locus-tag	class	description
L21SP5_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L21SP5_RS00010	COG0024	Methionine aminopeptidase
L21SP5_RS00015	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP5_RS00030	COG0501	Belongs to the peptidase M48B family
L21SP5_RS00045	COG3385	transposase activity
L21SP5_RS00070	COG0167	dihydroorotate dehydrogenase activity
L21SP5_RS00075	COG0563	adenylate kinase activity
L21SP5_RS00090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L21SP5_RS00095	COG0542	response to heat
L21SP5_RS00100	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L21SP5_RS00125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L21SP5_RS00130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L21SP5_RS00135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L21SP5_RS00140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L21SP5_RS00155	COG0149	triose-phosphate isomerase activity
L21SP5_RS00160	COG2264	protein methyltransferase activity
L21SP5_RS00180	COG0859	PFAM glycosyl transferase family 9
L21SP5_RS00200	COG0359	binds to the 23S rRNA
L21SP5_RS00205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L21SP5_RS00210	COG0360	Binds together with S18 to 16S ribosomal RNA
L21SP5_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
L21SP5_RS00250	COG1388	LysM domain
L21SP5_RS00250	COG3942	CHAP domain
L21SP5_RS00255	COG3273	potassium ion transport
L21SP5_RS00255	COG0471	metal ion transport
L21SP5_RS00265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L21SP5_RS00280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L21SP5_RS00290	COG0446	pyridine nucleotide-disulphide oxidoreductase
L21SP5_RS00290	COG1902	pentaerythritol trinitrate reductase activity
L21SP5_RS00305	COG4807	Protein conserved in bacteria
L21SP5_RS00310	COG0545	Peptidyl-prolyl cis-trans isomerase
L21SP5_RS00325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L21SP5_RS00330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L21SP5_RS00340	COG0519	Catalyzes the synthesis of GMP from XMP
L21SP5_RS00345	COG4999	Histidine kinase
L21SP5_RS00345	COG2205	protein histidine kinase activity
L21SP5_RS00345	COG3850	Histidine kinase
L21SP5_RS00345	COG3437	response regulator, receiver
L21SP5_RS00365	COG3385	transposase activity
L21SP5_RS00375	COG1484	DNA-dependent DNA replication
L21SP5_RS00380	COG0358	DNA primase activity
L21SP5_RS00465	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS00470	COG0358	DNA primase activity
L21SP5_RS00540	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS00545	COG0358	DNA primase activity
L21SP5_RS00620	COG0358	DNA primase activity
L21SP5_RS00675	COG1476	TRANSCRIPTIONal
L21SP5_RS00725	COG0358	DNA primase activity
L21SP5_RS00730	COG1476	TRANSCRIPTIONal
L21SP5_RS00785	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS00790	COG0358	DNA primase activity
L21SP5_RS00795	COG1396	sequence-specific DNA binding
L21SP5_RS00835	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS00840	COG0358	DNA primase activity
L21SP5_RS00845	COG1396	sequence-specific DNA binding
L21SP5_RS00880	COG3328	transposase activity
L21SP5_RS00895	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS00900	COG0358	DNA primase activity
L21SP5_RS00905	COG1476	TRANSCRIPTIONal
L21SP5_RS00930	COG3385	transposase activity
L21SP5_RS00950	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS00955	COG0358	DNA primase activity
L21SP5_RS00960	COG1476	TRANSCRIPTIONal
L21SP5_RS00990	COG0358	DNA primase activity
L21SP5_RS01010	COG3385	transposase activity
L21SP5_RS01020	COG0358	DNA primase activity
L21SP5_RS01040	COG1484	DNA-dependent DNA replication
L21SP5_RS01075	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
L21SP5_RS01085	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS01090	COG0358	DNA primase activity
L21SP5_RS01115	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
L21SP5_RS01125	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS01130	COG0358	DNA primase activity
L21SP5_RS01140	COG0358	DNA primase activity
L21SP5_RS01245	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS01310	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS01315	COG0358	DNA primase activity
L21SP5_RS01320	COG1396	sequence-specific DNA binding
L21SP5_RS01385	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS01390	COG0358	DNA primase activity
L21SP5_RS01440	COG0534	Mate efflux family protein
L21SP5_RS01445	COG0023	Translation Initiation Factor
L21SP5_RS01455	COG3275	phosphorelay sensor kinase activity
L21SP5_RS01460	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS01490	COG1674	ftsk spoiiie
L21SP5_RS01500	COG2201	protein-glutamate methylesterase activity
L21SP5_RS01530	COG0667	Aldo Keto reductase
L21SP5_RS01535	COG1187	pseudouridine synthase activity
L21SP5_RS01545	COG0492	ferredoxin-NADP+ reductase activity
L21SP5_RS01565	COG2226	methyltransferase
L21SP5_RS01570	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
L21SP5_RS01575	COG2205	protein histidine kinase activity
L21SP5_RS01575	COG2202	Pas domain
L21SP5_RS01590	COG1595	DNA-templated transcription, initiation
L21SP5_RS01630	COG0840	transmembrane signaling receptor activity
L21SP5_RS01635	COG0058	SHG alpha-glucan phosphorylase activity
L21SP5_RS01645	COG0438	transferase activity, transferring glycosyl groups
L21SP5_RS01655	COG2195	Cleaves the N-terminal amino acid of tripeptides
L21SP5_RS01665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L21SP5_RS01680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L21SP5_RS01690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L21SP5_RS01700	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
L21SP5_RS01710	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L21SP5_RS01730	COG1842	Phage shock protein A
L21SP5_RS01755	COG4221	oxidoreductase activity
L21SP5_RS01760	COG2315	Protein conserved in bacteria
L21SP5_RS01775	COG1164	Oligoendopeptidase f
L21SP5_RS01790	COG0811	peptide transport
L21SP5_RS01795	COG0848	biopolymer transport protein
L21SP5_RS01810	COG0427	acetyl-CoA hydrolase
L21SP5_RS01815	COG0285	dihydrofolate synthase activity
L21SP5_RS01820	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L21SP5_RS01880	COG0210	DNA helicase
L21SP5_RS01890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L21SP5_RS01920	COG5002	protein histidine kinase activity
L21SP5_RS01920	COG0784	Response regulator, receiver
L21SP5_RS01950	COG2267	carboxylic ester hydrolase activity
L21SP5_RS01990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L21SP5_RS01990	COG0574	Belongs to the PEP-utilizing enzyme family
L21SP5_RS01995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L21SP5_RS02000	COG0512	Glutamine amidotransferase of anthranilate synthase
L21SP5_RS02005	COG3457	Alanine racemase
L21SP5_RS02015	COG3118	belongs to the thioredoxin family
L21SP5_RS02020	COG3328	transposase activity
L21SP5_RS02035	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS02040	COG3586	endonuclease activity
L21SP5_RS02055	COG0653	protein targeting
L21SP5_RS02090	COG3549	Plasmid maintenance system killer
L21SP5_RS02100	COG1401	restriction endodeoxyribonuclease activity
L21SP5_RS02140	COG3275	phosphorelay sensor kinase activity
L21SP5_RS02145	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS02255	COG3142	Participates in the control of copper homeostasis
L21SP5_RS02260	COG3525	Glycosyl hydrolase, family 20, catalytic domain
L21SP5_RS02265	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
L21SP5_RS02275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L21SP5_RS02280	COG2755	lipolytic protein G-D-S-L family
L21SP5_RS02280	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L21SP5_RS02290	COG1215	transferase activity, transferring glycosyl groups
L21SP5_RS02300	COG0105	UTP biosynthetic process
L21SP5_RS02310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L21SP5_RS02320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L21SP5_RS02370	COG3328	transposase activity
L21SP5_RS02390	COG3385	transposase activity
L21SP5_RS02410	COG3292	Two component regulator propeller
L21SP5_RS02410	COG2205	protein histidine kinase activity
L21SP5_RS02410	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS02415	COG1012	belongs to the aldehyde dehydrogenase family
L21SP5_RS02435	COG0826	peptidase U32
L21SP5_RS02460	COG4176	ABC-type proline glycine betaine transport system permease component
L21SP5_RS02465	COG2113	Glycine betaine
L21SP5_RS02475	COG2885	chlorophyll binding
L21SP5_RS02475	COG3047	cAMP biosynthetic process
L21SP5_RS02485	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
L21SP5_RS02495	COG0436	Aminotransferase
L21SP5_RS02500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L21SP5_RS02505	COG1660	Displays ATPase and GTPase activities
L21SP5_RS02510	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
L21SP5_RS02515	COG0537	adenosine 5'-monophosphoramidase activity
L21SP5_RS02525	COG0784	Response regulator, receiver
L21SP5_RS02525	COG2205	protein histidine kinase activity
L21SP5_RS02530	COG1446	asparaginase
L21SP5_RS02590	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP5_RS02595	COG0022	dehydrogenase e1 component
L21SP5_RS02600	COG0716	FMN binding
L21SP5_RS02610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L21SP5_RS02615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L21SP5_RS02620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L21SP5_RS02630	COG0071	Belongs to the small heat shock protein (HSP20) family
L21SP5_RS02655	COG1595	DNA-templated transcription, initiation
L21SP5_RS02660	COG3958	Transketolase
L21SP5_RS02670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L21SP5_RS02685	COG3385	transposase activity
L21SP5_RS02730	COG0420	3'-5' exonuclease activity
L21SP5_RS02740	COG0500	methyltransferase
L21SP5_RS02770	COG1012	belongs to the aldehyde dehydrogenase family
L21SP5_RS02775	COG1012	belongs to the aldehyde dehydrogenase family
L21SP5_RS02780	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS02785	COG0840	transmembrane signaling receptor activity
L21SP5_RS02790	COG3437	response regulator, receiver
L21SP5_RS02800	COG4585	Histidine kinase
L21SP5_RS02805	COG1074	ATP-dependent DNA helicase activity
L21SP5_RS02815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L21SP5_RS02830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP5_RS02860	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L21SP5_RS02880	COG0545	Peptidyl-prolyl cis-trans isomerase
L21SP5_RS02890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L21SP5_RS02910	COG0702	epimerase
L21SP5_RS02920	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP5_RS02945	COG0492	ferredoxin-NADP+ reductase activity
L21SP5_RS02985	COG1561	YicC-like family, N-terminal region
L21SP5_RS02990	COG0194	GDP metabolic process
L21SP5_RS02995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L21SP5_RS03005	COG0187	DNA topoisomerase II activity
L21SP5_RS03040	COG1132	(ABC) transporter
L21SP5_RS03045	COG1278	Cold shock
L21SP5_RS03110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L21SP5_RS03180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L21SP5_RS03190	COG0424	maF-like protein
L21SP5_RS03195	COG4717	serine-type aminopeptidase activity
L21SP5_RS03215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L21SP5_RS03230	COG2205	protein histidine kinase activity
L21SP5_RS03235	COG1966	Carbon starvation protein
L21SP5_RS03275	COG3328	transposase activity
L21SP5_RS03290	COG5002	protein histidine kinase activity
L21SP5_RS03295	COG3437	response regulator, receiver
L21SP5_RS03300	COG0784	Response regulator, receiver
L21SP5_RS03300	COG2205	protein histidine kinase activity
L21SP5_RS03315	COG3437	response regulator, receiver
L21SP5_RS03320	COG0784	Response regulator, receiver
L21SP5_RS03320	COG2205	protein histidine kinase activity
L21SP5_RS03320	COG5002	protein histidine kinase activity
L21SP5_RS03330	COG4999	Histidine kinase
L21SP5_RS03330	COG3850	Histidine kinase
L21SP5_RS03330	COG3437	response regulator, receiver
L21SP5_RS03330	COG2205	protein histidine kinase activity
L21SP5_RS03335	COG4152	abc transporter atp-binding protein
L21SP5_RS03340	COG1668	transmembrane transport
L21SP5_RS03345	COG0248	Ppx GppA phosphatase
L21SP5_RS03360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L21SP5_RS03370	COG1696	Membrane protein involved in D-alanine export
L21SP5_RS03385	COG0741	lytic transglycosylase activity
L21SP5_RS03395	COG1475	DNA binding
L21SP5_RS03400	COG1192	Involved in chromosome partitioning
L21SP5_RS03405	COG0116	Belongs to the methyltransferase superfamily
L21SP5_RS03410	COG4864	UPF0365 protein
L21SP5_RS03425	COG3385	transposase activity
L21SP5_RS03430	COG2226	methyltransferase
L21SP5_RS03465	COG0564	pseudouridine synthase activity
L21SP5_RS03475	COG2815	serine threonine protein kinase
L21SP5_RS03475	COG0515	serine threonine protein kinase
L21SP5_RS03480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L21SP5_RS03485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L21SP5_RS03500	COG2070	2-Nitropropane dioxygenase
L21SP5_RS03525	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS03535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L21SP5_RS03535	COG1918	ferrous iron import across plasma membrane
L21SP5_RS03560	COG2226	methyltransferase
L21SP5_RS03580	COG0791	NLP P60 protein
L21SP5_RS03580	COG1388	LysM domain
L21SP5_RS03580	COG3103	Sh3 type 3 domain protein
L21SP5_RS03600	COG1705	Flagellar rod assembly protein muramidase FlgJ
L21SP5_RS03605	COG0295	cytidine deaminase activity
L21SP5_RS03610	COG3047	cAMP biosynthetic process
L21SP5_RS03610	COG2885	chlorophyll binding
L21SP5_RS03615	COG0564	pseudouridine synthase activity
L21SP5_RS03620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L21SP5_RS03635	COG0442	prolyl-tRNA aminoacylation
L21SP5_RS03650	COG0318	PFAM AMP-dependent synthetase and ligase
L21SP5_RS03665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L21SP5_RS03680	COG4232	protein-disulfide reductase activity
L21SP5_RS03685	COG0512	Glutamine amidotransferase of anthranilate synthase
L21SP5_RS03685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L21SP5_RS03695	COG1136	(ABC) transporter
L21SP5_RS03700	COG4591	ABC-type transport system involved in lipoprotein release permease component
L21SP5_RS03715	COG1309	transcriptional regulator
L21SP5_RS03725	COG1757	Na H antiporter
L21SP5_RS03770	COG1181	Belongs to the D-alanine--D-alanine ligase family
L21SP5_RS03775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L21SP5_RS03785	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
L21SP5_RS03790	COG3005	denitrification pathway
L21SP5_RS03795	COG1141	Ferredoxin
L21SP5_RS03825	COG1566	PFAM secretion protein HlyD family protein
L21SP5_RS03850	COG2172	sigma factor antagonist activity
L21SP5_RS03900	COG4771	TonB-dependent receptor
L21SP5_RS03905	COG2133	pyrroloquinoline quinone binding
L21SP5_RS03910	COG2204	response regulator
L21SP5_RS03945	COG1484	DNA-dependent DNA replication
L21SP5_RS04005	COG5002	protein histidine kinase activity
L21SP5_RS04010	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS04015	COG0668	transmembrane transport
L21SP5_RS04040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L21SP5_RS04045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L21SP5_RS04060	COG5002	protein histidine kinase activity
L21SP5_RS04090	COG0318	PFAM AMP-dependent synthetase and ligase
L21SP5_RS04135	COG1506	peptidase
L21SP5_RS04135	COG4946	Tricorn protease homolog
L21SP5_RS04135	COG0823	Involved in the tonB-independent uptake of proteins
L21SP5_RS04145	COG2388	GCN5-related N-acetyl-transferase
L21SP5_RS04170	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L21SP5_RS04175	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L21SP5_RS04185	COG0673	inositol 2-dehydrogenase activity
L21SP5_RS04200	COG0366	Alpha amylase catalytic
L21SP5_RS04210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L21SP5_RS04210	COG0473	3-isopropylmalate dehydrogenase activity
L21SP5_RS04265	COG1960	acyl-CoA dehydrogenase activity
L21SP5_RS04270	COG4770	biotin carboxylase activity
L21SP5_RS04280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L21SP5_RS04285	COG4206	TonB-dependent receptor
L21SP5_RS04295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L21SP5_RS04320	COG1295	ribonuclease BN
L21SP5_RS04325	COG5002	protein histidine kinase activity
L21SP5_RS04330	COG1811	Na channel or pump
L21SP5_RS04335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L21SP5_RS04355	COG4242	Belongs to the peptidase S51 family
L21SP5_RS04360	COG4771	TonB-dependent receptor
L21SP5_RS04375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L21SP5_RS04390	COG1187	pseudouridine synthase activity
L21SP5_RS04395	COG2353	YceI-like domain
L21SP5_RS04410	COG0784	Response regulator, receiver
L21SP5_RS04410	COG2205	protein histidine kinase activity
L21SP5_RS04425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L21SP5_RS04440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L21SP5_RS04460	COG3177	Filamentation induced by cAMP protein fic
L21SP5_RS04480	COG2205	protein histidine kinase activity
L21SP5_RS04480	COG0784	Response regulator, receiver
L21SP5_RS04490	COG0343	queuine tRNA-ribosyltransferase activity
L21SP5_RS04495	COG0463	Glycosyl transferase, family 2
L21SP5_RS04505	COG0357	Ribosomal RNA small subunit methyltransferase G
L21SP5_RS04520	COG2067	long-chain fatty acid transport protein
L21SP5_RS04530	COG2885	chlorophyll binding
L21SP5_RS04560	COG0784	Response regulator, receiver
L21SP5_RS04560	COG2205	protein histidine kinase activity
L21SP5_RS04585	COG0612	Peptidase, M16
L21SP5_RS04595	COG0167	dihydroorotate dehydrogenase activity
L21SP5_RS04600	COG0542	response to heat
L21SP5_RS04605	COG2081	HI0933 family
L21SP5_RS04635	COG1032	radical SAM domain protein
L21SP5_RS04645	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L21SP5_RS04690	COG0463	Glycosyl transferase, family 2
L21SP5_RS04730	COG0390	transport system, permease component
L21SP5_RS04735	COG1132	(ABC) transporter
L21SP5_RS04800	COG0006	proline dipeptidase activity
L21SP5_RS04820	COG3328	transposase activity
L21SP5_RS04830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L21SP5_RS04835	COG1702	phosphate starvation-inducible protein PhoH
L21SP5_RS04850	COG3956	TIGRFAM MazG family protein
L21SP5_RS04860	COG3275	phosphorelay sensor kinase activity
L21SP5_RS04875	COG4946	Tricorn protease homolog
L21SP5_RS04875	COG0793	Belongs to the peptidase S41A family
L21SP5_RS04890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L21SP5_RS04900	COG0793	Belongs to the peptidase S41A family
L21SP5_RS04910	COG3172	ATPase kinase involved in NAD metabolism
L21SP5_RS04950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L21SP5_RS04955	COG1082	Xylose isomerase domain protein TIM barrel
L21SP5_RS04960	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L21SP5_RS04965	COG1518	maintenance of DNA repeat elements
L21SP5_RS05005	COG2202	Pas domain
L21SP5_RS05005	COG2205	protein histidine kinase activity
L21SP5_RS05040	COG3328	transposase activity
L21SP5_RS05080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L21SP5_RS05085	COG2205	protein histidine kinase activity
L21SP5_RS05090	COG3033	Beta-eliminating lyase
L21SP5_RS05115	COG1678	Uncharacterized ACR, COG1678
L21SP5_RS05125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L21SP5_RS05135	COG2957	Belongs to the agmatine deiminase family
L21SP5_RS05140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L21SP5_RS05145	COG0484	heat shock protein binding
L21SP5_RS05150	COG1013	pyruvate-flavodoxin oxidoreductase activity
L21SP5_RS05150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L21SP5_RS05150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L21SP5_RS05150	COG0674	pyruvate-flavodoxin oxidoreductase activity
L21SP5_RS05160	COG0791	NLP P60 protein
L21SP5_RS05165	COG0393	Putative heavy-metal-binding
L21SP5_RS05170	COG0494	nUDIX hydrolase
L21SP5_RS05180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L21SP5_RS05185	COG0167	dihydroorotate dehydrogenase activity
L21SP5_RS05210	COG0251	oxidation-reduction process
L21SP5_RS05225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS05235	COG0544	peptidyl-prolyl cis-trans isomerase activity
L21SP5_RS05240	COG0740	serine-type endopeptidase activity
L21SP5_RS05245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L21SP5_RS05255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L21SP5_RS05265	COG1757	Na H antiporter
L21SP5_RS05270	COG2235	arginine
L21SP5_RS05280	COG2239	Acts as a magnesium transporter
L21SP5_RS05285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L21SP5_RS05295	COG2839	Protein conserved in bacteria
L21SP5_RS05300	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L21SP5_RS05305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L21SP5_RS05320	COG3023	N-Acetylmuramoyl-L-alanine amidase
L21SP5_RS05360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L21SP5_RS05395	COG1716	ATPase activity
L21SP5_RS05395	COG1131	(ABC) transporter
L21SP5_RS05395	COG0842	Transport permease protein
L21SP5_RS05410	COG0823	Involved in the tonB-independent uptake of proteins
L21SP5_RS05410	COG1506	peptidase
L21SP5_RS05415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L21SP5_RS05425	COG3590	peptidase
L21SP5_RS05455	COG1233	COG1233 Phytoene dehydrogenase and related
L21SP5_RS05490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L21SP5_RS05495	COG0085	RNA polymerase activity
L21SP5_RS05500	COG0222	ribosome binding
L21SP5_RS05505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L21SP5_RS05510	COG0081	regulation of translation
L21SP5_RS05515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L21SP5_RS05535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L21SP5_RS05565	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS05570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L21SP5_RS05575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP5_RS05585	COG0706	membrane insertase activity
L21SP5_RS05590	COG0504	CTP synthase activity
L21SP5_RS05605	COG0336	Belongs to the RNA methyltransferase TrmD family
L21SP5_RS05615	COG1418	mRNA catabolic process
L21SP5_RS05620	COG2198	Histidine kinase
L21SP5_RS05620	COG0784	Response regulator, receiver
L21SP5_RS05620	COG5002	protein histidine kinase activity
L21SP5_RS05625	COG0784	Response regulator, receiver
L21SP5_RS05625	COG2198	Histidine kinase
L21SP5_RS05625	COG5002	protein histidine kinase activity
L21SP5_RS05635	COG0280	phosphate acetyltransferase
L21SP5_RS05635	COG0281	malic enzyme
L21SP5_RS05645	COG1428	Deoxynucleoside kinase
L21SP5_RS05650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L21SP5_RS05665	COG0488	(ABC) transporter
L21SP5_RS05670	COG2255	four-way junction helicase activity
L21SP5_RS05695	COG0662	Cupin 2, conserved barrel domain protein
L21SP5_RS05700	COG0205	6-phosphofructokinase activity
L21SP5_RS05745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L21SP5_RS05750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L21SP5_RS05755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L21SP5_RS05785	COG0037	tRNA processing
L21SP5_RS05795	COG1473	amidohydrolase
L21SP5_RS05810	COG2205	protein histidine kinase activity
L21SP5_RS05825	COG1570	exodeoxyribonuclease VII activity
L21SP5_RS05840	COG0482	sulfurtransferase activity
L21SP5_RS05900	COG0166	Belongs to the GPI family
L21SP5_RS05905	COG0602	queuosine metabolic process
L21SP5_RS05915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L21SP5_RS05935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS05940	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
L21SP5_RS05955	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP5_RS05970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L21SP5_RS06020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L21SP5_RS06075	COG1373	ATPase (AAA superfamily
L21SP5_RS06080	COG2989	Protein conserved in bacteria
L21SP5_RS06120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L21SP5_RS06130	COG0019	diaminopimelate decarboxylase activity
L21SP5_RS06135	COG0527	aspartate kinase activity
L21SP5_RS06185	COG1342	Belongs to the UPF0251 family
L21SP5_RS06220	COG1863	multisubunit Na H antiporter MnhE subunit
L21SP5_RS06225	COG0651	ATP synthesis coupled electron transport
L21SP5_RS06230	COG1006	Multisubunit Na H antiporter MnhC subunit
L21SP5_RS06240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L21SP5_RS06240	COG2111	Na H antiporter
L21SP5_RS06245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L21SP5_RS06245	COG2111	Na H antiporter
L21SP5_RS06250	COG3261	NADH dehydrogenase
L21SP5_RS06250	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
L21SP5_RS06255	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L21SP5_RS06260	COG3260	NADH ubiquinone oxidoreductase 20
L21SP5_RS06270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L21SP5_RS06300	COG0409	Hydrogenase expression formation protein
L21SP5_RS06325	COG1136	(ABC) transporter
L21SP5_RS06330	COG1136	(ABC) transporter
L21SP5_RS06330	COG0577	efflux transmembrane transporter activity
L21SP5_RS06335	COG0577	efflux transmembrane transporter activity
L21SP5_RS06335	COG1136	(ABC) transporter
L21SP5_RS06350	COG2897	thiosulfate sulfurtransferase activity
L21SP5_RS06360	COG2205	protein histidine kinase activity
L21SP5_RS06360	COG0784	Response regulator, receiver
L21SP5_RS06360	COG5002	protein histidine kinase activity
L21SP5_RS06375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP5_RS06380	COG0217	transcriptional regulatory protein
L21SP5_RS06390	COG0367	asparagine synthase
L21SP5_RS06400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L21SP5_RS06405	COG0688	phosphatidylethanolamine metabolic process
L21SP5_RS06410	COG0575	Belongs to the CDS family
L21SP5_RS06420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L21SP5_RS06425	COG0799	negative regulation of ribosome biogenesis
L21SP5_RS06445	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP5_RS06450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS06455	COG0196	riboflavin kinase activity
L21SP5_RS06460	COG2301	Belongs to the HpcH HpaI aldolase family
L21SP5_RS06470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L21SP5_RS06490	COG0716	FMN binding
L21SP5_RS06495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L21SP5_RS06500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L21SP5_RS06545	COG2234	aminopeptidase activity
L21SP5_RS06600	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L21SP5_RS06620	COG0628	permease
L21SP5_RS06710	COG0604	alcohol dehydrogenase
L21SP5_RS06755	COG1575	Belongs to the MenA family. Type 1 subfamily
L21SP5_RS06780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L21SP5_RS06790	COG0439	Biotin carboxylase
L21SP5_RS06805	COG1484	DNA-dependent DNA replication
L21SP5_RS06840	COG5002	protein histidine kinase activity
L21SP5_RS06855	COG0495	leucyl-tRNA aminoacylation
L21SP5_RS06860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L21SP5_RS06865	COG0739	heme binding
L21SP5_RS06870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L21SP5_RS06895	COG2032	superoxide dismutase activity
L21SP5_RS06950	COG0151	Belongs to the GarS family
L21SP5_RS07015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L21SP5_RS07015	COG1333	cytochrome c biogenesis protein
L21SP5_RS07040	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS07045	COG1404	Belongs to the peptidase S8 family
L21SP5_RS07065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP5_RS07080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L21SP5_RS07090	COG1280	lysine exporter protein (LysE YggA)
L21SP5_RS07095	COG1136	(ABC) transporter
L21SP5_RS07100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L21SP5_RS07110	COG3579	cysteine-type endopeptidase activity
L21SP5_RS07115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L21SP5_RS07120	COG0367	asparagine synthase
L21SP5_RS07125	COG0438	transferase activity, transferring glycosyl groups
L21SP5_RS07140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L21SP5_RS07155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L21SP5_RS07180	COG1496	oxidoreductase activity
L21SP5_RS07185	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L21SP5_RS07185	COG0321	lipoyl(octanoyl) transferase activity
L21SP5_RS07195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L21SP5_RS07200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L21SP5_RS07205	COG2154	pterin-4-alpha-carbinolamine dehydratase
L21SP5_RS07215	COG0463	Glycosyl transferase, family 2
L21SP5_RS07220	COG0488	(ABC) transporter
L21SP5_RS07230	COG0525	valine-tRNA ligase activity
L21SP5_RS07235	COG0436	Aminotransferase
L21SP5_RS07250	COG3876	Protein conserved in bacteria
L21SP5_RS07255	COG4591	ABC-type transport system involved in lipoprotein release permease component
L21SP5_RS07265	COG1137	ATPase activity
L21SP5_RS07275	COG0616	signal peptide processing
L21SP5_RS07280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L21SP5_RS07280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L21SP5_RS07290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L21SP5_RS07310	COG2003	Belongs to the UPF0758 family
L21SP5_RS07320	COG0268	Binds directly to 16S ribosomal RNA
L21SP5_RS07335	COG3385	transposase activity
L21SP5_RS07390	COG0587	DNA-directed DNA polymerase activity
L21SP5_RS07420	COG0446	pyridine nucleotide-disulphide oxidoreductase
L21SP5_RS07430	COG1489	DNA binding
L21SP5_RS07440	COG2814	Major facilitator Superfamily
L21SP5_RS07445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP5_RS07460	COG2001	Belongs to the MraZ family
L21SP5_RS07465	COG0275	rRNA processing
L21SP5_RS07475	COG0768	penicillin binding
L21SP5_RS07480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L21SP5_RS07485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L21SP5_RS07490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L21SP5_RS07495	COG0772	Belongs to the SEDS family
L21SP5_RS07500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L21SP5_RS07505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L21SP5_RS07520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L21SP5_RS07525	COG1610	YqeY-like protein
L21SP5_RS07530	COG0596	Alpha beta hydrolase
L21SP5_RS07535	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP5_RS07550	COG3958	Transketolase
L21SP5_RS07555	COG3959	Transketolase, thiamine diphosphate binding domain
L21SP5_RS07585	COG0811	peptide transport
L21SP5_RS07595	COG0252	asparaginase activity
L21SP5_RS07600	COG0084	hydrolase, TatD family'
L21SP5_RS07605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L21SP5_RS07605	COG0758	DNA mediated transformation
L21SP5_RS07610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L21SP5_RS07630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L21SP5_RS07645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L21SP5_RS07655	COG5002	protein histidine kinase activity
L21SP5_RS07655	COG5000	phosphorelay sensor kinase activity
L21SP5_RS07665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L21SP5_RS07680	COG0527	aspartate kinase activity
L21SP5_RS07680	COG0460	homoserine dehydrogenase
L21SP5_RS07685	COG2873	o-acetylhomoserine
L21SP5_RS07690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L21SP5_RS07695	COG0460	homoserine dehydrogenase
L21SP5_RS07700	COG1410	methionine synthase
L21SP5_RS07700	COG0646	methionine synthase
L21SP5_RS07705	COG4989	oxidoreductase activity
L21SP5_RS07745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS07775	COG0778	Nitroreductase
L21SP5_RS07780	COG2217	Heavy metal translocating P-type atpase
L21SP5_RS07825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
L21SP5_RS07825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
L21SP5_RS07845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L21SP5_RS07860	COG0662	Cupin 2, conserved barrel domain protein
L21SP5_RS07860	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
L21SP5_RS07890	COG2183	response to ionizing radiation
L21SP5_RS07910	COG3328	transposase activity
L21SP5_RS07930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L21SP5_RS07940	COG1979	alcohol dehydrogenase
L21SP5_RS07970	COG1418	mRNA catabolic process
L21SP5_RS07975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP5_RS07990	COG2301	Belongs to the HpcH HpaI aldolase family
L21SP5_RS08005	COG0534	Mate efflux family protein
L21SP5_RS08015	COG1342	Belongs to the UPF0251 family
L21SP5_RS08020	COG3206	protein involved in exopolysaccharide biosynthesis
L21SP5_RS08020	COG0489	protein tyrosine kinase activity
L21SP5_RS08040	COG0747	negative chemotaxis
L21SP5_RS08050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L21SP5_RS08050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L21SP5_RS08055	COG1619	proteins homologs of microcin C7 resistance protein MccF
L21SP5_RS08060	COG0792	nuclease activity
L21SP5_RS08070	COG0386	Belongs to the glutathione peroxidase family
L21SP5_RS08095	COG4771	TonB-dependent receptor
L21SP5_RS08100	COG0156	8-amino-7-oxononanoate synthase activity
L21SP5_RS08110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L21SP5_RS08120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L21SP5_RS08150	COG0254	rRNA binding
L21SP5_RS08160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L21SP5_RS08175	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L21SP5_RS08200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L21SP5_RS08230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L21SP5_RS08235	COG0545	Peptidyl-prolyl cis-trans isomerase
L21SP5_RS08240	COG1830	Aldolase
L21SP5_RS08255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L21SP5_RS08260	COG3591	Belongs to the peptidase S1B family
L21SP5_RS08295	COG0217	transcriptional regulatory protein
L21SP5_RS08300	COG2986	histidine ammonia-lyase
L21SP5_RS08325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L21SP5_RS08330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L21SP5_RS08335	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L21SP5_RS08340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L21SP5_RS08340	COG0512	Glutamine amidotransferase of anthranilate synthase
L21SP5_RS08345	COG1181	Belongs to the D-alanine--D-alanine ligase family
L21SP5_RS08360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L21SP5_RS08365	COG2205	protein histidine kinase activity
L21SP5_RS08365	COG0784	Response regulator, receiver
L21SP5_RS08385	COG0071	Belongs to the small heat shock protein (HSP20) family
L21SP5_RS08400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L21SP5_RS08420	COG2205	protein histidine kinase activity
L21SP5_RS08420	COG3437	response regulator, receiver
L21SP5_RS08420	COG3850	Histidine kinase
L21SP5_RS08420	COG4999	Histidine kinase
L21SP5_RS08430	COG0577	efflux transmembrane transporter activity
L21SP5_RS08430	COG1136	(ABC) transporter
L21SP5_RS08445	COG0681	Belongs to the peptidase S26 family
L21SP5_RS08450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L21SP5_RS08455	COG1566	PFAM secretion protein HlyD family protein
L21SP5_RS08510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L21SP5_RS08520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L21SP5_RS08560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L21SP5_RS08575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L21SP5_RS08580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L21SP5_RS08585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L21SP5_RS08590	COG0131	Imidazoleglycerol-phosphate dehydratase
L21SP5_RS08590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L21SP5_RS08600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L21SP5_RS08605	COG0107	imidazoleglycerol-phosphate synthase activity
L21SP5_RS08610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L21SP5_RS08610	COG0140	phosphoribosyl-ATP diphosphatase activity
L21SP5_RS08635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L21SP5_RS08640	COG1214	PFAM Peptidase M22, glycoprotease
L21SP5_RS08655	COG0047	phosphoribosylformylglycinamidine synthase activity
L21SP5_RS08665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L21SP5_RS08670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L21SP5_RS08700	COG1716	ATPase activity
L21SP5_RS08700	COG1131	(ABC) transporter
L21SP5_RS08700	COG0842	Transport permease protein
L21SP5_RS08715	COG0671	phosphoesterase, PA-phosphatase related
L21SP5_RS08720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L21SP5_RS08725	COG0563	adenylate kinase activity
L21SP5_RS08730	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L21SP5_RS08735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L21SP5_RS08750	COG2259	Doxx family
L21SP5_RS08760	COG0668	transmembrane transport
L21SP5_RS08765	COG0598	Magnesium transport protein CorA
L21SP5_RS08790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L21SP5_RS08795	COG1575	Belongs to the MenA family. Type 1 subfamily
L21SP5_RS08810	COG1183	phosphatidylcholine synthase activity
L21SP5_RS08815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L21SP5_RS08820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L21SP5_RS08825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L21SP5_RS08840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L21SP5_RS08845	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L21SP5_RS08860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L21SP5_RS08890	COG2972	Histidine kinase
L21SP5_RS08905	COG0632	four-way junction helicase activity
L21SP5_RS08920	COG1271	oxidase subunit
L21SP5_RS08935	COG1053	succinate dehydrogenase
L21SP5_RS08945	COG1988	membrane-bound metal-dependent
L21SP5_RS08965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L21SP5_RS08980	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
L21SP5_RS09015	COG0006	proline dipeptidase activity
L21SP5_RS09020	COG1355	regulation of microtubule-based process
L21SP5_RS09045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L21SP5_RS09050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L21SP5_RS09055	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
L21SP5_RS09060	COG1428	Deoxynucleoside kinase
L21SP5_RS09080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L21SP5_RS09085	COG0494	nUDIX hydrolase
L21SP5_RS09115	COG3046	protein related to deoxyribodipyrimidine photolyase
L21SP5_RS09130	COG1595	DNA-templated transcription, initiation
L21SP5_RS09165	COG2304	oxidoreductase activity
L21SP5_RS09170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L21SP5_RS09175	COG0252	asparaginase activity
L21SP5_RS09180	COG1045	serine acetyltransferase
L21SP5_RS09215	COG4771	TonB-dependent receptor
L21SP5_RS09235	COG2197	response regulator
L21SP5_RS09245	COG4771	TonB-dependent receptor
L21SP5_RS09300	COG1752	Esterase of the alpha-beta hydrolase superfamily
L21SP5_RS09325	COG3328	transposase activity
L21SP5_RS09335	COG2815	serine threonine protein kinase
L21SP5_RS09335	COG0515	serine threonine protein kinase
L21SP5_RS09365	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS09370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L21SP5_RS09385	COG0126	phosphoglycerate kinase activity
L21SP5_RS09390	COG0470	DNA polymerase III
L21SP5_RS09395	COG1774	PSP1 C-terminal conserved region
L21SP5_RS09405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L21SP5_RS09415	COG0489	protein tyrosine kinase activity
L21SP5_RS09425	COG2204	response regulator
L21SP5_RS09430	COG0802	atpase or kinase
L21SP5_RS09445	COG0557	exoribonuclease II activity
L21SP5_RS09455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L21SP5_RS09460	COG0017	Asparaginyl-tRNA synthetase
L21SP5_RS09475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP5_RS09480	COG1078	dGTPase activity
L21SP5_RS09485	COG0779	Required for maturation of 30S ribosomal subunits
L21SP5_RS09490	COG0195	Participates in both transcription termination and antitermination
L21SP5_RS09495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L21SP5_RS09495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L21SP5_RS09500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L21SP5_RS09505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L21SP5_RS09510	COG1968	undecaprenyl-diphosphatase activity
L21SP5_RS09520	COG2177	Part of the ABC transporter FtsEX involved in
L21SP5_RS09525	COG0583	DNA-binding transcription factor activity
L21SP5_RS09535	COG5002	protein histidine kinase activity
L21SP5_RS09650	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
L21SP5_RS09660	COG1216	Glycosyl transferase, family 2
L21SP5_RS09660	COG0463	Glycosyl transferase, family 2
L21SP5_RS09670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L21SP5_RS09675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP5_RS09680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L21SP5_RS09685	COG4106	trans-aconitate 2-methyltransferase activity
L21SP5_RS09705	COG1487	ribonuclease activity
L21SP5_RS09715	COG2205	protein histidine kinase activity
L21SP5_RS09715	COG0784	Response regulator, receiver
L21SP5_RS09720	COG1595	DNA-templated transcription, initiation
L21SP5_RS09750	COG5002	protein histidine kinase activity
L21SP5_RS09785	COG2356	endonuclease I
L21SP5_RS09800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L21SP5_RS09800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L21SP5_RS09810	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L21SP5_RS09815	COG0084	hydrolase, TatD family'
L21SP5_RS09820	COG0436	Aminotransferase
L21SP5_RS09825	COG1381	Involved in DNA repair and RecF pathway recombination
L21SP5_RS09835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L21SP5_RS09850	COG0826	peptidase U32
L21SP5_RS09855	COG0859	PFAM glycosyl transferase family 9
L21SP5_RS09860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L21SP5_RS09865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L21SP5_RS09875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP5_RS09885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L21SP5_RS09890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L21SP5_RS09895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L21SP5_RS09900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L21SP5_RS09905	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L21SP5_RS09910	COG0356	it plays a direct role in the translocation of protons across the membrane
L21SP5_RS09955	COG1595	DNA-templated transcription, initiation
L21SP5_RS09960	COG2205	protein histidine kinase activity
L21SP5_RS09960	COG0784	Response regulator, receiver
L21SP5_RS09970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L21SP5_RS09975	COG0006	proline dipeptidase activity
L21SP5_RS09985	COG2356	endonuclease I
L21SP5_RS09990	COG2985	domain, Protein
L21SP5_RS09990	COG0490	domain, Protein
L21SP5_RS09995	COG0640	Transcriptional regulator
L21SP5_RS10000	COG1217	gtp-binding protein TYPA
L21SP5_RS10020	COG3604	Transcriptional regulator
L21SP5_RS10025	COG1490	D-aminoacyl-tRNA deacylase activity
L21SP5_RS10030	COG1694	Mazg nucleotide pyrophosphohydrolase
L21SP5_RS10050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP5_RS10055	COG0416	fatty acid biosynthetic process
L21SP5_RS10090	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
L21SP5_RS10100	COG0322	excinuclease ABC activity
L21SP5_RS10105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L21SP5_RS10110	COG0445	tRNA wobble uridine modification
L21SP5_RS10115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L21SP5_RS10145	COG0756	dUTP diphosphatase activity
L21SP5_RS10160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L21SP5_RS10170	COG1959	2 iron, 2 sulfur cluster binding
L21SP5_RS10190	COG0463	Glycosyl transferase, family 2
L21SP5_RS10195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L21SP5_RS10200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L21SP5_RS10205	COG0527	aspartate kinase activity
L21SP5_RS10210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
L21SP5_RS10220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
L21SP5_RS10235	COG2996	Protein conserved in bacteria
L21SP5_RS10270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L21SP5_RS10275	COG1162	GTPase activity
L21SP5_RS10285	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L21SP5_RS10285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L21SP5_RS10295	COG0596	Alpha beta hydrolase
L21SP5_RS10355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L21SP5_RS10445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP5_RS10450	COG1088	dTDP-glucose 4,6-dehydratase activity
L21SP5_RS10455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L21SP5_RS10460	COG0110	maltose O-acetyltransferase activity
L21SP5_RS10515	COG0726	polysaccharide deacetylase
L21SP5_RS10580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L21SP5_RS10655	COG2205	protein histidine kinase activity
L21SP5_RS10655	COG0784	Response regulator, receiver
L21SP5_RS10690	COG3787	Belongs to the UPF0306 family
L21SP5_RS10695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L21SP5_RS10700	COG0589	response to stress
L21SP5_RS10710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L21SP5_RS10730	COG1484	DNA-dependent DNA replication
L21SP5_RS10770	COG0671	phosphoesterase, PA-phosphatase related
L21SP5_RS10775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L21SP5_RS10780	COG0463	Glycosyl transferase, family 2
L21SP5_RS10785	COG0784	Response regulator, receiver
L21SP5_RS10785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L21SP5_RS10785	COG2198	Histidine kinase
L21SP5_RS10785	COG2205	protein histidine kinase activity
L21SP5_RS10800	COG0358	DNA primase activity
L21SP5_RS10810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L21SP5_RS10815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L21SP5_RS10835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L21SP5_RS10840	COG1335	isochorismatase
L21SP5_RS10855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L21SP5_RS10875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L21SP5_RS10890	COG2852	Protein conserved in bacteria
L21SP5_RS10895	COG2852	Protein conserved in bacteria
L21SP5_RS10905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L21SP5_RS10910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L21SP5_RS10920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L21SP5_RS10935	COG1192	Involved in chromosome partitioning
L21SP5_RS10955	COG0328	RNA-DNA hybrid ribonuclease activity
L21SP5_RS10960	COG0731	radical SAM domain protein
L21SP5_RS10960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L21SP5_RS10975	COG2703	oxygen carrier activity
L21SP5_RS10980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L21SP5_RS11020	COG0719	Fe-S assembly protein
L21SP5_RS11025	COG0396	ATPase activity
L21SP5_RS11030	COG0719	Fe-S assembly protein
L21SP5_RS11035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L21SP5_RS11040	COG2166	iron-sulfur cluster assembly
L21SP5_RS11045	COG2151	metal-sulfur cluster biosynthetic enzyme
L21SP5_RS11070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L21SP5_RS11080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L21SP5_RS11085	COG0509	glycine decarboxylation via glycine cleavage system
L21SP5_RS11090	COG5002	protein histidine kinase activity
L21SP5_RS11100	COG4191	Histidine kinase
L21SP5_RS11115	COG0180	Tryptophanyl-tRNA synthetase
L21SP5_RS11145	COG0739	heme binding
L21SP5_RS11150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L21SP5_RS11155	COG0750	zinc metalloprotease
L21SP5_RS11160	COG2885	chlorophyll binding
L21SP5_RS11165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L21SP5_RS11170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L21SP5_RS11175	COG0284	orotidine-5'-phosphate decarboxylase activity
L21SP5_RS11190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L21SP5_RS11190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L21SP5_RS11195	COG1131	(ABC) transporter
L21SP5_RS11210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L21SP5_RS11210	COG1648	precorrin-2 dehydrogenase activity
L21SP5_RS11225	COG1956	GAF domain-containing protein
L21SP5_RS11245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L21SP5_RS11255	COG0730	response to heat
L21SP5_RS11265	COG1473	amidohydrolase
L21SP5_RS11280	COG0163	prenyltransferase activity
L21SP5_RS11305	COG1320	monovalent cation:proton antiporter activity
L21SP5_RS11310	COG2212	antiporter activity
L21SP5_RS11315	COG1863	multisubunit Na H antiporter MnhE subunit
L21SP5_RS11320	COG0651	ATP synthesis coupled electron transport
L21SP5_RS11325	COG1006	Multisubunit Na H antiporter MnhC subunit
L21SP5_RS11330	COG2111	Na H antiporter
L21SP5_RS11335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L21SP5_RS11335	COG2111	Na H antiporter
L21SP5_RS11355	COG0514	ATP-dependent DNA helicase (RecQ)
L21SP5_RS11360	COG0517	IMP dehydrogenase activity
L21SP5_RS11360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L21SP5_RS11375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP5_RS11390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L21SP5_RS11390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L21SP5_RS11410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L21SP5_RS11420	COG0481	GTPase activity
L21SP5_RS11425	COG0589	response to stress
L21SP5_RS11445	COG0686	Belongs to the AlaDH PNT family
L21SP5_RS11455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L21SP5_RS11460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L21SP5_RS11465	COG0052	Belongs to the universal ribosomal protein uS2 family
L21SP5_RS11470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L21SP5_RS11475	COG0528	UMP kinase activity
L21SP5_RS11480	COG0233	cytoplasmic translational termination
L21SP5_RS11485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L21SP5_RS11490	COG1360	Flagellar Motor Protein
L21SP5_RS11505	COG0594	ribonuclease P activity
L21SP5_RS11510	COG0793	Belongs to the peptidase S41A family
L21SP5_RS11520	COG1266	CAAX protease self-immunity
L21SP5_RS11525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L21SP5_RS11550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L21SP5_RS11570	COG1011	Hydrolase
L21SP5_RS11585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L21SP5_RS11590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L21SP5_RS11595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L21SP5_RS11605	COG1695	Transcriptional regulator
L21SP5_RS11620	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L21SP5_RS11630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L21SP5_RS11630	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L21SP5_RS11640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L21SP5_RS11645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L21SP5_RS11650	COG0297	glycogen (starch) synthase activity
L21SP5_RS11660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L21SP5_RS11685	COG1127	ABC transporter
L21SP5_RS11690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L21SP5_RS11710	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L21SP5_RS11755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L21SP5_RS11755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP5_RS11770	COG0529	Catalyzes the synthesis of activated sulfate
L21SP5_RS11790	COG4585	Histidine kinase
L21SP5_RS11830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L21SP5_RS11835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L21SP5_RS11840	COG0571	ribonuclease III activity
L21SP5_RS11865	COG5002	protein histidine kinase activity
L21SP5_RS11865	COG2198	Histidine kinase
L21SP5_RS11865	COG0784	Response regulator, receiver
L21SP5_RS11870	COG2211	Major facilitator Superfamily
L21SP5_RS11910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L21SP5_RS11920	COG0402	S-adenosylhomocysteine deaminase activity
L21SP5_RS11935	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L21SP5_RS11950	COG0423	glycine-tRNA ligase activity
L21SP5_RS11980	COG3409	Peptidoglycan-binding domain 1 protein
L21SP5_RS11980	COG0793	Belongs to the peptidase S41A family
L21SP5_RS12015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L21SP5_RS12020	COG0537	adenosine 5'-monophosphoramidase activity
L21SP5_RS12030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L21SP5_RS12035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L21SP5_RS12040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L21SP5_RS12040	COG1754	DNA topoisomerase type I activity
L21SP5_RS12060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP5_RS12170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L21SP5_RS12170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP5_RS12190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L21SP5_RS12195	COG0606	chelatase, subunit chli
L21SP5_RS12240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L21SP5_RS12250	COG0228	four-way junction DNA binding
L21SP5_RS12255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L21SP5_RS12280	COG1722	exodeoxyribonuclease VII activity
L21SP5_RS12310	COG0443	Heat shock 70 kDa protein
L21SP5_RS12315	COG1663	tetraacyldisaccharide 4'-kinase activity
L21SP5_RS12320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L21SP5_RS12320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L21SP5_RS12325	COG2890	protein-(glutamine-N5) methyltransferase activity
L21SP5_RS12330	COG2137	regulation of response to DNA damage stimulus
L21SP5_RS12335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L21SP5_RS12345	COG1393	Belongs to the ArsC family
L21SP5_RS12350	COG1024	Enoyl-CoA hydratase
L21SP5_RS12365	COG4771	TonB-dependent receptor
L21SP5_RS12400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L21SP5_RS12415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L21SP5_RS12430	COG0321	lipoyl(octanoyl) transferase activity
L21SP5_RS12435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L21SP5_RS12440	COG0045	succinate-CoA ligase (ADP-forming) activity
L21SP5_RS12465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L21SP5_RS12465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L21SP5_RS12475	COG2086	electron transfer activity
L21SP5_RS12480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L21SP5_RS12490	COG3291	Pkd domain containing protein
L21SP5_RS12505	COG4249	Peptidase C14 caspase catalytic subunit p20
L21SP5_RS12505	COG2319	Wd-40 repeat
L21SP5_RS12525	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L21SP5_RS12530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L21SP5_RS12550	COG0459	protein refolding
L21SP5_RS12555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L21SP5_RS12560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
L21SP5_RS12575	COG2205	protein histidine kinase activity
L21SP5_RS12590	COG0493	'glutamate synthase
L21SP5_RS12645	COG1054	Belongs to the UPF0176 family
L21SP5_RS12650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L21SP5_RS12655	COG0798	PFAM Bile acid sodium symporter
L21SP5_RS12670	COG4221	oxidoreductase activity
L21SP5_RS12675	COG4221	oxidoreductase activity
L21SP5_RS12680	COG1309	transcriptional regulator
L21SP5_RS12720	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
L21SP5_RS12725	COG0709	Synthesizes selenophosphate from selenide and ATP
L21SP5_RS12735	COG0697	spore germination
L21SP5_RS12765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L21SP5_RS12785	COG2205	protein histidine kinase activity
L21SP5_RS12805	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L21SP5_RS12815	COG2181	nitrate reductase activity
L21SP5_RS12815	COG0247	lactate metabolic process
L21SP5_RS12830	COG0667	Aldo Keto reductase
L21SP5_RS12835	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L21SP5_RS12840	COG2086	electron transfer activity
L21SP5_RS12845	COG1960	acyl-CoA dehydrogenase activity
L21SP5_RS12850	COG0183	Belongs to the thiolase family
L21SP5_RS12855	COG1250	3-hydroxyacyl-CoA dehydrogenase
L21SP5_RS12860	COG1024	Enoyl-CoA hydratase
L21SP5_RS12875	COG0513	Belongs to the DEAD box helicase family
L21SP5_RS12895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L21SP5_RS12905	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L21SP5_RS12910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L21SP5_RS12920	COG0009	L-threonylcarbamoyladenylate synthase
L21SP5_RS12925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L21SP5_RS12930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L21SP5_RS12935	COG1185	polyribonucleotide nucleotidyltransferase activity
L21SP5_RS12940	COG2333	competence protein COMEC
L21SP5_RS12940	COG0658	competence protein
L21SP5_RS12955	COG0546	phosphoglycolate phosphatase activity
L21SP5_RS12965	COG2972	Histidine kinase
L21SP5_RS12970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L21SP5_RS12980	COG1435	thymidine kinase activity
L21SP5_RS12985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L21SP5_RS12995	COG2078	PFAM AMMECR1 domain protein
L21SP5_RS13005	COG1355	regulation of microtubule-based process
L21SP5_RS13020	COG2202	Pas domain
L21SP5_RS13020	COG2205	protein histidine kinase activity
L21SP5_RS13040	COG0592	DNA-directed DNA polymerase activity
L21SP5_RS13055	COG0138	bifunctional purine biosynthesis protein purh
L21SP5_RS13060	COG1077	Cell shape determining protein MreB Mrl
L21SP5_RS13075	COG0768	penicillin binding
L21SP5_RS13080	COG0772	Belongs to the SEDS family
L21SP5_RS13085	COG1509	lysine 2,3-aminomutase activity
L21SP5_RS13100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L21SP5_RS13105	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L21SP5_RS13110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS13120	COG0009	L-threonylcarbamoyladenylate synthase
L21SP5_RS13125	COG2171	N-acyltransferase activity
L21SP5_RS13130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L21SP5_RS13130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L21SP5_RS13135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L21SP5_RS13140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS13155	COG2135	peptidase activity
L21SP5_RS13160	COG1253	flavin adenine dinucleotide binding
L21SP5_RS13170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L21SP5_RS13195	COG3034	peptidoglycan biosynthetic process
L21SP5_RS13220	COG0242	peptide deformylase activity
L21SP5_RS13225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L21SP5_RS13245	COG0450	alkyl hydroperoxide reductase
L21SP5_RS13250	COG0783	Belongs to the Dps family
L21SP5_RS13280	COG3537	Alpha-1,2-mannosidase
L21SP5_RS13295	COG1863	multisubunit Na H antiporter MnhE subunit
L21SP5_RS13315	COG2111	Na H antiporter
L21SP5_RS13320	COG1006	Multisubunit Na H antiporter MnhC subunit
L21SP5_RS13325	COG0651	ATP synthesis coupled electron transport
L21SP5_RS13330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
L21SP5_RS13335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L21SP5_RS13340	COG0649	NAD binding
L21SP5_RS13340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L21SP5_RS13345	COG0649	NAD binding
L21SP5_RS13355	COG0167	dihydroorotate dehydrogenase activity
L21SP5_RS13385	COG2080	2 iron, 2 sulfur cluster binding
L21SP5_RS13385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L21SP5_RS13400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L21SP5_RS13415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L21SP5_RS13415	COG0493	'glutamate synthase
L21SP5_RS13430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L21SP5_RS13435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L21SP5_RS13440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L21SP5_RS13445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
L21SP5_RS13445	COG3608	succinylglutamate desuccinylase aspartoacylase
L21SP5_RS13450	COG0590	tRNA wobble adenosine to inosine editing
L21SP5_RS13455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L21SP5_RS13460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L21SP5_RS13460	COG0512	Glutamine amidotransferase of anthranilate synthase
L21SP5_RS13465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L21SP5_RS13470	COG0134	indole-3-glycerol-phosphate synthase activity
L21SP5_RS13475	COG0135	phosphoribosylanthranilate isomerase activity
L21SP5_RS13480	COG0133	tryptophan synthase activity
L21SP5_RS13485	COG0159	tryptophan synthase activity
L21SP5_RS13505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L21SP5_RS13510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L21SP5_RS13515	COG0287	Prephenate dehydrogenase
L21SP5_RS13520	COG0436	Aminotransferase
L21SP5_RS13530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L21SP5_RS13535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L21SP5_RS13540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L21SP5_RS13545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L21SP5_RS13550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L21SP5_RS13555	COG1309	transcriptional regulator
L21SP5_RS13575	COG1131	(ABC) transporter
L21SP5_RS13580	COG1131	(ABC) transporter
L21SP5_RS13590	COG0842	Transport permease protein
L21SP5_RS13595	COG0842	Transport permease protein
L21SP5_RS13610	COG1501	Belongs to the glycosyl hydrolase 31 family
L21SP5_RS13620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L21SP5_RS13625	COG0366	Alpha amylase catalytic
L21SP5_RS13640	COG1554	hydrolase, family 65, central catalytic
L21SP5_RS13645	COG0366	Alpha amylase catalytic
L21SP5_RS13655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L21SP5_RS13660	COG1629	transport
L21SP5_RS13660	COG4206	TonB-dependent receptor
L21SP5_RS13675	COG4206	TonB-dependent receptor
L21SP5_RS13685	COG3530	Putative quorum-sensing-regulated virulence factor
L21SP5_RS13735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L21SP5_RS13790	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L21SP5_RS13800	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L21SP5_RS13815	COG0573	inorganic phosphate transmembrane transporter activity
L21SP5_RS13830	COG2197	response regulator
L21SP5_RS13845	COG3328	transposase activity
L21SP5_RS13855	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP5_RS13865	COG2814	Major facilitator Superfamily
L21SP5_RS13885	COG0702	epimerase
L21SP5_RS13890	COG4206	TonB-dependent receptor
L21SP5_RS13890	COG1629	transport
L21SP5_RS13910	COG1752	Esterase of the alpha-beta hydrolase superfamily
L21SP5_RS13915	COG1525	nuclease
L21SP5_RS13915	COG0737	Belongs to the 5'-nucleotidase family
L21SP5_RS13915	COG4085	toxin activity
L21SP5_RS13920	COG0840	transmembrane signaling receptor activity
L21SP5_RS14000	COG2096	Adenosyltransferase
L21SP5_RS14015	COG0714	Associated with various cellular activities
L21SP5_RS14030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L21SP5_RS14035	COG0517	IMP dehydrogenase activity
L21SP5_RS14035	COG0516	GMP reductase activity
L21SP5_RS14040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L21SP5_RS14050	COG3655	Transcriptional regulator
L21SP5_RS14055	COG0612	Peptidase, M16
L21SP5_RS14060	COG0612	Peptidase, M16
L21SP5_RS14090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L21SP5_RS14105	COG0101	tRNA pseudouridine synthase activity
L21SP5_RS14110	COG0714	Associated with various cellular activities
L21SP5_RS14125	COG2304	oxidoreductase activity
L21SP5_RS14155	COG3275	phosphorelay sensor kinase activity
L21SP5_RS14160	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS14180	COG3426	butyrate kinase activity
L21SP5_RS14185	COG1960	acyl-CoA dehydrogenase activity
L21SP5_RS14190	COG1703	isobutyryl-CoA mutase activity
L21SP5_RS14190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L21SP5_RS14190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L21SP5_RS14195	COG3426	butyrate kinase activity
L21SP5_RS14205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L21SP5_RS14210	COG2431	L-lysine efflux transmembrane transporter activity
L21SP5_RS14260	COG0840	transmembrane signaling receptor activity
L21SP5_RS14270	COG0277	FAD linked oxidase domain protein
L21SP5_RS14270	COG0247	lactate metabolic process
L21SP5_RS14275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L21SP5_RS14280	COG0018	arginyl-trna synthetase
L21SP5_RS14285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L21SP5_RS14310	COG0697	spore germination
L21SP5_RS14315	COG0280	phosphate acetyltransferase
L21SP5_RS14320	COG1250	3-hydroxyacyl-CoA dehydrogenase
L21SP5_RS14325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L21SP5_RS14330	COG0280	phosphate acetyltransferase
L21SP5_RS14335	COG0280	phosphate acetyltransferase
L21SP5_RS14340	COG3426	butyrate kinase activity
L21SP5_RS14345	COG0739	heme binding
L21SP5_RS14355	COG0840	transmembrane signaling receptor activity
L21SP5_RS14355	COG0840	transmembrane signaling receptor activity
L21SP5_RS14375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L21SP5_RS14380	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
L21SP5_RS14380	COG0778	Nitroreductase
L21SP5_RS14400	COG0534	Mate efflux family protein
L21SP5_RS14435	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L21SP5_RS14440	COG0596	Alpha beta hydrolase
L21SP5_RS14450	COG0572	uridine kinase
L21SP5_RS14455	COG1482	cell wall glycoprotein biosynthetic process
L21SP5_RS14465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L21SP5_RS14470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L21SP5_RS14475	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L21SP5_RS14480	COG0193	aminoacyl-tRNA hydrolase activity
L21SP5_RS14495	COG0519	Catalyzes the synthesis of GMP from XMP
L21SP5_RS14495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L21SP5_RS14500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L21SP5_RS14520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L21SP5_RS14540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L21SP5_RS14545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L21SP5_RS14550	COG0674	pyruvate-flavodoxin oxidoreductase activity
L21SP5_RS14550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L21SP5_RS14555	COG1013	pyruvate-flavodoxin oxidoreductase activity
L21SP5_RS14560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L21SP5_RS14565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L21SP5_RS14570	COG3063	Type IV pilus biogenesis stability protein PilW
L21SP5_RS14575	COG1506	peptidase
L21SP5_RS14575	COG0823	Involved in the tonB-independent uptake of proteins
L21SP5_RS14595	COG0731	radical SAM domain protein
L21SP5_RS14595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L21SP5_RS14600	COG0039	L-malate dehydrogenase activity
L21SP5_RS14605	COG0039	L-malate dehydrogenase activity
L21SP5_RS14610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L21SP5_RS14715	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP5_RS14755	COG0426	domain, Protein
L21SP5_RS14765	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
L21SP5_RS14770	COG0540	Belongs to the ATCase OTCase family
L21SP5_RS14780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L21SP5_RS14795	COG3328	transposase activity
L21SP5_RS14800	COG2095	MarC family integral membrane protein
L21SP5_RS14805	COG1160	GTP binding
L21SP5_RS14810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L21SP5_RS14820	COG0488	(ABC) transporter
L21SP5_RS14870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L21SP5_RS14875	COG4942	peptidase
L21SP5_RS14895	COG3291	Pkd domain containing protein
L21SP5_RS14905	COG4221	oxidoreductase activity
L21SP5_RS14915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L21SP5_RS14920	COG2226	methyltransferase
L21SP5_RS14930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
L21SP5_RS14940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L21SP5_RS14950	COG0733	neurotransmitter:sodium symporter activity
L21SP5_RS14960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L21SP5_RS14965	COG0049	tRNA binding
L21SP5_RS14970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP5_RS14975	COG0051	transcription antitermination factor activity, RNA binding
L21SP5_RS14980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L21SP5_RS14985	COG0088	Forms part of the polypeptide exit tunnel
L21SP5_RS14990	COG0089	rRNA binding
L21SP5_RS14995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L21SP5_RS15000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L21SP5_RS15005	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L21SP5_RS15010	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L21SP5_RS15015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L21SP5_RS15020	COG0255	Belongs to the universal ribosomal protein uL29 family
L21SP5_RS15025	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L21SP5_RS15030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L21SP5_RS15035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L21SP5_RS15040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L21SP5_RS15045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L21SP5_RS15050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L21SP5_RS15055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L21SP5_RS15065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L21SP5_RS15070	COG1841	ribosomal large subunit assembly
L21SP5_RS15075	COG0200	Binds to the 23S rRNA
L21SP5_RS15085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L21SP5_RS15090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L21SP5_RS15095	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L21SP5_RS15100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L21SP5_RS15105	COG0202	RNA polymerase activity
L21SP5_RS15110	COG0203	ribosomal protein L17
L21SP5_RS15115	COG0148	phosphopyruvate hydratase activity
L21SP5_RS15120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
L21SP5_RS15125	COG3292	Two component regulator propeller
L21SP5_RS15125	COG2205	protein histidine kinase activity
L21SP5_RS15125	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS15130	COG0674	pyruvate-flavodoxin oxidoreductase activity
L21SP5_RS15130	COG1013	pyruvate-flavodoxin oxidoreductase activity
L21SP5_RS15130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L21SP5_RS15130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L21SP5_RS15180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L21SP5_RS15185	COG1027	Aspartate ammonia-lyase
L21SP5_RS15190	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS15195	COG5002	protein histidine kinase activity
L21SP5_RS15210	COG4771	TonB-dependent receptor
L21SP5_RS15240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L21SP5_RS15245	COG0497	DNA recombination
L21SP5_RS15270	COG0156	8-amino-7-oxononanoate synthase activity
L21SP5_RS15275	COG4771	TonB-dependent receptor
L21SP5_RS15290	COG0517	IMP dehydrogenase activity
L21SP5_RS15290	COG0617	tRNA 3'-terminal CCA addition
L21SP5_RS15290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L21SP5_RS15310	COG3328	transposase activity
L21SP5_RS15315	COG2201	protein-glutamate methylesterase activity
L21SP5_RS15320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
L21SP5_RS15345	COG0835	chemotaxis
L21SP5_RS15350	COG0643	Histidine kinase
L21SP5_RS15350	COG2198	Histidine kinase
L21SP5_RS15355	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS15370	COG0784	Response regulator, receiver
L21SP5_RS15370	COG2205	protein histidine kinase activity
L21SP5_RS15375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L21SP5_RS15390	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
L21SP5_RS15405	COG0302	gtp cyclohydrolase
L21SP5_RS15415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L21SP5_RS15420	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP5_RS15430	COG2205	protein histidine kinase activity
L21SP5_RS15430	COG0784	Response regulator, receiver
L21SP5_RS15445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L21SP5_RS15520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP5_RS15555	COG0483	inositol monophosphate 1-phosphatase activity
L21SP5_RS15560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP5_RS15570	COG3040	lipid binding
L21SP5_RS15575	COG0415	Belongs to the DNA photolyase family
L21SP5_RS15580	COG1090	epimerase
L21SP5_RS15620	COG3385	transposase activity
L21SP5_RS15675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L21SP5_RS15715	COG3385	transposase activity
L21SP5_RS15765	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L21SP5_RS15795	COG1401	restriction endodeoxyribonuclease activity
L21SP5_RS15860	COG2195	Cleaves the N-terminal amino acid of tripeptides
L21SP5_RS15865	COG0823	Involved in the tonB-independent uptake of proteins
L21SP5_RS15865	COG1506	peptidase
L21SP5_RS15930	COG2249	NAD(P)H dehydrogenase (quinone) activity
L21SP5_RS15950	COG1530	ribonuclease E activity
L21SP5_RS15955	COG0776	regulation of translation
L21SP5_RS15960	COG1194	a g-specific adenine glycosylase
L21SP5_RS15970	COG4535	Mg2 and Co2 transporter CorC
L21SP5_RS15985	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
L21SP5_RS15995	COG0012	GTP binding
L21SP5_RS16015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L21SP5_RS16020	COG1024	Enoyl-CoA hydratase
L21SP5_RS16025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP5_RS16045	COG0784	Response regulator, receiver
L21SP5_RS16045	COG2205	protein histidine kinase activity
L21SP5_RS16060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L21SP5_RS16080	COG2247	cell wall binding repeat
L21SP5_RS16080	COG2385	sporulation resulting in formation of a cellular spore
L21SP5_RS16085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP5_RS16095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L21SP5_RS16115	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP5_RS16120	COG2205	protein histidine kinase activity
L21SP5_RS16120	COG3437	response regulator, receiver
L21SP5_RS16120	COG3850	Histidine kinase
L21SP5_RS16120	COG4999	Histidine kinase
L21SP5_RS16130	COG3457	Alanine racemase
L21SP5_RS16190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L21SP5_RS16190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L21SP5_RS16195	COG0840	transmembrane signaling receptor activity
L21SP5_RS16200	COG0612	Peptidase, M16
L21SP5_RS16210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
L21SP5_RS16220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L21SP5_RS16285	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS16290	COG5002	protein histidine kinase activity
L21SP5_RS16295	COG0339	signal peptide processing
L21SP5_RS16325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L21SP5_RS16350	COG2226	methyltransferase
L21SP5_RS16355	COG1703	isobutyryl-CoA mutase activity
L21SP5_RS16365	COG0668	transmembrane transport
L21SP5_RS16375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS16380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L21SP5_RS16395	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP5_RS16400	COG0724	RNA recognition motif
L21SP5_RS16410	COG0840	transmembrane signaling receptor activity
L21SP5_RS16420	COG3852	Histidine kinase
L21SP5_RS16440	COG0673	inositol 2-dehydrogenase activity
L21SP5_RS16445	COG1216	Glycosyl transferase, family 2
L21SP5_RS16450	COG1760	l-serine dehydratase
L21SP5_RS16465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L21SP5_RS16470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L21SP5_RS16480	COG0305	Participates in initiation and elongation during chromosome replication
L21SP5_RS16485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L21SP5_RS16495	COG2198	Histidine kinase
L21SP5_RS16495	COG0784	Response regulator, receiver
L21SP5_RS16495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L21SP5_RS16495	COG2205	protein histidine kinase activity
L21SP5_RS16505	COG1477	protein flavinylation
L21SP5_RS16525	COG2076	Multidrug Resistance protein
L21SP5_RS16540	COG0346	lactoylglutathione lyase activity
L21SP5_RS16545	COG1272	protein, Hemolysin III
L21SP5_RS16580	COG1803	Methylglyoxal synthase
L21SP5_RS16595	COG1278	Cold shock
L21SP5_RS16600	COG4895	conserved protein (DUF2196)
L21SP5_RS16605	COG0513	Belongs to the DEAD box helicase family
L21SP5_RS16670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP5_RS16690	COG0179	Fumarylacetoacetate (FAA) hydrolase
L21SP5_RS16700	COG1030	water channel activity
L21SP5_RS16710	COG2234	aminopeptidase activity
L21SP5_RS16710	COG4935	Belongs to the peptidase S8 family
L21SP5_RS16730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L21SP5_RS16735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L21SP5_RS16735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
L21SP5_RS16755	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS16760	COG3275	phosphorelay sensor kinase activity
L21SP5_RS16775	COG0693	protein deglycase activity
L21SP5_RS16780	COG4191	Histidine kinase
L21SP5_RS16780	COG0784	Response regulator, receiver
L21SP5_RS16795	COG0538	isocitrate dehydrogenase activity
L21SP5_RS16805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L21SP5_RS16815	COG2884	Cell division ATP-binding protein ftsE
L21SP5_RS16825	COG0183	Belongs to the thiolase family
L21SP5_RS16830	COG2267	carboxylic ester hydrolase activity
L21SP5_RS16835	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP5_RS16840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP5_RS16855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP5_RS16880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
L21SP5_RS16885	COG0534	Mate efflux family protein
L21SP5_RS16905	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS16990	COG1518	maintenance of DNA repeat elements
L21SP5_RS17000	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
L21SP5_RS17005	COG3328	transposase activity
L21SP5_RS17010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L21SP5_RS17020	COG0514	ATP-dependent DNA helicase (RecQ)
L21SP5_RS17040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L21SP5_RS17045	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L21SP5_RS17050	COG0475	glutathione-regulated potassium exporter activity
L21SP5_RS17050	COG0569	domain protein
L21SP5_RS17060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L21SP5_RS17070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L21SP5_RS17095	COG0124	histidyl-tRNA synthetase
L21SP5_RS17100	COG2986	histidine ammonia-lyase
L21SP5_RS17105	COG0612	Peptidase, M16
L21SP5_RS17135	COG0667	Aldo Keto reductase
L21SP5_RS17150	COG2814	Major facilitator Superfamily
L21SP5_RS17150	COG0477	Major facilitator Superfamily
L21SP5_RS17180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L21SP5_RS17190	COG0681	Belongs to the peptidase S26 family
L21SP5_RS17195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L21SP5_RS17200	COG0339	signal peptide processing
L21SP5_RS17210	COG1252	NADH dehydrogenase
L21SP5_RS17230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L21SP5_RS17230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L21SP5_RS17235	COG0366	Alpha amylase catalytic
L21SP5_RS17240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L21SP5_RS17245	COG1295	ribonuclease BN
L21SP5_RS17260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L21SP5_RS17280	COG4974	Belongs to the 'phage' integrase family
L21SP5_RS17290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L21SP5_RS17295	COG0511	ligase activity, forming carbon-carbon bonds
L21SP5_RS17305	COG1505	serine-type exopeptidase activity
L21SP5_RS17310	COG0385	Bile acid
L21SP5_RS17330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L21SP5_RS17335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L21SP5_RS17345	COG0482	sulfurtransferase activity
L21SP5_RS17360	COG0175	sulfate reduction
L21SP5_RS17365	COG0175	sulfate reduction
L21SP5_RS17370	COG0432	Pfam Uncharacterised protein family UPF0047
L21SP5_RS17375	COG0123	including yeast histone deacetylase and acetoin utilization protein
L21SP5_RS17385	COG1366	Belongs to the anti-sigma-factor antagonist family
L21SP5_RS17390	COG0784	Response regulator, receiver
L21SP5_RS17390	COG2205	protein histidine kinase activity
L21SP5_RS17390	COG2198	Histidine kinase
L21SP5_RS17410	COG2885	chlorophyll binding
L21SP5_RS17415	COG3385	transposase activity
L21SP5_RS17425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L21SP5_RS17430	COG2045	Belongs to the ComB family
L21SP5_RS17455	COG0318	PFAM AMP-dependent synthetase and ligase
L21SP5_RS17465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L21SP5_RS17495	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L21SP5_RS17515	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L21SP5_RS17520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L21SP5_RS17530	COG3291	Pkd domain containing protein
L21SP5_RS17540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP5_RS17545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L21SP5_RS17550	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L21SP5_RS17555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L21SP5_RS17560	COG2814	Major facilitator Superfamily
L21SP5_RS17570	COG4771	TonB-dependent receptor
L21SP5_RS17615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L21SP5_RS17615	COG1845	cytochrome c oxidase, subunit III
L21SP5_RS17630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L21SP5_RS17640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L21SP5_RS17645	COG0805	protein transport
L21SP5_RS17650	COG0154	amidase activity
L21SP5_RS17660	COG3292	Two component regulator propeller
L21SP5_RS17660	COG2205	protein histidine kinase activity
L21SP5_RS17660	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS17685	COG1047	Peptidyl-prolyl cis-trans
L21SP5_RS17690	COG1301	dicarboxylic acid transport
L21SP5_RS17705	COG0693	protein deglycase activity
L21SP5_RS17710	COG0009	L-threonylcarbamoyladenylate synthase
L21SP5_RS17775	COG2361	Protein of unknown function DUF86
L21SP5_RS17825	COG4771	TonB-dependent receptor
L21SP5_RS17850	COG4206	TonB-dependent receptor
L21SP5_RS17860	COG0716	FMN binding
L21SP5_RS17870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L21SP5_RS17875	COG1132	(ABC) transporter
L21SP5_RS17880	COG1132	(ABC) transporter
L21SP5_RS17895	COG1131	(ABC) transporter
L21SP5_RS17905	COG2197	response regulator
L21SP5_RS17930	COG4680	protein conserved in bacteria
L21SP5_RS17940	COG3385	transposase activity
L21SP5_RS18005	COG3385	transposase activity
L21SP5_RS18035	COG3328	transposase activity
L21SP5_RS18080	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L21SP5_RS18125	COG0335	large ribosomal subunit rRNA binding
L21SP5_RS18170	COG3385	transposase activity
L21SP5_RS18205	COG1136	(ABC) transporter
L21SP5_RS18215	COG0577	efflux transmembrane transporter activity
L21SP5_RS18230	COG2356	endonuclease I
L21SP5_RS18255	COG2198	Histidine kinase
L21SP5_RS18255	COG0643	Histidine kinase
L21SP5_RS18260	COG0835	chemotaxis
L21SP5_RS18265	COG0840	transmembrane signaling receptor activity
L21SP5_RS18305	COG1480	7TM receptor with intracellular HD hydrolase
L21SP5_RS18310	COG1331	Highly conserved protein containing a thioredoxin domain
L21SP5_RS18320	COG1022	Amp-dependent synthetase and ligase
L21SP5_RS18335	COG2205	protein histidine kinase activity
L21SP5_RS18335	COG3292	Two component regulator propeller
L21SP5_RS18335	COG0745	RESPONSE REGULATOR receiver
L21SP5_RS18345	COG3385	transposase activity
L21SP5_RS18360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L21SP5_RS18410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L21SP5_RS18415	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
L21SP5_RS18430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L21SP5_RS18435	COG0439	Biotin carboxylase
L21SP5_RS18440	COG0511	ligase activity, forming carbon-carbon bonds
L21SP5_RS18460	COG4771	TonB-dependent receptor
L21SP5_RS18465	COG1321	iron dependent repressor
L21SP5_RS18500	COG3385	transposase activity
L21SP5_RS18505	COG2957	Belongs to the agmatine deiminase family
L21SP5_RS18535	COG1288	antiporter activity
L21SP5_RS18540	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L21SP5_RS18545	COG1254	Belongs to the acylphosphatase family
L21SP5_RS18550	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
L21SP5_RS18565	COG0778	Nitroreductase
L21SP5_RS18580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L21SP5_RS18645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L21SP5_RS18650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L21SP5_RS18655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L21SP5_RS18675	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L21SP5_RS18680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L21SP5_RS18685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L21SP5_RS18700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L21SP5_RS18715	COG2871	sodium ion transport
L21SP5_RS18720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L21SP5_RS18730	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L21SP5_RS18735	COG1805	sodium ion transport
L21SP5_RS18740	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L21SP5_RS18750	COG2066	Belongs to the glutaminase family
L21SP5_RS18765	COG2972	Histidine kinase
L21SP5_RS18770	COG3279	Response regulator of the LytR AlgR family
L21SP5_RS18800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
L21SP5_RS18805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
L21SP5_RS18820	COG3328	transposase activity
L21SP5_RS18960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L21SP5_RS18965	COG0840	transmembrane signaling receptor activity
L21SP5_RS19020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
L21SP5_RS19025	COG0237	dephospho-CoA kinase activity
L21SP5_RS19035	COG1862	Preprotein translocase
L21SP5_RS19045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L21SP5_RS19055	COG4935	Belongs to the peptidase S8 family
L21SP5_RS19055	COG2234	aminopeptidase activity
L21SP5_RS19060	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
L21SP5_RS19080	COG3052	prosthetic group binding
L21SP5_RS19090	COG4953	penicillin-binding protein 1C
L21SP5_RS19100	COG1595	DNA-templated transcription, initiation
L21SP5_RS19125	COG1115	amino acid carrier protein
L21SP5_RS19140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L21SP5_RS19150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L21SP5_RS19160	COG1228	amidohydrolase
L21SP5_RS19185	COG4657	Part of a membrane complex involved in electron transport
L21SP5_RS19190	COG4660	Part of a membrane complex involved in electron transport
L21SP5_RS19195	COG4659	FMN binding
L21SP5_RS19200	COG4658	electron transport chain
L21SP5_RS19205	COG4656	Part of a membrane complex involved in electron transport
L21SP5_RS19210	COG2878	Part of a membrane complex involved in electron transport
L21SP5_RS19210	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
L21SP5_RS19220	COG4251	negative regulation of phosphorylation
L21SP5_RS19225	COG0784	Response regulator, receiver
L21SP5_RS19230	COG2205	protein histidine kinase activity
L21SP5_RS19230	COG0784	Response regulator, receiver
L21SP5_RS19235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L21SP5_RS19280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L21SP5_RS19285	COG0511	ligase activity, forming carbon-carbon bonds
L21SP5_RS19285	COG5016	pyruvate
L21SP5_RS19295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L21SP5_RS19300	COG0346	lactoylglutathione lyase activity
L21SP5_RS19305	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP5_RS19310	COG4946	Tricorn protease homolog
L21SP5_RS19310	COG0793	Belongs to the peptidase S41A family
L21SP5_RS19320	COG1215	transferase activity, transferring glycosyl groups
L21SP5_RS19330	COG0735	belongs to the Fur family
L21SP5_RS19335	COG0450	alkyl hydroperoxide reductase
L21SP5_RS19345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L21SP5_RS19355	COG0653	protein targeting
L21SP5_RS19370	COG0385	Bile acid
L21SP5_RS19375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP5_RS19380	COG0552	protein localization to endoplasmic reticulum
L21SP5_RS19385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L21SP5_RS19390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L21SP5_RS19395	COG1546	Belongs to the CinA family
L21SP5_RS19395	COG1058	Belongs to the CinA family
L21SP5_RS19400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
L21SP5_RS19410	COG0860	N-Acetylmuramoyl-L-alanine amidase