locus-tag	class	description
NAREPO1_RS00010	COG0187	DNA topoisomerase II activity
NAREPO1_RS00015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NAREPO1_RS00020	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NAREPO1_RS00025	COG0539	negative regulation of cytoplasmic translation
NAREPO1_RS00030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NAREPO1_RS00035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NAREPO1_RS00040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NAREPO1_RS00045	COG0312	modulator of DNA gyrase
NAREPO1_RS00050	COG0275	rRNA processing
NAREPO1_RS00055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NAREPO1_RS00060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NAREPO1_RS00065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NAREPO1_RS00075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NAREPO1_RS00085	COG0653	protein targeting
NAREPO1_RS00090	COG0668	transmembrane transport
NAREPO1_RS00095	COG0071	Belongs to the small heat shock protein (HSP20) family
NAREPO1_RS00120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NAREPO1_RS00140	COG0459	protein refolding
NAREPO1_RS00145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NAREPO1_RS00160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NAREPO1_RS00170	COG0037	tRNA processing
NAREPO1_RS00175	COG0442	prolyl-tRNA aminoacylation
NAREPO1_RS00180	COG0513	Belongs to the DEAD box helicase family
NAREPO1_RS00185	COG1185	polyribonucleotide nucleotidyltransferase activity
NAREPO1_RS00190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NAREPO1_RS00200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NAREPO1_RS00205	COG0195	Participates in both transcription termination and antitermination
NAREPO1_RS00205	COG2251	uridine kinase activity
NAREPO1_RS00220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NAREPO1_RS00225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NAREPO1_RS00230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NAREPO1_RS00235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NAREPO1_RS00240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NAREPO1_RS00245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NAREPO1_RS00250	COG0254	rRNA binding
NAREPO1_RS00255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NAREPO1_RS00260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NAREPO1_RS00265	COG0180	Tryptophanyl-tRNA synthetase
NAREPO1_RS00270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NAREPO1_RS00275	COG0688	phosphatidylethanolamine metabolic process
NAREPO1_RS00285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NAREPO1_RS00295	COG0330	HflC and HflK could
NAREPO1_RS00300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NAREPO1_RS00305	COG0360	Binds together with S18 to 16S ribosomal RNA
NAREPO1_RS00310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NAREPO1_RS00320	COG0670	Belongs to the BI1 family
NAREPO1_RS00325	COG0772	Belongs to the SEDS family
NAREPO1_RS00330	COG0768	penicillin binding
NAREPO1_RS00335	COG0799	negative regulation of ribosome biogenesis
NAREPO1_RS00345	COG0495	leucyl-tRNA aminoacylation
NAREPO1_RS00350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NAREPO1_RS00355	COG0215	cysteine-tRNA ligase activity
NAREPO1_RS00370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NAREPO1_RS00380	COG0450	alkyl hydroperoxide reductase
NAREPO1_RS00395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NAREPO1_RS00400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NAREPO1_RS00405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NAREPO1_RS00410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NAREPO1_RS00415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NAREPO1_RS00420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NAREPO1_RS00425	COG0525	valine-tRNA ligase activity
NAREPO1_RS00435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NAREPO1_RS00440	COG0358	DNA primase activity
NAREPO1_RS00445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NAREPO1_RS00450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NAREPO1_RS00455	COG0617	tRNA 3'-terminal CCA addition
NAREPO1_RS00470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NAREPO1_RS00480	COG0312	modulator of DNA gyrase
NAREPO1_RS00485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NAREPO1_RS00495	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NAREPO1_RS00510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NAREPO1_RS00535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NAREPO1_RS00545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NAREPO1_RS00550	COG0328	RNA-DNA hybrid ribonuclease activity
NAREPO1_RS00555	COG0018	arginyl-trna synthetase
NAREPO1_RS00565	COG0482	sulfurtransferase activity
NAREPO1_RS00570	COG0537	adenosine 5'-monophosphoramidase activity
NAREPO1_RS00580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NAREPO1_RS00585	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NAREPO1_RS00595	COG1530	ribonuclease E activity
NAREPO1_RS00605	COG0017	Asparaginyl-tRNA synthetase
NAREPO1_RS00610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NAREPO1_RS00615	COG0126	phosphoglycerate kinase activity
NAREPO1_RS00620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NAREPO1_RS00625	COG0741	lytic transglycosylase activity
NAREPO1_RS00630	COG0445	tRNA wobble uridine modification
NAREPO1_RS00635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NAREPO1_RS00640	COG0228	four-way junction DNA binding
NAREPO1_RS00650	COG0335	large ribosomal subunit rRNA binding
NAREPO1_RS00660	COG1605	Chorismate mutase
NAREPO1_RS00660	COG0287	Prephenate dehydrogenase
NAREPO1_RS00665	COG0564	pseudouridine synthase activity
NAREPO1_RS00675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NAREPO1_RS00680	COG0193	aminoacyl-tRNA hydrolase activity
NAREPO1_RS00685	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NAREPO1_RS00690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NAREPO1_RS00695	COG1988	membrane-bound metal-dependent
NAREPO1_RS00700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NAREPO1_RS00705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NAREPO1_RS00715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NAREPO1_RS00720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NAREPO1_RS00725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NAREPO1_RS00725	COG0072	phenylalanine-tRNA ligase activity
NAREPO1_RS00730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NAREPO1_RS00740	COG0242	peptide deformylase activity
NAREPO1_RS00745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NAREPO1_RS00750	COG0203	ribosomal protein L17
NAREPO1_RS00755	COG0202	RNA polymerase activity
NAREPO1_RS00760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NAREPO1_RS00765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NAREPO1_RS00770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NAREPO1_RS00780	COG0201	protein transport
NAREPO1_RS00785	COG0200	Binds to the 23S rRNA
NAREPO1_RS00790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NAREPO1_RS00795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NAREPO1_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NAREPO1_RS00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NAREPO1_RS00820	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NAREPO1_RS00825	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NAREPO1_RS00830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NAREPO1_RS00835	COG0255	Belongs to the universal ribosomal protein uL29 family
NAREPO1_RS00840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NAREPO1_RS00845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NAREPO1_RS00850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NAREPO1_RS00855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NAREPO1_RS00860	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NAREPO1_RS00875	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NAREPO1_RS00880	COG0051	transcription antitermination factor activity, RNA binding
NAREPO1_RS00885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NAREPO1_RS00890	COG0049	tRNA binding
NAREPO1_RS00895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NAREPO1_RS00900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NAREPO1_RS00905	COG0085	RNA polymerase activity
NAREPO1_RS00910	COG0222	ribosome binding
NAREPO1_RS00915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NAREPO1_RS00920	COG0081	regulation of translation
NAREPO1_RS00930	COG0250	Participates in transcription elongation, termination and antitermination
NAREPO1_RS00970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NAREPO1_RS00975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NAREPO1_RS00980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NAREPO1_RS00990	COG0484	heat shock protein binding
NAREPO1_RS00995	COG0443	Heat shock 70 kDa protein
NAREPO1_RS01000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NAREPO1_RS01005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NAREPO1_RS01015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NAREPO1_RS01025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NAREPO1_RS01030	COG1077	Cell shape determining protein MreB Mrl
NAREPO1_RS01040	COG0629	single-stranded DNA binding
NAREPO1_RS01045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NAREPO1_RS01050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
NAREPO1_RS01055	COG1181	Belongs to the D-alanine--D-alanine ligase family
NAREPO1_RS01060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NAREPO1_RS01085	COG0024	Methionine aminopeptidase
NAREPO1_RS01090	COG0052	Belongs to the universal ribosomal protein uS2 family
NAREPO1_RS01115	COG0587	DNA-directed DNA polymerase activity
NAREPO1_RS01120	COG1278	Cold shock
NAREPO1_RS01140	COG0124	histidyl-tRNA synthetase
NAREPO1_RS01145	COG0751	glycine-tRNA ligase activity
NAREPO1_RS01155	COG0739	heme binding
NAREPO1_RS01165	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NAREPO1_RS01170	COG0571	ribonuclease III activity
NAREPO1_RS01185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NAREPO1_RS01190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NAREPO1_RS01200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NAREPO1_RS01205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NAREPO1_RS01215	COG0594	ribonuclease P activity
NAREPO1_RS01220	COG0230	Belongs to the bacterial ribosomal protein bL34 family