locus-tag	class	description
D5125_RS00020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D5125_RS00060	COG0482	sulfurtransferase activity
D5125_RS00065	COG2915	High frequency lysogenization protein hflD homolog
D5125_RS00070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5125_RS00075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5125_RS00085	COG0437	4 iron, 4 sulfur cluster binding
D5125_RS00090	COG0243	molybdopterin cofactor binding
D5125_RS00100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5125_RS00115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D5125_RS00130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5125_RS00130	COG2111	Na H antiporter
D5125_RS00135	COG1006	Multisubunit Na H antiporter MnhC subunit
D5125_RS00140	COG0651	ATP synthesis coupled electron transport
D5125_RS00145	COG1863	multisubunit Na H antiporter MnhE subunit
D5125_RS00150	COG2212	antiporter activity
D5125_RS00155	COG1320	monovalent cation:proton antiporter activity
D5125_RS00160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5125_RS00165	COG2863	cytochrome
D5125_RS00175	COG3850	Histidine kinase
D5125_RS00175	COG3437	response regulator, receiver
D5125_RS00175	COG4999	Histidine kinase
D5125_RS00175	COG2205	protein histidine kinase activity
D5125_RS00215	COG2223	nitrite transmembrane transporter activity
D5125_RS00235	COG1269	ATP hydrolysis coupled proton transport
D5125_RS00250	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
D5125_RS00255	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D5125_RS00260	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
D5125_RS00270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5125_RS00275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5125_RS00280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D5125_RS00290	COG1420	regulation of RNA biosynthetic process
D5125_RS00295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5125_RS00300	COG0497	DNA recombination
D5125_RS00320	COG1007	ATP synthesis coupled electron transport
D5125_RS00335	COG0713	ATP synthesis coupled electron transport
D5125_RS00345	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5125_RS00350	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D5125_RS00355	COG1034	ATP synthesis coupled electron transport
D5125_RS00365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D5125_RS00370	COG0649	NAD binding
D5125_RS00375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5125_RS00380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5125_RS00385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5125_RS00390	COG2226	methyltransferase
D5125_RS00395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5125_RS00420	COG2111	Na H antiporter
D5125_RS00420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5125_RS00435	COG2111	Na H antiporter
D5125_RS00440	COG1006	Multisubunit Na H antiporter MnhC subunit
D5125_RS00445	COG0651	ATP synthesis coupled electron transport
D5125_RS00450	COG1863	multisubunit Na H antiporter MnhE subunit
D5125_RS00455	COG2212	antiporter activity
D5125_RS00495	COG0649	NAD binding
D5125_RS00500	COG0649	NAD binding
D5125_RS00500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5125_RS00510	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D5125_RS00520	COG0651	ATP synthesis coupled electron transport
D5125_RS00525	COG1006	Multisubunit Na H antiporter MnhC subunit
D5125_RS00530	COG2111	Na H antiporter
D5125_RS00545	COG2212	antiporter activity
D5125_RS00550	COG1863	multisubunit Na H antiporter MnhE subunit
D5125_RS00560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5125_RS00580	COG2171	N-acyltransferase activity
D5125_RS00595	COG0700	Nucleoside recognition
D5125_RS00600	COG0791	NLP P60 protein
D5125_RS00605	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D5125_RS00680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5125_RS00690	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D5125_RS00695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5125_RS00700	COG3122	Protein conserved in bacteria
D5125_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
D5125_RS00720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5125_RS00725	COG1473	amidohydrolase
D5125_RS00735	COG4953	penicillin-binding protein 1C
D5125_RS00740	COG2373	Large extracellular alpha-helical protein
D5125_RS00760	COG0601	transmembrane transport
D5125_RS00775	COG0217	transcriptional regulatory protein
D5125_RS00780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D5125_RS00785	COG0632	four-way junction helicase activity
D5125_RS00790	COG2255	four-way junction helicase activity
D5125_RS00795	COG0824	Thioesterase
D5125_RS00815	COG0823	Involved in the tonB-independent uptake of proteins
D5125_RS00835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D5125_RS00870	COG0564	pseudouridine synthase activity
D5125_RS00875	COG1530	ribonuclease E activity
D5125_RS00880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5125_RS00890	COG0745	RESPONSE REGULATOR receiver
D5125_RS00910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5125_RS00915	COG0085	RNA polymerase activity
D5125_RS00920	COG0222	ribosome binding
D5125_RS00925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5125_RS00930	COG0081	regulation of translation
D5125_RS00935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5125_RS00990	COG0193	aminoacyl-tRNA hydrolase activity
D5125_RS00995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5125_RS01000	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5125_RS01010	COG0358	DNA primase activity
D5125_RS01030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5125_RS01035	COG0316	Belongs to the HesB IscA family
D5125_RS01045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5125_RS01050	COG1981	membrane
D5125_RS01060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS01065	COG2326	polyphosphate kinase activity
D5125_RS01070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D5125_RS01075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5125_RS01080	COG3577	Aspartyl protease
D5125_RS01110	COG1487	ribonuclease activity
D5125_RS01145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5125_RS01165	COG0784	Response regulator, receiver
D5125_RS01165	COG5002	protein histidine kinase activity
D5125_RS01165	COG2205	protein histidine kinase activity
D5125_RS01175	COG3437	response regulator, receiver
D5125_RS01195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5125_RS01200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5125_RS01205	COG0517	IMP dehydrogenase activity
D5125_RS01205	COG0516	GMP reductase activity
D5125_RS01210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5125_RS01235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5125_RS01245	COG0666	response to abiotic stimulus
D5125_RS01265	COG0583	DNA-binding transcription factor activity
D5125_RS01280	COG0537	adenosine 5'-monophosphoramidase activity
D5125_RS01290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5125_RS01305	COG3876	Protein conserved in bacteria
D5125_RS01320	COG1162	GTPase activity
D5125_RS01335	COG0514	ATP-dependent DNA helicase (RecQ)
D5125_RS01340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5125_RS01345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5125_RS01360	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D5125_RS01365	COG1194	a g-specific adenine glycosylase
D5125_RS01370	COG0837	glucose binding
D5125_RS01395	COG2212	antiporter activity
D5125_RS01410	COG1006	Multisubunit Na H antiporter MnhC subunit
D5125_RS01415	COG0651	ATP synthesis coupled electron transport
D5125_RS01420	COG0651	ATP synthesis coupled electron transport
D5125_RS01430	COG0651	ATP synthesis coupled electron transport
D5125_RS01440	COG3954	Phosphoribulokinase
D5125_RS01450	COG0483	inositol monophosphate 1-phosphatase activity
D5125_RS01455	COG0741	lytic transglycosylase activity
D5125_RS01470	COG2201	protein-glutamate methylesterase activity
D5125_RS01485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5125_RS01490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5125_RS01495	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D5125_RS01505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5125_RS01510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5125_RS01515	COG0505	Belongs to the CarA family
D5125_RS01520	COG0514	ATP-dependent DNA helicase (RecQ)
D5125_RS01540	COG1917	Cupin 2, conserved barrel domain protein
D5125_RS01545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5125_RS01550	COG0456	acetyltransferase
D5125_RS01560	COG1192	Involved in chromosome partitioning
D5125_RS01565	COG2201	protein-glutamate methylesterase activity
D5125_RS01570	COG2198	Histidine kinase
D5125_RS01570	COG0784	Response regulator, receiver
D5125_RS01570	COG0643	Histidine kinase
D5125_RS01605	COG4269	membrane
D5125_RS01620	COG1987	bacterial-type flagellum assembly
D5125_RS01655	COG0215	cysteine-tRNA ligase activity
D5125_RS01670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5125_RS01675	COG3108	Peptidase M15
D5125_RS01680	COG2989	Protein conserved in bacteria
D5125_RS01690	COG1686	Belongs to the peptidase S11 family
D5125_RS01705	COG0583	DNA-binding transcription factor activity
D5125_RS01710	COG1049	propionate catabolic process, 2-methylcitrate cycle
D5125_RS01725	COG1122	ATPase activity
D5125_RS01765	COG1999	signal sequence binding
D5125_RS01780	COG2010	Cytochrome c
D5125_RS01790	COG4115	mRNA cleavage
D5125_RS01815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5125_RS01815	COG1648	precorrin-2 dehydrogenase activity
D5125_RS01825	COG3391	amine dehydrogenase activity
D5125_RS01845	COG0535	radical SAM domain protein
D5125_RS01855	COG2010	Cytochrome c
D5125_RS01875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5125_RS01885	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5125_RS01890	COG0569	domain protein
D5125_RS01895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5125_RS01905	COG2205	protein histidine kinase activity
D5125_RS01910	COG0745	RESPONSE REGULATOR receiver
D5125_RS01950	COG2226	methyltransferase
D5125_RS01955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5125_RS01970	COG1104	cysteine desulfurase activity
D5125_RS01985	COG1140	nitrate reductase beta subunit
D5125_RS01990	COG0243	molybdopterin cofactor binding
D5125_RS02000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5125_RS02015	COG0730	response to heat
D5125_RS02065	COG0142	geranyltranstransferase activity
D5125_RS02070	COG1469	GTP cyclohydrolase I activity
D5125_RS02080	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5125_RS02085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D5125_RS02095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5125_RS02100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5125_RS02115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5125_RS02115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5125_RS02125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5125_RS02130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5125_RS02140	COG0784	Response regulator, receiver
D5125_RS02140	COG5002	protein histidine kinase activity
D5125_RS02140	COG2205	protein histidine kinase activity
D5125_RS02150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D5125_RS02160	COG0359	binds to the 23S rRNA
D5125_RS02175	COG0360	Binds together with S18 to 16S ribosomal RNA
D5125_RS02180	COG1538	Outer membrane efflux protein
D5125_RS02185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5125_RS02205	COG3041	Addiction module toxin RelE StbE family
D5125_RS02210	COG3077	Addiction module antitoxin, RelB DinJ family
D5125_RS02215	COG0582	viral genome integration into host DNA
D5125_RS02225	COG0457	Tetratricopeptide repeat
D5125_RS02230	COG3385	transposase activity
D5125_RS02255	COG2027	D-alanyl-D-alanine carboxypeptidase
D5125_RS02260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5125_RS02265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D5125_RS02270	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5125_RS02275	COG1324	tolerance protein
D5125_RS02280	COG4232	protein-disulfide reductase activity
D5125_RS02285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5125_RS02290	COG0424	maF-like protein
D5125_RS02295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5125_RS02300	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D5125_RS02305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5125_RS02315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5125_RS02325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D5125_RS02350	COG1573	uracil-dna glycosylase
D5125_RS02355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5125_RS02360	COG4251	negative regulation of phosphorylation
D5125_RS02365	COG5007	Belongs to the BolA IbaG family
D5125_RS02370	COG0840	transmembrane signaling receptor activity
D5125_RS02385	COG2920	part of a sulfur-relay system
D5125_RS02410	COG3118	belongs to the thioredoxin family
D5125_RS02415	COG1720	tRNA m6t6A37 methyltransferase activity
D5125_RS02455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5125_RS02460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5125_RS02465	COG1862	Preprotein translocase
D5125_RS02475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5125_RS02480	COG3706	GGDEF domain
D5125_RS02490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5125_RS02515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5125_RS02520	COG2703	oxygen carrier activity
D5125_RS02540	COG1199	ATP-dependent helicase activity
D5125_RS02555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5125_RS02580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5125_RS02590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5125_RS02595	COG3278	Belongs to the heme-copper respiratory oxidase family
D5125_RS02610	COG2010	Cytochrome c
D5125_RS02615	COG0348	domain, Protein
D5125_RS02690	COG3668	Plasmid stabilization system
D5125_RS02730	COG1690	Belongs to the RtcB family
D5125_RS02735	COG3541	Predicted nucleotidyltransferase
D5125_RS02845	COG0629	single-stranded DNA binding
D5125_RS02890	COG3122	Protein conserved in bacteria
D5125_RS03005	COG2181	nitrate reductase activity
D5125_RS03030	COG4251	negative regulation of phosphorylation
D5125_RS03030	COG5001	Diguanylate cyclase
D5125_RS03030	COG3706	GGDEF domain
D5125_RS03030	COG2203	Gaf domain
D5125_RS03035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5125_RS03035	COG2205	protein histidine kinase activity
D5125_RS03060	COG0243	molybdopterin cofactor binding
D5125_RS03070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D5125_RS03075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5125_RS03080	COG0312	modulator of DNA gyrase
D5125_RS03085	COG0312	modulator of DNA gyrase
D5125_RS03120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5125_RS03125	COG0739	heme binding
D5125_RS03130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D5125_RS03135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5125_RS03150	COG0543	2 iron, 2 sulfur cluster binding
D5125_RS03160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5125_RS03200	COG1872	DUF167
D5125_RS03210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5125_RS03215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5125_RS03220	COG2003	Belongs to the UPF0758 family
D5125_RS03225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5125_RS03230	COG0756	dUTP diphosphatase activity
D5125_RS03235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5125_RS03265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D5125_RS03280	COG0194	GDP metabolic process
D5125_RS03285	COG1763	Mo-molybdopterin cofactor biosynthetic process
D5125_RS03295	COG3043	anaerobic respiration
D5125_RS03300	COG0348	domain, Protein
D5125_RS03305	COG0437	4 iron, 4 sulfur cluster binding
D5125_RS03310	COG0243	molybdopterin cofactor binding
D5125_RS03320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5125_RS03355	COG0730	response to heat
D5125_RS03375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5125_RS03380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5125_RS03385	COG0140	phosphoribosyl-ATP diphosphatase activity
D5125_RS03390	COG2003	Belongs to the UPF0758 family
D5125_RS03400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5125_RS03455	COG0107	imidazoleglycerol-phosphate synthase activity
D5125_RS03460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5125_RS03465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5125_RS03470	COG0131	Imidazoleglycerol-phosphate dehydratase
D5125_RS03475	COG1490	D-aminoacyl-tRNA deacylase activity
D5125_RS03480	COG1217	gtp-binding protein TYPA
D5125_RS03485	COG0330	HflC and HflK could
D5125_RS03505	COG0268	Binds directly to 16S ribosomal RNA
D5125_RS03515	COG0189	ligase activity
D5125_RS03530	COG0784	Response regulator, receiver
D5125_RS03530	COG2205	protein histidine kinase activity
D5125_RS03530	COG2198	Histidine kinase
D5125_RS03535	COG4660	Part of a membrane complex involved in electron transport
D5125_RS03555	COG2878	Part of a membrane complex involved in electron transport
D5125_RS03560	COG4657	Part of a membrane complex involved in electron transport
D5125_RS03575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5125_RS03600	COG4175	Glycine betaine
D5125_RS03605	COG4176	ABC-type proline glycine betaine transport system permease component
D5125_RS03610	COG2113	Glycine betaine
D5125_RS03635	COG1028	Short-chain dehydrogenase reductase Sdr
D5125_RS03640	COG0318	PFAM AMP-dependent synthetase and ligase
D5125_RS03665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5125_RS03715	COG0535	radical SAM domain protein
D5125_RS03720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5125_RS03725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5125_RS03740	COG0275	rRNA processing
D5125_RS03800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5125_RS03840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS03845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5125_RS03865	COG3385	transposase activity
D5125_RS03900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D5125_RS03905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5125_RS03915	COG2089	acid synthase
D5125_RS03920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5125_RS04055	COG4636	protein conserved in cyanobacteria
D5125_RS04060	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D5125_RS04065	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D5125_RS04070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5125_RS04090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5125_RS04095	COG2089	acid synthase
D5125_RS04135	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D5125_RS04150	COG0735	belongs to the Fur family
D5125_RS04155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5125_RS04165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5125_RS04170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5125_RS04175	COG0784	Response regulator, receiver
D5125_RS04175	COG2198	Histidine kinase
D5125_RS04175	COG5002	protein histidine kinase activity
D5125_RS04190	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5125_RS04195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D5125_RS04200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5125_RS04215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5125_RS04220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5125_RS04230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D5125_RS04235	COG0010	Belongs to the arginase family
D5125_RS04240	COG4251	negative regulation of phosphorylation
D5125_RS04240	COG2203	Gaf domain
D5125_RS04240	COG3706	GGDEF domain
D5125_RS04240	COG5001	Diguanylate cyclase
D5125_RS04250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5125_RS04255	COG0525	valine-tRNA ligase activity
D5125_RS04260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D5125_RS04265	COG0848	biopolymer transport protein
D5125_RS04270	COG0811	peptide transport
D5125_RS04275	COG0811	peptide transport
D5125_RS04280	COG0084	hydrolase, TatD family'
D5125_RS04340	COG1253	flavin adenine dinucleotide binding
D5125_RS04355	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5125_RS04370	COG0840	transmembrane signaling receptor activity
D5125_RS04385	COG2198	Histidine kinase
D5125_RS04385	COG0643	Histidine kinase
D5125_RS04390	COG0840	transmembrane signaling receptor activity
D5125_RS04395	COG0835	chemotaxis
D5125_RS04400	COG0840	transmembrane signaling receptor activity
D5125_RS04410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5125_RS04415	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5125_RS04420	COG2201	protein-glutamate methylesterase activity
D5125_RS04425	COG0138	bifunctional purine biosynthesis protein purh
D5125_RS04430	COG0151	Belongs to the GarS family
D5125_RS04450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D5125_RS04455	COG0778	Nitroreductase
D5125_RS04465	COG2888	peptidyl-tyrosine sulfation
D5125_RS04475	COG0058	SHG alpha-glucan phosphorylase activity
D5125_RS04480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5125_RS04485	COG1598	PFAM Uncharacterised protein family UPF0150
D5125_RS04495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5125_RS04505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D5125_RS04525	COG3079	Belongs to the UPF0149 family
D5125_RS04530	COG0006	proline dipeptidase activity
D5125_RS04535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5125_RS04540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5125_RS04545	COG0714	Associated with various cellular activities
D5125_RS04550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS04590	COG2198	Histidine kinase
D5125_RS04590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5125_RS04590	COG0784	Response regulator, receiver
D5125_RS04590	COG2205	protein histidine kinase activity
D5125_RS04595	COG0745	RESPONSE REGULATOR receiver
D5125_RS04620	COG0457	Tetratricopeptide repeat
D5125_RS04635	COG1943	Transposase
D5125_RS04665	COG0543	2 iron, 2 sulfur cluster binding
D5125_RS04665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5125_RS04720	COG1047	Peptidyl-prolyl cis-trans
D5125_RS04745	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D5125_RS04755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D5125_RS04760	COG1137	ATPase activity
D5125_RS04765	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5125_RS04785	COG1660	Displays ATPase and GTPase activities
D5125_RS04790	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5125_RS04795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5125_RS04820	COG4181	ATPase activity
D5125_RS04835	COG0314	molybdopterin synthase activity
D5125_RS04840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5125_RS04855	COG3437	response regulator, receiver
D5125_RS04860	COG2205	protein histidine kinase activity
D5125_RS04860	COG5002	protein histidine kinase activity
D5125_RS04860	COG0784	Response regulator, receiver
D5125_RS04875	COG4636	protein conserved in cyanobacteria
D5125_RS04880	COG4636	protein conserved in cyanobacteria
D5125_RS04885	COG0708	Exodeoxyribonuclease III
D5125_RS04890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5125_RS04895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5125_RS04905	COG0330	HflC and HflK could
D5125_RS04910	COG0330	HflC and HflK could
D5125_RS04915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5125_RS04920	COG1923	regulation of RNA biosynthetic process
D5125_RS04960	COG1611	Belongs to the LOG family
D5125_RS04965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5125_RS04995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D5125_RS05010	COG0628	permease
D5125_RS05015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5125_RS05025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5125_RS05030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5125_RS05040	COG0725	ABC transporter, periplasmic molybdate-binding protein
D5125_RS05045	COG0717	Belongs to the dCTP deaminase family
D5125_RS05095	COG0438	transferase activity, transferring glycosyl groups
D5125_RS05100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS05115	COG0463	Glycosyl transferase, family 2
D5125_RS05125	COG1132	(ABC) transporter
D5125_RS05145	COG1160	GTP binding
D5125_RS05155	COG2976	Protein conserved in bacteria
D5125_RS05160	COG0124	histidyl-tRNA synthetase
D5125_RS05175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5125_RS05180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5125_RS05195	COG0633	Ferredoxin
D5125_RS05200	COG0443	Heat shock 70 kDa protein
D5125_RS05215	COG0822	iron-sulfur transferase activity
D5125_RS05220	COG1104	cysteine desulfurase activity
D5125_RS05225	COG1959	2 iron, 2 sulfur cluster binding
D5125_RS05235	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D5125_RS05255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5125_RS05260	COG0564	pseudouridine synthase activity
D5125_RS05265	COG2862	Uncharacterized protein family, UPF0114
D5125_RS05285	COG0840	transmembrane signaling receptor activity
D5125_RS05290	COG2989	Protein conserved in bacteria
D5125_RS05325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5125_RS05330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5125_RS05335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D5125_RS05345	COG3437	response regulator, receiver
D5125_RS05355	COG1393	Belongs to the ArsC family
D5125_RS05375	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5125_RS05380	COG3657	addiction module killer protein
D5125_RS05395	COG3344	reverse transcriptase
D5125_RS05415	COG0457	Tetratricopeptide repeat
D5125_RS05430	COG3344	reverse transcriptase
D5125_RS05450	COG3609	addiction module antidote protein, CC2985 family
D5125_RS05505	COG0457	Tetratricopeptide repeat
D5125_RS05555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS05625	COG0438	transferase activity, transferring glycosyl groups
D5125_RS05625	COG1216	Glycosyl transferase, family 2
D5125_RS05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5125_RS05650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5125_RS05655	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5125_RS05660	COG2863	cytochrome
D5125_RS05665	COG3005	denitrification pathway
D5125_RS05670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D5125_RS05675	COG4206	TonB-dependent receptor
D5125_RS05680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5125_RS05690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5125_RS05700	COG0546	phosphoglycolate phosphatase activity
D5125_RS05705	COG2815	serine threonine protein kinase
D5125_RS05705	COG0515	serine threonine protein kinase
D5125_RS05715	COG0037	tRNA processing
D5125_RS05725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5125_RS05730	COG1999	signal sequence binding
D5125_RS05755	COG0181	hydroxymethylbilane synthase activity
D5125_RS05765	COG2972	Histidine kinase
D5125_RS05765	COG0745	RESPONSE REGULATOR receiver
D5125_RS05770	COG0165	Argininosuccinate lyase
D5125_RS05785	COG0019	diaminopimelate decarboxylase activity
D5125_RS05795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5125_RS05800	COG3159	Protein conserved in bacteria
D5125_RS05805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D5125_RS05810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5125_RS05855	COG4771	TonB-dependent receptor
D5125_RS05865	COG4771	TonB-dependent receptor
D5125_RS05880	COG0196	riboflavin kinase activity
D5125_RS05885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D5125_RS05895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5125_RS05895	COG2205	protein histidine kinase activity
D5125_RS05905	COG0142	geranyltranstransferase activity
D5125_RS05915	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D5125_RS05920	COG3668	Plasmid stabilization system
D5125_RS05925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5125_RS05955	COG3385	transposase activity
D5125_RS05965	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D5125_RS05985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5125_RS05990	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D5125_RS06000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5125_RS06005	COG0750	zinc metalloprotease
D5125_RS06015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5125_RS06025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5125_RS06030	COG0233	cytoplasmic translational termination
D5125_RS06040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5125_RS06045	COG0052	Belongs to the universal ribosomal protein uS2 family
D5125_RS06050	COG0024	Methionine aminopeptidase
D5125_RS06055	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D5125_RS06065	COG0563	adenylate kinase activity
D5125_RS06070	COG1183	phosphatidylcholine synthase activity
D5125_RS06075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5125_RS06080	COG0440	acetolactate synthase activity
D5125_RS06085	COG0028	Belongs to the TPP enzyme family
D5125_RS06090	COG0012	GTP binding
D5125_RS06105	COG0840	transmembrane signaling receptor activity
D5125_RS06115	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5125_RS06135	COG1192	Involved in chromosome partitioning
D5125_RS06145	COG0840	transmembrane signaling receptor activity
D5125_RS06150	COG0835	chemotaxis
D5125_RS06155	COG0643	Histidine kinase
D5125_RS06155	COG2198	Histidine kinase
D5125_RS06160	COG0745	RESPONSE REGULATOR receiver
D5125_RS06165	COG0513	Belongs to the DEAD box helicase family
D5125_RS06170	COG2925	Exonuclease
D5125_RS06185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5125_RS06190	COG1518	maintenance of DNA repeat elements
D5125_RS06225	COG1857	crispr-associated protein
D5125_RS06240	COG1203	CRISPR-associated helicase, Cas3
D5125_RS06245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D5125_RS06250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5125_RS06255	COG1053	succinate dehydrogenase
D5125_RS06270	COG0281	malic enzyme
D5125_RS06270	COG0280	phosphate acetyltransferase
D5125_RS06280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D5125_RS06285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D5125_RS06290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D5125_RS06295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D5125_RS06305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5125_RS06315	COG0586	Pfam SNARE associated Golgi protein
D5125_RS06320	COG0745	RESPONSE REGULATOR receiver
D5125_RS06325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5125_RS06330	COG0352	thiamine-phosphate diphosphorylase activity
D5125_RS06335	COG0351	phosphomethylpyrimidine kinase
D5125_RS06365	COG0784	Response regulator, receiver
D5125_RS06365	COG2198	Histidine kinase
D5125_RS06365	COG2205	protein histidine kinase activity
D5125_RS06385	COG5002	protein histidine kinase activity
D5125_RS06385	COG5001	Diguanylate cyclase
D5125_RS06395	COG0442	prolyl-tRNA aminoacylation
D5125_RS06400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5125_RS06410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D5125_RS06425	COG2264	protein methyltransferase activity
D5125_RS06430	COG0439	Biotin carboxylase
D5125_RS06435	COG0511	ligase activity, forming carbon-carbon bonds
D5125_RS06440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5125_RS06465	COG0205	6-phosphofructokinase activity
D5125_RS06470	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D5125_RS06480	COG0606	chelatase, subunit chli
D5125_RS06485	COG2960	long-chain fatty acid transporting porin activity
D5125_RS06490	COG0347	Belongs to the P(II) protein family
D5125_RS06495	COG0004	ammonium transporteR
D5125_RS06505	COG1858	cytochrome C peroxidase
D5125_RS06545	COG1305	Transglutaminase-like
D5125_RS06565	COG0730	response to heat
D5125_RS06565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5125_RS06590	COG3842	ATPase activity
D5125_RS06600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5125_RS06610	COG0069	glutamate synthase activity
D5125_RS06610	COG0067	glutamate synthase
D5125_RS06610	COG0070	glutamate synthase
D5125_RS06635	COG3177	Filamentation induced by cAMP protein fic
D5125_RS06675	COG4251	negative regulation of phosphorylation
D5125_RS06715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D5125_RS06720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5125_RS06735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D5125_RS06740	COG3383	formate dehydrogenase (NAD+) activity
D5125_RS06745	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
D5125_RS06750	COG3259	Nickel-dependent hydrogenase
D5125_RS06760	COG3706	GGDEF domain
D5125_RS06765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5125_RS06770	COG3001	Fructosamine kinase
D5125_RS06795	COG0386	Belongs to the glutathione peroxidase family
D5125_RS06810	COG0789	Transcriptional regulator
D5125_RS06815	COG0415	Belongs to the DNA photolyase family
D5125_RS06820	COG2358	TRAP transporter, solute receptor (TAXI family
D5125_RS06840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D5125_RS06845	COG3161	chorismate lyase activity
D5125_RS06850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5125_RS06855	COG0432	Pfam Uncharacterised protein family UPF0047
D5125_RS06865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5125_RS06870	COG1758	RNA polymerase activity
D5125_RS06875	COG1560	Kdo2-lipid A biosynthetic process
D5125_RS06880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D5125_RS06900	COG0438	transferase activity, transferring glycosyl groups
D5125_RS06920	COG0045	succinate-CoA ligase (ADP-forming) activity
D5125_RS06955	COG0309	Hydrogenase expression formation protein (HypE)
D5125_RS06970	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5125_RS06990	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5125_RS06995	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D5125_RS07000	COG5557	Pfam Polysulphide reductase, NrfD
D5125_RS07005	COG0437	4 iron, 4 sulfur cluster binding
D5125_RS07010	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D5125_RS07015	COG2204	response regulator
D5125_RS07020	COG0375	protein maturation
D5125_RS07035	COG0730	response to heat
D5125_RS07045	COG1051	belongs to the nudix hydrolase family
D5125_RS07050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5125_RS07055	COG0653	protein targeting
D5125_RS07065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D5125_RS07070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5125_RS07080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5125_RS07085	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5125_RS07090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5125_RS07100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5125_RS07105	COG0772	Belongs to the SEDS family
D5125_RS07110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5125_RS07115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5125_RS07120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5125_RS07125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5125_RS07135	COG3116	cell division
D5125_RS07140	COG0275	rRNA processing
D5125_RS07145	COG2001	Belongs to the MraZ family
D5125_RS07170	COG0316	Belongs to the HesB IscA family
D5125_RS07190	COG1047	Peptidyl-prolyl cis-trans
D5125_RS07195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5125_RS07200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5125_RS07210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5125_RS07215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5125_RS07220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5125_RS07230	COG0356	it plays a direct role in the translocation of protons across the membrane
D5125_RS07240	COG1475	DNA binding
D5125_RS07245	COG1192	Involved in chromosome partitioning
D5125_RS07260	COG0445	tRNA wobble uridine modification
D5125_RS07265	COG0714	Associated with various cellular activities
D5125_RS07280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5125_RS07285	COG0706	membrane insertase activity
D5125_RS07290	COG0594	ribonuclease P activity
D5125_RS07295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D5125_RS07310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5125_RS07315	COG0187	DNA topoisomerase II activity
D5125_RS07330	COG0752	glycyl-tRNA synthetase alpha subunit
D5125_RS07335	COG0482	sulfurtransferase activity
D5125_RS07350	COG0174	glutamine synthetase
D5125_RS07360	COG3852	Histidine kinase
D5125_RS07365	COG2204	response regulator
D5125_RS07380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5125_RS07390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5125_RS07395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5125_RS07400	COG1678	Uncharacterized ACR, COG1678
D5125_RS07410	COG1519	Transferase
D5125_RS07415	COG0363	glucosamine-6-phosphate deaminase activity
D5125_RS07430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5125_RS07430	COG3153	acetyltransferase
D5125_RS07435	COG1166	arginine decarboxylase activity
D5125_RS07450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5125_RS07455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5125_RS07460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5125_RS07475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D5125_RS07480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5125_RS07485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5125_RS07490	COG1136	(ABC) transporter
D5125_RS07540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5125_RS07545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D5125_RS07550	COG1127	ABC transporter
D5125_RS07555	COG1115	amino acid carrier protein
D5125_RS07590	COG3385	transposase activity
D5125_RS07620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5125_RS07635	COG0701	Predicted permease
D5125_RS07640	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D5125_RS07650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D5125_RS07670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5125_RS07675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D5125_RS07680	COG1428	Deoxynucleoside kinase
D5125_RS07685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5125_RS07690	COG0617	tRNA 3'-terminal CCA addition
D5125_RS07720	COG3744	PilT protein domain protein
D5125_RS07730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5125_RS07740	COG1573	uracil-dna glycosylase
D5125_RS07745	COG2197	response regulator
D5125_RS07760	COG0488	(ABC) transporter
D5125_RS07765	COG0322	excinuclease ABC activity
D5125_RS07790	COG3437	response regulator, receiver
D5125_RS07800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D5125_RS07805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5125_RS07810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5125_RS07820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5125_RS07825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5125_RS07830	COG0270	DNA (cytosine-5-)-methyltransferase activity
D5125_RS07880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5125_RS07935	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5125_RS07955	COG2853	Lipoprotein
D5125_RS07965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D5125_RS07975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5125_RS07980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5125_RS07990	COG2922	Belongs to the Smg family
D5125_RS07995	COG0758	DNA mediated transformation
D5125_RS08005	COG0242	peptide deformylase activity
D5125_RS08010	COG0745	RESPONSE REGULATOR receiver
D5125_RS08030	COG2900	Belongs to the SlyX family
D5125_RS08050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5125_RS08055	COG1444	tRNA N-acetyltransferase activity
D5125_RS08060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5125_RS08065	COG0189	ligase activity
D5125_RS08075	COG4067	protein conserved in archaea
D5125_RS08075	COG0189	ligase activity
D5125_RS08100	COG3604	Transcriptional regulator
D5125_RS08110	COG0494	nUDIX hydrolase
D5125_RS08120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5125_RS08125	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D5125_RS08160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5125_RS08165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5125_RS08170	COG0210	DNA helicase
D5125_RS08185	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D5125_RS08190	COG3385	transposase activity
D5125_RS08210	COG0589	response to stress
D5125_RS08215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D5125_RS08220	COG1074	ATP-dependent DNA helicase activity
D5125_RS08225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5125_RS08235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5125_RS08240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5125_RS08265	COG3318	Belongs to the UPF0149 family
D5125_RS08265	COG3012	SEC-C Motif Domain Protein
D5125_RS08270	COG0433	COG0433 Predicted ATPase
D5125_RS08280	COG2198	Histidine kinase
D5125_RS08280	COG0643	Histidine kinase
D5125_RS08280	COG0784	Response regulator, receiver
D5125_RS08290	COG0840	transmembrane signaling receptor activity
D5125_RS08295	COG0835	chemotaxis
D5125_RS08325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5125_RS08330	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5125_RS08370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5125_RS08375	COG0596	Alpha beta hydrolase
D5125_RS08385	COG0137	argininosuccinate synthase activity
D5125_RS08390	COG0439	Biotin carboxylase
D5125_RS08395	COG5016	pyruvate
D5125_RS08395	COG0511	ligase activity, forming carbon-carbon bonds
D5125_RS08400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5125_RS08445	COG0835	chemotaxis
D5125_RS08445	COG0784	Response regulator, receiver
D5125_RS08450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5125_RS08455	COG1815	bacterial-type flagellum-dependent cell motility
D5125_RS08470	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5125_RS08500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D5125_RS08505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5125_RS08515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5125_RS08520	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D5125_RS08530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D5125_RS08535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5125_RS08550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5125_RS08555	COG2813	Specifically methylates the guanine in position
D5125_RS08560	COG3706	GGDEF domain
D5125_RS08580	COG3474	cytochrome
D5125_RS08585	COG1858	cytochrome C peroxidase
D5125_RS08600	COG2010	Cytochrome c
D5125_RS08605	COG2703	oxygen carrier activity
D5125_RS08620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5125_RS08625	COG0154	amidase activity
D5125_RS08630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5125_RS08635	COG1077	Cell shape determining protein MreB Mrl
D5125_RS08650	COG0768	penicillin binding
D5125_RS08655	COG0772	Belongs to the SEDS family
D5125_RS08660	COG2951	lytic endotransglycosylase activity
D5125_RS08670	COG1686	Belongs to the peptidase S11 family
D5125_RS08680	COG2921	Belongs to the UPF0250 family
D5125_RS08685	COG0321	lipoyl(octanoyl) transferase activity
D5125_RS08690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D5125_RS08695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5125_RS08710	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5125_RS08715	COG0303	'Molybdopterin
D5125_RS08720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5125_RS08725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D5125_RS08735	COG0589	response to stress
D5125_RS08755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5125_RS08770	COG0436	Aminotransferase
D5125_RS08785	COG0228	four-way junction DNA binding
D5125_RS08790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5125_RS08795	COG0336	Belongs to the RNA methyltransferase TrmD family
D5125_RS08800	COG0335	large ribosomal subunit rRNA binding
D5125_RS08820	COG0723	plastoquinol--plastocyanin reductase activity
D5125_RS08825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5125_RS08830	COG2857	Cytochrome c1
D5125_RS08835	COG0625	glutathione transferase activity
D5125_RS08840	COG2969	positive regulation of protein catabolic process
D5125_RS08855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5125_RS08860	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5125_RS08865	COG0167	dihydroorotate dehydrogenase activity
D5125_RS08885	COG2217	Heavy metal translocating P-type atpase
D5125_RS08895	COG2226	methyltransferase
D5125_RS08900	COG2267	carboxylic ester hydrolase activity
D5125_RS08905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D5125_RS08915	COG2205	protein histidine kinase activity
D5125_RS08915	COG0784	Response regulator, receiver
D5125_RS08915	COG5002	protein histidine kinase activity
D5125_RS08920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D5125_RS08925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5125_RS08950	COG4804	nuclease activity
D5125_RS08975	COG0745	RESPONSE REGULATOR receiver
D5125_RS08980	COG0471	metal ion transport
D5125_RS08980	COG3273	potassium ion transport
D5125_RS08985	COG0583	DNA-binding transcription factor activity
D5125_RS09010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5125_RS09015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5125_RS09015	COG0730	response to heat
D5125_RS09025	COG1704	LemA family
D5125_RS09130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5125_RS09150	COG0667	Aldo Keto reductase
D5125_RS09180	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D5125_RS09195	COG0205	6-phosphofructokinase activity
D5125_RS09200	COG0488	(ABC) transporter
D5125_RS09215	COG0840	transmembrane signaling receptor activity
D5125_RS09220	COG2201	protein-glutamate methylesterase activity
D5125_RS09225	COG0457	Tetratricopeptide repeat
D5125_RS09225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5125_RS09235	COG2204	response regulator
D5125_RS09260	COG1484	DNA-dependent DNA replication
D5125_RS09265	COG4584	PFAM Integrase catalytic
D5125_RS09325	COG4974	Belongs to the 'phage' integrase family
D5125_RS09390	COG0436	Aminotransferase
D5125_RS09415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D5125_RS09425	COG0315	cyclic pyranopterin monophosphate synthase activity
D5125_RS09435	COG2161	toxin-antitoxin pair type II binding
D5125_RS09445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5125_RS09450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5125_RS09455	COG0126	phosphoglycerate kinase activity
D5125_RS09460	COG0469	pyruvate kinase activity
D5125_RS09465	COG0191	fructose-bisphosphate aldolase activity
D5125_RS09480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D5125_RS09500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5125_RS09505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5125_RS09510	COG0372	Belongs to the citrate synthase family
D5125_RS09515	COG0281	malic enzyme
D5125_RS09530	COG0254	rRNA binding
D5125_RS09535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5125_RS09540	COG0156	8-amino-7-oxononanoate synthase activity
D5125_RS09565	COG0750	zinc metalloprotease
D5125_RS09570	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D5125_RS09585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5125_RS09600	COG4636	protein conserved in cyanobacteria
D5125_RS09620	COG3385	transposase activity
D5125_RS09625	COG3668	Plasmid stabilization system
D5125_RS09640	COG3093	addiction module antidote protein HigA
D5125_RS09650	COG4969	Belongs to the N-Me-Phe pilin family
D5125_RS09685	COG3093	addiction module antidote protein HigA
D5125_RS09710	COG3045	CreA protein
D5125_RS09715	COG1570	exodeoxyribonuclease VII activity
D5125_RS09725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5125_RS09725	COG0519	Catalyzes the synthesis of GMP from XMP
D5125_RS09730	COG3549	Plasmid maintenance system killer
D5125_RS09760	COG3177	Filamentation induced by cAMP protein fic
D5125_RS09800	COG2920	part of a sulfur-relay system
D5125_RS09825	COG2221	Nitrite and sulphite reductase 4Fe-4S
D5125_RS09830	COG2221	Nitrite and sulphite reductase 4Fe-4S
D5125_RS09835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D5125_RS09840	COG2923	Belongs to the DsrF TusC family
D5125_RS09845	COG2168	tRNA wobble position uridine thiolation
D5125_RS09850	COG2920	part of a sulfur-relay system
D5125_RS09885	COG1797	cobyrinic acid a,c-diamide synthase activity
D5125_RS09915	COG1086	Polysaccharide biosynthesis protein
D5125_RS09925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5125_RS09930	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5125_RS09940	COG0742	ribosomal rna small subunit methyltransferase
D5125_RS09945	COG0612	Peptidase, M16
D5125_RS09950	COG0612	Peptidase, M16
D5125_RS09955	COG0552	protein localization to endoplasmic reticulum
D5125_RS09960	COG2884	Cell division ATP-binding protein ftsE
D5125_RS09965	COG2177	Part of the ABC transporter FtsEX involved in
D5125_RS09970	COG0840	transmembrane signaling receptor activity
D5125_RS09995	COG1484	DNA-dependent DNA replication
D5125_RS10000	COG4584	PFAM Integrase catalytic
D5125_RS10015	COG3586	endonuclease activity
D5125_RS10020	COG0732	type I restriction modification DNA specificity domain
D5125_RS10030	COG1850	ribulose-bisphosphate carboxylase activity
D5125_RS10035	COG4451	ribulose bisphosphate carboxylase, small
D5125_RS10060	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5125_RS10065	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5125_RS10085	COG0583	DNA-binding transcription factor activity
D5125_RS10090	COG0438	transferase activity, transferring glycosyl groups
D5125_RS10110	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D5125_RS10135	COG4636	protein conserved in cyanobacteria
D5125_RS10145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5125_RS10155	COG0517	IMP dehydrogenase activity
D5125_RS10170	COG1192	Involved in chromosome partitioning
D5125_RS10185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5125_RS10190	COG0280	phosphate acetyltransferase
D5125_RS10190	COG0857	belongs to the CobB CobQ family
D5125_RS10220	COG1278	Cold shock
D5125_RS10225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D5125_RS10230	COG0542	response to heat
D5125_RS10235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5125_RS10275	COG3220	belongs to the UPF0276 family
D5125_RS10285	COG2259	Doxx family
D5125_RS10290	COG3300	MHYT domain
D5125_RS10290	COG5001	Diguanylate cyclase
D5125_RS10300	COG0835	chemotaxis
D5125_RS10300	COG0784	Response regulator, receiver
D5125_RS10305	COG1509	lysine 2,3-aminomutase activity
D5125_RS10310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5125_RS10345	COG0688	phosphatidylethanolamine metabolic process
D5125_RS10390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5125_RS10400	COG1334	flagellar protein FlaG
D5125_RS10420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5125_RS10425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5125_RS10430	COG4636	protein conserved in cyanobacteria
D5125_RS10440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D5125_RS10440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5125_RS10450	COG0129	dihydroxy-acid dehydratase activity
D5125_RS10455	COG0527	aspartate kinase activity
D5125_RS10455	COG0460	homoserine dehydrogenase
D5125_RS10460	COG1115	amino acid carrier protein
D5125_RS10465	COG0668	transmembrane transport
D5125_RS10480	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5125_RS10485	COG3668	Plasmid stabilization system
D5125_RS10490	COG3609	addiction module antidote protein, CC2985 family
D5125_RS10495	COG0582	viral genome integration into host DNA
D5125_RS10570	COG2003	Belongs to the UPF0758 family
D5125_RS10580	COG0776	regulation of translation
D5125_RS10590	COG0670	Belongs to the BI1 family
D5125_RS10600	COG0724	RNA recognition motif
D5125_RS10605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5125_RS10615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5125_RS10640	COG0271	Belongs to the BolA IbaG family
D5125_RS10645	COG0405	Gamma-glutamyltransferase
D5125_RS10650	COG1671	Belongs to the UPF0178 family
D5125_RS10655	COG3118	belongs to the thioredoxin family
D5125_RS10680	COG2326	polyphosphate kinase activity
D5125_RS10685	COG1392	Phosphate transport regulator
D5125_RS10690	COG0306	phosphate transporter
D5125_RS10705	COG2198	Histidine kinase
D5125_RS10705	COG5002	protein histidine kinase activity
D5125_RS10705	COG0784	Response regulator, receiver
D5125_RS10715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5125_RS10720	COG0180	Tryptophanyl-tRNA synthetase
D5125_RS10725	COG1994	Peptidase M50
D5125_RS10730	COG0009	L-threonylcarbamoyladenylate synthase
D5125_RS10735	COG0613	PHP domain protein
D5125_RS10745	COG1185	polyribonucleotide nucleotidyltransferase activity
D5125_RS10750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5125_RS10755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5125_RS10760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5125_RS10765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5125_RS10770	COG0195	Participates in both transcription termination and antitermination
D5125_RS10775	COG0779	Required for maturation of 30S ribosomal subunits
D5125_RS10785	COG2914	Belongs to the UPF0125 (RnfH) family
D5125_RS10790	COG2867	negative regulation of translational initiation
D5125_RS10795	COG0733	neurotransmitter:sodium symporter activity
D5125_RS10800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5125_RS10810	COG0582	viral genome integration into host DNA
D5125_RS10815	COG0009	L-threonylcarbamoyladenylate synthase
D5125_RS10820	COG1994	Peptidase M50
D5125_RS10825	COG0180	Tryptophanyl-tRNA synthetase
D5125_RS10830	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5125_RS10840	COG2198	Histidine kinase
D5125_RS10840	COG5002	protein histidine kinase activity
D5125_RS10840	COG0784	Response regulator, receiver
D5125_RS10870	COG1943	Transposase
D5125_RS10895	COG2304	oxidoreductase activity
D5125_RS10915	COG0714	Associated with various cellular activities
D5125_RS10925	COG1845	cytochrome c oxidase, subunit III
D5125_RS10935	COG3118	belongs to the thioredoxin family
D5125_RS10940	COG3264	Mechanosensitive ion channel
D5125_RS10940	COG1196	nuclear chromosome segregation
D5125_RS10945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D5125_RS10950	COG1376	ErfK ybiS ycfS ynhG family protein
D5125_RS10970	COG2217	Heavy metal translocating P-type atpase
D5125_RS11030	COG1136	(ABC) transporter
D5125_RS11030	COG0577	efflux transmembrane transporter activity
D5125_RS11045	COG1902	pentaerythritol trinitrate reductase activity
D5125_RS11050	COG1083	cytidylyl-transferase
D5125_RS11065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5125_RS11105	COG0494	nUDIX hydrolase
D5125_RS11110	COG0463	Glycosyl transferase, family 2
D5125_RS11130	COG1011	Hydrolase
D5125_RS11135	COG0513	Belongs to the DEAD box helicase family
D5125_RS11145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5125_RS11165	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D5125_RS11170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5125_RS11175	COG0784	Response regulator, receiver
D5125_RS11175	COG2205	protein histidine kinase activity
D5125_RS11185	COG3437	response regulator, receiver
D5125_RS11195	COG0617	tRNA 3'-terminal CCA addition
D5125_RS11205	COG3850	Histidine kinase
D5125_RS11210	COG2197	response regulator
D5125_RS11215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5125_RS11230	COG0529	Catalyzes the synthesis of activated sulfate
D5125_RS11235	COG1218	3'(2'),5'-bisphosphate nucleotidase
D5125_RS11315	COG4584	PFAM Integrase catalytic
D5125_RS11320	COG1484	DNA-dependent DNA replication
D5125_RS11340	COG4115	mRNA cleavage
D5125_RS11385	COG2048	Heterodisulfide reductase, subunit B
D5125_RS11390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5125_RS11400	COG1233	COG1233 Phytoene dehydrogenase and related
D5125_RS11410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D5125_RS11415	COG0049	tRNA binding
D5125_RS11420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5125_RS11430	COG0051	transcription antitermination factor activity, RNA binding
D5125_RS11435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5125_RS11445	COG0089	rRNA binding
D5125_RS11450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D5125_RS11455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5125_RS11465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5125_RS11470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5125_RS11475	COG0255	Belongs to the universal ribosomal protein uL29 family
D5125_RS11480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5125_RS11485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5125_RS11490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D5125_RS11495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5125_RS11500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5125_RS11505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D5125_RS11510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5125_RS11515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D5125_RS11520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5125_RS11530	COG0200	Binds to the 23S rRNA
D5125_RS11535	COG0201	protein transport
D5125_RS11540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5125_RS11545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5125_RS11550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5125_RS11555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5125_RS11560	COG0202	RNA polymerase activity
D5125_RS11565	COG0203	ribosomal protein L17
D5125_RS11575	COG5001	Diguanylate cyclase
D5125_RS11585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5125_RS11590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5125_RS11600	COG0569	domain protein
D5125_RS11605	COG2204	response regulator
D5125_RS11610	COG5000	phosphorelay sensor kinase activity
D5125_RS11620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5125_RS11625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5125_RS11660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D5125_RS11665	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D5125_RS11670	COG0237	dephospho-CoA kinase activity
D5125_RS11675	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D5125_RS11690	COG0563	adenylate kinase activity
D5125_RS11725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5125_RS11730	COG4942	peptidase
D5125_RS11735	COG0793	Belongs to the peptidase S41A family
D5125_RS11740	COG2861	carbohydrate metabolic process
D5125_RS11745	COG0693	protein deglycase activity
D5125_RS11755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D5125_RS11755	COG1918	ferrous iron import across plasma membrane
D5125_RS11780	COG0495	leucyl-tRNA aminoacylation
D5125_RS11885	COG0540	Belongs to the ATCase OTCase family
D5125_RS11900	COG1691	(AIR) carboxylase
D5125_RS11910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5125_RS11915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D5125_RS11930	COG1561	YicC-like family, N-terminal region
D5125_RS11935	COG0582	viral genome integration into host DNA
D5125_RS11965	COG1484	DNA-dependent DNA replication
D5125_RS12025	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D5125_RS12065	COG1013	pyruvate-flavodoxin oxidoreductase activity
D5125_RS12065	COG0674	pyruvate-flavodoxin oxidoreductase activity
D5125_RS12065	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D5125_RS12065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D5125_RS12070	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D5125_RS12070	COG0493	'glutamate synthase
D5125_RS12115	COG1677	Flagellar hook-basal body complex protein FliE
D5125_RS12125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5125_RS12160	COG0328	RNA-DNA hybrid ribonuclease activity
D5125_RS12165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5125_RS12170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5125_RS12200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5125_RS12205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5125_RS12210	COG2137	regulation of response to DNA damage stimulus
D5125_RS12220	COG1489	DNA binding
D5125_RS12230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5125_RS12240	COG1136	(ABC) transporter
D5125_RS12245	COG0583	DNA-binding transcription factor activity
D5125_RS12250	COG1850	ribulose-bisphosphate carboxylase activity
D5125_RS12265	COG0300	oxidoreductase activity
D5125_RS12270	COG2183	response to ionizing radiation
D5125_RS12350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D5125_RS12355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D5125_RS12360	COG1238	metal cluster binding
D5125_RS12375	COG2204	response regulator
D5125_RS12380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5125_RS12405	COG4615	Cyclic peptide transporter
D5125_RS12415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5125_RS12420	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D5125_RS12425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5125_RS12430	COG2716	regulation of RNA biosynthetic process
D5125_RS12435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5125_RS12440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D5125_RS12455	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D5125_RS12460	COG0183	Belongs to the thiolase family
D5125_RS12470	COG3243	poly(R)-hydroxyalkanoic acid synthase
D5125_RS12475	COG0402	S-adenosylhomocysteine deaminase activity
D5125_RS12480	COG4536	flavin adenine dinucleotide binding
D5125_RS12485	COG0825	malonyl-CoA metabolic process
D5125_RS12490	COG0037	tRNA processing
D5125_RS12500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D5125_RS12510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5125_RS12530	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D5125_RS12535	COG0284	orotidine-5'-phosphate decarboxylase activity
D5125_RS12540	COG2046	Belongs to the sulfate adenylyltransferase family
D5125_RS12555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5125_RS12575	COG3321	synthase
D5125_RS12575	COG0604	alcohol dehydrogenase
D5125_RS12580	COG2192	nodulation
D5125_RS12590	COG0583	DNA-binding transcription factor activity
D5125_RS12595	COG2878	Part of a membrane complex involved in electron transport
D5125_RS12605	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D5125_RS12610	COG4656	Part of a membrane complex involved in electron transport
D5125_RS12615	COG4658	electron transport chain
D5125_RS12620	COG4659	FMN binding
D5125_RS12625	COG4660	Part of a membrane complex involved in electron transport
D5125_RS12630	COG4657	Part of a membrane complex involved in electron transport
D5125_RS12640	COG2814	Major facilitator Superfamily
D5125_RS12710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D5125_RS12730	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D5125_RS12735	COG1518	maintenance of DNA repeat elements
D5125_RS12745	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D5125_RS12760	COG0604	alcohol dehydrogenase
D5125_RS12775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5125_RS12780	COG2974	May be involved in recombination
D5125_RS12785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5125_RS12810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5125_RS12815	COG0066	3-isopropylmalate dehydratase activity
D5125_RS12820	COG0473	3-isopropylmalate dehydrogenase activity
D5125_RS12845	COG2200	EAL domain
D5125_RS12850	COG2205	protein histidine kinase activity
D5125_RS12850	COG0784	Response regulator, receiver
D5125_RS12850	COG5002	protein histidine kinase activity
D5125_RS12855	COG2201	protein-glutamate methylesterase activity
D5125_RS12965	COG5001	Diguanylate cyclase
D5125_RS12965	COG3300	MHYT domain
D5125_RS13005	COG2852	Protein conserved in bacteria
D5125_RS13020	COG0732	type I restriction modification DNA specificity domain
D5125_RS13045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D5125_RS13050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D5125_RS13050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D5125_RS13060	COG0509	glycine decarboxylation via glycine cleavage system
D5125_RS13065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5125_RS13085	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
D5125_RS13090	COG0659	secondary active sulfate transmembrane transporter activity
D5125_RS13095	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5125_RS13105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5125_RS13110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5125_RS13130	COG1196	nuclear chromosome segregation
D5125_RS13140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5125_RS13145	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5125_RS13155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D5125_RS13160	COG1706	bacterial-type flagellum-dependent cell motility
D5125_RS13170	COG4786	Flagellar basal body rod
D5125_RS13170	COG1256	bacterial-type flagellum assembly
D5125_RS13175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5125_RS13195	COG0326	Molecular chaperone. Has ATPase activity
D5125_RS13200	COG0546	phosphoglycolate phosphatase activity
D5125_RS13210	COG0745	RESPONSE REGULATOR receiver
D5125_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
D5125_RS13235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS13245	COG4133	protoheme IX ABC transporter activity
D5125_RS13250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D5125_RS13260	COG0659	secondary active sulfate transmembrane transporter activity
D5125_RS13285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5125_RS13290	COG3107	peptidoglycan biosynthetic process
D5125_RS13295	COG0792	nuclease activity
D5125_RS13300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D5125_RS13305	COG2823	Periplasmic or secreted lipoprotein
D5125_RS13310	COG0277	FAD linked oxidase domain protein
D5125_RS13315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5125_RS13320	COG1702	phosphate starvation-inducible protein PhoH
D5125_RS13325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5125_RS13330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D5125_RS13350	COG1355	regulation of microtubule-based process
D5125_RS13355	COG2078	PFAM AMMECR1 domain protein
D5125_RS13355	COG3885	ferrous iron binding
D5125_RS13365	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D5125_RS13370	COG1968	undecaprenyl-diphosphatase activity
D5125_RS13375	COG1648	precorrin-2 dehydrogenase activity
D5125_RS13375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5125_RS13380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5125_RS13385	COG0425	Belongs to the sulfur carrier protein TusA family
D5125_RS13390	COG2210	Belongs to the sulfur carrier protein TusA family
D5125_RS13415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D5125_RS13450	COG2205	protein histidine kinase activity
D5125_RS13450	COG5002	protein histidine kinase activity
D5125_RS13450	COG0784	Response regulator, receiver
D5125_RS13455	COG5001	Diguanylate cyclase
D5125_RS13455	COG5002	protein histidine kinase activity
D5125_RS13455	COG3447	MASE1 domain protein
D5125_RS13460	COG3437	response regulator, receiver
D5125_RS13480	COG0746	molybdenum cofactor guanylyltransferase activity
D5125_RS13490	COG3028	Belongs to the UPF0307 family
D5125_RS13505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5125_RS13535	COG1592	Rubrerythrin
D5125_RS13565	COG0494	nUDIX hydrolase
D5125_RS13580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5125_RS13600	COG2827	Endonuclease containing a URI domain
D5125_RS13605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5125_RS13610	COG0745	RESPONSE REGULATOR receiver
D5125_RS13620	COG5002	protein histidine kinase activity
D5125_RS13620	COG5001	Diguanylate cyclase
D5125_RS13640	COG0826	peptidase U32
D5125_RS13645	COG0826	peptidase U32
D5125_RS13650	COG3154	lipid carrier protein
D5125_RS13655	COG1242	4 iron, 4 sulfur cluster binding
D5125_RS13670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5125_RS13675	COG2176	DNA-directed DNA polymerase activity
D5125_RS13680	COG0517	IMP dehydrogenase activity
D5125_RS13680	COG0516	GMP reductase activity
D5125_RS13735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5125_RS13775	COG1346	cytolysis
D5125_RS13805	COG0811	peptide transport
D5125_RS13815	COG1663	tetraacyldisaccharide 4'-kinase activity
D5125_RS13820	COG2835	tetraacyldisaccharide 4'-kinase activity
D5125_RS13830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5125_RS13835	COG0573	inorganic phosphate transmembrane transporter activity
D5125_RS13845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5125_RS13855	COG2890	protein-(glutamine-N5) methyltransferase activity
D5125_RS13875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5125_RS13875	COG0301	tRNA thio-modification
D5125_RS13885	COG1595	DNA-templated transcription, initiation
D5125_RS13905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5125_RS13910	COG0481	GTPase activity
D5125_RS13925	COG0571	ribonuclease III activity
D5125_RS13930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5125_RS13935	COG1381	Involved in DNA repair and RecF pathway recombination
D5125_RS13940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D5125_RS13950	COG5002	protein histidine kinase activity
D5125_RS13950	COG5001	Diguanylate cyclase
D5125_RS13960	COG1509	lysine 2,3-aminomutase activity
D5125_RS13965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5125_RS13970	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D5125_RS14005	COG0795	lipopolysaccharide-transporting ATPase activity
D5125_RS14010	COG0795	lipopolysaccharide-transporting ATPase activity
D5125_RS14020	COG0242	peptide deformylase activity
D5125_RS14050	COG0542	response to heat
D5125_RS14065	COG0484	heat shock protein binding
D5125_RS14070	COG1090	epimerase
D5125_RS14080	COG2814	Major facilitator Superfamily
D5125_RS14100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5125_RS14100	COG1328	CTP reductase activity
D5125_RS14115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5125_RS14120	COG0135	phosphoribosylanthranilate isomerase activity
D5125_RS14125	COG0133	tryptophan synthase activity
D5125_RS14130	COG0159	tryptophan synthase activity
D5125_RS14135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5125_RS14145	COG1278	Cold shock
D5125_RS14150	COG0285	dihydrofolate synthase activity
D5125_RS14165	COG1286	toxin biosynthetic process
D5125_RS14200	COG0557	exoribonuclease II activity
D5125_RS14205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D5125_RS14210	COG4536	flavin adenine dinucleotide binding
D5125_RS14215	COG4536	flavin adenine dinucleotide binding
D5125_RS14220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5125_RS14230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5125_RS14240	COG0077	Prephenate dehydratase
D5125_RS14240	COG1605	Chorismate mutase
D5125_RS14255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5125_RS14270	COG4804	nuclease activity
D5125_RS14345	COG5002	protein histidine kinase activity
D5125_RS14345	COG0784	Response regulator, receiver
D5125_RS14360	COG0835	chemotaxis
D5125_RS14370	COG0513	Belongs to the DEAD box helicase family
D5125_RS14385	COG3005	denitrification pathway
D5125_RS14400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5125_RS14415	COG0084	hydrolase, TatD family'
D5125_RS14425	COG0492	ferredoxin-NADP+ reductase activity
D5125_RS14430	COG1674	ftsk spoiiie
D5125_RS14435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5125_RS14440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5125_RS14450	COG5265	(ABC) transporter
D5125_RS14460	COG3302	dmso reductase anchor subunit
D5125_RS14465	COG2091	lysine biosynthetic process via aminoadipic acid
D5125_RS14515	COG1959	2 iron, 2 sulfur cluster binding
D5125_RS14530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5125_RS14535	COG0424	maF-like protein
D5125_RS14545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5125_RS14550	COG0416	fatty acid biosynthetic process
D5125_RS14555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5125_RS14570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5125_RS14575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5125_RS14580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5125_RS14585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5125_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
D5125_RS14605	COG3347	Dehydrogenase
D5125_RS14615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5125_RS14620	COG1454	alcohol dehydrogenase
D5125_RS14665	COG1598	PFAM Uncharacterised protein family UPF0150
D5125_RS14775	COG1598	PFAM Uncharacterised protein family UPF0150
D5125_RS14830	COG3077	Addiction module antitoxin, RelB DinJ family
D5125_RS14925	COG1132	(ABC) transporter
D5125_RS15015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS15020	COG1088	dTDP-glucose 4,6-dehydratase activity
D5125_RS15045	COG2361	Protein of unknown function DUF86
D5125_RS15070	COG3609	addiction module antidote protein, CC2985 family
D5125_RS15085	COG3609	addiction module antidote protein, CC2985 family
D5125_RS15110	COG0438	transferase activity, transferring glycosyl groups
D5125_RS15115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5125_RS15120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5125_RS15125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D5125_RS15135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5125_RS15140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5125_RS15140	COG0072	phenylalanine-tRNA ligase activity
D5125_RS15145	COG0776	regulation of translation
D5125_RS15190	COG2995	paraquat-inducible protein a
D5125_RS15195	COG2995	paraquat-inducible protein a
D5125_RS15200	COG3008	intermembrane lipid transfer
D5125_RS15200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D5125_RS15205	COG0300	oxidoreductase activity
D5125_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
D5125_RS15205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5125_RS15205	COG3321	synthase
D5125_RS15205	COG0318	PFAM AMP-dependent synthetase and ligase
D5125_RS15210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5125_RS15210	COG0318	PFAM AMP-dependent synthetase and ligase
D5125_RS15210	COG0300	oxidoreductase activity
D5125_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
D5125_RS15210	COG3321	synthase
D5125_RS15245	COG0732	type I restriction modification DNA specificity domain
D5125_RS15305	COG3645	SOS response
D5125_RS15345	COG0420	3'-5' exonuclease activity
D5125_RS15350	COG0419	ATPase involved in DNA repair
D5125_RS15365	COG2423	ornithine cyclodeaminase activity
D5125_RS15375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5125_RS15385	COG1960	acyl-CoA dehydrogenase activity
D5125_RS15395	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5125_RS15425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D5125_RS15425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D5125_RS15430	COG0802	atpase or kinase
D5125_RS15435	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5125_RS15450	COG0574	Belongs to the PEP-utilizing enzyme family
D5125_RS15450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5125_RS15455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D5125_RS15475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5125_RS15490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5125_RS15495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5125_RS15505	COG2442	InterPro IPR007367
D5125_RS15510	COG1131	(ABC) transporter
D5125_RS15515	COG0842	Transport permease protein
D5125_RS15535	COG0561	phosphatase activity
D5125_RS15535	COG3100	YcgL domain-containing protein
D5125_RS15540	COG0438	transferase activity, transferring glycosyl groups
D5125_RS15555	COG0729	surface antigen
D5125_RS15575	COG1132	(ABC) transporter
D5125_RS15590	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D5125_RS15600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5125_RS15605	COG0287	Prephenate dehydrogenase
D5125_RS15610	COG0297	glycogen (starch) synthase activity
D5125_RS15615	COG2828	Protein conserved in bacteria
D5125_RS15620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5125_RS15625	COG0840	transmembrane signaling receptor activity
D5125_RS15630	COG0488	(ABC) transporter
D5125_RS15660	COG0714	Associated with various cellular activities
D5125_RS15680	COG2010	Cytochrome c
D5125_RS15715	COG0003	Pfam Anion-transporting ATPase
D5125_RS15725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5125_RS15730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5125_RS15735	COG0587	DNA-directed DNA polymerase activity
D5125_RS15745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5125_RS15750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5125_RS15800	COG2205	protein histidine kinase activity
D5125_RS15870	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5125_RS15875	COG0740	serine-type endopeptidase activity
D5125_RS15880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5125_RS15885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5125_RS15905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5125_RS15910	COG1832	CoA-binding protein
D5125_RS15915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5125_RS15925	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D5125_RS15940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5125_RS15945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5125_RS15950	COG0308	aminopeptidase N
D5125_RS15955	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5125_RS15970	COG2203	Gaf domain
D5125_RS15970	COG3706	GGDEF domain
D5125_RS15970	COG5001	Diguanylate cyclase
D5125_RS15970	COG4251	negative regulation of phosphorylation
D5125_RS15975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5125_RS15990	COG0776	regulation of translation
D5125_RS16000	COG4106	trans-aconitate 2-methyltransferase activity
D5125_RS16005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D5125_RS16015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5125_RS16030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5125_RS16040	COG1376	ErfK ybiS ycfS ynhG family protein
D5125_RS16050	COG1472	Belongs to the glycosyl hydrolase 3 family
D5125_RS16055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D5125_RS16060	COG0450	alkyl hydroperoxide reductase
D5125_RS16100	COG0501	Belongs to the peptidase M48B family
D5125_RS16120	COG0585	pseudouridine synthase activity
D5125_RS16175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5125_RS16180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D5125_RS16185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5125_RS16190	COG0148	phosphopyruvate hydratase activity
D5125_RS16195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D5125_RS16200	COG0504	CTP synthase activity
D5125_RS16205	COG0189	ligase activity
D5125_RS16210	COG0456	acetyltransferase
D5125_RS16225	COG0149	triose-phosphate isomerase activity
D5125_RS16240	COG1643	Atp-dependent helicase
D5125_RS16245	COG2873	o-acetylhomoserine
D5125_RS16250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5125_RS16270	COG4783	chaperone-mediated protein folding
D5125_RS16285	COG3258	Cytochrome c
D5125_RS16290	COG2010	Cytochrome c
D5125_RS16300	COG4251	negative regulation of phosphorylation
D5125_RS16305	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D5125_RS16320	COG0567	Dehydrogenase, E1 component
D5125_RS16325	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5125_RS16335	COG0735	belongs to the Fur family
D5125_RS16340	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D5125_RS16345	COG0071	Belongs to the small heat shock protein (HSP20) family
D5125_RS16355	COG0739	heme binding
D5125_RS16355	COG0741	lytic transglycosylase activity
D5125_RS16355	COG1196	nuclear chromosome segregation
D5125_RS16360	COG3012	SEC-C Motif Domain Protein
D5125_RS16375	COG0390	transport system, permease component
D5125_RS16380	COG4619	ABC transporter
D5125_RS16385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5125_RS16390	COG2022	thiamine diphosphate biosynthetic process
D5125_RS16400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5125_RS16420	COG1546	Belongs to the CinA family
D5125_RS16435	COG2917	probably involved in intracellular septation
D5125_RS16440	COG2350	Protein conserved in bacteria
D5125_RS16445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5125_RS16465	COG1643	Atp-dependent helicase
D5125_RS16490	COG0033	Phosphoglucomutase
D5125_RS16495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5125_RS16510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5125_RS16515	COG2983	Belongs to the UPF0260 family
D5125_RS16535	COG1028	Short-chain dehydrogenase reductase Sdr
D5125_RS16540	COG0045	succinate-CoA ligase (ADP-forming) activity
D5125_RS16540	COG1042	CoA-binding domain protein
D5125_RS16540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5125_RS16545	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5125_RS16590	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5125_RS16595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5125_RS16605	COG0247	lactate metabolic process
D5125_RS16610	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D5125_RS16615	COG1765	OsmC-like protein
D5125_RS16635	COG2116	formate transmembrane transporter activity
D5125_RS16645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5125_RS16660	COG3657	addiction module killer protein
D5125_RS16665	COG0134	indole-3-glycerol-phosphate synthase activity
D5125_RS16670	COG2304	oxidoreductase activity
D5125_RS16675	COG1595	DNA-templated transcription, initiation
D5125_RS16685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5125_RS16690	COG3093	addiction module antidote protein HigA
D5125_RS16700	COG0339	signal peptide processing
D5125_RS16715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5125_RS16725	COG0018	arginyl-trna synthetase
D5125_RS16745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5125_RS16755	COG0166	Belongs to the GPI family
D5125_RS16765	COG1187	pseudouridine synthase activity
D5125_RS16770	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5125_RS16775	COG2814	Major facilitator Superfamily
D5125_RS16785	COG3144	bacterial-type flagellum assembly
D5125_RS16790	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5125_RS16795	COG0484	heat shock protein binding
D5125_RS16800	COG0443	Heat shock 70 kDa protein
D5125_RS16805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5125_RS16815	COG1639	'signal transduction protein
D5125_RS16820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5125_RS16830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5125_RS16850	COG0826	peptidase U32
D5125_RS16865	COG0489	protein tyrosine kinase activity
D5125_RS16870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5125_RS16870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5125_RS16885	COG2119	membrane