locus-tag	class	description
DSAG12_RS00015	COG0436	Aminotransferase
DSAG12_RS00030	COG0071	Belongs to the small heat shock protein (HSP20) family
DSAG12_RS00055	COG2986	histidine ammonia-lyase
DSAG12_RS00060	COG1228	amidohydrolase
DSAG12_RS00065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DSAG12_RS00095	COG2226	methyltransferase
DSAG12_RS00120	COG1606	tRNA processing
DSAG12_RS00165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSAG12_RS00195	COG2255	four-way junction helicase activity
DSAG12_RS00220	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS00230	COG1086	Polysaccharide biosynthesis protein
DSAG12_RS00245	COG1073	alpha beta
DSAG12_RS00250	COG0673	inositol 2-dehydrogenase activity
DSAG12_RS00260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSAG12_RS00260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSAG12_RS00285	COG0456	acetyltransferase
DSAG12_RS00315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSAG12_RS00355	COG0655	NAD(P)H dehydrogenase (quinone) activity
DSAG12_RS00365	COG0148	phosphopyruvate hydratase activity
DSAG12_RS00395	COG1960	acyl-CoA dehydrogenase activity
DSAG12_RS00400	COG2030	dehydratase
DSAG12_RS00410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DSAG12_RS00475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSAG12_RS00525	COG2226	methyltransferase
DSAG12_RS00540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DSAG12_RS00570	COG0430	RNA-3'-phosphate cyclase activity
DSAG12_RS00575	COG1058	Belongs to the CinA family
DSAG12_RS00575	COG1546	Belongs to the CinA family
DSAG12_RS00580	COG1056	cytidyltransferase-related domain
DSAG12_RS00580	COG1051	belongs to the nudix hydrolase family
DSAG12_RS00625	COG0525	valine-tRNA ligase activity
DSAG12_RS00635	COG2267	carboxylic ester hydrolase activity
DSAG12_RS00650	COG0037	tRNA processing
DSAG12_RS00655	COG1042	CoA-binding domain protein
DSAG12_RS00655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSAG12_RS00655	COG0045	succinate-CoA ligase (ADP-forming) activity
DSAG12_RS00670	COG3848	Pyruvate phosphate dikinase
DSAG12_RS00670	COG0574	Belongs to the PEP-utilizing enzyme family
DSAG12_RS00695	COG0495	leucyl-tRNA aminoacylation
DSAG12_RS00720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSAG12_RS00750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSAG12_RS00755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSAG12_RS00760	COG0427	acetyl-CoA hydrolase
DSAG12_RS00770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSAG12_RS00775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSAG12_RS00795	COG0312	modulator of DNA gyrase
DSAG12_RS00800	COG0045	succinate-CoA ligase (ADP-forming) activity
DSAG12_RS00800	COG1042	CoA-binding domain protein
DSAG12_RS00800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSAG12_RS00805	COG0857	belongs to the CobB CobQ family
DSAG12_RS00820	COG0826	peptidase U32
DSAG12_RS00850	COG0822	iron-sulfur transferase activity
DSAG12_RS00865	COG1136	(ABC) transporter
DSAG12_RS00890	COG0546	phosphoglycolate phosphatase activity
DSAG12_RS00910	COG1136	(ABC) transporter
DSAG12_RS00935	COG0006	proline dipeptidase activity
DSAG12_RS00950	COG1342	Belongs to the UPF0251 family
DSAG12_RS00960	COG1522	sequence-specific DNA binding
DSAG12_RS00975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSAG12_RS01000	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS01045	COG0640	Transcriptional regulator
DSAG12_RS01090	COG0596	Alpha beta hydrolase
DSAG12_RS01130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DSAG12_RS01200	COG4555	ABC transporter
DSAG12_RS01235	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS01240	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS01245	COG1144	Oxidoreductase
DSAG12_RS01310	COG0519	Catalyzes the synthesis of GMP from XMP
DSAG12_RS01310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSAG12_RS01315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSAG12_RS01330	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DSAG12_RS01340	COG1122	ATPase activity
DSAG12_RS01365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DSAG12_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS01400	COG0167	dihydroorotate dehydrogenase activity
DSAG12_RS01440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSAG12_RS01450	COG1205	dead DEAH box helicase
DSAG12_RS01450	COG1111	helicase
DSAG12_RS01485	COG2815	serine threonine protein kinase
DSAG12_RS01485	COG0515	serine threonine protein kinase
DSAG12_RS01505	COG0596	Alpha beta hydrolase
DSAG12_RS01530	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DSAG12_RS01600	COG0596	Alpha beta hydrolase
DSAG12_RS01620	COG0252	asparaginase activity
DSAG12_RS01625	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSAG12_RS01660	COG2414	aldehyde ferredoxin oxidoreductase
DSAG12_RS01665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DSAG12_RS01670	COG0252	asparaginase activity
DSAG12_RS01720	COG0464	growth
DSAG12_RS01740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DSAG12_RS01765	COG4166	transmembrane transport
DSAG12_RS01785	COG1132	(ABC) transporter
DSAG12_RS01790	COG1132	(ABC) transporter
DSAG12_RS01860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DSAG12_RS01880	COG0085	RNA polymerase activity
DSAG12_RS01895	COG1335	isochorismatase
DSAG12_RS01900	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DSAG12_RS01935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSAG12_RS01960	COG0640	Transcriptional regulator
DSAG12_RS01975	COG2226	methyltransferase
DSAG12_RS01990	COG1131	(ABC) transporter
DSAG12_RS02000	COG0604	alcohol dehydrogenase
DSAG12_RS02060	COG0455	bacterial-type flagellum organization
DSAG12_RS02065	COG0489	protein tyrosine kinase activity
DSAG12_RS02170	COG1085	galactose-1-phosphate uridylyltransferase
DSAG12_RS02180	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS02215	COG1924	4 iron, 4 sulfur cluster binding
DSAG12_RS02220	COG0714	Associated with various cellular activities
DSAG12_RS02245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DSAG12_RS02250	COG1144	Oxidoreductase
DSAG12_RS02255	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS02260	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS02290	COG1215	transferase activity, transferring glycosyl groups
DSAG12_RS02295	COG0646	methionine synthase
DSAG12_RS02295	COG1410	methionine synthase
DSAG12_RS02305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSAG12_RS02310	COG1607	acyl-coa hydrolase
DSAG12_RS02315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSAG12_RS02335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSAG12_RS02345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSAG12_RS02350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DSAG12_RS02390	COG0436	Aminotransferase
DSAG12_RS02400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DSAG12_RS02440	COG1640	4-alpha-glucanotransferase
DSAG12_RS02450	COG1196	nuclear chromosome segregation
DSAG12_RS02450	COG1196	nuclear chromosome segregation
DSAG12_RS02475	COG1278	Cold shock
DSAG12_RS02510	COG1362	aminopeptidase activity
DSAG12_RS02525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSAG12_RS02525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSAG12_RS02535	COG0531	amino acid
DSAG12_RS02555	COG0481	GTPase activity
DSAG12_RS02635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DSAG12_RS02640	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DSAG12_RS02680	COG1185	polyribonucleotide nucleotidyltransferase activity
DSAG12_RS02710	COG0456	acetyltransferase
DSAG12_RS02730	COG0308	aminopeptidase N
DSAG12_RS02740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DSAG12_RS02745	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSAG12_RS02750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DSAG12_RS02755	COG1193	negative regulation of DNA recombination
DSAG12_RS02770	COG0604	alcohol dehydrogenase
DSAG12_RS02815	COG1760	l-serine dehydratase
DSAG12_RS02820	COG1760	l-serine dehydratase
DSAG12_RS02825	COG3246	L-lysine catabolic process to acetate
DSAG12_RS02830	COG1607	acyl-coa hydrolase
DSAG12_RS02850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSAG12_RS02875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DSAG12_RS02885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSAG12_RS02925	COG0023	Translation Initiation Factor
DSAG12_RS02930	COG1078	dGTPase activity
DSAG12_RS02965	COG0528	UMP kinase activity
DSAG12_RS03055	COG1078	dGTPase activity
DSAG12_RS03095	COG1794	racemase activity, acting on amino acids and derivatives
DSAG12_RS03195	COG1694	Mazg nucleotide pyrophosphohydrolase
DSAG12_RS03210	COG0438	transferase activity, transferring glycosyl groups
DSAG12_RS03220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSAG12_RS03265	COG0037	tRNA processing
DSAG12_RS03280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSAG12_RS03285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSAG12_RS03290	COG0301	tRNA thio-modification
DSAG12_RS03325	COG0459	protein refolding
DSAG12_RS03360	COG1100	Small GTP-binding protein
DSAG12_RS03440	COG0089	rRNA binding
DSAG12_RS03455	COG3842	ATPase activity
DSAG12_RS03470	COG1404	Belongs to the peptidase S8 family
DSAG12_RS03535	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DSAG12_RS03555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DSAG12_RS03560	COG0537	adenosine 5'-monophosphoramidase activity
DSAG12_RS03580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSAG12_RS03625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSAG12_RS03630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DSAG12_RS03640	COG0288	reversible hydration of carbon dioxide
DSAG12_RS03645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DSAG12_RS03660	COG3842	ATPase activity
DSAG12_RS03665	COG3842	ATPase activity
DSAG12_RS03750	COG0515	serine threonine protein kinase
DSAG12_RS03750	COG2815	serine threonine protein kinase
DSAG12_RS03770	COG0343	queuine tRNA-ribosyltransferase activity
DSAG12_RS03825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSAG12_RS03830	COG1011	Hydrolase
DSAG12_RS03840	COG1260	myo-inositol-1-phosphate synthase
DSAG12_RS03890	COG2030	dehydratase
DSAG12_RS03895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DSAG12_RS03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSAG12_RS03910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSAG12_RS03920	COG0009	L-threonylcarbamoyladenylate synthase
DSAG12_RS03955	COG2814	Major facilitator Superfamily
DSAG12_RS03995	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS04000	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSAG12_RS04055	COG1196	nuclear chromosome segregation
DSAG12_RS04055	COG1196	nuclear chromosome segregation
DSAG12_RS04135	COG2211	Major facilitator Superfamily
DSAG12_RS04175	COG0647	UMP catabolic process
DSAG12_RS04180	COG0243	molybdopterin cofactor binding
DSAG12_RS04225	COG1011	Hydrolase
DSAG12_RS04245	COG1924	4 iron, 4 sulfur cluster binding
DSAG12_RS04280	COG2084	Dehydrogenase
DSAG12_RS04285	COG2814	Major facilitator Superfamily
DSAG12_RS04300	COG0300	oxidoreductase activity
DSAG12_RS04315	COG1121	(ABC) transporter
DSAG12_RS04320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSAG12_RS04330	COG1321	iron dependent repressor
DSAG12_RS04345	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DSAG12_RS04345	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DSAG12_RS04365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSAG12_RS04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSAG12_RS04370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSAG12_RS04375	COG0396	ATPase activity
DSAG12_RS04380	COG0719	Fe-S assembly protein
DSAG12_RS04415	COG1363	Peptidase, m42
DSAG12_RS04455	COG0037	tRNA processing
DSAG12_RS04470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSAG12_RS04485	COG0322	excinuclease ABC activity
DSAG12_RS04495	COG2211	Major facilitator Superfamily
DSAG12_RS04495	COG2190	(PTS) system
DSAG12_RS04500	COG0006	proline dipeptidase activity
DSAG12_RS04530	COG0432	Pfam Uncharacterised protein family UPF0047
DSAG12_RS04535	COG0180	Tryptophanyl-tRNA synthetase
DSAG12_RS04555	COG4279	zinc finger
DSAG12_RS04560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSAG12_RS04575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSAG12_RS04670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DSAG12_RS04675	COG0489	protein tyrosine kinase activity
DSAG12_RS04705	COG0584	glycerophosphoryl diester phosphodiesterase
DSAG12_RS04735	COG5277	cytoskeleton organization
DSAG12_RS04765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DSAG12_RS04800	COG0424	maF-like protein
DSAG12_RS04810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSAG12_RS04820	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DSAG12_RS04855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSAG12_RS04885	COG0546	phosphoglycolate phosphatase activity
DSAG12_RS04900	COG1872	DUF167
DSAG12_RS04945	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS04990	COG0667	Aldo Keto reductase
DSAG12_RS05085	COG2226	methyltransferase
DSAG12_RS05115	COG0366	Alpha amylase catalytic
DSAG12_RS05160	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS05180	COG0017	Asparaginyl-tRNA synthetase
DSAG12_RS05200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSAG12_RS05210	COG2814	Major facilitator Superfamily
DSAG12_RS05280	COG0215	cysteine-tRNA ligase activity
DSAG12_RS05305	COG2270	Major facilitator Superfamily
DSAG12_RS05325	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DSAG12_RS05330	COG2217	Heavy metal translocating P-type atpase
DSAG12_RS05350	COG1131	(ABC) transporter
DSAG12_RS05355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DSAG12_RS05360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSAG12_RS05365	COG1846	Transcriptional regulator
DSAG12_RS05370	COG1136	(ABC) transporter
DSAG12_RS05380	COG0028	Belongs to the TPP enzyme family
DSAG12_RS05420	COG0822	iron-sulfur transferase activity
DSAG12_RS05480	COG1592	Rubrerythrin
DSAG12_RS05485	COG2033	superoxide reductase activity
DSAG12_RS05505	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS05535	COG1331	Highly conserved protein containing a thioredoxin domain
DSAG12_RS05555	COG1960	acyl-CoA dehydrogenase activity
DSAG12_RS05585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSAG12_RS05585	COG0426	domain, Protein
DSAG12_RS05600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DSAG12_RS05615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSAG12_RS05630	COG2048	Heterodisulfide reductase, subunit B
DSAG12_RS05635	COG2181	nitrate reductase activity
DSAG12_RS05635	COG0247	lactate metabolic process
DSAG12_RS05640	COG0425	Belongs to the sulfur carrier protein TusA family
DSAG12_RS05660	COG2210	Belongs to the sulfur carrier protein TusA family
DSAG12_RS05675	COG2048	Heterodisulfide reductase, subunit B
DSAG12_RS05730	COG0473	3-isopropylmalate dehydrogenase activity
DSAG12_RS05745	COG2048	Heterodisulfide reductase, subunit B
DSAG12_RS05785	COG0200	Binds to the 23S rRNA
DSAG12_RS05815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSAG12_RS05820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSAG12_RS05830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSAG12_RS05845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSAG12_RS05850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSAG12_RS05860	COG0255	Belongs to the universal ribosomal protein uL29 family
DSAG12_RS05865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSAG12_RS05875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSAG12_RS05930	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DSAG12_RS05955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DSAG12_RS05960	COG0501	Belongs to the peptidase M48B family
DSAG12_RS05965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSAG12_RS05980	COG1304	FMN binding
DSAG12_RS05990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DSAG12_RS06005	COG3425	synthase
DSAG12_RS06010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSAG12_RS06025	COG2030	dehydratase
DSAG12_RS06030	COG0110	maltose O-acetyltransferase activity
DSAG12_RS06060	COG1454	alcohol dehydrogenase
DSAG12_RS06060	COG1012	belongs to the aldehyde dehydrogenase family
DSAG12_RS06075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSAG12_RS06080	COG2267	carboxylic ester hydrolase activity
DSAG12_RS06175	COG1850	ribulose-bisphosphate carboxylase activity
DSAG12_RS06180	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DSAG12_RS06185	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSAG12_RS06195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DSAG12_RS06200	COG0459	protein refolding
DSAG12_RS06240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSAG12_RS06245	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSAG12_RS06265	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DSAG12_RS06275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSAG12_RS06275	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DSAG12_RS06300	COG1131	(ABC) transporter
DSAG12_RS06320	COG1418	mRNA catabolic process
DSAG12_RS06365	COG1047	Peptidyl-prolyl cis-trans
DSAG12_RS06370	COG0561	phosphatase activity
DSAG12_RS06380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSAG12_RS06405	COG1024	Enoyl-CoA hydratase
DSAG12_RS06410	COG1960	acyl-CoA dehydrogenase activity
DSAG12_RS06415	COG2211	Major facilitator Superfamily
DSAG12_RS06430	COG0492	ferredoxin-NADP+ reductase activity
DSAG12_RS06440	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS06445	COG1404	Belongs to the peptidase S8 family
DSAG12_RS06455	COG0649	NAD binding
DSAG12_RS06470	COG0756	dUTP diphosphatase activity
DSAG12_RS06480	COG1104	cysteine desulfurase activity
DSAG12_RS06485	COG0018	arginyl-trna synthetase
DSAG12_RS06490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DSAG12_RS06505	COG0442	prolyl-tRNA aminoacylation
DSAG12_RS06530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DSAG12_RS06545	COG1960	acyl-CoA dehydrogenase activity
DSAG12_RS06565	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DSAG12_RS06585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSAG12_RS06590	COG2204	response regulator
DSAG12_RS06595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSAG12_RS06595	COG4191	Histidine kinase
DSAG12_RS06610	COG0827	DNA restriction-modification system
DSAG12_RS06635	COG0697	spore germination
DSAG12_RS06650	COG0731	radical SAM domain protein
DSAG12_RS06650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSAG12_RS06655	COG2211	Major facilitator Superfamily
DSAG12_RS06670	COG2211	Major facilitator Superfamily
DSAG12_RS06690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSAG12_RS06710	COG0745	RESPONSE REGULATOR receiver
DSAG12_RS06755	COG1363	Peptidase, m42
DSAG12_RS06810	COG0300	oxidoreductase activity
DSAG12_RS06815	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSAG12_RS06830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DSAG12_RS06850	COG1234	tRNA 3'-trailer cleavage
DSAG12_RS06875	COG0384	phenazine biosynthesis protein PhzF
DSAG12_RS06965	COG0515	serine threonine protein kinase
DSAG12_RS06965	COG4991	sh3 domain protein
DSAG12_RS06965	COG3064	Membrane
DSAG12_RS06975	COG0436	Aminotransferase
DSAG12_RS06985	COG0460	homoserine dehydrogenase
DSAG12_RS07005	COG0708	Exodeoxyribonuclease III
DSAG12_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS07060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSAG12_RS07070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DSAG12_RS07105	COG1378	Sugar-specific transcriptional regulator TrmB
DSAG12_RS07110	COG0709	Synthesizes selenophosphate from selenide and ATP
DSAG12_RS07140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSAG12_RS07240	COG2267	carboxylic ester hydrolase activity
DSAG12_RS07260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DSAG12_RS07260	COG0519	Catalyzes the synthesis of GMP from XMP
DSAG12_RS07285	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSAG12_RS07310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSAG12_RS07350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSAG12_RS07365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSAG12_RS07400	COG1132	(ABC) transporter
DSAG12_RS07440	COG1543	Belongs to the glycosyl hydrolase 57 family
DSAG12_RS07445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSAG12_RS07450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSAG12_RS07500	COG2078	PFAM AMMECR1 domain protein
DSAG12_RS07510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSAG12_RS07540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DSAG12_RS07555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DSAG12_RS07565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSAG12_RS07570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSAG12_RS07600	COG0519	Catalyzes the synthesis of GMP from XMP
DSAG12_RS07650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSAG12_RS07655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSAG12_RS07670	COG0312	modulator of DNA gyrase
DSAG12_RS07675	COG0312	modulator of DNA gyrase
DSAG12_RS07690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS07745	COG1132	(ABC) transporter
DSAG12_RS07775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSAG12_RS07840	COG0601	transmembrane transport
DSAG12_RS07845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSAG12_RS07865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSAG12_RS07885	COG0202	RNA polymerase activity
DSAG12_RS07900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSAG12_RS07905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSAG12_RS07910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSAG12_RS07950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DSAG12_RS07995	COG1615	UPF0182 protein
DSAG12_RS08015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DSAG12_RS08020	COG2226	methyltransferase
DSAG12_RS08025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSAG12_RS08035	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
DSAG12_RS08035	COG0028	Belongs to the TPP enzyme family
DSAG12_RS08055	COG0459	protein refolding
DSAG12_RS08070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSAG12_RS08085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DSAG12_RS08115	COG2962	Rard protein
DSAG12_RS08135	COG1918	ferrous iron import across plasma membrane
DSAG12_RS08135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DSAG12_RS08145	COG3360	Dodecin
DSAG12_RS08160	COG1472	Belongs to the glycosyl hydrolase 3 family
DSAG12_RS08170	COG1122	ATPase activity
DSAG12_RS08185	COG0310	cobalt ion transport
DSAG12_RS08210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSAG12_RS08220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DSAG12_RS08225	COG2252	PERMEase
DSAG12_RS08355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSAG12_RS08390	COG1269	ATP hydrolysis coupled proton transport
DSAG12_RS08395	COG1394	ATPase activity, coupled to movement of substances
DSAG12_RS08400	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DSAG12_RS08505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSAG12_RS08510	COG2211	Major facilitator Superfamily
DSAG12_RS08525	COG0463	Glycosyl transferase, family 2
DSAG12_RS08530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DSAG12_RS08550	COG2211	Major facilitator Superfamily
DSAG12_RS08590	COG1136	(ABC) transporter
DSAG12_RS08605	COG0281	malic enzyme
DSAG12_RS08615	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSAG12_RS08625	COG1473	amidohydrolase
DSAG12_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS08655	COG0584	glycerophosphoryl diester phosphodiesterase
DSAG12_RS08715	COG3875	lactate racemase activity
DSAG12_RS08740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSAG12_RS08740	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSAG12_RS08775	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DSAG12_RS08840	COG1304	FMN binding
DSAG12_RS08850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSAG12_RS08855	COG0081	regulation of translation
DSAG12_RS08965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSAG12_RS08970	COG0052	Belongs to the universal ribosomal protein uS2 family
DSAG12_RS09005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DSAG12_RS09020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DSAG12_RS09020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DSAG12_RS09035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSAG12_RS09085	COG0438	transferase activity, transferring glycosyl groups
DSAG12_RS09090	COG0662	Cupin 2, conserved barrel domain protein
DSAG12_RS09090	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DSAG12_RS09100	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DSAG12_RS09105	COG1091	dTDP-4-dehydrorhamnose reductase activity
DSAG12_RS09115	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DSAG12_RS09155	COG0463	Glycosyl transferase, family 2
DSAG12_RS09160	COG3594	Acyltransferase
DSAG12_RS09165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSAG12_RS09170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS09205	COG2089	acid synthase
DSAG12_RS09210	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DSAG12_RS09215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSAG12_RS09225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSAG12_RS09230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSAG12_RS09235	COG1086	Polysaccharide biosynthesis protein
DSAG12_RS09245	COG1216	Glycosyl transferase, family 2
DSAG12_RS09250	COG0463	Glycosyl transferase, family 2
DSAG12_RS09295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS09300	COG1088	dTDP-glucose 4,6-dehydratase activity
DSAG12_RS09305	COG0438	transferase activity, transferring glycosyl groups
DSAG12_RS09330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS09345	COG0495	leucyl-tRNA aminoacylation
DSAG12_RS09355	COG2244	polysaccharide biosynthetic process
DSAG12_RS09380	COG1215	transferase activity, transferring glycosyl groups
DSAG12_RS09390	COG4750	Nucleotidyl transferase
DSAG12_RS09400	COG0494	nUDIX hydrolase
DSAG12_RS09420	COG0535	radical SAM domain protein
DSAG12_RS09435	COG1136	(ABC) transporter
DSAG12_RS09460	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DSAG12_RS09490	COG2314	TM2 domain
DSAG12_RS09495	COG0500	methyltransferase
DSAG12_RS09500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSAG12_RS09515	COG1250	3-hydroxyacyl-CoA dehydrogenase
DSAG12_RS09525	COG0126	phosphoglycerate kinase activity
DSAG12_RS09530	COG2183	response to ionizing radiation
DSAG12_RS09535	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DSAG12_RS09535	COG0316	Belongs to the HesB IscA family
DSAG12_RS09595	COG1691	(AIR) carboxylase
DSAG12_RS09620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSAG12_RS09625	COG0427	acetyl-CoA hydrolase
DSAG12_RS09685	COG0546	phosphoglycolate phosphatase activity
DSAG12_RS09690	COG0123	including yeast histone deacetylase and acetoin utilization protein
DSAG12_RS09785	COG0604	alcohol dehydrogenase
DSAG12_RS09805	COG0123	including yeast histone deacetylase and acetoin utilization protein
DSAG12_RS09825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSAG12_RS09875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DSAG12_RS09880	COG2211	Major facilitator Superfamily
DSAG12_RS09910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSAG12_RS09915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSAG12_RS09935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DSAG12_RS09950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSAG12_RS09995	COG0028	Belongs to the TPP enzyme family
DSAG12_RS10005	COG0129	dihydroxy-acid dehydratase activity
DSAG12_RS10015	COG2211	Major facilitator Superfamily
DSAG12_RS10100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSAG12_RS10125	COG0714	Associated with various cellular activities
DSAG12_RS10180	COG1022	Amp-dependent synthetase and ligase
DSAG12_RS10185	COG1022	Amp-dependent synthetase and ligase
DSAG12_RS10195	COG1045	serine acetyltransferase
DSAG12_RS10210	COG0095	Lipoate-protein ligase
DSAG12_RS10245	COG0312	modulator of DNA gyrase
DSAG12_RS10265	COG3118	belongs to the thioredoxin family
DSAG12_RS10285	COG0149	triose-phosphate isomerase activity
DSAG12_RS10310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSAG12_RS10345	COG1199	ATP-dependent helicase activity
DSAG12_RS10355	COG0438	transferase activity, transferring glycosyl groups
DSAG12_RS10375	COG1228	amidohydrolase
DSAG12_RS10465	COG1132	(ABC) transporter
DSAG12_RS10470	COG1132	(ABC) transporter
DSAG12_RS10515	COG2890	protein-(glutamine-N5) methyltransferase activity
DSAG12_RS10660	COG1100	Small GTP-binding protein
DSAG12_RS10760	COG0513	Belongs to the DEAD box helicase family
DSAG12_RS10815	COG0017	Asparaginyl-tRNA synthetase
DSAG12_RS10820	COG0585	pseudouridine synthase activity
DSAG12_RS10825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSAG12_RS10830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DSAG12_RS10835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSAG12_RS10845	COG0215	cysteine-tRNA ligase activity
DSAG12_RS10850	COG0604	alcohol dehydrogenase
DSAG12_RS10880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSAG12_RS10885	COG0047	phosphoribosylformylglycinamidine synthase activity
DSAG12_RS10890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSAG12_RS10910	COG2267	carboxylic ester hydrolase activity
DSAG12_RS10925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSAG12_RS10930	COG0187	DNA topoisomerase II activity
DSAG12_RS10935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSAG12_RS10990	COG4895	conserved protein (DUF2196)
DSAG12_RS11035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DSAG12_RS11035	COG1605	Chorismate mutase
DSAG12_RS11040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DSAG12_RS11050	COG0017	Asparaginyl-tRNA synthetase
DSAG12_RS11055	COG3604	Transcriptional regulator
DSAG12_RS11070	COG4335	DNA alkylation repair
DSAG12_RS11085	COG1793	dna ligase
DSAG12_RS11090	COG1899	peptidyl-lysine modification to peptidyl-hypusine
DSAG12_RS11095	COG1945	arginine decarboxylase activity
DSAG12_RS11110	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSAG12_RS11115	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSAG12_RS11195	COG1136	(ABC) transporter
DSAG12_RS11200	COG1122	ATPase activity
DSAG12_RS11325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSAG12_RS11370	COG0151	Belongs to the GarS family
DSAG12_RS11385	COG0492	ferredoxin-NADP+ reductase activity
DSAG12_RS11400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSAG12_RS11440	COG1305	Transglutaminase-like
DSAG12_RS11490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSAG12_RS11510	COG1193	negative regulation of DNA recombination
DSAG12_RS11530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSAG12_RS11540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSAG12_RS11560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSAG12_RS11565	COG3345	alpha-galactosidase
DSAG12_RS11580	COG0671	phosphoesterase, PA-phosphatase related
DSAG12_RS11585	COG0183	Belongs to the thiolase family
DSAG12_RS11595	COG1136	(ABC) transporter
DSAG12_RS11605	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSAG12_RS11605	COG1902	pentaerythritol trinitrate reductase activity
DSAG12_RS11630	COG1160	GTP binding
DSAG12_RS11635	COG3250	beta-galactosidase activity
DSAG12_RS11690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSAG12_RS11715	COG2234	aminopeptidase activity
DSAG12_RS11720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSAG12_RS11730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSAG12_RS11825	COG0306	phosphate transporter
DSAG12_RS11835	COG0516	GMP reductase activity
DSAG12_RS11835	COG0517	IMP dehydrogenase activity
DSAG12_RS11915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSAG12_RS11965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSAG12_RS11970	COG1741	Belongs to the pirin family
DSAG12_RS11990	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
DSAG12_RS12035	COG2442	InterPro IPR007367
DSAG12_RS12045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSAG12_RS12070	COG0561	phosphatase activity
DSAG12_RS12100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSAG12_RS12105	COG2205	protein histidine kinase activity
DSAG12_RS12105	COG5002	protein histidine kinase activity
DSAG12_RS12105	COG0784	Response regulator, receiver
DSAG12_RS12115	COG0745	RESPONSE REGULATOR receiver
DSAG12_RS12130	COG0643	Histidine kinase
DSAG12_RS12130	COG0784	Response regulator, receiver
DSAG12_RS12130	COG2198	Histidine kinase
DSAG12_RS12140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSAG12_RS12145	COG2205	protein histidine kinase activity
DSAG12_RS12175	COG2202	Pas domain
DSAG12_RS12175	COG2205	protein histidine kinase activity
DSAG12_RS12180	COG4172	Belongs to the ABC transporter superfamily
DSAG12_RS12220	COG0045	succinate-CoA ligase (ADP-forming) activity
DSAG12_RS12225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSAG12_RS12240	COG1047	Peptidyl-prolyl cis-trans
DSAG12_RS12250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DSAG12_RS12330	COG0551	DNA topoisomerase type I activity
DSAG12_RS12330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSAG12_RS12370	COG0673	inositol 2-dehydrogenase activity
DSAG12_RS12395	COG1703	isobutyryl-CoA mutase activity
DSAG12_RS12400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSAG12_RS12400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSAG12_RS12405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSAG12_RS12405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DSAG12_RS12435	COG0300	oxidoreductase activity
DSAG12_RS12485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSAG12_RS12490	COG0483	inositol monophosphate 1-phosphatase activity
DSAG12_RS12550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS12555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSAG12_RS12555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSAG12_RS12570	COG3250	beta-galactosidase activity
DSAG12_RS12730	COG2205	protein histidine kinase activity
DSAG12_RS12825	COG3384	dioxygenase
DSAG12_RS12840	COG0456	acetyltransferase
DSAG12_RS12850	COG1136	(ABC) transporter
DSAG12_RS12860	COG1136	(ABC) transporter
DSAG12_RS12920	COG1100	Small GTP-binding protein
DSAG12_RS12940	COG1070	Carbohydrate kinase
DSAG12_RS12945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSAG12_RS13045	COG1061	Type III restriction enzyme res subunit
DSAG12_RS13250	COG2211	Major facilitator Superfamily
DSAG12_RS13270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSAG12_RS13375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DSAG12_RS13380	COG1882	Formate acetyltransferase
DSAG12_RS13410	COG3844	kynureninase activity
DSAG12_RS13425	COG0826	peptidase U32
DSAG12_RS13435	COG1132	(ABC) transporter
DSAG12_RS13460	COG0656	L-ascorbic acid biosynthetic process
DSAG12_RS13495	COG2226	methyltransferase
DSAG12_RS13535	COG0010	Belongs to the arginase family
DSAG12_RS13540	COG1899	peptidyl-lysine modification to peptidyl-hypusine
DSAG12_RS13545	COG0667	Aldo Keto reductase
DSAG12_RS13550	COG0716	FMN binding
DSAG12_RS13605	COG0051	transcription antitermination factor activity, RNA binding
DSAG12_RS13610	COG2813	Specifically methylates the guanine in position
DSAG12_RS13645	COG0306	phosphate transporter
DSAG12_RS13680	COG0156	8-amino-7-oxononanoate synthase activity
DSAG12_RS13685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS13715	COG0006	proline dipeptidase activity
DSAG12_RS13735	COG0398	Pfam SNARE associated Golgi protein
DSAG12_RS13760	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSAG12_RS13765	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
DSAG12_RS13785	COG2373	Large extracellular alpha-helical protein
DSAG12_RS13860	COG0437	4 iron, 4 sulfur cluster binding
DSAG12_RS13865	COG2414	aldehyde ferredoxin oxidoreductase
DSAG12_RS13885	COG2181	nitrate reductase activity
DSAG12_RS13885	COG0247	lactate metabolic process
DSAG12_RS13895	COG2878	Part of a membrane complex involved in electron transport
DSAG12_RS13910	COG0656	L-ascorbic acid biosynthetic process
DSAG12_RS13940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSAG12_RS13940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSAG12_RS13980	COG2169	Transcriptional regulator
DSAG12_RS13995	COG0668	transmembrane transport
DSAG12_RS14010	COG2084	Dehydrogenase
DSAG12_RS14030	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSAG12_RS14040	COG4974	Belongs to the 'phage' integrase family
DSAG12_RS14065	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DSAG12_RS14105	COG1132	(ABC) transporter
DSAG12_RS14110	COG1132	(ABC) transporter
DSAG12_RS14165	COG0697	spore germination
DSAG12_RS14170	COG2223	nitrite transmembrane transporter activity
DSAG12_RS14195	COG2211	Major facilitator Superfamily
DSAG12_RS14200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSAG12_RS14235	COG1396	sequence-specific DNA binding
DSAG12_RS14250	COG4152	abc transporter atp-binding protein
DSAG12_RS14290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSAG12_RS14300	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSAG12_RS14300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DSAG12_RS14385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DSAG12_RS14385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSAG12_RS14400	COG3291	Pkd domain containing protein
DSAG12_RS14445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSAG12_RS14455	COG1122	ATPase activity
DSAG12_RS14470	COG0588	phosphoglycerate mutase activity
DSAG12_RS14475	COG0588	phosphoglycerate mutase activity
DSAG12_RS14560	COG0191	fructose-bisphosphate aldolase activity
DSAG12_RS14565	COG0517	IMP dehydrogenase activity
DSAG12_RS14565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSAG12_RS14570	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSAG12_RS14610	COG0277	FAD linked oxidase domain protein
DSAG12_RS14620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSAG12_RS14655	COG2211	Major facilitator Superfamily
DSAG12_RS14695	COG1850	ribulose-bisphosphate carboxylase activity
DSAG12_RS14715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSAG12_RS14755	COG0109	protoheme IX farnesyltransferase activity
DSAG12_RS14765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DSAG12_RS14815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSAG12_RS14830	COG4191	Histidine kinase
DSAG12_RS14830	COG0784	Response regulator, receiver
DSAG12_RS14920	COG1194	a g-specific adenine glycosylase
DSAG12_RS14945	COG5002	protein histidine kinase activity
DSAG12_RS15050	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DSAG12_RS15075	COG1194	a g-specific adenine glycosylase
DSAG12_RS15095	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSAG12_RS15110	COG4152	abc transporter atp-binding protein
DSAG12_RS15140	COG2814	Major facilitator Superfamily
DSAG12_RS15200	COG3033	Beta-eliminating lyase
DSAG12_RS15215	COG1260	myo-inositol-1-phosphate synthase
DSAG12_RS15235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSAG12_RS15250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSAG12_RS15255	COG0601	transmembrane transport
DSAG12_RS15290	COG0444	Belongs to the ABC transporter superfamily
DSAG12_RS15295	COG4608	Belongs to the ABC transporter superfamily
DSAG12_RS15315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DSAG12_RS15320	COG0492	ferredoxin-NADP+ reductase activity
DSAG12_RS15355	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DSAG12_RS15370	COG4152	abc transporter atp-binding protein
DSAG12_RS15390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DSAG12_RS15425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DSAG12_RS15455	COG2814	Major facilitator Superfamily
DSAG12_RS15490	COG1063	alcohol dehydrogenase
DSAG12_RS15520	COG0596	Alpha beta hydrolase
DSAG12_RS15525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DSAG12_RS15530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSAG12_RS15545	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
DSAG12_RS15595	COG0204	Acyl-transferase
DSAG12_RS15690	COG0519	Catalyzes the synthesis of GMP from XMP
DSAG12_RS15695	COG1968	undecaprenyl-diphosphatase activity
DSAG12_RS15710	COG1278	Cold shock
DSAG12_RS15735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSAG12_RS15760	COG0420	3'-5' exonuclease activity
DSAG12_RS15765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DSAG12_RS15830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSAG12_RS15860	COG0842	Transport permease protein
DSAG12_RS15890	COG2211	Major facilitator Superfamily
DSAG12_RS15895	COG0427	acetyl-CoA hydrolase
DSAG12_RS15960	COG1960	acyl-CoA dehydrogenase activity
DSAG12_RS15985	COG0330	HflC and HflK could
DSAG12_RS16030	COG0737	Belongs to the 5'-nucleotidase family
DSAG12_RS16040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DSAG12_RS16045	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSAG12_RS16125	COG0456	acetyltransferase
DSAG12_RS16130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DSAG12_RS16145	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS16155	COG4667	esterase of the alpha-beta hydrolase superfamily
DSAG12_RS16165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSAG12_RS16175	COG0215	cysteine-tRNA ligase activity
DSAG12_RS16230	COG0542	response to heat
DSAG12_RS16245	COG0358	DNA primase activity
DSAG12_RS16295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSAG12_RS16295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSAG12_RS16320	COG1136	(ABC) transporter
DSAG12_RS16385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSAG12_RS16405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSAG12_RS16410	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS16415	COG1902	pentaerythritol trinitrate reductase activity
DSAG12_RS16415	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSAG12_RS16430	COG0800	Aldolase
DSAG12_RS16440	COG0673	inositol 2-dehydrogenase activity
DSAG12_RS16455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DSAG12_RS16475	COG1122	ATPase activity
DSAG12_RS16495	COG1234	tRNA 3'-trailer cleavage
DSAG12_RS16505	COG0515	serine threonine protein kinase
DSAG12_RS16505	COG2815	serine threonine protein kinase
DSAG12_RS16560	COG0785	Cytochrome C biogenesis protein
DSAG12_RS16610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSAG12_RS16635	COG1971	Probably functions as a manganese efflux pump
DSAG12_RS16685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DSAG12_RS16780	COG0124	histidyl-tRNA synthetase
DSAG12_RS16795	COG1278	Cold shock
DSAG12_RS16800	COG0647	UMP catabolic process
DSAG12_RS16810	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSAG12_RS16845	COG2382	esterase
DSAG12_RS16855	COG1185	polyribonucleotide nucleotidyltransferase activity
DSAG12_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS16925	COG0584	glycerophosphoryl diester phosphodiesterase
DSAG12_RS16930	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
DSAG12_RS16945	COG0300	oxidoreductase activity
DSAG12_RS16970	COG0436	Aminotransferase
DSAG12_RS16975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DSAG12_RS16980	COG2086	electron transfer activity
DSAG12_RS16990	COG1960	acyl-CoA dehydrogenase activity
DSAG12_RS17030	COG1522	sequence-specific DNA binding
DSAG12_RS17160	COG4608	Belongs to the ABC transporter superfamily
DSAG12_RS17165	COG0444	Belongs to the ABC transporter superfamily
DSAG12_RS17170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSAG12_RS17175	COG0601	transmembrane transport
DSAG12_RS17260	COG1234	tRNA 3'-trailer cleavage
DSAG12_RS17290	COG0174	glutamine synthetase
DSAG12_RS17300	COG0504	CTP synthase activity
DSAG12_RS17305	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DSAG12_RS17350	COG0671	phosphoesterase, PA-phosphatase related
DSAG12_RS17355	COG1196	nuclear chromosome segregation
DSAG12_RS17375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DSAG12_RS17380	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DSAG12_RS17420	COG0484	heat shock protein binding
DSAG12_RS17440	COG0584	glycerophosphoryl diester phosphodiesterase
DSAG12_RS17475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSAG12_RS17480	COG0688	phosphatidylethanolamine metabolic process
DSAG12_RS17520	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DSAG12_RS17535	COG1763	Mo-molybdopterin cofactor biosynthetic process
DSAG12_RS17705	COG1100	Small GTP-binding protein
DSAG12_RS17940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSAG12_RS17990	COG0546	phosphoglycolate phosphatase activity
DSAG12_RS17995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DSAG12_RS18045	COG1136	(ABC) transporter
DSAG12_RS18115	COG1418	mRNA catabolic process
DSAG12_RS18125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSAG12_RS18135	COG0066	3-isopropylmalate dehydratase activity
DSAG12_RS18140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DSAG12_RS18155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSAG12_RS18160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSAG12_RS18185	COG2197	response regulator
DSAG12_RS18205	COG1254	Belongs to the acylphosphatase family
DSAG12_RS18225	COG0072	phenylalanine-tRNA ligase activity
DSAG12_RS18235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSAG12_RS18250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DSAG12_RS18265	COG0571	ribonuclease III activity
DSAG12_RS18295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSAG12_RS18410	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DSAG12_RS18415	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DSAG12_RS18420	COG2048	Heterodisulfide reductase, subunit B
DSAG12_RS18430	COG0251	oxidation-reduction process
DSAG12_RS18450	COG1522	sequence-specific DNA binding
DSAG12_RS18450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSAG12_RS18460	COG0488	(ABC) transporter
DSAG12_RS18465	COG1160	GTP binding
DSAG12_RS18500	COG0174	glutamine synthetase
DSAG12_RS18505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSAG12_RS18605	COG2814	Major facilitator Superfamily
DSAG12_RS18655	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSAG12_RS18665	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS18690	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS18730	COG3875	lactate racemase activity
DSAG12_RS18810	COG0574	Belongs to the PEP-utilizing enzyme family
DSAG12_RS18810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSAG12_RS18830	COG0540	Belongs to the ATCase OTCase family
DSAG12_RS18865	COG0574	Belongs to the PEP-utilizing enzyme family
DSAG12_RS18865	COG3848	Pyruvate phosphate dikinase
DSAG12_RS18885	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSAG12_RS18890	COG2267	carboxylic ester hydrolase activity
DSAG12_RS18915	COG1185	polyribonucleotide nucleotidyltransferase activity
DSAG12_RS18935	COG1522	sequence-specific DNA binding
DSAG12_RS18955	COG2226	methyltransferase
DSAG12_RS18960	COG0798	PFAM Bile acid sodium symporter
DSAG12_RS18975	COG0826	peptidase U32
DSAG12_RS19015	COG0071	Belongs to the small heat shock protein (HSP20) family
DSAG12_RS19030	COG0644	oxidoreductase
DSAG12_RS19090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSAG12_RS19140	COG2814	Major facilitator Superfamily
DSAG12_RS19145	COG1564	THIamine pyrophosphokinase
DSAG12_RS19160	COG1178	ABC-type Fe3 transport system permease component
DSAG12_RS19165	COG3842	ATPase activity
DSAG12_RS19235	COG0318	PFAM AMP-dependent synthetase and ligase
DSAG12_RS19245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DSAG12_RS19270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSAG12_RS19300	COG1546	Belongs to the CinA family
DSAG12_RS19300	COG1058	Belongs to the CinA family
DSAG12_RS19320	COG0183	Belongs to the thiolase family
DSAG12_RS19360	COG1131	(ABC) transporter
DSAG12_RS19450	COG0735	belongs to the Fur family
DSAG12_RS19455	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DSAG12_RS19470	COG2226	methyltransferase
DSAG12_RS19495	COG0309	Hydrogenase expression formation protein (HypE)
DSAG12_RS19500	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DSAG12_RS19505	COG2267	carboxylic ester hydrolase activity
DSAG12_RS19530	COG2217	Heavy metal translocating P-type atpase
DSAG12_RS19575	COG2391	methyltransferase activity
DSAG12_RS19580	COG0425	Belongs to the sulfur carrier protein TusA family
DSAG12_RS19590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSAG12_RS19600	COG1032	radical SAM domain protein
DSAG12_RS19615	COG2746	aminoglycoside 3-N-acetyltransferase activity