locus-tag	class	description
RGRSB_RS00010	COG0033	Phosphoglucomutase
RGRSB_RS00015	COG0193	aminoacyl-tRNA hydrolase activity
RGRSB_RS00025	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RGRSB_RS00030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RGRSB_RS00040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RGRSB_RS00060	COG0799	negative regulation of ribosome biogenesis
RGRSB_RS00070	COG0542	response to heat
RGRSB_RS00075	COG0456	acetyltransferase
RGRSB_RS00075	COG1214	PFAM Peptidase M22, glycoprotease
RGRSB_RS00080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RGRSB_RS00085	COG4581	dead DEAH box helicase
RGRSB_RS00095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RGRSB_RS00105	COG1492	cobalamin metabolic process
RGRSB_RS00125	COG2099	Precorrin-6x reductase
RGRSB_RS00155	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
RGRSB_RS00160	COG0009	L-threonylcarbamoyladenylate synthase
RGRSB_RS00175	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RGRSB_RS00190	COG0783	Belongs to the Dps family
RGRSB_RS00200	COG1968	undecaprenyl-diphosphatase activity
RGRSB_RS00205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RGRSB_RS00210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RGRSB_RS00250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RGRSB_RS00265	COG1132	(ABC) transporter
RGRSB_RS00275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RGRSB_RS00275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RGRSB_RS00285	COG0742	ribosomal rna small subunit methyltransferase
RGRSB_RS00290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RGRSB_RS00295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGRSB_RS00305	COG0454	-acetyltransferase
RGRSB_RS00325	COG2890	protein-(glutamine-N5) methyltransferase activity
RGRSB_RS00330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RGRSB_RS00345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RGRSB_RS00350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RGRSB_RS00355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RGRSB_RS00360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RGRSB_RS00365	COG0793	Belongs to the peptidase S41A family
RGRSB_RS00375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RGRSB_RS00380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGRSB_RS00380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RGRSB_RS00390	COG0598	Magnesium transport protein CorA
RGRSB_RS00405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RGRSB_RS00420	COG0228	four-way junction DNA binding
RGRSB_RS00425	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGRSB_RS00435	COG1122	ATPase activity
RGRSB_RS00455	COG0392	lysyltransferase activity
RGRSB_RS00460	COG0071	Belongs to the small heat shock protein (HSP20) family
RGRSB_RS00465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RGRSB_RS00475	COG1473	amidohydrolase
RGRSB_RS00485	COG0653	protein targeting
RGRSB_RS00490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RGRSB_RS00495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RGRSB_RS00505	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RGRSB_RS00515	COG1799	cell septum assembly
RGRSB_RS00520	COG0659	secondary active sulfate transmembrane transporter activity
RGRSB_RS00525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGRSB_RS00550	COG0724	RNA recognition motif
RGRSB_RS00565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RGRSB_RS00570	COG1012	belongs to the aldehyde dehydrogenase family
RGRSB_RS00575	COG0473	3-isopropylmalate dehydrogenase activity
RGRSB_RS00585	COG0366	Alpha amylase catalytic
RGRSB_RS00590	COG0569	domain protein
RGRSB_RS00595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RGRSB_RS00600	COG2247	cell wall binding repeat
RGRSB_RS00600	COG2385	sporulation resulting in formation of a cellular spore
RGRSB_RS00630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RGRSB_RS00635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RGRSB_RS00640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGRSB_RS00645	COG0529	Catalyzes the synthesis of activated sulfate
RGRSB_RS00650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RGRSB_RS00680	COG1331	Highly conserved protein containing a thioredoxin domain
RGRSB_RS00690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RGRSB_RS00700	COG5322	oxidoreductase activity
RGRSB_RS00710	COG0728	peptidoglycan biosynthetic process
RGRSB_RS00730	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RGRSB_RS00740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RGRSB_RS00745	COG3932	Exopolysaccharide synthesis, ExoD
RGRSB_RS00755	COG3258	Cytochrome c
RGRSB_RS00760	COG0723	plastoquinol--plastocyanin reductase activity
RGRSB_RS00765	COG0154	amidase activity
RGRSB_RS00780	COG0009	L-threonylcarbamoyladenylate synthase
RGRSB_RS00795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RGRSB_RS00805	COG0180	Tryptophanyl-tRNA synthetase
RGRSB_RS00820	COG0058	SHG alpha-glucan phosphorylase activity
RGRSB_RS00825	COG0058	SHG alpha-glucan phosphorylase activity
RGRSB_RS00830	COG0058	SHG alpha-glucan phosphorylase activity
RGRSB_RS00855	COG3338	carbonate dehydratase activity
RGRSB_RS00880	COG0488	(ABC) transporter
RGRSB_RS00890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RGRSB_RS00900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RGRSB_RS00905	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RGRSB_RS00910	COG3118	belongs to the thioredoxin family
RGRSB_RS00915	COG0297	glycogen (starch) synthase activity
RGRSB_RS00920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGRSB_RS00925	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
RGRSB_RS00930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RGRSB_RS00935	COG0194	GDP metabolic process
RGRSB_RS00940	COG2052	Domain of unknown function (DUF370)
RGRSB_RS00945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RGRSB_RS00950	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RGRSB_RS00955	COG1472	Belongs to the glycosyl hydrolase 3 family
RGRSB_RS00960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RGRSB_RS00965	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RGRSB_RS00970	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RGRSB_RS00995	COG0215	cysteine-tRNA ligase activity
RGRSB_RS01000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RGRSB_RS01005	COG1126	abc transporter atp-binding protein
RGRSB_RS01015	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RGRSB_RS01020	COG0242	peptide deformylase activity
RGRSB_RS01025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RGRSB_RS01030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RGRSB_RS01040	COG0612	Peptidase, M16
RGRSB_RS01045	COG3937	granule-associated protein
RGRSB_RS01050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGRSB_RS01055	COG0631	protein serine/threonine phosphatase activity
RGRSB_RS01065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGRSB_RS01070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RGRSB_RS01075	COG0564	pseudouridine synthase activity
RGRSB_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
RGRSB_RS01085	COG0028	Belongs to the TPP enzyme family
RGRSB_RS01095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RGRSB_RS01100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RGRSB_RS01105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RGRSB_RS01115	COG2267	carboxylic ester hydrolase activity
RGRSB_RS01130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RGRSB_RS01145	COG0483	inositol monophosphate 1-phosphatase activity
RGRSB_RS01160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RGRSB_RS01165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RGRSB_RS01185	COG4555	ABC transporter
RGRSB_RS01190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGRSB_RS01195	COG0217	transcriptional regulatory protein
RGRSB_RS01205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RGRSB_RS01210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RGRSB_RS01230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RGRSB_RS01275	COG0601	transmembrane transport
RGRSB_RS01280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RGRSB_RS01300	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RGRSB_RS01310	COG1196	nuclear chromosome segregation
RGRSB_RS01315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RGRSB_RS01320	COG0857	belongs to the CobB CobQ family
RGRSB_RS01325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RGRSB_RS01335	COG2226	methyltransferase
RGRSB_RS01340	COG0768	penicillin binding
RGRSB_RS01355	COG2208	phosphoserine phosphatase activity
RGRSB_RS01365	COG0165	Argininosuccinate lyase
RGRSB_RS01405	COG0725	ABC transporter, periplasmic molybdate-binding protein
RGRSB_RS01410	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RGRSB_RS01420	COG1376	ErfK ybiS ycfS ynhG family protein
RGRSB_RS01425	COG3659	wide pore channel activity
RGRSB_RS01430	COG0154	amidase activity
RGRSB_RS01435	COG0312	modulator of DNA gyrase
RGRSB_RS01440	COG0552	protein localization to endoplasmic reticulum
RGRSB_RS01455	COG0701	Predicted permease
RGRSB_RS01465	COG2082	Precorrin-8x methylmutase
RGRSB_RS01470	COG4597	amino acid ABC transporter
RGRSB_RS01475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGRSB_RS01490	COG0275	rRNA processing
RGRSB_RS01495	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RGRSB_RS01500	COG4251	negative regulation of phosphorylation
RGRSB_RS01510	COG3437	response regulator, receiver
RGRSB_RS01510	COG4999	Histidine kinase
RGRSB_RS01510	COG2205	protein histidine kinase activity
RGRSB_RS01510	COG3850	Histidine kinase
RGRSB_RS01530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RGRSB_RS01535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RGRSB_RS01540	COG3239	Fatty acid desaturase
RGRSB_RS01555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RGRSB_RS01585	COG0628	permease
RGRSB_RS01600	COG0495	leucyl-tRNA aminoacylation
RGRSB_RS01605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RGRSB_RS01610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RGRSB_RS01640	COG0045	succinate-CoA ligase (ADP-forming) activity
RGRSB_RS01645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGRSB_RS01660	COG1994	Peptidase M50
RGRSB_RS01660	COG0517	IMP dehydrogenase activity
RGRSB_RS01665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RGRSB_RS01685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RGRSB_RS01695	COG0195	Participates in both transcription termination and antitermination
RGRSB_RS01700	COG0779	Required for maturation of 30S ribosomal subunits
RGRSB_RS01710	COG1672	PFAM Archaeal ATPase
RGRSB_RS01710	COG2319	Wd-40 repeat
RGRSB_RS01715	COG2046	Belongs to the sulfate adenylyltransferase family
RGRSB_RS01720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RGRSB_RS01725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RGRSB_RS01735	COG0163	prenyltransferase activity
RGRSB_RS01745	COG0395	ABC-type sugar transport system, permease component
RGRSB_RS01750	COG1175	transmembrane transport
RGRSB_RS01755	COG1653	transport
RGRSB_RS01760	COG3842	ATPase activity
RGRSB_RS01765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RGRSB_RS01770	COG0646	methionine synthase
RGRSB_RS01770	COG1410	methionine synthase
RGRSB_RS01780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RGRSB_RS01785	COG0268	Binds directly to 16S ribosomal RNA
RGRSB_RS01790	COG0084	hydrolase, TatD family'
RGRSB_RS01795	COG0085	RNA polymerase activity
RGRSB_RS01800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RGRSB_RS01820	COG0778	Nitroreductase
RGRSB_RS01825	COG0445	tRNA wobble uridine modification
RGRSB_RS01835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RGRSB_RS01855	COG0515	serine threonine protein kinase
RGRSB_RS01865	COG0372	Belongs to the citrate synthase family
RGRSB_RS01870	COG0481	GTPase activity
RGRSB_RS01880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RGRSB_RS01885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RGRSB_RS01895	COG0475	glutathione-regulated potassium exporter activity
RGRSB_RS01900	COG0860	N-Acetylmuramoyl-L-alanine amidase
RGRSB_RS01905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RGRSB_RS01910	COG0142	geranyltranstransferase activity
RGRSB_RS01915	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RGRSB_RS01945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RGRSB_RS01950	COG0083	homoserine kinase activity
RGRSB_RS01960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RGRSB_RS01965	COG5002	protein histidine kinase activity
RGRSB_RS01980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RGRSB_RS01980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RGRSB_RS02030	COG0509	glycine decarboxylation via glycine cleavage system
RGRSB_RS02050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RGRSB_RS02060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGRSB_RS02075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RGRSB_RS02085	COG0356	it plays a direct role in the translocation of protons across the membrane
RGRSB_RS02090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGRSB_RS02095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RGRSB_RS02100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RGRSB_RS02105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RGRSB_RS02110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RGRSB_RS02115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RGRSB_RS02120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RGRSB_RS02125	COG1381	Involved in DNA repair and RecF pathway recombination
RGRSB_RS02135	COG1429	ligase activity, forming nitrogen-metal bonds
RGRSB_RS02155	COG0138	bifunctional purine biosynthesis protein purh
RGRSB_RS02160	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RGRSB_RS02170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RGRSB_RS02175	COG0047	phosphoribosylformylglycinamidine synthase activity
RGRSB_RS02180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RGRSB_RS02200	COG0681	Belongs to the peptidase S26 family
RGRSB_RS02230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RGRSB_RS02235	COG0484	heat shock protein binding
RGRSB_RS02240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RGRSB_RS02245	COG0023	Translation Initiation Factor
RGRSB_RS02250	COG0402	S-adenosylhomocysteine deaminase activity
RGRSB_RS02255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RGRSB_RS02265	COG0515	serine threonine protein kinase
RGRSB_RS02270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RGRSB_RS02275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RGRSB_RS02280	COG0088	Forms part of the polypeptide exit tunnel
RGRSB_RS02285	COG0089	rRNA binding
RGRSB_RS02290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RGRSB_RS02295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RGRSB_RS02300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RGRSB_RS02305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RGRSB_RS02310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RGRSB_RS02315	COG0255	Belongs to the universal ribosomal protein uL29 family
RGRSB_RS02320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RGRSB_RS02325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RGRSB_RS02330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RGRSB_RS02335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RGRSB_RS02340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RGRSB_RS02345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RGRSB_RS02350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RGRSB_RS02355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RGRSB_RS02360	COG0200	Binds to the 23S rRNA
RGRSB_RS02365	COG0201	protein transport
RGRSB_RS02370	COG0563	adenylate kinase activity
RGRSB_RS02375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RGRSB_RS02380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RGRSB_RS02385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RGRSB_RS02390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RGRSB_RS02395	COG0202	RNA polymerase activity
RGRSB_RS02400	COG0203	ribosomal protein L17
RGRSB_RS02405	COG0101	tRNA pseudouridine synthase activity
RGRSB_RS02410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RGRSB_RS02415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RGRSB_RS02420	COG0254	rRNA binding
RGRSB_RS02425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RGRSB_RS02450	COG0587	DNA-directed DNA polymerase activity
RGRSB_RS02455	COG0175	sulfate reduction
RGRSB_RS02465	COG0528	UMP kinase activity
RGRSB_RS02470	COG0233	cytoplasmic translational termination
RGRSB_RS02495	COG1473	amidohydrolase
RGRSB_RS02505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RGRSB_RS02510	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RGRSB_RS02520	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RGRSB_RS02525	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGRSB_RS02530	COG2385	sporulation resulting in formation of a cellular spore
RGRSB_RS02535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RGRSB_RS02545	COG2166	iron-sulfur cluster assembly
RGRSB_RS02555	COG1104	cysteine desulfurase activity
RGRSB_RS02585	COG0573	inorganic phosphate transmembrane transporter activity
RGRSB_RS02590	COG0581	inorganic phosphate transmembrane transporter activity
RGRSB_RS02595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RGRSB_RS02600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RGRSB_RS02605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RGRSB_RS02625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RGRSB_RS02630	COG0745	RESPONSE REGULATOR receiver
RGRSB_RS02635	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
RGRSB_RS02640	COG1054	Belongs to the UPF0176 family
RGRSB_RS02670	COG0443	Heat shock 70 kDa protein
RGRSB_RS02680	COG0438	transferase activity, transferring glycosyl groups
RGRSB_RS02690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RGRSB_RS02695	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RGRSB_RS02700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RGRSB_RS02705	COG2239	Acts as a magnesium transporter
RGRSB_RS02710	COG0440	acetolactate synthase activity
RGRSB_RS02730	COG0179	Fumarylacetoacetate (FAA) hydrolase
RGRSB_RS02735	COG0360	Binds together with S18 to 16S ribosomal RNA
RGRSB_RS02740	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RGRSB_RS02745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGRSB_RS02755	COG1088	dTDP-glucose 4,6-dehydratase activity
RGRSB_RS02770	COG2091	lysine biosynthetic process via aminoadipic acid
RGRSB_RS02785	COG0540	Belongs to the ATCase OTCase family
RGRSB_RS02800	COG1252	NADH dehydrogenase
RGRSB_RS02815	COG0371	Dehydrogenase
RGRSB_RS02820	COG0589	response to stress
RGRSB_RS02825	COG0126	phosphoglycerate kinase activity
RGRSB_RS02830	COG3794	PFAM blue (type 1) copper domain protein
RGRSB_RS02835	COG0436	Aminotransferase
RGRSB_RS02840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RGRSB_RS02845	COG0575	Belongs to the CDS family
RGRSB_RS02855	COG0343	queuine tRNA-ribosyltransferase activity
RGRSB_RS02860	COG3659	wide pore channel activity
RGRSB_RS02865	COG0704	Plays a role in the regulation of phosphate uptake
RGRSB_RS02870	COG0024	Methionine aminopeptidase
RGRSB_RS02890	COG0681	Belongs to the peptidase S26 family
RGRSB_RS02900	COG0375	protein maturation
RGRSB_RS02905	COG0429	hydrolase of the alpha beta-hydrolase fold
RGRSB_RS02910	COG0745	RESPONSE REGULATOR receiver
RGRSB_RS02915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RGRSB_RS02920	COG1185	polyribonucleotide nucleotidyltransferase activity
RGRSB_RS02950	COG2205	protein histidine kinase activity
RGRSB_RS02955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RGRSB_RS02980	COG1333	cytochrome c biogenesis protein
RGRSB_RS02990	COG0525	valine-tRNA ligase activity
RGRSB_RS03000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RGRSB_RS03015	COG2010	Cytochrome c
RGRSB_RS03025	COG1215	transferase activity, transferring glycosyl groups
RGRSB_RS03030	COG0300	oxidoreductase activity
RGRSB_RS03030	COG3000	fatty acid hydroxylase
RGRSB_RS03035	COG1122	ATPase activity
RGRSB_RS03055	COG0811	peptide transport
RGRSB_RS03060	COG0848	biopolymer transport protein
RGRSB_RS03075	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RGRSB_RS03100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGRSB_RS03105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RGRSB_RS03105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RGRSB_RS03110	COG0556	nucleotide-excision repair
RGRSB_RS03115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RGRSB_RS03125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RGRSB_RS03150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RGRSB_RS03155	COG2124	cytochrome p450
RGRSB_RS03160	COG1615	UPF0182 protein
RGRSB_RS03195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RGRSB_RS03205	COG2192	nodulation
RGRSB_RS03215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGRSB_RS03225	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
RGRSB_RS03250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RGRSB_RS03255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RGRSB_RS03260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RGRSB_RS03265	COG0739	heme binding
RGRSB_RS03270	COG0401	homolog of Blt101
RGRSB_RS03275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RGRSB_RS03280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RGRSB_RS03285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RGRSB_RS03290	COG0544	peptidyl-prolyl cis-trans isomerase activity
RGRSB_RS03295	COG0740	serine-type endopeptidase activity
RGRSB_RS03300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RGRSB_RS03305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RGRSB_RS03340	COG0708	Exodeoxyribonuclease III
RGRSB_RS03345	COG0793	Belongs to the peptidase S41A family
RGRSB_RS03355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RGRSB_RS03355	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RGRSB_RS03360	COG1562	ergosterol biosynthetic process
RGRSB_RS03375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RGRSB_RS03395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RGRSB_RS03400	COG0006	proline dipeptidase activity
RGRSB_RS03420	COG0300	oxidoreductase activity
RGRSB_RS03425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RGRSB_RS03440	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RGRSB_RS03440	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RGRSB_RS03445	COG2363	Small membrane protein
RGRSB_RS03455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RGRSB_RS03460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RGRSB_RS03475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGRSB_RS03490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RGRSB_RS03495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGRSB_RS03510	COG1595	DNA-templated transcription, initiation
RGRSB_RS03520	COG1022	Amp-dependent synthetase and ligase
RGRSB_RS03525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RGRSB_RS03535	COG0328	RNA-DNA hybrid ribonuclease activity
RGRSB_RS03540	COG0004	ammonium transporteR
RGRSB_RS03545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RGRSB_RS03545	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RGRSB_RS03550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RGRSB_RS03555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RGRSB_RS03560	COG0557	exoribonuclease II activity
RGRSB_RS03580	COG0181	hydroxymethylbilane synthase activity
RGRSB_RS03585	COG0408	coproporphyrinogen oxidase activity
RGRSB_RS03590	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RGRSB_RS03600	COG0352	thiamine-phosphate diphosphorylase activity
RGRSB_RS03625	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RGRSB_RS03635	COG0436	Aminotransferase
RGRSB_RS03655	COG0601	transmembrane transport
RGRSB_RS03660	COG0135	phosphoribosylanthranilate isomerase activity
RGRSB_RS03680	COG0588	phosphoglycerate mutase activity
RGRSB_RS03685	COG0066	3-isopropylmalate dehydratase activity
RGRSB_RS03690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RGRSB_RS03695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGRSB_RS03705	COG0681	Belongs to the peptidase S26 family
RGRSB_RS03720	COG4399	Belongs to the UPF0754 family
RGRSB_RS03725	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RGRSB_RS03735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RGRSB_RS03745	COG2310	stress, protein
RGRSB_RS03755	COG0670	Belongs to the BI1 family
RGRSB_RS03775	COG1649	PFAM Uncharacterised BCR, COG1649
RGRSB_RS03780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RGRSB_RS03790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGRSB_RS03805	COG0484	heat shock protein binding
RGRSB_RS03815	COG1959	2 iron, 2 sulfur cluster binding
RGRSB_RS03820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RGRSB_RS03825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RGRSB_RS03830	COG0776	regulation of translation
RGRSB_RS03855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGRSB_RS03870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RGRSB_RS03890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RGRSB_RS03895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RGRSB_RS03915	COG1619	proteins homologs of microcin C7 resistance protein MccF
RGRSB_RS03920	COG0463	Glycosyl transferase, family 2
RGRSB_RS03925	COG0137	argininosuccinate synthase activity
RGRSB_RS03930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RGRSB_RS03950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RGRSB_RS03965	COG0805	protein transport
RGRSB_RS03975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RGRSB_RS03985	COG0587	DNA-directed DNA polymerase activity
RGRSB_RS04020	COG1160	GTP binding
RGRSB_RS04030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGRSB_RS04035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RGRSB_RS04050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RGRSB_RS04060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RGRSB_RS04075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RGRSB_RS04080	COG2205	protein histidine kinase activity
RGRSB_RS04085	COG0784	Response regulator, receiver
RGRSB_RS04085	COG2205	protein histidine kinase activity
RGRSB_RS04095	COG0116	Belongs to the methyltransferase superfamily
RGRSB_RS04100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGRSB_RS04105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RGRSB_RS04135	COG4536	flavin adenine dinucleotide binding
RGRSB_RS04160	COG1032	radical SAM domain protein
RGRSB_RS04165	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RGRSB_RS04170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RGRSB_RS04175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RGRSB_RS04180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RGRSB_RS04185	COG1316	TRANSCRIPTIONal
RGRSB_RS04195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RGRSB_RS04210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGRSB_RS04215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RGRSB_RS04220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RGRSB_RS04225	COG0017	Asparaginyl-tRNA synthetase
RGRSB_RS04245	COG0751	glycine-tRNA ligase activity
RGRSB_RS04280	COG0537	adenosine 5'-monophosphoramidase activity
RGRSB_RS04285	COG0316	Belongs to the HesB IscA family
RGRSB_RS04295	COG0501	Belongs to the peptidase M48B family
RGRSB_RS04320	COG0463	Glycosyl transferase, family 2
RGRSB_RS04335	COG2226	methyltransferase
RGRSB_RS04360	COG0438	transferase activity, transferring glycosyl groups
RGRSB_RS04385	COG0673	inositol 2-dehydrogenase activity
RGRSB_RS04410	COG2045	Belongs to the ComB family
RGRSB_RS04415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RGRSB_RS04440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RGRSB_RS04445	COG1136	(ABC) transporter
RGRSB_RS04445	COG0577	efflux transmembrane transporter activity
RGRSB_RS04450	COG2255	four-way junction helicase activity
RGRSB_RS04460	COG0752	glycyl-tRNA synthetase alpha subunit
RGRSB_RS04475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGRSB_RS04480	COG0709	Synthesizes selenophosphate from selenide and ATP
RGRSB_RS04490	COG0709	Synthesizes selenophosphate from selenide and ATP
RGRSB_RS04525	COG1605	Chorismate mutase
RGRSB_RS04525	COG0077	Prephenate dehydratase
RGRSB_RS04530	COG1530	ribonuclease E activity
RGRSB_RS04545	COG0237	dephospho-CoA kinase activity
RGRSB_RS04555	COG1104	cysteine desulfurase activity
RGRSB_RS04560	COG0793	Belongs to the peptidase S41A family
RGRSB_RS04575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RGRSB_RS04590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RGRSB_RS04610	COG0450	alkyl hydroperoxide reductase
RGRSB_RS04625	COG0484	heat shock protein binding
RGRSB_RS04655	COG0505	Belongs to the CarA family
RGRSB_RS04675	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
RGRSB_RS04685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RGRSB_RS04690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RGRSB_RS04695	COG0613	PHP domain protein
RGRSB_RS04720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RGRSB_RS04730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RGRSB_RS04740	COG0439	Biotin carboxylase
RGRSB_RS04745	COG0166	Belongs to the GPI family
RGRSB_RS04755	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RGRSB_RS04765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RGRSB_RS04775	COG0069	glutamate synthase activity
RGRSB_RS04775	COG0067	glutamate synthase
RGRSB_RS04775	COG0070	glutamate synthase
RGRSB_RS04790	COG0739	heme binding
RGRSB_RS04795	COG0460	homoserine dehydrogenase
RGRSB_RS04820	COG3854	ATPases associated with a variety of cellular activities
RGRSB_RS04830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RGRSB_RS04845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RGRSB_RS04855	COG0484	heat shock protein binding
RGRSB_RS04860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RGRSB_RS04870	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RGRSB_RS04875	COG1268	BioY protein
RGRSB_RS04880	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RGRSB_RS04885	COG2154	pterin-4-alpha-carbinolamine dehydratase
RGRSB_RS04905	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
RGRSB_RS04910	COG1702	phosphate starvation-inducible protein PhoH
RGRSB_RS04915	COG0649	NAD binding
RGRSB_RS04920	COG0037	tRNA processing
RGRSB_RS04930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RGRSB_RS04940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RGRSB_RS04945	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RGRSB_RS04950	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RGRSB_RS04965	COG0357	Ribosomal RNA small subunit methyltransferase G
RGRSB_RS04975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RGRSB_RS04980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RGRSB_RS04985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RGRSB_RS04990	COG0602	queuosine metabolic process
RGRSB_RS05005	COG0113	porphobilinogen synthase activity
RGRSB_RS05010	COG1187	pseudouridine synthase activity
RGRSB_RS05030	COG0579	oxidoreductase
RGRSB_RS05035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RGRSB_RS05035	COG1754	DNA topoisomerase type I activity
RGRSB_RS05040	COG1489	DNA binding
RGRSB_RS05045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RGRSB_RS05050	COG1799	cell septum assembly
RGRSB_RS05055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RGRSB_RS05090	COG0436	Aminotransferase
RGRSB_RS05095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RGRSB_RS05135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RGRSB_RS05145	COG0673	inositol 2-dehydrogenase activity
RGRSB_RS05150	COG0574	Belongs to the PEP-utilizing enzyme family
RGRSB_RS05150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RGRSB_RS05155	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RGRSB_RS05160	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RGRSB_RS05165	COG1950	PFAM Membrane protein of
RGRSB_RS05180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RGRSB_RS05200	COG0470	DNA polymerase III
RGRSB_RS05210	COG2217	Heavy metal translocating P-type atpase
RGRSB_RS05215	COG0592	DNA-directed DNA polymerase activity
RGRSB_RS05235	COG0366	Alpha amylase catalytic
RGRSB_RS05245	COG1316	TRANSCRIPTIONal
RGRSB_RS05255	COG0515	serine threonine protein kinase
RGRSB_RS05265	COG0321	lipoyl(octanoyl) transferase activity
RGRSB_RS05270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RGRSB_RS05280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RGRSB_RS05285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RGRSB_RS05290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RGRSB_RS05295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGRSB_RS05315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RGRSB_RS05340	COG1049	propionate catabolic process, 2-methylcitrate cycle
RGRSB_RS05370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RGRSB_RS05385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGRSB_RS05395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RGRSB_RS05400	COG0052	Belongs to the universal ribosomal protein uS2 family
RGRSB_RS05405	COG0024	Methionine aminopeptidase
RGRSB_RS05415	COG1175	transmembrane transport
RGRSB_RS05420	COG0571	ribonuclease III activity
RGRSB_RS05435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RGRSB_RS05445	COG0259	pyridoxamine-phosphate oxidase activity
RGRSB_RS05450	COG0730	response to heat
RGRSB_RS05455	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RGRSB_RS05485	COG0802	atpase or kinase
RGRSB_RS05490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RGRSB_RS05510	COG0765	amino acid transport
RGRSB_RS05520	COG0837	glucose binding
RGRSB_RS05525	COG2131	deaminase
RGRSB_RS05530	COG0756	dUTP diphosphatase activity
RGRSB_RS05540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RGRSB_RS05550	COG0542	response to heat
RGRSB_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
RGRSB_RS05560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RGRSB_RS05565	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RGRSB_RS05570	COG0419	ATPase involved in DNA repair
RGRSB_RS05580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RGRSB_RS05590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RGRSB_RS05595	COG0051	transcription antitermination factor activity, RNA binding
RGRSB_RS05600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RGRSB_RS05605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGRSB_RS05610	COG0049	tRNA binding
RGRSB_RS05615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RGRSB_RS05620	COG0316	Belongs to the HesB IscA family
RGRSB_RS05625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RGRSB_RS05640	COG0424	maF-like protein
RGRSB_RS05645	COG1045	serine acetyltransferase
RGRSB_RS05660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RGRSB_RS05665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RGRSB_RS05670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RGRSB_RS05680	COG0285	dihydrofolate synthase activity
RGRSB_RS05685	COG0747	negative chemotaxis
RGRSB_RS05695	COG4372	Transposase
RGRSB_RS05700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RGRSB_RS05705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RGRSB_RS05710	COG2211	Major facilitator Superfamily
RGRSB_RS05725	COG1122	ATPase activity
RGRSB_RS05745	COG0390	transport system, permease component
RGRSB_RS05760	COG0140	phosphoribosyl-ATP diphosphatase activity
RGRSB_RS05760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RGRSB_RS05765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RGRSB_RS05785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RGRSB_RS05800	COG0516	GMP reductase activity
RGRSB_RS05805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RGRSB_RS05810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RGRSB_RS05820	COG1748	Saccharopine dehydrogenase
RGRSB_RS05830	COG0745	RESPONSE REGULATOR receiver
RGRSB_RS05840	COG0539	negative regulation of cytoplasmic translation
RGRSB_RS05845	COG2197	response regulator
RGRSB_RS05860	COG0434	BtpA family
RGRSB_RS05865	COG4243	Vitamin k epoxide reductase
RGRSB_RS05890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RGRSB_RS05895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RGRSB_RS05900	COG0504	CTP synthase activity
RGRSB_RS05905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RGRSB_RS05910	COG0511	ligase activity, forming carbon-carbon bonds
RGRSB_RS05920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RGRSB_RS05930	COG0571	ribonuclease III activity
RGRSB_RS05935	COG0463	Glycosyl transferase, family 2
RGRSB_RS05955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RGRSB_RS05960	COG0191	fructose-bisphosphate aldolase activity
RGRSB_RS05975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RGRSB_RS05980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RGRSB_RS05985	COG0512	Glutamine amidotransferase of anthranilate synthase
RGRSB_RS05985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RGRSB_RS06000	COG0583	DNA-binding transcription factor activity
RGRSB_RS06055	COG0363	glucosamine-6-phosphate deaminase activity
RGRSB_RS06070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RGRSB_RS06080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGRSB_RS06090	COG3265	gluconokinase activity
RGRSB_RS06100	COG3409	Peptidoglycan-binding domain 1 protein
RGRSB_RS06100	COG3429	Glucose-6-phosphate dehydrogenase subunit
RGRSB_RS06105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RGRSB_RS06110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RGRSB_RS06115	COG0432	Pfam Uncharacterised protein family UPF0047
RGRSB_RS06120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RGRSB_RS06125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RGRSB_RS06130	COG0018	arginyl-trna synthetase
RGRSB_RS06145	COG1797	cobyrinic acid a,c-diamide synthase activity
RGRSB_RS06150	COG3659	wide pore channel activity
RGRSB_RS06160	COG0469	pyruvate kinase activity
RGRSB_RS06165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RGRSB_RS06180	COG0312	modulator of DNA gyrase
RGRSB_RS06185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RGRSB_RS06190	COG0298	carbon dioxide binding
RGRSB_RS06195	COG0109	protoheme IX farnesyltransferase activity
RGRSB_RS06200	COG1612	heme a metabolic process
RGRSB_RS06205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RGRSB_RS06215	COG0488	(ABC) transporter
RGRSB_RS06220	COG0330	HflC and HflK could
RGRSB_RS06225	COG1372	Participates in initiation and elongation during chromosome replication
RGRSB_RS06225	COG0187	DNA topoisomerase II activity
RGRSB_RS06230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RGRSB_RS06240	COG1193	negative regulation of DNA recombination
RGRSB_RS06245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RGRSB_RS06250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGRSB_RS06255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RGRSB_RS06260	COG0022	dehydrogenase e1 component
RGRSB_RS06260	COG0508	dehydrogenase complex catalyzes the overall conversion of
RGRSB_RS06270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RGRSB_RS06275	COG1181	Belongs to the D-alanine--D-alanine ligase family
RGRSB_RS06290	COG0719	Fe-S assembly protein
RGRSB_RS06295	COG0396	ATPase activity
RGRSB_RS06300	COG0719	Fe-S assembly protein
RGRSB_RS06305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RGRSB_RS06315	COG2715	membrane protein required for spore maturation
RGRSB_RS06320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RGRSB_RS06325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RGRSB_RS06340	COG0538	isocitrate dehydrogenase activity
RGRSB_RS06370	COG2211	Major facilitator Superfamily
RGRSB_RS06380	COG0850	regulation of cytokinetic process
RGRSB_RS06385	COG2894	cell division
RGRSB_RS06390	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RGRSB_RS06395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RGRSB_RS06415	COG1640	4-alpha-glucanotransferase
RGRSB_RS06420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RGRSB_RS06430	COG0302	gtp cyclohydrolase
RGRSB_RS06435	COG4221	oxidoreductase activity
RGRSB_RS06440	COG0825	malonyl-CoA metabolic process
RGRSB_RS06455	COG0612	Peptidase, M16
RGRSB_RS06465	COG0222	ribosome binding
RGRSB_RS06470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RGRSB_RS06475	COG0081	regulation of translation
RGRSB_RS06480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RGRSB_RS06485	COG0250	Participates in transcription elongation, termination and antitermination
RGRSB_RS06490	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RGRSB_RS06500	COG0335	large ribosomal subunit rRNA binding
RGRSB_RS06510	COG0659	secondary active sulfate transmembrane transporter activity
RGRSB_RS06515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RGRSB_RS06530	COG3001	Fructosamine kinase
RGRSB_RS06535	COG0612	Peptidase, M16
RGRSB_RS06540	COG0740	serine-type endopeptidase activity
RGRSB_RS06550	COG0557	exoribonuclease II activity
RGRSB_RS06580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RGRSB_RS06590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RGRSB_RS06595	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RGRSB_RS06600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RGRSB_RS06610	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RGRSB_RS06620	COG5002	protein histidine kinase activity
RGRSB_RS06625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGRSB_RS06630	COG0497	DNA recombination
RGRSB_RS06640	COG0095	Lipoate-protein ligase
RGRSB_RS06645	COG0735	belongs to the Fur family
RGRSB_RS06665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RGRSB_RS06670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RGRSB_RS06675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RGRSB_RS06680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RGRSB_RS06695	COG0617	tRNA 3'-terminal CCA addition
RGRSB_RS06695	COG0517	IMP dehydrogenase activity
RGRSB_RS06695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RGRSB_RS06710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RGRSB_RS06720	COG0174	glutamine synthetase
RGRSB_RS06735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RGRSB_RS06740	COG1940	carbohydrate kinase activity
RGRSB_RS06750	COG0617	tRNA 3'-terminal CCA addition
RGRSB_RS06760	COG0515	serine threonine protein kinase
RGRSB_RS06770	COG1032	radical SAM domain protein
RGRSB_RS06775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RGRSB_RS06790	COG0336	Belongs to the RNA methyltransferase TrmD family
RGRSB_RS06795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RGRSB_RS06795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RGRSB_RS06800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RGRSB_RS06810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RGRSB_RS06830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RGRSB_RS06835	COG0513	Belongs to the DEAD box helicase family
RGRSB_RS06840	COG2197	response regulator
RGRSB_RS06845	COG2205	protein histidine kinase activity
RGRSB_RS06855	COG0196	riboflavin kinase activity
RGRSB_RS06875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RGRSB_RS06900	COG0571	ribonuclease III activity
RGRSB_RS06905	COG2188	Transcriptional regulator
RGRSB_RS06945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RGRSB_RS06950	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGRSB_RS06955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RGRSB_RS06965	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RGRSB_RS06980	COG0768	penicillin binding
RGRSB_RS06990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RGRSB_RS06995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RGRSB_RS07000	COG1845	cytochrome c oxidase, subunit III
RGRSB_RS07005	COG0003	Pfam Anion-transporting ATPase
RGRSB_RS07020	COG0129	dihydroxy-acid dehydratase activity
RGRSB_RS07025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RGRSB_RS07030	COG1090	epimerase
RGRSB_RS07040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RGRSB_RS07045	COG0459	protein refolding
RGRSB_RS07050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RGRSB_RS07060	COG0105	UTP biosynthetic process
RGRSB_RS07065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RGRSB_RS07070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RGRSB_RS07075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RGRSB_RS07080	COG3273	potassium ion transport
RGRSB_RS07080	COG0471	metal ion transport
RGRSB_RS07090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RGRSB_RS07110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RGRSB_RS07125	COG1691	(AIR) carboxylase
RGRSB_RS07130	COG0632	four-way junction helicase activity
RGRSB_RS07145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RGRSB_RS07160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RGRSB_RS07160	COG3264	Mechanosensitive ion channel
RGRSB_RS07180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RGRSB_RS07185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RGRSB_RS07200	COG0678	peroxiredoxin activity
RGRSB_RS07210	COG1132	(ABC) transporter
RGRSB_RS07220	COG2217	Heavy metal translocating P-type atpase
RGRSB_RS07250	COG1131	(ABC) transporter
RGRSB_RS07260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RGRSB_RS07275	COG0861	Integral membrane protein TerC family
RGRSB_RS07280	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RGRSB_RS07290	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RGRSB_RS07305	COG0572	uridine kinase
RGRSB_RS07325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RGRSB_RS07330	COG1160	GTP binding
RGRSB_RS07345	COG1192	Involved in chromosome partitioning
RGRSB_RS07355	COG2205	protein histidine kinase activity
RGRSB_RS07360	COG1543	Belongs to the glycosyl hydrolase 57 family
RGRSB_RS07370	COG0457	Tetratricopeptide repeat
RGRSB_RS07370	COG0463	Glycosyl transferase, family 2
RGRSB_RS07390	COG0346	lactoylglutathione lyase activity
RGRSB_RS07395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RGRSB_RS07410	COG0514	ATP-dependent DNA helicase (RecQ)
RGRSB_RS07420	COG0463	Glycosyl transferase, family 2
RGRSB_RS07425	COG0542	response to heat
RGRSB_RS07435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RGRSB_RS07435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RGRSB_RS07445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RGRSB_RS07460	COG0149	triose-phosphate isomerase activity
RGRSB_RS07465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RGRSB_RS07470	COG1166	arginine decarboxylase activity
RGRSB_RS07480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RGRSB_RS07510	COG0358	DNA primase activity
RGRSB_RS07520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RGRSB_RS07530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RGRSB_RS07540	COG3118	belongs to the thioredoxin family
RGRSB_RS07550	COG0824	Thioesterase
RGRSB_RS07565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RGRSB_RS07585	COG0124	histidyl-tRNA synthetase
RGRSB_RS07595	COG0590	tRNA wobble adenosine to inosine editing
RGRSB_RS07605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RGRSB_RS07610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RGRSB_RS07615	COG0019	diaminopimelate decarboxylase activity
RGRSB_RS07620	COG0720	synthase
RGRSB_RS07625	COG4783	chaperone-mediated protein folding
RGRSB_RS07635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RGRSB_RS07635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RGRSB_RS07640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RGRSB_RS07645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RGRSB_RS07650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RGRSB_RS07650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RGRSB_RS07655	COG0583	DNA-binding transcription factor activity
RGRSB_RS07665	COG0463	Glycosyl transferase, family 2
RGRSB_RS07700	COG5554	nitrogen fixation
RGRSB_RS07705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGRSB_RS07720	COG1045	serine acetyltransferase
RGRSB_RS07740	COG0822	iron-sulfur transferase activity
RGRSB_RS07740	COG2906	2 iron, 2 sulfur cluster binding
RGRSB_RS07740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RGRSB_RS07745	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RGRSB_RS07750	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGRSB_RS07755	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGRSB_RS07760	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGRSB_RS07765	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RGRSB_RS07780	COG5420	small protein containing a coiled-coil domain
RGRSB_RS07790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RGRSB_RS07795	COG0316	Belongs to the HesB IscA family
RGRSB_RS07800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RGRSB_RS07820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RGRSB_RS07835	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RGRSB_RS07840	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
RGRSB_RS07865	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGRSB_RS07870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGRSB_RS07875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGRSB_RS07890	COG0501	Belongs to the peptidase M48B family
RGRSB_RS07900	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RGRSB_RS07905	COG0745	RESPONSE REGULATOR receiver
RGRSB_RS07925	COG0284	orotidine-5'-phosphate decarboxylase activity
RGRSB_RS07935	COG0628	permease
RGRSB_RS07940	COG1074	ATP-dependent DNA helicase activity
RGRSB_RS07955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RGRSB_RS07960	COG2954	triphosphatase activity
RGRSB_RS07965	COG1217	gtp-binding protein TYPA
RGRSB_RS07975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RGRSB_RS07985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RGRSB_RS07995	COG2022	thiamine diphosphate biosynthetic process
RGRSB_RS07995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGRSB_RS08000	COG1836	PFAM Integral membrane protein DUF92
RGRSB_RS08005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RGRSB_RS08030	COG0713	ATP synthesis coupled electron transport
RGRSB_RS08035	COG0839	Belongs to the complex I subunit 6 family
RGRSB_RS08040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RGRSB_RS08045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RGRSB_RS08060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RGRSB_RS08065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RGRSB_RS08080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RGRSB_RS08090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RGRSB_RS08095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RGRSB_RS08100	COG0519	Catalyzes the synthesis of GMP from XMP
RGRSB_RS08100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RGRSB_RS08110	COG0131	Imidazoleglycerol-phosphate dehydratase
RGRSB_RS08125	COG0723	plastoquinol--plastocyanin reductase activity
RGRSB_RS08145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RGRSB_RS08145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RGRSB_RS08170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RGRSB_RS08175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGRSB_RS08175	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RGRSB_RS08180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RGRSB_RS08185	COG1546	Belongs to the CinA family
RGRSB_RS08185	COG1058	Belongs to the CinA family
RGRSB_RS08190	COG0701	Predicted permease
RGRSB_RS08205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RGRSB_RS08210	COG1597	lipid kinase activity
RGRSB_RS08215	COG1606	tRNA processing
RGRSB_RS08220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RGRSB_RS08245	COG0189	ligase activity
RGRSB_RS08250	COG0072	phenylalanine-tRNA ligase activity
RGRSB_RS08250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGRSB_RS08255	COG1088	dTDP-glucose 4,6-dehydratase activity
RGRSB_RS08275	COG0003	Pfam Anion-transporting ATPase
RGRSB_RS08280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RGRSB_RS08285	COG1496	oxidoreductase activity
RGRSB_RS08300	COG4251	negative regulation of phosphorylation
RGRSB_RS08305	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RGRSB_RS08315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RGRSB_RS08320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RGRSB_RS08335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RGRSB_RS08355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RGRSB_RS08365	COG0539	negative regulation of cytoplasmic translation
RGRSB_RS08380	COG0741	lytic transglycosylase activity
RGRSB_RS08405	COG0750	zinc metalloprotease
RGRSB_RS08410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RGRSB_RS08415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RGRSB_RS08420	COG0594	ribonuclease P activity
RGRSB_RS08430	COG0706	membrane insertase activity
RGRSB_RS08445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RGRSB_RS08450	COG0784	Response regulator, receiver
RGRSB_RS08450	COG2205	protein histidine kinase activity
RGRSB_RS08465	COG0271	Belongs to the BolA IbaG family
RGRSB_RS08470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RGRSB_RS08480	COG0745	RESPONSE REGULATOR receiver
RGRSB_RS08490	COG0170	dolichyl monophosphate biosynthetic process
RGRSB_RS08495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RGRSB_RS08500	COG0740	serine-type endopeptidase activity
RGRSB_RS08505	COG0740	serine-type endopeptidase activity
RGRSB_RS08520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RGRSB_RS08525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RGRSB_RS08535	COG0012	GTP binding
RGRSB_RS08540	COG0384	phenazine biosynthesis protein PhzF
RGRSB_RS08560	COG3536	Protein conserved in bacteria
RGRSB_RS08565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RGRSB_RS08570	COG0484	heat shock protein binding
RGRSB_RS08575	COG0443	Heat shock 70 kDa protein
RGRSB_RS08585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RGRSB_RS08590	COG0776	regulation of translation
RGRSB_RS08600	COG1480	7TM receptor with intracellular HD hydrolase
RGRSB_RS08605	COG0484	heat shock protein binding
RGRSB_RS08615	COG1162	GTPase activity
RGRSB_RS08620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RGRSB_RS08625	COG2264	protein methyltransferase activity
RGRSB_RS08635	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RGRSB_RS08645	COG0416	fatty acid biosynthetic process
RGRSB_RS08650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RGRSB_RS08655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RGRSB_RS08660	COG0800	Aldolase
RGRSB_RS08675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RGRSB_RS08685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RGRSB_RS08700	COG0482	sulfurtransferase activity
RGRSB_RS08705	COG1007	ATP synthesis coupled electron transport
RGRSB_RS08710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RGRSB_RS08715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RGRSB_RS08720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RGRSB_RS08725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RGRSB_RS08730	COG0483	inositol monophosphate 1-phosphatase activity
RGRSB_RS08735	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RGRSB_RS08740	COG0107	imidazoleglycerol-phosphate synthase activity
RGRSB_RS08760	COG0745	RESPONSE REGULATOR receiver
RGRSB_RS08775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RGRSB_RS08780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RGRSB_RS08785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RGRSB_RS08810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RGRSB_RS08820	COG0438	transferase activity, transferring glycosyl groups
RGRSB_RS08825	COG0629	single-stranded DNA binding
RGRSB_RS08830	COG1077	Cell shape determining protein MreB Mrl
RGRSB_RS08845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RGRSB_RS08855	COG0387	Pfam Sodium calcium exchanger
RGRSB_RS08870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RGRSB_RS08875	COG0668	transmembrane transport
RGRSB_RS08900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGRSB_RS08910	COG1116	anion transmembrane transporter activity
RGRSB_RS08910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RGRSB_RS08920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RGRSB_RS08925	COG0803	Belongs to the bacterial solute-binding protein 9 family
RGRSB_RS08930	COG1121	(ABC) transporter
RGRSB_RS08935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RGRSB_RS08950	COG0523	cobalamin synthesis protein
RGRSB_RS08955	COG1982	Orn Lys Arg decarboxylase major
RGRSB_RS08960	COG0616	signal peptide processing
RGRSB_RS08980	COG0772	Belongs to the SEDS family
RGRSB_RS08985	COG0489	protein tyrosine kinase activity
RGRSB_RS09010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RGRSB_RS09015	COG0148	phosphopyruvate hydratase activity
RGRSB_RS09020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RGRSB_RS09035	COG0114	fumarate hydratase activity
RGRSB_RS09040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RGRSB_RS09085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RGRSB_RS09090	COG0151	Belongs to the GarS family
RGRSB_RS09095	COG3339	Conserved Protein
RGRSB_RS09105	COG1845	cytochrome c oxidase, subunit III
RGRSB_RS09115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RGRSB_RS09130	COG1252	NADH dehydrogenase
RGRSB_RS09160	COG0415	Belongs to the DNA photolyase family
RGRSB_RS09165	COG0494	nUDIX hydrolase
RGRSB_RS09170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RGRSB_RS09175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RGRSB_RS09180	COG0662	Cupin 2, conserved barrel domain protein
RGRSB_RS09180	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RGRSB_RS09185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RGRSB_RS09190	COG0398	Pfam SNARE associated Golgi protein
RGRSB_RS09200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RGRSB_RS09210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RGRSB_RS09215	COG1657	PFAM Prenyltransferase squalene oxidase
RGRSB_RS09220	COG1981	membrane
RGRSB_RS09225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RGRSB_RS09225	COG2022	thiamine diphosphate biosynthetic process
RGRSB_RS09235	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
RGRSB_RS09245	COG0322	excinuclease ABC activity
RGRSB_RS09250	COG0395	ABC-type sugar transport system, permease component
RGRSB_RS09265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RGRSB_RS09270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RGRSB_RS09295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RGRSB_RS09310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RGRSB_RS09315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RGRSB_RS09320	COG0189	ligase activity
RGRSB_RS09360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RGRSB_RS09365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RGRSB_RS09370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RGRSB_RS09385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RGRSB_RS09395	COG0586	Pfam SNARE associated Golgi protein
RGRSB_RS09405	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RGRSB_RS09410	COG1372	Participates in initiation and elongation during chromosome replication
RGRSB_RS09410	COG0305	Participates in initiation and elongation during chromosome replication
RGRSB_RS09420	COG0577	efflux transmembrane transporter activity
RGRSB_RS09420	COG1136	(ABC) transporter
RGRSB_RS09430	COG0459	protein refolding
RGRSB_RS09435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RGRSB_RS09450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RGRSB_RS09460	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RGRSB_RS09465	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RGRSB_RS09490	COG0159	tryptophan synthase activity
RGRSB_RS09500	COG1132	(ABC) transporter
RGRSB_RS09510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RGRSB_RS09515	COG1357	PFAM Pentapeptide repeats (8 copies)
RGRSB_RS09525	COG0772	Belongs to the SEDS family
RGRSB_RS09530	COG1234	tRNA 3'-trailer cleavage
RGRSB_RS09545	COG0134	indole-3-glycerol-phosphate synthase activity
RGRSB_RS09565	COG0167	dihydroorotate dehydrogenase activity
RGRSB_RS09570	COG0359	binds to the 23S rRNA
RGRSB_RS09580	COG0730	response to heat
RGRSB_RS09600	COG0442	prolyl-tRNA aminoacylation
RGRSB_RS09605	COG0133	tryptophan synthase activity
RGRSB_RS09615	COG0157	Belongs to the NadC ModD family
RGRSB_RS09630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RGRSB_RS09645	COG2081	HI0933 family
RGRSB_RS09655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RGRSB_RS09670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RGRSB_RS09675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RGRSB_RS09680	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RGRSB_RS09685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RGRSB_RS09690	COG0739	heme binding
RGRSB_RS09705	COG2197	response regulator
RGRSB_RS09710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RGRSB_RS09735	COG3118	belongs to the thioredoxin family
RGRSB_RS09740	COG1842	Phage shock protein A
RGRSB_RS09745	COG1842	Phage shock protein A
RGRSB_RS09750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RGRSB_RS09750	COG0512	Glutamine amidotransferase of anthranilate synthase
RGRSB_RS09770	COG1253	flavin adenine dinucleotide binding
RGRSB_RS09780	COG0058	SHG alpha-glucan phosphorylase activity
RGRSB_RS09785	COG1420	regulation of RNA biosynthetic process
RGRSB_RS09790	COG1054	Belongs to the UPF0176 family
RGRSB_RS09805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RGRSB_RS09810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RGRSB_RS09820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate