZYMOP_RS00715	COG0688	phosphatidylethanolamine metabolic process
ZYMOP_RS00725	COG0052	Belongs to the universal ribosomal protein uS2 family
ZYMOP_RS00730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ZYMOP_RS00735	COG0528	UMP kinase activity
ZYMOP_RS00740	COG0233	cytoplasmic translational termination
ZYMOP_RS00745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ZYMOP_RS00750	COG0575	Belongs to the CDS family
ZYMOP_RS00755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ZYMOP_RS00760	COG0750	zinc metalloprotease
ZYMOP_RS00765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZYMOP_RS00775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ZYMOP_RS00780	COG0254	rRNA binding
ZYMOP_RS00790	COG0492	ferredoxin-NADP+ reductase activity
ZYMOP_RS00795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ZYMOP_RS00800	COG0440	acetolactate synthase activity
ZYMOP_RS00805	COG0028	Belongs to the TPP enzyme family
ZYMOP_RS00810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ZYMOP_RS00815	COG3830	Belongs to the UPF0237 family
ZYMOP_RS00815	COG0560	Phosphoserine phosphatase
ZYMOP_RS00820	COG1858	cytochrome C peroxidase
ZYMOP_RS00825	COG0312	modulator of DNA gyrase
ZYMOP_RS00835	COG0288	reversible hydration of carbon dioxide
ZYMOP_RS00840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ZYMOP_RS00845	COG2867	negative regulation of translational initiation
ZYMOP_RS00860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ZYMOP_RS00860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ZYMOP_RS00875	COG5000	phosphorelay sensor kinase activity
ZYMOP_RS00880	COG2204	response regulator
ZYMOP_RS00890	COG0776	regulation of translation
ZYMOP_RS00915	COG1968	undecaprenyl-diphosphatase activity
ZYMOP_RS00925	COG1573	uracil-dna glycosylase
ZYMOP_RS00930	COG1252	NADH dehydrogenase
ZYMOP_RS00935	COG2917	probably involved in intracellular septation
ZYMOP_RS00940	COG2807	transmembrane transport
ZYMOP_RS00950	COG1522	sequence-specific DNA binding
ZYMOP_RS00965	COG2205	protein histidine kinase activity
ZYMOP_RS00970	COG0802	atpase or kinase
ZYMOP_RS00975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ZYMOP_RS00995	COG0557	exoribonuclease II activity
ZYMOP_RS01000	COG3956	TIGRFAM MazG family protein
ZYMOP_RS01005	COG0321	lipoyl(octanoyl) transferase activity
ZYMOP_RS01005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ZYMOP_RS01010	COG0084	hydrolase, TatD family'
ZYMOP_RS01020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ZYMOP_RS01025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZYMOP_RS01030	COG1686	Belongs to the peptidase S11 family
ZYMOP_RS01040	COG2951	lytic endotransglycosylase activity
ZYMOP_RS01045	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ZYMOP_RS01055	COG1215	transferase activity, transferring glycosyl groups
ZYMOP_RS01070	COG0335	large ribosomal subunit rRNA binding
ZYMOP_RS01075	COG0336	Belongs to the RNA methyltransferase TrmD family
ZYMOP_RS01080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ZYMOP_RS01085	COG0228	four-way junction DNA binding
ZYMOP_RS01090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ZYMOP_RS01095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ZYMOP_RS01100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZYMOP_RS01105	COG0552	protein localization to endoplasmic reticulum
ZYMOP_RS01120	COG2166	iron-sulfur cluster assembly
ZYMOP_RS01125	COG2223	nitrite transmembrane transporter activity
ZYMOP_RS01145	COG1842	Phage shock protein A
ZYMOP_RS01155	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ZYMOP_RS01160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ZYMOP_RS01175	COG0617	tRNA 3'-terminal CCA addition
ZYMOP_RS01180	COG5001	Diguanylate cyclase
ZYMOP_RS01185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZYMOP_RS01190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ZYMOP_RS01195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ZYMOP_RS01200	COG0581	inorganic phosphate transmembrane transporter activity
ZYMOP_RS01205	COG0573	inorganic phosphate transmembrane transporter activity
ZYMOP_RS01210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ZYMOP_RS01220	COG1970	mechanosensitive ion channel activity
ZYMOP_RS01230	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ZYMOP_RS01235	COG0494	nUDIX hydrolase
ZYMOP_RS01245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ZYMOP_RS01245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZYMOP_RS01260	COG0137	argininosuccinate synthase activity
ZYMOP_RS01270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ZYMOP_RS01275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ZYMOP_RS01305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ZYMOP_RS01310	COG1104	cysteine desulfurase activity
ZYMOP_RS01315	COG2945	thiolester hydrolase activity
ZYMOP_RS01320	COG0019	diaminopimelate decarboxylase activity
ZYMOP_RS01325	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ZYMOP_RS01350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ZYMOP_RS01355	COG0424	maF-like protein
ZYMOP_RS01365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ZYMOP_RS01385	COG0277	FAD linked oxidase domain protein
ZYMOP_RS01390	COG3781	membrane
ZYMOP_RS01395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ZYMOP_RS01405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ZYMOP_RS01410	COG0351	phosphomethylpyrimidine kinase
ZYMOP_RS01410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ZYMOP_RS01410	COG0352	thiamine-phosphate diphosphorylase activity
ZYMOP_RS01415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ZYMOP_RS01420	COG3104	oligopeptide transport
ZYMOP_RS01430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ZYMOP_RS01435	COG0009	L-threonylcarbamoyladenylate synthase
ZYMOP_RS01440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ZYMOP_RS01445	COG0800	Aldolase
ZYMOP_RS01450	COG0668	transmembrane transport
ZYMOP_RS01475	COG0071	Belongs to the small heat shock protein (HSP20) family
ZYMOP_RS01490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ZYMOP_RS01495	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ZYMOP_RS01510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ZYMOP_RS01515	COG4172	Belongs to the ABC transporter superfamily
ZYMOP_RS01525	COG4206	TonB-dependent receptor
ZYMOP_RS01535	COG0667	Aldo Keto reductase
ZYMOP_RS01565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZYMOP_RS01575	COG2252	PERMEase
ZYMOP_RS01585	COG2814	Major facilitator Superfamily
ZYMOP_RS01590	COG1566	PFAM secretion protein HlyD family protein
ZYMOP_RS01600	COG1309	transcriptional regulator
ZYMOP_RS01605	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ZYMOP_RS01625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ZYMOP_RS01630	COG0723	plastoquinol--plastocyanin reductase activity
ZYMOP_RS01635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ZYMOP_RS01640	COG0408	coproporphyrinogen oxidase activity
ZYMOP_RS01650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ZYMOP_RS01655	COG0740	serine-type endopeptidase activity
ZYMOP_RS01665	COG0544	peptidyl-prolyl cis-trans isomerase activity
ZYMOP_RS01685	COG1621	beta-fructofuranosidase activity
ZYMOP_RS01700	COG1846	Transcriptional regulator
ZYMOP_RS01705	COG0402	S-adenosylhomocysteine deaminase activity
ZYMOP_RS01710	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
ZYMOP_RS01715	COG1448	Aminotransferase
ZYMOP_RS01750	COG3191	aminopeptidase activity
ZYMOP_RS01755	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ZYMOP_RS01770	COG0653	protein targeting
ZYMOP_RS01775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ZYMOP_RS01810	COG2608	mercury ion transmembrane transporter activity
ZYMOP_RS01815	COG2217	Heavy metal translocating P-type atpase
ZYMOP_RS01820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ZYMOP_RS01825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZYMOP_RS01865	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
ZYMOP_RS01875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZYMOP_RS01890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZYMOP_RS01890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ZYMOP_RS01940	COG1280	lysine exporter protein (LysE YggA)
ZYMOP_RS01955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ZYMOP_RS01975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ZYMOP_RS01980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ZYMOP_RS01985	COG0840	transmembrane signaling receptor activity
ZYMOP_RS01990	COG2198	Histidine kinase
ZYMOP_RS01990	COG0643	Histidine kinase
ZYMOP_RS01995	COG2201	protein-glutamate methylesterase activity
ZYMOP_RS02010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ZYMOP_RS02015	COG0535	radical SAM domain protein
ZYMOP_RS02025	COG1657	PFAM Prenyltransferase squalene oxidase
ZYMOP_RS02030	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ZYMOP_RS02035	COG1562	ergosterol biosynthetic process
ZYMOP_RS02040	COG1562	ergosterol biosynthetic process
ZYMOP_RS02050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ZYMOP_RS02060	COG0305	Participates in initiation and elongation during chromosome replication
ZYMOP_RS02065	COG0295	cytidine deaminase activity
ZYMOP_RS02070	COG0717	Belongs to the dCTP deaminase family
ZYMOP_RS02075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ZYMOP_RS02105	COG1722	exodeoxyribonuclease VII activity
ZYMOP_RS02110	COG0142	geranyltranstransferase activity
ZYMOP_RS02115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ZYMOP_RS02125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ZYMOP_RS02130	COG0259	pyridoxamine-phosphate oxidase activity
ZYMOP_RS02140	COG0655	NAD(P)H dehydrogenase (quinone) activity
ZYMOP_RS02160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ZYMOP_RS02170	COG0018	arginyl-trna synthetase
ZYMOP_RS02175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ZYMOP_RS02180	COG0038	chloride channel
ZYMOP_RS02190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ZYMOP_RS02195	COG0849	cell division
ZYMOP_RS02200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ZYMOP_RS02205	COG1181	Belongs to the D-alanine--D-alanine ligase family
ZYMOP_RS02210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ZYMOP_RS02215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ZYMOP_RS02220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZYMOP_RS02230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ZYMOP_RS02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ZYMOP_RS02245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ZYMOP_RS02260	COG0275	rRNA processing
ZYMOP_RS02280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZYMOP_RS02285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ZYMOP_RS02290	COG0720	synthase
ZYMOP_RS02305	COG1322	Protein conserved in bacteria
ZYMOP_RS02310	COG0242	peptide deformylase activity
ZYMOP_RS02315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ZYMOP_RS02320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ZYMOP_RS02325	COG0101	tRNA pseudouridine synthase activity
ZYMOP_RS02330	COG1872	DUF167
ZYMOP_RS02335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZYMOP_RS02340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ZYMOP_RS02360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZYMOP_RS02365	COG0540	Belongs to the ATCase OTCase family
ZYMOP_RS02385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ZYMOP_RS02390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZYMOP_RS02395	COG0154	amidase activity
ZYMOP_RS02400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ZYMOP_RS02405	COG0583	DNA-binding transcription factor activity
ZYMOP_RS02410	COG1538	Outer membrane efflux protein
ZYMOP_RS02425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZYMOP_RS02440	COG0583	DNA-binding transcription factor activity
ZYMOP_RS02450	COG2239	Acts as a magnesium transporter
ZYMOP_RS02455	COG0482	sulfurtransferase activity
ZYMOP_RS02470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ZYMOP_RS02475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ZYMOP_RS02495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZYMOP_RS02520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ZYMOP_RS02535	COG0564	pseudouridine synthase activity
ZYMOP_RS02540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZYMOP_RS02575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ZYMOP_RS02590	COG2022	thiamine diphosphate biosynthetic process
ZYMOP_RS02595	COG2104	thiamine diphosphate biosynthetic process
ZYMOP_RS02595	COG2022	thiamine diphosphate biosynthetic process
ZYMOP_RS02600	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ZYMOP_RS02605	COG0511	ligase activity, forming carbon-carbon bonds
ZYMOP_RS02610	COG0439	Biotin carboxylase
ZYMOP_RS02620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ZYMOP_RS02625	COG0085	RNA polymerase activity
ZYMOP_RS02630	COG0222	ribosome binding
ZYMOP_RS02635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ZYMOP_RS02640	COG0081	regulation of translation
ZYMOP_RS02645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ZYMOP_RS02655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ZYMOP_RS02665	COG3590	peptidase
ZYMOP_RS02670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ZYMOP_RS02675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ZYMOP_RS02680	COG0741	lytic transglycosylase activity
ZYMOP_RS02695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ZYMOP_RS02700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ZYMOP_RS02710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ZYMOP_RS02725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ZYMOP_RS02730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ZYMOP_RS02735	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ZYMOP_RS02740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ZYMOP_RS02750	COG0318	PFAM AMP-dependent synthetase and ligase
ZYMOP_RS02790	COG1764	response to oxidative stress
ZYMOP_RS02795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ZYMOP_RS02800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ZYMOP_RS02805	COG0673	inositol 2-dehydrogenase activity
ZYMOP_RS02810	COG0679	Auxin Efflux Carrier
ZYMOP_RS02820	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ZYMOP_RS02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZYMOP_RS02855	COG0473	3-isopropylmalate dehydrogenase activity
ZYMOP_RS02865	COG0583	DNA-binding transcription factor activity
ZYMOP_RS02875	COG1381	Involved in DNA repair and RecF pathway recombination
ZYMOP_RS02880	COG0322	excinuclease ABC activity
ZYMOP_RS02885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZYMOP_RS02890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ZYMOP_RS02900	COG0356	it plays a direct role in the translocation of protons across the membrane
ZYMOP_RS02925	COG2003	Belongs to the UPF0758 family
ZYMOP_RS02930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ZYMOP_RS02935	COG0484	heat shock protein binding
ZYMOP_RS02940	COG0443	Heat shock 70 kDa protein
ZYMOP_RS02955	COG3138	arginine N-succinyltransferase
ZYMOP_RS02965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ZYMOP_RS02970	COG0726	polysaccharide deacetylase
ZYMOP_RS02975	COG0628	permease
ZYMOP_RS02985	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ZYMOP_RS02985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ZYMOP_RS02990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ZYMOP_RS02995	COG1684	flagellar biosynthetic protein fliR
ZYMOP_RS03000	COG1987	bacterial-type flagellum assembly
ZYMOP_RS03050	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ZYMOP_RS03060	COG1677	Flagellar hook-basal body complex protein FliE
ZYMOP_RS03120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ZYMOP_RS03130	COG1558	bacterial-type flagellum-dependent cell motility
ZYMOP_RS03135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ZYMOP_RS03140	COG1749	Flagellar hook protein flgE
ZYMOP_RS03145	COG4787	bacterial-type flagellum-dependent cell motility
ZYMOP_RS03155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ZYMOP_RS03160	COG1706	bacterial-type flagellum-dependent cell motility
ZYMOP_RS03185	COG1360	Flagellar Motor Protein
ZYMOP_RS03195	COG0825	malonyl-CoA metabolic process
ZYMOP_RS03200	COG4974	Belongs to the 'phage' integrase family
ZYMOP_RS03210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ZYMOP_RS03215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ZYMOP_RS03245	COG0284	orotidine-5'-phosphate decarboxylase activity
ZYMOP_RS03250	COG0135	phosphoribosylanthranilate isomerase activity
ZYMOP_RS03255	COG0133	tryptophan synthase activity
ZYMOP_RS03260	COG0159	tryptophan synthase activity
ZYMOP_RS03265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ZYMOP_RS03275	COG2223	nitrite transmembrane transporter activity
ZYMOP_RS03285	COG1301	dicarboxylic acid transport
ZYMOP_RS03290	COG1187	pseudouridine synthase activity
ZYMOP_RS03295	COG0742	ribosomal rna small subunit methyltransferase
ZYMOP_RS03305	COG2999	glutathione oxidoreductase activity
ZYMOP_RS03310	COG1116	anion transmembrane transporter activity
ZYMOP_RS03315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ZYMOP_RS03320	COG3459	Glycosyltransferase 36 associated
ZYMOP_RS03330	COG2264	protein methyltransferase activity
ZYMOP_RS03355	COG1643	Atp-dependent helicase
ZYMOP_RS03360	COG0142	geranyltranstransferase activity
ZYMOP_RS03365	COG0287	Prephenate dehydrogenase
ZYMOP_RS03365	COG1605	Chorismate mutase
ZYMOP_RS03370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZYMOP_RS03380	COG2133	pyrroloquinoline quinone binding
ZYMOP_RS03385	COG0779	Required for maturation of 30S ribosomal subunits
ZYMOP_RS03400	COG3064	Membrane
ZYMOP_RS03400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ZYMOP_RS03405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ZYMOP_RS03410	COG1435	thymidine kinase activity
ZYMOP_RS03415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ZYMOP_RS03420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ZYMOP_RS03425	COG1185	polyribonucleotide nucleotidyltransferase activity
ZYMOP_RS03435	COG0038	chloride channel
ZYMOP_RS03445	COG0659	secondary active sulfate transmembrane transporter activity
ZYMOP_RS03450	COG2814	Major facilitator Superfamily
ZYMOP_RS03455	COG0134	indole-3-glycerol-phosphate synthase activity
ZYMOP_RS03475	COG0203	ribosomal protein L17
ZYMOP_RS03480	COG0202	RNA polymerase activity
ZYMOP_RS03485	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ZYMOP_RS03490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ZYMOP_RS03495	COG0563	adenylate kinase activity
ZYMOP_RS03505	COG0200	Binds to the 23S rRNA
ZYMOP_RS03510	COG1841	ribosomal large subunit assembly
ZYMOP_RS03515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ZYMOP_RS03520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ZYMOP_RS03525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ZYMOP_RS03530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ZYMOP_RS03535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ZYMOP_RS03540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ZYMOP_RS03545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ZYMOP_RS03550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ZYMOP_RS03555	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ZYMOP_RS03560	COG0255	Belongs to the universal ribosomal protein uL29 family
ZYMOP_RS03565	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ZYMOP_RS03570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ZYMOP_RS03575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ZYMOP_RS03580	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ZYMOP_RS03585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ZYMOP_RS03590	COG0089	rRNA binding
ZYMOP_RS03595	COG0088	Forms part of the polypeptide exit tunnel
ZYMOP_RS03600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ZYMOP_RS03605	COG0051	transcription antitermination factor activity, RNA binding
ZYMOP_RS03610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ZYMOP_RS03615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ZYMOP_RS03620	COG0049	tRNA binding
ZYMOP_RS03625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ZYMOP_RS03635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ZYMOP_RS03640	COG1607	acyl-coa hydrolase
ZYMOP_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZYMOP_RS03660	COG1956	GAF domain-containing protein
ZYMOP_RS03670	COG0564	pseudouridine synthase activity
ZYMOP_RS03695	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZYMOP_RS03700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZYMOP_RS03725	COG0174	glutamine synthetase
ZYMOP_RS03730	COG0347	Belongs to the P(II) protein family
ZYMOP_RS03735	COG0006	proline dipeptidase activity
ZYMOP_RS03740	COG1770	oligopeptidase
ZYMOP_RS03765	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ZYMOP_RS03785	COG1494	fructose-1,6-bisphosphatase
ZYMOP_RS03795	COG5002	protein histidine kinase activity
ZYMOP_RS03815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZYMOP_RS03815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ZYMOP_RS03830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ZYMOP_RS03840	COG0583	DNA-binding transcription factor activity
ZYMOP_RS03850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ZYMOP_RS03855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ZYMOP_RS03860	COG0149	triose-phosphate isomerase activity
ZYMOP_RS03870	COG0504	CTP synthase activity
ZYMOP_RS03875	COG0442	prolyl-tRNA aminoacylation
ZYMOP_RS03885	COG1136	(ABC) transporter
ZYMOP_RS03890	COG1522	sequence-specific DNA binding
ZYMOP_RS03905	COG1160	GTP binding
ZYMOP_RS03910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZYMOP_RS03950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ZYMOP_RS03950	COG1372	Participates in initiation and elongation during chromosome replication
ZYMOP_RS03955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ZYMOP_RS03990	COG0194	GDP metabolic process
ZYMOP_RS03995	COG2171	N-acyltransferase activity
ZYMOP_RS04005	COG0316	Belongs to the HesB IscA family
ZYMOP_RS04010	COG2151	metal-sulfur cluster biosynthetic enzyme
ZYMOP_RS04015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ZYMOP_RS04020	COG0719	Fe-S assembly protein
ZYMOP_RS04025	COG0396	ATPase activity
ZYMOP_RS04030	COG0719	Fe-S assembly protein
ZYMOP_RS04045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ZYMOP_RS04050	COG0287	Prephenate dehydrogenase
ZYMOP_RS04070	COG2884	Cell division ATP-binding protein ftsE
ZYMOP_RS04085	COG2095	MarC family integral membrane protein
ZYMOP_RS04090	COG0187	DNA topoisomerase II activity
ZYMOP_RS04100	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ZYMOP_RS04105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ZYMOP_RS04130	COG0248	Ppx GppA phosphatase
ZYMOP_RS04135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ZYMOP_RS04140	COG5001	Diguanylate cyclase
ZYMOP_RS04140	COG3300	MHYT domain
ZYMOP_RS04240	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ZYMOP_RS04255	COG1621	beta-fructofuranosidase activity
ZYMOP_RS04260	COG1621	beta-fructofuranosidase activity
ZYMOP_RS04270	COG0837	glucose binding
ZYMOP_RS04275	COG0129	dihydroxy-acid dehydratase activity
ZYMOP_RS04280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ZYMOP_RS04285	COG0477	Major facilitator Superfamily
ZYMOP_RS04290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ZYMOP_RS04295	COG0343	queuine tRNA-ribosyltransferase activity
ZYMOP_RS04300	COG0556	nucleotide-excision repair
ZYMOP_RS04310	COG0772	Belongs to the SEDS family
ZYMOP_RS04335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ZYMOP_RS04360	COG1678	Uncharacterized ACR, COG1678
ZYMOP_RS04365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ZYMOP_RS04370	COG1923	regulation of RNA biosynthetic process
ZYMOP_RS04375	COG0004	ammonium transporteR
ZYMOP_RS04385	COG0312	modulator of DNA gyrase
ZYMOP_RS04395	COG0436	Aminotransferase
ZYMOP_RS04410	COG1192	Involved in chromosome partitioning
ZYMOP_RS04415	COG0352	thiamine-phosphate diphosphorylase activity
ZYMOP_RS04420	COG3108	Peptidase M15
ZYMOP_RS04425	COG0483	inositol monophosphate 1-phosphatase activity
ZYMOP_RS04430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ZYMOP_RS04440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ZYMOP_RS04450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ZYMOP_RS04455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ZYMOP_RS04460	COG0196	riboflavin kinase activity
ZYMOP_RS04490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ZYMOP_RS04500	COG1473	amidohydrolase
ZYMOP_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
ZYMOP_RS04530	COG0667	Aldo Keto reductase
ZYMOP_RS04535	COG2207	Transcriptional regulator
ZYMOP_RS04540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ZYMOP_RS04555	COG1570	exodeoxyribonuclease VII activity
ZYMOP_RS04560	COG0151	Belongs to the GarS family
ZYMOP_RS04570	COG1253	flavin adenine dinucleotide binding
ZYMOP_RS04575	COG0590	tRNA wobble adenosine to inosine editing
ZYMOP_RS04580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ZYMOP_RS04585	COG2814	Major facilitator Superfamily
ZYMOP_RS04590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ZYMOP_RS04595	COG2733	membrane
ZYMOP_RS04620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZYMOP_RS04630	COG1228	amidohydrolase
ZYMOP_RS04635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZYMOP_RS04640	COG1278	Cold shock
ZYMOP_RS04660	COG1137	ATPase activity
ZYMOP_RS04665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ZYMOP_RS04670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ZYMOP_RS04675	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ZYMOP_RS04680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ZYMOP_RS04685	COG4133	protoheme IX ABC transporter activity
ZYMOP_RS04700	COG0277	FAD linked oxidase domain protein
ZYMOP_RS04745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ZYMOP_RS04750	COG0783	Belongs to the Dps family
ZYMOP_RS04755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ZYMOP_RS04760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ZYMOP_RS04765	COG0776	regulation of translation
ZYMOP_RS04775	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZYMOP_RS04780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ZYMOP_RS04785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ZYMOP_RS04790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ZYMOP_RS04795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ZYMOP_RS04800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ZYMOP_RS04805	COG0489	protein tyrosine kinase activity
ZYMOP_RS04810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ZYMOP_RS04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ZYMOP_RS04830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ZYMOP_RS04835	COG4139	cobalamin transport
ZYMOP_RS04845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZYMOP_RS04845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ZYMOP_RS04850	COG4221	oxidoreductase activity
ZYMOP_RS04855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZYMOP_RS04860	COG2813	Specifically methylates the guanine in position
ZYMOP_RS04860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ZYMOP_RS04865	COG1329	Transcriptional regulator
ZYMOP_RS04870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ZYMOP_RS04875	COG4581	dead DEAH box helicase
ZYMOP_RS04880	COG0739	heme binding
ZYMOP_RS04895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ZYMOP_RS04900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ZYMOP_RS04910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ZYMOP_RS04915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ZYMOP_RS04975	COG0840	transmembrane signaling receptor activity
ZYMOP_RS04980	COG0840	transmembrane signaling receptor activity
ZYMOP_RS04990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ZYMOP_RS04995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ZYMOP_RS05005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ZYMOP_RS05010	COG0860	N-Acetylmuramoyl-L-alanine amidase
ZYMOP_RS05015	COG1530	ribonuclease E activity
ZYMOP_RS05035	COG1760	l-serine dehydratase
ZYMOP_RS05050	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ZYMOP_RS05055	COG0215	cysteine-tRNA ligase activity
ZYMOP_RS05065	COG0488	(ABC) transporter
ZYMOP_RS05075	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ZYMOP_RS05080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ZYMOP_RS05085	COG1830	Aldolase
ZYMOP_RS05090	COG0126	phosphoglycerate kinase activity
ZYMOP_RS05095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ZYMOP_RS05125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ZYMOP_RS05135	COG0584	glycerophosphoryl diester phosphodiesterase
ZYMOP_RS05140	COG0583	DNA-binding transcription factor activity
ZYMOP_RS05145	COG0129	dihydroxy-acid dehydratase activity
ZYMOP_RS05195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZYMOP_RS05200	COG1518	maintenance of DNA repeat elements
ZYMOP_RS05215	COG1857	crispr-associated protein
ZYMOP_RS05230	COG1203	CRISPR-associated helicase, Cas3
ZYMOP_RS05235	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ZYMOP_RS05240	COG1794	racemase activity, acting on amino acids and derivatives
ZYMOP_RS05245	COG1522	sequence-specific DNA binding
ZYMOP_RS05270	COG2249	NAD(P)H dehydrogenase (quinone) activity
ZYMOP_RS05280	COG0583	DNA-binding transcription factor activity
ZYMOP_RS05290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZYMOP_RS05295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ZYMOP_RS05300	COG2244	polysaccharide biosynthetic process
ZYMOP_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
ZYMOP_RS05315	COG0625	glutathione transferase activity
ZYMOP_RS05350	COG2885	chlorophyll binding
ZYMOP_RS05355	COG0823	Involved in the tonB-independent uptake of proteins
ZYMOP_RS05365	COG0848	biopolymer transport protein
ZYMOP_RS05375	COG0824	Thioesterase
ZYMOP_RS05380	COG2255	four-way junction helicase activity
ZYMOP_RS05385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ZYMOP_RS05395	COG0632	four-way junction helicase activity
ZYMOP_RS05400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ZYMOP_RS05405	COG0217	transcriptional regulatory protein
ZYMOP_RS05410	COG3750	Belongs to the UPF0335 family
ZYMOP_RS05415	COG0469	pyruvate kinase activity
ZYMOP_RS05420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ZYMOP_RS05440	COG1131	(ABC) transporter
ZYMOP_RS05445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ZYMOP_RS05450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ZYMOP_RS05465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ZYMOP_RS05480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ZYMOP_RS05490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ZYMOP_RS05505	COG0546	phosphoglycolate phosphatase activity
ZYMOP_RS05510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ZYMOP_RS05525	COG0730	response to heat
ZYMOP_RS05535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ZYMOP_RS05540	COG4771	TonB-dependent receptor
ZYMOP_RS05545	COG0371	Dehydrogenase
ZYMOP_RS05555	COG2271	Major facilitator Superfamily
ZYMOP_RS05560	COG4716	Myosin-crossreactive antigen
ZYMOP_RS05575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ZYMOP_RS05580	COG0175	sulfate reduction
ZYMOP_RS05585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ZYMOP_RS05585	COG1648	precorrin-2 dehydrogenase activity
ZYMOP_RS05590	COG0175	sulfate reduction
ZYMOP_RS05620	COG1230	cation diffusion facilitator family transporter
ZYMOP_RS05650	COG2999	glutathione oxidoreductase activity
ZYMOP_RS05670	COG4535	Mg2 and Co2 transporter CorC
ZYMOP_RS05675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ZYMOP_RS05685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ZYMOP_RS05690	COG0835	chemotaxis
ZYMOP_RS05695	COG0745	RESPONSE REGULATOR receiver
ZYMOP_RS05700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ZYMOP_RS05705	COG2201	protein-glutamate methylesterase activity
ZYMOP_RS05710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ZYMOP_RS05715	COG0643	Histidine kinase
ZYMOP_RS05715	COG2198	Histidine kinase
ZYMOP_RS05725	COG0840	transmembrane signaling receptor activity
ZYMOP_RS05735	COG1028	Short-chain dehydrogenase reductase Sdr
ZYMOP_RS05765	COG0066	3-isopropylmalate dehydratase activity
ZYMOP_RS05770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ZYMOP_RS05780	COG2814	Major facilitator Superfamily
ZYMOP_RS05785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ZYMOP_RS05790	COG4774	siderophore transport
ZYMOP_RS05800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ZYMOP_RS05810	COG0488	(ABC) transporter
ZYMOP_RS05825	COG0512	Glutamine amidotransferase of anthranilate synthase
ZYMOP_RS05830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ZYMOP_RS05835	COG1959	2 iron, 2 sulfur cluster binding
ZYMOP_RS05840	COG1151	hydroxylamine reductase activity
ZYMOP_RS05850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZYMOP_RS05855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ZYMOP_RS05860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ZYMOP_RS05865	COG1420	regulation of RNA biosynthetic process
ZYMOP_RS05870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ZYMOP_RS05880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ZYMOP_RS05895	COG1139	Iron-sulfur cluster binding protein
ZYMOP_RS05900	COG0247	lactate metabolic process
ZYMOP_RS05905	COG0138	bifunctional purine biosynthesis protein purh
ZYMOP_RS05915	COG4771	TonB-dependent receptor
ZYMOP_RS05920	COG2983	Belongs to the UPF0260 family
ZYMOP_RS05935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ZYMOP_RS05940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ZYMOP_RS05945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ZYMOP_RS05950	COG0237	dephospho-CoA kinase activity
ZYMOP_RS05955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ZYMOP_RS05960	COG0424	maF-like protein
ZYMOP_RS05990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ZYMOP_RS06000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ZYMOP_RS06015	COG2169	Transcriptional regulator
ZYMOP_RS06015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ZYMOP_RS06020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ZYMOP_RS06030	COG0445	tRNA wobble uridine modification
ZYMOP_RS06035	COG0357	Ribosomal RNA small subunit methyltransferase G
ZYMOP_RS06050	COG0477	Major facilitator Superfamily
ZYMOP_RS06075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ZYMOP_RS06080	COG0372	Belongs to the citrate synthase family
ZYMOP_RS06085	COG2205	protein histidine kinase activity
ZYMOP_RS06110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ZYMOP_RS06110	COG0438	transferase activity, transferring glycosyl groups
ZYMOP_RS06115	COG0497	DNA recombination
ZYMOP_RS06125	COG0459	protein refolding
ZYMOP_RS06130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ZYMOP_RS06135	COG0616	signal peptide processing
ZYMOP_RS06140	COG0826	peptidase U32
ZYMOP_RS06150	COG1368	sulfuric ester hydrolase activity
ZYMOP_RS06175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ZYMOP_RS06180	COG0156	8-amino-7-oxononanoate synthase activity
ZYMOP_RS06190	COG4106	trans-aconitate 2-methyltransferase activity
ZYMOP_RS06190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ZYMOP_RS06195	COG4974	Belongs to the 'phage' integrase family
ZYMOP_RS06200	COG0189	ligase activity
ZYMOP_RS06210	COG0012	GTP binding
ZYMOP_RS06215	COG0193	aminoacyl-tRNA hydrolase activity
ZYMOP_RS06220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ZYMOP_RS06235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ZYMOP_RS06240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ZYMOP_RS06245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ZYMOP_RS06250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ZYMOP_RS06255	COG0181	hydroxymethylbilane synthase activity
ZYMOP_RS06275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ZYMOP_RS06280	COG0416	fatty acid biosynthetic process
ZYMOP_RS06285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ZYMOP_RS06295	COG1862	Preprotein translocase
ZYMOP_RS06300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ZYMOP_RS06325	COG0612	Peptidase, M16
ZYMOP_RS06340	COG2226	methyltransferase
ZYMOP_RS06345	COG3180	Ammonia monooxygenase
ZYMOP_RS06350	COG1902	pentaerythritol trinitrate reductase activity
ZYMOP_RS06355	COG1285	pathogenesis
ZYMOP_RS06360	COG2814	Major facilitator Superfamily
ZYMOP_RS06365	COG0657	acetylesterase activity
ZYMOP_RS06370	COG3180	Ammonia monooxygenase
ZYMOP_RS06385	COG0113	porphobilinogen synthase activity
ZYMOP_RS06390	COG0525	valine-tRNA ligase activity
ZYMOP_RS06415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ZYMOP_RS06425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ZYMOP_RS06445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ZYMOP_RS06505	COG1028	Short-chain dehydrogenase reductase Sdr
ZYMOP_RS06555	COG2084	Dehydrogenase
ZYMOP_RS06590	COG0716	FMN binding
ZYMOP_RS06615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ZYMOP_RS06620	COG1120	ATPase activity
ZYMOP_RS06625	COG1064	alcohol dehydrogenase
ZYMOP_RS06630	COG1733	regulation of RNA biosynthetic process
ZYMOP_RS06635	COG2824	Alkylphosphonate utilization operon protein PhnA
ZYMOP_RS06640	COG0673	inositol 2-dehydrogenase activity
ZYMOP_RS06655	COG4657	Part of a membrane complex involved in electron transport
ZYMOP_RS06665	COG4656	Part of a membrane complex involved in electron transport
ZYMOP_RS06690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ZYMOP_RS06690	COG1618	nucleotide phosphatase activity, acting on free nucleotides
ZYMOP_RS06705	COG3585	molybdate ion transport
ZYMOP_RS06710	COG3585	molybdate ion transport
ZYMOP_RS06715	COG2837	iron assimilation
ZYMOP_RS06740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ZYMOP_RS06745	COG1104	cysteine desulfurase activity
ZYMOP_RS06755	COG0316	Belongs to the HesB IscA family
ZYMOP_RS06775	COG1433	Dinitrogenase iron-molybdenum cofactor
ZYMOP_RS06780	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZYMOP_RS06785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZYMOP_RS06790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZYMOP_RS06795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
ZYMOP_RS06800	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
ZYMOP_RS06815	COG5554	nitrogen fixation
ZYMOP_RS06820	COG5554	nitrogen fixation
ZYMOP_RS06825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ZYMOP_RS06830	COG0535	radical SAM domain protein
ZYMOP_RS06835	COG3604	Transcriptional regulator
ZYMOP_RS06845	COG4657	Part of a membrane complex involved in electron transport
ZYMOP_RS06855	COG4656	Part of a membrane complex involved in electron transport
ZYMOP_RS06890	COG0546	phosphoglycolate phosphatase activity
ZYMOP_RS06895	COG0531	amino acid
ZYMOP_RS06900	COG0776	regulation of translation
ZYMOP_RS06910	COG0539	negative regulation of cytoplasmic translation
ZYMOP_RS06915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ZYMOP_RS06920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ZYMOP_RS06940	COG1132	(ABC) transporter
ZYMOP_RS06960	COG0668	transmembrane transport
ZYMOP_RS07000	COG1733	regulation of RNA biosynthetic process
ZYMOP_RS07015	COG0656	L-ascorbic acid biosynthetic process
ZYMOP_RS07025	COG1979	alcohol dehydrogenase
ZYMOP_RS07035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ZYMOP_RS07040	COG0792	nuclease activity
ZYMOP_RS07050	COG2989	Protein conserved in bacteria
ZYMOP_RS07065	COG0019	diaminopimelate decarboxylase activity
ZYMOP_RS07075	COG0165	Argininosuccinate lyase
ZYMOP_RS07080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ZYMOP_RS07085	COG3265	gluconokinase activity
ZYMOP_RS07090	COG2610	gluconate transmembrane transporter activity
ZYMOP_RS07095	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ZYMOP_RS07100	COG1012	belongs to the aldehyde dehydrogenase family
ZYMOP_RS07120	COG2853	Lipoprotein
ZYMOP_RS07125	COG2226	methyltransferase
ZYMOP_RS07130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ZYMOP_RS07140	COG1410	methionine synthase
ZYMOP_RS07140	COG0646	methionine synthase
ZYMOP_RS07150	COG0481	GTPase activity
ZYMOP_RS07160	COG3275	phosphorelay sensor kinase activity
ZYMOP_RS07165	COG3279	Response regulator of the LytR AlgR family
ZYMOP_RS07190	COG0583	DNA-binding transcription factor activity
ZYMOP_RS07200	COG1045	serine acetyltransferase
ZYMOP_RS07215	COG0436	Aminotransferase
ZYMOP_RS07220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ZYMOP_RS07225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ZYMOP_RS07235	COG1496	oxidoreductase activity
ZYMOP_RS07240	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ZYMOP_RS07250	COG1758	RNA polymerase activity
ZYMOP_RS07255	COG1940	carbohydrate kinase activity
ZYMOP_RS07285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ZYMOP_RS07295	COG0628	permease
ZYMOP_RS07305	COG0736	holo-[acyl-carrier-protein] synthase activity
ZYMOP_RS07310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ZYMOP_RS07315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ZYMOP_RS07330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ZYMOP_RS07345	COG1929	Belongs to the glycerate kinase type-1 family
ZYMOP_RS07350	COG1674	ftsk spoiiie
ZYMOP_RS07365	COG0708	Exodeoxyribonuclease III
ZYMOP_RS07370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZYMOP_RS07370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ZYMOP_RS07385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ZYMOP_RS07390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ZYMOP_RS07395	COG1295	ribonuclease BN
ZYMOP_RS07400	COG0484	heat shock protein binding
ZYMOP_RS07410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ZYMOP_RS07415	COG0354	folic acid binding
ZYMOP_RS07420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ZYMOP_RS07430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ZYMOP_RS07485	COG0656	L-ascorbic acid biosynthetic process
ZYMOP_RS07505	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ZYMOP_RS07515	COG0793	Belongs to the peptidase S41A family
ZYMOP_RS07525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ZYMOP_RS07530	COG0799	negative regulation of ribosome biogenesis
ZYMOP_RS07535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ZYMOP_RS07540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ZYMOP_RS07555	COG0037	tRNA processing
ZYMOP_RS07575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ZYMOP_RS07585	COG2070	2-Nitropropane dioxygenase
ZYMOP_RS07590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ZYMOP_RS07600	COG3386	PFAM SMP-30 Gluconolaconase
ZYMOP_RS07605	COG1573	uracil-dna glycosylase
ZYMOP_RS07610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ZYMOP_RS07620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ZYMOP_RS07630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ZYMOP_RS07635	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ZYMOP_RS07650	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ZYMOP_RS07660	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ZYMOP_RS07670	COG0180	Tryptophanyl-tRNA synthetase
ZYMOP_RS07680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ZYMOP_RS07690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ZYMOP_RS07695	COG0706	membrane insertase activity
ZYMOP_RS07700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ZYMOP_RS07705	COG0594	ribonuclease P activity
ZYMOP_RS07715	COG1720	tRNA m6t6A37 methyltransferase activity
ZYMOP_RS07720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ZYMOP_RS07740	COG0505	Belongs to the CarA family
ZYMOP_RS07750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ZYMOP_RS07780	COG0148	phosphopyruvate hydratase activity
ZYMOP_RS07800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ZYMOP_RS07805	COG0022	dehydrogenase e1 component
ZYMOP_RS07805	COG0508	dehydrogenase complex catalyzes the overall conversion of
ZYMOP_RS07815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ZYMOP_RS07815	COG3453	Protein conserved in bacteria
ZYMOP_RS07820	COG1335	isochorismatase
ZYMOP_RS07825	COG0328	RNA-DNA hybrid ribonuclease activity
ZYMOP_RS07830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ZYMOP_RS07840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ZYMOP_RS07845	COG1454	alcohol dehydrogenase
ZYMOP_RS07855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ZYMOP_RS07860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ZYMOP_RS07865	COG1127	ABC transporter
ZYMOP_RS07870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ZYMOP_RS07885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ZYMOP_RS07905	COG0667	Aldo Keto reductase
ZYMOP_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
ZYMOP_RS07970	COG2814	Major facilitator Superfamily
ZYMOP_RS07995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ZYMOP_RS08000	COG0803	Belongs to the bacterial solute-binding protein 9 family
ZYMOP_RS08010	COG1294	oxidase, subunit
ZYMOP_RS08015	COG1271	oxidase subunit
ZYMOP_RS08025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ZYMOP_RS08055	COG1051	belongs to the nudix hydrolase family
ZYMOP_RS08060	COG0300	oxidoreductase activity
ZYMOP_RS08065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ZYMOP_RS08080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ZYMOP_RS08085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ZYMOP_RS08090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ZYMOP_RS08095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ZYMOP_RS08120	COG0629	single-stranded DNA binding
ZYMOP_RS08145	COG0047	phosphoribosylformylglycinamidine synthase activity
ZYMOP_RS08150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ZYMOP_RS08155	COG0517	IMP dehydrogenase activity
ZYMOP_RS08155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ZYMOP_RS08160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ZYMOP_RS08175	COG1538	Outer membrane efflux protein
ZYMOP_RS08185	COG4206	TonB-dependent receptor
ZYMOP_RS08200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ZYMOP_RS08210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ZYMOP_RS08215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ZYMOP_RS08220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ZYMOP_RS08225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ZYMOP_RS08225	COG0072	phenylalanine-tRNA ligase activity
ZYMOP_RS08230	COG5265	(ABC) transporter
ZYMOP_RS08240	COG2890	protein-(glutamine-N5) methyltransferase activity
ZYMOP_RS08245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ZYMOP_RS08250	COG0124	histidyl-tRNA synthetase
ZYMOP_RS08255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ZYMOP_RS08270	COG0131	Imidazoleglycerol-phosphate dehydratase
ZYMOP_RS08275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ZYMOP_RS08280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ZYMOP_RS08285	COG0107	imidazoleglycerol-phosphate synthase activity
ZYMOP_RS08290	COG0140	phosphoribosyl-ATP diphosphatase activity
ZYMOP_RS08300	COG0531	amino acid
ZYMOP_RS08305	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ZYMOP_RS08315	COG2096	Adenosyltransferase
ZYMOP_RS08320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ZYMOP_RS08345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ZYMOP_RS08350	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ZYMOP_RS08370	COG0045	succinate-CoA ligase (ADP-forming) activity
ZYMOP_RS08375	COG2086	electron transfer activity
ZYMOP_RS08425	COG0246	Mannitol dehydrogenase
ZYMOP_RS08450	COG0752	glycyl-tRNA synthetase alpha subunit
ZYMOP_RS08455	COG0751	glycine-tRNA ligase activity
ZYMOP_RS08470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ZYMOP_RS08480	COG0495	leucyl-tRNA aminoacylation
ZYMOP_RS08505	COG1566	PFAM secretion protein HlyD family protein
ZYMOP_RS08515	COG2003	Belongs to the UPF0758 family
ZYMOP_RS08530	COG0612	Peptidase, M16
ZYMOP_RS08535	COG0612	Peptidase, M16
ZYMOP_RS08540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ZYMOP_RS08545	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ZYMOP_RS08555	COG0513	Belongs to the DEAD box helicase family
ZYMOP_RS08575	COG4957	zinc ion binding
ZYMOP_RS08605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ZYMOP_RS08610	COG0596	Alpha beta hydrolase
ZYMOP_RS08615	COG0784	Response regulator, receiver
ZYMOP_RS08625	COG0739	heme binding
ZYMOP_RS08635	COG0708	Exodeoxyribonuclease III
ZYMOP_RS08695	COG0405	Gamma-glutamyltransferase
ZYMOP_RS08715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ZYMOP_RS08720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ZYMOP_RS08750	COG0571	ribonuclease III activity
ZYMOP_RS08790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ZYMOP_RS08800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ZYMOP_RS08810	COG3961	Belongs to the TPP enzyme family
ZYMOP_RS09085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ZYMOP_RS09200	COG0626	cystathionine gamma-synthase activity
ZYMOP_RS09235	COG1621	beta-fructofuranosidase activity