locus-tag	class	description
AArcSl_RS00020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AArcSl_RS00025	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArcSl_RS00045	COG2894	cell division
AArcSl_RS00070	COG1836	PFAM Integral membrane protein DUF92
AArcSl_RS00085	COG2986	histidine ammonia-lyase
AArcSl_RS00150	COG1269	ATP hydrolysis coupled proton transport
AArcSl_RS00175	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AArcSl_RS00195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArcSl_RS00200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_RS00205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AArcSl_RS00210	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AArcSl_RS00215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AArcSl_RS00220	COG0189	ligase activity
AArcSl_RS00230	COG0165	Argininosuccinate lyase
AArcSl_RS00235	COG0137	argininosuccinate synthase activity
AArcSl_RS00245	COG0504	CTP synthase activity
AArcSl_RS00250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArcSl_RS00250	COG0519	Catalyzes the synthesis of GMP from XMP
AArcSl_RS00280	COG2226	methyltransferase
AArcSl_RS00295	COG0181	hydroxymethylbilane synthase activity
AArcSl_RS00305	COG0560	Phosphoserine phosphatase
AArcSl_RS00310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AArcSl_RS00310	COG1796	DNA polymerase
AArcSl_RS00365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AArcSl_RS00375	COG1515	deoxyribonuclease V activity
AArcSl_RS00380	COG0009	L-threonylcarbamoyladenylate synthase
AArcSl_RS00385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AArcSl_RS00390	COG0512	Glutamine amidotransferase of anthranilate synthase
AArcSl_RS00395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArcSl_RS00410	COG0488	(ABC) transporter
AArcSl_RS00430	COG2255	four-way junction helicase activity
AArcSl_RS00435	COG1797	cobyrinic acid a,c-diamide synthase activity
AArcSl_RS00465	COG3425	synthase
AArcSl_RS00520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_RS00525	COG0037	tRNA processing
AArcSl_RS00530	COG0459	protein refolding
AArcSl_RS00540	COG0640	Transcriptional regulator
AArcSl_RS00565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS00580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_RS00590	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS00595	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS00605	COG4166	transmembrane transport
AArcSl_RS00630	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS00645	COG1201	RNA secondary structure unwinding
AArcSl_RS00675	COG0589	response to stress
AArcSl_RS00685	COG0531	amino acid
AArcSl_RS00705	COG0463	Glycosyl transferase, family 2
AArcSl_RS00715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AArcSl_RS00730	COG1253	flavin adenine dinucleotide binding
AArcSl_RS00735	COG0306	phosphate transporter
AArcSl_RS00830	COG1104	cysteine desulfurase activity
AArcSl_RS00840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArcSl_RS00840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_RS00880	COG2271	Major facilitator Superfamily
AArcSl_RS00915	COG2202	Pas domain
AArcSl_RS00915	COG1366	Belongs to the anti-sigma-factor antagonist family
AArcSl_RS00930	COG2217	Heavy metal translocating P-type atpase
AArcSl_RS00935	COG0492	ferredoxin-NADP+ reductase activity
AArcSl_RS01025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AArcSl_RS01030	COG0633	Ferredoxin
AArcSl_RS01085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AArcSl_RS01125	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_RS01140	COG0430	RNA-3'-phosphate cyclase activity
AArcSl_RS01150	COG0517	IMP dehydrogenase activity
AArcSl_RS01150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AArcSl_RS01160	COG0556	nucleotide-excision repair
AArcSl_RS01165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AArcSl_RS01185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AArcSl_RS01195	COG0560	Phosphoserine phosphatase
AArcSl_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS01245	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AArcSl_RS01250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AArcSl_RS01265	COG0822	iron-sulfur transferase activity
AArcSl_RS01285	COG0572	uridine kinase
AArcSl_RS01295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_RS01295	COG4651	solute:proton antiporter activity
AArcSl_RS01305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AArcSl_RS01310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AArcSl_RS01315	COG0343	queuine tRNA-ribosyltransferase activity
AArcSl_RS01340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AArcSl_RS01345	COG0501	Belongs to the peptidase M48B family
AArcSl_RS01405	COG1169	isochorismate synthase
AArcSl_RS01430	COG1404	Belongs to the peptidase S8 family
AArcSl_RS01445	COG0644	oxidoreductase
AArcSl_RS01450	COG0733	neurotransmitter:sodium symporter activity
AArcSl_RS01465	COG0081	regulation of translation
AArcSl_RS01485	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AArcSl_RS01545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AArcSl_RS01565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AArcSl_RS01570	COG2234	aminopeptidase activity
AArcSl_RS01600	COG0534	Mate efflux family protein
AArcSl_RS01605	COG0626	cystathionine gamma-synthase activity
AArcSl_RS01640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AArcSl_RS01650	COG0183	Belongs to the thiolase family
AArcSl_RS01660	COG2267	carboxylic ester hydrolase activity
AArcSl_RS01665	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArcSl_RS01675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_RS01700	COG0215	cysteine-tRNA ligase activity
AArcSl_RS01725	COG0539	negative regulation of cytoplasmic translation
AArcSl_RS01800	COG1268	BioY protein
AArcSl_RS01805	COG1122	ATPase activity
AArcSl_RS01815	COG0247	lactate metabolic process
AArcSl_RS01815	COG2181	nitrate reductase activity
AArcSl_RS01820	COG0187	DNA topoisomerase II activity
AArcSl_RS01820	COG1372	Participates in initiation and elongation during chromosome replication
AArcSl_RS01825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AArcSl_RS01845	COG0484	heat shock protein binding
AArcSl_RS01860	COG0587	DNA-directed DNA polymerase activity
AArcSl_RS01865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AArcSl_RS01870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArcSl_RS01880	COG3842	ATPase activity
AArcSl_RS01890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AArcSl_RS01895	COG0415	Belongs to the DNA photolyase family
AArcSl_RS01965	COG0765	amino acid transport
AArcSl_RS01975	COG0765	amino acid transport
AArcSl_RS02010	COG1695	Transcriptional regulator
AArcSl_RS02015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AArcSl_RS02025	COG0022	dehydrogenase e1 component
AArcSl_RS02040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AArcSl_RS02045	COG0640	Transcriptional regulator
AArcSl_RS02050	COG0798	PFAM Bile acid sodium symporter
AArcSl_RS02060	COG2339	peptidase activity
AArcSl_RS02070	COG1404	Belongs to the peptidase S8 family
AArcSl_RS02095	COG0640	Transcriptional regulator
AArcSl_RS02115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_RS02165	COG0372	Belongs to the citrate synthase family
AArcSl_RS02170	COG0183	Belongs to the thiolase family
AArcSl_RS02190	COG0464	growth
AArcSl_RS02215	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AArcSl_RS02230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AArcSl_RS02240	COG0517	IMP dehydrogenase activity
AArcSl_RS02240	COG0617	tRNA 3'-terminal CCA addition
AArcSl_RS02240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AArcSl_RS02255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_RS02290	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArcSl_RS02295	COG2086	electron transfer activity
AArcSl_RS02325	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
AArcSl_RS02330	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_RS02340	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AArcSl_RS02345	COG5598	trimethylamine methyltransferase
AArcSl_RS02355	COG5012	cobalamin binding
AArcSl_RS02360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArcSl_RS02365	COG0589	response to stress
AArcSl_RS02370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArcSl_RS02380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AArcSl_RS02385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AArcSl_RS02390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArcSl_RS02400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AArcSl_RS02405	COG0436	Aminotransferase
AArcSl_RS02410	COG1960	acyl-CoA dehydrogenase activity
AArcSl_RS02420	COG0667	Aldo Keto reductase
AArcSl_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
AArcSl_RS02440	COG1830	Aldolase
AArcSl_RS02445	COG0159	tryptophan synthase activity
AArcSl_RS02450	COG0133	tryptophan synthase activity
AArcSl_RS02455	COG0134	indole-3-glycerol-phosphate synthase activity
AArcSl_RS02555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AArcSl_RS02560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AArcSl_RS02570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AArcSl_RS02600	COG0673	inositol 2-dehydrogenase activity
AArcSl_RS02605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AArcSl_RS02610	COG0010	Belongs to the arginase family
AArcSl_RS02615	COG1228	amidohydrolase
AArcSl_RS02620	COG1465	3-dehydroquinate synthase
AArcSl_RS02635	COG3573	Dehydrogenase
AArcSl_RS02660	COG1363	Peptidase, m42
AArcSl_RS02675	COG3273	potassium ion transport
AArcSl_RS02675	COG0471	metal ion transport
AArcSl_RS02680	COG1506	peptidase
AArcSl_RS02690	COG2894	cell division
AArcSl_RS02700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArcSl_RS02705	COG0297	glycogen (starch) synthase activity
AArcSl_RS02710	COG0438	transferase activity, transferring glycosyl groups
AArcSl_RS02785	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AArcSl_RS02800	COG0616	signal peptide processing
AArcSl_RS02810	COG1803	Methylglyoxal synthase
AArcSl_RS02840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArcSl_RS02840	COG0519	Catalyzes the synthesis of GMP from XMP
AArcSl_RS02855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AArcSl_RS02865	COG2133	pyrroloquinoline quinone binding
AArcSl_RS02870	COG0049	tRNA binding
AArcSl_RS02895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AArcSl_RS02905	COG0085	RNA polymerase activity
AArcSl_RS02925	COG1022	Amp-dependent synthetase and ligase
AArcSl_RS02950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AArcSl_RS02960	COG0003	Pfam Anion-transporting ATPase
AArcSl_RS03005	COG0309	Hydrogenase expression formation protein (HypE)
AArcSl_RS03010	COG0375	protein maturation
AArcSl_RS03015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AArcSl_RS03020	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AArcSl_RS03055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_RS03060	COG3842	ATPase activity
AArcSl_RS03065	COG1177	transmembrane transport
AArcSl_RS03075	COG1840	ABC-type Fe3 transport system, periplasmic component
AArcSl_RS03085	COG0647	UMP catabolic process
AArcSl_RS03095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AArcSl_RS03110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AArcSl_RS03115	COG1454	alcohol dehydrogenase
AArcSl_RS03125	COG1414	Transcriptional regulator
AArcSl_RS03145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AArcSl_RS03165	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AArcSl_RS03170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AArcSl_RS03175	COG1121	(ABC) transporter
AArcSl_RS03210	COG4974	Belongs to the 'phage' integrase family
AArcSl_RS03235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AArcSl_RS03275	COG1074	ATP-dependent DNA helicase activity
AArcSl_RS03310	COG1401	restriction endodeoxyribonuclease activity
AArcSl_RS03405	COG0200	Binds to the 23S rRNA
AArcSl_RS03430	COG0322	excinuclease ABC activity
AArcSl_RS03435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AArcSl_RS03440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AArcSl_RS03450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AArcSl_RS03465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AArcSl_RS03480	COG0255	Belongs to the universal ribosomal protein uL29 family
AArcSl_RS03485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AArcSl_RS03495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AArcSl_RS03500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AArcSl_RS03505	COG0089	rRNA binding
AArcSl_RS03510	COG0088	Forms part of the polypeptide exit tunnel
AArcSl_RS03515	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AArcSl_RS03550	COG0517	IMP dehydrogenase activity
AArcSl_RS03555	COG0372	Belongs to the citrate synthase family
AArcSl_RS03570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AArcSl_RS03585	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AArcSl_RS03595	COG0459	protein refolding
AArcSl_RS03600	COG2267	carboxylic ester hydrolase activity
AArcSl_RS03635	COG0247	lactate metabolic process
AArcSl_RS03635	COG0277	FAD linked oxidase domain protein
AArcSl_RS03640	COG1620	l-lactate permease
AArcSl_RS03650	COG1139	Iron-sulfur cluster binding protein
AArcSl_RS03740	COG1881	PFAM PEBP family protein
AArcSl_RS03865	COG1194	a g-specific adenine glycosylase
AArcSl_RS03875	COG0271	Belongs to the BolA IbaG family
AArcSl_RS03880	COG0114	fumarate hydratase activity
AArcSl_RS03890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AArcSl_RS03895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AArcSl_RS03905	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AArcSl_RS03910	COG0540	Belongs to the ATCase OTCase family
AArcSl_RS03925	COG1252	NADH dehydrogenase
AArcSl_RS03930	COG0189	ligase activity
AArcSl_RS03945	COG0051	transcription antitermination factor activity, RNA binding
AArcSl_RS03950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AArcSl_RS03955	COG0460	homoserine dehydrogenase
AArcSl_RS03975	COG5002	protein histidine kinase activity
AArcSl_RS03980	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_RS03985	COG0384	phenazine biosynthesis protein PhzF
AArcSl_RS03995	COG0519	Catalyzes the synthesis of GMP from XMP
AArcSl_RS03995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AArcSl_RS04030	COG0309	Hydrogenase expression formation protein (HypE)
AArcSl_RS04035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AArcSl_RS04040	COG1285	pathogenesis
AArcSl_RS04070	COG1278	Cold shock
AArcSl_RS04075	COG1960	acyl-CoA dehydrogenase activity
AArcSl_RS04110	COG1960	acyl-CoA dehydrogenase activity
AArcSl_RS04115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AArcSl_RS04125	COG0517	IMP dehydrogenase activity
AArcSl_RS04150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AArcSl_RS04195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AArcSl_RS04195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AArcSl_RS04205	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AArcSl_RS04220	COG4191	Histidine kinase
AArcSl_RS04235	COG2205	protein histidine kinase activity
AArcSl_RS04240	COG0714	Associated with various cellular activities
AArcSl_RS04260	COG0003	Pfam Anion-transporting ATPase
AArcSl_RS04265	COG0300	oxidoreductase activity
AArcSl_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AArcSl_RS04325	COG2205	protein histidine kinase activity
AArcSl_RS04345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArcSl_RS04390	COG0142	geranyltranstransferase activity
AArcSl_RS04430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AArcSl_RS04435	COG1151	hydroxylamine reductase activity
AArcSl_RS04445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AArcSl_RS04465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AArcSl_RS04470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AArcSl_RS04500	COG0316	Belongs to the HesB IscA family
AArcSl_RS04530	COG0668	transmembrane transport
AArcSl_RS04560	COG1960	acyl-CoA dehydrogenase activity
AArcSl_RS04625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_RS04625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_RS04630	COG1201	RNA secondary structure unwinding
AArcSl_RS04635	COG0656	L-ascorbic acid biosynthetic process
AArcSl_RS04670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AArcSl_RS04680	COG0647	UMP catabolic process
AArcSl_RS04690	COG1063	alcohol dehydrogenase
AArcSl_RS04710	COG4122	O-methyltransferase activity
AArcSl_RS04730	COG1621	beta-fructofuranosidase activity
AArcSl_RS04740	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_RS04745	COG1078	dGTPase activity
AArcSl_RS04780	COG1278	Cold shock
AArcSl_RS04790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AArcSl_RS04820	COG0287	Prephenate dehydrogenase
AArcSl_RS04820	COG1605	Chorismate mutase
AArcSl_RS04840	COG0531	amino acid
AArcSl_RS04845	COG0531	amino acid
AArcSl_RS04850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AArcSl_RS04865	COG0346	lactoylglutathione lyase activity
AArcSl_RS04890	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_RS04900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AArcSl_RS04900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AArcSl_RS04905	COG0673	inositol 2-dehydrogenase activity
AArcSl_RS04910	COG1082	Xylose isomerase domain protein TIM barrel
AArcSl_RS04915	COG0673	inositol 2-dehydrogenase activity
AArcSl_RS04930	COG3842	ATPase activity
AArcSl_RS04935	COG0395	ABC-type sugar transport system, permease component
AArcSl_RS04980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AArcSl_RS04985	COG2890	protein-(glutamine-N5) methyltransferase activity
AArcSl_RS04990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_RS05000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArcSl_RS05005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AArcSl_RS05015	COG1164	Oligoendopeptidase f
AArcSl_RS05020	COG0456	acetyltransferase
AArcSl_RS05030	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AArcSl_RS05035	COG0105	UTP biosynthetic process
AArcSl_RS05060	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AArcSl_RS05090	COG1355	regulation of microtubule-based process
AArcSl_RS05100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArcSl_RS05115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AArcSl_RS05120	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AArcSl_RS05135	COG0535	radical SAM domain protein
AArcSl_RS05140	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AArcSl_RS05155	COG0492	ferredoxin-NADP+ reductase activity
AArcSl_RS05185	COG0667	Aldo Keto reductase
AArcSl_RS05195	COG0459	protein refolding
AArcSl_RS05205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArcSl_RS05225	COG4555	ABC transporter
AArcSl_RS05230	COG0166	Belongs to the GPI family
AArcSl_RS05240	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_RS05245	COG4608	Belongs to the ABC transporter superfamily
AArcSl_RS05250	COG0444	Belongs to the ABC transporter superfamily
AArcSl_RS05255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_RS05260	COG0601	transmembrane transport
AArcSl_RS05280	COG0284	orotidine-5'-phosphate decarboxylase activity
AArcSl_RS05290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AArcSl_RS05295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AArcSl_RS05310	COG1335	isochorismatase
AArcSl_RS05335	COG1024	Enoyl-CoA hydratase
AArcSl_RS05350	COG1733	regulation of RNA biosynthetic process
AArcSl_RS05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AArcSl_RS05360	COG0475	glutathione-regulated potassium exporter activity
AArcSl_RS05360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_RS05365	COG4651	solute:proton antiporter activity
AArcSl_RS05365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_RS05420	COG0235	Class ii aldolase
AArcSl_RS05420	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArcSl_RS05440	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_RS05455	COG0151	Belongs to the GarS family
AArcSl_RS05460	COG0110	maltose O-acetyltransferase activity
AArcSl_RS05490	COG0530	calcium, potassium:sodium antiporter activity
AArcSl_RS05495	COG1234	tRNA 3'-trailer cleavage
AArcSl_RS05500	COG0435	Glutathione S-transferase
AArcSl_RS05510	COG0396	ATPase activity
AArcSl_RS05515	COG0719	Fe-S assembly protein
AArcSl_RS05520	COG0719	Fe-S assembly protein
AArcSl_RS05540	COG0431	NADPH-dependent FMN reductase
AArcSl_RS05545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_RS05560	COG1064	alcohol dehydrogenase
AArcSl_RS05575	COG1111	helicase
AArcSl_RS05575	COG1205	dead DEAH box helicase
AArcSl_RS05580	COG0800	Aldolase
AArcSl_RS05590	COG1131	(ABC) transporter
AArcSl_RS05595	COG0109	protoheme IX farnesyltransferase activity
AArcSl_RS05600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AArcSl_RS05610	COG0596	Alpha beta hydrolase
AArcSl_RS05635	COG1331	Highly conserved protein containing a thioredoxin domain
AArcSl_RS05690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AArcSl_RS05700	COG1522	sequence-specific DNA binding
AArcSl_RS05705	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS05710	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS05710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_RS05715	COG1053	succinate dehydrogenase
AArcSl_RS05725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AArcSl_RS05745	COG0189	ligase activity
AArcSl_RS05755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AArcSl_RS05775	COG0432	Pfam Uncharacterised protein family UPF0047
AArcSl_RS05805	COG2766	serine protein kinase
AArcSl_RS05830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_RS05835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_RS05840	COG0489	protein tyrosine kinase activity
AArcSl_RS05855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AArcSl_RS05890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AArcSl_RS05905	COG0133	tryptophan synthase activity
AArcSl_RS05910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AArcSl_RS05920	COG5598	trimethylamine methyltransferase
AArcSl_RS05935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_RS05935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_RS05950	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AArcSl_RS06005	COG0470	DNA polymerase III
AArcSl_RS06005	COG1067	ATP-dependent peptidase activity
AArcSl_RS06025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AArcSl_RS06035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_RS06040	COG0668	transmembrane transport
AArcSl_RS06085	COG1233	COG1233 Phytoene dehydrogenase and related
AArcSl_RS06095	COG0512	Glutamine amidotransferase of anthranilate synthase
AArcSl_RS06095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArcSl_RS06100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AArcSl_RS06105	COG0135	phosphoribosylanthranilate isomerase activity
AArcSl_RS06110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AArcSl_RS06125	COG0442	prolyl-tRNA aminoacylation
AArcSl_RS06140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_RS06170	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArcSl_RS06175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AArcSl_RS06245	COG3422	double-strand break repair
AArcSl_RS06255	COG0589	response to stress
AArcSl_RS06270	COG1321	iron dependent repressor
AArcSl_RS06280	COG0210	DNA helicase
AArcSl_RS06305	COG2309	aminopeptidase activity
AArcSl_RS06315	COG0559	Belongs to the binding-protein-dependent transport system permease family
AArcSl_RS06340	COG0733	neurotransmitter:sodium symporter activity
AArcSl_RS06355	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06360	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06365	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06370	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06375	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06395	COG1320	monovalent cation:proton antiporter activity
AArcSl_RS06630	COG0484	heat shock protein binding
AArcSl_RS06685	COG0124	histidyl-tRNA synthetase
AArcSl_RS06690	COG0101	tRNA pseudouridine synthase activity
AArcSl_RS06740	COG0346	lactoylglutathione lyase activity
AArcSl_RS06745	COG0667	Aldo Keto reductase
AArcSl_RS06765	COG0366	Alpha amylase catalytic
AArcSl_RS06770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AArcSl_RS06830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArcSl_RS06840	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AArcSl_RS06855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AArcSl_RS06865	COG0070	glutamate synthase
AArcSl_RS06865	COG0067	glutamate synthase
AArcSl_RS06865	COG0069	glutamate synthase activity
AArcSl_RS06875	COG1960	acyl-CoA dehydrogenase activity
AArcSl_RS06885	COG2212	antiporter activity
AArcSl_RS06890	COG1320	monovalent cation:proton antiporter activity
AArcSl_RS06905	COG1006	Multisubunit Na H antiporter MnhC subunit
AArcSl_RS06910	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06915	COG0651	ATP synthesis coupled electron transport
AArcSl_RS06920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AArcSl_RS06920	COG2111	Na H antiporter
AArcSl_RS06925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_RS06930	COG0071	Belongs to the small heat shock protein (HSP20) family
AArcSl_RS06940	COG4191	Histidine kinase
AArcSl_RS06970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AArcSl_RS06985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AArcSl_RS07015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArcSl_RS07035	COG3833	ABC-type maltose transport systems, permease component
AArcSl_RS07040	COG1175	transmembrane transport
AArcSl_RS07050	COG3842	ATPase activity
AArcSl_RS07085	COG1640	4-alpha-glucanotransferase
AArcSl_RS07100	COG4221	oxidoreductase activity
AArcSl_RS07140	COG0585	pseudouridine synthase activity
AArcSl_RS07155	COG0301	tRNA thio-modification
AArcSl_RS07160	COG0717	Belongs to the dCTP deaminase family
AArcSl_RS07175	COG0443	Heat shock 70 kDa protein
AArcSl_RS07190	COG0784	Response regulator, receiver
AArcSl_RS07190	COG4191	Histidine kinase
AArcSl_RS07200	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArcSl_RS07220	COG0126	phosphoglycerate kinase activity
AArcSl_RS07225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AArcSl_RS07255	COG4770	biotin carboxylase activity
AArcSl_RS07275	COG1473	amidohydrolase
AArcSl_RS07315	COG0017	Asparaginyl-tRNA synthetase
AArcSl_RS07325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AArcSl_RS07330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_RS07340	COG0589	response to stress
AArcSl_RS07435	COG1047	Peptidyl-prolyl cis-trans
AArcSl_RS07475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS07490	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AArcSl_RS07495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AArcSl_RS07505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_RS07520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AArcSl_RS07530	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_RS07545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AArcSl_RS07565	COG1132	(ABC) transporter
AArcSl_RS07575	COG0805	protein transport
AArcSl_RS07580	COG0805	protein transport
AArcSl_RS07590	COG1458	PINc domain ribonuclease
AArcSl_RS07595	COG0235	Class ii aldolase
AArcSl_RS07600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AArcSl_RS07615	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AArcSl_RS07640	COG1196	nuclear chromosome segregation
AArcSl_RS07660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AArcSl_RS07665	COG2154	pterin-4-alpha-carbinolamine dehydratase
AArcSl_RS07680	COG0303	'Molybdopterin
AArcSl_RS07700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AArcSl_RS07705	COG1215	transferase activity, transferring glycosyl groups
AArcSl_RS07725	COG1216	Glycosyl transferase, family 2
AArcSl_RS07735	COG2226	methyltransferase
AArcSl_RS07760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AArcSl_RS07775	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS07780	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS07780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_RS07790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_RS07790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AArcSl_RS07805	COG0534	Mate efflux family protein
AArcSl_RS07815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArcSl_RS07820	COG0436	Aminotransferase
AArcSl_RS07835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AArcSl_RS07850	COG1234	tRNA 3'-trailer cleavage
AArcSl_RS07880	COG4946	Tricorn protease homolog
AArcSl_RS07880	COG1506	peptidase
AArcSl_RS07880	COG0823	Involved in the tonB-independent uptake of proteins
AArcSl_RS07890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AArcSl_RS07900	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AArcSl_RS07915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AArcSl_RS07925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AArcSl_RS07935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArcSl_RS07950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AArcSl_RS07975	COG0501	Belongs to the peptidase M48B family
AArcSl_RS07990	COG2239	Acts as a magnesium transporter
AArcSl_RS07995	COG2239	Acts as a magnesium transporter
AArcSl_RS08020	COG1757	Na H antiporter
AArcSl_RS08025	COG0501	Belongs to the peptidase M48B family
AArcSl_RS08045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArcSl_RS08050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AArcSl_RS08055	COG1845	cytochrome c oxidase, subunit III
AArcSl_RS08150	COG1403	HNH endonuclease
AArcSl_RS08260	COG0210	DNA helicase
AArcSl_RS08310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AArcSl_RS08585	COG0557	exoribonuclease II activity
AArcSl_RS08625	COG0113	porphobilinogen synthase activity
AArcSl_RS08645	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_RS08655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AArcSl_RS08660	COG3639	organic phosphonate transmembrane transporter activity
AArcSl_RS08665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AArcSl_RS08675	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AArcSl_RS08705	COG0667	Aldo Keto reductase
AArcSl_RS08715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AArcSl_RS08720	COG0095	Lipoate-protein ligase
AArcSl_RS08725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_RS08730	COG2827	Endonuclease containing a URI domain
AArcSl_RS08740	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AArcSl_RS08745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AArcSl_RS08765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AArcSl_RS08780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AArcSl_RS08790	COG0018	arginyl-trna synthetase
AArcSl_RS08805	COG0633	Ferredoxin
AArcSl_RS08860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS08885	COG0405	Gamma-glutamyltransferase
AArcSl_RS08895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArcSl_RS08900	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_RS08905	COG1575	Belongs to the MenA family. Type 1 subfamily
AArcSl_RS08925	COG1278	Cold shock
AArcSl_RS08930	COG0864	Transcriptional regulator
AArcSl_RS08935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AArcSl_RS08950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AArcSl_RS09015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_RS09025	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AArcSl_RS09030	COG0140	phosphoribosyl-ATP diphosphatase activity
AArcSl_RS09030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AArcSl_RS09050	COG1136	(ABC) transporter
AArcSl_RS09050	COG0577	efflux transmembrane transporter activity
AArcSl_RS09055	COG1136	(ABC) transporter
AArcSl_RS09055	COG0577	efflux transmembrane transporter activity
AArcSl_RS09075	COG1131	(ABC) transporter
AArcSl_RS09115	COG0123	including yeast histone deacetylase and acetoin utilization protein
AArcSl_RS09130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AArcSl_RS09145	COG3842	ATPase activity
AArcSl_RS09165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AArcSl_RS09180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AArcSl_RS09185	COG1151	hydroxylamine reductase activity
AArcSl_RS09195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AArcSl_RS09200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AArcSl_RS09230	COG0322	excinuclease ABC activity
AArcSl_RS09235	COG0039	L-malate dehydrogenase activity
AArcSl_RS09265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArcSl_RS09270	COG0626	cystathionine gamma-synthase activity
AArcSl_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS09305	COG0175	sulfate reduction
AArcSl_RS09335	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS09340	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS09355	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS09355	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_RS09360	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS09370	COG2878	Part of a membrane complex involved in electron transport
AArcSl_RS09375	COG0247	lactate metabolic process
AArcSl_RS09380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArcSl_RS09385	COG2086	electron transfer activity
AArcSl_RS09415	COG0495	leucyl-tRNA aminoacylation
AArcSl_RS09420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AArcSl_RS09425	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS09435	COG1193	negative regulation of DNA recombination
AArcSl_RS09450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_RS09455	COG2391	methyltransferase activity
AArcSl_RS09460	COG2391	methyltransferase activity
AArcSl_RS09465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_RS09465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArcSl_RS09470	COG0425	Belongs to the sulfur carrier protein TusA family
AArcSl_RS09475	COG2210	Belongs to the sulfur carrier protein TusA family
AArcSl_RS09480	COG3118	belongs to the thioredoxin family
AArcSl_RS09495	COG2873	o-acetylhomoserine
AArcSl_RS09500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AArcSl_RS09550	COG0425	Belongs to the sulfur carrier protein TusA family
AArcSl_RS09605	COG2226	methyltransferase
AArcSl_RS09620	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS09625	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_RS09650	COG0697	spore germination
AArcSl_RS09660	COG0644	oxidoreductase
AArcSl_RS09665	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AArcSl_RS09670	COG2086	electron transfer activity
AArcSl_RS09685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AArcSl_RS09705	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AArcSl_RS09715	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_RS09750	COG0346	lactoylglutathione lyase activity
AArcSl_RS09760	COG0446	pyridine nucleotide-disulphide oxidoreductase
AArcSl_RS09775	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_RS09780	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS09795	COG3381	protein complex oligomerization
AArcSl_RS09800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AArcSl_RS09810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AArcSl_RS09830	COG0710	3-dehydroquinate dehydratase activity
AArcSl_RS09840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AArcSl_RS09845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_RS09850	COG1522	sequence-specific DNA binding
AArcSl_RS09865	COG1024	Enoyl-CoA hydratase
AArcSl_RS09875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AArcSl_RS09885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AArcSl_RS09925	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AArcSl_RS09950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AArcSl_RS09975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArcSl_RS09990	COG3118	belongs to the thioredoxin family
AArcSl_RS09995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AArcSl_RS10005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AArcSl_RS10010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AArcSl_RS10040	COG0330	HflC and HflK could
AArcSl_RS10055	COG0463	Glycosyl transferase, family 2
AArcSl_RS10070	COG1185	polyribonucleotide nucleotidyltransferase activity
AArcSl_RS10085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AArcSl_RS10085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AArcSl_RS10100	COG1063	alcohol dehydrogenase
AArcSl_RS10120	COG0436	Aminotransferase
AArcSl_RS10150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AArcSl_RS10165	COG1271	oxidase subunit
AArcSl_RS10170	COG0459	protein refolding
AArcSl_RS10180	COG1446	asparaginase
AArcSl_RS10185	COG0024	Methionine aminopeptidase
AArcSl_RS10235	COG1691	(AIR) carboxylase
AArcSl_RS10240	COG1606	tRNA processing
AArcSl_RS10255	COG1250	3-hydroxyacyl-CoA dehydrogenase
AArcSl_RS10260	COG1546	Belongs to the CinA family
AArcSl_RS10260	COG1058	Belongs to the CinA family
AArcSl_RS10280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AArcSl_RS10325	COG4608	Belongs to the ABC transporter superfamily
AArcSl_RS10330	COG0444	Belongs to the ABC transporter superfamily
AArcSl_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_RS10340	COG0601	transmembrane transport
AArcSl_RS10350	COG0601	transmembrane transport
AArcSl_RS10355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_RS10360	COG0444	Belongs to the ABC transporter superfamily
AArcSl_RS10365	COG4608	Belongs to the ABC transporter superfamily
AArcSl_RS10390	COG1902	pentaerythritol trinitrate reductase activity
AArcSl_RS10405	COG0516	GMP reductase activity
AArcSl_RS10405	COG0517	IMP dehydrogenase activity
AArcSl_RS10425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AArcSl_RS10430	COG0521	Mo-molybdopterin cofactor biosynthetic process
AArcSl_RS10495	COG1045	serine acetyltransferase
AArcSl_RS10540	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS10545	COG0633	Ferredoxin
AArcSl_RS10575	COG0107	imidazoleglycerol-phosphate synthase activity
AArcSl_RS10580	COG0252	asparaginase activity
AArcSl_RS10585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AArcSl_RS10605	COG0563	adenylate kinase activity
AArcSl_RS10645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AArcSl_RS10675	COG0644	oxidoreductase
AArcSl_RS10685	COG2086	electron transfer activity
AArcSl_RS10690	COG0348	domain, Protein
AArcSl_RS10695	COG2239	Acts as a magnesium transporter
AArcSl_RS10725	COG0733	neurotransmitter:sodium symporter activity
AArcSl_RS10745	COG0281	malic enzyme
AArcSl_RS10745	COG0280	phosphate acetyltransferase
AArcSl_RS10760	COG3360	Dodecin
AArcSl_RS10765	COG1444	tRNA N-acetyltransferase activity
AArcSl_RS10775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AArcSl_RS10780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AArcSl_RS10785	COG1254	Belongs to the acylphosphatase family
AArcSl_RS10795	COG1007	ATP synthesis coupled electron transport
AArcSl_RS10810	COG0713	ATP synthesis coupled electron transport
AArcSl_RS10825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArcSl_RS10830	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AArcSl_RS10835	COG0649	NAD binding
AArcSl_RS10840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArcSl_RS10845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AArcSl_RS10865	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AArcSl_RS10875	COG2171	N-acyltransferase activity
AArcSl_RS10880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AArcSl_RS10885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AArcSl_RS10920	COG1079	Belongs to the binding-protein-dependent transport system permease family
AArcSl_RS10925	COG4603	Belongs to the binding-protein-dependent transport system permease family
AArcSl_RS10930	COG3845	ABC transporter
AArcSl_RS10935	COG1744	ABC transporter substrate-binding protein PnrA-like
AArcSl_RS10945	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AArcSl_RS10955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AArcSl_RS10960	COG0022	dehydrogenase e1 component
AArcSl_RS10970	COG0006	proline dipeptidase activity
AArcSl_RS10975	COG0714	Associated with various cellular activities
AArcSl_RS11010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AArcSl_RS11025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AArcSl_RS11050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AArcSl_RS11060	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AArcSl_RS11065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AArcSl_RS11075	COG1492	cobalamin metabolic process
AArcSl_RS11080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_RS11085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AArcSl_RS11095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AArcSl_RS11130	COG1741	Belongs to the pirin family
AArcSl_RS11155	COG1174	glycine betaine transport
AArcSl_RS11195	COG1414	Transcriptional regulator
AArcSl_RS11205	COG3119	arylsulfatase activity
AArcSl_RS11210	COG1454	alcohol dehydrogenase
AArcSl_RS11225	COG0641	radical SAM
AArcSl_RS11285	COG1074	ATP-dependent DNA helicase activity
AArcSl_RS11295	COG1403	HNH endonuclease
AArcSl_RS11305	COG0210	DNA helicase
AArcSl_RS11405	COG4555	ABC transporter
AArcSl_RS11435	COG0346	lactoylglutathione lyase activity
AArcSl_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS11465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AArcSl_RS11475	COG0436	Aminotransferase
AArcSl_RS11485	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS11505	COG2379	hydroxypyruvate reductase
AArcSl_RS11550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AArcSl_RS11680	COG2814	Major facilitator Superfamily
AArcSl_RS11705	COG4533	DNA binding
AArcSl_RS11710	COG0601	transmembrane transport
AArcSl_RS11715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_RS11720	COG0444	Belongs to the ABC transporter superfamily
AArcSl_RS11725	COG4608	Belongs to the ABC transporter superfamily
AArcSl_RS11730	COG1830	Aldolase
AArcSl_RS11735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AArcSl_RS11760	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AArcSl_RS11765	COG3264	Mechanosensitive ion channel
AArcSl_RS11765	COG1196	nuclear chromosome segregation
AArcSl_RS11775	COG0116	Belongs to the methyltransferase superfamily
AArcSl_RS11775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AArcSl_RS11790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AArcSl_RS11805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AArcSl_RS11825	COG2271	Major facilitator Superfamily
AArcSl_RS11865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AArcSl_RS11865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AArcSl_RS11870	COG0315	cyclic pyranopterin monophosphate synthase activity
AArcSl_RS11875	COG0589	response to stress
AArcSl_RS11880	COG4974	Belongs to the 'phage' integrase family
AArcSl_RS11890	COG0434	BtpA family
AArcSl_RS11895	COG0494	nUDIX hydrolase
AArcSl_RS11910	COG3976	FMN-binding domain protein
AArcSl_RS11910	COG1053	succinate dehydrogenase
AArcSl_RS11915	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_RS11930	COG0534	Mate efflux family protein
AArcSl_RS11950	COG0306	phosphate transporter
AArcSl_RS11965	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS11980	COG0633	Ferredoxin
AArcSl_RS12000	COG0535	radical SAM domain protein
AArcSl_RS12015	COG3404	Formiminotransferase-cyclodeaminase
AArcSl_RS12040	COG1140	nitrate reductase beta subunit
AArcSl_RS12045	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AArcSl_RS12055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AArcSl_RS12060	COG0723	plastoquinol--plastocyanin reductase activity
AArcSl_RS12090	COG0589	response to stress
AArcSl_RS12110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_RS12115	COG0509	glycine decarboxylation via glycine cleavage system
AArcSl_RS12120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AArcSl_RS12125	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AArcSl_RS12130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArcSl_RS12140	COG1522	sequence-specific DNA binding
AArcSl_RS12170	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AArcSl_RS12190	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AArcSl_RS12210	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AArcSl_RS12230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AArcSl_RS12235	COG1013	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS12240	COG0674	pyruvate-flavodoxin oxidoreductase activity
AArcSl_RS12240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AArcSl_RS12260	COG0471	metal ion transport
AArcSl_RS12270	COG1047	Peptidyl-prolyl cis-trans
AArcSl_RS12275	COG0531	amino acid
AArcSl_RS12280	COG1324	tolerance protein
AArcSl_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS12295	COG1304	FMN binding
AArcSl_RS12365	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AArcSl_RS12405	COG1132	(ABC) transporter
AArcSl_RS12410	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AArcSl_RS12410	COG0778	Nitroreductase
AArcSl_RS12430	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_RS12435	COG0346	lactoylglutathione lyase activity
AArcSl_RS12480	COG5002	protein histidine kinase activity
AArcSl_RS12485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArcSl_RS12515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AArcSl_RS12520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AArcSl_RS12525	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
AArcSl_RS12530	COG0247	lactate metabolic process
AArcSl_RS12545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AArcSl_RS12550	COG0303	'Molybdopterin
AArcSl_RS12555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AArcSl_RS12570	COG0709	Synthesizes selenophosphate from selenide and ATP
AArcSl_RS12575	COG3608	succinylglutamate desuccinylase aspartoacylase
AArcSl_RS12575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AArcSl_RS12595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AArcSl_RS12605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AArcSl_RS12610	COG2080	2 iron, 2 sulfur cluster binding
AArcSl_RS12610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AArcSl_RS12635	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_RS12645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AArcSl_RS12650	COG0549	Belongs to the carbamate kinase family
AArcSl_RS12655	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AArcSl_RS12665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AArcSl_RS12675	COG0402	S-adenosylhomocysteine deaminase activity
AArcSl_RS12680	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AArcSl_RS12685	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AArcSl_RS12690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AArcSl_RS12695	COG0840	transmembrane signaling receptor activity
AArcSl_RS12700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AArcSl_RS12710	COG2252	PERMEase
AArcSl_RS12715	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AArcSl_RS12720	COG0778	Nitroreductase
AArcSl_RS12720	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AArcSl_RS12740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AArcSl_RS12755	COG2814	Major facilitator Superfamily
AArcSl_RS12760	COG1414	Transcriptional regulator
AArcSl_RS12785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AArcSl_RS12805	COG1063	alcohol dehydrogenase
AArcSl_RS12810	COG1028	Short-chain dehydrogenase reductase Sdr
AArcSl_RS12820	COG2267	carboxylic ester hydrolase activity
AArcSl_RS12835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AArcSl_RS12840	COG1120	ATPase activity
AArcSl_RS12845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AArcSl_RS12865	COG0252	asparaginase activity
AArcSl_RS12950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AArcSl_RS12965	COG1078	dGTPase activity
AArcSl_RS13020	COG0318	PFAM AMP-dependent synthetase and ligase
AArcSl_RS13070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AArcSl_RS13090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AArcSl_RS13095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AArcSl_RS13115	COG0277	FAD linked oxidase domain protein
AArcSl_RS13145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AArcSl_RS13150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AArcSl_RS13185	COG0463	Glycosyl transferase, family 2
AArcSl_RS13185	COG1216	Glycosyl transferase, family 2
AArcSl_RS13190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AArcSl_RS13200	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AArcSl_RS13205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AArcSl_RS13215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AArcSl_RS13240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AArcSl_RS13245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AArcSl_RS13250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AArcSl_RS13255	COG0420	3'-5' exonuclease activity
AArcSl_RS13265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AArcSl_RS13270	COG0154	amidase activity
AArcSl_RS13275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AArcSl_RS13290	COG0346	lactoylglutathione lyase activity
AArcSl_RS13315	COG0505	Belongs to the CarA family
AArcSl_RS13320	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AArcSl_RS13350	COG1278	Cold shock
AArcSl_RS13360	COG1233	COG1233 Phytoene dehydrogenase and related
AArcSl_RS13380	COG2197	response regulator
AArcSl_RS13410	COG0473	3-isopropylmalate dehydrogenase activity
AArcSl_RS13415	COG0066	3-isopropylmalate dehydratase activity
AArcSl_RS13420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AArcSl_RS13430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AArcSl_RS13440	COG0028	Belongs to the TPP enzyme family
AArcSl_RS13445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AArcSl_RS13460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AArcSl_RS13465	COG0083	homoserine kinase activity
AArcSl_RS13485	COG0535	radical SAM domain protein
AArcSl_RS13495	COG0604	alcohol dehydrogenase
AArcSl_RS13495	COG3321	synthase
AArcSl_RS13515	COG0243	molybdopterin cofactor binding
AArcSl_RS13520	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS13555	COG2135	peptidase activity
AArcSl_RS13575	COG0351	phosphomethylpyrimidine kinase
AArcSl_RS13595	COG0857	belongs to the CobB CobQ family
AArcSl_RS13615	COG0531	amino acid
AArcSl_RS13665	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AArcSl_RS13680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AArcSl_RS13685	COG1234	tRNA 3'-trailer cleavage
AArcSl_RS13690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AArcSl_RS13700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AArcSl_RS13705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AArcSl_RS13710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AArcSl_RS13735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AArcSl_RS13750	COG0148	phosphopyruvate hydratase activity
AArcSl_RS13755	COG0052	Belongs to the universal ribosomal protein uS2 family
AArcSl_RS13760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AArcSl_RS13765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AArcSl_RS13770	COG2146	nitrite reductase [NAD(P)H] activity
AArcSl_RS13775	COG0484	heat shock protein binding
AArcSl_RS13790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AArcSl_RS13795	COG0573	inorganic phosphate transmembrane transporter activity
AArcSl_RS13800	COG0573	inorganic phosphate transmembrane transporter activity
AArcSl_RS13805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArcSl_RS13830	COG0129	dihydroxy-acid dehydratase activity
AArcSl_RS13835	COG0483	inositol monophosphate 1-phosphatase activity
AArcSl_RS13840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AArcSl_RS13870	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS13890	COG3301	Polysulphide reductase, NrfD
AArcSl_RS13900	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AArcSl_RS13905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS13915	COG1607	acyl-coa hydrolase
AArcSl_RS13990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AArcSl_RS14045	COG2202	Pas domain
AArcSl_RS14045	COG1366	Belongs to the anti-sigma-factor antagonist family
AArcSl_RS14060	COG0702	epimerase
AArcSl_RS14070	COG3383	formate dehydrogenase (NAD+) activity
AArcSl_RS14075	COG0437	4 iron, 4 sulfur cluster binding
AArcSl_RS14095	COG0243	molybdopterin cofactor binding
AArcSl_RS14100	COG3381	protein complex oligomerization
AArcSl_RS14105	COG0151	Belongs to the GarS family
AArcSl_RS14135	COG3608	succinylglutamate desuccinylase aspartoacylase
AArcSl_RS14140	COG1840	ABC-type Fe3 transport system, periplasmic component
AArcSl_RS14180	COG1234	tRNA 3'-trailer cleavage
AArcSl_RS14185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AArcSl_RS14200	COG0633	Ferredoxin
AArcSl_RS14210	COG0589	response to stress
AArcSl_RS14235	COG0589	response to stress
AArcSl_RS14255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArcSl_RS14260	COG1960	acyl-CoA dehydrogenase activity
AArcSl_RS14270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AArcSl_RS14275	COG4948	Mandelate Racemase Muconate Lactonizing
AArcSl_RS14300	COG1252	NADH dehydrogenase
AArcSl_RS14305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_RS14320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AArcSl_RS14345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AArcSl_RS14355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AArcSl_RS14365	COG1193	negative regulation of DNA recombination
AArcSl_RS14390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AArcSl_RS14400	COG0142	geranyltranstransferase activity
AArcSl_RS14440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AArcSl_RS14445	COG0012	GTP binding
AArcSl_RS14475	COG1058	Belongs to the CinA family
AArcSl_RS14475	COG1546	Belongs to the CinA family
AArcSl_RS14515	COG0167	dihydroorotate dehydrogenase activity
AArcSl_RS14520	COG0525	valine-tRNA ligase activity
AArcSl_RS14555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AArcSl_RS14565	COG0251	oxidation-reduction process
AArcSl_RS14590	COG1104	cysteine desulfurase activity
AArcSl_RS14600	COG0589	response to stress
AArcSl_RS14605	COG0508	dehydrogenase complex catalyzes the overall conversion of
AArcSl_RS14610	COG3199	ATP-NAD kinase
AArcSl_RS14615	COG0022	dehydrogenase e1 component
AArcSl_RS14620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AArcSl_RS14625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS14735	COG0728	peptidoglycan biosynthetic process
AArcSl_RS14830	COG1132	(ABC) transporter
AArcSl_RS14835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS14840	COG2089	acid synthase
AArcSl_RS14845	COG1083	cytidylyl-transferase
AArcSl_RS14895	COG1216	Glycosyl transferase, family 2
AArcSl_RS14895	COG0463	Glycosyl transferase, family 2
AArcSl_RS14910	COG0438	transferase activity, transferring glycosyl groups
AArcSl_RS14915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AArcSl_RS14925	COG0438	transferase activity, transferring glycosyl groups
AArcSl_RS15015	COG3177	Filamentation induced by cAMP protein fic
AArcSl_RS15035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AArcSl_RS15040	COG0037	tRNA processing
AArcSl_RS15040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AArcSl_RS15055	COG0601	transmembrane transport
AArcSl_RS15060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AArcSl_RS15075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AArcSl_RS15090	COG3422	double-strand break repair
AArcSl_RS15145	COG0589	response to stress
AArcSl_RS15180	COG0047	phosphoribosylformylglycinamidine synthase activity
AArcSl_RS15195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AArcSl_RS15290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AArcSl_RS15300	COG0077	Prephenate dehydratase
AArcSl_RS15300	COG1605	Chorismate mutase
AArcSl_RS15380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AArcSl_RS15380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AArcSl_RS15395	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AArcSl_RS15425	COG0471	metal ion transport
AArcSl_RS15425	COG3273	potassium ion transport
AArcSl_RS15450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AArcSl_RS15460	COG2453	phosphatase
AArcSl_RS15460	COG0671	phosphoesterase, PA-phosphatase related
AArcSl_RS15625	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AArcSl_RS15635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AArcSl_RS15650	COG2409	Drug exporters of the RND superfamily
AArcSl_RS15695	COG2264	protein methyltransferase activity
AArcSl_RS15705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AArcSl_RS15710	COG0581	inorganic phosphate transmembrane transporter activity
AArcSl_RS15715	COG0573	inorganic phosphate transmembrane transporter activity
AArcSl_RS15735	COG2096	Adenosyltransferase
AArcSl_RS15770	COG1522	sequence-specific DNA binding
AArcSl_RS15775	COG0436	Aminotransferase
AArcSl_RS15780	COG0745	RESPONSE REGULATOR receiver
AArcSl_RS15790	COG0517	IMP dehydrogenase activity
AArcSl_RS15790	COG0516	GMP reductase activity
AArcSl_RS15815	COG3402	PFAM membrane-flanked domain
AArcSl_RS15820	COG3842	ATPase activity
AArcSl_RS15895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AArcSl_RS16040	COG1966	Carbon starvation protein
AArcSl_RS16045	COG0003	Pfam Anion-transporting ATPase
AArcSl_RS16060	COG0523	cobalamin synthesis protein
AArcSl_RS16075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AArcSl_RS16080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AArcSl_RS16115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArcSl_RS16120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArcSl_RS16120	COG1648	precorrin-2 dehydrogenase activity
AArcSl_RS16180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AArcSl_RS16180	COG1648	precorrin-2 dehydrogenase activity
AArcSl_RS16190	COG1739	Uncharacterized protein family UPF0029
AArcSl_RS16245	COG0489	protein tyrosine kinase activity
AArcSl_RS16255	COG1063	alcohol dehydrogenase
AArcSl_RS16305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AArcSl_RS16320	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AArcSl_RS16335	COG0656	L-ascorbic acid biosynthetic process
AArcSl_RS16345	COG1940	carbohydrate kinase activity
AArcSl_RS16360	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AArcSl_RS16385	COG0131	Imidazoleglycerol-phosphate dehydratase
AArcSl_RS16475	COG0004	ammonium transporteR
AArcSl_RS16485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AArcSl_RS16495	COG1253	flavin adenine dinucleotide binding
AArcSl_RS16500	COG0423	glycine-tRNA ligase activity
AArcSl_RS16510	COG0556	nucleotide-excision repair
AArcSl_RS16515	COG0330	HflC and HflK could
AArcSl_RS16560	COG0527	aspartate kinase activity
AArcSl_RS16565	COG0546	phosphoglycolate phosphatase activity
AArcSl_RS16580	COG0506	proline dehydrogenase activity