locus-tag	class	description
GWK26_RS00005	COG0813	purine-nucleoside phosphorylase activity
GWK26_RS00010	COG1252	NADH dehydrogenase
GWK26_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GWK26_RS00030	COG0187	DNA topoisomerase II activity
GWK26_RS00055	COG0436	Aminotransferase
GWK26_RS00065	COG0436	Aminotransferase
GWK26_RS00070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GWK26_RS00075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK26_RS00090	COG1301	dicarboxylic acid transport
GWK26_RS00125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK26_RS00130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS00145	COG2267	carboxylic ester hydrolase activity
GWK26_RS00160	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWK26_RS00165	COG1121	(ABC) transporter
GWK26_RS00170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK26_RS00210	COG0318	PFAM AMP-dependent synthetase and ligase
GWK26_RS00220	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK26_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK26_RS00250	COG1058	Belongs to the CinA family
GWK26_RS00250	COG1546	Belongs to the CinA family
GWK26_RS00300	COG1131	(ABC) transporter
GWK26_RS00305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK26_RS00310	COG0346	lactoylglutathione lyase activity
GWK26_RS00325	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS00370	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS00375	COG1063	alcohol dehydrogenase
GWK26_RS00380	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS00390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GWK26_RS00395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GWK26_RS00415	COG0346	lactoylglutathione lyase activity
GWK26_RS00425	COG2337	Toxic component of a toxin-antitoxin (TA) module
GWK26_RS00455	COG0733	neurotransmitter:sodium symporter activity
GWK26_RS00505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK26_RS00520	COG0745	RESPONSE REGULATOR receiver
GWK26_RS00525	COG4191	Histidine kinase
GWK26_RS00545	COG2358	TRAP transporter, solute receptor (TAXI family
GWK26_RS00550	COG0589	response to stress
GWK26_RS00555	COG1832	CoA-binding protein
GWK26_RS00565	COG0596	Alpha beta hydrolase
GWK26_RS00575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK26_RS00650	COG0516	GMP reductase activity
GWK26_RS00650	COG0517	IMP dehydrogenase activity
GWK26_RS00655	COG0745	RESPONSE REGULATOR receiver
GWK26_RS00660	COG0668	transmembrane transport
GWK26_RS00680	COG1278	Cold shock
GWK26_RS00685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK26_RS00690	COG1254	Belongs to the acylphosphatase family
GWK26_RS00695	COG1201	RNA secondary structure unwinding
GWK26_RS00730	COG3118	belongs to the thioredoxin family
GWK26_RS00735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWK26_RS00735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK26_RS00740	COG0315	cyclic pyranopterin monophosphate synthase activity
GWK26_RS00745	COG3383	formate dehydrogenase (NAD+) activity
GWK26_RS00755	COG0306	phosphate transporter
GWK26_RS00800	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK26_RS00800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK26_RS00800	COG0649	NAD binding
GWK26_RS00825	COG2239	Acts as a magnesium transporter
GWK26_RS00855	COG1575	Belongs to the MenA family. Type 1 subfamily
GWK26_RS00860	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS00885	COG0589	response to stress
GWK26_RS00895	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK26_RS00915	COG0215	cysteine-tRNA ligase activity
GWK26_RS00945	COG2897	thiosulfate sulfurtransferase activity
GWK26_RS00960	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GWK26_RS00965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GWK26_RS00970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWK26_RS01005	COG0534	Mate efflux family protein
GWK26_RS01015	COG3119	arylsulfatase activity
GWK26_RS01035	COG0109	protoheme IX farnesyltransferase activity
GWK26_RS01055	COG1476	TRANSCRIPTIONal
GWK26_RS01075	COG5002	protein histidine kinase activity
GWK26_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS01090	COG0210	DNA helicase
GWK26_RS01180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK26_RS01200	COG0647	UMP catabolic process
GWK26_RS01210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK26_RS01215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK26_RS01225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWK26_RS01240	COG0133	tryptophan synthase activity
GWK26_RS01250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK26_RS01260	COG1278	Cold shock
GWK26_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
GWK26_RS01280	COG0604	alcohol dehydrogenase
GWK26_RS01280	COG3321	synthase
GWK26_RS01285	COG0402	S-adenosylhomocysteine deaminase activity
GWK26_RS01300	COG1271	oxidase subunit
GWK26_RS01335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK26_RS01340	COG1120	ATPase activity
GWK26_RS01350	COG2271	Major facilitator Superfamily
GWK26_RS01360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK26_RS01365	COG3002	Belongs to the UPF0753 family
GWK26_RS01370	COG0473	3-isopropylmalate dehydrogenase activity
GWK26_RS01375	COG0066	3-isopropylmalate dehydratase activity
GWK26_RS01380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK26_RS01385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GWK26_RS01390	COG0440	acetolactate synthase activity
GWK26_RS01395	COG0028	Belongs to the TPP enzyme family
GWK26_RS01400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK26_RS01420	COG4106	trans-aconitate 2-methyltransferase activity
GWK26_RS01445	COG5001	Diguanylate cyclase
GWK26_RS01470	COG0277	FAD linked oxidase domain protein
GWK26_RS01470	COG0247	lactate metabolic process
GWK26_RS01480	COG1139	Iron-sulfur cluster binding protein
GWK26_RS01495	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK26_RS01500	COG1522	sequence-specific DNA binding
GWK26_RS01515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK26_RS01540	COG1988	membrane-bound metal-dependent
GWK26_RS01560	COG2264	protein methyltransferase activity
GWK26_RS01590	COG2135	peptidase activity
GWK26_RS01605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GWK26_RS01605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GWK26_RS01620	COG1169	isochorismate synthase
GWK26_RS01640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK26_RS01665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWK26_RS01670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GWK26_RS01680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GWK26_RS01685	COG1793	dna ligase
GWK26_RS01695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GWK26_RS01705	COG0517	IMP dehydrogenase activity
GWK26_RS01710	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GWK26_RS01740	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GWK26_RS01755	COG0107	imidazoleglycerol-phosphate synthase activity
GWK26_RS01790	COG0569	domain protein
GWK26_RS01795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK26_RS01800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK26_RS01805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK26_RS01810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK26_RS01825	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
GWK26_RS01830	COG0492	ferredoxin-NADP+ reductase activity
GWK26_RS01840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK26_RS01850	COG2212	antiporter activity
GWK26_RS01855	COG1320	monovalent cation:proton antiporter activity
GWK26_RS01870	COG1006	Multisubunit Na H antiporter MnhC subunit
GWK26_RS01875	COG0651	ATP synthesis coupled electron transport
GWK26_RS01880	COG0651	ATP synthesis coupled electron transport
GWK26_RS01900	COG1024	Enoyl-CoA hydratase
GWK26_RS01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GWK26_RS01925	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
GWK26_RS01965	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GWK26_RS01970	COG1830	Aldolase
GWK26_RS02005	COG1193	negative regulation of DNA recombination
GWK26_RS02035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK26_RS02060	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWK26_RS02065	COG1177	transmembrane transport
GWK26_RS02080	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS02085	COG1940	carbohydrate kinase activity
GWK26_RS02090	COG3842	ATPase activity
GWK26_RS02095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK26_RS02105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS02130	COG3842	ATPase activity
GWK26_RS02140	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWK26_RS02145	COG1177	transmembrane transport
GWK26_RS02150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK26_RS02160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK26_RS02160	COG0519	Catalyzes the synthesis of GMP from XMP
GWK26_RS02165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GWK26_RS02190	COG0006	proline dipeptidase activity
GWK26_RS02205	COG3842	ATPase activity
GWK26_RS02210	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWK26_RS02215	COG1177	transmembrane transport
GWK26_RS02220	COG1562	ergosterol biosynthetic process
GWK26_RS02240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK26_RS02245	COG0154	amidase activity
GWK26_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
GWK26_RS02325	COG1028	Short-chain dehydrogenase reductase Sdr
GWK26_RS02335	COG0538	isocitrate dehydrogenase activity
GWK26_RS02340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK26_RS02410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK26_RS02415	COG3402	PFAM membrane-flanked domain
GWK26_RS02430	COG1131	(ABC) transporter
GWK26_RS02435	COG0109	protoheme IX farnesyltransferase activity
GWK26_RS02440	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GWK26_RS02440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GWK26_RS02465	COG1902	pentaerythritol trinitrate reductase activity
GWK26_RS02495	COG1522	sequence-specific DNA binding
GWK26_RS02530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWK26_RS02545	COG1047	Peptidyl-prolyl cis-trans
GWK26_RS02565	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWK26_RS02570	COG0436	Aminotransferase
GWK26_RS02580	COG0295	cytidine deaminase activity
GWK26_RS02595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK26_RS02620	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GWK26_RS02635	COG0587	DNA-directed DNA polymerase activity
GWK26_RS02655	COG1473	amidohydrolase
GWK26_RS02660	COG2205	protein histidine kinase activity
GWK26_RS02675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK26_RS02680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK26_RS02685	COG1116	anion transmembrane transporter activity
GWK26_RS02705	COG0110	maltose O-acetyltransferase activity
GWK26_RS02710	COG0151	Belongs to the GarS family
GWK26_RS02715	COG1331	Highly conserved protein containing a thioredoxin domain
GWK26_RS02725	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GWK26_RS02730	COG0540	Belongs to the ATCase OTCase family
GWK26_RS02735	COG0633	Ferredoxin
GWK26_RS02795	COG1131	(ABC) transporter
GWK26_RS02890	COG1216	Glycosyl transferase, family 2
GWK26_RS02910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK26_RS02915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK26_RS02950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GWK26_RS02960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK26_RS02965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GWK26_RS03025	COG0626	cystathionine gamma-synthase activity
GWK26_RS03035	COG0798	PFAM Bile acid sodium symporter
GWK26_RS03045	COG0348	domain, Protein
GWK26_RS03095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK26_RS03125	COG1324	tolerance protein
GWK26_RS03135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GWK26_RS03160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GWK26_RS03165	COG0088	Forms part of the polypeptide exit tunnel
GWK26_RS03175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GWK26_RS03180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GWK26_RS03190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GWK26_RS03195	COG0255	Belongs to the universal ribosomal protein uL29 family
GWK26_RS03205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GWK26_RS03210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GWK26_RS03225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GWK26_RS03235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GWK26_RS03245	COG0322	excinuclease ABC activity
GWK26_RS03260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GWK26_RS03270	COG0200	Binds to the 23S rRNA
GWK26_RS03300	COG1078	dGTPase activity
GWK26_RS03315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK26_RS03315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK26_RS03330	COG1363	Peptidase, m42
GWK26_RS03335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GWK26_RS03365	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GWK26_RS03370	COG0151	Belongs to the GarS family
GWK26_RS03395	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GWK26_RS03415	COG0271	Belongs to the BolA IbaG family
GWK26_RS03420	COG0114	fumarate hydratase activity
GWK26_RS03425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK26_RS03440	COG1028	Short-chain dehydrogenase reductase Sdr
GWK26_RS03450	COG0644	oxidoreductase
GWK26_RS03465	COG0081	regulation of translation
GWK26_RS03475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GWK26_RS03490	COG0456	acetyltransferase
GWK26_RS03510	COG0667	Aldo Keto reductase
GWK26_RS03520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK26_RS03550	COG2855	membrane
GWK26_RS03555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GWK26_RS03560	COG0142	geranyltranstransferase activity
GWK26_RS03605	COG0431	NADPH-dependent FMN reductase
GWK26_RS03610	COG0589	response to stress
GWK26_RS03615	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GWK26_RS03615	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GWK26_RS03620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GWK26_RS03670	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWK26_RS03710	COG0489	protein tyrosine kinase activity
GWK26_RS03715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK26_RS03720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWK26_RS03725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GWK26_RS03730	COG0052	Belongs to the universal ribosomal protein uS2 family
GWK26_RS03735	COG0148	phosphopyruvate hydratase activity
GWK26_RS03750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWK26_RS03760	COG0200	Binds to the 23S rRNA
GWK26_RS03775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GWK26_RS03785	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GWK26_RS03795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK26_RS03805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GWK26_RS03810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK26_RS03820	COG2226	methyltransferase
GWK26_RS03880	COG0154	amidase activity
GWK26_RS03905	COG1966	Carbon starvation protein
GWK26_RS03920	COG1797	cobyrinic acid a,c-diamide synthase activity
GWK26_RS03945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK26_RS03970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK26_RS03975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK26_RS03990	COG0251	oxidation-reduction process
GWK26_RS04025	COG0431	NADPH-dependent FMN reductase
GWK26_RS04030	COG1546	Belongs to the CinA family
GWK26_RS04030	COG1058	Belongs to the CinA family
GWK26_RS04045	COG2154	pterin-4-alpha-carbinolamine dehydratase
GWK26_RS04050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK26_RS04055	COG2309	aminopeptidase activity
GWK26_RS04070	COG0174	glutamine synthetase
GWK26_RS04095	COG0189	ligase activity
GWK26_RS04105	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK26_RS04115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GWK26_RS04125	COG0439	Biotin carboxylase
GWK26_RS04135	COG0012	GTP binding
GWK26_RS04170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GWK26_RS04190	COG0415	Belongs to the DNA photolyase family
GWK26_RS04215	COG0589	response to stress
GWK26_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
GWK26_RS04225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GWK26_RS04260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK26_RS04270	COG3852	Histidine kinase
GWK26_RS04290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
GWK26_RS04305	COG0083	homoserine kinase activity
GWK26_RS04310	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GWK26_RS04315	COG0484	heat shock protein binding
GWK26_RS04320	COG0484	heat shock protein binding
GWK26_RS04325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWK26_RS04330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK26_RS04345	COG0528	UMP kinase activity
GWK26_RS04355	COG1216	Glycosyl transferase, family 2
GWK26_RS04365	COG0314	molybdopterin synthase activity
GWK26_RS04380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK26_RS04415	COG3842	ATPase activity
GWK26_RS04440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK26_RS04455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWK26_RS04470	COG0504	CTP synthase activity
GWK26_RS04475	COG0519	Catalyzes the synthesis of GMP from XMP
GWK26_RS04475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK26_RS04495	COG1185	polyribonucleotide nucleotidyltransferase activity
GWK26_RS04505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWK26_RS04525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GWK26_RS04535	COG1033	growth of symbiont in host cell
GWK26_RS04535	COG2409	Drug exporters of the RND superfamily
GWK26_RS04560	COG1136	(ABC) transporter
GWK26_RS04565	COG1136	(ABC) transporter
GWK26_RS04565	COG0577	efflux transmembrane transporter activity
GWK26_RS04580	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS04715	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GWK26_RS04735	COG0154	amidase activity
GWK26_RS04755	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS04810	COG1216	Glycosyl transferase, family 2
GWK26_RS04810	COG1442	glycosyl transferase family 8
GWK26_RS04905	COG1444	tRNA N-acetyltransferase activity
GWK26_RS04920	COG0277	FAD linked oxidase domain protein
GWK26_RS04920	COG0247	lactate metabolic process
GWK26_RS04935	COG1253	flavin adenine dinucleotide binding
GWK26_RS04950	COG0783	Belongs to the Dps family
GWK26_RS04960	COG1321	iron dependent repressor
GWK26_RS04970	COG1757	Na H antiporter
GWK26_RS04990	COG0531	amino acid
GWK26_RS05010	COG0535	radical SAM domain protein
GWK26_RS05020	COG0535	radical SAM domain protein
GWK26_RS05050	COG4251	negative regulation of phosphorylation
GWK26_RS05055	COG0784	Response regulator, receiver
GWK26_RS05060	COG0745	RESPONSE REGULATOR receiver
GWK26_RS05070	COG0450	alkyl hydroperoxide reductase
GWK26_RS05110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK26_RS05130	COG1116	anion transmembrane transporter activity
GWK26_RS05135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK26_RS05145	COG0633	Ferredoxin
GWK26_RS05145	COG3217	Mosc domain protein beta barrel domain protein
GWK26_RS05150	COG0436	Aminotransferase
GWK26_RS05180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK26_RS05315	COG2339	peptidase activity
GWK26_RS05330	COG0556	nucleotide-excision repair
GWK26_RS05360	COG2210	Belongs to the sulfur carrier protein TusA family
GWK26_RS05365	COG0425	Belongs to the sulfur carrier protein TusA family
GWK26_RS05405	COG0022	dehydrogenase e1 component
GWK26_RS05410	COG2610	gluconate transmembrane transporter activity
GWK26_RS05415	COG0277	FAD linked oxidase domain protein
GWK26_RS05425	COG2130	NADP-dependent
GWK26_RS05440	COG1132	(ABC) transporter
GWK26_RS05470	COG0210	DNA helicase
GWK26_RS05485	COG0704	Plays a role in the regulation of phosphate uptake
GWK26_RS05490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK26_RS05495	COG0581	inorganic phosphate transmembrane transporter activity
GWK26_RS05500	COG0573	inorganic phosphate transmembrane transporter activity
GWK26_RS05550	COG0688	phosphatidylethanolamine metabolic process
GWK26_RS05565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK26_RS05570	COG1234	tRNA 3'-trailer cleavage
GWK26_RS05585	COG1335	isochorismatase
GWK26_RS05590	COG3403	YqcI/YcgG family
GWK26_RS05595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK26_RS05620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWK26_RS05625	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GWK26_RS05630	COG2202	Pas domain
GWK26_RS05630	COG1366	Belongs to the anti-sigma-factor antagonist family
GWK26_RS05670	COG1741	Belongs to the pirin family
GWK26_RS05695	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS05700	COG2084	Dehydrogenase
GWK26_RS05725	COG0395	ABC-type sugar transport system, permease component
GWK26_RS05730	COG3842	ATPase activity
GWK26_RS05740	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS05745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GWK26_RS05760	COG3395	kinase activity
GWK26_RS05765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GWK26_RS05800	COG1733	regulation of RNA biosynthetic process
GWK26_RS05825	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK26_RS05830	COG2030	dehydratase
GWK26_RS05880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GWK26_RS05885	COG0085	RNA polymerase activity
GWK26_RS05890	COG0085	RNA polymerase activity
GWK26_RS05915	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK26_RS05935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWK26_RS05940	COG0402	S-adenosylhomocysteine deaminase activity
GWK26_RS05945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWK26_RS05950	COG1573	uracil-dna glycosylase
GWK26_RS05970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK26_RS05985	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWK26_RS05990	COG1177	transmembrane transport
GWK26_RS06000	COG3842	ATPase activity
GWK26_RS06005	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS06015	COG1605	Chorismate mutase
GWK26_RS06015	COG0077	Prephenate dehydratase
GWK26_RS06020	COG0495	leucyl-tRNA aminoacylation
GWK26_RS06035	COG1278	Cold shock
GWK26_RS06060	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS06080	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
GWK26_RS06090	COG0126	phosphoglycerate kinase activity
GWK26_RS06115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWK26_RS06120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWK26_RS06150	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWK26_RS06205	COG0805	protein transport
GWK26_RS06210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWK26_RS06225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK26_RS06245	COG1178	ABC-type Fe3 transport system permease component
GWK26_RS06250	COG3842	ATPase activity
GWK26_RS06255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWK26_RS06275	COG0459	protein refolding
GWK26_RS06280	COG1063	alcohol dehydrogenase
GWK26_RS06290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK26_RS06305	COG0730	response to heat
GWK26_RS06310	COG3118	belongs to the thioredoxin family
GWK26_RS06320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK26_RS06355	COG1073	alpha beta
GWK26_RS06355	COG2226	methyltransferase
GWK26_RS06360	COG0471	metal ion transport
GWK26_RS06360	COG3273	potassium ion transport
GWK26_RS06390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK26_RS06395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK26_RS06440	COG0322	excinuclease ABC activity
GWK26_RS06445	COG0527	aspartate kinase activity
GWK26_RS06460	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK26_RS06470	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK26_RS06480	COG2827	Endonuclease containing a URI domain
GWK26_RS06485	COG1691	(AIR) carboxylase
GWK26_RS06495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GWK26_RS06535	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK26_RS06595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK26_RS06605	COG0277	FAD linked oxidase domain protein
GWK26_RS06610	COG0372	Belongs to the citrate synthase family
GWK26_RS06630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS06635	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GWK26_RS06660	COG2894	cell division
GWK26_RS06670	COG1269	ATP hydrolysis coupled proton transport
GWK26_RS06695	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GWK26_RS06705	COG1394	ATPase activity, coupled to movement of substances
GWK26_RS06725	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GWK26_RS06735	COG3118	belongs to the thioredoxin family
GWK26_RS06745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK26_RS06750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GWK26_RS06770	COG0123	including yeast histone deacetylase and acetoin utilization protein
GWK26_RS06790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GWK26_RS06805	COG0432	Pfam Uncharacterised protein family UPF0047
GWK26_RS06855	COG2217	Heavy metal translocating P-type atpase
GWK26_RS06865	COG1607	acyl-coa hydrolase
GWK26_RS06875	COG0803	Belongs to the bacterial solute-binding protein 9 family
GWK26_RS06880	COG1121	(ABC) transporter
GWK26_RS06895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GWK26_RS06915	COG1216	Glycosyl transferase, family 2
GWK26_RS06925	COG2226	methyltransferase
GWK26_RS06950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK26_RS07000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK26_RS07015	COG1515	deoxyribonuclease V activity
GWK26_RS07020	COG0300	oxidoreductase activity
GWK26_RS07025	COG0003	Pfam Anion-transporting ATPase
GWK26_RS07070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK26_RS07095	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
GWK26_RS07100	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GWK26_RS07110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GWK26_RS07140	COG1253	flavin adenine dinucleotide binding
GWK26_RS07155	COG0435	Glutathione S-transferase
GWK26_RS07170	COG0134	indole-3-glycerol-phosphate synthase activity
GWK26_RS07175	COG0133	tryptophan synthase activity
GWK26_RS07180	COG0159	tryptophan synthase activity
GWK26_RS07185	COG1465	3-dehydroquinate synthase
GWK26_RS07195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS07200	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWK26_RS07245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GWK26_RS07270	COG2252	PERMEase
GWK26_RS07275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK26_RS07280	COG0142	geranyltranstransferase activity
GWK26_RS07290	COG0557	exoribonuclease II activity
GWK26_RS07295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK26_RS07305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK26_RS07335	COG0051	transcription antitermination factor activity, RNA binding
GWK26_RS07340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GWK26_RS07350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GWK26_RS07380	COG0037	tRNA processing
GWK26_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
GWK26_RS07390	COG1051	belongs to the nudix hydrolase family
GWK26_RS07390	COG1056	cytidyltransferase-related domain
GWK26_RS07395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GWK26_RS07410	COG0017	Asparaginyl-tRNA synthetase
GWK26_RS07430	COG1968	undecaprenyl-diphosphatase activity
GWK26_RS07435	COG1268	BioY protein
GWK26_RS07450	COG2181	nitrate reductase activity
GWK26_RS07450	COG0247	lactate metabolic process
GWK26_RS07485	COG0009	L-threonylcarbamoyladenylate synthase
GWK26_RS07520	COG0306	phosphate transporter
GWK26_RS07530	COG2514	catechol 2,3-dioxygenase activity
GWK26_RS07565	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GWK26_RS07570	COG3246	L-lysine catabolic process to acetate
GWK26_RS07575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWK26_RS07585	COG0596	Alpha beta hydrolase
GWK26_RS07590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK26_RS07590	COG0519	Catalyzes the synthesis of GMP from XMP
GWK26_RS07595	COG1960	acyl-CoA dehydrogenase activity
GWK26_RS07630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK26_RS07635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK26_RS07645	COG4974	Belongs to the 'phage' integrase family
GWK26_RS07655	COG0488	(ABC) transporter
GWK26_RS07685	COG0596	Alpha beta hydrolase
GWK26_RS07685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK26_RS07685	COG2226	methyltransferase
GWK26_RS07725	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
GWK26_RS07740	COG1606	tRNA processing
GWK26_RS07745	COG1193	negative regulation of DNA recombination
GWK26_RS07755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK26_RS07755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK26_RS07780	COG0330	HflC and HflK could
GWK26_RS07800	COG0463	Glycosyl transferase, family 2
GWK26_RS07810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GWK26_RS07825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK26_RS07925	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GWK26_RS07970	COG4536	flavin adenine dinucleotide binding
GWK26_RS07985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK26_RS08025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK26_RS08035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK26_RS08035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK26_RS08045	COG0596	Alpha beta hydrolase
GWK26_RS08055	COG0183	Belongs to the thiolase family
GWK26_RS08070	COG1185	polyribonucleotide nucleotidyltransferase activity
GWK26_RS08095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWK26_RS08145	COG1796	DNA polymerase
GWK26_RS08145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GWK26_RS08165	COG0494	nUDIX hydrolase
GWK26_RS08185	COG0616	signal peptide processing
GWK26_RS08195	COG0384	phenazine biosynthesis protein PhzF
GWK26_RS08205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK26_RS08220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWK26_RS08225	COG0419	ATPase involved in DNA repair
GWK26_RS08245	COG0396	ATPase activity
GWK26_RS08250	COG0719	Fe-S assembly protein
GWK26_RS08255	COG0719	Fe-S assembly protein
GWK26_RS08285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK26_RS08295	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GWK26_RS08295	COG0674	pyruvate-flavodoxin oxidoreductase activity
GWK26_RS08300	COG1013	pyruvate-flavodoxin oxidoreductase activity
GWK26_RS08310	COG0656	L-ascorbic acid biosynthetic process
GWK26_RS08335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK26_RS08340	COG0534	Mate efflux family protein
GWK26_RS08350	COG0436	Aminotransferase
GWK26_RS08360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GWK26_RS08365	COG2271	Major facilitator Superfamily
GWK26_RS08385	COG0717	Belongs to the dCTP deaminase family
GWK26_RS08400	COG0585	pseudouridine synthase activity
GWK26_RS08410	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GWK26_RS08430	COG1234	tRNA 3'-trailer cleavage
GWK26_RS08470	COG1492	cobalamin metabolic process
GWK26_RS08780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK26_RS08785	COG1280	lysine exporter protein (LysE YggA)
GWK26_RS08790	COG0371	Dehydrogenase
GWK26_RS08800	COG2030	dehydratase
GWK26_RS08825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GWK26_RS08855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK26_RS08895	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GWK26_RS08920	COG1196	nuclear chromosome segregation
GWK26_RS08930	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GWK26_RS08940	COG0067	glutamate synthase
GWK26_RS08940	COG0070	glutamate synthase
GWK26_RS08940	COG0069	glutamate synthase activity
GWK26_RS08945	COG0442	prolyl-tRNA aminoacylation
GWK26_RS08960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GWK26_RS08970	COG0438	transferase activity, transferring glycosyl groups
GWK26_RS08980	COG3119	arylsulfatase activity
GWK26_RS09005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK26_RS09025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK26_RS09085	COG2201	protein-glutamate methylesterase activity
GWK26_RS09110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK26_RS09115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GWK26_RS09135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GWK26_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK26_RS09170	COG1378	Sugar-specific transcriptional regulator TrmB
GWK26_RS09235	COG1132	(ABC) transporter
GWK26_RS09270	COG1083	cytidylyl-transferase
GWK26_RS09275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GWK26_RS09280	COG2089	acid synthase
GWK26_RS09310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GWK26_RS09345	COG0277	FAD linked oxidase domain protein
GWK26_RS09375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWK26_RS09380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWK26_RS09400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK26_RS09410	COG2171	N-acyltransferase activity
GWK26_RS09420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GWK26_RS09430	COG0010	Belongs to the arginase family
GWK26_RS09440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK26_RS09455	COG1122	ATPase activity
GWK26_RS09470	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWK26_RS09485	COG2875	Belongs to the precorrin methyltransferase family
GWK26_RS09520	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GWK26_RS09545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK26_RS09615	COG1045	serine acetyltransferase
GWK26_RS09620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK26_RS09625	COG0138	bifunctional purine biosynthesis protein purh
GWK26_RS09635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWK26_RS09640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GWK26_RS09645	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK26_RS09650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK26_RS09655	COG0649	NAD binding
GWK26_RS09670	COG0839	Belongs to the complex I subunit 6 family
GWK26_RS09680	COG0713	ATP synthesis coupled electron transport
GWK26_RS09690	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK26_RS09695	COG1007	ATP synthesis coupled electron transport
GWK26_RS09700	COG1227	inorganic diphosphatase activity
GWK26_RS09715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWK26_RS09735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GWK26_RS09740	COG3608	succinylglutamate desuccinylase aspartoacylase
GWK26_RS09750	COG0174	glutamine synthetase
GWK26_RS09760	COG4191	Histidine kinase
GWK26_RS09765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GWK26_RS09780	COG1051	belongs to the nudix hydrolase family
GWK26_RS09790	COG0443	Heat shock 70 kDa protein
GWK26_RS09795	COG0484	heat shock protein binding
GWK26_RS09805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK26_RS09815	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS09820	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWK26_RS09880	COG2814	Major facilitator Superfamily
GWK26_RS09895	COG0516	GMP reductase activity
GWK26_RS09900	COG0477	Major facilitator Superfamily
GWK26_RS09910	COG2264	protein methyltransferase activity
GWK26_RS09920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK26_RS09920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
GWK26_RS09935	COG1605	Chorismate mutase
GWK26_RS09935	COG0287	Prephenate dehydrogenase
GWK26_RS09960	COG1131	(ABC) transporter
GWK26_RS10020	COG0109	protoheme IX farnesyltransferase activity
GWK26_RS10035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK26_RS10055	COG0517	IMP dehydrogenase activity
GWK26_RS10080	COG4251	negative regulation of phosphorylation
GWK26_RS10095	COG0633	Ferredoxin
GWK26_RS10120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK26_RS10125	COG0509	glycine decarboxylation via glycine cleavage system
GWK26_RS10140	COG0864	Transcriptional regulator
GWK26_RS10150	COG1473	amidohydrolase
GWK26_RS10165	COG2860	membrane
GWK26_RS10175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK26_RS10180	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK26_RS10185	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GWK26_RS10190	COG0509	glycine decarboxylation via glycine cleavage system
GWK26_RS10200	COG1414	Transcriptional regulator
GWK26_RS10295	COG4347	Protein of unknown function (DUF1405)
GWK26_RS10330	COG1840	ABC-type Fe3 transport system, periplasmic component
GWK26_RS10355	COG0693	protein deglycase activity
GWK26_RS10360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK26_RS10365	COG0822	iron-sulfur transferase activity
GWK26_RS10375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK26_RS10385	COG1164	Oligoendopeptidase f
GWK26_RS10390	COG1247	-acetyltransferase
GWK26_RS10400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK26_RS10405	COG1836	PFAM Integral membrane protein DUF92
GWK26_RS10415	COG0358	DNA primase activity
GWK26_RS10440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GWK26_RS10445	COG1648	precorrin-2 dehydrogenase activity
GWK26_RS10445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK26_RS10475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GWK26_RS10480	COG0788	formyltetrahydrofolate deformylase activity
GWK26_RS10495	COG0166	Belongs to the GPI family
GWK26_RS10515	COG1278	Cold shock
GWK26_RS10525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GWK26_RS10535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GWK26_RS10555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GWK26_RS10565	COG1830	Aldolase
GWK26_RS10570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK26_RS10580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK26_RS10585	COG3938	Belongs to the proline racemase family
GWK26_RS10600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK26_RS10615	COG0309	Hydrogenase expression formation protein (HypE)
GWK26_RS10620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GWK26_RS10625	COG3360	Dodecin
GWK26_RS10665	COG0560	Phosphoserine phosphatase
GWK26_RS10675	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS10685	COG0704	Plays a role in the regulation of phosphate uptake
GWK26_RS10690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK26_RS10705	COG0024	Methionine aminopeptidase
GWK26_RS10715	COG0252	asparaginase activity
GWK26_RS10735	COG1414	Transcriptional regulator
GWK26_RS10740	COG0145	ligase activity
GWK26_RS10750	COG4647	ligase activity
GWK26_RS10755	COG0145	ligase activity
GWK26_RS10760	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
GWK26_RS10765	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GWK26_RS10770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GWK26_RS10775	COG0531	amino acid
GWK26_RS10790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GWK26_RS10795	COG1850	ribulose-bisphosphate carboxylase activity
GWK26_RS10800	COG0105	UTP biosynthetic process
GWK26_RS10830	COG0559	Belongs to the binding-protein-dependent transport system permease family
GWK26_RS10880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK26_RS10890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GWK26_RS10900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GWK26_RS10910	COG0517	IMP dehydrogenase activity
GWK26_RS10910	COG0516	GMP reductase activity
GWK26_RS10925	COG0464	growth
GWK26_RS10930	COG0183	Belongs to the thiolase family
GWK26_RS10975	COG0701	Predicted permease
GWK26_RS11005	COG3425	synthase
GWK26_RS11020	COG0733	neurotransmitter:sodium symporter activity
GWK26_RS11025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK26_RS11030	COG1233	COG1233 Phytoene dehydrogenase and related
GWK26_RS11065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK26_RS11065	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK26_RS11070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK26_RS11075	COG0135	phosphoribosylanthranilate isomerase activity
GWK26_RS11125	COG0517	IMP dehydrogenase activity
GWK26_RS11125	COG0516	GMP reductase activity
GWK26_RS11150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GWK26_RS11165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK26_RS11170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK26_RS11205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK26_RS11210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GWK26_RS11215	COG2086	electron transfer activity
GWK26_RS11230	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GWK26_RS11245	COG1510	regulation of RNA biosynthetic process
GWK26_RS11275	COG0251	oxidation-reduction process
GWK26_RS11280	COG5598	trimethylamine methyltransferase
GWK26_RS11295	COG0352	thiamine-phosphate diphosphorylase activity
GWK26_RS11310	COG1177	transmembrane transport
GWK26_RS11315	COG1176	ABC-type spermidine putrescine transport system, permease component I
GWK26_RS11320	COG3842	ATPase activity
GWK26_RS11335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS11340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK26_RS11360	COG2271	Major facilitator Superfamily
GWK26_RS11380	COG5002	protein histidine kinase activity
GWK26_RS11420	COG0710	3-dehydroquinate dehydratase activity
GWK26_RS11425	COG0460	homoserine dehydrogenase
GWK26_RS11440	COG2379	hydroxypyruvate reductase
GWK26_RS11445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GWK26_RS11460	COG1024	Enoyl-CoA hydratase
GWK26_RS11470	COG0579	oxidoreductase
GWK26_RS11480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GWK26_RS11495	COG0183	Belongs to the thiolase family
GWK26_RS11500	COG1960	acyl-CoA dehydrogenase activity
GWK26_RS11505	COG1024	Enoyl-CoA hydratase
GWK26_RS11555	COG1024	Enoyl-CoA hydratase
GWK26_RS11560	COG1024	Enoyl-CoA hydratase
GWK26_RS11565	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK26_RS11570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GWK26_RS11570	COG0301	tRNA thio-modification
GWK26_RS11585	COG0006	proline dipeptidase activity
GWK26_RS11625	COG0321	lipoyl(octanoyl) transferase activity
GWK26_RS11625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GWK26_RS11630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GWK26_RS11640	COG0668	transmembrane transport
GWK26_RS11660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK26_RS11675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GWK26_RS11690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK26_RS11695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK26_RS11740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK26_RS11760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GWK26_RS11765	COG0351	phosphomethylpyrimidine kinase
GWK26_RS11770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWK26_RS11805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK26_RS11970	COG3852	Histidine kinase
GWK26_RS11980	COG0129	dihydroxy-acid dehydratase activity
GWK26_RS11985	COG0047	phosphoribosylformylglycinamidine synthase activity
GWK26_RS12010	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWK26_RS12015	COG3852	Histidine kinase
GWK26_RS12050	COG1518	maintenance of DNA repeat elements
GWK26_RS12055	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GWK26_RS12080	COG0864	Transcriptional regulator
GWK26_RS12105	COG0589	response to stress
GWK26_RS12130	COG0668	transmembrane transport
GWK26_RS12135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
GWK26_RS12145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK26_RS12155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GWK26_RS12195	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GWK26_RS12240	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK26_RS12270	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
GWK26_RS12275	COG1295	ribonuclease BN
GWK26_RS12295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK26_RS12320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK26_RS12340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GWK26_RS12345	COG1522	sequence-specific DNA binding
GWK26_RS12355	COG1278	Cold shock
GWK26_RS12360	COG0483	inositol monophosphate 1-phosphatase activity
GWK26_RS12390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GWK26_RS12395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GWK26_RS12465	COG2873	o-acetylhomoserine
GWK26_RS12470	COG0039	L-malate dehydrogenase activity
GWK26_RS12480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GWK26_RS12485	COG4581	dead DEAH box helicase
GWK26_RS12520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GWK26_RS12525	COG0596	Alpha beta hydrolase
GWK26_RS12705	COG2226	methyltransferase
GWK26_RS12885	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
GWK26_RS12935	COG0563	adenylate kinase activity
GWK26_RS12960	COG0505	Belongs to the CarA family
GWK26_RS12970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GWK26_RS12975	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWK26_RS12995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GWK26_RS13005	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK26_RS13010	COG0018	arginyl-trna synthetase
GWK26_RS13040	COG1378	Sugar-specific transcriptional regulator TrmB
GWK26_RS13080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWK26_RS13095	COG0303	'Molybdopterin
GWK26_RS13100	COG0589	response to stress
GWK26_RS13115	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GWK26_RS13120	COG2116	formate transmembrane transporter activity
GWK26_RS13160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK26_RS13170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWK26_RS13175	COG0501	Belongs to the peptidase M48B family
GWK26_RS13190	COG1739	Uncharacterized protein family UPF0029
GWK26_RS13200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GWK26_RS13220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GWK26_RS13240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK26_RS13250	COG0750	zinc metalloprotease
GWK26_RS13265	COG0778	Nitroreductase
GWK26_RS13265	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
GWK26_RS13280	COG0667	Aldo Keto reductase
GWK26_RS13295	COG0101	tRNA pseudouridine synthase activity
GWK26_RS13345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWK26_RS13350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GWK26_RS13355	COG0459	protein refolding
GWK26_RS13370	COG2226	methyltransferase
GWK26_RS13375	COG1131	(ABC) transporter
GWK26_RS13380	COG0842	Transport permease protein
GWK26_RS13410	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
GWK26_RS13415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK26_RS13445	COG0281	malic enzyme
GWK26_RS13445	COG0280	phosphate acetyltransferase
GWK26_RS13450	COG0475	glutathione-regulated potassium exporter activity
GWK26_RS13455	COG0490	domain, Protein
GWK26_RS13475	COG0423	glycine-tRNA ligase activity
GWK26_RS13500	COG1902	pentaerythritol trinitrate reductase activity
GWK26_RS13510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK26_RS13515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK26_RS13520	COG0436	Aminotransferase
GWK26_RS13540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS13550	COG1414	Transcriptional regulator
GWK26_RS13595	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK26_RS13600	COG2005	Transcriptional regulator
GWK26_RS13600	COG3585	molybdate ion transport
GWK26_RS13625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK26_RS13630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK26_RS13650	COG0167	dihydroorotate dehydrogenase activity
GWK26_RS13660	COG0579	oxidoreductase
GWK26_RS13665	COG2814	Major facilitator Superfamily
GWK26_RS13685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GWK26_RS13695	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS13700	COG3842	ATPase activity
GWK26_RS13705	COG0395	ABC-type sugar transport system, permease component
GWK26_RS13715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK26_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS13735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK26_RS13740	COG4948	Mandelate Racemase Muconate Lactonizing
GWK26_RS13745	COG1312	Catalyzes the dehydration of D-mannonate
GWK26_RS13755	COG0028	Belongs to the TPP enzyme family
GWK26_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS13770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK26_RS13775	COG1414	Transcriptional regulator
GWK26_RS13795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GWK26_RS13800	COG0131	Imidazoleglycerol-phosphate dehydratase
GWK26_RS13830	COG0004	ammonium transporteR
GWK26_RS13840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GWK26_RS13845	COG0181	hydroxymethylbilane synthase activity
GWK26_RS13850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK26_RS13850	COG1648	precorrin-2 dehydrogenase activity
GWK26_RS13870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GWK26_RS13875	COG1131	(ABC) transporter
GWK26_RS13950	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GWK26_RS13955	COG0581	inorganic phosphate transmembrane transporter activity
GWK26_RS13960	COG0573	inorganic phosphate transmembrane transporter activity
GWK26_RS13965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWK26_RS13970	COG0124	histidyl-tRNA synthetase
GWK26_RS13985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK26_RS13990	COG2873	o-acetylhomoserine
GWK26_RS14060	COG1012	belongs to the aldehyde dehydrogenase family
GWK26_RS14065	COG1022	Amp-dependent synthetase and ligase
GWK26_RS14075	COG2226	methyltransferase
GWK26_RS14120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWK26_RS14170	COG0113	porphobilinogen synthase activity
GWK26_RS14180	COG0346	lactoylglutathione lyase activity
GWK26_RS14185	COG0284	orotidine-5'-phosphate decarboxylase activity
GWK26_RS14220	COG0702	epimerase
GWK26_RS14240	COG0137	argininosuccinate synthase activity
GWK26_RS14245	COG0165	Argininosuccinate lyase
GWK26_RS14255	COG0189	ligase activity
GWK26_RS14260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GWK26_RS14265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GWK26_RS14270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK26_RS14275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GWK26_RS14280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GWK26_RS14320	COG0346	lactoylglutathione lyase activity