locus-tag	class	description
D5085_RS00025	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D5085_RS00030	COG1222	aaa ATPase
D5085_RS00055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5085_RS00095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5085_RS00100	COG3321	synthase
D5085_RS00100	COG0300	oxidoreductase activity
D5085_RS00100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5085_RS00100	COG4221	oxidoreductase activity
D5085_RS00110	COG2070	2-Nitropropane dioxygenase
D5085_RS00110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5085_RS00140	COG1132	(ABC) transporter
D5085_RS00145	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_RS00150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_RS00155	COG0513	Belongs to the DEAD box helicase family
D5085_RS00165	COG2153	protein acetylation
D5085_RS00190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5085_RS00235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_RS00295	COG4717	serine-type aminopeptidase activity
D5085_RS00300	COG0420	3'-5' exonuclease activity
D5085_RS00305	COG1690	Belongs to the RtcB family
D5085_RS00310	COG3577	Aspartyl protease
D5085_RS00345	COG0058	SHG alpha-glucan phosphorylase activity
D5085_RS00350	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D5085_RS00355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5085_RS00385	COG2210	Belongs to the sulfur carrier protein TusA family
D5085_RS00390	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_RS00395	COG1309	transcriptional regulator
D5085_RS00400	COG3706	GGDEF domain
D5085_RS00405	COG2962	Rard protein
D5085_RS00425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_RS00430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5085_RS00440	COG0303	'Molybdopterin
D5085_RS00445	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5085_RS00450	COG2197	response regulator
D5085_RS00455	COG3850	Histidine kinase
D5085_RS00465	COG2223	nitrite transmembrane transporter activity
D5085_RS00470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D5085_RS00475	COG1140	nitrate reductase beta subunit
D5085_RS00480	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D5085_RS00485	COG2181	nitrate reductase activity
D5085_RS00490	COG2920	part of a sulfur-relay system
D5085_RS00495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5085_RS00500	COG0288	reversible hydration of carbon dioxide
D5085_RS00505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_RS00565	COG3344	reverse transcriptase
D5085_RS00575	COG0494	nUDIX hydrolase
D5085_RS00580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5085_RS00585	COG1074	ATP-dependent DNA helicase activity
D5085_RS00590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_RS00710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS00720	COG3415	Transposase
D5085_RS00720	COG2801	Transposase and inactivated derivatives
D5085_RS00745	COG3436	PFAM IS66 Orf2 family protein
D5085_RS00800	COG4804	nuclease activity
D5085_RS00805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D5085_RS00835	COG0210	DNA helicase
D5085_RS00885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5085_RS00905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5085_RS00905	COG0085	RNA polymerase activity
D5085_RS00905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5085_RS00905	COG0085	RNA polymerase activity
D5085_RS01015	COG3436	PFAM IS66 Orf2 family protein
D5085_RS01050	COG0705	Rhomboid family
D5085_RS01065	COG1199	ATP-dependent helicase activity
D5085_RS01070	COG0629	single-stranded DNA binding
D5085_RS01110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_RS01160	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D5085_RS01225	COG1136	(ABC) transporter
D5085_RS01285	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5085_RS01290	COG2863	cytochrome
D5085_RS01315	COG0315	cyclic pyranopterin monophosphate synthase activity
D5085_RS01335	COG0746	molybdenum cofactor guanylyltransferase activity
D5085_RS01340	COG0840	transmembrane signaling receptor activity
D5085_RS01360	COG2010	Cytochrome c
D5085_RS01385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5085_RS01465	COG2105	PFAM AIG2 family protein
D5085_RS01485	COG1254	Belongs to the acylphosphatase family
D5085_RS01500	COG0393	Putative heavy-metal-binding
D5085_RS01550	COG1595	DNA-templated transcription, initiation
D5085_RS01580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5085_RS01595	COG0457	Tetratricopeptide repeat
D5085_RS01600	COG2914	Belongs to the UPF0125 (RnfH) family
D5085_RS01605	COG2867	negative regulation of translational initiation
D5085_RS01660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D5085_RS01675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5085_RS01680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5085_RS01690	COG1490	D-aminoacyl-tRNA deacylase activity
D5085_RS01700	COG1053	succinate dehydrogenase
D5085_RS01705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_RS01710	COG1256	bacterial-type flagellum assembly
D5085_RS01725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5085_RS01725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5085_RS01730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5085_RS01745	COG1420	regulation of RNA biosynthetic process
D5085_RS01750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5085_RS01755	COG0443	Heat shock 70 kDa protein
D5085_RS01760	COG0484	heat shock protein binding
D5085_RS01765	COG0482	sulfurtransferase activity
D5085_RS01770	COG0840	transmembrane signaling receptor activity
D5085_RS01825	COG0857	belongs to the CobB CobQ family
D5085_RS01825	COG0280	phosphate acetyltransferase
D5085_RS01830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5085_RS01865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_RS01875	COG0802	atpase or kinase
D5085_RS01885	COG4174	ABC transporter (Permease)
D5085_RS01890	COG4166	transmembrane transport
D5085_RS01895	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D5085_RS01905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5085_RS01910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5085_RS01915	COG1862	Preprotein translocase
D5085_RS01925	COG4232	protein-disulfide reductase activity
D5085_RS01955	COG2221	Nitrite and sulphite reductase 4Fe-4S
D5085_RS01965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D5085_RS01970	COG2923	Belongs to the DsrF TusC family
D5085_RS01975	COG2168	tRNA wobble position uridine thiolation
D5085_RS01980	COG2920	part of a sulfur-relay system
D5085_RS02015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5085_RS02020	COG1797	cobyrinic acid a,c-diamide synthase activity
D5085_RS02025	COG1216	Glycosyl transferase, family 2
D5085_RS02030	COG0463	Glycosyl transferase, family 2
D5085_RS02060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5085_RS02115	COG1216	Glycosyl transferase, family 2
D5085_RS02115	COG0438	transferase activity, transferring glycosyl groups
D5085_RS02215	COG3436	PFAM IS66 Orf2 family protein
D5085_RS02230	COG3386	PFAM SMP-30 Gluconolaconase
D5085_RS02300	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_RS02305	COG3657	addiction module killer protein
D5085_RS02340	COG2944	sequence-specific DNA binding
D5085_RS02370	COG2944	sequence-specific DNA binding
D5085_RS02380	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5085_RS02395	COG3436	PFAM IS66 Orf2 family protein
D5085_RS02420	COG1216	Glycosyl transferase, family 2
D5085_RS02425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_RS02460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_RS02500	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_RS02530	COG1166	arginine decarboxylase activity
D5085_RS02535	COG0135	phosphoribosylanthranilate isomerase activity
D5085_RS02540	COG0159	tryptophan synthase activity
D5085_RS02555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5085_RS02580	COG0149	triose-phosphate isomerase activity
D5085_RS02585	COG1160	GTP binding
D5085_RS02595	COG2976	Protein conserved in bacteria
D5085_RS02600	COG0124	histidyl-tRNA synthetase
D5085_RS02610	COG1426	Protein conserved in bacteria
D5085_RS02620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5085_RS02635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5085_RS02665	COG3409	Peptidoglycan-binding domain 1 protein
D5085_RS02665	COG3267	Type II secretory pathway component ExeA
D5085_RS02680	COG0587	DNA-directed DNA polymerase activity
D5085_RS02775	COG4983	Phage plasmid primase, P4 family domain protein
D5085_RS02810	COG0205	6-phosphofructokinase activity
D5085_RS02815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5085_RS02820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5085_RS02825	COG0784	Response regulator, receiver
D5085_RS02825	COG5002	protein histidine kinase activity
D5085_RS02825	COG2205	protein histidine kinase activity
D5085_RS02835	COG1067	ATP-dependent peptidase activity
D5085_RS02840	COG0488	(ABC) transporter
D5085_RS02850	COG0390	transport system, permease component
D5085_RS02855	COG4619	ABC transporter
D5085_RS02865	COG1187	pseudouridine synthase activity
D5085_RS02870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5085_RS02875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5085_RS02880	COG0180	Tryptophanyl-tRNA synthetase
D5085_RS02885	COG1994	Peptidase M50
D5085_RS02890	COG0009	L-threonylcarbamoyladenylate synthase
D5085_RS02895	COG0613	PHP domain protein
D5085_RS02910	COG0071	Belongs to the small heat shock protein (HSP20) family
D5085_RS02915	COG1238	metal cluster binding
D5085_RS02920	COG0784	Response regulator, receiver
D5085_RS02920	COG2205	protein histidine kinase activity
D5085_RS02920	COG5002	protein histidine kinase activity
D5085_RS02955	COG2201	protein-glutamate methylesterase activity
D5085_RS02965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5085_RS02965	COG0546	phosphoglycolate phosphatase activity
D5085_RS02985	COG2270	Major facilitator Superfamily
D5085_RS03015	COG0217	transcriptional regulatory protein
D5085_RS03055	COG1666	GTP binding
D5085_RS03060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5085_RS03065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5085_RS03070	COG5001	Diguanylate cyclase
D5085_RS03070	COG3300	MHYT domain
D5085_RS03080	COG1917	Cupin 2, conserved barrel domain protein
D5085_RS03090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5085_RS03100	COG2363	Small membrane protein
D5085_RS03120	COG3093	addiction module antidote protein HigA
D5085_RS03125	COG3549	Plasmid maintenance system killer
D5085_RS03155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5085_RS03160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5085_RS03165	COG0840	transmembrane signaling receptor activity
D5085_RS03170	COG0835	chemotaxis
D5085_RS03175	COG0643	Histidine kinase
D5085_RS03175	COG2198	Histidine kinase
D5085_RS03180	COG0745	RESPONSE REGULATOR receiver
D5085_RS03185	COG1192	Involved in chromosome partitioning
D5085_RS03220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5085_RS03235	COG0084	hydrolase, TatD family'
D5085_RS03245	COG0835	chemotaxis
D5085_RS03245	COG0784	Response regulator, receiver
D5085_RS03255	COG4191	Histidine kinase
D5085_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5085_RS03260	COG0784	Response regulator, receiver
D5085_RS03260	COG3437	response regulator, receiver
D5085_RS03275	COG3597	protein domain associated with
D5085_RS03330	COG0284	orotidine-5'-phosphate decarboxylase activity
D5085_RS03335	COG5002	protein histidine kinase activity
D5085_RS03335	COG0784	Response regulator, receiver
D5085_RS03335	COG2205	protein histidine kinase activity
D5085_RS03345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5085_RS03365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5085_RS03370	COG0840	transmembrane signaling receptor activity
D5085_RS03415	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D5085_RS03420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5085_RS03420	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D5085_RS03425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5085_RS03430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5085_RS03435	COG0509	glycine decarboxylation via glycine cleavage system
D5085_RS03440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5085_RS03445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5085_RS03450	COG0784	Response regulator, receiver
D5085_RS03450	COG2205	protein histidine kinase activity
D5085_RS03450	COG5002	protein histidine kinase activity
D5085_RS03455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5085_RS03460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5085_RS03465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5085_RS03495	COG1643	Atp-dependent helicase
D5085_RS03505	COG3706	GGDEF domain
D5085_RS03510	COG0617	tRNA 3'-terminal CCA addition
D5085_RS03515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5085_RS03520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5085_RS03525	COG0469	pyruvate kinase activity
D5085_RS03550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5085_RS03560	COG0701	Predicted permease
D5085_RS03575	COG1595	DNA-templated transcription, initiation
D5085_RS03595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5085_RS03600	COG1047	Peptidyl-prolyl cis-trans
D5085_RS03605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5085_RS03615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5085_RS03635	COG1592	Rubrerythrin
D5085_RS03640	COG0840	transmembrane signaling receptor activity
D5085_RS03645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5085_RS03650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D5085_RS03655	COG0826	peptidase U32
D5085_RS03670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5085_RS03680	COG2226	methyltransferase
D5085_RS03695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5085_RS03700	COG0525	valine-tRNA ligase activity
D5085_RS03705	COG2326	polyphosphate kinase activity
D5085_RS03715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5085_RS03720	COG0154	amidase activity
D5085_RS03725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5085_RS03730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5085_RS03740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5085_RS03745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5085_RS03750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5085_RS03760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5085_RS03765	COG2918	glutathione biosynthetic process
D5085_RS03800	COG0367	asparagine synthase
D5085_RS03810	COG2226	methyltransferase
D5085_RS03820	COG0110	maltose O-acetyltransferase activity
D5085_RS03825	COG2226	methyltransferase
D5085_RS03870	COG1215	transferase activity, transferring glycosyl groups
D5085_RS03890	COG0432	Pfam Uncharacterised protein family UPF0047
D5085_RS03900	COG3437	response regulator, receiver
D5085_RS03920	COG0606	chelatase, subunit chli
D5085_RS03930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D5085_RS03945	COG1519	Transferase
D5085_RS03950	COG1560	Kdo2-lipid A biosynthetic process
D5085_RS03970	COG4636	protein conserved in cyanobacteria
D5085_RS04010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS04030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS04035	COG2319	Wd-40 repeat
D5085_RS04035	COG4249	Peptidase C14 caspase catalytic subunit p20
D5085_RS04045	COG4249	Peptidase C14 caspase catalytic subunit p20
D5085_RS04045	COG2319	Wd-40 repeat
D5085_RS04090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS04140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS04215	COG0519	Catalyzes the synthesis of GMP from XMP
D5085_RS04270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5085_RS04280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5085_RS04285	COG1686	Belongs to the peptidase S11 family
D5085_RS04290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5085_RS04295	COG2951	lytic endotransglycosylase activity
D5085_RS04300	COG0772	Belongs to the SEDS family
D5085_RS04305	COG0768	penicillin binding
D5085_RS04310	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D5085_RS04315	COG1792	Involved in formation and maintenance of cell shape
D5085_RS04320	COG1077	Cell shape determining protein MreB Mrl
D5085_RS04330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5085_RS04355	COG0730	response to heat
D5085_RS04370	COG2223	nitrite transmembrane transporter activity
D5085_RS04375	COG1858	cytochrome C peroxidase
D5085_RS04380	COG0492	ferredoxin-NADP+ reductase activity
D5085_RS04385	COG2199	diguanylate cyclase activity
D5085_RS04385	COG2200	EAL domain
D5085_RS04400	COG0825	malonyl-CoA metabolic process
D5085_RS04405	COG4239	(ABC) transporter, permease
D5085_RS04410	COG0493	'glutamate synthase
D5085_RS04415	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5085_RS04420	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5085_RS04445	COG3072	Adenylate cyclase
D5085_RS04450	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_RS04495	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D5085_RS04570	COG3436	PFAM IS66 Orf2 family protein
D5085_RS04595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS04730	COG3842	ATPase activity
D5085_RS04775	COG0735	belongs to the Fur family
D5085_RS04780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5085_RS04785	COG1121	(ABC) transporter
D5085_RS04835	COG0045	succinate-CoA ligase (ADP-forming) activity
D5085_RS04840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5085_RS04855	COG0741	lytic transglycosylase activity
D5085_RS04865	COG2046	Belongs to the sulfate adenylyltransferase family
D5085_RS04870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5085_RS04890	COG0445	tRNA wobble uridine modification
D5085_RS04895	COG0357	Ribosomal RNA small subunit methyltransferase G
D5085_RS04900	COG1192	Involved in chromosome partitioning
D5085_RS04905	COG1475	DNA binding
D5085_RS04915	COG0594	ribonuclease P activity
D5085_RS04920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5085_RS04925	COG0706	membrane insertase activity
D5085_RS04930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5085_RS04950	COG2205	protein histidine kinase activity
D5085_RS04950	COG2202	Pas domain
D5085_RS04990	COG1598	PFAM Uncharacterised protein family UPF0150
D5085_RS05015	COG0859	PFAM glycosyl transferase family 9
D5085_RS05020	COG0859	PFAM glycosyl transferase family 9
D5085_RS05025	COG0438	transferase activity, transferring glycosyl groups
D5085_RS05055	COG3954	Phosphoribulokinase
D5085_RS05060	COG4953	penicillin-binding protein 1C
D5085_RS05075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5085_RS05090	COG1088	dTDP-glucose 4,6-dehydratase activity
D5085_RS05095	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5085_RS05100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5085_RS05115	COG2221	Nitrite and sulphite reductase 4Fe-4S
D5085_RS05120	COG1678	Uncharacterized ACR, COG1678
D5085_RS05125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5085_RS05135	COG2210	Belongs to the sulfur carrier protein TusA family
D5085_RS05140	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_RS05145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_RS05155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5085_RS05160	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5085_RS05165	COG0203	ribosomal protein L17
D5085_RS05170	COG0202	RNA polymerase activity
D5085_RS05175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5085_RS05180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5085_RS05185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5085_RS05190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5085_RS05195	COG0201	protein transport
D5085_RS05200	COG0200	Binds to the 23S rRNA
D5085_RS05205	COG1841	ribosomal large subunit assembly
D5085_RS05210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5085_RS05215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D5085_RS05220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5085_RS05225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D5085_RS05230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5085_RS05235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5085_RS05240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D5085_RS05245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5085_RS05260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5085_RS05265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5085_RS05270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5085_RS05275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5085_RS05280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5085_RS05285	COG0089	rRNA binding
D5085_RS05290	COG0088	Forms part of the polypeptide exit tunnel
D5085_RS05295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5085_RS05300	COG0051	transcription antitermination factor activity, RNA binding
D5085_RS05305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5085_RS05310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5085_RS05315	COG0049	tRNA binding
D5085_RS05330	COG0085	RNA polymerase activity
D5085_RS05335	COG0222	ribosome binding
D5085_RS05340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5085_RS05350	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5085_RS05360	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5085_RS05370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5085_RS05395	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5085_RS05440	COG0784	Response regulator, receiver
D5085_RS05440	COG5002	protein histidine kinase activity
D5085_RS05440	COG2205	protein histidine kinase activity
D5085_RS05445	COG0745	RESPONSE REGULATOR receiver
D5085_RS05450	COG3437	response regulator, receiver
D5085_RS05545	COG3220	belongs to the UPF0276 family
D5085_RS05585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5085_RS05590	COG0440	acetolactate synthase activity
D5085_RS05595	COG0028	Belongs to the TPP enzyme family
D5085_RS05600	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5085_RS05605	COG0840	transmembrane signaling receptor activity
D5085_RS05610	COG0840	transmembrane signaling receptor activity
D5085_RS05610	COG3290	protein histidine kinase activity
D5085_RS05660	COG0589	response to stress
D5085_RS05665	COG0659	secondary active sulfate transmembrane transporter activity
D5085_RS05670	COG0668	transmembrane transport
D5085_RS05685	COG0456	acetyltransferase
D5085_RS05690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5085_RS05695	COG3409	Peptidoglycan-binding domain 1 protein
D5085_RS05695	COG3773	Cell wall hydrolase
D5085_RS05700	COG2983	Belongs to the UPF0260 family
D5085_RS05725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5085_RS05735	COG1136	(ABC) transporter
D5085_RS05740	COG4591	ABC-type transport system involved in lipoprotein release permease component
D5085_RS05745	COG4172	Belongs to the ABC transporter superfamily
D5085_RS05775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5085_RS05850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5085_RS05855	COG0156	8-amino-7-oxononanoate synthase activity
D5085_RS05870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D5085_RS05880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5085_RS05895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5085_RS05910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5085_RS05925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5085_RS05925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5085_RS05930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5085_RS05935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5085_RS06010	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5085_RS06020	COG2201	protein-glutamate methylesterase activity
D5085_RS06045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5085_RS06050	COG1648	precorrin-2 dehydrogenase activity
D5085_RS06050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5085_RS06070	COG3118	belongs to the thioredoxin family
D5085_RS06075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5085_RS06155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5085_RS06175	COG1538	Outer membrane efflux protein
D5085_RS06180	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5085_RS06185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D5085_RS06200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5085_RS06220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D5085_RS06230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_RS06235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_RS06240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5085_RS06250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5085_RS06250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5085_RS06255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5085_RS06285	COG1088	dTDP-glucose 4,6-dehydratase activity
D5085_RS06295	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5085_RS06320	COG1032	radical SAM domain protein
D5085_RS06325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D5085_RS06345	COG3958	Transketolase
D5085_RS06350	COG3959	Transketolase, thiamine diphosphate binding domain
D5085_RS06355	COG1088	dTDP-glucose 4,6-dehydratase activity
D5085_RS06400	COG2089	acid synthase
D5085_RS06405	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D5085_RS06415	COG1012	belongs to the aldehyde dehydrogenase family
D5085_RS06430	COG4310	Domain of unknown function (DUF2172)
D5085_RS06435	COG1083	cytidylyl-transferase
D5085_RS06440	COG1086	Polysaccharide biosynthesis protein
D5085_RS06485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5085_RS06495	COG0546	phosphoglycolate phosphatase activity
D5085_RS06500	COG0564	pseudouridine synthase activity
D5085_RS06505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5085_RS06510	COG3347	Dehydrogenase
D5085_RS06510	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_RS06515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5085_RS06520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5085_RS06525	COG2835	tetraacyldisaccharide 4'-kinase activity
D5085_RS06530	COG1663	tetraacyldisaccharide 4'-kinase activity
D5085_RS06535	COG1177	transmembrane transport
D5085_RS06545	COG3842	ATPase activity
D5085_RS06555	COG2967	ApaG domain
D5085_RS06560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5085_RS06570	COG1530	ribonuclease E activity
D5085_RS06585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5085_RS06595	COG2890	protein-(glutamine-N5) methyltransferase activity
D5085_RS06600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5085_RS06605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5085_RS06625	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5085_RS06630	COG0739	heme binding
D5085_RS06645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5085_RS06650	COG0416	fatty acid biosynthetic process
D5085_RS06655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5085_RS06660	COG1399	metal-binding, possibly nucleic acid-binding protein
D5085_RS06665	COG0424	maF-like protein
D5085_RS06685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5085_RS06700	COG1040	competence protein
D5085_RS06705	COG1196	nuclear chromosome segregation
D5085_RS06735	COG0242	peptide deformylase activity
D5085_RS06740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5085_RS06765	COG0351	phosphomethylpyrimidine kinase
D5085_RS06765	COG0352	thiamine-phosphate diphosphorylase activity
D5085_RS06765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D5085_RS06800	COG0442	prolyl-tRNA aminoacylation
D5085_RS06835	COG3005	denitrification pathway
D5085_RS06905	COG3005	denitrification pathway
D5085_RS07050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5085_RS07055	COG0210	DNA helicase
D5085_RS07070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5085_RS07080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5085_RS07110	COG3012	SEC-C Motif Domain Protein
D5085_RS07185	COG2837	iron assimilation
D5085_RS07195	COG3321	synthase
D5085_RS07195	COG0604	alcohol dehydrogenase
D5085_RS07200	COG0228	four-way junction DNA binding
D5085_RS07205	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5085_RS07210	COG0336	Belongs to the RNA methyltransferase TrmD family
D5085_RS07215	COG0335	large ribosomal subunit rRNA binding
D5085_RS07230	COG4974	Belongs to the 'phage' integrase family
D5085_RS07255	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5085_RS07270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_RS07285	COG1610	YqeY-like protein
D5085_RS07290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5085_RS07300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5085_RS07305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5085_RS07310	COG0537	adenosine 5'-monophosphoramidase activity
D5085_RS07315	COG0140	phosphoribosyl-ATP diphosphatase activity
D5085_RS07320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5085_RS07325	COG0107	imidazoleglycerol-phosphate synthase activity
D5085_RS07330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5085_RS07335	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5085_RS07340	COG0131	Imidazoleglycerol-phosphate dehydratase
D5085_RS07350	COG1765	OsmC-like protein
D5085_RS07410	COG3541	Predicted nucleotidyltransferase
D5085_RS07420	COG3541	Predicted nucleotidyltransferase
D5085_RS07445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_RS07500	COG0210	DNA helicase
D5085_RS07520	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5085_RS07575	COG0732	type I restriction modification DNA specificity domain
D5085_RS07615	COG3436	PFAM IS66 Orf2 family protein
D5085_RS07645	COG3541	Predicted nucleotidyltransferase
D5085_RS07675	COG4467	Involved in initiation control of chromosome replication
D5085_RS07740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_RS07745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5085_RS07785	COG4467	Involved in initiation control of chromosome replication
D5085_RS07825	COG1518	maintenance of DNA repeat elements
D5085_RS07835	COG2814	Major facilitator Superfamily
D5085_RS07840	COG3384	dioxygenase
D5085_RS07855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5085_RS07860	COG0653	protein targeting
D5085_RS07865	COG0739	heme binding
D5085_RS07875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D5085_RS07880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5085_RS07900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5085_RS07905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5085_RS07910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5085_RS07915	COG0772	Belongs to the SEDS family
D5085_RS07920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5085_RS07925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5085_RS07930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5085_RS07935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5085_RS07945	COG3116	cell division
D5085_RS07950	COG0275	rRNA processing
D5085_RS07955	COG2001	Belongs to the MraZ family
D5085_RS07960	COG3001	Fructosamine kinase
D5085_RS07975	COG0714	Associated with various cellular activities
D5085_RS07980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5085_RS07980	COG0543	2 iron, 2 sulfur cluster binding
D5085_RS07985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5085_RS07990	COG0569	domain protein
D5085_RS08000	COG3302	dmso reductase anchor subunit
D5085_RS08005	COG0437	4 iron, 4 sulfur cluster binding
D5085_RS08010	COG0243	molybdopterin cofactor binding
D5085_RS08025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_RS08035	COG0018	arginyl-trna synthetase
D5085_RS08040	COG1741	Belongs to the pirin family
D5085_RS08060	COG0751	glycine-tRNA ligase activity
D5085_RS08070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5085_RS08075	COG0628	permease
D5085_RS08095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5085_RS08100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5085_RS08110	COG3267	Type II secretory pathway component ExeA
D5085_RS08110	COG3409	Peptidoglycan-binding domain 1 protein
D5085_RS08150	COG3555	Aspartyl Asparaginyl beta-hydroxylase
D5085_RS08160	COG0138	bifunctional purine biosynthesis protein purh
D5085_RS08205	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D5085_RS08210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5085_RS08215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D5085_RS08225	COG0512	Glutamine amidotransferase of anthranilate synthase
D5085_RS08230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5085_RS08235	COG0134	indole-3-glycerol-phosphate synthase activity
D5085_RS08240	COG0483	inositol monophosphate 1-phosphatase activity
D5085_RS08255	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5085_RS08275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5085_RS08280	COG1923	regulation of RNA biosynthetic process
D5085_RS08285	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5085_RS08290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5085_RS08310	COG4999	Histidine kinase
D5085_RS08310	COG3850	Histidine kinase
D5085_RS08310	COG2205	protein histidine kinase activity
D5085_RS08310	COG3437	response regulator, receiver
D5085_RS08335	COG4636	protein conserved in cyanobacteria
D5085_RS08350	COG3128	pkhd-type hydroxylase
D5085_RS08355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5085_RS08380	COG1902	pentaerythritol trinitrate reductase activity
D5085_RS08385	COG2814	Major facilitator Superfamily
D5085_RS08410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5085_RS08420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5085_RS08425	COG0546	phosphoglycolate phosphatase activity
D5085_RS08430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5085_RS08435	COG0415	Belongs to the DNA photolyase family
D5085_RS08440	COG1253	flavin adenine dinucleotide binding
D5085_RS08445	COG4536	flavin adenine dinucleotide binding
D5085_RS08455	COG0632	four-way junction helicase activity
D5085_RS08460	COG2255	four-way junction helicase activity
D5085_RS08465	COG0824	Thioesterase
D5085_RS08470	COG0811	peptide transport
D5085_RS08485	COG0823	Involved in the tonB-independent uptake of proteins
D5085_RS08500	COG0602	queuosine metabolic process
D5085_RS08510	COG0488	(ABC) transporter
D5085_RS08540	COG1470	cell adhesion involved in biofilm formation
D5085_RS08540	COG1388	LysM domain
D5085_RS08570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5085_RS08575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5085_RS08580	COG2194	sulfuric ester hydrolase activity
D5085_RS08595	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5085_RS08620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D5085_RS08650	COG1987	bacterial-type flagellum assembly
D5085_RS08655	COG1684	flagellar biosynthetic protein fliR
D5085_RS08660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5085_RS08690	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D5085_RS08695	COG0643	Histidine kinase
D5085_RS08695	COG2198	Histidine kinase
D5085_RS08695	COG0784	Response regulator, receiver
D5085_RS08700	COG2201	protein-glutamate methylesterase activity
D5085_RS08705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5085_RS08715	COG1192	Involved in chromosome partitioning
D5085_RS08725	COG0835	chemotaxis
D5085_RS08755	COG3275	phosphorelay sensor kinase activity
D5085_RS08760	COG1677	Flagellar hook-basal body complex protein FliE
D5085_RS08770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5085_RS08790	COG3144	bacterial-type flagellum assembly
D5085_RS08795	COG0247	lactate metabolic process
D5085_RS08800	COG4942	peptidase
D5085_RS08805	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5085_RS08810	COG0640	Transcriptional regulator
D5085_RS08815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_RS08830	COG0346	lactoylglutathione lyase activity
D5085_RS08840	COG0242	peptide deformylase activity
D5085_RS08870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5085_RS08880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5085_RS08885	COG0493	'glutamate synthase
D5085_RS08890	COG0067	glutamate synthase
D5085_RS08890	COG0069	glutamate synthase activity
D5085_RS08890	COG0070	glutamate synthase
D5085_RS08895	COG0659	secondary active sulfate transmembrane transporter activity
D5085_RS08900	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5085_RS08930	COG1850	ribulose-bisphosphate carboxylase activity
D5085_RS08935	COG2204	response regulator
D5085_RS08940	COG3852	Histidine kinase
D5085_RS08945	COG0471	metal ion transport
D5085_RS08945	COG3273	potassium ion transport
D5085_RS08950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5085_RS08955	COG0583	DNA-binding transcription factor activity
D5085_RS08975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5085_RS08980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5085_RS09005	COG4451	ribulose bisphosphate carboxylase, small
D5085_RS09010	COG1850	ribulose-bisphosphate carboxylase activity
D5085_RS09015	COG0840	transmembrane signaling receptor activity
D5085_RS09030	COG3122	Protein conserved in bacteria
D5085_RS09080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5085_RS09085	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
D5085_RS09090	COG3259	Nickel-dependent hydrogenase
D5085_RS09095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5085_RS09100	COG3264	Mechanosensitive ion channel
D5085_RS09100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D5085_RS09120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D5085_RS09125	COG0450	alkyl hydroperoxide reductase
D5085_RS09135	COG0840	transmembrane signaling receptor activity
D5085_RS09155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5085_RS09160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5085_RS09165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5085_RS09175	COG0215	cysteine-tRNA ligase activity
D5085_RS09185	COG0784	Response regulator, receiver
D5085_RS09185	COG0835	chemotaxis
D5085_RS09210	COG4660	Part of a membrane complex involved in electron transport
D5085_RS09220	COG4658	electron transport chain
D5085_RS09230	COG2878	Part of a membrane complex involved in electron transport
D5085_RS09235	COG4657	Part of a membrane complex involved in electron transport
D5085_RS09250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5085_RS09260	COG1815	bacterial-type flagellum-dependent cell motility
D5085_RS09265	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5085_RS09270	COG4783	chaperone-mediated protein folding
D5085_RS09275	COG0488	(ABC) transporter
D5085_RS09300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5085_RS09310	COG0352	thiamine-phosphate diphosphorylase activity
D5085_RS09315	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5085_RS09320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5085_RS09325	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D5085_RS09350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5085_RS09350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D5085_RS09355	COG2954	triphosphatase activity
D5085_RS09365	COG1472	Belongs to the glycosyl hydrolase 3 family
D5085_RS09385	COG0356	it plays a direct role in the translocation of protons across the membrane
D5085_RS09395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5085_RS09400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5085_RS09405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5085_RS09410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5085_RS09415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5085_RS09420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5085_RS09425	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5085_RS09430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5085_RS09435	COG0459	protein refolding
D5085_RS09520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5085_RS09525	COG0795	lipopolysaccharide-transporting ATPase activity
D5085_RS09530	COG0795	lipopolysaccharide-transporting ATPase activity
D5085_RS09535	COG2814	Major facilitator Superfamily
D5085_RS09540	COG1858	cytochrome C peroxidase
D5085_RS09570	COG1136	(ABC) transporter
D5085_RS09570	COG0577	efflux transmembrane transporter activity
D5085_RS09585	COG0084	hydrolase, TatD family'
D5085_RS09600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5085_RS09620	COG0419	ATPase involved in DNA repair
D5085_RS09635	COG3245	cytochrome
D5085_RS09685	COG1598	PFAM Uncharacterised protein family UPF0150
D5085_RS09730	COG0515	serine threonine protein kinase
D5085_RS09730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS09855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5085_RS09860	COG0163	prenyltransferase activity
D5085_RS09870	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5085_RS09880	COG0840	transmembrane signaling receptor activity
D5085_RS09885	COG2205	protein histidine kinase activity
D5085_RS09905	COG0166	Belongs to the GPI family
D5085_RS09910	COG0563	adenylate kinase activity
D5085_RS09915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5085_RS09920	COG1199	ATP-dependent helicase activity
D5085_RS09935	COG0328	RNA-DNA hybrid ribonuclease activity
D5085_RS09940	COG2226	methyltransferase
D5085_RS09945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5085_RS09950	COG0741	lytic transglycosylase activity
D5085_RS09950	COG1388	LysM domain
D5085_RS09960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5085_RS09965	COG0667	Aldo Keto reductase
D5085_RS09980	COG4771	TonB-dependent receptor
D5085_RS09990	COG5002	protein histidine kinase activity
D5085_RS09990	COG2205	protein histidine kinase activity
D5085_RS09990	COG0784	Response regulator, receiver
D5085_RS10000	COG0728	peptidoglycan biosynthetic process
D5085_RS10005	COG0494	nUDIX hydrolase
D5085_RS10010	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D5085_RS10015	COG0859	PFAM glycosyl transferase family 9
D5085_RS10020	COG0667	Aldo Keto reductase
D5085_RS10025	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D5085_RS10025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5085_RS10045	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D5085_RS10050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5085_RS10060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5085_RS10065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D5085_RS10070	COG0193	aminoacyl-tRNA hydrolase activity
D5085_RS10075	COG0012	GTP binding
D5085_RS10080	COG2703	oxygen carrier activity
D5085_RS10095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5085_RS10095	COG0515	serine threonine protein kinase
D5085_RS10115	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_RS10120	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_RS10125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_RS10130	COG0649	NAD binding
D5085_RS10145	COG1034	ATP synthesis coupled electron transport
D5085_RS10150	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5085_RS10155	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_RS10165	COG0713	ATP synthesis coupled electron transport
D5085_RS10180	COG1007	ATP synthesis coupled electron transport
D5085_RS10185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5085_RS10195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5085_RS10200	COG1138	Cytochrome C-type biogenesis protein
D5085_RS10205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_RS10220	COG0557	exoribonuclease II activity
D5085_RS10225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5085_RS10230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5085_RS10255	COG0659	secondary active sulfate transmembrane transporter activity
D5085_RS10340	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D5085_RS10380	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_RS10390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_RS10625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_RS10640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_RS10705	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5085_RS10715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5085_RS10785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5085_RS10800	COG1216	Glycosyl transferase, family 2
D5085_RS10850	COG3657	addiction module killer protein
D5085_RS10855	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_RS10890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5085_RS10910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5085_RS10915	COG1459	type II secretion system
D5085_RS11025	COG2244	polysaccharide biosynthetic process
D5085_RS11150	COG0463	Glycosyl transferase, family 2
D5085_RS11160	COG2177	Part of the ABC transporter FtsEX involved in
D5085_RS11165	COG2884	Cell division ATP-binding protein ftsE
D5085_RS11175	COG0779	Required for maturation of 30S ribosomal subunits
D5085_RS11180	COG0195	Participates in both transcription termination and antitermination
D5085_RS11180	COG2251	uridine kinase activity
D5085_RS11185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5085_RS11190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5085_RS11195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5085_RS11200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5085_RS11205	COG1185	polyribonucleotide nucleotidyltransferase activity
D5085_RS11210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5085_RS11240	COG0859	PFAM glycosyl transferase family 9
D5085_RS11245	COG3642	lipopolysaccharide core region biosynthetic process
D5085_RS11250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5085_RS11260	COG0308	aminopeptidase N
D5085_RS11290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5085_RS11295	COG4783	chaperone-mediated protein folding
D5085_RS11300	COG0268	Binds directly to 16S ribosomal RNA
D5085_RS11315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D5085_RS11320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5085_RS11325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5085_RS11330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5085_RS11335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5085_RS11340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5085_RS11345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5085_RS11350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5085_RS11365	COG0714	Associated with various cellular activities
D5085_RS11375	COG1194	a g-specific adenine glycosylase
D5085_RS11380	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D5085_RS11420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D5085_RS11440	COG0513	Belongs to the DEAD box helicase family
D5085_RS11445	COG2201	protein-glutamate methylesterase activity
D5085_RS11450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5085_RS11455	COG3842	ATPase activity
D5085_RS11460	COG1178	ABC-type Fe3 transport system permease component
D5085_RS11465	COG1840	ABC-type Fe3 transport system, periplasmic component
D5085_RS11475	COG0194	GDP metabolic process
D5085_RS11485	COG0037	tRNA processing
D5085_RS11505	COG3072	Adenylate cyclase
D5085_RS11550	COG1959	2 iron, 2 sulfur cluster binding
D5085_RS11555	COG1104	cysteine desulfurase activity
D5085_RS11560	COG1104	cysteine desulfurase activity
D5085_RS11565	COG0822	iron-sulfur transferase activity
D5085_RS11570	COG0316	Belongs to the HesB IscA family
D5085_RS11575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5085_RS11580	COG0443	Heat shock 70 kDa protein
D5085_RS11595	COG1555	photosystem II stabilization
D5085_RS11595	COG1596	polysaccharide export
D5085_RS11600	COG0254	rRNA binding
D5085_RS11640	COG0840	transmembrane signaling receptor activity
D5085_RS11645	COG2198	Histidine kinase
D5085_RS11645	COG0643	Histidine kinase
D5085_RS11660	COG0101	tRNA pseudouridine synthase activity
D5085_RS11665	COG0135	phosphoribosylanthranilate isomerase activity
D5085_RS11670	COG0133	tryptophan synthase activity
D5085_RS11675	COG0159	tryptophan synthase activity
D5085_RS11680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5085_RS11685	COG0285	dihydrofolate synthase activity
D5085_RS11695	COG1286	toxin biosynthetic process
D5085_RS11710	COG3100	YcgL domain-containing protein
D5085_RS11715	COG0737	Belongs to the 5'-nucleotidase family
D5085_RS11740	COG0116	Belongs to the methyltransferase superfamily
D5085_RS11740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5085_RS11770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5085_RS11800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D5085_RS11825	COG0432	Pfam Uncharacterised protein family UPF0047
D5085_RS11845	COG3278	Belongs to the heme-copper respiratory oxidase family
D5085_RS11860	COG2010	Cytochrome c
D5085_RS11875	COG2217	Heavy metal translocating P-type atpase
D5085_RS11880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5085_RS11905	COG0835	chemotaxis
D5085_RS11910	COG2201	protein-glutamate methylesterase activity
D5085_RS11920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5085_RS11925	COG0745	RESPONSE REGULATOR receiver
D5085_RS11930	COG2198	Histidine kinase
D5085_RS11930	COG0643	Histidine kinase
D5085_RS11930	COG0643	Histidine kinase
D5085_RS11930	COG2198	Histidine kinase
D5085_RS11940	COG1192	Involved in chromosome partitioning
D5085_RS11945	COG0745	RESPONSE REGULATOR receiver
D5085_RS11960	COG2172	sigma factor antagonist activity
D5085_RS11965	COG2172	sigma factor antagonist activity
D5085_RS11970	COG1366	Belongs to the anti-sigma-factor antagonist family
D5085_RS11975	COG1366	Belongs to the anti-sigma-factor antagonist family
D5085_RS11985	COG0745	RESPONSE REGULATOR receiver
D5085_RS11995	COG0835	chemotaxis
D5085_RS12000	COG0784	Response regulator, receiver
D5085_RS12000	COG2205	protein histidine kinase activity
D5085_RS12000	COG5002	protein histidine kinase activity
D5085_RS12185	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D5085_RS12200	COG2176	DNA-directed DNA polymerase activity
D5085_RS12215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5085_RS12225	COG2226	methyltransferase
D5085_RS12270	COG1051	belongs to the nudix hydrolase family
D5085_RS12280	COG0004	ammonium transporteR
D5085_RS12285	COG0745	RESPONSE REGULATOR receiver
D5085_RS12300	COG4565	transcriptional regulatory protein
D5085_RS12310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5085_RS12315	COG2853	Lipoprotein
D5085_RS12325	COG0482	sulfurtransferase activity
D5085_RS12335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5085_RS12335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5085_RS12350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5085_RS12355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5085_RS12360	COG0006	proline dipeptidase activity
D5085_RS12370	COG4968	Prepilin-type N-terminal cleavage methylation domain
D5085_RS12395	COG1295	ribonuclease BN
D5085_RS12410	COG0542	response to heat
D5085_RS12415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5085_RS12420	COG2814	Major facilitator Superfamily
D5085_RS12425	COG0793	Belongs to the peptidase S41A family
D5085_RS12430	COG2861	carbohydrate metabolic process
D5085_RS12440	COG0181	hydroxymethylbilane synthase activity
D5085_RS12445	COG1587	Uroporphyrinogen-III synthase
D5085_RS12530	COG2239	Acts as a magnesium transporter
D5085_RS12540	COG4786	Flagellar basal body rod
D5085_RS12545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D5085_RS12550	COG1706	bacterial-type flagellum-dependent cell motility
D5085_RS12585	COG0714	Associated with various cellular activities
D5085_RS12600	COG1573	uracil-dna glycosylase
D5085_RS12605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5085_RS12615	COG0505	Belongs to the CarA family
D5085_RS12625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5085_RS12630	COG1534	Rna-binding protein
D5085_RS12635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5085_RS12645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5085_RS12695	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5085_RS12710	COG0830	nickel cation binding
D5085_RS12735	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D5085_RS12745	COG3597	protein domain associated with
D5085_RS12780	COG0426	domain, Protein
D5085_RS12785	COG0633	Ferredoxin
D5085_RS12825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D5085_RS12830	COG3177	Filamentation induced by cAMP protein fic
D5085_RS12835	COG0732	type I restriction modification DNA specificity domain
D5085_RS12845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D5085_RS12895	COG0004	ammonium transporteR
D5085_RS12900	COG0347	Belongs to the P(II) protein family
D5085_RS12905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5085_RS12915	COG0360	Binds together with S18 to 16S ribosomal RNA
D5085_RS12930	COG0359	binds to the 23S rRNA
D5085_RS12935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5085_RS12940	COG0305	Participates in initiation and elongation during chromosome replication
D5085_RS12945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5085_RS12955	COG2995	paraquat-inducible protein a
D5085_RS12960	COG3008	intermembrane lipid transfer
D5085_RS12970	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D5085_RS12985	COG5002	protein histidine kinase activity
D5085_RS12985	COG0784	Response regulator, receiver
D5085_RS12985	COG2205	protein histidine kinase activity
D5085_RS12990	COG3437	response regulator, receiver
D5085_RS12995	COG3437	response regulator, receiver
D5085_RS13000	COG4999	Histidine kinase
D5085_RS13000	COG3850	Histidine kinase
D5085_RS13000	COG3437	response regulator, receiver
D5085_RS13000	COG2205	protein histidine kinase activity
D5085_RS13010	COG0589	response to stress
D5085_RS13020	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5085_RS13045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D5085_RS13045	COG1918	ferrous iron import across plasma membrane
D5085_RS13060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5085_RS13075	COG1115	amino acid carrier protein
D5085_RS13080	COG2197	response regulator
D5085_RS13105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5085_RS13115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5085_RS13120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5085_RS13120	COG0730	response to heat
D5085_RS13125	COG0457	Tetratricopeptide repeat
D5085_RS13130	COG1704	LemA family
D5085_RS13160	COG4818	TM2 domain
D5085_RS13165	COG2211	Major facilitator Superfamily
D5085_RS13175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5085_RS13250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5085_RS13275	COG2003	Belongs to the UPF0758 family
D5085_RS13280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5085_RS13295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5085_RS13300	COG1234	tRNA 3'-trailer cleavage
D5085_RS13305	COG0742	ribosomal rna small subunit methyltransferase
D5085_RS13320	COG2925	Exonuclease
D5085_RS13345	COG1702	phosphate starvation-inducible protein PhoH
D5085_RS13350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5085_RS13355	COG4535	Mg2 and Co2 transporter CorC
D5085_RS13360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5085_RS13370	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D5085_RS13380	COG0375	protein maturation
D5085_RS13385	COG0298	carbon dioxide binding
D5085_RS13415	COG2716	regulation of RNA biosynthetic process
D5085_RS13445	COG4181	ATPase activity
D5085_RS13450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D5085_RS13455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_RS13460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5085_RS13465	COG0418	dihydroorotase activity
D5085_RS13475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5085_RS13515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5085_RS13525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5085_RS13530	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D5085_RS13535	COG0205	6-phosphofructokinase activity
D5085_RS13555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5085_RS13560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5085_RS13575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D5085_RS13580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5085_RS13585	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5085_RS13595	COG0300	oxidoreductase activity
D5085_RS13605	COG0784	Response regulator, receiver
D5085_RS13605	COG0835	chemotaxis
D5085_RS13615	COG0501	Belongs to the peptidase M48B family
D5085_RS13705	COG1981	membrane
D5085_RS13710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5085_RS13725	COG0316	Belongs to the HesB IscA family
D5085_RS13735	COG1879	ABC-type sugar transport system periplasmic component
D5085_RS13740	COG2198	Histidine kinase
D5085_RS13740	COG0784	Response regulator, receiver
D5085_RS13740	COG5002	protein histidine kinase activity
D5085_RS13750	COG2197	response regulator
D5085_RS13755	COG4585	Histidine kinase
D5085_RS13790	COG0758	DNA mediated transformation
D5085_RS13795	COG2922	Belongs to the Smg family
D5085_RS13810	COG1469	GTP cyclohydrolase I activity
D5085_RS13815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5085_RS13820	COG0142	geranyltranstransferase activity
D5085_RS13825	COG1722	exodeoxyribonuclease VII activity
D5085_RS13835	COG0500	methyltransferase
D5085_RS13840	COG4106	trans-aconitate 2-methyltransferase activity
D5085_RS13860	COG1720	tRNA m6t6A37 methyltransferase activity
D5085_RS13870	COG3706	GGDEF domain
D5085_RS13880	COG2255	four-way junction helicase activity
D5085_RS13885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5085_RS13895	COG5002	protein histidine kinase activity
D5085_RS13895	COG5001	Diguanylate cyclase
D5085_RS13900	COG1509	lysine 2,3-aminomutase activity
D5085_RS13905	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5085_RS13915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D5085_RS13930	COG0277	FAD linked oxidase domain protein
D5085_RS13935	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5085_RS13940	COG0792	nuclease activity
D5085_RS13945	COG3107	peptidoglycan biosynthetic process
D5085_RS13955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5085_RS13960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5085_RS13965	COG0126	phosphoglycerate kinase activity
D5085_RS13970	COG0469	pyruvate kinase activity
D5085_RS13995	COG2217	Heavy metal translocating P-type atpase
D5085_RS14000	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_RS14000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_RS14030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5085_RS14035	COG1758	RNA polymerase activity
D5085_RS14045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5085_RS14055	COG0473	3-isopropylmalate dehydrogenase activity
D5085_RS14065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5085_RS14065	COG0678	peroxiredoxin activity
D5085_RS14070	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5085_RS14090	COG3436	PFAM IS66 Orf2 family protein
D5085_RS14125	COG1132	(ABC) transporter
D5085_RS14135	COG0811	peptide transport
D5085_RS14145	COG1570	exodeoxyribonuclease VII activity
D5085_RS14165	COG0840	transmembrane signaling receptor activity
D5085_RS14170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5085_RS14190	COG3864	Putative metallopeptidase domain
D5085_RS14210	COG3321	synthase
D5085_RS14210	COG0604	alcohol dehydrogenase
D5085_RS14215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5085_RS14230	COG2833	Protein of unknown function (DUF455)
D5085_RS14235	COG3038	cytochrome b561
D5085_RS14245	COG0617	tRNA 3'-terminal CCA addition
D5085_RS14250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5085_RS14255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D5085_RS14260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5085_RS14265	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D5085_RS14275	COG0489	protein tyrosine kinase activity
D5085_RS14280	COG5001	Diguanylate cyclase
D5085_RS14280	COG5002	protein histidine kinase activity
D5085_RS14285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5085_RS14285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5085_RS14310	COG0495	leucyl-tRNA aminoacylation
D5085_RS14315	COG0481	GTPase activity
D5085_RS14335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5085_RS14350	COG1639	'signal transduction protein
D5085_RS14360	COG1968	undecaprenyl-diphosphatase activity
D5085_RS14370	COG3630	sodium ion export across plasma membrane
D5085_RS14375	COG0511	ligase activity, forming carbon-carbon bonds
D5085_RS14375	COG5016	pyruvate
D5085_RS14380	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D5085_RS14385	COG0583	DNA-binding transcription factor activity
D5085_RS14390	COG0670	Belongs to the BI1 family
D5085_RS14395	COG0497	DNA recombination
D5085_RS14415	COG0439	Biotin carboxylase
D5085_RS14420	COG0511	ligase activity, forming carbon-carbon bonds
D5085_RS14425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5085_RS14460	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5085_RS14465	COG3439	Domain of unknown function DUF302
D5085_RS14480	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5085_RS14485	COG0129	dihydroxy-acid dehydratase activity
D5085_RS14490	COG3437	response regulator, receiver
D5085_RS14490	COG0784	Response regulator, receiver
D5085_RS14505	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D5085_RS14510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5085_RS14515	COG0363	glucosamine-6-phosphate deaminase activity
D5085_RS14525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5085_RS14530	COG3106	COG3106 Predicted ATPase
D5085_RS14535	COG3768	UPF0283 membrane protein
D5085_RS14545	COG1473	amidohydrolase
D5085_RS14555	COG0006	proline dipeptidase activity
D5085_RS14560	COG1012	belongs to the aldehyde dehydrogenase family
D5085_RS14565	COG1126	abc transporter atp-binding protein
D5085_RS14580	COG0765	amino acid transport
D5085_RS14585	COG4597	amino acid ABC transporter
D5085_RS14590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5085_RS14595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5085_RS14600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5085_RS14605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5085_RS14615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5085_RS14620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D5085_RS14625	COG0631	protein serine/threonine phosphatase activity
D5085_RS14630	COG4991	sh3 domain protein
D5085_RS14630	COG3064	Membrane
D5085_RS14630	COG0515	serine threonine protein kinase
D5085_RS14635	COG1561	YicC-like family, N-terminal region
D5085_RS14645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5085_RS14655	COG2204	response regulator
D5085_RS14660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D5085_RS14670	COG0436	Aminotransferase
D5085_RS14690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5085_RS14710	COG1660	Displays ATPase and GTPase activities
D5085_RS14715	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D5085_RS14725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5085_RS14730	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5085_RS14735	COG1137	ATPase activity
D5085_RS14750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5085_RS14755	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D5085_RS14760	COG0024	Methionine aminopeptidase
D5085_RS14765	COG0052	Belongs to the universal ribosomal protein uS2 family
D5085_RS14770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5085_RS14775	COG0528	UMP kinase activity
D5085_RS14785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5085_RS14790	COG0575	Belongs to the CDS family
D5085_RS14795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5085_RS14820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5085_RS14825	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5085_RS14830	COG1196	nuclear chromosome segregation
D5085_RS14860	COG0842	Transport permease protein
D5085_RS14865	COG1131	(ABC) transporter
D5085_RS14880	COG0402	S-adenosylhomocysteine deaminase activity
D5085_RS14885	COG2850	peptidyl-arginine hydroxylation
D5085_RS14890	COG0542	response to heat
D5085_RS14895	COG4999	Histidine kinase
D5085_RS14895	COG3850	Histidine kinase
D5085_RS14895	COG3437	response regulator, receiver
D5085_RS14895	COG2205	protein histidine kinase activity
D5085_RS14900	COG1879	ABC-type sugar transport system periplasmic component
D5085_RS14910	COG5002	protein histidine kinase activity
D5085_RS14910	COG0784	Response regulator, receiver
D5085_RS14930	COG3437	response regulator, receiver
D5085_RS14945	COG0724	RNA recognition motif
D5085_RS14975	COG2274	protein secretion by the type I secretion system
D5085_RS14990	COG0776	regulation of translation
D5085_RS15010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5085_RS15020	COG2770	Histidine kinase
D5085_RS15020	COG3437	response regulator, receiver
D5085_RS15025	COG4191	Histidine kinase
D5085_RS15035	COG0527	aspartate kinase activity
D5085_RS15040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5085_RS15050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5085_RS15075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5085_RS15100	COG2119	membrane
D5085_RS15130	COG0840	transmembrane signaling receptor activity
D5085_RS15135	COG0835	chemotaxis
D5085_RS15145	COG0643	Histidine kinase
D5085_RS15145	COG2198	Histidine kinase
D5085_RS15155	COG0745	RESPONSE REGULATOR receiver
D5085_RS15160	COG0840	transmembrane signaling receptor activity
D5085_RS15185	COG0735	belongs to the Fur family
D5085_RS15200	COG0733	neurotransmitter:sodium symporter activity
D5085_RS15210	COG0330	HflC and HflK could
D5085_RS15260	COG1459	type II secretion system
D5085_RS15275	COG3031	protein transport across the cell outer membrane
D5085_RS15280	COG0343	queuine tRNA-ribosyltransferase activity
D5085_RS15290	COG0835	chemotaxis
D5085_RS15295	COG0745	RESPONSE REGULATOR receiver
D5085_RS15310	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
D5085_RS15360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5085_RS15410	COG5001	Diguanylate cyclase
D5085_RS15420	COG3437	response regulator, receiver
D5085_RS15420	COG0784	Response regulator, receiver
D5085_RS15425	COG4191	Histidine kinase
D5085_RS15460	COG3437	response regulator, receiver
D5085_RS15460	COG0784	Response regulator, receiver
D5085_RS15495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5085_RS15495	COG0617	tRNA 3'-terminal CCA addition
D5085_RS15495	COG0517	IMP dehydrogenase activity
D5085_RS15505	COG2198	Histidine kinase
D5085_RS15505	COG0784	Response regulator, receiver
D5085_RS15505	COG5002	protein histidine kinase activity
D5085_RS15510	COG3437	response regulator, receiver
D5085_RS15515	COG0784	Response regulator, receiver
D5085_RS15515	COG5002	protein histidine kinase activity
D5085_RS15515	COG2198	Histidine kinase
D5085_RS15545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5085_RS15550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5085_RS15580	COG0840	transmembrane signaling receptor activity
D5085_RS15595	COG0724	RNA recognition motif
D5085_RS15600	COG2915	High frequency lysogenization protein hflD homolog
D5085_RS15605	COG0837	glucose binding
D5085_RS15610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5085_RS15620	COG1640	4-alpha-glucanotransferase
D5085_RS15625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D5085_RS15630	COG0297	glycogen (starch) synthase activity
D5085_RS15635	COG0058	SHG alpha-glucan phosphorylase activity
D5085_RS15640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5085_RS15650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D5085_RS15660	COG0151	Belongs to the GarS family
D5085_RS15675	COG0742	ribosomal rna small subunit methyltransferase
D5085_RS15680	COG0612	Peptidase, M16
D5085_RS15685	COG0612	Peptidase, M16
D5085_RS15690	COG0552	protein localization to endoplasmic reticulum
D5085_RS15705	COG2200	EAL domain
D5085_RS15730	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5085_RS15795	COG0745	RESPONSE REGULATOR receiver
D5085_RS15800	COG2205	protein histidine kinase activity
D5085_RS15860	COG3436	PFAM IS66 Orf2 family protein
D5085_RS15880	COG5002	protein histidine kinase activity
D5085_RS15885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5085_RS15890	COG1518	maintenance of DNA repeat elements
D5085_RS15905	COG1857	crispr-associated protein
D5085_RS15970	COG3300	MHYT domain
D5085_RS15970	COG5001	Diguanylate cyclase
D5085_RS15990	COG2350	Protein conserved in bacteria
D5085_RS16000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5085_RS16015	COG0527	aspartate kinase activity
D5085_RS16025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5085_RS16030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5085_RS16035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5085_RS16045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5085_RS16090	COG2914	Belongs to the UPF0125 (RnfH) family
D5085_RS16100	COG4659	FMN binding
D5085_RS16105	COG4658	electron transport chain
D5085_RS16110	COG4656	Part of a membrane complex involved in electron transport
D5085_RS16115	COG2878	Part of a membrane complex involved in electron transport
D5085_RS16120	COG4657	Part of a membrane complex involved in electron transport
D5085_RS16175	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5085_RS16180	COG0326	Molecular chaperone. Has ATPase activity
D5085_RS16185	COG0033	Phosphoglucomutase
D5085_RS16215	COG5002	protein histidine kinase activity
D5085_RS16215	COG0784	Response regulator, receiver
D5085_RS16215	COG2205	protein histidine kinase activity
D5085_RS16220	COG2205	protein histidine kinase activity
D5085_RS16220	COG5002	protein histidine kinase activity
D5085_RS16220	COG0784	Response regulator, receiver
D5085_RS16230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5085_RS16235	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D5085_RS16245	COG0850	regulation of cytokinetic process
D5085_RS16255	COG2022	thiamine diphosphate biosynthetic process
D5085_RS16260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5085_RS16285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5085_RS16290	COG4536	flavin adenine dinucleotide binding
D5085_RS16310	COG2308	Evidence 4 Homologs of previously reported genes of
D5085_RS16370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5085_RS16375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5085_RS16390	COG0776	regulation of translation
D5085_RS16395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5085_RS16400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5085_RS16405	COG0740	serine-type endopeptidase activity
D5085_RS16410	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5085_RS16425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5085_RS16440	COG0540	Belongs to the ATCase OTCase family
D5085_RS16445	COG1183	phosphatidylcholine synthase activity
D5085_RS16460	COG0165	Argininosuccinate lyase
D5085_RS16465	COG2945	thiolester hydrolase activity
D5085_RS16475	COG2197	response regulator
D5085_RS16480	COG0563	adenylate kinase activity
D5085_RS16485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5085_RS16495	COG0625	glutathione transferase activity
D5085_RS16500	COG0717	Belongs to the dCTP deaminase family
D5085_RS16505	COG3066	DNA modification
D5085_RS16555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5085_RS16560	COG0784	Response regulator, receiver
D5085_RS16560	COG2205	protein histidine kinase activity
D5085_RS16560	COG5002	protein histidine kinase activity
D5085_RS16585	COG5002	protein histidine kinase activity
D5085_RS16585	COG2205	protein histidine kinase activity
D5085_RS16585	COG0784	Response regulator, receiver
D5085_RS16590	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D5085_RS16595	COG0720	synthase
D5085_RS16605	COG2239	Acts as a magnesium transporter
D5085_RS16610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5085_RS16615	COG0022	dehydrogenase e1 component
D5085_RS16615	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5085_RS16620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5085_RS16625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5085_RS16630	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5085_RS16640	COG0330	HflC and HflK could
D5085_RS16645	COG0330	HflC and HflK could
D5085_RS16655	COG0436	Aminotransferase
D5085_RS16660	COG2171	N-acyltransferase activity
D5085_RS16665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5085_RS16670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D5085_RS16685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5085_RS16705	COG1196	nuclear chromosome segregation
D5085_RS16715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5085_RS16740	COG1965	Belongs to the frataxin family
D5085_RS16755	COG2274	protein secretion by the type I secretion system
D5085_RS16775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5085_RS16780	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5085_RS16790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5085_RS16795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5085_RS16810	COG2154	pterin-4-alpha-carbinolamine dehydratase
D5085_RS16820	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5085_RS16820	COG0493	'glutamate synthase
D5085_RS16825	COG0649	NAD binding
D5085_RS16830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_RS16830	COG0649	NAD binding
D5085_RS16835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5085_RS16845	COG0651	ATP synthesis coupled electron transport
D5085_RS16850	COG1006	Multisubunit Na H antiporter MnhC subunit
D5085_RS16855	COG2111	Na H antiporter
D5085_RS16870	COG2212	antiporter activity
D5085_RS16895	COG3005	denitrification pathway
D5085_RS16900	COG2863	cytochrome
D5085_RS16905	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5085_RS16910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5085_RS16920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5085_RS16970	COG5265	(ABC) transporter
D5085_RS16985	COG1562	ergosterol biosynthetic process
D5085_RS16990	COG1562	ergosterol biosynthetic process
D5085_RS16995	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D5085_RS17000	COG1028	Short-chain dehydrogenase reductase Sdr
D5085_RS17010	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D5085_RS17020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5085_RS17025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5085_RS17030	COG0287	Prephenate dehydrogenase
D5085_RS17035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5085_RS17040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5085_RS17045	COG1605	Chorismate mutase
D5085_RS17045	COG0077	Prephenate dehydratase
D5085_RS17050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5085_RS17055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5085_RS17065	COG2969	positive regulation of protein catabolic process
D5085_RS17070	COG0625	glutathione transferase activity
D5085_RS17075	COG2857	Cytochrome c1
D5085_RS17080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5085_RS17085	COG0723	plastoquinol--plastocyanin reductase activity
D5085_RS17090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5085_RS17110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5085_RS17110	COG0574	Belongs to the PEP-utilizing enzyme family
D5085_RS17115	COG2165	general secretion pathway protein
D5085_RS17120	COG0859	PFAM glycosyl transferase family 9
D5085_RS17120	COG0457	Tetratricopeptide repeat
D5085_RS17145	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D5085_RS17175	COG1943	Transposase
D5085_RS17190	COG0756	dUTP diphosphatase activity
D5085_RS17195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5085_RS17205	COG2205	protein histidine kinase activity
D5085_RS17205	COG2202	Pas domain
D5085_RS17225	COG1444	tRNA N-acetyltransferase activity
D5085_RS17245	COG4206	TonB-dependent receptor
D5085_RS17250	COG0009	L-threonylcarbamoyladenylate synthase
D5085_RS17255	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5085_RS17265	COG3437	response regulator, receiver
D5085_RS17270	COG0438	transferase activity, transferring glycosyl groups
D5085_RS17285	COG0745	RESPONSE REGULATOR receiver
D5085_RS17290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D5085_RS17290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D5085_RS17295	COG5002	protein histidine kinase activity
D5085_RS17295	COG2205	protein histidine kinase activity
D5085_RS17295	COG0784	Response regulator, receiver
D5085_RS17310	COG2217	Heavy metal translocating P-type atpase
D5085_RS17325	COG1960	acyl-CoA dehydrogenase activity
D5085_RS17335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5085_RS17350	COG0003	Pfam Anion-transporting ATPase
D5085_RS17365	COG1047	Peptidyl-prolyl cis-trans
D5085_RS17390	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D5085_RS17405	COG3657	addiction module killer protein
D5085_RS17410	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5085_RS17420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5085_RS17445	COG2205	protein histidine kinase activity
D5085_RS17445	COG0784	Response regulator, receiver
D5085_RS17445	COG2198	Histidine kinase
D5085_RS17450	COG2197	response regulator
D5085_RS17460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5085_RS17520	COG0247	lactate metabolic process
D5085_RS17535	COG0424	maF-like protein
D5085_RS17540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5085_RS17550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5085_RS17560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5085_RS17570	COG3321	synthase
D5085_RS17570	COG0604	alcohol dehydrogenase
D5085_RS17590	COG0372	Belongs to the citrate synthase family
D5085_RS17595	COG0436	Aminotransferase
D5085_RS17600	COG2133	pyrroloquinoline quinone binding
D5085_RS17610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5085_RS17615	COG1846	Transcriptional regulator
D5085_RS17625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5085_RS17630	COG1917	Cupin 2, conserved barrel domain protein
D5085_RS17645	COG1011	Hydrolase
D5085_RS17650	COG1218	3'(2'),5'-bisphosphate nucleotidase
D5085_RS17655	COG0367	asparagine synthase
D5085_RS17670	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5085_RS17675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5085_RS17685	COG4133	protoheme IX ABC transporter activity
D5085_RS17695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5085_RS17720	COG1090	epimerase
D5085_RS17775	COG3156	type II secretion system protein K
D5085_RS17790	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5085_RS17795	COG0443	Heat shock 70 kDa protein
D5085_RS17815	COG1671	Belongs to the UPF0178 family
D5085_RS17820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5085_RS17825	COG0840	transmembrane signaling receptor activity
D5085_RS17840	COG0745	RESPONSE REGULATOR receiver
D5085_RS17845	COG0784	Response regulator, receiver
D5085_RS17845	COG2205	protein histidine kinase activity
D5085_RS17850	COG0745	RESPONSE REGULATOR receiver
D5085_RS17865	COG1238	metal cluster binding
D5085_RS17870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5085_RS17875	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5085_RS17890	COG1459	type II secretion system
D5085_RS17900	COG0167	dihydroorotate dehydrogenase activity
D5085_RS17905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5085_RS17910	COG1320	monovalent cation:proton antiporter activity
D5085_RS17915	COG2212	antiporter activity
D5085_RS17920	COG1863	multisubunit Na H antiporter MnhE subunit
D5085_RS17925	COG0651	ATP synthesis coupled electron transport
D5085_RS17930	COG1006	Multisubunit Na H antiporter MnhC subunit
D5085_RS17935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5085_RS17935	COG2111	Na H antiporter
D5085_RS17940	COG0366	Alpha amylase catalytic
D5085_RS17945	COG1215	transferase activity, transferring glycosyl groups
D5085_RS17990	COG0281	malic enzyme
D5085_RS17995	COG0196	riboflavin kinase activity
D5085_RS18000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5085_RS18010	COG0514	ATP-dependent DNA helicase (RecQ)
D5085_RS18055	COG4942	peptidase
D5085_RS18075	COG0745	RESPONSE REGULATOR receiver
D5085_RS18085	COG0704	Plays a role in the regulation of phosphate uptake
D5085_RS18090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5085_RS18095	COG0581	inorganic phosphate transmembrane transporter activity
D5085_RS18100	COG0573	inorganic phosphate transmembrane transporter activity
D5085_RS18105	COG1653	transport
D5085_RS18115	COG2203	Gaf domain
D5085_RS18115	COG3706	GGDEF domain
D5085_RS18115	COG4251	negative regulation of phosphorylation
D5085_RS18115	COG5001	Diguanylate cyclase
D5085_RS18135	COG0516	GMP reductase activity
D5085_RS18135	COG0517	IMP dehydrogenase activity
D5085_RS18155	COG0436	Aminotransferase
D5085_RS18160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5085_RS18170	COG0425	Belongs to the sulfur carrier protein TusA family
D5085_RS18170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5085_RS18175	COG2183	response to ionizing radiation
D5085_RS18185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5085_RS18190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5085_RS18210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5085_RS18215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5085_RS18220	COG5002	protein histidine kinase activity
D5085_RS18220	COG2205	protein histidine kinase activity
D5085_RS18220	COG0784	Response regulator, receiver
D5085_RS18225	COG0784	Response regulator, receiver
D5085_RS18225	COG2205	protein histidine kinase activity
D5085_RS18225	COG5002	protein histidine kinase activity
D5085_RS18230	COG2048	Heterodisulfide reductase, subunit B
D5085_RS18235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5085_RS18245	COG1233	COG1233 Phytoene dehydrogenase and related
D5085_RS18250	COG0142	geranyltranstransferase activity
D5085_RS18290	COG0174	glutamine synthetase
D5085_RS18295	COG3852	Histidine kinase
D5085_RS18325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5085_RS18340	COG0189	ligase activity
D5085_RS18435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5085_RS18440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5085_RS18445	COG0148	phosphopyruvate hydratase activity
D5085_RS18450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5085_RS18455	COG0504	CTP synthase activity
D5085_RS18460	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D5085_RS18465	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5085_RS18480	COG0137	argininosuccinate synthase activity
D5085_RS18485	COG5002	protein histidine kinase activity
D5085_RS18485	COG5001	Diguanylate cyclase
D5085_RS18490	COG1765	OsmC-like protein
D5085_RS18495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5085_RS18495	COG0519	Catalyzes the synthesis of GMP from XMP
D5085_RS18510	COG2020	methyltransferase activity
D5085_RS18530	COG0189	ligase activity
D5085_RS18535	COG4067	protein conserved in archaea
D5085_RS18535	COG0189	ligase activity
D5085_RS18540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5085_RS18545	COG0494	nUDIX hydrolase
D5085_RS18550	COG3022	response to hydroperoxide
D5085_RS18565	COG2197	response regulator
D5085_RS18590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5085_RS18605	COG0776	regulation of translation
D5085_RS18610	COG0072	phenylalanine-tRNA ligase activity
D5085_RS18615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5085_RS18620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5085_RS18625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D5085_RS18630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5085_RS18635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5085_RS18655	COG3118	belongs to the thioredoxin family
D5085_RS18665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5085_RS18670	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D5085_RS18680	COG0019	diaminopimelate decarboxylase activity
D5085_RS18685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D5085_RS18695	COG0529	Catalyzes the synthesis of activated sulfate
D5085_RS18705	COG0517	IMP dehydrogenase activity
D5085_RS18705	COG0516	GMP reductase activity
D5085_RS18715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family