locus-tag	class	description
HIMB5_RS00005	COG0336	Belongs to the RNA methyltransferase TrmD family
HIMB5_RS00010	COG0335	large ribosomal subunit rRNA binding
HIMB5_RS00015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HIMB5_RS00020	COG0066	3-isopropylmalate dehydratase activity
HIMB5_RS00025	COG0473	3-isopropylmalate dehydrogenase activity
HIMB5_RS00030	COG1960	acyl-CoA dehydrogenase activity
HIMB5_RS00045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS00050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HIMB5_RS00065	COG1053	succinate dehydrogenase
HIMB5_RS00080	COG0039	L-malate dehydrogenase activity
HIMB5_RS00085	COG0045	succinate-CoA ligase (ADP-forming) activity
HIMB5_RS00090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HIMB5_RS00100	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIMB5_RS00115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIMB5_RS00120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIMB5_RS00125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HIMB5_RS00130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HIMB5_RS00135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HIMB5_RS00140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HIMB5_RS00145	COG1051	belongs to the nudix hydrolase family
HIMB5_RS00150	COG0793	Belongs to the peptidase S41A family
HIMB5_RS00160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HIMB5_RS00165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HIMB5_RS00170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HIMB5_RS00175	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HIMB5_RS00180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HIMB5_RS00185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HIMB5_RS00190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIMB5_RS00195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIMB5_RS00195	COG2813	Specifically methylates the guanine in position
HIMB5_RS00200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIMB5_RS00205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HIMB5_RS00210	COG0287	Prephenate dehydrogenase
HIMB5_RS00215	COG0457	Tetratricopeptide repeat
HIMB5_RS00225	COG2223	nitrite transmembrane transporter activity
HIMB5_RS00230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HIMB5_RS00235	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HIMB5_RS00240	COG0167	dihydroorotate dehydrogenase activity
HIMB5_RS00245	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HIMB5_RS00250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HIMB5_RS00255	COG0010	Belongs to the arginase family
HIMB5_RS00265	COG0019	diaminopimelate decarboxylase activity
HIMB5_RS00270	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HIMB5_RS00280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIMB5_RS00280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HIMB5_RS00285	COG0745	RESPONSE REGULATOR receiver
HIMB5_RS00290	COG2205	protein histidine kinase activity
HIMB5_RS00295	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HIMB5_RS00300	COG0802	atpase or kinase
HIMB5_RS00310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HIMB5_RS00315	COG0588	phosphoglycerate mutase activity
HIMB5_RS00330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIMB5_RS00345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIMB5_RS00355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HIMB5_RS00375	COG2252	PERMEase
HIMB5_RS00405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIMB5_RS00410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIMB5_RS00430	COG0312	modulator of DNA gyrase
HIMB5_RS00435	COG0312	modulator of DNA gyrase
HIMB5_RS00450	COG2364	Membrane
HIMB5_RS00455	COG1217	gtp-binding protein TYPA
HIMB5_RS00460	COG0459	protein refolding
HIMB5_RS00465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HIMB5_RS00475	COG0196	riboflavin kinase activity
HIMB5_RS00480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIMB5_RS00485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HIMB5_RS00495	COG0166	Belongs to the GPI family
HIMB5_RS00520	COG1663	tetraacyldisaccharide 4'-kinase activity
HIMB5_RS00530	COG1132	(ABC) transporter
HIMB5_RS00535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HIMB5_RS00550	COG1741	Belongs to the pirin family
HIMB5_RS00560	COG1733	regulation of RNA biosynthetic process
HIMB5_RS00575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HIMB5_RS00580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HIMB5_RS00585	COG0109	protoheme IX farnesyltransferase activity
HIMB5_RS00595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HIMB5_RS00615	COG0678	peroxiredoxin activity
HIMB5_RS00625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HIMB5_RS00630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HIMB5_RS00660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HIMB5_RS00665	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HIMB5_RS00670	COG0356	it plays a direct role in the translocation of protons across the membrane
HIMB5_RS00680	COG1196	nuclear chromosome segregation
HIMB5_RS00695	COG1194	a g-specific adenine glycosylase
HIMB5_RS00705	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HIMB5_RS00710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIMB5_RS00725	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HIMB5_RS00735	COG0617	tRNA 3'-terminal CCA addition
HIMB5_RS00740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIMB5_RS00745	COG0408	coproporphyrinogen oxidase activity
HIMB5_RS00750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HIMB5_RS00755	COG0723	plastoquinol--plastocyanin reductase activity
HIMB5_RS00765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HIMB5_RS00765	COG2857	Cytochrome c1
HIMB5_RS00770	COG0012	GTP binding
HIMB5_RS00775	COG0193	aminoacyl-tRNA hydrolase activity
HIMB5_RS00780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HIMB5_RS00785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIMB5_RS00790	COG1496	oxidoreductase activity
HIMB5_RS00800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HIMB5_RS00815	COG0745	RESPONSE REGULATOR receiver
HIMB5_RS00825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIMB5_RS00830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIMB5_RS00835	COG0322	excinuclease ABC activity
HIMB5_RS00845	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB5_RS00850	COG0556	nucleotide-excision repair
HIMB5_RS00860	COG0492	ferredoxin-NADP+ reductase activity
HIMB5_RS00880	COG0505	Belongs to the CarA family
HIMB5_RS00890	COG0358	DNA primase activity
HIMB5_RS00895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HIMB5_RS00925	COG2853	Lipoprotein
HIMB5_RS00930	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIMB5_RS00935	COG2001	Belongs to the MraZ family
HIMB5_RS00945	COG0275	rRNA processing
HIMB5_RS00980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HIMB5_RS00985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HIMB5_RS00990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HIMB5_RS00995	COG1181	Belongs to the D-alanine--D-alanine ligase family
HIMB5_RS01015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HIMB5_RS01020	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIMB5_RS01025	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HIMB5_RS01030	COG0006	proline dipeptidase activity
HIMB5_RS01055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS01080	COG0633	Ferredoxin
HIMB5_RS01085	COG0492	ferredoxin-NADP+ reductase activity
HIMB5_RS01090	COG0625	glutathione transferase activity
HIMB5_RS01105	COG0463	Glycosyl transferase, family 2
HIMB5_RS01120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIMB5_RS01140	COG0572	uridine kinase
HIMB5_RS01150	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HIMB5_RS01155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HIMB5_RS01160	COG0538	isocitrate dehydrogenase activity
HIMB5_RS01165	COG0688	phosphatidylethanolamine metabolic process
HIMB5_RS01170	COG1183	phosphatidylcholine synthase activity
HIMB5_RS01180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HIMB5_RS01195	COG0519	Catalyzes the synthesis of GMP from XMP
HIMB5_RS01200	COG0346	lactoylglutathione lyase activity
HIMB5_RS01210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HIMB5_RS01225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HIMB5_RS01230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HIMB5_RS01235	COG1984	allophanate hydrolase subunit 2
HIMB5_RS01245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS01250	COG0509	glycine decarboxylation via glycine cleavage system
HIMB5_RS01255	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HIMB5_RS01255	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HIMB5_RS01270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIMB5_RS01280	COG0300	oxidoreductase activity
HIMB5_RS01285	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HIMB5_RS01295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HIMB5_RS01300	COG3383	formate dehydrogenase (NAD+) activity
HIMB5_RS01310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HIMB5_RS01325	COG0746	molybdenum cofactor guanylyltransferase activity
HIMB5_RS01330	COG0303	'Molybdopterin
HIMB5_RS01360	COG0006	proline dipeptidase activity
HIMB5_RS01385	COG0189	ligase activity
HIMB5_RS01390	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HIMB5_RS01395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIMB5_RS01410	COG0305	Participates in initiation and elongation during chromosome replication
HIMB5_RS01415	COG0359	binds to the 23S rRNA
HIMB5_RS01420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HIMB5_RS01425	COG0360	Binds together with S18 to 16S ribosomal RNA
HIMB5_RS01430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HIMB5_RS01435	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB5_RS01440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIMB5_RS01445	COG0194	GDP metabolic process
HIMB5_RS01450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HIMB5_RS01455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HIMB5_RS01460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIMB5_RS01465	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HIMB5_RS01480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HIMB5_RS01490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIMB5_RS01510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HIMB5_RS01515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIMB5_RS01530	COG0439	Biotin carboxylase
HIMB5_RS01535	COG0511	ligase activity, forming carbon-carbon bonds
HIMB5_RS01540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HIMB5_RS01545	COG2104	thiamine diphosphate biosynthetic process
HIMB5_RS01550	COG2022	thiamine diphosphate biosynthetic process
HIMB5_RS01555	COG1530	ribonuclease E activity
HIMB5_RS01560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HIMB5_RS01575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIMB5_RS01580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HIMB5_RS01585	COG2945	thiolester hydrolase activity
HIMB5_RS01595	COG0719	Fe-S assembly protein
HIMB5_RS01600	COG0396	ATPase activity
HIMB5_RS01605	COG0719	Fe-S assembly protein
HIMB5_RS01610	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIMB5_RS01615	COG0822	iron-sulfur transferase activity
HIMB5_RS01625	COG0316	Belongs to the HesB IscA family
HIMB5_RS01630	COG0174	glutamine synthetase
HIMB5_RS01665	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIMB5_RS01705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HIMB5_RS01720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HIMB5_RS01725	COG0314	molybdopterin synthase activity
HIMB5_RS01740	COG0315	cyclic pyranopterin monophosphate synthase activity
HIMB5_RS01745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HIMB5_RS01760	COG1012	belongs to the aldehyde dehydrogenase family
HIMB5_RS01765	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB5_RS01770	COG1940	carbohydrate kinase activity
HIMB5_RS01780	COG1175	transmembrane transport
HIMB5_RS01785	COG0395	ABC-type sugar transport system, permease component
HIMB5_RS01790	COG3842	ATPase activity
HIMB5_RS01800	COG0129	dihydroxy-acid dehydratase activity
HIMB5_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB5_RS01820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HIMB5_RS01825	COG0785	Cytochrome C biogenesis protein
HIMB5_RS01830	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HIMB5_RS01870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HIMB5_RS01875	COG1045	serine acetyltransferase
HIMB5_RS01895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HIMB5_RS01905	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HIMB5_RS01915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIMB5_RS01920	COG1116	anion transmembrane transporter activity
HIMB5_RS01930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HIMB5_RS01935	COG0686	Belongs to the AlaDH PNT family
HIMB5_RS01965	COG2175	clavaminate synthase activity
HIMB5_RS01970	COG0457	Tetratricopeptide repeat
HIMB5_RS02010	COG0438	transferase activity, transferring glycosyl groups
HIMB5_RS02020	COG1368	sulfuric ester hydrolase activity
HIMB5_RS02030	COG1088	dTDP-glucose 4,6-dehydratase activity
HIMB5_RS02035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HIMB5_RS02040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIMB5_RS02045	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HIMB5_RS02105	COG2084	Dehydrogenase
HIMB5_RS02115	COG1758	RNA polymerase activity
HIMB5_RS02120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIMB5_RS02125	COG0730	response to heat
HIMB5_RS02140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIMB5_RS02145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIMB5_RS02160	COG2224	Isocitrate lyase
HIMB5_RS02185	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS02200	COG0288	reversible hydration of carbon dioxide
HIMB5_RS02210	COG1136	(ABC) transporter
HIMB5_RS02230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIMB5_RS02260	COG4608	Belongs to the ABC transporter superfamily
HIMB5_RS02265	COG0444	Belongs to the ABC transporter superfamily
HIMB5_RS02270	COG0601	transmembrane transport
HIMB5_RS02275	COG0747	negative chemotaxis
HIMB5_RS02320	COG1666	GTP binding
HIMB5_RS02325	COG0750	zinc metalloprotease
HIMB5_RS02330	COG0776	regulation of translation
HIMB5_RS02335	COG0004	ammonium transporteR
HIMB5_RS02340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HIMB5_RS02350	COG1054	Belongs to the UPF0176 family
HIMB5_RS02375	COG1218	3'(2'),5'-bisphosphate nucleotidase
HIMB5_RS02380	COG0482	sulfurtransferase activity
HIMB5_RS02390	COG0626	cystathionine gamma-synthase activity
HIMB5_RS02405	COG0512	Glutamine amidotransferase of anthranilate synthase
HIMB5_RS02415	COG0537	adenosine 5'-monophosphoramidase activity
HIMB5_RS02460	COG2721	sulfolactate sulfo-lyase activity
HIMB5_RS02465	COG0028	Belongs to the TPP enzyme family
HIMB5_RS02520	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB5_RS02525	COG1028	Short-chain dehydrogenase reductase Sdr
HIMB5_RS02530	COG0861	Integral membrane protein TerC family
HIMB5_RS02555	COG1953	Uracil, thiamine, allantoin
HIMB5_RS02575	COG0824	Thioesterase
HIMB5_RS02610	COG0544	peptidyl-prolyl cis-trans isomerase activity
HIMB5_RS02615	COG0740	serine-type endopeptidase activity
HIMB5_RS02620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HIMB5_RS02640	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB5_RS02645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB5_RS02650	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB5_RS02655	COG0649	NAD binding
HIMB5_RS02660	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HIMB5_RS02670	COG1034	ATP synthesis coupled electron transport
HIMB5_RS02675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HIMB5_RS02680	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIMB5_RS02690	COG0713	ATP synthesis coupled electron transport
HIMB5_RS02705	COG1007	ATP synthesis coupled electron transport
HIMB5_RS02715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HIMB5_RS02730	COG0442	prolyl-tRNA aminoacylation
HIMB5_RS02735	COG4591	ABC-type transport system involved in lipoprotein release permease component
HIMB5_RS02740	COG1136	(ABC) transporter
HIMB5_RS02750	COG0052	Belongs to the universal ribosomal protein uS2 family
HIMB5_RS02755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HIMB5_RS02760	COG0233	cytoplasmic translational termination
HIMB5_RS02770	COG0575	Belongs to the CDS family
HIMB5_RS02780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIMB5_RS02790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HIMB5_RS02795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIMB5_RS02800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIMB5_RS02805	COG3494	Protein of unknown function (DUF1009)
HIMB5_RS02815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIMB5_RS02820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIMB5_RS02825	COG0134	indole-3-glycerol-phosphate synthase activity
HIMB5_RS02830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIMB5_RS02835	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIMB5_RS02835	COG0512	Glutamine amidotransferase of anthranilate synthase
HIMB5_RS02840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HIMB5_RS02850	COG0149	triose-phosphate isomerase activity
HIMB5_RS02860	COG0504	CTP synthase activity
HIMB5_RS02865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HIMB5_RS02870	COG0148	phosphopyruvate hydratase activity
HIMB5_RS02880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIMB5_RS02900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HIMB5_RS02900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HIMB5_RS02905	COG5000	phosphorelay sensor kinase activity
HIMB5_RS02910	COG2204	response regulator
HIMB5_RS02915	COG0569	domain protein
HIMB5_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIMB5_RS02935	COG4597	amino acid ABC transporter
HIMB5_RS02940	COG0765	amino acid transport
HIMB5_RS02945	COG1126	abc transporter atp-binding protein
HIMB5_RS02950	COG1396	sequence-specific DNA binding
HIMB5_RS02965	COG0525	valine-tRNA ligase activity
HIMB5_RS02970	COG0129	dihydroxy-acid dehydratase activity
HIMB5_RS02975	COG0662	Cupin 2, conserved barrel domain protein
HIMB5_RS02975	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HIMB5_RS02985	COG5002	protein histidine kinase activity
HIMB5_RS02995	COG0573	inorganic phosphate transmembrane transporter activity
HIMB5_RS03000	COG0581	inorganic phosphate transmembrane transporter activity
HIMB5_RS03005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HIMB5_RS03015	COG0745	RESPONSE REGULATOR receiver
HIMB5_RS03030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIMB5_RS03035	COG1121	(ABC) transporter
HIMB5_RS03060	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HIMB5_RS03065	COG0018	arginyl-trna synthetase
HIMB5_RS03075	COG1472	Belongs to the glycosyl hydrolase 3 family
HIMB5_RS03080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIMB5_RS03090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HIMB5_RS03095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HIMB5_RS03100	COG0805	protein transport
HIMB5_RS03105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HIMB5_RS03115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIMB5_RS03130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HIMB5_RS03135	COG0629	single-stranded DNA binding
HIMB5_RS03140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HIMB5_RS03145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HIMB5_RS03155	COG0343	queuine tRNA-ribosyltransferase activity
HIMB5_RS03175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIMB5_RS03190	COG2962	Rard protein
HIMB5_RS03195	COG2951	lytic endotransglycosylase activity
HIMB5_RS03205	COG1686	Belongs to the peptidase S11 family
HIMB5_RS03215	COG0470	DNA polymerase III
HIMB5_RS03220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIMB5_RS03225	COG0084	hydrolase, TatD family'
HIMB5_RS03230	COG0321	lipoyl(octanoyl) transferase activity
HIMB5_RS03230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HIMB5_RS03235	COG0386	Belongs to the glutathione peroxidase family
HIMB5_RS03240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HIMB5_RS03260	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HIMB5_RS03265	COG1494	fructose-1,6-bisphosphatase
HIMB5_RS03280	COG2827	Endonuclease containing a URI domain
HIMB5_RS03325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIMB5_RS03325	COG2169	Transcriptional regulator
HIMB5_RS03345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HIMB5_RS03350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HIMB5_RS03355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HIMB5_RS03365	COG1612	heme a metabolic process
HIMB5_RS03385	COG0776	regulation of translation
HIMB5_RS03390	COG0416	fatty acid biosynthetic process
HIMB5_RS03395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HIMB5_RS03410	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HIMB5_RS03415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HIMB5_RS03420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HIMB5_RS03425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HIMB5_RS03430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HIMB5_RS03430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HIMB5_RS03435	COG0307	riboflavin synthase, alpha
HIMB5_RS03440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIMB5_RS03440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIMB5_RS03445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HIMB5_RS03450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HIMB5_RS03455	COG0698	ribose 5-phosphate isomerase
HIMB5_RS03465	COG0113	porphobilinogen synthase activity
HIMB5_RS03470	COG1381	Involved in DNA repair and RecF pathway recombination
HIMB5_RS03475	COG0571	ribonuclease III activity
HIMB5_RS03480	COG0681	Belongs to the peptidase S26 family
HIMB5_RS03485	COG0736	holo-[acyl-carrier-protein] synthase activity
HIMB5_RS03490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HIMB5_RS03500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIMB5_RS03505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HIMB5_RS03510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HIMB5_RS03515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIMB5_RS03540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS03540	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIMB5_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIMB5_RS03555	COG0765	amino acid transport
HIMB5_RS03570	COG1054	Belongs to the UPF0176 family
HIMB5_RS03575	COG4122	O-methyltransferase activity
HIMB5_RS03580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIMB5_RS03585	COG0154	amidase activity
HIMB5_RS03590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIMB5_RS03595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIMB5_RS03600	COG0540	Belongs to the ATCase OTCase family
HIMB5_RS03605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HIMB5_RS03610	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HIMB5_RS03615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIMB5_RS03620	COG0251	oxidation-reduction process
HIMB5_RS03625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HIMB5_RS03635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HIMB5_RS03640	COG2239	Acts as a magnesium transporter
HIMB5_RS03645	COG0321	lipoyl(octanoyl) transferase activity
HIMB5_RS03650	COG0564	pseudouridine synthase activity
HIMB5_RS03655	COG0203	ribosomal protein L17
HIMB5_RS03660	COG0202	RNA polymerase activity
HIMB5_RS03665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HIMB5_RS03670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HIMB5_RS03675	COG0563	adenylate kinase activity
HIMB5_RS03680	COG0201	protein transport
HIMB5_RS03685	COG0200	Binds to the 23S rRNA
HIMB5_RS03690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HIMB5_RS03695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HIMB5_RS03700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HIMB5_RS03705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HIMB5_RS03710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HIMB5_RS03715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HIMB5_RS03720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HIMB5_RS03725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HIMB5_RS03730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HIMB5_RS03740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HIMB5_RS03745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HIMB5_RS03750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HIMB5_RS03755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HIMB5_RS03760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HIMB5_RS03765	COG0089	rRNA binding
HIMB5_RS03770	COG0088	Forms part of the polypeptide exit tunnel
HIMB5_RS03775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HIMB5_RS03780	COG0051	transcription antitermination factor activity, RNA binding
HIMB5_RS03785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HIMB5_RS03790	COG0049	tRNA binding
HIMB5_RS03795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HIMB5_RS03800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HIMB5_RS03805	COG0085	RNA polymerase activity
HIMB5_RS03810	COG0222	ribosome binding
HIMB5_RS03815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HIMB5_RS03820	COG0081	regulation of translation
HIMB5_RS03825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HIMB5_RS03830	COG0250	Participates in transcription elongation, termination and antitermination
HIMB5_RS03835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HIMB5_RS03845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HIMB5_RS03890	COG1546	Belongs to the CinA family
HIMB5_RS03890	COG1058	Belongs to the CinA family
HIMB5_RS03895	COG1489	DNA binding
HIMB5_RS03900	COG0024	Methionine aminopeptidase
HIMB5_RS03905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIMB5_RS03910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HIMB5_RS03915	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIMB5_RS03920	COG0047	phosphoribosylformylglycinamidine synthase activity
HIMB5_RS03925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIMB5_RS03935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HIMB5_RS03940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HIMB5_RS03945	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HIMB5_RS03950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIMB5_RS03955	COG0215	cysteine-tRNA ligase activity
HIMB5_RS03960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HIMB5_RS03965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HIMB5_RS03970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HIMB5_RS03975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HIMB5_RS03980	COG0546	phosphoglycolate phosphatase activity
HIMB5_RS03985	COG2079	MmgE PrpD family protein
HIMB5_RS03990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HIMB5_RS04005	COG0714	Associated with various cellular activities
HIMB5_RS04025	COG0463	Glycosyl transferase, family 2
HIMB5_RS04070	COG0464	growth
HIMB5_RS04130	COG4969	Belongs to the N-Me-Phe pilin family
HIMB5_RS04140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HIMB5_RS04180	COG0842	Transport permease protein
HIMB5_RS04185	COG1131	(ABC) transporter
HIMB5_RS04240	COG0473	3-isopropylmalate dehydrogenase activity
HIMB5_RS04285	COG0534	Mate efflux family protein
HIMB5_RS04295	COG3453	Protein conserved in bacteria
HIMB5_RS04295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIMB5_RS04325	COG3842	ATPase activity
HIMB5_RS04335	COG1840	ABC-type Fe3 transport system, periplasmic component
HIMB5_RS04340	COG0583	DNA-binding transcription factor activity
HIMB5_RS04345	COG0604	alcohol dehydrogenase
HIMB5_RS04350	COG0302	gtp cyclohydrolase
HIMB5_RS04355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIMB5_RS04375	COG2086	electron transfer activity
HIMB5_RS04390	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIMB5_RS04410	COG1832	CoA-binding protein
HIMB5_RS04415	COG1024	Enoyl-CoA hydratase
HIMB5_RS04420	COG4948	Mandelate Racemase Muconate Lactonizing
HIMB5_RS04430	COG0235	Class ii aldolase
HIMB5_RS04460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HIMB5_RS04465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS04495	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIMB5_RS04500	COG0165	Argininosuccinate lyase
HIMB5_RS04500	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HIMB5_RS04525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS04525	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIMB5_RS04535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIMB5_RS04540	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HIMB5_RS04550	COG2072	flavoprotein involved in K transport
HIMB5_RS04565	COG0395	ABC-type sugar transport system, permease component
HIMB5_RS04575	COG3842	ATPase activity
HIMB5_RS04580	COG3842	ATPase activity
HIMB5_RS04595	COG4176	ABC-type proline glycine betaine transport system permease component
HIMB5_RS04600	COG0517	IMP dehydrogenase activity
HIMB5_RS04600	COG4175	Glycine betaine
HIMB5_RS04620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HIMB5_RS04630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIMB5_RS04650	COG0069	glutamate synthase activity
HIMB5_RS04660	COG0004	ammonium transporteR
HIMB5_RS04675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HIMB5_RS04680	COG2218	PFAM glutamate synthase alpha subunit domain protein
HIMB5_RS04685	COG0069	glutamate synthase activity
HIMB5_RS04690	COG0174	glutamine synthetase
HIMB5_RS04700	COG0415	Belongs to the DNA photolyase family
HIMB5_RS04705	COG0432	Pfam Uncharacterised protein family UPF0047
HIMB5_RS04710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HIMB5_RS04730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HIMB5_RS04740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIMB5_RS04745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HIMB5_RS04770	COG1024	Enoyl-CoA hydratase
HIMB5_RS04770	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIMB5_RS04775	COG1177	transmembrane transport
HIMB5_RS04790	COG3842	ATPase activity
HIMB5_RS04795	COG0006	proline dipeptidase activity
HIMB5_RS04845	COG1012	belongs to the aldehyde dehydrogenase family
HIMB5_RS04940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HIMB5_RS04945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HIMB5_RS04950	COG0123	including yeast histone deacetylase and acetoin utilization protein
HIMB5_RS04955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HIMB5_RS04970	COG0772	Belongs to the SEDS family
HIMB5_RS04975	COG0768	penicillin binding
HIMB5_RS04985	COG1792	Involved in formation and maintenance of cell shape
HIMB5_RS04995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIMB5_RS05005	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HIMB5_RS05020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HIMB5_RS05025	COG0440	acetolactate synthase activity
HIMB5_RS05030	COG0028	Belongs to the TPP enzyme family
HIMB5_RS05035	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HIMB5_RS05050	COG0330	HflC and HflK could
HIMB5_RS05055	COG0330	HflC and HflK could
HIMB5_RS05060	COG0489	protein tyrosine kinase activity
HIMB5_RS05065	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HIMB5_RS05080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HIMB5_RS05090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIMB5_RS05090	COG0574	Belongs to the PEP-utilizing enzyme family
HIMB5_RS05100	COG0752	glycyl-tRNA synthetase alpha subunit
HIMB5_RS05110	COG0142	geranyltranstransferase activity
HIMB5_RS05115	COG0259	pyridoxamine-phosphate oxidase activity
HIMB5_RS05120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HIMB5_RS05125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HIMB5_RS05130	COG0142	geranyltranstransferase activity
HIMB5_RS05140	COG0009	L-threonylcarbamoyladenylate synthase
HIMB5_RS05160	COG0564	pseudouridine synthase activity
HIMB5_RS05170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIMB5_RS05175	COG0352	thiamine-phosphate diphosphorylase activity
HIMB5_RS05175	COG0351	phosphomethylpyrimidine kinase
HIMB5_RS05180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIMB5_RS05205	COG2885	chlorophyll binding
HIMB5_RS05210	COG0823	Involved in the tonB-independent uptake of proteins
HIMB5_RS05235	COG0217	transcriptional regulatory protein
HIMB5_RS05240	COG1692	metallophosphoesterase
HIMB5_RS05245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIMB5_RS05270	COG0126	phosphoglycerate kinase activity
HIMB5_RS05275	COG3588	fructose-bisphosphate aldolase
HIMB5_RS05280	COG0352	thiamine-phosphate diphosphorylase activity
HIMB5_RS05285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HIMB5_RS05290	COG0483	inositol monophosphate 1-phosphatase activity
HIMB5_RS05295	COG0254	rRNA binding
HIMB5_RS05305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HIMB5_RS05315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HIMB5_RS05340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HIMB5_RS05350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIMB5_RS05355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIMB5_RS05360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HIMB5_RS05390	COG1215	transferase activity, transferring glycosyl groups
HIMB5_RS05415	COG0463	Glycosyl transferase, family 2
HIMB5_RS05445	COG1086	Polysaccharide biosynthesis protein
HIMB5_RS05450	COG1132	(ABC) transporter
HIMB5_RS05470	COG1083	cytidylyl-transferase
HIMB5_RS05475	COG1215	transferase activity, transferring glycosyl groups
HIMB5_RS05480	COG0673	inositol 2-dehydrogenase activity
HIMB5_RS05485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HIMB5_RS05485	COG1605	Chorismate mutase
HIMB5_RS05495	COG0367	asparagine synthase
HIMB5_RS05510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIMB5_RS05515	COG2133	pyrroloquinoline quinone binding
HIMB5_RS05525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HIMB5_RS05535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HIMB5_RS05540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HIMB5_RS05550	COG2089	acid synthase
HIMB5_RS05600	COG0739	heme binding
HIMB5_RS05615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HIMB5_RS05620	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HIMB5_RS05625	COG0527	aspartate kinase activity
HIMB5_RS05630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HIMB5_RS05640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HIMB5_RS05645	COG0653	protein targeting
HIMB5_RS05650	COG0825	malonyl-CoA metabolic process
HIMB5_RS05660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIMB5_RS05665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HIMB5_RS05670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIMB5_RS05680	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HIMB5_RS05685	COG3474	cytochrome
HIMB5_RS05690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HIMB5_RS05695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIMB5_RS05715	COG0517	IMP dehydrogenase activity
HIMB5_RS05715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HIMB5_RS05725	COG1137	ATPase activity
HIMB5_RS05730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HIMB5_RS05735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HIMB5_RS05740	COG0539	negative regulation of cytoplasmic translation
HIMB5_RS05745	COG0776	regulation of translation
HIMB5_RS05750	COG0284	orotidine-5'-phosphate decarboxylase activity
HIMB5_RS05755	COG0135	phosphoribosylanthranilate isomerase activity
HIMB5_RS05760	COG0133	tryptophan synthase activity
HIMB5_RS05765	COG0159	tryptophan synthase activity
HIMB5_RS05770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HIMB5_RS05775	COG0285	dihydrofolate synthase activity
HIMB5_RS05780	COG3118	belongs to the thioredoxin family
HIMB5_RS05830	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HIMB5_RS05845	COG0202	RNA polymerase activity
HIMB5_RS05870	COG1104	cysteine desulfurase activity
HIMB5_RS05970	COG0612	Peptidase, M16
HIMB5_RS05980	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HIMB5_RS05985	COG0124	histidyl-tRNA synthetase
HIMB5_RS05995	COG1278	Cold shock
HIMB5_RS06005	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HIMB5_RS06010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HIMB5_RS06020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIMB5_RS06025	COG0717	Belongs to the dCTP deaminase family
HIMB5_RS06050	COG0594	ribonuclease P activity
HIMB5_RS06055	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HIMB5_RS06060	COG0706	membrane insertase activity
HIMB5_RS06065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HIMB5_RS06075	COG2171	N-acyltransferase activity
HIMB5_RS06080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HIMB5_RS06085	COG0123	including yeast histone deacetylase and acetoin utilization protein
HIMB5_RS06095	COG0101	tRNA pseudouridine synthase activity
HIMB5_RS06100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HIMB5_RS06105	COG0242	peptide deformylase activity
HIMB5_RS06120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HIMB5_RS06125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HIMB5_RS06155	COG0187	DNA topoisomerase II activity
HIMB5_RS06175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIMB5_RS06205	COG0481	GTPase activity
HIMB5_RS06210	COG0072	phenylalanine-tRNA ligase activity
HIMB5_RS06215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HIMB5_RS06220	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HIMB5_RS06225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HIMB5_RS06230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HIMB5_RS06235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HIMB5_RS06260	COG1968	undecaprenyl-diphosphatase activity
HIMB5_RS06265	COG0697	spore germination
HIMB5_RS06270	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIMB5_RS06305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HIMB5_RS06325	COG1238	metal cluster binding
HIMB5_RS06335	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HIMB5_RS06360	COG0165	Argininosuccinate lyase
HIMB5_RS06365	COG0019	diaminopimelate decarboxylase activity
HIMB5_RS06370	COG0204	Acyl-transferase
HIMB5_RS06380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HIMB5_RS06385	COG0268	Binds directly to 16S ribosomal RNA
HIMB5_RS06390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HIMB5_RS06395	COG2226	methyltransferase
HIMB5_RS06400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HIMB5_RS06405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIMB5_RS06410	COG0756	dUTP diphosphatase activity
HIMB5_RS06415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HIMB5_RS06435	COG1592	Rubrerythrin
HIMB5_RS06445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HIMB5_RS06455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HIMB5_RS06475	COG1185	polyribonucleotide nucleotidyltransferase activity
HIMB5_RS06480	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HIMB5_RS06485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HIMB5_RS06490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HIMB5_RS06500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HIMB5_RS06505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HIMB5_RS06510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HIMB5_RS06515	COG1702	phosphate starvation-inducible protein PhoH
HIMB5_RS06520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HIMB5_RS06545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HIMB5_RS06550	COG0180	Tryptophanyl-tRNA synthetase
HIMB5_RS06560	COG0280	phosphate acetyltransferase
HIMB5_RS06560	COG0281	malic enzyme
HIMB5_RS06570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HIMB5_RS06580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HIMB5_RS06585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HIMB5_RS06590	COG0443	Heat shock 70 kDa protein
HIMB5_RS06595	COG0484	heat shock protein binding
HIMB5_RS06600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HIMB5_RS06605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIMB5_RS06610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIMB5_RS06625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HIMB5_RS06670	COG0357	Ribosomal RNA small subunit methyltransferase G
HIMB5_RS06675	COG0445	tRNA wobble uridine modification
HIMB5_RS06680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HIMB5_RS06685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HIMB5_RS06690	COG1981	membrane
HIMB5_RS06695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HIMB5_RS06705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HIMB5_RS06710	COG0424	maF-like protein
HIMB5_RS06715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HIMB5_RS06730	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HIMB5_RS06755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HIMB5_RS06760	COG0131	Imidazoleglycerol-phosphate dehydratase
HIMB5_RS06765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HIMB5_RS06770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HIMB5_RS06775	COG0107	imidazoleglycerol-phosphate synthase activity
HIMB5_RS06780	COG0140	phosphoribosyl-ATP diphosphatase activity
HIMB5_RS06780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIMB5_RS06800	COG1674	ftsk spoiiie
HIMB5_RS06805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIMB5_RS06810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HIMB5_RS06820	COG2154	pterin-4-alpha-carbinolamine dehydratase
HIMB5_RS06825	COG0138	bifunctional purine biosynthesis protein purh
HIMB5_RS06835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIMB5_RS06845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIMB5_RS06860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIMB5_RS06875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HIMB5_RS06880	COG0181	hydroxymethylbilane synthase activity
HIMB5_RS06890	COG0668	transmembrane transport
HIMB5_RS06900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HIMB5_RS06920	COG2133	pyrroloquinoline quinone binding
HIMB5_RS06930	COG3046	protein related to deoxyribodipyrimidine photolyase
HIMB5_RS06960	COG0505	Belongs to the CarA family
HIMB5_RS06980	COG0137	argininosuccinate synthase activity
HIMB5_RS06990	COG0667	Aldo Keto reductase
HIMB5_RS06995	COG0670	Belongs to the BI1 family
HIMB5_RS07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIMB5_RS07005	COG2917	probably involved in intracellular septation
HIMB5_RS07015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HIMB5_RS07025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HIMB5_RS07030	COG1138	Cytochrome C-type biogenesis protein
HIMB5_RS07035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HIMB5_RS07040	COG3088	subunit of a heme lyase
HIMB5_RS07050	COG1304	FMN binding
HIMB5_RS07055	COG0436	Aminotransferase
HIMB5_RS07060	COG0277	FAD linked oxidase domain protein
HIMB5_RS07065	COG0277	FAD linked oxidase domain protein
HIMB5_RS07070	COG0247	lactate metabolic process
HIMB5_RS07080	COG2814	Major facilitator Superfamily
HIMB5_RS07090	COG1063	alcohol dehydrogenase
HIMB5_RS07100	COG1175	transmembrane transport
HIMB5_RS07105	COG0395	ABC-type sugar transport system, permease component
HIMB5_RS07110	COG3842	ATPase activity
HIMB5_RS07115	COG3842	ATPase activity
HIMB5_RS07140	COG0154	amidase activity
HIMB5_RS07150	COG0697	spore germination
HIMB5_RS07160	COG0552	protein localization to endoplasmic reticulum
HIMB5_RS07165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HIMB5_RS07170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIMB5_RS07175	COG0228	four-way junction DNA binding
HIMB5_RS07205	COG2133	pyrroloquinoline quinone binding
HIMB5_RS07235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus