locus-tag	class	description
AXH84_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXH84_RS00010	COG0592	DNA-directed DNA polymerase activity
AXH84_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXH84_RS00035	COG1793	dna ligase
AXH84_RS00045	COG0495	leucyl-tRNA aminoacylation
AXH84_RS00050	COG0167	dihydroorotate dehydrogenase activity
AXH84_RS00055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AXH84_RS00065	COG0625	glutathione transferase activity
AXH84_RS00070	COG2857	Cytochrome c1
AXH84_RS00075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AXH84_RS00080	COG0723	plastoquinol--plastocyanin reductase activity
AXH84_RS00090	COG0653	protein targeting
AXH84_RS00095	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AXH84_RS00105	COG0418	dihydroorotase activity
AXH84_RS00115	COG0196	riboflavin kinase activity
AXH84_RS00120	COG1194	a g-specific adenine glycosylase
AXH84_RS00125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AXH84_RS00135	COG0436	Aminotransferase
AXH84_RS00150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXH84_RS00160	COG0741	lytic transglycosylase activity
AXH84_RS00160	COG1196	nuclear chromosome segregation
AXH84_RS00160	COG0739	heme binding
AXH84_RS00165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AXH84_RS00170	COG0575	Belongs to the CDS family
AXH84_RS00195	COG0107	imidazoleglycerol-phosphate synthase activity
AXH84_RS00205	COG0109	protoheme IX farnesyltransferase activity
AXH84_RS00215	COG1612	heme a metabolic process
AXH84_RS00225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXH84_RS00230	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AXH84_RS00235	COG1845	cytochrome c oxidase, subunit III
AXH84_RS00270	COG1674	ftsk spoiiie
AXH84_RS00275	COG0492	ferredoxin-NADP+ reductase activity
AXH84_RS00285	COG3079	Belongs to the UPF0149 family
AXH84_RS00290	COG0540	Belongs to the ATCase OTCase family
AXH84_RS00295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXH84_RS00300	COG2951	lytic endotransglycosylase activity
AXH84_RS00305	COG1477	protein flavinylation
AXH84_RS00310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXH84_RS00315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXH84_RS00325	COG0189	ligase activity
AXH84_RS00330	COG3328	transposase activity
AXH84_RS00335	COG0189	ligase activity
AXH84_RS00370	COG0779	Required for maturation of 30S ribosomal subunits
AXH84_RS00375	COG0195	Participates in both transcription termination and antitermination
AXH84_RS00380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXH84_RS00385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXH84_RS00390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXH84_RS00405	COG0151	Belongs to the GarS family
AXH84_RS00415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXH84_RS00435	COG2181	nitrate reductase activity
AXH84_RS00440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AXH84_RS00450	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AXH84_RS00470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXH84_RS00475	COG2823	Periplasmic or secreted lipoprotein
AXH84_RS00480	COG0792	nuclease activity
AXH84_RS00485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXH84_RS00495	COG0237	dephospho-CoA kinase activity
AXH84_RS00510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AXH84_RS00515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AXH84_RS00525	COG0126	phosphoglycerate kinase activity
AXH84_RS00540	COG0445	tRNA wobble uridine modification
AXH84_RS00545	COG0357	Ribosomal RNA small subunit methyltransferase G
AXH84_RS00570	COG0084	hydrolase, TatD family'
AXH84_RS00580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AXH84_RS00585	COG2171	N-acyltransferase activity
AXH84_RS00590	COG1121	(ABC) transporter
AXH84_RS00595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXH84_RS00595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXH84_RS00605	COG1401	restriction endodeoxyribonuclease activity
AXH84_RS00605	COG1401	restriction endodeoxyribonuclease activity
AXH84_RS00625	COG0018	arginyl-trna synthetase
AXH84_RS00630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AXH84_RS00640	COG1074	ATP-dependent DNA helicase activity
AXH84_RS00645	COG0352	thiamine-phosphate diphosphorylase activity
AXH84_RS00660	COG2046	Belongs to the sulfate adenylyltransferase family
AXH84_RS00685	COG1047	Peptidyl-prolyl cis-trans
AXH84_RS00700	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AXH84_RS00705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXH84_RS00710	COG1862	Preprotein translocase
AXH84_RS00715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXH84_RS00720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXH84_RS00730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXH84_RS00760	COG0285	dihydrofolate synthase activity
AXH84_RS00775	COG0708	Exodeoxyribonuclease III
AXH84_RS00780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXH84_RS00785	COG0513	Belongs to the DEAD box helicase family
AXH84_RS00795	COG0138	bifunctional purine biosynthesis protein purh
AXH84_RS00825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXH84_RS00830	COG1793	dna ligase
AXH84_RS00875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXH84_RS00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXH84_RS00885	COG1131	(ABC) transporter
AXH84_RS00890	COG0842	Transport permease protein
AXH84_RS00895	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AXH84_RS00900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AXH84_RS00915	COG0351	phosphomethylpyrimidine kinase
AXH84_RS00920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXH84_RS00925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXH84_RS00945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXH84_RS00965	COG0131	Imidazoleglycerol-phosphate dehydratase
AXH84_RS00970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXH84_RS00980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXH84_RS00985	COG2925	Exonuclease
AXH84_RS00990	COG1278	Cold shock
AXH84_RS01000	COG0513	Belongs to the DEAD box helicase family
AXH84_RS01015	COG3278	Belongs to the heme-copper respiratory oxidase family
AXH84_RS01025	COG2010	Cytochrome c
AXH84_RS01045	COG3223	Belongs to the PsiE family
AXH84_RS01055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AXH84_RS01060	COG0084	hydrolase, TatD family'
AXH84_RS01065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXH84_RS01070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXH84_RS01080	COG0406	alpha-ribazole phosphatase activity
AXH84_RS01085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXH84_RS01090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AXH84_RS01100	COG0512	Glutamine amidotransferase of anthranilate synthase
AXH84_RS01105	COG2226	methyltransferase
AXH84_RS01110	COG3161	chorismate lyase activity
AXH84_RS01145	COG2204	response regulator
AXH84_RS01160	COG0375	protein maturation
AXH84_RS01165	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AXH84_RS01170	COG1773	rubredoxin
AXH84_RS01180	COG1773	rubredoxin
AXH84_RS01215	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AXH84_RS01235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AXH84_RS01240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AXH84_RS01250	COG0288	reversible hydration of carbon dioxide
AXH84_RS01265	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AXH84_RS01275	COG3328	transposase activity
AXH84_RS01295	COG0045	succinate-CoA ligase (ADP-forming) activity
AXH84_RS01310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXH84_RS01315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AXH84_RS01325	COG2983	Belongs to the UPF0260 family
AXH84_RS01335	COG0137	argininosuccinate synthase activity
AXH84_RS01350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXH84_RS01360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXH84_RS01365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AXH84_RS01370	COG0737	Belongs to the 5'-nucleotidase family
AXH84_RS01390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXH84_RS01395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXH84_RS01400	COG0049	tRNA binding
AXH84_RS01405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXH84_RS01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXH84_RS01415	COG0051	transcription antitermination factor activity, RNA binding
AXH84_RS01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXH84_RS01425	COG0088	Forms part of the polypeptide exit tunnel
AXH84_RS01430	COG0089	rRNA binding
AXH84_RS01435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXH84_RS01440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXH84_RS01445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXH84_RS01450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXH84_RS01455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXH84_RS01460	COG0255	Belongs to the universal ribosomal protein uL29 family
AXH84_RS01465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXH84_RS01470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXH84_RS01475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXH84_RS01480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXH84_RS01485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXH84_RS01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXH84_RS01495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXH84_RS01500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXH84_RS01505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXH84_RS01510	COG1841	ribosomal large subunit assembly
AXH84_RS01515	COG0200	Binds to the 23S rRNA
AXH84_RS01520	COG0201	protein transport
AXH84_RS01525	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AXH84_RS01530	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXH84_RS01535	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXH84_RS01540	COG0202	RNA polymerase activity
AXH84_RS01545	COG0203	ribosomal protein L17
AXH84_RS01550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXH84_RS01560	COG1610	YqeY-like protein
AXH84_RS01565	COG3328	transposase activity
AXH84_RS01595	COG1450	Type ii and iii secretion system protein
AXH84_RS01605	COG0730	response to heat
AXH84_RS01610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXH84_RS01630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AXH84_RS01650	COG0544	peptidyl-prolyl cis-trans isomerase activity
AXH84_RS01655	COG0740	serine-type endopeptidase activity
AXH84_RS01660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXH84_RS01665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXH84_RS01670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AXH84_RS01680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXH84_RS01685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AXH84_RS01690	COG3123	guanosine phosphorylase activity
AXH84_RS01695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH84_RS01735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AXH84_RS01745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXH84_RS01760	COG2210	Belongs to the sulfur carrier protein TusA family
AXH84_RS01765	COG0425	Belongs to the sulfur carrier protein TusA family
AXH84_RS01770	COG4783	chaperone-mediated protein folding
AXH84_RS01775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AXH84_RS01780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXH84_RS01785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXH84_RS01795	COG2132	Multicopper oxidase
AXH84_RS01810	COG2132	Multicopper oxidase
AXH84_RS01815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXH84_RS01820	COG0543	2 iron, 2 sulfur cluster binding
AXH84_RS01825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXH84_RS01840	COG0312	modulator of DNA gyrase
AXH84_RS01845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH84_RS01850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH84_RS01855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH84_RS01860	COG0649	NAD binding
AXH84_RS01865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AXH84_RS01870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AXH84_RS01885	COG1034	ATP synthesis coupled electron transport
AXH84_RS01890	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AXH84_RS01895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH84_RS01905	COG0713	ATP synthesis coupled electron transport
AXH84_RS01920	COG1007	ATP synthesis coupled electron transport
AXH84_RS01925	COG2226	methyltransferase
AXH84_RS01935	COG0500	methyltransferase
AXH84_RS01945	COG0233	cytoplasmic translational termination
AXH84_RS01950	COG0528	UMP kinase activity
AXH84_RS01955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXH84_RS01965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXH84_RS01970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXH84_RS01975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXH84_RS01990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXH84_RS01990	COG1648	precorrin-2 dehydrogenase activity
AXH84_RS02005	COG0560	Phosphoserine phosphatase
AXH84_RS02025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AXH84_RS02030	COG0336	Belongs to the RNA methyltransferase TrmD family
AXH84_RS02035	COG0347	Belongs to the P(II) protein family
AXH84_RS02040	COG0004	ammonium transporteR
AXH84_RS02045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXH84_RS02055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXH84_RS02060	COG0347	Belongs to the P(II) protein family
AXH84_RS02065	COG0004	ammonium transporteR
AXH84_RS02070	COG3707	response regulator
AXH84_RS02080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXH84_RS02085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXH84_RS02090	COG0140	phosphoribosyl-ATP diphosphatase activity
AXH84_RS02095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXH84_RS02115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AXH84_RS02115	COG0678	peroxiredoxin activity
AXH84_RS02120	COG0583	DNA-binding transcription factor activity
AXH84_RS02125	COG3023	N-Acetylmuramoyl-L-alanine amidase
AXH84_RS02130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AXH84_RS02135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXH84_RS02140	COG1560	Kdo2-lipid A biosynthetic process
AXH84_RS02145	COG0358	DNA primase activity
AXH84_RS02170	COG0275	rRNA processing
AXH84_RS02175	COG2001	Belongs to the MraZ family
AXH84_RS02185	COG0281	malic enzyme
AXH84_RS02205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXH84_RS02225	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AXH84_RS02230	COG0081	regulation of translation
AXH84_RS02235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AXH84_RS02240	COG0222	ribosome binding
AXH84_RS02245	COG0085	RNA polymerase activity
AXH84_RS02250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXH84_RS02275	COG3258	Cytochrome c
AXH84_RS02285	COG0587	DNA-directed DNA polymerase activity
AXH84_RS02295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXH84_RS02300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXH84_RS02300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXH84_RS02305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXH84_RS02310	COG2137	regulation of response to DNA damage stimulus
AXH84_RS02315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXH84_RS02355	COG0500	methyltransferase
AXH84_RS02375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXH84_RS02385	COG0076	glutamate decarboxylase activity
AXH84_RS02400	COG2918	glutathione biosynthetic process
AXH84_RS02400	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXH84_RS02400	COG0189	ligase activity
AXH84_RS02420	COG1595	DNA-templated transcription, initiation
AXH84_RS02435	COG3220	belongs to the UPF0276 family
AXH84_RS02450	COG0069	glutamate synthase activity
AXH84_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
AXH84_RS02490	COG1132	(ABC) transporter
AXH84_RS02495	COG0504	CTP synthase activity
AXH84_RS02505	COG1160	GTP binding
AXH84_RS02510	COG2976	Protein conserved in bacteria
AXH84_RS02515	COG0124	histidyl-tRNA synthetase
AXH84_RS02530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AXH84_RS02535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXH84_RS02540	COG0305	Participates in initiation and elongation during chromosome replication
AXH84_RS02545	COG0359	binds to the 23S rRNA
AXH84_RS02550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXH84_RS02555	COG0360	Binds together with S18 to 16S ribosomal RNA
AXH84_RS02560	COG2003	Belongs to the UPF0758 family
AXH84_RS02565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXH84_RS02570	COG1214	PFAM Peptidase M22, glycoprotease
AXH84_RS02580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AXH84_RS02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXH84_RS02590	COG0776	regulation of translation
AXH84_RS02605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXH84_RS02620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXH84_RS02645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXH84_RS02650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXH84_RS02655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXH84_RS02660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXH84_RS02670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXH84_RS02675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXH84_RS02675	COG0072	phenylalanine-tRNA ligase activity
AXH84_RS02680	COG0776	regulation of translation
AXH84_RS02690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AXH84_RS02705	COG0525	valine-tRNA ligase activity
AXH84_RS02710	COG2827	Endonuclease containing a URI domain
AXH84_RS02725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXH84_RS02730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXH84_RS02745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AXH84_RS02760	COG1686	Belongs to the peptidase S11 family
AXH84_RS02765	COG2951	lytic endotransglycosylase activity
AXH84_RS02770	COG0772	Belongs to the SEDS family
AXH84_RS02775	COG3737	Protein of unknown function (DUF498/DUF598)
AXH84_RS02810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXH84_RS02815	COG0259	pyridoxamine-phosphate oxidase activity
AXH84_RS02820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXH84_RS02825	COG1530	ribonuclease E activity
AXH84_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
AXH84_RS02840	COG0308	aminopeptidase N
AXH84_RS02845	COG1546	Belongs to the CinA family
AXH84_RS02845	COG1058	Belongs to the CinA family
AXH84_RS02870	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AXH84_RS02875	COG0028	Belongs to the TPP enzyme family
AXH84_RS02885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXH84_RS02890	COG1183	phosphatidylcholine synthase activity
AXH84_RS02895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXH84_RS02905	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AXH84_RS02910	COG5265	(ABC) transporter
AXH84_RS02915	COG0343	queuine tRNA-ribosyltransferase activity
AXH84_RS02925	COG0768	penicillin binding
AXH84_RS02940	COG1077	Cell shape determining protein MreB Mrl
AXH84_RS02945	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AXH84_RS02945	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AXH84_RS02955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXH84_RS02960	COG1376	ErfK ybiS ycfS ynhG family protein
AXH84_RS02975	COG1472	Belongs to the glycosyl hydrolase 3 family
AXH84_RS02990	COG0210	DNA helicase
AXH84_RS03000	COG1509	lysine 2,3-aminomutase activity
AXH84_RS03005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXH84_RS03010	COG1393	Belongs to the ArsC family
AXH84_RS03020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AXH84_RS03030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AXH84_RS03050	COG4974	Belongs to the 'phage' integrase family
AXH84_RS03065	COG1396	sequence-specific DNA binding
AXH84_RS03095	COG0270	DNA (cytosine-5-)-methyltransferase activity
AXH84_RS03125	COG0740	serine-type endopeptidase activity
AXH84_RS03230	COG4695	Portal protein
AXH84_RS03275	COG0564	pseudouridine synthase activity
AXH84_RS03280	COG1496	oxidoreductase activity
AXH84_RS03295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AXH84_RS03305	COG0354	folic acid binding
AXH84_RS03310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AXH84_RS03315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AXH84_RS03320	COG0180	Tryptophanyl-tRNA synthetase
AXH84_RS03325	COG1187	pseudouridine synthase activity
AXH84_RS03330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXH84_RS03335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AXH84_RS03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXH84_RS03350	COG0154	amidase activity
AXH84_RS03355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AXH84_RS03360	COG3645	SOS response
AXH84_RS03375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXH84_RS03380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXH84_RS03385	COG1994	Peptidase M50
AXH84_RS03390	COG0442	prolyl-tRNA aminoacylation
AXH84_RS03395	COG0688	phosphatidylethanolamine metabolic process
AXH84_RS03400	COG4536	flavin adenine dinucleotide binding
AXH84_RS03405	COG0148	phosphopyruvate hydratase activity
AXH84_RS03410	COG0484	heat shock protein binding
AXH84_RS03415	COG0443	Heat shock 70 kDa protein
AXH84_RS03425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AXH84_RS03435	COG0776	regulation of translation
AXH84_RS03525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AXH84_RS03555	COG3306	glycosyltransferase involved in LPS biosynthesis
AXH84_RS03570	COG0438	transferase activity, transferring glycosyl groups
AXH84_RS03575	COG1216	Glycosyl transferase, family 2
AXH84_RS03585	COG1215	transferase activity, transferring glycosyl groups
AXH84_RS03590	COG1215	transferase activity, transferring glycosyl groups
AXH84_RS03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXH84_RS03600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXH84_RS03605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXH84_RS03610	COG1596	polysaccharide export
AXH84_RS03615	COG0489	protein tyrosine kinase activity
AXH84_RS03615	COG3206	protein involved in exopolysaccharide biosynthesis
AXH84_RS03625	COG0436	Aminotransferase
AXH84_RS03630	COG0556	nucleotide-excision repair
AXH84_RS03635	COG0602	queuosine metabolic process
AXH84_RS03640	COG0071	Belongs to the small heat shock protein (HSP20) family
AXH84_RS03645	COG0659	secondary active sulfate transmembrane transporter activity
AXH84_RS03650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXH84_RS03670	COG0284	orotidine-5'-phosphate decarboxylase activity
AXH84_RS03695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AXH84_RS03715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AXH84_RS03720	COG0617	tRNA 3'-terminal CCA addition
AXH84_RS03725	COG0300	oxidoreductase activity
AXH84_RS03730	COG1722	exodeoxyribonuclease VII activity
AXH84_RS03735	COG0142	geranyltranstransferase activity
AXH84_RS03740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXH84_RS03745	COG0416	fatty acid biosynthetic process
AXH84_RS03750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXH84_RS03760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXH84_RS03775	COG0330	HflC and HflK could
AXH84_RS03780	COG0330	HflC and HflK could
AXH84_RS03785	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AXH84_RS03790	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXH84_RS03795	COG0557	exoribonuclease II activity
AXH84_RS03810	COG1519	Transferase
AXH84_RS03815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXH84_RS03820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AXH84_RS03825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXH84_RS03830	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXH84_RS03835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXH84_RS03840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXH84_RS03840	COG0316	Belongs to the HesB IscA family
AXH84_RS03845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AXH84_RS03850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXH84_RS03855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXH84_RS03875	COG0538	isocitrate dehydrogenase activity
AXH84_RS03915	COG4206	TonB-dependent receptor
AXH84_RS03920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AXH84_RS03925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXH84_RS03930	COG1605	Chorismate mutase
AXH84_RS03930	COG0077	Prephenate dehydratase
AXH84_RS03935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXH84_RS03940	COG0287	Prephenate dehydrogenase
AXH84_RS03945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXH84_RS03950	COG2920	part of a sulfur-relay system
AXH84_RS03960	COG1475	DNA binding
AXH84_RS03965	COG1192	Involved in chromosome partitioning
AXH84_RS03970	COG0793	Belongs to the peptidase S41A family
AXH84_RS04010	COG3177	Filamentation induced by cAMP protein fic
AXH84_RS04040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AXH84_RS04045	COG2824	Alkylphosphonate utilization operon protein PhnA
AXH84_RS04060	COG0571	ribonuclease III activity
AXH84_RS04065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXH84_RS04070	COG1381	Involved in DNA repair and RecF pathway recombination
AXH84_RS04075	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AXH84_RS04080	COG0736	holo-[acyl-carrier-protein] synthase activity
AXH84_RS04095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXH84_RS04100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXH84_RS04105	COG0481	GTPase activity
AXH84_RS04110	COG4137	Cytochrome C assembly protein
AXH84_RS04115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXH84_RS04125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXH84_RS04130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXH84_RS04140	COG0322	excinuclease ABC activity
AXH84_RS04145	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AXH84_RS04145	COG0546	phosphoglycolate phosphatase activity
AXH84_RS04150	COG0488	(ABC) transporter
AXH84_RS04160	COG0432	Pfam Uncharacterised protein family UPF0047
AXH84_RS04175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXH84_RS04190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXH84_RS04195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXH84_RS04215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH84_RS04240	COG2850	peptidyl-arginine hydroxylation
AXH84_RS04245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXH84_RS04250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXH84_RS04270	COG2194	sulfuric ester hydrolase activity
AXH84_RS04275	COG0795	lipopolysaccharide-transporting ATPase activity
AXH84_RS04300	COG1047	Peptidyl-prolyl cis-trans
AXH84_RS04315	COG1162	GTPase activity
AXH84_RS04325	COG0501	Belongs to the peptidase M48B family
AXH84_RS04345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXH84_RS04360	COG3422	double-strand break repair
AXH84_RS04405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXH84_RS04405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXH84_RS04410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXH84_RS04415	COG4597	amino acid ABC transporter
AXH84_RS04420	COG0765	amino acid transport
AXH84_RS04425	COG1126	abc transporter atp-binding protein
AXH84_RS04440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXH84_RS04445	COG0543	2 iron, 2 sulfur cluster binding
AXH84_RS04445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXH84_RS04455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXH84_RS04460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXH84_RS04470	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AXH84_RS04475	COG0709	Synthesizes selenophosphate from selenide and ATP
AXH84_RS04485	COG2304	oxidoreductase activity
AXH84_RS04505	COG0714	Associated with various cellular activities
AXH84_RS04515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXH84_RS04520	COG3864	Putative metallopeptidase domain
AXH84_RS04540	COG2921	Belongs to the UPF0250 family
AXH84_RS04545	COG0321	lipoyl(octanoyl) transferase activity
AXH84_RS04550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXH84_RS04555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXH84_RS04565	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AXH84_RS04570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXH84_RS04575	COG2967	ApaG domain
AXH84_RS04585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXH84_RS04600	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH84_RS04605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXH84_RS04610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH84_RS04615	COG0728	peptidoglycan biosynthetic process
AXH84_RS04620	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AXH84_RS04625	COG0194	GDP metabolic process
AXH84_RS04635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXH84_RS04640	COG0459	protein refolding
AXH84_RS04650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AXH84_RS04655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXH84_RS04660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXH84_RS04670	COG0339	signal peptide processing
AXH84_RS04680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXH84_RS04685	COG0489	protein tyrosine kinase activity
AXH84_RS04700	COG0443	Heat shock 70 kDa protein
AXH84_RS04710	COG0316	Belongs to the HesB IscA family
AXH84_RS04715	COG0822	iron-sulfur transferase activity
AXH84_RS04720	COG1104	cysteine desulfurase activity
AXH84_RS04735	COG1560	Kdo2-lipid A biosynthetic process
AXH84_RS04740	COG0037	tRNA processing
AXH84_RS04770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXH84_RS04775	COG2885	chlorophyll binding
AXH84_RS04780	COG0823	Involved in the tonB-independent uptake of proteins
AXH84_RS04790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXH84_RS04800	COG2814	Major facilitator Superfamily
AXH84_RS04805	COG0629	single-stranded DNA binding
AXH84_RS04810	COG0537	adenosine 5'-monophosphoramidase activity
AXH84_RS04820	COG0646	methionine synthase
AXH84_RS04820	COG1410	methionine synthase
AXH84_RS04825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXH84_RS04830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXH84_RS04860	COG0488	(ABC) transporter
AXH84_RS04865	COG0772	Belongs to the SEDS family
AXH84_RS04870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXH84_RS04875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXH84_RS04880	COG0174	glutamine synthetase
AXH84_RS04885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXH84_RS04885	COG0425	Belongs to the sulfur carrier protein TusA family
AXH84_RS04890	COG0408	coproporphyrinogen oxidase activity
AXH84_RS04900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AXH84_RS04905	COG0326	Molecular chaperone. Has ATPase activity
AXH84_RS04930	COG1028	Short-chain dehydrogenase reductase Sdr
AXH84_RS04935	COG1322	Protein conserved in bacteria
AXH84_RS04950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXH84_RS04955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AXH84_RS04955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXH84_RS04960	COG0129	dihydroxy-acid dehydratase activity
AXH84_RS04970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AXH84_RS04990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXH84_RS04995	COG1758	RNA polymerase activity
AXH84_RS05000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXH84_RS05025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AXH84_RS05035	COG1704	LemA family
AXH84_RS05040	COG0501	Belongs to the peptidase M48B family
AXH84_RS05055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXH84_RS05060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AXH84_RS05065	COG0217	transcriptional regulatory protein
AXH84_RS05080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AXH84_RS05085	COG2813	Specifically methylates the guanine in position
AXH84_RS05090	COG1054	Belongs to the UPF0176 family
AXH84_RS05095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXH84_RS05105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AXH84_RS05115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXH84_RS05125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AXH84_RS05140	COG2833	Protein of unknown function (DUF455)
AXH84_RS05170	COG0328	RNA-DNA hybrid ribonuclease activity
AXH84_RS05175	COG0367	asparagine synthase
AXH84_RS05180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXH84_RS05185	COG0066	3-isopropylmalate dehydratase activity
AXH84_RS05200	COG1217	gtp-binding protein TYPA
AXH84_RS05205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AXH84_RS05210	COG0142	geranyltranstransferase activity
AXH84_RS05215	COG1199	ATP-dependent helicase activity
AXH84_RS05230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXH84_RS05270	COG3328	transposase activity
AXH84_RS05280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXH84_RS05285	COG0569	domain protein
AXH84_RS05295	COG5000	phosphorelay sensor kinase activity
AXH84_RS05300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AXH84_RS05305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXH84_RS05310	COG0742	ribosomal rna small subunit methyltransferase
AXH84_RS05315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXH84_RS05320	COG0243	molybdopterin cofactor binding
AXH84_RS05325	COG2815	serine threonine protein kinase
AXH84_RS05325	COG0515	serine threonine protein kinase
AXH84_RS05330	COG2223	nitrite transmembrane transporter activity
AXH84_RS05335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXH84_RS05340	COG0314	molybdopterin synthase activity
AXH84_RS05345	COG0746	molybdenum cofactor guanylyltransferase activity
AXH84_RS05350	COG0303	'Molybdopterin
AXH84_RS05355	COG0315	cyclic pyranopterin monophosphate synthase activity
AXH84_RS05360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXH84_RS05365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AXH84_RS05370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXH84_RS05375	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXH84_RS05395	COG1850	ribulose-bisphosphate carboxylase activity
AXH84_RS05405	COG0788	formyltetrahydrofolate deformylase activity
AXH84_RS05410	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AXH84_RS05430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXH84_RS05435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXH84_RS05440	COG1393	Belongs to the ArsC family
AXH84_RS05450	COG0751	glycine-tRNA ligase activity
AXH84_RS05455	COG0850	regulation of cytokinetic process
AXH84_RS05475	COG0811	peptide transport
AXH84_RS05480	COG0824	Thioesterase
AXH84_RS05485	COG2255	four-way junction helicase activity
AXH84_RS05495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXH84_RS05500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXH84_RS05505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXH84_RS05510	COG0735	belongs to the Fur family
AXH84_RS05520	COG4133	protoheme IX ABC transporter activity
AXH84_RS05525	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXH84_RS05530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXH84_RS05535	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AXH84_RS05550	COG0752	glycyl-tRNA synthetase alpha subunit
AXH84_RS05555	COG1238	metal cluster binding
AXH84_RS05565	COG0668	transmembrane transport
AXH84_RS05570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH84_RS05585	COG2847	Copper chaperone PCu(A)C
AXH84_RS05600	COG1702	phosphate starvation-inducible protein PhoH
AXH84_RS05605	COG0482	sulfurtransferase activity
AXH84_RS05610	COG2915	High frequency lysogenization protein hflD homolog
AXH84_RS05615	COG0268	Binds directly to 16S ribosomal RNA
AXH84_RS05625	COG1570	exodeoxyribonuclease VII activity
AXH84_RS05630	COG0739	heme binding
AXH84_RS05645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AXH84_RS05650	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AXH84_RS05655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXH84_RS05660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AXH84_RS05665	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXH84_RS05680	COG0741	lytic transglycosylase activity
AXH84_RS05680	COG1388	LysM domain
AXH84_RS05685	COG0271	Belongs to the BolA IbaG family
AXH84_RS05690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXH84_RS05690	COG0543	2 iron, 2 sulfur cluster binding
AXH84_RS05695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXH84_RS05700	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AXH84_RS05710	COG3328	transposase activity
AXH84_RS05720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXH84_RS05730	COG0494	nUDIX hydrolase
AXH84_RS05740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXH84_RS05770	COG1981	membrane
AXH84_RS05775	COG0277	FAD linked oxidase domain protein
AXH84_RS05785	COG0612	Peptidase, M16
AXH84_RS05790	COG0612	Peptidase, M16
AXH84_RS05795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AXH84_RS05800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AXH84_RS05805	COG0552	protein localization to endoplasmic reticulum
AXH84_RS05835	COG0181	hydroxymethylbilane synthase activity
AXH84_RS05845	COG0165	Argininosuccinate lyase
AXH84_RS05850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXH84_RS05860	COG3038	cytochrome b561
AXH84_RS05865	COG0726	polysaccharide deacetylase
AXH84_RS05865	COG1649	PFAM Uncharacterised BCR, COG1649
AXH84_RS05870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXH84_RS05875	COG0542	response to heat
AXH84_RS05880	COG4660	Part of a membrane complex involved in electron transport
AXH84_RS05885	COG2890	protein-(glutamine-N5) methyltransferase activity
AXH84_RS05890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AXH84_RS05905	COG0247	lactate metabolic process
AXH84_RS05915	COG1204	response to ionizing radiation
AXH84_RS05930	COG0277	FAD linked oxidase domain protein
AXH84_RS05935	COG0277	FAD linked oxidase domain protein
AXH84_RS05950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AXH84_RS05955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AXH84_RS05960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXH84_RS05965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXH84_RS05975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AXH84_RS05980	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXH84_RS05985	COG2026	Addiction module toxin, RelE StbE family
AXH84_RS06000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AXH84_RS06005	COG1469	GTP cyclohydrolase I activity
AXH84_RS06015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXH84_RS06020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXH84_RS06020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AXH84_RS06025	COG0537	adenosine 5'-monophosphoramidase activity
AXH84_RS06030	COG1252	NADH dehydrogenase
AXH84_RS06040	COG0778	Nitroreductase
AXH84_RS06045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AXH84_RS06110	COG2081	HI0933 family
AXH84_RS06115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXH84_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH84_RS06130	COG2350	Protein conserved in bacteria
AXH84_RS06135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXH84_RS06140	COG0514	ATP-dependent DNA helicase (RecQ)
AXH84_RS06145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AXH84_RS06150	COG0134	indole-3-glycerol-phosphate synthase activity
AXH84_RS06170	COG2022	thiamine diphosphate biosynthetic process
AXH84_RS06185	COG2022	thiamine diphosphate biosynthetic process
AXH84_RS06190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXH84_RS06190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AXH84_RS06210	COG0156	8-amino-7-oxononanoate synthase activity
AXH84_RS06215	COG2267	carboxylic ester hydrolase activity
AXH84_RS06220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXH84_RS06240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXH84_RS06245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AXH84_RS06250	COG1663	tetraacyldisaccharide 4'-kinase activity
AXH84_RS06255	COG4591	ABC-type transport system involved in lipoprotein release permease component
AXH84_RS06275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXH84_RS06280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXH84_RS06295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AXH84_RS06300	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AXH84_RS06310	COG3630	sodium ion export across plasma membrane
AXH84_RS06320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXH84_RS06325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AXH84_RS06350	COG0802	atpase or kinase
AXH84_RS06360	COG1797	cobyrinic acid a,c-diamide synthase activity
AXH84_RS06395	COG2920	part of a sulfur-relay system
AXH84_RS06405	COG2923	Belongs to the DsrF TusC family
AXH84_RS06410	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AXH84_RS06415	COG2221	Nitrite and sulphite reductase 4Fe-4S
AXH84_RS06420	COG2221	Nitrite and sulphite reductase 4Fe-4S
AXH84_RS06425	COG0493	'glutamate synthase
AXH84_RS06430	COG0335	large ribosomal subunit rRNA binding
AXH84_RS06435	COG4974	Belongs to the 'phage' integrase family
AXH84_RS06440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXH84_RS06450	COG2853	Lipoprotein
AXH84_RS06480	COG0301	tRNA thio-modification
AXH84_RS06485	COG2264	protein methyltransferase activity
AXH84_RS06495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXH84_RS06500	COG0009	L-threonylcarbamoyladenylate synthase
AXH84_RS06505	COG0613	PHP domain protein
AXH84_RS06510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXH84_RS06530	COG0166	Belongs to the GPI family
AXH84_RS06535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXH84_RS06540	COG2194	sulfuric ester hydrolase activity
AXH84_RS06545	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AXH84_RS06550	COG0542	response to heat
AXH84_RS06555	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AXH84_RS06560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXH84_RS06560	COG0519	Catalyzes the synthesis of GMP from XMP
AXH84_RS06575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXH84_RS06580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXH84_RS06585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXH84_RS06590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXH84_RS06595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH84_RS06600	COG0557	exoribonuclease II activity
AXH84_RS06605	COG0509	glycine decarboxylation via glycine cleavage system
AXH84_RS06610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AXH84_RS06640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AXH84_RS06645	COG4659	FMN binding
AXH84_RS06650	COG4658	electron transport chain
AXH84_RS06655	COG4656	Part of a membrane complex involved in electron transport
AXH84_RS06660	COG2878	Part of a membrane complex involved in electron transport
AXH84_RS06665	COG4657	Part of a membrane complex involved in electron transport
AXH84_RS06685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH84_RS06690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXH84_RS06710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXH84_RS06715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXH84_RS06725	COG0513	Belongs to the DEAD box helicase family
AXH84_RS06740	COG0306	phosphate transporter
AXH84_RS06745	COG1392	Phosphate transport regulator
AXH84_RS06750	COG0825	malonyl-CoA metabolic process
AXH84_RS06755	COG0037	tRNA processing
AXH84_RS06760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXH84_RS06765	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXH84_RS06775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AXH84_RS06780	COG0546	phosphoglycolate phosphatase activity
AXH84_RS06800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXH84_RS06820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXH84_RS06840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXH84_RS06885	COG1131	(ABC) transporter
AXH84_RS06910	COG0006	proline dipeptidase activity
AXH84_RS06915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXH84_RS06920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AXH84_RS06925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AXH84_RS06935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXH84_RS06940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXH84_RS06955	COG0157	Belongs to the NadC ModD family
AXH84_RS06960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH84_RS06975	COG0019	diaminopimelate decarboxylase activity
AXH84_RS06980	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AXH84_RS06985	COG0494	nUDIX hydrolase
AXH84_RS07045	COG0640	Transcriptional regulator
AXH84_RS07050	COG0477	Major facilitator Superfamily
AXH84_RS07060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AXH84_RS07060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH84_RS07065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH84_RS07075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AXH84_RS07080	COG0473	3-isopropylmalate dehydrogenase activity
AXH84_RS07085	COG1773	rubredoxin
AXH84_RS07090	COG0450	alkyl hydroperoxide reductase
AXH84_RS07095	COG0215	cysteine-tRNA ligase activity
AXH84_RS07100	COG1011	Hydrolase
AXH84_RS07110	COG0205	6-phosphofructokinase activity
AXH84_RS07150	COG2197	response regulator
AXH84_RS07155	COG3850	Histidine kinase
AXH84_RS07160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AXH84_RS07165	COG2918	glutathione biosynthetic process
AXH84_RS07170	COG0352	thiamine-phosphate diphosphorylase activity
AXH84_RS07175	COG3328	transposase activity
AXH84_RS07235	COG0606	chelatase, subunit chli
AXH84_RS07255	COG0606	chelatase, subunit chli
AXH84_RS07275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXH84_RS07280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXH84_RS07285	COG1049	propionate catabolic process, 2-methylcitrate cycle
AXH84_RS07290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXH84_RS07295	COG0228	four-way junction DNA binding
AXH84_RS07300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXH84_RS07315	COG3328	transposase activity
AXH84_RS07325	COG0471	metal ion transport
AXH84_RS07325	COG0490	domain, Protein
AXH84_RS07330	COG0583	DNA-binding transcription factor activity
AXH84_RS07335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXH84_RS07345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AXH84_RS07350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AXH84_RS07350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AXH84_RS07360	COG1137	ATPase activity
AXH84_RS07365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXH84_RS07370	COG0606	chelatase, subunit chli
AXH84_RS07375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXH84_RS07380	COG2914	Belongs to the UPF0125 (RnfH) family
AXH84_RS07390	COG0312	modulator of DNA gyrase
AXH84_RS07395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXH84_RS07400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXH84_RS07410	COG1040	competence protein
AXH84_RS07415	COG3022	response to hydroperoxide
AXH84_RS07420	COG0070	glutamate synthase
AXH84_RS07420	COG0069	glutamate synthase activity
AXH84_RS07420	COG0067	glutamate synthase
AXH84_RS07425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXH84_RS07430	COG0052	Belongs to the universal ribosomal protein uS2 family
AXH84_RS07435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXH84_RS07440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AXH84_RS07445	COG0012	GTP binding
AXH84_RS07450	COG0193	aminoacyl-tRNA hydrolase activity
AXH84_RS07455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXH84_RS07460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AXH84_RS07470	COG2226	methyltransferase
AXH84_RS07480	COG3177	Filamentation induced by cAMP protein fic
AXH84_RS07485	COG0316	Belongs to the HesB IscA family
AXH84_RS07490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXH84_RS07495	COG0439	Biotin carboxylase
AXH84_RS07500	COG0511	ligase activity, forming carbon-carbon bonds
AXH84_RS07505	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AXH84_RS07510	COG4232	protein-disulfide reductase activity
AXH84_RS07520	COG0563	adenylate kinase activity
AXH84_RS07525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXH84_RS07530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXH84_RS07535	COG0497	DNA recombination
AXH84_RS07540	COG1714	RDD family
AXH84_RS07545	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXH84_RS07555	COG0356	it plays a direct role in the translocation of protons across the membrane
AXH84_RS07565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXH84_RS07570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXH84_RS07575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXH84_RS07580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXH84_RS07585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXH84_RS07590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXH84_RS07600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AXH84_RS07605	COG3023	N-Acetylmuramoyl-L-alanine amidase
AXH84_RS07625	COG0706	membrane insertase activity
AXH84_RS07630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AXH84_RS07635	COG0594	ribonuclease P activity
AXH84_RS07640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AXH84_RS07645	COG0758	DNA mediated transformation
AXH84_RS07650	COG2922	Belongs to the Smg family
AXH84_RS07685	COG0135	phosphoribosylanthranilate isomerase activity
AXH84_RS07690	COG0133	tryptophan synthase activity
AXH84_RS07695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXH84_RS07700	COG0254	rRNA binding
AXH84_RS07705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXH84_RS07720	COG0159	tryptophan synthase activity
AXH84_RS07725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXH84_RS07730	COG1047	Peptidyl-prolyl cis-trans
AXH84_RS07735	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AXH84_RS07740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXH84_RS07750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXH84_RS07755	COG0424	maF-like protein
AXH84_RS07760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXH84_RS07775	COG0149	triose-phosphate isomerase activity