locus-tag	class	description
I862_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I862_RS00015	COG0052	Belongs to the universal ribosomal protein uS2 family
I862_RS00020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I862_RS00030	COG0233	cytoplasmic translational termination
I862_RS00050	COG0793	Belongs to the peptidase S41A family
I862_RS00055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I862_RS00065	COG1749	Flagellar hook protein flgE
I862_RS00070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I862_RS00075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I862_RS00090	COG4120	Belongs to the binding-protein-dependent transport system permease family
I862_RS00125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I862_RS00155	COG2204	response regulator
I862_RS00170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I862_RS00175	COG1040	competence protein
I862_RS00180	COG2226	methyltransferase
I862_RS00195	COG0181	hydroxymethylbilane synthase activity
I862_RS00205	COG2094	Belongs to the DNA glycosylase MPG family
I862_RS00220	COG0268	Binds directly to 16S ribosomal RNA
I862_RS00225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I862_RS00235	COG1566	PFAM secretion protein HlyD family protein
I862_RS00240	COG2814	Major facilitator Superfamily
I862_RS00245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I862_RS00250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I862_RS00255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I862_RS00265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I862_RS00270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I862_RS00275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I862_RS00295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I862_RS00305	COG0039	L-malate dehydrogenase activity
I862_RS00315	COG0666	response to abiotic stimulus
I862_RS00320	COG2027	D-alanyl-D-alanine carboxypeptidase
I862_RS00330	COG0795	lipopolysaccharide-transporting ATPase activity
I862_RS00335	COG0542	response to heat
I862_RS00370	COG1230	cation diffusion facilitator family transporter
I862_RS00390	COG1217	gtp-binding protein TYPA
I862_RS00400	COG4770	biotin carboxylase activity
I862_RS00415	COG1011	Hydrolase
I862_RS00430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I862_RS00445	COG0348	domain, Protein
I862_RS00455	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I862_RS00490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I862_RS00500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I862_RS00500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I862_RS00510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I862_RS00510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I862_RS00535	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I862_RS00550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I862_RS00550	COG0456	acetyltransferase
I862_RS00560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I862_RS00565	COG0740	serine-type endopeptidase activity
I862_RS00570	COG0544	peptidyl-prolyl cis-trans isomerase activity
I862_RS00575	COG2217	Heavy metal translocating P-type atpase
I862_RS00600	COG2003	Belongs to the UPF0758 family
I862_RS00605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I862_RS00625	COG1131	(ABC) transporter
I862_RS00630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I862_RS00640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I862_RS00650	COG2823	Periplasmic or secreted lipoprotein
I862_RS00655	COG2823	Periplasmic or secreted lipoprotein
I862_RS00670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I862_RS00675	COG3178	'Phosphotransferase
I862_RS00685	COG0321	lipoyl(octanoyl) transferase activity
I862_RS00695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I862_RS00700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I862_RS00705	COG1573	uracil-dna glycosylase
I862_RS00715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I862_RS00720	COG4589	Belongs to the CDS family
I862_RS00725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I862_RS00745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I862_RS00755	COG0508	dehydrogenase complex catalyzes the overall conversion of
I862_RS00765	COG0531	amino acid
I862_RS00770	COG0071	Belongs to the small heat shock protein (HSP20) family
I862_RS00795	COG1074	ATP-dependent DNA helicase activity
I862_RS00800	COG3220	belongs to the UPF0276 family
I862_RS00810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I862_RS00825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I862_RS00830	COG0723	plastoquinol--plastocyanin reductase activity
I862_RS00850	COG0484	heat shock protein binding
I862_RS00860	COG2155	Conserved Protein
I862_RS00880	COG0783	Belongs to the Dps family
I862_RS00885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I862_RS00905	COG0779	Required for maturation of 30S ribosomal subunits
I862_RS00910	COG1218	3'(2'),5'-bisphosphate nucleotidase
I862_RS00915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I862_RS00930	COG4285	Biotin-protein ligase, N terminal
I862_RS00935	COG5002	protein histidine kinase activity
I862_RS00940	COG4067	protein conserved in archaea
I862_RS00940	COG0189	ligase activity
I862_RS00945	COG1214	PFAM Peptidase M22, glycoprotease
I862_RS00960	COG1331	Highly conserved protein containing a thioredoxin domain
I862_RS00970	COG0723	plastoquinol--plastocyanin reductase activity
I862_RS01015	COG4974	Belongs to the 'phage' integrase family
I862_RS01020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I862_RS01030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I862_RS01040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I862_RS01070	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I862_RS01090	COG0242	peptide deformylase activity
I862_RS01095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I862_RS01110	COG1278	Cold shock
I862_RS01140	COG0776	regulation of translation
I862_RS01145	COG0616	signal peptide processing
I862_RS01165	COG1012	belongs to the aldehyde dehydrogenase family
I862_RS01170	COG0823	Involved in the tonB-independent uptake of proteins
I862_RS01175	COG1942	4-Oxalocrotonate Tautomerase
I862_RS01180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I862_RS01195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I862_RS01200	COG0571	ribonuclease III activity
I862_RS01205	COG0681	Belongs to the peptidase S26 family
I862_RS01225	COG0590	tRNA wobble adenosine to inosine editing
I862_RS01230	COG2211	Major facilitator Superfamily
I862_RS01235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I862_RS01250	COG0488	(ABC) transporter
I862_RS01260	COG1187	pseudouridine synthase activity
I862_RS01265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I862_RS01285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I862_RS01285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I862_RS01300	COG0745	RESPONSE REGULATOR receiver
I862_RS01385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I862_RS01485	COG0285	dihydrofolate synthase activity
I862_RS01490	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I862_RS01495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I862_RS01520	COG1034	ATP synthesis coupled electron transport
I862_RS01525	COG0655	NAD(P)H dehydrogenase (quinone) activity
I862_RS01530	COG2814	Major facilitator Superfamily
I862_RS01545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I862_RS01545	COG2890	protein-(glutamine-N5) methyltransferase activity
I862_RS01550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I862_RS01555	COG0745	RESPONSE REGULATOR receiver
I862_RS01560	COG1396	sequence-specific DNA binding
I862_RS01565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I862_RS01590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I862_RS01615	COG0805	protein transport
I862_RS01655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I862_RS01660	COG1357	PFAM Pentapeptide repeats (8 copies)
I862_RS01700	COG1722	exodeoxyribonuclease VII activity
I862_RS01725	COG3660	Nucleoside-diphosphate-sugar epimerase
I862_RS01730	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I862_RS01775	COG1459	type II secretion system
I862_RS01780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I862_RS01790	COG0101	tRNA pseudouridine synthase activity
I862_RS01795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I862_RS01795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I862_RS01800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I862_RS01805	COG0666	response to abiotic stimulus
I862_RS01810	COG0156	8-amino-7-oxononanoate synthase activity
I862_RS01820	COG0124	histidyl-tRNA synthetase
I862_RS01825	COG1192	Involved in chromosome partitioning
I862_RS01860	COG0849	cell division
I862_RS01870	COG1181	Belongs to the D-alanine--D-alanine ligase family
I862_RS01885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I862_RS01890	COG0424	maF-like protein
I862_RS01900	COG0045	succinate-CoA ligase (ADP-forming) activity
I862_RS01910	COG0742	ribosomal rna small subunit methyltransferase
I862_RS01925	COG2801	Transposase and inactivated derivatives
I862_RS01930	COG2963	transposase activity
I862_RS01975	COG1376	ErfK ybiS ycfS ynhG family protein
I862_RS01980	COG2801	Transposase and inactivated derivatives
I862_RS01985	COG2963	transposase activity
I862_RS02020	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I862_RS02040	COG1819	glycosyl
I862_RS02085	COG2801	Transposase and inactivated derivatives
I862_RS02095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I862_RS02095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I862_RS02105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I862_RS02110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I862_RS02115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I862_RS02175	COG5002	protein histidine kinase activity
I862_RS02180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I862_RS02190	COG0517	IMP dehydrogenase activity
I862_RS02190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I862_RS02215	COG1970	mechanosensitive ion channel activity
I862_RS02225	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I862_RS02240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I862_RS02250	COG1862	Preprotein translocase
I862_RS02255	COG2226	methyltransferase
I862_RS02260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I862_RS02265	COG1360	Flagellar Motor Protein
I862_RS02275	COG0471	metal ion transport
I862_RS02335	COG1073	alpha beta
I862_RS02340	COG0492	ferredoxin-NADP+ reductase activity
I862_RS02345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I862_RS02350	COG1295	ribonuclease BN
I862_RS02370	COG0708	Exodeoxyribonuclease III
I862_RS02375	COG5464	transposase or invertase
I862_RS02385	COG0556	nucleotide-excision repair
I862_RS02400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I862_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
I862_RS02420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I862_RS02435	COG0728	peptidoglycan biosynthetic process
I862_RS02440	COG0335	large ribosomal subunit rRNA binding
I862_RS02445	COG0336	Belongs to the RNA methyltransferase TrmD family
I862_RS02455	COG0228	four-way junction DNA binding
I862_RS02475	COG0489	protein tyrosine kinase activity
I862_RS02480	COG0330	HflC and HflK could
I862_RS02510	COG1959	2 iron, 2 sulfur cluster binding
I862_RS02525	COG4133	protoheme IX ABC transporter activity
I862_RS02530	COG1132	(ABC) transporter
I862_RS02535	COG1530	ribonuclease E activity
I862_RS02545	COG0193	aminoacyl-tRNA hydrolase activity
I862_RS02550	COG0012	GTP binding
I862_RS02570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I862_RS02615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I862_RS02620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I862_RS02625	COG1494	fructose-1,6-bisphosphatase
I862_RS02640	COG0473	3-isopropylmalate dehydrogenase activity
I862_RS02645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I862_RS02650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I862_RS02675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I862_RS02680	COG3307	-O-antigen
I862_RS02780	COG4695	Portal protein
I862_RS02830	COG0604	alcohol dehydrogenase
I862_RS02835	COG0612	Peptidase, M16
I862_RS02850	COG0281	malic enzyme
I862_RS02850	COG0280	phosphate acetyltransferase
I862_RS02855	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I862_RS02865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I862_RS02880	COG1381	Involved in DNA repair and RecF pathway recombination
I862_RS02890	COG0776	regulation of translation
I862_RS02895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I862_RS02900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I862_RS02905	COG4974	Belongs to the 'phage' integrase family
I862_RS02915	COG0009	L-threonylcarbamoyladenylate synthase
I862_RS02930	COG1007	ATP synthesis coupled electron transport
I862_RS02945	COG0713	ATP synthesis coupled electron transport
I862_RS02975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I862_RS03025	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I862_RS03060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I862_RS03065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I862_RS03115	COG1053	succinate dehydrogenase
I862_RS03120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I862_RS03125	COG2009	succinate dehydrogenase
I862_RS03135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I862_RS03145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I862_RS03210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I862_RS03220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I862_RS03250	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I862_RS03255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I862_RS03270	COG3243	poly(R)-hydroxyalkanoic acid synthase
I862_RS03280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I862_RS03285	COG2917	probably involved in intracellular septation
I862_RS03305	COG0531	amino acid
I862_RS03320	COG0384	phenazine biosynthesis protein PhzF
I862_RS03325	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I862_RS03335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I862_RS03340	COG1987	bacterial-type flagellum assembly
I862_RS03355	COG0504	CTP synthase activity
I862_RS03365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I862_RS03370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I862_RS03395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I862_RS03415	COG1132	(ABC) transporter
I862_RS03420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I862_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
I862_RS03430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I862_RS03445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I862_RS03450	COG2171	N-acyltransferase activity
I862_RS03495	COG0697	spore germination
I862_RS03505	COG4251	negative regulation of phosphorylation
I862_RS03525	COG3202	ADP transmembrane transporter activity
I862_RS03535	COG0606	chelatase, subunit chli
I862_RS03540	COG2205	protein histidine kinase activity
I862_RS03560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I862_RS03565	COG0085	RNA polymerase activity
I862_RS03570	COG0222	ribosome binding
I862_RS03575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I862_RS03580	COG0081	regulation of translation
I862_RS03585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I862_RS03605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I862_RS03620	COG1137	ATPase activity
I862_RS03630	COG0543	2 iron, 2 sulfur cluster binding
I862_RS03630	COG0493	'glutamate synthase
I862_RS03635	COG1872	DUF167
I862_RS03640	COG1706	bacterial-type flagellum-dependent cell motility
I862_RS03670	COG0752	glycyl-tRNA synthetase alpha subunit
I862_RS03700	COG4106	trans-aconitate 2-methyltransferase activity
I862_RS03715	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I862_RS03725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I862_RS03730	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I862_RS03745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I862_RS03750	COG1136	(ABC) transporter
I862_RS03755	COG2255	four-way junction helicase activity
I862_RS03765	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I862_RS03785	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I862_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
I862_RS03805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I862_RS03840	COG0189	ligase activity
I862_RS03855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I862_RS03865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I862_RS03875	COG1301	dicarboxylic acid transport
I862_RS03900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I862_RS03905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I862_RS03915	COG0495	leucyl-tRNA aminoacylation
I862_RS03925	COG0113	porphobilinogen synthase activity
I862_RS03945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I862_RS03960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I862_RS03965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I862_RS03970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I862_RS03980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I862_RS03985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I862_RS03990	COG0142	geranyltranstransferase activity
I862_RS03995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I862_RS04000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I862_RS04005	COG0792	nuclease activity
I862_RS04020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I862_RS04030	COG1560	Kdo2-lipid A biosynthetic process
I862_RS04040	COG1686	Belongs to the peptidase S11 family
I862_RS04060	COG2814	Major facilitator Superfamily
I862_RS04080	COG2205	protein histidine kinase activity
I862_RS04080	COG2202	Pas domain
I862_RS04085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I862_RS04090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I862_RS04095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I862_RS04105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I862_RS04110	COG2205	protein histidine kinase activity
I862_RS04115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I862_RS04120	COG0166	Belongs to the GPI family
I862_RS04125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I862_RS04170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I862_RS04190	COG0745	RESPONSE REGULATOR receiver
I862_RS04195	COG3621	Patatin-like phospholipase
I862_RS04200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I862_RS04205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I862_RS04220	COG4974	Belongs to the 'phage' integrase family
I862_RS04375	COG0616	signal peptide processing
I862_RS04400	COG1475	DNA binding
I862_RS04470	COG2801	Transposase and inactivated derivatives
I862_RS04520	COG1338	Plays a role in the flagellum-specific transport system
I862_RS04530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I862_RS04540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I862_RS04545	COG0494	nUDIX hydrolase
I862_RS04550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I862_RS04555	COG0629	single-stranded DNA binding
I862_RS04570	COG0799	negative regulation of ribosome biogenesis
I862_RS04575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I862_RS04580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I862_RS04590	COG0768	penicillin binding
I862_RS04605	COG0302	gtp cyclohydrolase
I862_RS04625	COG2205	protein histidine kinase activity
I862_RS04625	COG0784	Response regulator, receiver
I862_RS04655	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I862_RS04660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I862_RS04665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I862_RS04685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I862_RS04695	COG3577	Aspartyl protease
I862_RS04705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I862_RS04715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I862_RS04720	COG1253	flavin adenine dinucleotide binding
I862_RS04725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I862_RS04730	COG1702	phosphate starvation-inducible protein PhoH
I862_RS04750	COG1686	Belongs to the peptidase S11 family
I862_RS04755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I862_RS04795	COG3736	Type IV secretory pathway, component VirB8
I862_RS04805	COG2948	multi-organism process
I862_RS04825	COG1294	oxidase, subunit
I862_RS04830	COG1271	oxidase subunit
I862_RS04855	COG2963	transposase activity
I862_RS04860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I862_RS04865	COG1132	(ABC) transporter
I862_RS04875	COG1054	Belongs to the UPF0176 family
I862_RS04880	COG1253	flavin adenine dinucleotide binding
I862_RS04890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I862_RS04910	COG1570	exodeoxyribonuclease VII activity
I862_RS04915	COG4786	Flagellar basal body rod
I862_RS04920	COG4786	Flagellar basal body rod
I862_RS04930	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I862_RS04935	COG0358	DNA primase activity
I862_RS04955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I862_RS04975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I862_RS05000	COG1815	bacterial-type flagellum-dependent cell motility
I862_RS05005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I862_RS05025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I862_RS05035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I862_RS05040	COG0416	fatty acid biosynthetic process
I862_RS05045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I862_RS05085	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I862_RS05095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I862_RS05110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I862_RS05115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I862_RS05120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I862_RS05125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I862_RS05130	COG1185	polyribonucleotide nucleotidyltransferase activity
I862_RS05140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I862_RS05155	COG0508	dehydrogenase complex catalyzes the overall conversion of
I862_RS05160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I862_RS05185	COG2902	Dehydrogenase
I862_RS05195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I862_RS05230	COG0443	Heat shock 70 kDa protein
I862_RS05260	COG0745	RESPONSE REGULATOR receiver
I862_RS05265	COG0745	RESPONSE REGULATOR receiver
I862_RS05285	COG2165	general secretion pathway protein
I862_RS05295	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I862_RS05295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I862_RS05305	COG1546	Belongs to the CinA family
I862_RS05305	COG1058	Belongs to the CinA family
I862_RS05315	COG1472	Belongs to the glycosyl hydrolase 3 family
I862_RS05375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I862_RS05395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I862_RS05400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I862_RS05415	COG0450	alkyl hydroperoxide reductase
I862_RS05420	COG0492	ferredoxin-NADP+ reductase activity
I862_RS05445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I862_RS05460	COG2204	response regulator
I862_RS05470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I862_RS05480	COG1215	transferase activity, transferring glycosyl groups
I862_RS05485	COG2867	negative regulation of translational initiation
I862_RS05490	COG1426	Protein conserved in bacteria
I862_RS05500	COG0126	phosphoglycerate kinase activity
I862_RS05505	COG1714	RDD family
I862_RS05520	COG1450	Type ii and iii secretion system protein
I862_RS05535	COG0736	holo-[acyl-carrier-protein] synthase activity
I862_RS05550	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I862_RS05565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I862_RS05585	COG1132	(ABC) transporter
I862_RS05590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I862_RS05610	COG0105	UTP biosynthetic process
I862_RS05615	COG0527	aspartate kinase activity
I862_RS05620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I862_RS05625	COG4520	surface antigen
I862_RS05640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I862_RS05645	COG0463	Glycosyl transferase, family 2
I862_RS05650	COG0237	dephospho-CoA kinase activity
I862_RS05655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I862_RS05670	COG1472	Belongs to the glycosyl hydrolase 3 family
I862_RS05680	COG0463	Glycosyl transferase, family 2
I862_RS05685	COG0477	Major facilitator Superfamily
I862_RS05690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I862_RS05705	COG0326	Molecular chaperone. Has ATPase activity
I862_RS05725	COG0018	arginyl-trna synthetase
I862_RS05730	COG2271	Major facilitator Superfamily
I862_RS05745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I862_RS05750	COG2885	chlorophyll binding
I862_RS05755	COG0204	Acyl-transferase
I862_RS05795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I862_RS05810	COG0203	ribosomal protein L17
I862_RS05820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I862_RS05825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I862_RS05830	COG0563	adenylate kinase activity
I862_RS05835	COG0201	protein transport
I862_RS05845	COG1841	ribosomal large subunit assembly
I862_RS05860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I862_RS05865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I862_RS05870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I862_RS05875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I862_RS05880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I862_RS05895	COG0255	Belongs to the universal ribosomal protein uL29 family
I862_RS05900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I862_RS05905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I862_RS05910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I862_RS05915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I862_RS05920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I862_RS05925	COG0089	rRNA binding
I862_RS05930	COG0088	Forms part of the polypeptide exit tunnel
I862_RS05935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I862_RS05940	COG0051	transcription antitermination factor activity, RNA binding
I862_RS05945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I862_RS05960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I862_RS05965	COG1192	Involved in chromosome partitioning
I862_RS05970	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I862_RS05980	COG0354	folic acid binding
I862_RS06000	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I862_RS06005	COG0802	atpase or kinase
I862_RS06010	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I862_RS06025	COG0598	Magnesium transport protein CorA
I862_RS06030	COG0359	binds to the 23S rRNA
I862_RS06035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I862_RS06040	COG0360	Binds together with S18 to 16S ribosomal RNA
I862_RS06045	COG0321	lipoyl(octanoyl) transferase activity
I862_RS06045	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I862_RS06050	COG0084	hydrolase, TatD family'
I862_RS06055	COG0776	regulation of translation
I862_RS06070	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I862_RS06080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I862_RS06085	COG0180	Tryptophanyl-tRNA synthetase
I862_RS06090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I862_RS06090	COG2857	Cytochrome c1
I862_RS06095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I862_RS06100	COG0670	Belongs to the BI1 family
I862_RS06115	COG0330	HflC and HflK could
I862_RS06135	COG3278	Belongs to the heme-copper respiratory oxidase family
I862_RS06155	COG0776	regulation of translation
I862_RS06160	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
I862_RS06170	COG0649	NAD binding
I862_RS06175	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I862_RS06180	COG0758	DNA mediated transformation
I862_RS06190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I862_RS06200	COG1519	Transferase
I862_RS06205	COG1663	tetraacyldisaccharide 4'-kinase activity
I862_RS06215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I862_RS06220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I862_RS06230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I862_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
I862_RS06275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I862_RS06280	COG0142	geranyltranstransferase activity
I862_RS06295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I862_RS06305	COG0436	Aminotransferase
I862_RS06310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I862_RS06320	COG0316	Belongs to the HesB IscA family
I862_RS06325	COG0822	iron-sulfur transferase activity
I862_RS06335	COG1104	cysteine desulfurase activity
I862_RS06340	COG1959	2 iron, 2 sulfur cluster binding
I862_RS06345	COG2945	thiolester hydrolase activity
I862_RS06350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I862_RS06360	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I862_RS06385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I862_RS06390	COG0750	zinc metalloprotease
I862_RS06415	COG2801	Transposase and inactivated derivatives
I862_RS06450	COG0564	pseudouridine synthase activity
I862_RS06460	COG3088	subunit of a heme lyase
I862_RS06475	COG3202	ADP transmembrane transporter activity
I862_RS06480	COG1368	sulfuric ester hydrolase activity
I862_RS06500	COG3704	protein secretion by the type IV secretion system
I862_RS06505	COG3704	protein secretion by the type IV secretion system
I862_RS06515	COG3451	type IV secretory pathway VirB4
I862_RS06540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I862_RS06545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I862_RS06555	COG5002	protein histidine kinase activity
I862_RS06635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I862_RS06640	COG0594	ribonuclease P activity
I862_RS06645	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I862_RS06650	COG1573	uracil-dna glycosylase
I862_RS06655	COG0196	riboflavin kinase activity
I862_RS06660	COG1674	ftsk spoiiie
I862_RS06665	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I862_RS06670	COG0617	tRNA 3'-terminal CCA addition
I862_RS06675	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I862_RS06685	COG0022	dehydrogenase e1 component
I862_RS06690	COG1132	(ABC) transporter
I862_RS06695	COG1252	NADH dehydrogenase
I862_RS06700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I862_RS06775	COG0488	(ABC) transporter
I862_RS06790	COG0217	transcriptional regulatory protein
I862_RS06795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I862_RS06800	COG0628	permease
I862_RS06805	COG3750	Belongs to the UPF0335 family
I862_RS06820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I862_RS06830	COG0174	glutamine synthetase
I862_RS06835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I862_RS06840	COG0741	lytic transglycosylase activity
I862_RS06855	COG0357	Ribosomal RNA small subunit methyltransferase G
I862_RS06860	COG1192	Involved in chromosome partitioning
I862_RS06885	COG4496	protein, YerC YecD
I862_RS06915	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I862_RS06920	COG0305	Participates in initiation and elongation during chromosome replication
I862_RS06950	COG1981	membrane
I862_RS06970	COG0024	Methionine aminopeptidase
I862_RS06980	COG0187	DNA topoisomerase II activity
I862_RS06990	COG0114	fumarate hydratase activity
I862_RS06995	COG0154	amidase activity
I862_RS07010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I862_RS07015	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I862_RS07030	COG4942	peptidase
I862_RS07030	COG4942	peptidase
I862_RS07040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I862_RS07055	COG0149	triose-phosphate isomerase activity
I862_RS07080	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I862_RS07085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I862_RS07105	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I862_RS07110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I862_RS07115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I862_RS07120	COG1438	arginine binding
I862_RS07125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I862_RS07130	COG0765	amino acid transport
I862_RS07135	COG1126	abc transporter atp-binding protein
I862_RS07155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I862_RS07170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I862_RS07170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I862_RS07175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I862_RS07180	COG0751	glycine-tRNA ligase activity
I862_RS07195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I862_RS07240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I862_RS07260	COG1138	Cytochrome C-type biogenesis protein
I862_RS07265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I862_RS07295	COG1696	Membrane protein involved in D-alanine export
I862_RS07370	COG2814	Major facilitator Superfamily
I862_RS07400	COG2337	Toxic component of a toxin-antitoxin (TA) module
I862_RS07450	COG1475	DNA binding
I862_RS07480	COG0666	response to abiotic stimulus
I862_RS07550	COG0653	protein targeting
I862_RS07565	COG4974	Belongs to the 'phage' integrase family
I862_RS07575	COG0666	response to abiotic stimulus
I862_RS07580	COG0443	Heat shock 70 kDa protein
I862_RS07595	COG0697	spore germination
I862_RS07635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I862_RS07645	COG3494	Protein of unknown function (DUF1009)
I862_RS07655	COG0539	negative regulation of cytoplasmic translation
I862_RS07670	COG0308	aminopeptidase N
I862_RS07685	COG0484	heat shock protein binding
I862_RS07730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I862_RS07740	COG0484	heat shock protein binding
I862_RS07760	COG1193	negative regulation of DNA recombination
I862_RS07805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I862_RS07820	COG0170	dolichyl monophosphate biosynthetic process
I862_RS07850	COG2205	protein histidine kinase activity
I862_RS07850	COG2202	Pas domain
I862_RS07860	COG0666	response to abiotic stimulus
I862_RS07865	COG0254	rRNA binding
I862_RS07870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I862_RS07885	COG0358	DNA primase activity
I862_RS07895	COG1677	Flagellar hook-basal body complex protein FliE
I862_RS07920	COG3827	peptidoglycan binding
I862_RS07925	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I862_RS07930	COG3657	addiction module killer protein
I862_RS07935	COG3474	cytochrome
I862_RS07940	COG0415	Belongs to the DNA photolyase family
I862_RS07945	COG0415	Belongs to the DNA photolyase family
I862_RS07965	COG2200	EAL domain
I862_RS07990	COG2205	protein histidine kinase activity
I862_RS07990	COG2202	Pas domain
I862_RS08000	COG0666	response to abiotic stimulus