locus-tag	class	description
AZF37_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AZF37_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AZF37_RS00020	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AZF37_RS00020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AZF37_RS00025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AZF37_RS00035	COG0745	RESPONSE REGULATOR receiver
AZF37_RS00040	COG5002	protein histidine kinase activity
AZF37_RS00100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AZF37_RS00105	COG2890	protein-(glutamine-N5) methyltransferase activity
AZF37_RS00110	COG0009	L-threonylcarbamoyladenylate synthase
AZF37_RS00125	COG0698	ribose 5-phosphate isomerase
AZF37_RS00130	COG2131	deaminase
AZF37_RS00135	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AZF37_RS00145	COG0165	Argininosuccinate lyase
AZF37_RS00150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AZF37_RS00155	COG1316	TRANSCRIPTIONal
AZF37_RS00165	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AZF37_RS00180	COG0504	CTP synthase activity
AZF37_RS00185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AZF37_RS00200	COG2226	methyltransferase
AZF37_RS00235	COG1129	ABC transporter
AZF37_RS00240	COG1122	ATPase activity
AZF37_RS00285	COG1131	(ABC) transporter
AZF37_RS00290	COG1131	(ABC) transporter
AZF37_RS00295	COG2197	response regulator
AZF37_RS00315	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AZF37_RS00320	COG0328	RNA-DNA hybrid ribonuclease activity
AZF37_RS00340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZF37_RS00345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AZF37_RS00350	COG1253	flavin adenine dinucleotide binding
AZF37_RS00355	COG0534	Mate efflux family protein
AZF37_RS00365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AZF37_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
AZF37_RS00410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AZF37_RS00410	COG2010	Cytochrome c
AZF37_RS00425	COG4603	Belongs to the binding-protein-dependent transport system permease family
AZF37_RS00430	COG1079	Belongs to the binding-protein-dependent transport system permease family
AZF37_RS00435	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS00440	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS00450	COG3845	ABC transporter
AZF37_RS00455	COG1744	ABC transporter substrate-binding protein PnrA-like
AZF37_RS00490	COG2801	Transposase and inactivated derivatives
AZF37_RS00560	COG1309	transcriptional regulator
AZF37_RS00620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AZF37_RS00655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AZF37_RS00685	COG1129	ABC transporter
AZF37_RS00690	COG1129	ABC transporter
AZF37_RS00695	COG1129	ABC transporter
AZF37_RS00715	COG3594	Acyltransferase
AZF37_RS00735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZF37_RS00760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AZF37_RS00770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AZF37_RS00775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AZF37_RS00780	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AZF37_RS00785	COG1605	Chorismate mutase
AZF37_RS00785	COG0077	Prephenate dehydratase
AZF37_RS00795	COG0583	DNA-binding transcription factor activity
AZF37_RS00815	COG0709	Synthesizes selenophosphate from selenide and ATP
AZF37_RS00870	COG4221	oxidoreductase activity
AZF37_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
AZF37_RS00910	COG0793	Belongs to the peptidase S41A family
AZF37_RS00915	COG0556	nucleotide-excision repair
AZF37_RS00930	COG1595	DNA-templated transcription, initiation
AZF37_RS01085	COG1216	Glycosyl transferase, family 2
AZF37_RS01090	COG0562	UDP-galactopyranose mutase
AZF37_RS01100	COG1682	transport, permease protein
AZF37_RS01155	COG0398	Pfam SNARE associated Golgi protein
AZF37_RS01185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AZF37_RS01190	COG0726	polysaccharide deacetylase
AZF37_RS01210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AZF37_RS01215	COG0436	Aminotransferase
AZF37_RS01225	COG1733	regulation of RNA biosynthetic process
AZF37_RS01240	COG0789	Transcriptional regulator
AZF37_RS01300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZF37_RS01310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZF37_RS01330	COG1217	gtp-binding protein TYPA
AZF37_RS01335	COG3757	hydrolase, family 25
AZF37_RS01350	COG0513	Belongs to the DEAD box helicase family
AZF37_RS01490	COG1846	Transcriptional regulator
AZF37_RS01530	COG4106	trans-aconitate 2-methyltransferase activity
AZF37_RS01570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AZF37_RS01580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AZF37_RS01585	COG0632	four-way junction helicase activity
AZF37_RS01590	COG2255	four-way junction helicase activity
AZF37_RS01630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AZF37_RS01650	COG0028	Belongs to the TPP enzyme family
AZF37_RS01655	COG0028	Belongs to the TPP enzyme family
AZF37_RS01715	COG3757	hydrolase, family 25
AZF37_RS01735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AZF37_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AZF37_RS01760	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AZF37_RS01790	COG1194	a g-specific adenine glycosylase
AZF37_RS01810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZF37_RS01815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZF37_RS01820	COG4990	cell redox homeostasis
AZF37_RS01825	COG4990	cell redox homeostasis
AZF37_RS01855	COG0542	response to heat
AZF37_RS01860	COG0542	response to heat
AZF37_RS01865	COG0542	response to heat
AZF37_RS01870	COG0542	response to heat
AZF37_RS01885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZF37_RS01890	COG1058	Belongs to the CinA family
AZF37_RS01890	COG1546	Belongs to the CinA family
AZF37_RS01895	COG1546	Belongs to the CinA family
AZF37_RS01895	COG1058	Belongs to the CinA family
AZF37_RS01900	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS01905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF37_RS01910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF37_RS01915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF37_RS01920	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF37_RS01925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF37_RS01930	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AZF37_RS01935	COG0482	sulfurtransferase activity
AZF37_RS01955	COG2246	polysaccharide biosynthetic process
AZF37_RS01960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AZF37_RS01965	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AZF37_RS01965	COG3608	succinylglutamate desuccinylase aspartoacylase
AZF37_RS01970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AZF37_RS01970	COG3608	succinylglutamate desuccinylase aspartoacylase
AZF37_RS01980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AZF37_RS01990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AZF37_RS02000	COG0303	'Molybdopterin
AZF37_RS02010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AZF37_RS02015	COG0315	cyclic pyranopterin monophosphate synthase activity
AZF37_RS02025	COG0521	Mo-molybdopterin cofactor biosynthetic process
AZF37_RS02030	COG1191	sigma factor activity
AZF37_RS02045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AZF37_RS02050	COG0459	protein refolding
AZF37_RS02060	COG0037	tRNA processing
AZF37_RS02060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AZF37_RS02065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AZF37_RS02065	COG0519	Catalyzes the synthesis of GMP from XMP
AZF37_RS02075	COG1733	regulation of RNA biosynthetic process
AZF37_RS02090	COG1132	(ABC) transporter
AZF37_RS02105	COG4716	Myosin-crossreactive antigen
AZF37_RS02125	COG1129	ABC transporter
AZF37_RS02140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AZF37_RS02200	COG2205	protein histidine kinase activity
AZF37_RS02225	COG1174	glycine betaine transport
AZF37_RS02265	COG0133	tryptophan synthase activity
AZF37_RS02270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AZF37_RS02300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AZF37_RS02305	COG0582	viral genome integration into host DNA
AZF37_RS02315	COG0052	Belongs to the universal ribosomal protein uS2 family
AZF37_RS02320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AZF37_RS02330	COG0528	UMP kinase activity
AZF37_RS02340	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AZF37_RS02345	COG0575	Belongs to the CDS family
AZF37_RS02350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AZF37_RS02355	COG0750	zinc metalloprotease
AZF37_RS02360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AZF37_RS02365	COG0442	prolyl-tRNA aminoacylation
AZF37_RS02375	COG0617	tRNA 3'-terminal CCA addition
AZF37_RS02375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AZF37_RS02375	COG0517	IMP dehydrogenase activity
AZF37_RS02380	COG0281	malic enzyme
AZF37_RS02390	COG1739	Uncharacterized protein family UPF0029
AZF37_RS02405	COG2001	Belongs to the MraZ family
AZF37_RS02420	COG0768	penicillin binding
AZF37_RS02430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AZF37_RS02435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZF37_RS02440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AZF37_RS02445	COG0772	Belongs to the SEDS family
AZF37_RS02450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZF37_RS02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZF37_RS02460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AZF37_RS02465	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AZF37_RS02470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AZF37_RS02490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AZF37_RS02495	COG1799	cell septum assembly
AZF37_RS02500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AZF37_RS02505	COG2302	S4 RNA-binding domain
AZF37_RS02510	COG3599	regulation of cell shape
AZF37_RS02515	COG4869	propanediol catabolic process
AZF37_RS02520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AZF37_RS02525	COG0564	pseudouridine synthase activity
AZF37_RS02530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AZF37_RS02570	COG0860	N-Acetylmuramoyl-L-alanine amidase
AZF37_RS02575	COG3118	belongs to the thioredoxin family
AZF37_RS02580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AZF37_RS02585	COG0540	Belongs to the ATCase OTCase family
AZF37_RS02590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AZF37_RS02595	COG0543	2 iron, 2 sulfur cluster binding
AZF37_RS02600	COG0167	dihydroorotate dehydrogenase activity
AZF37_RS02605	COG0284	orotidine-5'-phosphate decarboxylase activity
AZF37_RS02610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AZF37_RS02630	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AZF37_RS02640	COG0356	it plays a direct role in the translocation of protons across the membrane
AZF37_RS02650	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZF37_RS02655	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZF37_RS02660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AZF37_RS02670	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AZF37_RS02675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AZF37_RS02690	COG0613	PHP domain protein
AZF37_RS02695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AZF37_RS02695	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AZF37_RS02700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AZF37_RS02705	COG0726	polysaccharide deacetylase
AZF37_RS02715	COG1773	rubredoxin
AZF37_RS02715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZF37_RS02795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AZF37_RS02805	COG2827	Endonuclease containing a URI domain
AZF37_RS02835	COG2188	Transcriptional regulator
AZF37_RS02845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZF37_RS02875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AZF37_RS02875	COG1328	CTP reductase activity
AZF37_RS02880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AZF37_RS02935	COG1307	EDD domain protein, DegV family
AZF37_RS02940	COG1307	EDD domain protein, DegV family
AZF37_RS02955	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AZF37_RS02960	COG0617	tRNA 3'-terminal CCA addition
AZF37_RS02970	COG0534	Mate efflux family protein
AZF37_RS02995	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AZF37_RS02995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AZF37_RS03050	COG4932	domain protein
AZF37_RS03050	COG4886	Leucine-rich repeat (LRR) protein
AZF37_RS03055	COG2314	TM2 domain
AZF37_RS03110	COG1121	(ABC) transporter
AZF37_RS03125	COG0288	reversible hydration of carbon dioxide
AZF37_RS03130	COG0628	permease
AZF37_RS03200	COG2233	PERMEase
AZF37_RS03205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZF37_RS03210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AZF37_RS03215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZF37_RS03215	COG0493	'glutamate synthase
AZF37_RS03220	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS03235	COG2080	2 iron, 2 sulfur cluster binding
AZF37_RS03255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZF37_RS03270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AZF37_RS03275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AZF37_RS03280	COG0250	Participates in transcription elongation, termination and antitermination
AZF37_RS03300	COG0222	ribosome binding
AZF37_RS03310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZF37_RS03315	COG1358	cellular component organization or biogenesis
AZF37_RS03320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AZF37_RS03325	COG0049	tRNA binding
AZF37_RS03330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZF37_RS03335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZF37_RS03340	COG0051	transcription antitermination factor activity, RNA binding
AZF37_RS03345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AZF37_RS03350	COG0088	Forms part of the polypeptide exit tunnel
AZF37_RS03355	COG0089	rRNA binding
AZF37_RS03360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AZF37_RS03365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AZF37_RS03370	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AZF37_RS03375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AZF37_RS03380	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AZF37_RS03385	COG0255	Belongs to the universal ribosomal protein uL29 family
AZF37_RS03390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AZF37_RS03395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AZF37_RS03400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AZF37_RS03410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AZF37_RS03415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AZF37_RS03420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AZF37_RS03425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AZF37_RS03430	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AZF37_RS03435	COG1841	ribosomal large subunit assembly
AZF37_RS03440	COG0200	Binds to the 23S rRNA
AZF37_RS03445	COG0201	protein transport
AZF37_RS03455	COG0024	Methionine aminopeptidase
AZF37_RS03460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AZF37_RS03465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AZF37_RS03470	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AZF37_RS03475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AZF37_RS03480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AZF37_RS03490	COG0203	ribosomal protein L17
AZF37_RS03520	COG1116	anion transmembrane transporter activity
AZF37_RS03535	COG0371	Dehydrogenase
AZF37_RS03540	COG0371	Dehydrogenase
AZF37_RS03630	COG2801	Transposase and inactivated derivatives
AZF37_RS03635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AZF37_RS03675	COG0569	domain protein
AZF37_RS03710	COG1876	peptidase activity
AZF37_RS03735	COG4657	Part of a membrane complex involved in electron transport
AZF37_RS03740	COG4660	Part of a membrane complex involved in electron transport
AZF37_RS03745	COG4659	FMN binding
AZF37_RS03750	COG4658	electron transport chain
AZF37_RS03755	COG4656	Part of a membrane complex involved in electron transport
AZF37_RS03760	COG0012	GTP binding
AZF37_RS03775	COG0758	DNA mediated transformation
AZF37_RS03780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AZF37_RS03790	COG0779	Required for maturation of 30S ribosomal subunits
AZF37_RS03795	COG0195	Participates in both transcription termination and antitermination
AZF37_RS03800	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AZF37_RS03810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AZF37_RS03810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AZF37_RS03815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AZF37_RS03820	COG1227	inorganic diphosphatase activity
AZF37_RS03825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AZF37_RS03830	COG0196	riboflavin kinase activity
AZF37_RS03835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AZF37_RS03845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AZF37_RS03850	COG2884	Cell division ATP-binding protein ftsE
AZF37_RS03855	COG1185	polyribonucleotide nucleotidyltransferase activity
AZF37_RS03875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AZF37_RS03880	COG1302	Protein conserved in bacteria
AZF37_RS03885	COG1461	Dihydroxyacetone kinase
AZF37_RS03890	COG0612	Peptidase, M16
AZF37_RS03895	COG0756	dUTP diphosphatase activity
AZF37_RS03915	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AZF37_RS03920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZF37_RS03935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AZF37_RS03940	COG0126	phosphoglycerate kinase activity
AZF37_RS03940	COG0149	triose-phosphate isomerase activity
AZF37_RS03950	COG0148	phosphopyruvate hydratase activity
AZF37_RS03955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AZF37_RS03960	COG0557	exoribonuclease II activity
AZF37_RS03965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AZF37_RS03975	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AZF37_RS03980	COG1074	ATP-dependent DNA helicase activity
AZF37_RS03985	COG1322	Protein conserved in bacteria
AZF37_RS03995	COG0534	Mate efflux family protein
AZF37_RS04005	COG2244	polysaccharide biosynthetic process
AZF37_RS04035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZF37_RS04045	COG1126	abc transporter atp-binding protein
AZF37_RS04055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZF37_RS04060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZF37_RS04065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AZF37_RS04070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AZF37_RS04075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AZF37_RS04080	COG0481	GTPase activity
AZF37_RS04085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZF37_RS04100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZF37_RS04110	COG3835	regulator
AZF37_RS04160	COG0439	Biotin carboxylase
AZF37_RS04235	COG0735	belongs to the Fur family
AZF37_RS04245	COG1121	(ABC) transporter
AZF37_RS04250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AZF37_RS04315	COG0517	IMP dehydrogenase activity
AZF37_RS04315	COG1125	glycine betaine transport
AZF37_RS04335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AZF37_RS04340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZF37_RS04340	COG0072	phenylalanine-tRNA ligase activity
AZF37_RS04350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AZF37_RS04355	COG0733	neurotransmitter:sodium symporter activity
AZF37_RS04380	COG1561	YicC-like family, N-terminal region
AZF37_RS04400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AZF37_RS04420	COG0826	peptidase U32
AZF37_RS04425	COG0826	peptidase U32
AZF37_RS04455	COG1193	negative regulation of DNA recombination
AZF37_RS04460	COG1193	negative regulation of DNA recombination
AZF37_RS04475	COG1193	negative regulation of DNA recombination
AZF37_RS04480	COG3481	metal-dependent phosphohydrolase, HD sub domain
AZF37_RS04485	COG0116	Belongs to the methyltransferase superfamily
AZF37_RS04495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AZF37_RS04510	COG1959	2 iron, 2 sulfur cluster binding
AZF37_RS04520	COG0822	iron-sulfur transferase activity
AZF37_RS04525	COG0358	DNA primase activity
AZF37_RS04530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AZF37_RS04535	COG1704	LemA family
AZF37_RS04550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AZF37_RS04565	COG1811	Na channel or pump
AZF37_RS04575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AZF37_RS04580	COG0242	peptide deformylase activity
AZF37_RS04585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AZF37_RS04590	COG2738	Putative neutral zinc metallopeptidase
AZF37_RS04600	COG0631	protein serine/threonine phosphatase activity
AZF37_RS04605	COG2815	serine threonine protein kinase
AZF37_RS04605	COG0515	serine threonine protein kinase
AZF37_RS04610	COG1162	GTPase activity
AZF37_RS04615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AZF37_RS04620	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AZF37_RS04625	COG0406	alpha-ribazole phosphatase activity
AZF37_RS04635	COG0742	ribosomal rna small subunit methyltransferase
AZF37_RS04645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AZF37_RS04655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AZF37_RS04660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AZF37_RS04670	COG1131	(ABC) transporter
AZF37_RS04695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AZF37_RS04700	COG0398	Pfam SNARE associated Golgi protein
AZF37_RS04720	COG1438	arginine binding
AZF37_RS04725	COG0497	DNA recombination
AZF37_RS04750	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AZF37_RS04760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZF37_RS04770	COG4122	O-methyltransferase activity
AZF37_RS04775	COG0019	diaminopimelate decarboxylase activity
AZF37_RS04780	COG1994	Peptidase M50
AZF37_RS04785	COG0180	Tryptophanyl-tRNA synthetase
AZF37_RS04795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AZF37_RS04800	COG4974	Belongs to the 'phage' integrase family
AZF37_RS04850	COG0460	homoserine dehydrogenase
AZF37_RS04860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AZF37_RS04865	COG0138	bifunctional purine biosynthesis protein purh
AZF37_RS04870	COG0138	bifunctional purine biosynthesis protein purh
AZF37_RS04895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AZF37_RS04900	COG0228	four-way junction DNA binding
AZF37_RS04910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AZF37_RS04915	COG0336	Belongs to the RNA methyltransferase TrmD family
AZF37_RS04920	COG0335	large ribosomal subunit rRNA binding
AZF37_RS04930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AZF37_RS04935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AZF37_RS04940	COG1187	pseudouridine synthase activity
AZF37_RS04950	COG2081	HI0933 family
AZF37_RS04960	COG0539	negative regulation of cytoplasmic translation
AZF37_RS04960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AZF37_RS04980	COG1181	Belongs to the D-alanine--D-alanine ligase family
AZF37_RS05005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZF37_RS05010	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AZF37_RS05015	COG1346	cytolysis
AZF37_RS05025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AZF37_RS05030	COG2011	ABC-type metal ion transport system permease component
AZF37_RS05035	COG1464	Belongs to the NlpA lipoprotein family
AZF37_RS05070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AZF37_RS05080	COG0133	tryptophan synthase activity
AZF37_RS05090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AZF37_RS05095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AZF37_RS05100	COG0124	histidyl-tRNA synthetase
AZF37_RS05105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZF37_RS05115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZF37_RS05120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AZF37_RS05125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AZF37_RS05130	COG1862	Preprotein translocase
AZF37_RS05135	COG0343	queuine tRNA-ribosyltransferase activity
AZF37_RS05155	COG0574	Belongs to the PEP-utilizing enzyme family
AZF37_RS05155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZF37_RS05160	COG0751	glycine-tRNA ligase activity
AZF37_RS05195	COG1381	Involved in DNA repair and RecF pathway recombination
AZF37_RS05200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AZF37_RS05205	COG0295	cytidine deaminase activity
AZF37_RS05210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AZF37_RS05230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZF37_RS05240	COG0537	adenosine 5'-monophosphoramidase activity
AZF37_RS05245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZF37_RS05250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AZF37_RS05255	COG2264	protein methyltransferase activity
AZF37_RS05270	COG0025	NhaP-type Na H and K H
AZF37_RS05275	COG0025	NhaP-type Na H and K H
AZF37_RS05280	COG0025	NhaP-type Na H and K H
AZF37_RS05305	COG1122	ATPase activity
AZF37_RS05310	COG1122	ATPase activity
AZF37_RS05315	COG1122	ATPase activity
AZF37_RS05330	COG0484	heat shock protein binding
AZF37_RS05335	COG0443	Heat shock 70 kDa protein
AZF37_RS05345	COG1420	regulation of RNA biosynthetic process
AZF37_RS05375	COG0140	phosphoribosyl-ATP diphosphatase activity
AZF37_RS05375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AZF37_RS05385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AZF37_RS05410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AZF37_RS05415	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AZF37_RS05420	COG4496	protein, YerC YecD
AZF37_RS05430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AZF37_RS05430	COG0316	Belongs to the HesB IscA family
AZF37_RS05440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AZF37_RS05455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZF37_RS05470	COG0306	phosphate transporter
AZF37_RS05475	COG0488	(ABC) transporter
AZF37_RS05500	COG1309	transcriptional regulator
AZF37_RS05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZF37_RS05535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AZF37_RS05540	COG1396	sequence-specific DNA binding
AZF37_RS05580	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AZF37_RS05585	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AZF37_RS05595	COG1982	Orn Lys Arg decarboxylase major
AZF37_RS05600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AZF37_RS05605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AZF37_RS05615	COG0740	serine-type endopeptidase activity
AZF37_RS05620	COG0544	peptidyl-prolyl cis-trans isomerase activity
AZF37_RS05640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AZF37_RS05645	COG1335	isochorismatase
AZF37_RS05655	COG0552	protein localization to endoplasmic reticulum
AZF37_RS05660	COG1196	nuclear chromosome segregation
AZF37_RS05665	COG0571	ribonuclease III activity
AZF37_RS05675	COG0586	Pfam SNARE associated Golgi protein
AZF37_RS05680	COG0142	geranyltranstransferase activity
AZF37_RS05690	COG1570	exodeoxyribonuclease VII activity
AZF37_RS05700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AZF37_RS05705	COG0493	'glutamate synthase
AZF37_RS05725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AZF37_RS05730	COG0006	proline dipeptidase activity
AZF37_RS05735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AZF37_RS05740	COG0312	modulator of DNA gyrase
AZF37_RS05750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AZF37_RS05760	COG0647	UMP catabolic process
AZF37_RS05765	COG0826	peptidase U32
AZF37_RS05775	COG3906	Belongs to the UPF0473 family
AZF37_RS05785	COG4472	Bacterial protein of unknown function (DUF965)
AZF37_RS05790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AZF37_RS05795	COG2359	stage V sporulation protein S
AZF37_RS05800	COG1692	metallophosphoesterase
AZF37_RS05805	COG1418	mRNA catabolic process
AZF37_RS05810	COG2137	regulation of response to DNA damage stimulus
AZF37_RS05825	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS05840	COG0268	Binds directly to 16S ribosomal RNA
AZF37_RS05875	COG0799	negative regulation of ribosome biogenesis
AZF37_RS05885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AZF37_RS05890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AZF37_RS05895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AZF37_RS05905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AZF37_RS05910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AZF37_RS05925	COG2076	Multidrug Resistance protein
AZF37_RS05955	COG0772	Belongs to the SEDS family
AZF37_RS05975	COG1077	Cell shape determining protein MreB Mrl
AZF37_RS05980	COG2003	Belongs to the UPF0758 family
AZF37_RS05985	COG2003	Belongs to the UPF0758 family
AZF37_RS06005	COG0285	dihydrofolate synthase activity
AZF37_RS06010	COG0525	valine-tRNA ligase activity
AZF37_RS06040	COG0166	Belongs to the GPI family
AZF37_RS06080	COG5002	protein histidine kinase activity
AZF37_RS06085	COG5002	protein histidine kinase activity
AZF37_RS06135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AZF37_RS06140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AZF37_RS06155	COG3935	DnaD domain protein
AZF37_RS06160	COG0436	Aminotransferase
AZF37_RS06165	COG0495	leucyl-tRNA aminoacylation
AZF37_RS06235	COG5012	cobalamin binding
AZF37_RS06275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AZF37_RS06280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZF37_RS06285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZF37_RS06295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZF37_RS06305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZF37_RS06310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZF37_RS06315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZF37_RS06325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZF37_RS06330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZF37_RS06350	COG4974	Belongs to the 'phage' integrase family
AZF37_RS06355	COG0426	domain, Protein
AZF37_RS06365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AZF37_RS06375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AZF37_RS06390	COG2233	PERMEase
AZF37_RS06395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AZF37_RS06400	COG4149	molybdate abc transporter
AZF37_RS06405	COG0725	ABC transporter, periplasmic molybdate-binding protein
AZF37_RS06420	COG2195	Cleaves the N-terminal amino acid of tripeptides
AZF37_RS06435	COG0741	lytic transglycosylase activity
AZF37_RS06480	COG1309	transcriptional regulator
AZF37_RS06485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AZF37_RS06560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AZF37_RS06635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AZF37_RS06660	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AZF37_RS06685	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS06690	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS06715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZF37_RS06750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AZF37_RS06775	COG1476	TRANSCRIPTIONal
AZF37_RS06785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AZF37_RS06795	COG2033	superoxide reductase activity
AZF37_RS06810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZF37_RS06820	COG0251	oxidation-reduction process
AZF37_RS06840	COG0463	Glycosyl transferase, family 2
AZF37_RS06870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AZF37_RS06895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AZF37_RS06920	COG1592	Rubrerythrin
AZF37_RS06935	COG0475	glutathione-regulated potassium exporter activity
AZF37_RS06940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZF37_RS06955	COG0372	Belongs to the citrate synthase family
AZF37_RS06980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AZF37_RS06990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AZF37_RS06995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AZF37_RS07005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AZF37_RS07040	COG1132	(ABC) transporter
AZF37_RS07045	COG0456	acetyltransferase
AZF37_RS07050	COG1214	PFAM Peptidase M22, glycoprotease
AZF37_RS07055	COG0802	atpase or kinase
AZF37_RS07060	COG1228	amidohydrolase
AZF37_RS07065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AZF37_RS07070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AZF37_RS07070	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AZF37_RS07075	COG0736	holo-[acyl-carrier-protein] synthase activity
AZF37_RS07185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AZF37_RS07195	COG1609	Transcriptional regulator
AZF37_RS07250	COG0577	efflux transmembrane transporter activity
AZF37_RS07300	COG2226	methyltransferase
AZF37_RS07325	COG1162	GTPase activity
AZF37_RS07355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZF37_RS07465	COG0205	6-phosphofructokinase activity
AZF37_RS07470	COG1307	EDD domain protein, DegV family
AZF37_RS07490	COG2233	PERMEase
AZF37_RS07495	COG2233	PERMEase
AZF37_RS07500	COG2233	PERMEase
AZF37_RS07565	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS07575	COG0402	S-adenosylhomocysteine deaminase activity
AZF37_RS07625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AZF37_RS07630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AZF37_RS07635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AZF37_RS07650	COG2801	Transposase and inactivated derivatives
AZF37_RS07655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZF37_RS07660	COG0154	amidase activity
AZF37_RS07665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZF37_RS07670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AZF37_RS07690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AZF37_RS07695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AZF37_RS07700	COG2183	response to ionizing radiation
AZF37_RS07705	COG0237	dephospho-CoA kinase activity
AZF37_RS07710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AZF37_RS07715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AZF37_RS07715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AZF37_RS07735	COG1079	Belongs to the binding-protein-dependent transport system permease family
AZF37_RS07745	COG4603	Belongs to the binding-protein-dependent transport system permease family
AZF37_RS07750	COG3845	ABC transporter
AZF37_RS07755	COG3845	ABC transporter
AZF37_RS07760	COG3845	ABC transporter
AZF37_RS07765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AZF37_RS07770	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AZF37_RS07805	COG1876	peptidase activity
AZF37_RS07825	COG0367	asparagine synthase
AZF37_RS07840	COG0492	ferredoxin-NADP+ reductase activity
AZF37_RS07845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZF37_RS07865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AZF37_RS07900	COG1177	transmembrane transport
AZF37_RS07920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZF37_RS07925	COG1595	DNA-templated transcription, initiation
AZF37_RS07935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZF37_RS07940	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AZF37_RS07950	COG0215	cysteine-tRNA ligase activity
AZF37_RS07955	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AZF37_RS07965	COG4956	integral membrane protein (PIN domain superfamily)
AZF37_RS07970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AZF37_RS07975	COG1408	metallophosphoesterase
AZF37_RS07990	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AZF37_RS08015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AZF37_RS08060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AZF37_RS08060	COG1013	pyruvate-flavodoxin oxidoreductase activity
AZF37_RS08060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZF37_RS08060	COG0674	pyruvate-flavodoxin oxidoreductase activity
AZF37_RS08065	COG0538	isocitrate dehydrogenase activity
AZF37_RS08070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AZF37_RS08075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AZF37_RS08085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AZF37_RS08090	COG1368	sulfuric ester hydrolase activity
AZF37_RS08150	COG1924	4 iron, 4 sulfur cluster binding
AZF37_RS08155	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AZF37_RS08275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AZF37_RS08280	COG2252	PERMEase
AZF37_RS08340	COG1968	undecaprenyl-diphosphatase activity
AZF37_RS08345	COG0084	hydrolase, TatD family'
AZF37_RS08350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZF37_RS08350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZF37_RS08360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AZF37_RS08365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AZF37_RS08375	COG1774	PSP1 C-terminal conserved region
AZF37_RS08385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AZF37_RS08405	COG1982	Orn Lys Arg decarboxylase major
AZF37_RS08410	COG0626	cystathionine gamma-synthase activity
AZF37_RS08445	COG0436	Aminotransferase
AZF37_RS08490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AZF37_RS08500	COG0322	excinuclease ABC activity
AZF37_RS08505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AZF37_RS08535	COG0514	ATP-dependent DNA helicase (RecQ)
AZF37_RS08540	COG2217	Heavy metal translocating P-type atpase
AZF37_RS08550	COG1597	lipid kinase activity
AZF37_RS08565	COG0629	single-stranded DNA binding
AZF37_RS08570	COG4481	Protein conserved in bacteria
AZF37_RS08615	COG2184	nucleotidyltransferase activity
AZF37_RS08625	COG1546	Belongs to the CinA family
AZF37_RS08625	COG1058	Belongs to the CinA family
AZF37_RS08635	COG0191	fructose-bisphosphate aldolase activity
AZF37_RS08655	COG2233	PERMEase
AZF37_RS08665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AZF37_RS08670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AZF37_RS08695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZF37_RS08700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZF37_RS08705	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AZF37_RS08710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AZF37_RS08755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AZF37_RS08760	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AZF37_RS08780	COG2188	Transcriptional regulator
AZF37_RS08785	COG0360	Binds together with S18 to 16S ribosomal RNA
AZF37_RS08790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AZF37_RS08800	COG0359	binds to the 23S rRNA
AZF37_RS08805	COG0305	Participates in initiation and elongation during chromosome replication
AZF37_RS08810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AZF37_RS08855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AZF37_RS08860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZF37_RS08865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZF37_RS08870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZF37_RS08920	COG2378	regulation of single-species biofilm formation
AZF37_RS08925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AZF37_RS08965	COG1309	transcriptional regulator
AZF37_RS09065	COG0789	Transcriptional regulator
AZF37_RS09070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AZF37_RS09075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AZF37_RS09080	COG0187	DNA topoisomerase II activity
AZF37_RS09105	COG1918	ferrous iron import across plasma membrane
AZF37_RS09105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AZF37_RS09110	COG1979	alcohol dehydrogenase
AZF37_RS09115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AZF37_RS09115	COG3608	succinylglutamate desuccinylase aspartoacylase
AZF37_RS09155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AZF37_RS09165	COG0706	membrane insertase activity
AZF37_RS09175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AZF37_RS09180	COG0445	tRNA wobble uridine modification
AZF37_RS09185	COG0357	Ribosomal RNA small subunit methyltransferase G
AZF37_RS09295	COG1902	pentaerythritol trinitrate reductase activity
AZF37_RS09300	COG1902	pentaerythritol trinitrate reductase activity
AZF37_RS09315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AZF37_RS09320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AZF37_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
AZF37_RS09330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AZF37_RS09335	COG2070	2-Nitropropane dioxygenase
AZF37_RS09340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZF37_RS09345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AZF37_RS09350	COG0825	malonyl-CoA metabolic process
AZF37_RS09355	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AZF37_RS09355	COG0825	malonyl-CoA metabolic process
AZF37_RS09360	COG0439	Biotin carboxylase
AZF37_RS09365	COG0511	ligase activity, forming carbon-carbon bonds
AZF37_RS09370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZF37_RS09375	COG0321	lipoyl(octanoyl) transferase activity
AZF37_RS09395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AZF37_RS09400	COG0105	UTP biosynthetic process
AZF37_RS09410	COG0037	tRNA processing
AZF37_RS09450	COG1098	S1 RNA binding domain
AZF37_RS09465	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AZF37_RS09490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AZF37_RS09505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AZF37_RS09510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AZF37_RS09570	COG1573	uracil-dna glycosylase
AZF37_RS09595	COG2177	Part of the ABC transporter FtsEX involved in
AZF37_RS09600	COG2884	Cell division ATP-binding protein ftsE
AZF37_RS09605	COG3958	Transketolase
AZF37_RS09610	COG3959	Transketolase, thiamine diphosphate binding domain
AZF37_RS09655	COG0653	protein targeting
AZF37_RS09660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AZF37_RS09665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AZF37_RS09675	COG0572	uridine kinase
AZF37_RS09685	COG0564	pseudouridine synthase activity
AZF37_RS09690	COG0564	pseudouridine synthase activity
AZF37_RS09695	COG0513	Belongs to the DEAD box helicase family
AZF37_RS09730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AZF37_RS09740	COG0101	tRNA pseudouridine synthase activity
AZF37_RS09745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AZF37_RS09755	COG1122	ATPase activity
AZF37_RS09850	COG1192	Involved in chromosome partitioning
AZF37_RS09855	COG1475	DNA binding
AZF37_RS09860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AZF37_RS09865	COG1921	L-seryl-tRNASec selenium transferase activity
AZF37_RS09900	COG0509	glycine decarboxylation via glycine cleavage system
AZF37_RS09945	COG0860	N-Acetylmuramoyl-L-alanine amidase
AZF37_RS10040	COG4626	Terminase
AZF37_RS10040	COG1802	Transcriptional regulator
AZF37_RS10085	COG0733	neurotransmitter:sodium symporter activity