locus-tag	class	description
HALAR_RS00020	COG0747	negative chemotaxis
HALAR_RS00025	COG0601	transmembrane transport
HALAR_RS00030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS00035	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS00045	COG0517	IMP dehydrogenase activity
HALAR_RS00045	COG0617	tRNA 3'-terminal CCA addition
HALAR_RS00045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HALAR_RS00070	COG3177	Filamentation induced by cAMP protein fic
HALAR_RS00085	COG0006	proline dipeptidase activity
HALAR_RS00105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HALAR_RS00110	COG1607	acyl-coa hydrolase
HALAR_RS00135	COG0110	maltose O-acetyltransferase activity
HALAR_RS00165	COG1830	Aldolase
HALAR_RS00175	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALAR_RS00180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HALAR_RS00200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HALAR_RS00205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HALAR_RS00210	COG0436	Aminotransferase
HALAR_RS00225	COG0667	Aldo Keto reductase
HALAR_RS00255	COG0215	cysteine-tRNA ligase activity
HALAR_RS00280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALAR_RS00330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALAR_RS00335	COG1058	Belongs to the CinA family
HALAR_RS00335	COG1546	Belongs to the CinA family
HALAR_RS00360	COG0175	sulfate reduction
HALAR_RS00380	COG3842	ATPase activity
HALAR_RS00385	COG1176	ABC-type spermidine putrescine transport system, permease component I
HALAR_RS00390	COG1177	transmembrane transport
HALAR_RS00400	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HALAR_RS00430	COG2226	methyltransferase
HALAR_RS00440	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HALAR_RS00445	COG0138	bifunctional purine biosynthesis protein purh
HALAR_RS00480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HALAR_RS00485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HALAR_RS00520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HALAR_RS00525	COG1120	ATPase activity
HALAR_RS00530	COG2264	protein methyltransferase activity
HALAR_RS00550	COG2339	peptidase activity
HALAR_RS00605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HALAR_RS00615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HALAR_RS00625	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALAR_RS00625	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALAR_RS00630	COG0783	Belongs to the Dps family
HALAR_RS00645	COG1363	Peptidase, m42
HALAR_RS00660	COG3794	PFAM blue (type 1) copper domain protein
HALAR_RS00670	COG0674	pyruvate-flavodoxin oxidoreductase activity
HALAR_RS00670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HALAR_RS00675	COG1013	pyruvate-flavodoxin oxidoreductase activity
HALAR_RS00680	COG0534	Mate efflux family protein
HALAR_RS00690	COG0656	L-ascorbic acid biosynthetic process
HALAR_RS00705	COG0616	signal peptide processing
HALAR_RS00750	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HALAR_RS00760	COG0442	prolyl-tRNA aminoacylation
HALAR_RS00780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HALAR_RS00785	COG0436	Aminotransferase
HALAR_RS00790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HALAR_RS00830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HALAR_RS00830	COG1796	DNA polymerase
HALAR_RS00840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HALAR_RS00855	COG2339	peptidase activity
HALAR_RS00875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HALAR_RS00910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HALAR_RS00920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALAR_RS00955	COG0557	exoribonuclease II activity
HALAR_RS00985	COG1468	defense response to virus
HALAR_RS00985	COG1518	maintenance of DNA repeat elements
HALAR_RS01025	COG0051	transcription antitermination factor activity, RNA binding
HALAR_RS01030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALAR_RS01035	COG0460	homoserine dehydrogenase
HALAR_RS01045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HALAR_RS01075	COG0049	tRNA binding
HALAR_RS01090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HALAR_RS01095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HALAR_RS01100	COG0085	RNA polymerase activity
HALAR_RS01105	COG0085	RNA polymerase activity
HALAR_RS01120	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HALAR_RS01145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HALAR_RS01155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HALAR_RS01175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HALAR_RS01180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HALAR_RS01185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HALAR_RS01200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALAR_RS01210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HALAR_RS01240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HALAR_RS01245	COG0822	iron-sulfur transferase activity
HALAR_RS01270	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HALAR_RS01280	COG0384	phenazine biosynthesis protein PhzF
HALAR_RS01295	COG1465	3-dehydroquinate synthase
HALAR_RS01325	COG0436	Aminotransferase
HALAR_RS01330	COG0435	Glutathione S-transferase
HALAR_RS01340	COG0717	Belongs to the dCTP deaminase family
HALAR_RS01410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALAR_RS01410	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HALAR_RS01420	COG0556	nucleotide-excision repair
HALAR_RS01455	COG4948	Mandelate Racemase Muconate Lactonizing
HALAR_RS01460	COG4948	Mandelate Racemase Muconate Lactonizing
HALAR_RS01485	COG0179	Fumarylacetoacetate (FAA) hydrolase
HALAR_RS01490	COG0501	Belongs to the peptidase M48B family
HALAR_RS01540	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HALAR_RS01550	COG1024	Enoyl-CoA hydratase
HALAR_RS01585	COG1012	belongs to the aldehyde dehydrogenase family
HALAR_RS01595	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HALAR_RS01595	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HALAR_RS01600	COG0315	cyclic pyranopterin monophosphate synthase activity
HALAR_RS01605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HALAR_RS01660	COG1012	belongs to the aldehyde dehydrogenase family
HALAR_RS01695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALAR_RS01705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALAR_RS01725	COG0351	phosphomethylpyrimidine kinase
HALAR_RS01730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HALAR_RS01740	COG1492	cobalamin metabolic process
HALAR_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
HALAR_RS01775	COG3842	ATPase activity
HALAR_RS01815	COG0179	Fumarylacetoacetate (FAA) hydrolase
HALAR_RS01895	COG1414	Transcriptional regulator
HALAR_RS01910	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HALAR_RS01970	COG0154	amidase activity
HALAR_RS01980	COG0823	Involved in the tonB-independent uptake of proteins
HALAR_RS01980	COG4946	Tricorn protease homolog
HALAR_RS01980	COG1506	peptidase
HALAR_RS01990	COG0601	transmembrane transport
HALAR_RS01995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS02030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HALAR_RS02040	COG0598	Magnesium transport protein CorA
HALAR_RS02050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALAR_RS02075	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS02080	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS02085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS02090	COG0601	transmembrane transport
HALAR_RS02095	COG4166	transmembrane transport
HALAR_RS02140	COG0484	heat shock protein binding
HALAR_RS02150	COG0783	Belongs to the Dps family
HALAR_RS02165	COG1902	pentaerythritol trinitrate reductase activity
HALAR_RS02170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALAR_RS02210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HALAR_RS02225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HALAR_RS02225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HALAR_RS02230	COG0109	protoheme IX farnesyltransferase activity
HALAR_RS02245	COG1733	regulation of RNA biosynthetic process
HALAR_RS02250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALAR_RS02275	COG3920	Histidine kinase
HALAR_RS02290	COG0560	Phosphoserine phosphatase
HALAR_RS02290	COG3830	Belongs to the UPF0237 family
HALAR_RS02295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HALAR_RS02345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HALAR_RS02350	COG0137	argininosuccinate synthase activity
HALAR_RS02355	COG0165	Argininosuccinate lyase
HALAR_RS02365	COG0189	ligase activity
HALAR_RS02370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HALAR_RS02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HALAR_RS02380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALAR_RS02385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALAR_RS02390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HALAR_RS02400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALAR_RS02405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HALAR_RS02415	COG0395	ABC-type sugar transport system, permease component
HALAR_RS02420	COG1175	transmembrane transport
HALAR_RS02445	COG2414	aldehyde ferredoxin oxidoreductase
HALAR_RS02450	COG0657	acetylesterase activity
HALAR_RS02455	COG1192	Involved in chromosome partitioning
HALAR_RS02465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALAR_RS02475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALAR_RS02485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HALAR_RS02490	COG0714	Associated with various cellular activities
HALAR_RS02550	COG0437	4 iron, 4 sulfur cluster binding
HALAR_RS02555	COG3383	formate dehydrogenase (NAD+) activity
HALAR_RS02590	COG2414	aldehyde ferredoxin oxidoreductase
HALAR_RS02600	COG2205	protein histidine kinase activity
HALAR_RS02605	COG0517	IMP dehydrogenase activity
HALAR_RS02605	COG1125	glycine betaine transport
HALAR_RS02630	COG1505	serine-type exopeptidase activity
HALAR_RS02635	COG2124	cytochrome p450
HALAR_RS02645	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HALAR_RS02655	COG0656	L-ascorbic acid biosynthetic process
HALAR_RS02660	COG0154	amidase activity
HALAR_RS02665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALAR_RS02675	COG1960	acyl-CoA dehydrogenase activity
HALAR_RS02700	COG0028	Belongs to the TPP enzyme family
HALAR_RS02705	COG0425	Belongs to the sulfur carrier protein TusA family
HALAR_RS02705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HALAR_RS02715	COG1404	Belongs to the peptidase S8 family
HALAR_RS02740	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS02745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS02750	COG0601	transmembrane transport
HALAR_RS02780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALAR_RS02805	COG0151	Belongs to the GarS family
HALAR_RS02830	COG1098	S1 RNA binding domain
HALAR_RS02845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALAR_RS02860	COG0419	ATPase involved in DNA repair
HALAR_RS02910	COG0512	Glutamine amidotransferase of anthranilate synthase
HALAR_RS02910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HALAR_RS02915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HALAR_RS02925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HALAR_RS02940	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALAR_RS02955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HALAR_RS02970	COG2239	Acts as a magnesium transporter
HALAR_RS03000	COG0442	prolyl-tRNA aminoacylation
HALAR_RS03010	COG1007	ATP synthesis coupled electron transport
HALAR_RS03015	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALAR_RS03050	COG0649	NAD binding
HALAR_RS03050	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALAR_RS03055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALAR_RS03060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HALAR_RS03075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HALAR_RS03080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HALAR_RS03105	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HALAR_RS03110	COG0540	Belongs to the ATCase OTCase family
HALAR_RS03115	COG1193	negative regulation of DNA recombination
HALAR_RS03130	COG2391	methyltransferase activity
HALAR_RS03145	COG1960	acyl-CoA dehydrogenase activity
HALAR_RS03150	COG0318	PFAM AMP-dependent synthetase and ligase
HALAR_RS03160	COG0346	lactoylglutathione lyase activity
HALAR_RS03165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALAR_RS03165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALAR_RS03205	COG1024	Enoyl-CoA hydratase
HALAR_RS03215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HALAR_RS03230	COG1253	flavin adenine dinucleotide binding
HALAR_RS03245	COG1546	Belongs to the CinA family
HALAR_RS03245	COG1058	Belongs to the CinA family
HALAR_RS03250	COG2226	methyltransferase
HALAR_RS03260	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HALAR_RS03285	COG0657	acetylesterase activity
HALAR_RS03345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HALAR_RS03360	COG0066	3-isopropylmalate dehydratase activity
HALAR_RS03365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HALAR_RS03375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HALAR_RS03385	COG0028	Belongs to the TPP enzyme family
HALAR_RS03390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HALAR_RS03395	COG0129	dihydroxy-acid dehydratase activity
HALAR_RS03410	COG0864	Transcriptional regulator
HALAR_RS03435	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS03440	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS03445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS03450	COG0601	transmembrane transport
HALAR_RS03465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HALAR_RS03500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HALAR_RS03505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HALAR_RS03515	COG0483	inositol monophosphate 1-phosphatase activity
HALAR_RS03550	COG0561	phosphatase activity
HALAR_RS03565	COG1960	acyl-CoA dehydrogenase activity
HALAR_RS03575	COG0668	transmembrane transport
HALAR_RS03590	COG0438	transferase activity, transferring glycosyl groups
HALAR_RS03615	COG1960	acyl-CoA dehydrogenase activity
HALAR_RS03645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALAR_RS03655	COG0745	RESPONSE REGULATOR receiver
HALAR_RS03660	COG0516	GMP reductase activity
HALAR_RS03660	COG0517	IMP dehydrogenase activity
HALAR_RS03675	COG2379	hydroxypyruvate reductase
HALAR_RS03690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HALAR_RS03700	COG0517	IMP dehydrogenase activity
HALAR_RS03730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HALAR_RS03755	COG0154	amidase activity
HALAR_RS03770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HALAR_RS03785	COG1575	Belongs to the MenA family. Type 1 subfamily
HALAR_RS03790	COG4948	Mandelate Racemase Muconate Lactonizing
HALAR_RS03795	COG1024	Enoyl-CoA hydratase
HALAR_RS03800	COG1757	Na H antiporter
HALAR_RS03805	COG2873	o-acetylhomoserine
HALAR_RS03810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HALAR_RS03820	COG0534	Mate efflux family protein
HALAR_RS03890	COG0535	radical SAM domain protein
HALAR_RS03900	COG4263	nitrous-oxide reductase activity
HALAR_RS03935	COG2205	protein histidine kinase activity
HALAR_RS03980	COG1435	thymidine kinase activity
HALAR_RS03990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HALAR_RS04000	COG0148	phosphopyruvate hydratase activity
HALAR_RS04015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HALAR_RS04040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HALAR_RS04045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HALAR_RS04050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HALAR_RS04060	COG3246	L-lysine catabolic process to acetate
HALAR_RS04075	COG0489	protein tyrosine kinase activity
HALAR_RS04110	COG0572	uridine kinase
HALAR_RS04130	COG0436	Aminotransferase
HALAR_RS04140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HALAR_RS04170	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HALAR_RS04170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HALAR_RS04225	COG0501	Belongs to the peptidase M48B family
HALAR_RS04230	COG1253	flavin adenine dinucleotide binding
HALAR_RS04250	COG1216	Glycosyl transferase, family 2
HALAR_RS04250	COG1442	glycosyl transferase family 8
HALAR_RS04285	COG3119	arylsulfatase activity
HALAR_RS04300	COG3119	arylsulfatase activity
HALAR_RS04310	COG0297	glycogen (starch) synthase activity
HALAR_RS04315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HALAR_RS04330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HALAR_RS04335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HALAR_RS04370	COG0247	lactate metabolic process
HALAR_RS04370	COG0277	FAD linked oxidase domain protein
HALAR_RS04375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HALAR_RS04390	COG0602	queuosine metabolic process
HALAR_RS04395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HALAR_RS04405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALAR_RS04415	COG0415	Belongs to the DNA photolyase family
HALAR_RS04430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HALAR_RS04440	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HALAR_RS04445	COG0346	lactoylglutathione lyase activity
HALAR_RS04460	COG3383	formate dehydrogenase (NAD+) activity
HALAR_RS04545	COG1845	cytochrome c oxidase, subunit III
HALAR_RS04545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HALAR_RS04565	COG0012	GTP binding
HALAR_RS04615	COG0154	amidase activity
HALAR_RS04625	COG4166	transmembrane transport
HALAR_RS04630	COG0601	transmembrane transport
HALAR_RS04635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS04640	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS04645	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS04705	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HALAR_RS04715	COG1793	dna ligase
HALAR_RS04720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HALAR_RS04730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALAR_RS04760	COG0012	GTP binding
HALAR_RS04775	COG0531	amino acid
HALAR_RS04795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HALAR_RS04800	COG1285	pathogenesis
HALAR_RS04825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HALAR_RS04830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HALAR_RS04850	COG0402	S-adenosylhomocysteine deaminase activity
HALAR_RS04855	COG0439	Biotin carboxylase
HALAR_RS04870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HALAR_RS04880	COG0006	proline dipeptidase activity
HALAR_RS04905	COG0010	Belongs to the arginase family
HALAR_RS04925	COG3842	ATPase activity
HALAR_RS04930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HALAR_RS04935	COG1177	transmembrane transport
HALAR_RS04945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALAR_RS04950	COG1402	creatininase
HALAR_RS04970	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALAR_RS04990	COG0559	Belongs to the binding-protein-dependent transport system permease family
HALAR_RS05010	COG0725	ABC transporter, periplasmic molybdate-binding protein
HALAR_RS05015	COG4208	sulfate ABC transporter
HALAR_RS05020	COG3842	ATPase activity
HALAR_RS05030	COG0644	oxidoreductase
HALAR_RS05060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HALAR_RS05065	COG1078	dGTPase activity
HALAR_RS05075	COG0778	Nitroreductase
HALAR_RS05075	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HALAR_RS05080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALAR_RS05125	COG1469	GTP cyclohydrolase I activity
HALAR_RS05130	COG1378	Sugar-specific transcriptional regulator TrmB
HALAR_RS05140	COG0316	Belongs to the HesB IscA family
HALAR_RS05150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HALAR_RS05155	COG1278	Cold shock
HALAR_RS05180	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HALAR_RS05185	COG3842	ATPase activity
HALAR_RS05190	COG0395	ABC-type sugar transport system, permease component
HALAR_RS05195	COG1175	transmembrane transport
HALAR_RS05205	COG1136	(ABC) transporter
HALAR_RS05210	COG0577	efflux transmembrane transporter activity
HALAR_RS05240	COG2226	methyltransferase
HALAR_RS05240	COG1073	alpha beta
HALAR_RS05260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HALAR_RS05280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HALAR_RS05315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HALAR_RS05325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HALAR_RS05335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HALAR_RS05340	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HALAR_RS05355	COG0626	cystathionine gamma-synthase activity
HALAR_RS05375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HALAR_RS05380	COG0668	transmembrane transport
HALAR_RS05410	COG3608	succinylglutamate desuccinylase aspartoacylase
HALAR_RS05425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HALAR_RS05450	COG0081	regulation of translation
HALAR_RS05475	COG0142	geranyltranstransferase activity
HALAR_RS05495	COG1522	sequence-specific DNA binding
HALAR_RS05500	COG0483	inositol monophosphate 1-phosphatase activity
HALAR_RS05510	COG4191	Histidine kinase
HALAR_RS05530	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HALAR_RS05535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALAR_RS05540	COG0667	Aldo Keto reductase
HALAR_RS05555	COG0704	Plays a role in the regulation of phosphate uptake
HALAR_RS05560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HALAR_RS05565	COG0573	inorganic phosphate transmembrane transporter activity
HALAR_RS05570	COG0573	inorganic phosphate transmembrane transporter activity
HALAR_RS05575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HALAR_RS05580	COG0704	Plays a role in the regulation of phosphate uptake
HALAR_RS05600	COG0668	transmembrane transport
HALAR_RS05605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HALAR_RS05615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HALAR_RS05620	COG0589	response to stress
HALAR_RS05630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HALAR_RS05665	COG1078	dGTPase activity
HALAR_RS05690	COG0714	Associated with various cellular activities
HALAR_RS05695	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HALAR_RS05700	COG1305	Transglutaminase-like
HALAR_RS05735	COG0456	acetyltransferase
HALAR_RS05740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HALAR_RS05775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALAR_RS05830	COG1335	isochorismatase
HALAR_RS05850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HALAR_RS05855	COG1053	succinate dehydrogenase
HALAR_RS05900	COG0569	domain protein
HALAR_RS05900	COG0189	ligase activity
HALAR_RS05910	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HALAR_RS05920	COG5002	protein histidine kinase activity
HALAR_RS05935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HALAR_RS05990	COG0667	Aldo Keto reductase
HALAR_RS06000	COG1473	amidohydrolase
HALAR_RS06020	COG0402	S-adenosylhomocysteine deaminase activity
HALAR_RS06055	COG4948	Mandelate Racemase Muconate Lactonizing
HALAR_RS06240	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS06245	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS06255	COG0601	transmembrane transport
HALAR_RS06265	COG0405	Gamma-glutamyltransferase
HALAR_RS06275	COG2267	carboxylic ester hydrolase activity
HALAR_RS06280	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS06285	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS06290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS06295	COG0601	transmembrane transport
HALAR_RS06305	COG0006	proline dipeptidase activity
HALAR_RS06315	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HALAR_RS06365	COG1228	amidohydrolase
HALAR_RS06380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HALAR_RS06390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HALAR_RS06405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HALAR_RS06425	COG0579	oxidoreductase
HALAR_RS06435	COG0306	phosphate transporter
HALAR_RS06525	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HALAR_RS06535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HALAR_RS06540	COG0010	Belongs to the arginase family
HALAR_RS06550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HALAR_RS06555	COG0509	glycine decarboxylation via glycine cleavage system
HALAR_RS06560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALAR_RS06565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HALAR_RS06575	COG2096	Adenosyltransferase
HALAR_RS06590	COG2205	protein histidine kinase activity
HALAR_RS06595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HALAR_RS06600	COG1960	acyl-CoA dehydrogenase activity
HALAR_RS06620	COG2267	carboxylic ester hydrolase activity
HALAR_RS06645	COG1131	(ABC) transporter
HALAR_RS06655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HALAR_RS06660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HALAR_RS06705	COG1233	COG1233 Phytoene dehydrogenase and related
HALAR_RS06740	COG0402	S-adenosylhomocysteine deaminase activity
HALAR_RS06770	COG0512	Glutamine amidotransferase of anthranilate synthase
HALAR_RS06770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HALAR_RS06780	COG0135	phosphoribosylanthranilate isomerase activity
HALAR_RS06850	COG0277	FAD linked oxidase domain protein
HALAR_RS06885	COG0656	L-ascorbic acid biosynthetic process
HALAR_RS06905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALAR_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
HALAR_RS06925	COG1012	belongs to the aldehyde dehydrogenase family
HALAR_RS06935	COG0601	transmembrane transport
HALAR_RS06940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS06945	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS06950	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS06955	COG0473	3-isopropylmalate dehydrogenase activity
HALAR_RS06965	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HALAR_RS06970	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HALAR_RS06985	COG0105	UTP biosynthetic process
HALAR_RS07005	COG1444	tRNA N-acetyltransferase activity
HALAR_RS07010	COG0348	domain, Protein
HALAR_RS07025	COG0154	amidase activity
HALAR_RS07050	COG0737	Belongs to the 5'-nucleotidase family
HALAR_RS07080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HALAR_RS07085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HALAR_RS07090	COG1363	Peptidase, m42
HALAR_RS07105	COG0446	pyridine nucleotide-disulphide oxidoreductase
HALAR_RS07125	COG2746	aminoglycoside 3-N-acetyltransferase activity
HALAR_RS07145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HALAR_RS07185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HALAR_RS07225	COG0154	amidase activity
HALAR_RS07245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HALAR_RS07255	COG0668	transmembrane transport
HALAR_RS07260	COG0436	Aminotransferase
HALAR_RS07270	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HALAR_RS07275	COG0277	FAD linked oxidase domain protein
HALAR_RS07280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HALAR_RS07290	COG0047	phosphoribosylformylglycinamidine synthase activity
HALAR_RS07325	COG0656	L-ascorbic acid biosynthetic process
HALAR_RS07350	COG0519	Catalyzes the synthesis of GMP from XMP
HALAR_RS07350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALAR_RS07355	COG0504	CTP synthase activity
HALAR_RS07370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HALAR_RS07385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HALAR_RS07410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HALAR_RS07480	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HALAR_RS07495	COG1131	(ABC) transporter
HALAR_RS07505	COG0322	excinuclease ABC activity
HALAR_RS07565	COG2135	peptidase activity
HALAR_RS07570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HALAR_RS07580	COG3852	Histidine kinase
HALAR_RS07600	COG1525	nuclease
HALAR_RS07615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS07620	COG0601	transmembrane transport
HALAR_RS07645	COG1832	CoA-binding protein
HALAR_RS07650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HALAR_RS07660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HALAR_RS07675	COG0179	Fumarylacetoacetate (FAA) hydrolase
HALAR_RS07680	COG0006	proline dipeptidase activity
HALAR_RS07690	COG0006	proline dipeptidase activity
HALAR_RS07700	COG3842	ATPase activity
HALAR_RS07710	COG1177	transmembrane transport
HALAR_RS07750	COG1254	Belongs to the acylphosphatase family
HALAR_RS07755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALAR_RS07765	COG3845	ABC transporter
HALAR_RS07770	COG4603	Belongs to the binding-protein-dependent transport system permease family
HALAR_RS07775	COG1079	Belongs to the binding-protein-dependent transport system permease family
HALAR_RS07785	COG1473	amidohydrolase
HALAR_RS07795	COG0494	nUDIX hydrolase
HALAR_RS07815	COG0492	ferredoxin-NADP+ reductase activity
HALAR_RS07825	COG0484	heat shock protein binding
HALAR_RS07855	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HALAR_RS07865	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HALAR_RS07900	COG0154	amidase activity
HALAR_RS07905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HALAR_RS07915	COG2133	pyrroloquinoline quinone binding
HALAR_RS07960	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HALAR_RS07970	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HALAR_RS07990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HALAR_RS08000	COG5000	phosphorelay sensor kinase activity
HALAR_RS08005	COG1132	(ABC) transporter
HALAR_RS08035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HALAR_RS08040	COG1320	monovalent cation:proton antiporter activity
HALAR_RS08045	COG2212	antiporter activity
HALAR_RS08050	COG1863	multisubunit Na H antiporter MnhE subunit
HALAR_RS08055	COG0651	ATP synthesis coupled electron transport
HALAR_RS08065	COG2111	Na H antiporter
HALAR_RS08070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HALAR_RS08070	COG2111	Na H antiporter
HALAR_RS08075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HALAR_RS08125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HALAR_RS08205	COG0531	amino acid
HALAR_RS08230	COG1074	ATP-dependent DNA helicase activity
HALAR_RS08310	COG2132	Multicopper oxidase
HALAR_RS08320	COG2076	Multidrug Resistance protein
HALAR_RS08325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HALAR_RS08335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALAR_RS08335	COG0519	Catalyzes the synthesis of GMP from XMP
HALAR_RS08360	COG0200	Binds to the 23S rRNA
HALAR_RS08385	COG0322	excinuclease ABC activity
HALAR_RS08390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HALAR_RS08395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HALAR_RS08405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HALAR_RS08420	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HALAR_RS08435	COG0255	Belongs to the universal ribosomal protein uL29 family
HALAR_RS08440	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HALAR_RS08450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HALAR_RS08455	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HALAR_RS08470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HALAR_RS08510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HALAR_RS08545	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HALAR_RS08590	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HALAR_RS08600	COG0668	transmembrane transport
HALAR_RS08610	COG1988	membrane-bound metal-dependent
HALAR_RS08645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HALAR_RS08695	COG0107	imidazoleglycerol-phosphate synthase activity
HALAR_RS08770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HALAR_RS08780	COG2089	acid synthase
HALAR_RS08810	COG1083	cytidylyl-transferase
HALAR_RS08820	COG0438	transferase activity, transferring glycosyl groups
HALAR_RS08830	COG1132	(ABC) transporter
HALAR_RS08855	COG0318	PFAM AMP-dependent synthetase and ligase
HALAR_RS08870	COG2264	protein methyltransferase activity
HALAR_RS08895	COG0589	response to stress
HALAR_RS08905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALAR_RS08905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HALAR_RS08935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HALAR_RS08940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HALAR_RS08955	COG0358	DNA primase activity
HALAR_RS09005	COG0709	Synthesizes selenophosphate from selenide and ATP
HALAR_RS09010	COG3844	kynureninase activity
HALAR_RS09020	COG1252	NADH dehydrogenase
HALAR_RS09090	COG0114	fumarate hydratase activity
HALAR_RS09095	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALAR_RS09105	COG0577	efflux transmembrane transporter activity
HALAR_RS09105	COG1136	(ABC) transporter
HALAR_RS09110	COG0577	efflux transmembrane transporter activity
HALAR_RS09110	COG1136	(ABC) transporter
HALAR_RS09175	COG0277	FAD linked oxidase domain protein
HALAR_RS09175	COG0247	lactate metabolic process
HALAR_RS09180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALAR_RS09185	COG1205	dead DEAH box helicase
HALAR_RS09185	COG1111	helicase
HALAR_RS09190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HALAR_RS09195	COG0443	Heat shock 70 kDa protein
HALAR_RS09200	COG0484	heat shock protein binding
HALAR_RS09210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HALAR_RS09225	COG0187	DNA topoisomerase II activity
HALAR_RS09225	COG1372	Participates in initiation and elongation during chromosome replication
HALAR_RS09265	COG1473	amidohydrolase
HALAR_RS09280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HALAR_RS09285	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS09295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS09300	COG0601	transmembrane transport
HALAR_RS09305	COG4166	transmembrane transport
HALAR_RS09325	COG0434	BtpA family
HALAR_RS09440	COG2205	protein histidine kinase activity
HALAR_RS09455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALAR_RS09460	COG1164	Oligoendopeptidase f
HALAR_RS09470	COG0101	tRNA pseudouridine synthase activity
HALAR_RS09475	COG0124	histidyl-tRNA synthetase
HALAR_RS09495	COG0392	lysyltransferase activity
HALAR_RS09495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HALAR_RS09500	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HALAR_RS09515	COG0314	molybdopterin synthase activity
HALAR_RS09520	COG0528	UMP kinase activity
HALAR_RS09525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HALAR_RS09535	COG1695	Transcriptional regulator
HALAR_RS09540	COG3253	May function as heme-dependent peroxidase
HALAR_RS09605	COG0662	Cupin 2, conserved barrel domain protein
HALAR_RS09630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HALAR_RS09640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HALAR_RS09665	COG1185	polyribonucleotide nucleotidyltransferase activity
HALAR_RS09675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HALAR_RS09690	COG0321	lipoyl(octanoyl) transferase activity
HALAR_RS09690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HALAR_RS09695	COG0464	growth
HALAR_RS09715	COG0183	Belongs to the thiolase family
HALAR_RS09720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALAR_RS09730	COG1022	Amp-dependent synthetase and ligase
HALAR_RS09745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HALAR_RS09760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HALAR_RS09775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HALAR_RS09780	COG2968	Membrane
HALAR_RS09790	COG0490	domain, Protein
HALAR_RS09795	COG0475	glutathione-regulated potassium exporter activity
HALAR_RS09820	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HALAR_RS09825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALAR_RS09845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HALAR_RS09855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HALAR_RS09885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HALAR_RS09905	COG0166	Belongs to the GPI family
HALAR_RS09945	COG0431	NADPH-dependent FMN reductase
HALAR_RS09980	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HALAR_RS09995	COG0505	Belongs to the CarA family
HALAR_RS10005	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HALAR_RS10010	COG2205	protein histidine kinase activity
HALAR_RS10020	COG1063	alcohol dehydrogenase
HALAR_RS10025	COG0521	Mo-molybdopterin cofactor biosynthetic process
HALAR_RS10075	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HALAR_RS10080	COG1102	Psort location Cytoplasmic, score
HALAR_RS10090	COG0303	'Molybdopterin
HALAR_RS10095	COG0303	'Molybdopterin
HALAR_RS10115	COG2154	pterin-4-alpha-carbinolamine dehydratase
HALAR_RS10120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HALAR_RS10145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HALAR_RS10160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HALAR_RS10170	COG0083	homoserine kinase activity
HALAR_RS10180	COG0284	orotidine-5'-phosphate decarboxylase activity
HALAR_RS10210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALAR_RS10245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HALAR_RS10255	COG0534	Mate efflux family protein
HALAR_RS10260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HALAR_RS10270	COG0022	dehydrogenase e1 component
HALAR_RS10290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALAR_RS10300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HALAR_RS10310	COG1012	belongs to the aldehyde dehydrogenase family
HALAR_RS10315	COG0028	Belongs to the TPP enzyme family
HALAR_RS10325	COG2217	Heavy metal translocating P-type atpase
HALAR_RS10340	COG0633	Ferredoxin
HALAR_RS10345	COG1739	Uncharacterized protein family UPF0029
HALAR_RS10360	COG0131	Imidazoleglycerol-phosphate dehydratase
HALAR_RS10380	COG0538	isocitrate dehydrogenase activity
HALAR_RS10385	COG1446	asparaginase
HALAR_RS10430	COG1185	polyribonucleotide nucleotidyltransferase activity
HALAR_RS10450	COG0018	arginyl-trna synthetase
HALAR_RS10460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HALAR_RS10460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HALAR_RS10500	COG2130	NADP-dependent
HALAR_RS10505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HALAR_RS10515	COG0590	tRNA wobble adenosine to inosine editing
HALAR_RS10515	COG0037	tRNA processing
HALAR_RS10520	COG2226	methyltransferase
HALAR_RS10530	COG2226	methyltransferase
HALAR_RS10540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HALAR_RS10600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HALAR_RS10605	COG0633	Ferredoxin
HALAR_RS10610	COG0534	Mate efflux family protein
HALAR_RS10665	COG0167	dihydroorotate dehydrogenase activity
HALAR_RS10705	COG0556	nucleotide-excision repair
HALAR_RS10720	COG2897	thiosulfate sulfurtransferase activity
HALAR_RS10765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HALAR_RS10785	COG0823	Involved in the tonB-independent uptake of proteins
HALAR_RS10785	COG1506	peptidase
HALAR_RS10785	COG4946	Tricorn protease homolog
HALAR_RS10825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HALAR_RS10830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HALAR_RS10835	COG0525	valine-tRNA ligase activity
HALAR_RS10850	COG0402	S-adenosylhomocysteine deaminase activity
HALAR_RS10875	COG3422	double-strand break repair
HALAR_RS10880	COG0688	phosphatidylethanolamine metabolic process
HALAR_RS10885	COG0470	DNA polymerase III
HALAR_RS10895	COG1234	tRNA 3'-trailer cleavage
HALAR_RS10975	COG0024	Methionine aminopeptidase
HALAR_RS10990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HALAR_RS11015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HALAR_RS11035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HALAR_RS11040	COG0431	NADPH-dependent FMN reductase
HALAR_RS11045	COG2827	Endonuclease containing a URI domain
HALAR_RS11060	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HALAR_RS11065	COG1280	lysine exporter protein (LysE YggA)
HALAR_RS11110	COG0142	geranyltranstransferase activity
HALAR_RS11115	COG2226	methyltransferase
HALAR_RS11115	COG0596	Alpha beta hydrolase
HALAR_RS11115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HALAR_RS11155	COG1269	ATP hydrolysis coupled proton transport
HALAR_RS11180	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HALAR_RS11185	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HALAR_RS11190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HALAR_RS11195	COG0459	protein refolding
HALAR_RS11200	COG1402	creatininase
HALAR_RS11215	COG0237	dephospho-CoA kinase activity
HALAR_RS11265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HALAR_RS11310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALAR_RS11320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALAR_RS11325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HALAR_RS11355	COG3608	succinylglutamate desuccinylase aspartoacylase
HALAR_RS11375	COG2999	glutathione oxidoreductase activity
HALAR_RS11385	COG2252	PERMEase
HALAR_RS11390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HALAR_RS11395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HALAR_RS11420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALAR_RS11420	COG0519	Catalyzes the synthesis of GMP from XMP
HALAR_RS11460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HALAR_RS11460	COG0475	glutathione-regulated potassium exporter activity
HALAR_RS11465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALAR_RS11480	COG0076	glutamate decarboxylase activity
HALAR_RS11500	COG0517	IMP dehydrogenase activity
HALAR_RS11500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HALAR_RS11500	COG0617	tRNA 3'-terminal CCA addition
HALAR_RS11505	COG0024	Methionine aminopeptidase
HALAR_RS11525	COG0531	amino acid
HALAR_RS11570	COG0798	PFAM Bile acid sodium symporter
HALAR_RS11580	COG0469	pyruvate kinase activity
HALAR_RS11585	COG1940	carbohydrate kinase activity
HALAR_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
HALAR_RS11605	COG2414	aldehyde ferredoxin oxidoreductase
HALAR_RS11610	COG3842	ATPase activity
HALAR_RS11620	COG1177	transmembrane transport
HALAR_RS11630	COG1522	sequence-specific DNA binding
HALAR_RS11645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HALAR_RS11650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALAR_RS11690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HALAR_RS11750	COG2894	cell division
HALAR_RS11755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALAR_RS11775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HALAR_RS11810	COG0077	Prephenate dehydratase
HALAR_RS11810	COG1605	Chorismate mutase
HALAR_RS11815	COG2205	protein histidine kinase activity
HALAR_RS11845	COG3273	potassium ion transport
HALAR_RS11845	COG0471	metal ion transport
HALAR_RS11855	COG1830	Aldolase
HALAR_RS11860	COG0159	tryptophan synthase activity
HALAR_RS11865	COG0133	tryptophan synthase activity
HALAR_RS11870	COG0134	indole-3-glycerol-phosphate synthase activity
HALAR_RS11885	COG1606	tRNA processing
HALAR_RS11890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HALAR_RS11960	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HALAR_RS11970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HALAR_RS11975	COG0251	oxidation-reduction process
HALAR_RS12025	COG0534	Mate efflux family protein
HALAR_RS12030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HALAR_RS12040	COG1196	nuclear chromosome segregation
HALAR_RS12065	COG3842	ATPase activity
HALAR_RS12085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HALAR_RS12095	COG0626	cystathionine gamma-synthase activity
HALAR_RS12150	COG0017	Asparaginyl-tRNA synthetase
HALAR_RS12155	COG1253	flavin adenine dinucleotide binding
HALAR_RS12165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HALAR_RS12170	COG0009	L-threonylcarbamoyladenylate synthase
HALAR_RS12185	COG1268	BioY protein
HALAR_RS12190	COG1122	ATPase activity
HALAR_RS12195	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HALAR_RS12205	COG0247	lactate metabolic process
HALAR_RS12205	COG2181	nitrate reductase activity
HALAR_RS12240	COG2226	methyltransferase
HALAR_RS12255	COG1216	Glycosyl transferase, family 2
HALAR_RS12275	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HALAR_RS12280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HALAR_RS12280	COG0519	Catalyzes the synthesis of GMP from XMP
HALAR_RS12285	COG1960	acyl-CoA dehydrogenase activity
HALAR_RS12325	COG0459	protein refolding
HALAR_RS12335	COG0710	3-dehydroquinate dehydratase activity
HALAR_RS12380	COG0330	HflC and HflK could
HALAR_RS12395	COG3842	ATPase activity
HALAR_RS12410	COG1473	amidohydrolase
HALAR_RS12420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HALAR_RS12450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HALAR_RS12450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HALAR_RS12465	COG0527	aspartate kinase activity
HALAR_RS12480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HALAR_RS12485	COG0372	Belongs to the citrate synthase family
HALAR_RS12515	COG1139	Iron-sulfur cluster binding protein
HALAR_RS12520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALAR_RS12540	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HALAR_RS12545	COG0140	phosphoribosyl-ATP diphosphatase activity
HALAR_RS12545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HALAR_RS12580	COG3616	Alanine racemase, N-terminal domain
HALAR_RS12605	COG0010	Belongs to the arginase family
HALAR_RS12610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HALAR_RS12635	COG1902	pentaerythritol trinitrate reductase activity
HALAR_RS12645	COG0501	Belongs to the peptidase M48B family
HALAR_RS12650	COG4948	Mandelate Racemase Muconate Lactonizing
HALAR_RS12660	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HALAR_RS12690	COG0601	transmembrane transport
HALAR_RS12695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS12705	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS12725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HALAR_RS12730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HALAR_RS12735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HALAR_RS12750	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALAR_RS12795	COG0123	including yeast histone deacetylase and acetoin utilization protein
HALAR_RS12850	COG0113	porphobilinogen synthase activity
HALAR_RS12855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HALAR_RS12860	COG0181	hydroxymethylbilane synthase activity
HALAR_RS12885	COG1067	ATP-dependent peptidase activity
HALAR_RS12885	COG0470	DNA polymerase III
HALAR_RS12895	COG0805	protein transport
HALAR_RS12900	COG0805	protein transport
HALAR_RS12915	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HALAR_RS12935	COG0589	response to stress
HALAR_RS12960	COG0667	Aldo Keto reductase
HALAR_RS12970	COG4251	negative regulation of phosphorylation
HALAR_RS12975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HALAR_RS13010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HALAR_RS13020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALAR_RS13030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HALAR_RS13035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HALAR_RS13040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HALAR_RS13060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HALAR_RS13065	COG1177	transmembrane transport
HALAR_RS13070	COG1176	ABC-type spermidine putrescine transport system, permease component I
HALAR_RS13075	COG3842	ATPase activity
HALAR_RS13085	COG0538	isocitrate dehydrogenase activity
HALAR_RS13110	COG0633	Ferredoxin
HALAR_RS13110	COG0543	2 iron, 2 sulfur cluster binding
HALAR_RS13135	COG0559	Belongs to the binding-protein-dependent transport system permease family
HALAR_RS13170	COG0747	negative chemotaxis
HALAR_RS13175	COG0601	transmembrane transport
HALAR_RS13180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS13190	COG2301	Belongs to the HpcH HpaI aldolase family
HALAR_RS13220	COG0489	protein tyrosine kinase activity
HALAR_RS13300	COG1278	Cold shock
HALAR_RS13340	COG3273	potassium ion transport
HALAR_RS13340	COG0471	metal ion transport
HALAR_RS13395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HALAR_RS13415	COG1132	(ABC) transporter
HALAR_RS13450	COG2210	Belongs to the sulfur carrier protein TusA family
HALAR_RS13455	COG0425	Belongs to the sulfur carrier protein TusA family
HALAR_RS13460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HALAR_RS13460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALAR_RS13470	COG2391	methyltransferase activity
HALAR_RS13530	COG0673	inositol 2-dehydrogenase activity
HALAR_RS13565	COG0587	DNA-directed DNA polymerase activity
HALAR_RS13570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HALAR_RS13575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALAR_RS13580	COG1201	RNA secondary structure unwinding
HALAR_RS13600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HALAR_RS13610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HALAR_RS13625	COG0674	pyruvate-flavodoxin oxidoreductase activity
HALAR_RS13625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HALAR_RS13630	COG1013	pyruvate-flavodoxin oxidoreductase activity
HALAR_RS13635	COG1522	sequence-specific DNA binding
HALAR_RS13640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HALAR_RS13665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HALAR_RS13665	COG1213	nucleotidyl transferase
HALAR_RS13675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HALAR_RS13685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HALAR_RS13705	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HALAR_RS13710	COG1253	flavin adenine dinucleotide binding
HALAR_RS13715	COG0301	tRNA thio-modification
HALAR_RS13725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HALAR_RS13735	COG1331	Highly conserved protein containing a thioredoxin domain
HALAR_RS13745	COG0151	Belongs to the GarS family
HALAR_RS13760	COG1024	Enoyl-CoA hydratase
HALAR_RS13765	COG1250	3-hydroxyacyl-CoA dehydrogenase
HALAR_RS13770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HALAR_RS13775	COG0183	Belongs to the thiolase family
HALAR_RS13780	COG1278	Cold shock
HALAR_RS13835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HALAR_RS13835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HALAR_RS13865	COG3396	Phenylacetate-CoA oxygenase
HALAR_RS13880	COG2151	metal-sulfur cluster biosynthetic enzyme
HALAR_RS13900	COG0396	ATPase activity
HALAR_RS13905	COG0719	Fe-S assembly protein
HALAR_RS13910	COG0719	Fe-S assembly protein
HALAR_RS13985	COG1278	Cold shock
HALAR_RS14000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HALAR_RS14015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HALAR_RS14020	COG0183	Belongs to the thiolase family
HALAR_RS14030	COG0596	Alpha beta hydrolase
HALAR_RS14060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HALAR_RS14085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HALAR_RS14090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HALAR_RS14135	COG1233	COG1233 Phytoene dehydrogenase and related
HALAR_RS14150	COG0484	heat shock protein binding
HALAR_RS14155	COG1506	peptidase
HALAR_RS14190	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALAR_RS14190	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HALAR_RS14195	COG1703	isobutyryl-CoA mutase activity
HALAR_RS14205	COG1546	Belongs to the CinA family
HALAR_RS14205	COG1058	Belongs to the CinA family
HALAR_RS14210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HALAR_RS14230	COG0563	adenylate kinase activity
HALAR_RS14245	COG0252	asparaginase activity
HALAR_RS14275	COG1231	oxidoreductase activity
HALAR_RS14290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HALAR_RS14310	COG0003	Pfam Anion-transporting ATPase
HALAR_RS14320	COG0300	oxidoreductase activity
HALAR_RS14325	COG1515	deoxyribonuclease V activity
HALAR_RS14380	COG0436	Aminotransferase
HALAR_RS14390	COG0210	DNA helicase
HALAR_RS14395	COG0006	proline dipeptidase activity
HALAR_RS14420	COG3842	ATPase activity
HALAR_RS14425	COG0189	ligase activity
HALAR_RS14435	COG0126	phosphoglycerate kinase activity
HALAR_RS14470	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HALAR_RS14545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HALAR_RS14550	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS14555	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS14560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS14565	COG0601	transmembrane transport
HALAR_RS14570	COG0747	negative chemotaxis
HALAR_RS14595	COG4948	Mandelate Racemase Muconate Lactonizing
HALAR_RS14600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HALAR_RS14605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALAR_RS14695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS14740	COG1570	exodeoxyribonuclease VII activity
HALAR_RS14920	COG3408	Glycogen debranching enzyme
HALAR_RS14920	COG3119	arylsulfatase activity
HALAR_RS14945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS15020	COG1397	ADP-ribosylglycohydrolase
HALAR_RS15035	COG0589	response to stress
HALAR_RS15075	COG1401	restriction endodeoxyribonuclease activity
HALAR_RS15135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS15215	COG1073	alpha beta
HALAR_RS15240	COG1476	TRANSCRIPTIONal
HALAR_RS15300	COG1196	nuclear chromosome segregation
HALAR_RS15525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS15615	COG1074	ATP-dependent DNA helicase activity
HALAR_RS15665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS15675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HALAR_RS15820	COG2205	protein histidine kinase activity
HALAR_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
HALAR_RS15845	COG0318	PFAM AMP-dependent synthetase and ligase
HALAR_RS15860	COG0179	Fumarylacetoacetate (FAA) hydrolase
HALAR_RS15865	COG0346	lactoylglutathione lyase activity
HALAR_RS15875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HALAR_RS15880	COG0601	transmembrane transport
HALAR_RS15890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HALAR_RS15890	COG3321	synthase
HALAR_RS15890	COG4221	oxidoreductase activity
HALAR_RS15890	COG0604	alcohol dehydrogenase
HALAR_RS15915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HALAR_RS15925	COG4608	Belongs to the ABC transporter superfamily
HALAR_RS15930	COG0444	Belongs to the ABC transporter superfamily
HALAR_RS15940	COG0427	acetyl-CoA hydrolase
HALAR_RS15955	COG1414	Transcriptional regulator
HALAR_RS16190	COG3385	transposase activity
HALAR_RS16215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS16215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS16275	COG2135	peptidase activity
HALAR_RS16285	COG0701	Predicted permease
HALAR_RS16465	COG0438	transferase activity, transferring glycosyl groups
HALAR_RS16515	COG2217	Heavy metal translocating P-type atpase
HALAR_RS16520	COG2217	Heavy metal translocating P-type atpase
HALAR_RS16530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HALAR_RS16555	COG0109	protoheme IX farnesyltransferase activity
HALAR_RS16580	COG3385	transposase activity
HALAR_RS16670	COG3385	transposase activity
HALAR_RS16695	COG0864	Transcriptional regulator
HALAR_RS16715	COG1192	Involved in chromosome partitioning
HALAR_RS16730	COG0270	DNA (cytosine-5-)-methyltransferase activity
HALAR_RS16790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HALAR_RS16870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HALAR_RS16895	COG5002	protein histidine kinase activity
HALAR_RS17060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HALAR_RS17125	COG2217	Heavy metal translocating P-type atpase
HALAR_RS17185	COG0297	glycogen (starch) synthase activity
HALAR_RS17210	COG1091	dTDP-4-dehydrorhamnose reductase activity
HALAR_RS17400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HALAR_RS17415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HALAR_RS17440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HALAR_RS17465	COG1192	Involved in chromosome partitioning
HALAR_RS17515	COG3385	transposase activity
HALAR_RS17540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HALAR_RS17575	COG3385	transposase activity
HALAR_RS17635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HALAR_RS17945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HALAR_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
HALAR_RS18670	COG0438	transferase activity, transferring glycosyl groups
HALAR_RS18830	COG0070	glutamate synthase
HALAR_RS18830	COG0069	glutamate synthase activity
HALAR_RS18830	COG0067	glutamate synthase