locus-tag	class	description
EBS_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBS_RS00010	COG0592	DNA-directed DNA polymerase activity
EBS_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EBS_RS00020	COG0187	DNA topoisomerase II activity
EBS_RS00040	COG0751	glycine-tRNA ligase activity
EBS_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
EBS_RS00050	COG0482	sulfurtransferase activity
EBS_RS00110	COG0174	glutamine synthetase
EBS_RS00120	COG3852	Histidine kinase
EBS_RS00155	COG0167	dihydroorotate dehydrogenase activity
EBS_RS00160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EBS_RS00165	COG0019	diaminopimelate decarboxylase activity
EBS_RS00170	COG2890	protein-(glutamine-N5) methyltransferase activity
EBS_RS00175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EBS_RS00185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EBS_RS00195	COG3300	MHYT domain
EBS_RS00195	COG5001	Diguanylate cyclase
EBS_RS00205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EBS_RS00220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_RS00240	COG2226	methyltransferase
EBS_RS00250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EBS_RS00265	COG2861	carbohydrate metabolic process
EBS_RS00270	COG0793	Belongs to the peptidase S41A family
EBS_RS00275	COG4942	peptidase
EBS_RS00280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EBS_RS00290	COG1054	Belongs to the UPF0176 family
EBS_RS00295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EBS_RS00300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EBS_RS00340	COG0339	signal peptide processing
EBS_RS00350	COG1704	LemA family
EBS_RS00355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EBS_RS00375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EBS_RS00395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EBS_RS00405	COG1715	Restriction endonuclease
EBS_RS00450	COG0745	RESPONSE REGULATOR receiver
EBS_RS00450	COG2972	Histidine kinase
EBS_RS00455	COG0165	Argininosuccinate lyase
EBS_RS00480	COG3072	Adenylate cyclase
EBS_RS00485	COG4520	surface antigen
EBS_RS00490	COG0400	carboxylic ester hydrolase activity
EBS_RS00495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EBS_RS00505	COG2959	enzyme of heme biosynthesis
EBS_RS00510	COG1587	Uroporphyrinogen-III synthase
EBS_RS00515	COG0181	hydroxymethylbilane synthase activity
EBS_RS00540	COG0009	L-threonylcarbamoyladenylate synthase
EBS_RS00550	COG2922	Belongs to the Smg family
EBS_RS00555	COG0758	DNA mediated transformation
EBS_RS00565	COG0242	peptide deformylase activity
EBS_RS00570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EBS_RS00585	COG5000	phosphorelay sensor kinase activity
EBS_RS00590	COG2204	response regulator
EBS_RS00595	COG0569	domain protein
EBS_RS00600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EBS_RS00605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EBS_RS00620	COG0205	6-phosphofructokinase activity
EBS_RS00640	COG0514	ATP-dependent DNA helicase (RecQ)
EBS_RS00665	COG0513	Belongs to the DEAD box helicase family
EBS_RS00675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EBS_RS00680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EBS_RS00700	COG2824	Alkylphosphonate utilization operon protein PhnA
EBS_RS00705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EBS_RS00710	COG0321	lipoyl(octanoyl) transferase activity
EBS_RS00715	COG2921	Belongs to the UPF0250 family
EBS_RS00720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBS_RS00725	COG1686	Belongs to the peptidase S11 family
EBS_RS00735	COG2951	lytic endotransglycosylase activity
EBS_RS00740	COG0772	Belongs to the SEDS family
EBS_RS00745	COG0768	penicillin binding
EBS_RS00750	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EBS_RS00755	COG1792	Involved in formation and maintenance of cell shape
EBS_RS00760	COG1077	Cell shape determining protein MreB Mrl
EBS_RS00765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBS_RS00770	COG0154	amidase activity
EBS_RS00775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EBS_RS00780	COG3706	GGDEF domain
EBS_RS00785	COG2813	Specifically methylates the guanine in position
EBS_RS00805	COG2890	protein-(glutamine-N5) methyltransferase activity
EBS_RS00810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EBS_RS00815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EBS_RS00830	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EBS_RS00840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EBS_RS00845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EBS_RS00850	COG0193	aminoacyl-tRNA hydrolase activity
EBS_RS00855	COG2409	Drug exporters of the RND superfamily
EBS_RS00895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EBS_RS00905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EBS_RS00915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EBS_RS00920	COG0081	regulation of translation
EBS_RS00925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EBS_RS00930	COG0222	ribosome binding
EBS_RS00935	COG0085	RNA polymerase activity
EBS_RS00940	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EBS_RS00945	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EBS_RS00950	COG0049	tRNA binding
EBS_RS00955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EBS_RS00960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EBS_RS00965	COG0051	transcription antitermination factor activity, RNA binding
EBS_RS00970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EBS_RS00975	COG0088	Forms part of the polypeptide exit tunnel
EBS_RS00980	COG0089	rRNA binding
EBS_RS00985	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EBS_RS00990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EBS_RS00995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EBS_RS01000	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EBS_RS01005	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EBS_RS01010	COG0255	Belongs to the universal ribosomal protein uL29 family
EBS_RS01015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EBS_RS01020	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EBS_RS01025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EBS_RS01030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EBS_RS01035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EBS_RS01040	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EBS_RS01045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EBS_RS01050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EBS_RS01055	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EBS_RS01065	COG0200	Binds to the 23S rRNA
EBS_RS01070	COG0201	protein transport
EBS_RS01075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EBS_RS01080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EBS_RS01085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EBS_RS01090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EBS_RS01095	COG0202	RNA polymerase activity
EBS_RS01100	COG0203	ribosomal protein L17
EBS_RS01115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EBS_RS01120	COG0432	Pfam Uncharacterised protein family UPF0047
EBS_RS01135	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EBS_RS01140	COG4535	Mg2 and Co2 transporter CorC
EBS_RS01145	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EBS_RS01150	COG1702	phosphate starvation-inducible protein PhoH
EBS_RS01155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBS_RS01165	COG0306	phosphate transporter
EBS_RS01185	COG2814	Major facilitator Superfamily
EBS_RS01195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EBS_RS01200	COG3161	chorismate lyase activity
EBS_RS01205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EBS_RS01220	COG1040	competence protein
EBS_RS01230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EBS_RS01235	COG0156	8-amino-7-oxononanoate synthase activity
EBS_RS01240	COG0596	Alpha beta hydrolase
EBS_RS01245	COG2226	methyltransferase
EBS_RS01265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EBS_RS01270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EBS_RS01275	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EBS_RS01305	COG0109	protoheme IX farnesyltransferase activity
EBS_RS01310	COG3278	Belongs to the heme-copper respiratory oxidase family
EBS_RS01325	COG2010	Cytochrome c
EBS_RS01330	COG0348	domain, Protein
EBS_RS01345	COG0784	Response regulator, receiver
EBS_RS01345	COG2205	protein histidine kinase activity
EBS_RS01360	COG1538	Outer membrane efflux protein
EBS_RS01395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBS_RS01410	COG2177	Part of the ABC transporter FtsEX involved in
EBS_RS01415	COG2884	Cell division ATP-binding protein ftsE
EBS_RS01420	COG0552	protein localization to endoplasmic reticulum
EBS_RS01425	COG0612	Peptidase, M16
EBS_RS01430	COG0612	Peptidase, M16
EBS_RS01435	COG0742	ribosomal rna small subunit methyltransferase
EBS_RS01440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EBS_RS01445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EBS_RS01480	COG1131	(ABC) transporter
EBS_RS01490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EBS_RS01500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EBS_RS01505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EBS_RS01510	COG0475	glutathione-regulated potassium exporter activity
EBS_RS01515	COG2003	Belongs to the UPF0758 family
EBS_RS01520	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EBS_RS01525	COG0756	dUTP diphosphatase activity
EBS_RS01535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBS_RS01540	COG1309	transcriptional regulator
EBS_RS01555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EBS_RS01560	COG0708	Exodeoxyribonuclease III
EBS_RS01585	COG1872	DUF167
EBS_RS01615	COG0543	2 iron, 2 sulfur cluster binding
EBS_RS01630	COG2020	methyltransferase activity
EBS_RS01635	COG0521	Mo-molybdopterin cofactor biosynthetic process
EBS_RS01640	COG0303	'Molybdopterin
EBS_RS01645	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EBS_RS01650	COG0314	molybdopterin synthase activity
EBS_RS01680	COG0789	Transcriptional regulator
EBS_RS01685	COG0501	Belongs to the peptidase M48B family
EBS_RS01690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EBS_RS01690	COG0678	peroxiredoxin activity
EBS_RS01705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBS_RS01720	COG3005	denitrification pathway
EBS_RS01745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_RS01750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS01765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS01775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EBS_RS01780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EBS_RS01790	COG4133	protoheme IX ABC transporter activity
EBS_RS01795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_RS01820	COG0512	Glutamine amidotransferase of anthranilate synthase
EBS_RS01825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EBS_RS01830	COG0134	indole-3-glycerol-phosphate synthase activity
EBS_RS01840	COG1765	OsmC-like protein
EBS_RS01845	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EBS_RS01850	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EBS_RS01855	COG2967	ApaG domain
EBS_RS01875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EBS_RS01880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_RS01885	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EBS_RS01890	COG3178	'Phosphotransferase
EBS_RS01905	COG3154	lipid carrier protein
EBS_RS01915	COG0826	peptidase U32
EBS_RS01920	COG1242	4 iron, 4 sulfur cluster binding
EBS_RS01925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EBS_RS01925	COG1328	CTP reductase activity
EBS_RS01945	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EBS_RS01980	COG0646	methionine synthase
EBS_RS01980	COG1410	methionine synthase
EBS_RS01985	COG0704	Plays a role in the regulation of phosphate uptake
EBS_RS02000	COG1643	Atp-dependent helicase
EBS_RS02020	COG0019	diaminopimelate decarboxylase activity
EBS_RS02025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EBS_RS02065	COG2217	Heavy metal translocating P-type atpase
EBS_RS02090	COG0471	metal ion transport
EBS_RS02090	COG3273	potassium ion transport
EBS_RS02095	COG1444	tRNA N-acetyltransferase activity
EBS_RS02100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EBS_RS02105	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EBS_RS02125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EBS_RS02140	COG1260	myo-inositol-1-phosphate synthase
EBS_RS02145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EBS_RS02155	COG3954	Phosphoribulokinase
EBS_RS02160	COG0277	FAD linked oxidase domain protein
EBS_RS02170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EBS_RS02175	COG0792	nuclease activity
EBS_RS02185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EBS_RS02190	COG2001	Belongs to the MraZ family
EBS_RS02195	COG0275	rRNA processing
EBS_RS02210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EBS_RS02215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EBS_RS02220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBS_RS02225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EBS_RS02230	COG0772	Belongs to the SEDS family
EBS_RS02235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EBS_RS02240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBS_RS02245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EBS_RS02250	COG1181	Belongs to the D-alanine--D-alanine ligase family
EBS_RS02255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EBS_RS02265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EBS_RS02270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EBS_RS02280	COG0739	heme binding
EBS_RS02285	COG0653	protein targeting
EBS_RS02290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EBS_RS02305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EBS_RS02310	COG0237	dephospho-CoA kinase activity
EBS_RS02340	COG0542	response to heat
EBS_RS02345	COG0242	peptide deformylase activity
EBS_RS02355	COG1496	oxidoreductase activity
EBS_RS02360	COG0564	pseudouridine synthase activity
EBS_RS02380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EBS_RS02385	COG0045	succinate-CoA ligase (ADP-forming) activity
EBS_RS02440	COG1120	ATPase activity
EBS_RS02445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EBS_RS02455	COG0494	nUDIX hydrolase
EBS_RS02460	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EBS_RS02465	COG0069	glutamate synthase activity
EBS_RS02485	COG1714	RDD family
EBS_RS02530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EBS_RS02540	COG4660	Part of a membrane complex involved in electron transport
EBS_RS02545	COG4659	FMN binding
EBS_RS02550	COG4658	electron transport chain
EBS_RS02560	COG2878	Part of a membrane complex involved in electron transport
EBS_RS02565	COG4657	Part of a membrane complex involved in electron transport
EBS_RS02580	COG1858	cytochrome C peroxidase
EBS_RS02590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBS_RS02590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EBS_RS02595	COG0489	protein tyrosine kinase activity
EBS_RS02605	COG3842	ATPase activity
EBS_RS02610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EBS_RS02615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EBS_RS02630	COG0367	asparagine synthase
EBS_RS02635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EBS_RS02645	COG2853	Lipoprotein
EBS_RS02675	COG1490	D-aminoacyl-tRNA deacylase activity
EBS_RS02680	COG0131	Imidazoleglycerol-phosphate dehydratase
EBS_RS02685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EBS_RS02690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EBS_RS02695	COG0107	imidazoleglycerol-phosphate synthase activity
EBS_RS02700	COG0140	phosphoribosyl-ATP diphosphatase activity
EBS_RS02705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBS_RS02710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EBS_RS02720	COG1331	Highly conserved protein containing a thioredoxin domain
EBS_RS02730	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
EBS_RS02745	COG0358	DNA primase activity
EBS_RS02750	COG1610	YqeY-like protein
EBS_RS02755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EBS_RS02765	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EBS_RS02780	COG1028	Short-chain dehydrogenase reductase Sdr
EBS_RS02820	COG0739	heme binding
EBS_RS02820	COG1196	nuclear chromosome segregation
EBS_RS02820	COG0741	lytic transglycosylase activity
EBS_RS02825	COG0483	inositol monophosphate 1-phosphatase activity
EBS_RS02830	COG0247	lactate metabolic process
EBS_RS02845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EBS_RS02855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EBS_RS02865	COG0004	ammonium transporteR
EBS_RS02875	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBS_RS02880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_RS02885	COG0596	Alpha beta hydrolase
EBS_RS02900	COG0142	geranyltranstransferase activity
EBS_RS02905	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EBS_RS02910	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EBS_RS02915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EBS_RS02920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EBS_RS02930	COG0840	transmembrane signaling receptor activity
EBS_RS02935	COG0268	Binds directly to 16S ribosomal RNA
EBS_RS02940	COG0728	peptidoglycan biosynthetic process
EBS_RS02945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EBS_RS02950	COG0196	riboflavin kinase activity
EBS_RS02955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EBS_RS02960	COG0529	Catalyzes the synthesis of activated sulfate
EBS_RS02965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EBS_RS02970	COG3023	N-Acetylmuramoyl-L-alanine amidase
EBS_RS03010	COG1047	Peptidyl-prolyl cis-trans
EBS_RS03020	COG0271	Belongs to the BolA IbaG family
EBS_RS03030	COG0508	dehydrogenase complex catalyzes the overall conversion of
EBS_RS03035	COG0567	Dehydrogenase, E1 component
EBS_RS03100	COG0784	Response regulator, receiver
EBS_RS03100	COG0835	chemotaxis
EBS_RS03105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EBS_RS03110	COG1815	bacterial-type flagellum-dependent cell motility
EBS_RS03115	COG1558	bacterial-type flagellum-dependent cell motility
EBS_RS03120	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EBS_RS03130	COG4786	Flagellar basal body rod
EBS_RS03140	COG4786	Flagellar basal body rod
EBS_RS03145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EBS_RS03155	COG3951	Flagellar rod assembly protein muramidase FlgJ
EBS_RS03155	COG1705	Flagellar rod assembly protein muramidase FlgJ
EBS_RS03160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EBS_RS03210	COG2827	Endonuclease containing a URI domain
EBS_RS03240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EBS_RS03255	COG0515	serine threonine protein kinase
EBS_RS03255	COG2815	serine threonine protein kinase
EBS_RS03260	COG2920	part of a sulfur-relay system
EBS_RS03265	COG2223	nitrite transmembrane transporter activity
EBS_RS03270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EBS_RS03280	COG0243	molybdopterin cofactor binding
EBS_RS03285	COG0437	4 iron, 4 sulfur cluster binding
EBS_RS03290	COG0318	PFAM AMP-dependent synthetase and ligase
EBS_RS03300	COG1441	menaquinone biosynthetic process
EBS_RS03305	COG4263	nitrous-oxide reductase activity
EBS_RS03330	COG1575	Belongs to the MenA family. Type 1 subfamily
EBS_RS03335	COG0243	molybdopterin cofactor binding
EBS_RS03340	COG1763	Mo-molybdopterin cofactor biosynthetic process
EBS_RS03365	COG0659	secondary active sulfate transmembrane transporter activity
EBS_RS03370	COG1047	Peptidyl-prolyl cis-trans
EBS_RS03380	COG4206	TonB-dependent receptor
EBS_RS03415	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EBS_RS03420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EBS_RS03425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EBS_RS03460	COG0489	protein tyrosine kinase activity
EBS_RS03465	COG4464	protein tyrosine phosphatase activity
EBS_RS03480	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EBS_RS03535	COG0572	uridine kinase
EBS_RS03540	COG0735	belongs to the Fur family
EBS_RS03545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EBS_RS03550	COG1121	(ABC) transporter
EBS_RS03555	COG0803	Belongs to the bacterial solute-binding protein 9 family
EBS_RS03560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EBS_RS03565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EBS_RS03570	COG0659	secondary active sulfate transmembrane transporter activity
EBS_RS03575	COG1278	Cold shock
EBS_RS03580	COG0724	RNA recognition motif
EBS_RS03630	COG1850	ribulose-bisphosphate carboxylase activity
EBS_RS03660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EBS_RS03665	COG0537	adenosine 5'-monophosphoramidase activity
EBS_RS03680	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EBS_RS03685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EBS_RS03690	COG1393	Belongs to the ArsC family
EBS_RS03695	COG2171	N-acyltransferase activity
EBS_RS03700	COG0436	Aminotransferase
EBS_RS03715	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EBS_RS03720	COG0024	Methionine aminopeptidase
EBS_RS03725	COG0052	Belongs to the universal ribosomal protein uS2 family
EBS_RS03730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EBS_RS03735	COG0528	UMP kinase activity
EBS_RS03740	COG0233	cytoplasmic translational termination
EBS_RS03745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EBS_RS03750	COG0575	Belongs to the CDS family
EBS_RS03755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EBS_RS03760	COG0750	zinc metalloprotease
EBS_RS03775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_RS03780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBS_RS03785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_RS03790	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_RS03800	COG1355	regulation of microtubule-based process
EBS_RS03805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EBS_RS03820	COG0717	Belongs to the dCTP deaminase family
EBS_RS03825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EBS_RS03830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EBS_RS03845	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EBS_RS03850	COG0628	permease
EBS_RS03855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EBS_RS03870	COG1393	Belongs to the ArsC family
EBS_RS03885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS03905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EBS_RS03910	COG0583	DNA-binding transcription factor activity
EBS_RS03915	COG1592	Rubrerythrin
EBS_RS03930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EBS_RS03935	COG2205	protein histidine kinase activity
EBS_RS03945	COG0442	prolyl-tRNA aminoacylation
EBS_RS03960	COG0488	(ABC) transporter
EBS_RS03965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EBS_RS03990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EBS_RS03995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EBS_RS04000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBS_RS04000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EBS_RS04020	COG1309	transcriptional regulator
EBS_RS04025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBS_RS04035	COG1136	(ABC) transporter
EBS_RS04060	COG0142	geranyltranstransferase activity
EBS_RS04065	COG1722	exodeoxyribonuclease VII activity
EBS_RS04095	COG5001	Diguanylate cyclase
EBS_RS04095	COG5002	protein histidine kinase activity
EBS_RS04120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EBS_RS04125	COG0517	IMP dehydrogenase activity
EBS_RS04125	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EBS_RS04125	COG0617	tRNA 3'-terminal CCA addition
EBS_RS04145	COG1199	ATP-dependent helicase activity
EBS_RS04155	COG1214	PFAM Peptidase M22, glycoprotease
EBS_RS04160	COG0523	cobalamin synthesis protein
EBS_RS04175	COG2833	Protein of unknown function (DUF455)
EBS_RS04185	COG0688	phosphatidylethanolamine metabolic process
EBS_RS04190	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EBS_RS04235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EBS_RS04265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EBS_RS04270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EBS_RS04275	COG0308	aminopeptidase N
EBS_RS04280	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
EBS_RS04285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EBS_RS04300	COG5265	(ABC) transporter
EBS_RS04310	COG0617	tRNA 3'-terminal CCA addition
EBS_RS04315	COG3850	Histidine kinase
EBS_RS04320	COG2197	response regulator
EBS_RS04340	COG0215	cysteine-tRNA ligase activity
EBS_RS04355	COG1162	GTPase activity
EBS_RS04370	COG3706	GGDEF domain
EBS_RS04370	COG4251	negative regulation of phosphorylation
EBS_RS04370	COG5001	Diguanylate cyclase
EBS_RS04370	COG2203	Gaf domain
EBS_RS04375	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EBS_RS04385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EBS_RS04385	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EBS_RS04390	COG0802	atpase or kinase
EBS_RS04395	COG0860	N-Acetylmuramoyl-L-alanine amidase
EBS_RS04405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EBS_RS04410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EBS_RS04415	COG1923	regulation of RNA biosynthetic process
EBS_RS04420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EBS_RS04425	COG0330	HflC and HflK could
EBS_RS04430	COG0330	HflC and HflK could
EBS_RS04440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EBS_RS04445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EBS_RS04460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBS_RS04465	COG0071	Belongs to the small heat shock protein (HSP20) family
EBS_RS04475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EBS_RS04480	COG1940	carbohydrate kinase activity
EBS_RS04530	COG1509	lysine 2,3-aminomutase activity
EBS_RS04535	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EBS_RS04560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBS_RS04560	COG1648	precorrin-2 dehydrogenase activity
EBS_RS04565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBS_RS04570	COG0425	Belongs to the sulfur carrier protein TusA family
EBS_RS04575	COG2210	Belongs to the sulfur carrier protein TusA family
EBS_RS04585	COG0583	DNA-binding transcription factor activity
EBS_RS04605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_RS04620	COG0784	Response regulator, receiver
EBS_RS04620	COG2205	protein histidine kinase activity
EBS_RS04620	COG5002	protein histidine kinase activity
EBS_RS04625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EBS_RS04635	COG2716	regulation of RNA biosynthetic process
EBS_RS04660	COG1294	oxidase, subunit
EBS_RS04670	COG0488	(ABC) transporter
EBS_RS04695	COG0243	molybdopterin cofactor binding
EBS_RS04700	COG0437	4 iron, 4 sulfur cluster binding
EBS_RS04705	COG3302	dmso reductase anchor subunit
EBS_RS04725	COG0826	peptidase U32
EBS_RS04735	COG2983	Belongs to the UPF0260 family
EBS_RS04745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EBS_RS04750	COG0631	protein serine/threonine phosphatase activity
EBS_RS04765	COG0525	valine-tRNA ligase activity
EBS_RS04785	COG0737	Belongs to the 5'-nucleotidase family
EBS_RS04790	COG0247	lactate metabolic process
EBS_RS04795	COG0277	FAD linked oxidase domain protein
EBS_RS04800	COG0277	FAD linked oxidase domain protein
EBS_RS04805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EBS_RS04830	COG1414	Transcriptional regulator
EBS_RS04835	COG0513	Belongs to the DEAD box helicase family
EBS_RS04840	COG2814	Major facilitator Superfamily
EBS_RS04845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EBS_RS04850	COG3273	potassium ion transport
EBS_RS04850	COG0471	metal ion transport
EBS_RS04860	COG2920	part of a sulfur-relay system
EBS_RS04870	COG0564	pseudouridine synthase activity
EBS_RS04880	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EBS_RS04895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EBS_RS04915	COG0489	protein tyrosine kinase activity
EBS_RS04945	COG2132	Multicopper oxidase
EBS_RS04955	COG0297	glycogen (starch) synthase activity
EBS_RS04955	COG0438	transferase activity, transferring glycosyl groups
EBS_RS04960	COG0535	radical SAM domain protein
EBS_RS04975	COG3267	Type II secretory pathway component ExeA
EBS_RS04975	COG3409	Peptidoglycan-binding domain 1 protein
EBS_RS04990	COG1959	2 iron, 2 sulfur cluster binding
EBS_RS04995	COG1104	cysteine desulfurase activity
EBS_RS05000	COG0724	RNA recognition motif
EBS_RS05015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EBS_RS05025	COG0633	Ferredoxin
EBS_RS05040	COG0105	UTP biosynthetic process
EBS_RS05045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EBS_RS05055	COG1426	Protein conserved in bacteria
EBS_RS05060	COG0124	histidyl-tRNA synthetase
EBS_RS05065	COG2976	Protein conserved in bacteria
EBS_RS05075	COG1160	GTP binding
EBS_RS05090	COG2974	May be involved in recombination
EBS_RS05095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EBS_RS05110	COG1760	l-serine dehydratase
EBS_RS05115	COG0303	'Molybdopterin
EBS_RS05120	COG1763	Mo-molybdopterin cofactor biosynthetic process
EBS_RS05125	COG0746	molybdenum cofactor guanylyltransferase activity
EBS_RS05130	COG3842	ATPase activity
EBS_RS05135	COG4662	Binding-protein-dependent transport system inner membrane component
EBS_RS05155	COG2358	TRAP transporter, solute receptor (TAXI family
EBS_RS05170	COG1902	pentaerythritol trinitrate reductase activity
EBS_RS05175	COG2814	Major facilitator Superfamily
EBS_RS05210	COG0557	exoribonuclease II activity
EBS_RS05215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EBS_RS05220	COG0360	Binds together with S18 to 16S ribosomal RNA
EBS_RS05225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EBS_RS05235	COG0359	binds to the 23S rRNA
EBS_RS05245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EBS_RS05260	COG4536	flavin adenine dinucleotide binding
EBS_RS05270	COG3852	Histidine kinase
EBS_RS05320	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EBS_RS05325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EBS_RS05340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EBS_RS05340	COG0426	domain, Protein
EBS_RS05345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS05355	COG1959	2 iron, 2 sulfur cluster binding
EBS_RS05390	COG0318	PFAM AMP-dependent synthetase and ligase
EBS_RS05395	COG0398	Pfam SNARE associated Golgi protein
EBS_RS05415	COG2226	methyltransferase
EBS_RS05435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EBS_RS05440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EBS_RS05445	COG0077	Prephenate dehydratase
EBS_RS05445	COG1605	Chorismate mutase
EBS_RS05450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EBS_RS05455	COG0287	Prephenate dehydrogenase
EBS_RS05515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EBS_RS05520	COG0733	neurotransmitter:sodium symporter activity
EBS_RS05525	COG2867	negative regulation of translational initiation
EBS_RS05530	COG2914	Belongs to the UPF0125 (RnfH) family
EBS_RS05535	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EBS_RS05540	COG0735	belongs to the Fur family
EBS_RS05570	COG0497	DNA recombination
EBS_RS05575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EBS_RS05580	COG1420	regulation of RNA biosynthetic process
EBS_RS05585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EBS_RS05590	COG0443	Heat shock 70 kDa protein
EBS_RS05595	COG0484	heat shock protein binding
EBS_RS05600	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EBS_RS05625	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EBS_RS05630	COG0284	orotidine-5'-phosphate decarboxylase activity
EBS_RS05635	COG2046	Belongs to the sulfate adenylyltransferase family
EBS_RS05655	COG2850	peptidyl-arginine hydroxylation
EBS_RS05680	COG0482	sulfurtransferase activity
EBS_RS05690	COG0670	Belongs to the BI1 family
EBS_RS05735	COG2197	response regulator
EBS_RS05740	COG1573	uracil-dna glycosylase
EBS_RS05745	COG0322	excinuclease ABC activity
EBS_RS05805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EBS_RS05835	COG2346	COG2346, Truncated hemoglobins
EBS_RS05840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBS_RS05845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EBS_RS05850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EBS_RS05855	COG0436	Aminotransferase
EBS_RS05860	COG1230	cation diffusion facilitator family transporter
EBS_RS05865	COG0826	peptidase U32
EBS_RS05885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBS_RS05890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EBS_RS05905	COG0436	Aminotransferase
EBS_RS05915	COG0318	PFAM AMP-dependent synthetase and ligase
EBS_RS05930	COG2333	competence protein COMEC
EBS_RS05930	COG0658	competence protein
EBS_RS05935	COG0811	peptide transport
EBS_RS05940	COG0848	biopolymer transport protein
EBS_RS05945	COG1663	tetraacyldisaccharide 4'-kinase activity
EBS_RS05950	COG2835	tetraacyldisaccharide 4'-kinase activity
EBS_RS05955	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EBS_RS05965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EBS_RS05970	COG1530	ribonuclease E activity
EBS_RS05980	COG0546	phosphoglycolate phosphatase activity
EBS_RS06010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EBS_RS06040	COG3706	GGDEF domain
EBS_RS06040	COG5001	Diguanylate cyclase
EBS_RS06040	COG2203	Gaf domain
EBS_RS06040	COG4251	negative regulation of phosphorylation
EBS_RS06070	COG1472	Belongs to the glycosyl hydrolase 3 family
EBS_RS06095	COG0747	negative chemotaxis
EBS_RS06115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EBS_RS06130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EBS_RS06135	COG1381	Involved in DNA repair and RecF pathway recombination
EBS_RS06160	COG0481	GTPase activity
EBS_RS06170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EBS_RS06190	COG1595	DNA-templated transcription, initiation
EBS_RS06205	COG0084	hydrolase, TatD family'
EBS_RS06225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EBS_RS06230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EBS_RS06235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EBS_RS06240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EBS_RS06250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EBS_RS06255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EBS_RS06260	COG0416	fatty acid biosynthetic process
EBS_RS06265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EBS_RS06285	COG3630	sodium ion export across plasma membrane
EBS_RS06290	COG0424	maF-like protein
EBS_RS06295	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EBS_RS06305	COG1254	Belongs to the acylphosphatase family
EBS_RS06320	COG0583	DNA-binding transcription factor activity
EBS_RS06340	COG1286	toxin biosynthetic process
EBS_RS06360	COG0285	dihydrofolate synthase activity
EBS_RS06365	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EBS_RS06370	COG0159	tryptophan synthase activity
EBS_RS06375	COG0133	tryptophan synthase activity
EBS_RS06380	COG0135	phosphoribosylanthranilate isomerase activity
EBS_RS06385	COG0101	tRNA pseudouridine synthase activity
EBS_RS06400	COG0473	3-isopropylmalate dehydrogenase activity
EBS_RS06405	COG0066	3-isopropylmalate dehydratase activity
EBS_RS06410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EBS_RS06440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EBS_RS06470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EBS_RS06475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EBS_RS06480	COG0180	Tryptophanyl-tRNA synthetase
EBS_RS06485	COG1994	Peptidase M50
EBS_RS06490	COG0009	L-threonylcarbamoyladenylate synthase
EBS_RS06520	COG2917	probably involved in intracellular septation
EBS_RS06525	COG2350	Protein conserved in bacteria
EBS_RS06530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_RS06555	COG1238	metal cluster binding
EBS_RS06560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBS_RS06565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EBS_RS06585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EBS_RS06605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EBS_RS06615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EBS_RS06640	COG1968	undecaprenyl-diphosphatase activity
EBS_RS06660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_RS06670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EBS_RS06680	COG0500	methyltransferase
EBS_RS06715	COG4974	Belongs to the 'phage' integrase family
EBS_RS06745	COG0776	regulation of translation
EBS_RS06750	COG0072	phenylalanine-tRNA ligase activity
EBS_RS06755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EBS_RS06760	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EBS_RS06765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EBS_RS06770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EBS_RS06775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EBS_RS06780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBS_RS06805	COG2801	Transposase and inactivated derivatives
EBS_RS06820	COG0402	S-adenosylhomocysteine deaminase activity
EBS_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
EBS_RS06855	COG0463	Glycosyl transferase, family 2
EBS_RS06860	COG1538	Outer membrane efflux protein
EBS_RS06865	COG0739	heme binding
EBS_RS06875	COG0429	hydrolase of the alpha beta-hydrolase fold
EBS_RS06905	COG3012	SEC-C Motif Domain Protein
EBS_RS06915	COG1643	Atp-dependent helicase
EBS_RS06940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EBS_RS06945	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EBS_RS06950	COG0148	phosphopyruvate hydratase activity
EBS_RS06955	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EBS_RS06960	COG0504	CTP synthase activity
EBS_RS06970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_RS06975	COG3278	Belongs to the heme-copper respiratory oxidase family
EBS_RS06990	COG2010	Cytochrome c
EBS_RS07015	COG0328	RNA-DNA hybrid ribonuclease activity
EBS_RS07020	COG2226	methyltransferase
EBS_RS07035	COG4172	Belongs to the ABC transporter superfamily
EBS_RS07045	COG0601	transmembrane transport
EBS_RS07050	COG4166	transmembrane transport
EBS_RS07065	COG1215	transferase activity, transferring glycosyl groups
EBS_RS07085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EBS_RS07090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EBS_RS07095	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EBS_RS07125	COG0511	ligase activity, forming carbon-carbon bonds
EBS_RS07125	COG5016	pyruvate
EBS_RS07130	COG0439	Biotin carboxylase
EBS_RS07135	COG0585	pseudouridine synthase activity
EBS_RS07140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EBS_RS07145	COG0084	hydrolase, TatD family'
EBS_RS07165	COG0647	UMP catabolic process
EBS_RS07225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EBS_RS07245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EBS_RS07250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EBS_RS07255	COG0740	serine-type endopeptidase activity
EBS_RS07260	COG0544	peptidyl-prolyl cis-trans isomerase activity
EBS_RS07275	COG0776	regulation of translation
EBS_RS07290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EBS_RS07310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EBS_RS07310	COG0519	Catalyzes the synthesis of GMP from XMP
EBS_RS07320	COG0563	adenylate kinase activity
EBS_RS07325	COG0563	adenylate kinase activity
EBS_RS07340	COG0583	DNA-binding transcription factor activity
EBS_RS07345	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EBS_RS07375	COG0326	Molecular chaperone. Has ATPase activity
EBS_RS07395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EBS_RS07400	COG0527	aspartate kinase activity
EBS_RS07405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EBS_RS07430	COG0419	ATPase involved in DNA repair
EBS_RS07440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EBS_RS07445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS07460	COG0557	exoribonuclease II activity
EBS_RS07480	COG0668	transmembrane transport
EBS_RS07485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EBS_RS07490	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EBS_RS07500	COG0617	tRNA 3'-terminal CCA addition
EBS_RS07530	COG2995	paraquat-inducible protein a
EBS_RS07535	COG0037	tRNA processing
EBS_RS07540	COG0825	malonyl-CoA metabolic process
EBS_RS07545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EBS_RS07565	COG1074	ATP-dependent DNA helicase activity
EBS_RS07570	COG0259	pyridoxamine-phosphate oxidase activity
EBS_RS07580	COG0259	pyridoxamine-phosphate oxidase activity
EBS_RS07590	COG2137	regulation of response to DNA damage stimulus
EBS_RS07615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EBS_RS07620	COG0033	Phosphoglucomutase
EBS_RS07630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EBS_RS07635	COG0277	FAD linked oxidase domain protein
EBS_RS07645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_RS07650	COG4566	intracellular signal transduction
EBS_RS07655	COG4191	Histidine kinase
EBS_RS07670	COG0795	lipopolysaccharide-transporting ATPase activity
EBS_RS07680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EBS_RS07700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EBS_RS07715	COG0463	Glycosyl transferase, family 2
EBS_RS07720	COG1185	polyribonucleotide nucleotidyltransferase activity
EBS_RS07725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EBS_RS07730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EBS_RS07735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EBS_RS07740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EBS_RS07745	COG0195	Participates in both transcription termination and antitermination
EBS_RS07745	COG2251	uridine kinase activity
EBS_RS07760	COG1007	ATP synthesis coupled electron transport
EBS_RS07775	COG0713	ATP synthesis coupled electron transport
EBS_RS07785	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_RS07790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EBS_RS07795	COG1034	ATP synthesis coupled electron transport
EBS_RS07805	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EBS_RS07810	COG0649	NAD binding
EBS_RS07815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_RS07820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_RS07825	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EBS_RS07840	COG0149	triose-phosphate isomerase activity
EBS_RS07845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EBS_RS07850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EBS_RS07855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EBS_RS07860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EBS_RS07865	COG1534	Rna-binding protein
EBS_RS07870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBS_RS07880	COG0505	Belongs to the CarA family
EBS_RS07885	COG3118	belongs to the thioredoxin family
EBS_RS07890	COG3118	belongs to the thioredoxin family
EBS_RS07895	COG1720	tRNA m6t6A37 methyltransferase activity
EBS_RS07935	COG1126	abc transporter atp-binding protein
EBS_RS07940	COG0765	amino acid transport
EBS_RS07945	COG4597	amino acid ABC transporter
EBS_RS07950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EBS_RS07960	COG1136	(ABC) transporter
EBS_RS07965	COG4591	ABC-type transport system involved in lipoprotein release permease component
EBS_RS07975	COG2957	Belongs to the agmatine deiminase family
EBS_RS07980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBS_RS08020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EBS_RS08030	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EBS_RS08035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EBS_RS08040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EBS_RS08045	COG1674	ftsk spoiiie
EBS_RS08050	COG0686	Belongs to the AlaDH PNT family
EBS_RS08055	COG0492	ferredoxin-NADP+ reductase activity
EBS_RS08070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EBS_RS08075	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EBS_RS08080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EBS_RS08085	COG0542	response to heat
EBS_RS08090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EBS_RS08095	COG1278	Cold shock
EBS_RS08110	COG2204	response regulator
EBS_RS08120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EBS_RS08170	COG2010	Cytochrome c
EBS_RS08175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EBS_RS08190	COG0535	radical SAM domain protein
EBS_RS08215	COG2010	Cytochrome c
EBS_RS08220	COG1648	precorrin-2 dehydrogenase activity
EBS_RS08220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EBS_RS08260	COG2132	Multicopper oxidase
EBS_RS08285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EBS_RS08295	COG1196	nuclear chromosome segregation
EBS_RS08300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EBS_RS08305	COG1070	Carbohydrate kinase
EBS_RS08340	COG0436	Aminotransferase
EBS_RS08350	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EBS_RS08355	COG0166	Belongs to the GPI family
EBS_RS08360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EBS_RS08380	COG2885	chlorophyll binding
EBS_RS08380	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EBS_RS08390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EBS_RS08395	COG0204	Acyl-transferase
EBS_RS08405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EBS_RS08410	COG0750	zinc metalloprotease
EBS_RS08420	COG1469	GTP cyclohydrolase I activity
EBS_RS08430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EBS_RS08440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EBS_RS08445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EBS_RS08500	COG4783	chaperone-mediated protein folding
EBS_RS08565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EBS_RS08575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EBS_RS08580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EBS_RS08610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EBS_RS08615	COG0602	queuosine metabolic process
EBS_RS08625	COG2885	chlorophyll binding
EBS_RS08630	COG0823	Involved in the tonB-independent uptake of proteins
EBS_RS08645	COG0811	peptide transport
EBS_RS08650	COG0824	Thioesterase
EBS_RS08655	COG2255	four-way junction helicase activity
EBS_RS08660	COG0632	four-way junction helicase activity
EBS_RS08665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EBS_RS08690	COG5001	Diguanylate cyclase
EBS_RS08690	COG5002	protein histidine kinase activity
EBS_RS08695	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EBS_RS08720	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EBS_RS08725	COG0300	oxidoreductase activity
EBS_RS08735	COG0793	Belongs to the peptidase S41A family
EBS_RS08750	COG3956	TIGRFAM MazG family protein
EBS_RS08755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EBS_RS08815	COG0129	dihydroxy-acid dehydratase activity
EBS_RS08820	COG5002	protein histidine kinase activity
EBS_RS08820	COG5001	Diguanylate cyclase
EBS_RS08835	COG1309	transcriptional regulator
EBS_RS08855	COG0330	HflC and HflK could
EBS_RS08860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EBS_RS08860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EBS_RS08870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EBS_RS08880	COG0183	Belongs to the thiolase family
EBS_RS08885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBS_RS08895	COG0668	transmembrane transport
EBS_RS08910	COG0835	chemotaxis
EBS_RS08915	COG1192	Involved in chromosome partitioning
EBS_RS08920	COG1360	Flagellar Motor Protein
EBS_RS08925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EBS_RS08930	COG2201	protein-glutamate methylesterase activity
EBS_RS08935	COG0643	Histidine kinase
EBS_RS08935	COG0784	Response regulator, receiver
EBS_RS08935	COG2198	Histidine kinase
EBS_RS08940	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EBS_RS08965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EBS_RS08975	COG1684	flagellar biosynthetic protein fliR
EBS_RS09020	COG2270	Major facilitator Superfamily
EBS_RS09025	COG0842	Transport permease protein
EBS_RS09030	COG1131	(ABC) transporter
EBS_RS09050	COG0456	acetyltransferase
EBS_RS09055	COG1573	uracil-dna glycosylase
EBS_RS09060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EBS_RS09065	COG1183	phosphatidylcholine synthase activity
EBS_RS09070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EBS_RS09075	COG0440	acetolactate synthase activity
EBS_RS09080	COG0028	Belongs to the TPP enzyme family
EBS_RS09090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBS_RS09130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EBS_RS09135	COG0071	Belongs to the small heat shock protein (HSP20) family
EBS_RS09145	COG1509	lysine 2,3-aminomutase activity
EBS_RS09160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EBS_RS09185	COG2205	protein histidine kinase activity
EBS_RS09185	COG0784	Response regulator, receiver
EBS_RS09185	COG5002	protein histidine kinase activity
EBS_RS09220	COG1797	cobyrinic acid a,c-diamide synthase activity
EBS_RS09255	COG2920	part of a sulfur-relay system
EBS_RS09265	COG2923	Belongs to the DsrF TusC family
EBS_RS09270	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EBS_RS09275	COG2221	Nitrite and sulphite reductase 4Fe-4S
EBS_RS09280	COG2221	Nitrite and sulphite reductase 4Fe-4S
EBS_RS09325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EBS_RS09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBS_RS09390	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EBS_RS09405	COG5007	Belongs to the BolA IbaG family
EBS_RS09410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EBS_RS09425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBS_RS09430	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EBS_RS09435	COG1862	Preprotein translocase
EBS_RS09440	COG0343	queuine tRNA-ribosyltransferase activity
EBS_RS09445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EBS_RS09460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EBS_RS09465	COG0134	indole-3-glycerol-phosphate synthase activity
EBS_RS09470	COG0135	phosphoribosylanthranilate isomerase activity
EBS_RS09475	COG1538	Outer membrane efflux protein
EBS_RS09485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EBS_RS09495	COG2900	Belongs to the SlyX family
EBS_RS09500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EBS_RS09500	COG0047	phosphoribosylformylglycinamidine synthase activity
EBS_RS09505	COG0840	transmembrane signaling receptor activity
EBS_RS09510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EBS_RS09515	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EBS_RS09520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EBS_RS09530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EBS_RS09535	COG0446	pyridine nucleotide-disulphide oxidoreductase
EBS_RS09555	COG0697	spore germination
EBS_RS09560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EBS_RS09580	COG0167	dihydroorotate dehydrogenase activity
EBS_RS09605	COG2925	Exonuclease
EBS_RS09610	COG0335	large ribosomal subunit rRNA binding
EBS_RS09615	COG0336	Belongs to the RNA methyltransferase TrmD family
EBS_RS09620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EBS_RS09625	COG0228	four-way junction DNA binding
EBS_RS09645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EBS_RS09685	COG0248	Ppx GppA phosphatase
EBS_RS09695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EBS_RS09715	COG1858	cytochrome C peroxidase
EBS_RS09730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EBS_RS09735	COG0137	argininosuccinate synthase activity
EBS_RS09750	COG0577	efflux transmembrane transporter activity
EBS_RS09750	COG1136	(ABC) transporter
EBS_RS09755	COG1136	(ABC) transporter
EBS_RS09755	COG0577	efflux transmembrane transporter activity
EBS_RS09770	COG1217	gtp-binding protein TYPA
EBS_RS09780	COG0840	transmembrane signaling receptor activity
EBS_RS09790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EBS_RS09805	COG0191	fructose-bisphosphate aldolase activity
EBS_RS09815	COG0126	phosphoglycerate kinase activity
EBS_RS09820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EBS_RS09825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EBS_RS09835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EBS_RS09845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EBS_RS09850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EBS_RS09855	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EBS_RS09865	COG2198	Histidine kinase
EBS_RS09865	COG0643	Histidine kinase
EBS_RS09870	COG0840	transmembrane signaling receptor activity
EBS_RS09910	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EBS_RS09915	COG1678	Uncharacterized ACR, COG1678
EBS_RS09920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EBS_RS09930	COG0540	Belongs to the ATCase OTCase family
EBS_RS09950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EBS_RS09955	COG2832	Protein of unknown function (DUF454)
EBS_RS09960	COG0501	Belongs to the peptidase M48B family
EBS_RS09970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EBS_RS10010	COG1187	pseudouridine synthase activity
EBS_RS10020	COG0247	lactate metabolic process
EBS_RS10050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EBS_RS10055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EBS_RS10060	COG1519	Transferase
EBS_RS10065	COG1560	Kdo2-lipid A biosynthetic process
EBS_RS10075	COG1132	(ABC) transporter
EBS_RS10080	COG1696	Membrane protein involved in D-alanine export
EBS_RS10090	COG2755	lipolytic protein G-D-S-L family
EBS_RS10090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EBS_RS10135	COG0463	Glycosyl transferase, family 2
EBS_RS10155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EBS_RS10160	COG0438	transferase activity, transferring glycosyl groups
EBS_RS10170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EBS_RS10185	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EBS_RS10200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EBS_RS10215	COG1324	tolerance protein
EBS_RS10220	COG4232	protein-disulfide reductase activity
EBS_RS10225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS10230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EBS_RS10235	COG0511	ligase activity, forming carbon-carbon bonds
EBS_RS10240	COG0439	Biotin carboxylase
EBS_RS10245	COG2264	protein methyltransferase activity
EBS_RS10260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EBS_RS10265	COG0138	bifunctional purine biosynthesis protein purh
EBS_RS10290	COG4221	oxidoreductase activity
EBS_RS10330	COG5001	Diguanylate cyclase
EBS_RS10330	COG3300	MHYT domain
EBS_RS10335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EBS_RS10340	COG0151	Belongs to the GarS family
EBS_RS10350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EBS_RS10355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EBS_RS10365	COG1573	uracil-dna glycosylase
EBS_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
EBS_RS10370	COG3321	synthase
EBS_RS10370	COG0604	alcohol dehydrogenase
EBS_RS10375	COG0037	tRNA processing
EBS_RS10390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EBS_RS10400	COG0288	reversible hydration of carbon dioxide
EBS_RS10425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EBS_RS10460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EBS_RS10475	COG2205	protein histidine kinase activity
EBS_RS10475	COG3437	response regulator, receiver
EBS_RS10475	COG3850	Histidine kinase
EBS_RS10475	COG4999	Histidine kinase
EBS_RS10490	COG0012	GTP binding
EBS_RS10500	COG0840	transmembrane signaling receptor activity
EBS_RS10510	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EBS_RS10530	COG1192	Involved in chromosome partitioning
EBS_RS10535	COG0835	chemotaxis
EBS_RS10540	COG0840	transmembrane signaling receptor activity
EBS_RS10550	COG0835	chemotaxis
EBS_RS10555	COG2198	Histidine kinase
EBS_RS10555	COG0643	Histidine kinase
EBS_RS10560	COG0745	RESPONSE REGULATOR receiver
EBS_RS10630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EBS_RS10640	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EBS_RS10645	COG0316	Belongs to the HesB IscA family
EBS_RS10660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EBS_RS10680	COG1981	membrane
EBS_RS10695	COG1773	rubredoxin
EBS_RS10700	COG0351	phosphomethylpyrimidine kinase
EBS_RS10705	COG0352	thiamine-phosphate diphosphorylase activity
EBS_RS10710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EBS_RS10715	COG0586	Pfam SNARE associated Golgi protein
EBS_RS10720	COG0406	alpha-ribazole phosphatase activity
EBS_RS10735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EBS_RS10740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EBS_RS10745	COG1758	RNA polymerase activity
EBS_RS10750	COG0194	GDP metabolic process
EBS_RS10755	COG1561	YicC-like family, N-terminal region
EBS_RS10760	COG0515	serine threonine protein kinase
EBS_RS10770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EBS_RS10775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EBS_RS10800	COG2084	Dehydrogenase
EBS_RS10825	COG0546	phosphoglycolate phosphatase activity
EBS_RS10845	COG0018	arginyl-trna synthetase
EBS_RS10850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EBS_RS10880	COG3001	Fructosamine kinase
EBS_RS10890	COG0789	Transcriptional regulator
EBS_RS10910	COG0004	ammonium transporteR
EBS_RS10915	COG0347	Belongs to the P(II) protein family
EBS_RS10925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EBS_RS10945	COG1132	(ABC) transporter
EBS_RS10985	COG5002	protein histidine kinase activity
EBS_RS11000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EBS_RS11010	COG0573	inorganic phosphate transmembrane transporter activity
EBS_RS11020	COG0488	(ABC) transporter
EBS_RS11035	COG1881	PFAM PEBP family protein
EBS_RS11040	COG2133	pyrroloquinoline quinone binding
EBS_RS11045	COG0459	protein refolding
EBS_RS11050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EBS_RS11075	COG1454	alcohol dehydrogenase
EBS_RS11090	COG3100	YcgL domain-containing protein
EBS_RS11095	COG3830	Belongs to the UPF0237 family
EBS_RS11095	COG0560	Phosphoserine phosphatase
EBS_RS11130	COG0741	lytic transglycosylase activity
EBS_RS11140	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EBS_RS11175	COG3577	Aspartyl protease
EBS_RS11195	COG0714	Associated with various cellular activities
EBS_RS11200	COG1233	COG1233 Phytoene dehydrogenase and related
EBS_RS11205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EBS_RS11215	COG2048	Heterodisulfide reductase, subunit B
EBS_RS11240	COG2204	response regulator
EBS_RS11250	COG1166	arginine decarboxylase activity
EBS_RS11255	COG0583	DNA-binding transcription factor activity
EBS_RS11260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EBS_RS11280	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EBS_RS11295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EBS_RS11300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EBS_RS11320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EBS_RS11325	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EBS_RS11330	COG2321	neutral zinc metallopeptidase
EBS_RS11340	COG0433	COG0433 Predicted ATPase
EBS_RS11345	COG1331	Highly conserved protein containing a thioredoxin domain
EBS_RS11350	COG1999	signal sequence binding
EBS_RS11355	COG2920	part of a sulfur-relay system
EBS_RS11370	COG1022	Amp-dependent synthetase and ligase
EBS_RS11380	COG2022	thiamine diphosphate biosynthetic process
EBS_RS11385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EBS_RS11390	COG3842	ATPase activity
EBS_RS11395	COG0390	transport system, permease component
EBS_RS11405	COG2969	positive regulation of protein catabolic process
EBS_RS11410	COG0625	glutathione transferase activity
EBS_RS11415	COG2857	Cytochrome c1
EBS_RS11420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EBS_RS11425	COG0723	plastoquinol--plastocyanin reductase activity
EBS_RS11430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EBS_RS11445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EBS_RS11460	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
EBS_RS11480	COG1773	rubredoxin
EBS_RS11495	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
EBS_RS11510	COG2204	response regulator
EBS_RS11540	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EBS_RS11560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EBS_RS11565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EBS_RS11570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EBS_RS11585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EBS_RS11590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EBS_RS11595	COG1127	ABC transporter
EBS_RS11615	COG0517	IMP dehydrogenase activity
EBS_RS11615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EBS_RS11620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EBS_RS11635	COG1137	ATPase activity
EBS_RS11645	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EBS_RS11660	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EBS_RS11675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EBS_RS11680	COG0297	glycogen (starch) synthase activity
EBS_RS11685	COG0058	SHG alpha-glucan phosphorylase activity
EBS_RS11710	COG1660	Displays ATPase and GTPase activities
EBS_RS11720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EBS_RS11725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EBS_RS11730	COG2239	Acts as a magnesium transporter
EBS_RS11740	COG3043	anaerobic respiration
EBS_RS11745	COG0348	domain, Protein
EBS_RS11750	COG0437	4 iron, 4 sulfur cluster binding
EBS_RS11770	COG0495	leucyl-tRNA aminoacylation
EBS_RS11805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EBS_RS11810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EBS_RS11860	COG1518	maintenance of DNA repeat elements
EBS_RS11880	COG3220	belongs to the UPF0276 family
EBS_RS11895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EBS_RS11905	COG1530	ribonuclease E activity
EBS_RS11915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EBS_RS11920	COG0312	modulator of DNA gyrase
EBS_RS11925	COG0312	modulator of DNA gyrase
EBS_RS11940	COG1011	Hydrolase
EBS_RS11995	COG3267	Type II secretory pathway component ExeA
EBS_RS11995	COG3409	Peptidoglycan-binding domain 1 protein
EBS_RS12005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EBS_RS12035	COG4968	Prepilin-type N-terminal cleavage methylation domain
EBS_RS12045	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EBS_RS12090	COG0840	transmembrane signaling receptor activity
EBS_RS12105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EBS_RS12105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EBS_RS12115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EBS_RS12120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EBS_RS12125	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EBS_RS12130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EBS_RS12135	COG0509	glycine decarboxylation via glycine cleavage system
EBS_RS12140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EBS_RS12170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EBS_RS12175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EBS_RS12185	COG0315	cyclic pyranopterin monophosphate synthase activity
EBS_RS12190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EBS_RS12195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EBS_RS12200	COG0006	proline dipeptidase activity
EBS_RS12205	COG3079	Belongs to the UPF0149 family
EBS_RS12220	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EBS_RS12225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EBS_RS12230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EBS_RS12235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EBS_RS12245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EBS_RS12260	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EBS_RS12265	COG0457	Tetratricopeptide repeat
EBS_RS12270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EBS_RS12285	COG0070	glutamate synthase
EBS_RS12285	COG0069	glutamate synthase activity
EBS_RS12285	COG0067	glutamate synthase
EBS_RS12295	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EBS_RS12300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EBS_RS12340	COG0039	L-malate dehydrogenase activity
EBS_RS12345	COG0281	malic enzyme
EBS_RS12350	COG0254	rRNA binding
EBS_RS12375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EBS_RS12380	COG0210	DNA helicase
EBS_RS12395	COG3447	MASE1 domain protein
EBS_RS12395	COG5001	Diguanylate cyclase
EBS_RS12395	COG5002	protein histidine kinase activity
EBS_RS12400	COG2204	response regulator
EBS_RS12430	COG2205	protein histidine kinase activity
EBS_RS12430	COG4999	Histidine kinase
EBS_RS12430	COG3850	Histidine kinase
EBS_RS12430	COG3437	response regulator, receiver
EBS_RS12435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EBS_RS12440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EBS_RS12445	COG1047	Peptidyl-prolyl cis-trans
EBS_RS12450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EBS_RS12455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EBS_RS12465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EBS_RS12470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EBS_RS12475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EBS_RS12485	COG0356	it plays a direct role in the translocation of protons across the membrane
EBS_RS12495	COG1475	DNA binding
EBS_RS12500	COG1192	Involved in chromosome partitioning
EBS_RS12505	COG0357	Ribosomal RNA small subunit methyltransferase G
EBS_RS12510	COG0625	glutathione transferase activity
EBS_RS12520	COG3022	response to hydroperoxide
EBS_RS12525	COG0445	tRNA wobble uridine modification
EBS_RS12535	COG0714	Associated with various cellular activities
EBS_RS12550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EBS_RS12555	COG0706	membrane insertase activity
EBS_RS12560	COG0594	ribonuclease P activity
EBS_RS12565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EBS_RS12585	COG1132	(ABC) transporter
EBS_RS12605	COG0563	adenylate kinase activity
EBS_RS12630	COG0653	protein targeting
EBS_RS12650	COG3706	GGDEF domain
EBS_RS12655	COG3107	peptidoglycan biosynthetic process
EBS_RS12685	COG2205	protein histidine kinase activity
EBS_RS12685	COG2198	Histidine kinase
EBS_RS12685	COG0784	Response regulator, receiver
EBS_RS12690	COG0784	Response regulator, receiver
EBS_RS12690	COG5002	protein histidine kinase activity
EBS_RS12690	COG2205	protein histidine kinase activity
EBS_RS12695	COG5002	protein histidine kinase activity
EBS_RS12695	COG5001	Diguanylate cyclase
EBS_RS12785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EBS_RS12785	COG2169	Transcriptional regulator
EBS_RS12790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EBS_RS12810	COG4191	Histidine kinase
EBS_RS12845	COG5002	protein histidine kinase activity
EBS_RS12845	COG5001	Diguanylate cyclase
EBS_RS13035	COG0784	Response regulator, receiver
EBS_RS13035	COG2198	Histidine kinase
EBS_RS13035	COG2205	protein histidine kinase activity
EBS_RS13070	COG0784	Response regulator, receiver
EBS_RS13070	COG2205	protein histidine kinase activity
EBS_RS13070	COG5002	protein histidine kinase activity
EBS_RS13125	COG0840	transmembrane signaling receptor activity
EBS_RS13130	COG0840	transmembrane signaling receptor activity
EBS_RS13145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EBS_RS13155	COG0739	heme binding
EBS_RS13175	COG1396	sequence-specific DNA binding
EBS_RS13220	COG0247	lactate metabolic process