locus-tag	class	description
A359_RS00010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
A359_RS00015	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
A359_RS00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A359_RS00025	ENOG4105DSJ	YicC domain protein
A359_RS00030	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
A359_RS00035	ENOG4105MH5	phosphoesterase PA-phosphatase related protein
A359_RS00040	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
A359_RS00055	ENOG4105VQ7	Rod shape-determining protein MreD
A359_RS00060	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
A359_RS00065	ENOG4105DFF	Rod shape-determining protein mreb
A359_RS00085	ENOG4105D3R	alkyl hydroperoxide reductase
A359_RS00095	ENOG4108ZAI	phosphatidylglycerophosphatase a
A359_RS00100	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
A359_RS00105	ENOG4107YIM	Involved in the transcription termination process (By similarity)
A359_RS00110	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
A359_RS00115	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
A359_RS00125	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A359_RS00130	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A359_RS00135	ENOG4105VIE	preprotein translocase, subunit YajC
A359_RS00140	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
A359_RS00145	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
A359_RS00155	ENOG410814C	multidrug resistance protein
A359_RS00160	ENOG4108MK9	spermidine N(1)-acetyltransferase
A359_RS00165	ENOG410814C	multidrug resistance protein
A359_RS00170	ENOG4105FE9	pseudouridine synthase
A359_RS00175	ENOG4105UBK	short-chain dehydrogenase reductase
A359_RS00180	ENOG4105C1A	potassium transporter peripheral membrane
A359_RS00185	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
A359_RS00190	ENOG4108M8S	permease YjgP YjgQ family protein
A359_RS00195	ENOG4108K5H	permease YjgP YjgQ family protein
A359_RS00205	ENOG4105CVI	Transcriptional regulator
A359_RS00220	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
A359_RS00225	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
A359_RS00230	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
A359_RS00240	ENOG4105CWC	Acetylornithine deacetylase
A359_RS00245	ENOG4105CH7	arginosuccinase
A359_RS00250	ENOG4105VEQ	Cold shock protein
A359_RS00255	ENOG4105D9M	gamma-glutamylcysteine synthetase
A359_RS00260	ENOG4107VXZ	Hydrolase
A359_RS00265	ENOG4105K63	Thioredoxin
A359_RS00275	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
A359_RS00280	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
A359_RS00285	ENOG4105C7S	Dehydrogenase
A359_RS00295	ENOG4105C72	UPF0176 protein
A359_RS00305	ENOG4105C6K	Malic enzyme
A359_RS00310	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
A359_RS00315	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
A359_RS00320	ENOG41076HS	cation diffusion facilitator family transporter
A359_RS00325	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
A359_RS00335	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
A359_RS00340	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
A359_RS00355	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
A359_RS00360	ENOG4105HFZ	Membrane
A359_RS00365	ENOG4105C1J	atp-dependent rna helicase
A359_RS00370	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
A359_RS00375	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
A359_RS00385	ENOG4108Z6B	deaminase
A359_RS00395	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A359_RS00405	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
A359_RS00410	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
A359_RS00420	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
A359_RS00425	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
A359_RS00430	ENOG4105C3Q	Glycosyl transferase, family 2
A359_RS00445	ENOG4105JRK	feS assembly protein SufD
A359_RS00450	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
A359_RS00460	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
A359_RS00465	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A359_RS00470	ENOG41075W9	High frequency lysogenization protein HflD homolog
A359_RS00475	ENOG4107QTF	adenylosuccinate lyase
A359_RS00490	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
A359_RS00495	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A359_RS00500	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A359_RS00505	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
A359_RS00510	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A359_RS00520	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
A359_RS00525	ENOG4107R11	Transcriptional regulator
A359_RS00530	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
A359_RS00540	ENOG4105C34	Pseudouridine synthase
A359_RS00545	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A359_RS00550	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
A359_RS00555	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
A359_RS00560	ENOG4105CAT	Cytidine monophosphate kinase
A359_RS00565	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
A359_RS00585	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
A359_RS00590	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
A359_RS00595	ENOG4105C4R	Atp-dependent dna helicase
A359_RS00600	ENOG4107QUT	magnesium and cobalt transport protein CorA
A359_RS00605	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
A359_RS00610	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
A359_RS00615	ENOG4105C11	sulfate adenylyltransferase), subunit 2
A359_RS00620	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
A359_RS00625	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
A359_RS00630	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
A359_RS00635	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
A359_RS00640	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
A359_RS00645	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
A359_RS00650	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
A359_RS00655	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
A359_RS00675	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
A359_RS00685	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
A359_RS00690	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
A359_RS00695	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
A359_RS00700	ENOG41082NX	50s ribosomal protein l35
A359_RS00705	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
A359_RS00710	ENOG4105C22	threonyL-tRNA synthetase
A359_RS00720	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
A359_RS00725	ENOG4107RZZ	dna polymerase iii epsilon subunit
A359_RS00730	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
A359_RS00735	ENOG4105D1A	Methyltransferase
A359_RS00740	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
A359_RS00745	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
A359_RS00750	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
A359_RS00755	ENOG4105C75	arginyL-tRNA synthetase
A359_RS00760	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
A359_RS00765	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
A359_RS00780	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
A359_RS00785	ENOG4105M2J	Glutaredoxin
A359_RS00790	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
A359_RS00805	ENOG4105CJR	Integral membrane protein (MviN
A359_RS00810	ENOG4105CUG	Oligopeptidase b
A359_RS00820	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
A359_RS00825	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
A359_RS00830	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
A359_RS00835	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
A359_RS00840	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
A359_RS00850	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
A359_RS00855	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
A359_RS00870	ENOG4105CSM	endonuclease III
A359_RS00880	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
A359_RS00885	ENOG4105C5S	asparaginyl-tRNA synthetase
A359_RS00895	ENOG4105C5X	domain protein
A359_RS00900	ENOG4105EUJ	GTP cyclohydrolase i
A359_RS00910	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
A359_RS00915	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
A359_RS00920	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
A359_RS00925	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
A359_RS00930	ENOG4105D7W	serine acetyltransferase
A359_RS00935	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
A359_RS00940	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
A359_RS00945	ENOG4107YZP	Rhodanese domain protein
A359_RS00950	ENOG4107QNK	)-transporter
A359_RS00960	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
A359_RS00965	ENOG4108535	NAD dependent epimerase/dehydratase family
A359_RS00970	ENOG4105D07	Signal peptide peptidase, SppA
A359_RS00980	ENOG4108EF9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
A359_RS00985	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
A359_RS00990	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
A359_RS01000	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
A359_RS01005	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
A359_RS01010	ENOG4105CPF	Cell wall formation (By similarity)
A359_RS01015	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
A359_RS01020	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
A359_RS01025	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
A359_RS01035	ENOG4108R6K	riboflavin synthase, subunit alpha
A359_RS01040	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
A359_RS01045	ENOG4105W0Z	cytoplasmic protein
A359_RS01050	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
A359_RS01060	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
A359_RS01065	ENOG4105QZ5	OriC-binding nucleoid-associated protein
A359_RS01075	ENOG4105CS9	pantothenic acid kinase
A359_RS01105	ENOG4105PM1	preprotein translocase subunit SecE
A359_RS01110	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
A359_RS01115	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
A359_RS01120	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
A359_RS01125	ENOG4108VZM	50s ribosomal protein L10
A359_RS01130	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
A359_RS01135	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A359_RS01140	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A359_RS01145	ENOG4105CJN	penicillin-binding protein
A359_RS01150	ENOG4105CNI	cell division protein FtsW
A359_RS01155	ENOG4108Z43	UPF0250 protein
A359_RS01160	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
A359_RS01165	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
A359_RS01175	ENOG4107R03	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
A359_RS01180	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
A359_RS01185	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A359_RS01190	ENOG4105DJ0	Poly(A) Polymerase
A359_RS01195	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A359_RS01200	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
A359_RS01205	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
A359_RS01210	ENOG4105EGS	Mechanosensitive ion channel
A359_RS01215	ENOG4105DJ4	phosphatidylserine decarboxylase
A359_RS01220	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
A359_RS01225	ENOG4105C9B	Cysteine desulfurase
A359_RS01230	ENOG4105JRK	feS assembly protein SufD
A359_RS01235	ENOG4105C3K	feS assembly ATPase SufC
A359_RS01240	ENOG4105DIW	FeS assembly protein SUFB
A359_RS01245	ENOG4108Z4V	iron-sulfur cluster assembly
A359_RS01250	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
A359_RS01255	ENOG4108ZT0	50S ribosomal protein l17
A359_RS01265	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
A359_RS01270	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
A359_RS01275	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A359_RS01280	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
A359_RS01285	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
A359_RS01290	ENOG4105VPB	50S ribosomal protein L30
A359_RS01295	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
A359_RS01300	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
A359_RS01305	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
A359_RS01310	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
A359_RS01315	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
A359_RS01320	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A359_RS01325	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
A359_RS01330	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
A359_RS01335	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
A359_RS01340	ENOG41083MP	50s ribosomal protein l29
A359_RS01345	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
A359_RS01350	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
A359_RS01360	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
A359_RS01365	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A359_RS01370	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
A359_RS01375	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
A359_RS01380	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
A359_RS01400	ENOG4105D52	delta-aminolevulinic acid dehydratase
A359_RS01405	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
A359_RS01415	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
A359_RS01420	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
A359_RS01425	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
A359_RS01435	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
A359_RS01450	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A359_RS01455	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
A359_RS01460	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
A359_RS01470	ENOG4105DFU	Cell wall formation (By similarity)
A359_RS01475	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
A359_RS01480	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
A359_RS01485	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
A359_RS01490	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
A359_RS01495	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
A359_RS01505	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
A359_RS01510	ENOG4107QYX	exodeoxyribonuclease v alpha
A359_RS01515	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
A359_RS01520	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
A359_RS01535	ENOG4105ECW	sulfate abc transporter
A359_RS01540	ENOG4108I5D	sulfate abc transporter
A359_RS01545	ENOG4108J2H	Sulfate ABC transporter periplasmic sulfate-binding protein
A359_RS01550	ENOG4105EE5	Membrane protein terC
A359_RS01555	ENOG4108EQA	pts system
A359_RS01560	ENOG4105ETZ	PTS System
A359_RS01565	ENOG4105F3R	pts system mannose fructose sorbose family iid
A359_RS01570	ENOG41077A9	carbonic anhydrase
A359_RS01575	ENOG4106W5V	Membrane
A359_RS01580	ENOG4105CV1	Transketolase (EC 2.2.1.1)
A359_RS01585	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
A359_RS01590	ENOG4108UPT	UPF0178 protein
A359_RS01600	ENOG41072GX	Peptidase M22 Glycoprotease
A359_RS01605	ENOG4105VEQ	Cold shock protein
A359_RS01620	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
A359_RS01625	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
A359_RS01630	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
A359_RS01635	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
A359_RS01640	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
A359_RS01650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
A359_RS01655	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
A359_RS01660	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
A359_RS01665	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
A359_RS01670	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
A359_RS01675	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
A359_RS01680	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
A359_RS01685	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
A359_RS01690	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A359_RS01695	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
A359_RS01700	ENOG41076E6	Uroporphyrinogen-III Synthase
A359_RS01715	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
A359_RS01720	ENOG4107RJ7	Glycosyl transferase (Group 1
A359_RS01725	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
A359_RS01735	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
A359_RS01740	ENOG4105W0E	50S ribosomal protein L33
A359_RS01745	ENOG4105KDC	50s ribosomal protein l28
A359_RS01750	ENOG4105E66	phosphoriboisomerase A
A359_RS01760	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
A359_RS01765	ENOG4105DAN	ATP-dependent protease
A359_RS01770	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
A359_RS01775	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A359_RS01785	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
A359_RS01790	ENOG41090BQ	Glutaredoxin
A359_RS01795	ENOG4106H78	methyltransferase
A359_RS01800	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
A359_RS01805	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
A359_RS01810	ENOG4105EAH	synthase
A359_RS01815	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
A359_RS01820	ENOG4105K46	50S ribosomal protein l27
A359_RS01830	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A359_RS01835	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
A359_RS01840	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
A359_RS01845	ENOG4108WPU	DNA polymerase III subunit psi
A359_RS01850	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
A359_RS01855	ENOG4105CPK	Glycosyl transferase (Group 1
A359_RS01870	ENOG4105C3G	gtp-binding protein
A359_RS01875	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
A359_RS01880	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
A359_RS01885	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
A359_RS01890	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
A359_RS01895	ENOG4107RNH	Outer membrane receptor FepA
A359_RS01905	ENOG4105DC1	bifunctional purine biosynthesis protein purh
A359_RS01910	ENOG4105C12	Phosphoribosylglycinamide synthetase
A359_RS01920	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
A359_RS01930	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
A359_RS01935	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
A359_RS01940	ENOG4105K8N	protein family UPF0079, ATPase
A359_RS01955	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
A359_RS01960	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
A359_RS01975	ENOG4107QJR	hflk protein
A359_RS01980	ENOG4105EPW	hflc protein
A359_RS01985	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
A359_RS01995	ENOG4105C2N	RNA methyltransferase TrmH family group 3
A359_RS02000	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
A359_RS02010	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
A359_RS02015	ENOG4105EEI	dihydropteroate synthase
A359_RS02020	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
A359_RS02035	ENOG4105CHV	Transcription elongation factor NusA
A359_RS02040	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
A359_RS02045	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
A359_RS02050	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
A359_RS02060	ENOG4105C3M	thioredoxin reductase
A359_RS02075	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
A359_RS02080	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
A359_RS02085	ENOG4105CXT	aspartate transcarbamylase
A359_RS02090	ENOG4105BZ1	(ABC) transporter
A359_RS02095	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
A359_RS02100	ENOG4105W49	UPF0434 protein
A359_RS02105	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
A359_RS02110	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
A359_RS02115	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
A359_RS02120	ENOG4105GSS	Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity)
A359_RS02125	ENOG4105W4M	Transport-associated protein
A359_RS02130	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
A359_RS02135	ENOG4105DJF	DNA polymerase III, delta' subunit
A359_RS02140	ENOG4108U2H	Rare lipoprotein B
A359_RS02145	ENOG4105C8T	Leucyl-tRNA synthetase
A359_RS02160	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
A359_RS02165	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A359_RS02170	ENOG4105C1J	atp-dependent rna helicase
A359_RS02175	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
A359_RS02180	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
A359_RS02185	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
A359_RS02190	ENOG4107QNK	)-transporter
A359_RS02195	ENOG4107RAQ	aminopeptidase
A359_RS02200	ENOG4105D0A	hydroxylase
A359_RS02205	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
A359_RS02210	ENOG4105CJB	Exodeoxyribonuclease I
A359_RS02215	ENOG4105DR5	peptidase
A359_RS02220	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
A359_RS02225	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
A359_RS02230	ENOG4105CFG	Acts as a chaperone (By similarity)
A359_RS02235	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
A359_RS02245	ENOG4105DTN	riboflavin biosynthesis protein ribF
A359_RS02250	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
A359_RS02255	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
A359_RS02260	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
A359_RS02265	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
A359_RS02270	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
A359_RS02275	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
A359_RS02280	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
A359_RS02285	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
A359_RS02295	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
A359_RS02300	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
A359_RS02305	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
A359_RS02310	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
A359_RS02315	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
A359_RS02320	ENOG4105CJ3	phosphate transporter
A359_RS02325	ENOG4107QP8	phosphohexose isomerase
A359_RS02330	ENOG4105C9M	aspartyl-trna synthetase
A359_RS02335	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
A359_RS02340	ENOG4107QSN	dihydrolipoamide acetyltransferase
A359_RS02345	ENOG4107QN2	dihydrolipoyl dehydrogenase
A359_RS02350	ENOG4108ZNX	Heat shock protein
A359_RS02365	ENOG4105CFH	Aspartokinase
A359_RS02370	ENOG4105MYN	Zinc uptake regulation protein
A359_RS02375	ENOG4108S3I	UPF0259 membrane protein
A359_RS02380	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
A359_RS02390	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
A359_RS02400	ENOG4108TEB	UPF0114 protein
A359_RS02405	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A359_RS02410	ENOG4105C8S	subunit m
A359_RS02415	ENOG4105D65	subunit l
A359_RS02420	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A359_RS02425	ENOG4107UFS	subunit j
A359_RS02430	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A359_RS02435	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
A359_RS02440	ENOG4107R0R	NADH dehydrogenase subunit g
A359_RS02445	ENOG4107QIZ	NADH dehydrogenase
A359_RS02450	ENOG4105GKE	subunit e
A359_RS02455	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A359_RS02460	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
A359_RS02465	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A359_RS02470	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
A359_RS02475	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
A359_RS02485	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
A359_RS02490	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
A359_RS02495	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
A359_RS02500	ENOG4105CX6	glutaminyL-tRNA synthetase
A359_RS02525	ENOG4107MKT	Stringent starvation protein a
A359_RS02530	ENOG4105KB2	stringent starvation protein b
A359_RS02535	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
A359_RS02540	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
A359_RS02545	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
A359_RS02555	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
A359_RS02560	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
A359_RS02565	ENOG4105E96	Colicin v production protein
A359_RS02570	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
A359_RS02575	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
A359_RS02580	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
A359_RS02585	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
A359_RS02615	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
A359_RS02620	ENOG4105C8N	cysteinyl-tRNA synthetase
A359_RS02625	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
A359_RS02630	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
A359_RS02635	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
A359_RS02640	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
A359_RS02645	ENOG4105E02	MotA TolQ exbB proton channel
A359_RS02650	ENOG4105M8F	Biopolymer transport protein exbD tolR
A359_RS02660	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
A359_RS02665	ENOG4105KCK	Peptidoglycan-associated lipoprotein
A359_RS02675	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A359_RS02680	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
A359_RS02685	ENOG4105VCC	30S ribosomal protein S21
A359_RS02695	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
A359_RS02700	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
A359_RS02705	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
A359_RS02710	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
A359_RS02715	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A359_RS02720	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A359_RS02725	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
A359_RS02730	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
A359_RS02735	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
A359_RS02740	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
A359_RS02745	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A359_RS02750	ENOG4108NE3	Salt-induced outer membrane protein
A359_RS02760	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
A359_RS02765	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A359_RS02770	ENOG4105C8V	SAICAR synthetase
A359_RS02775	ENOG4105D2N	Aldolase
A359_RS02780	ENOG4105BZA	Phosphoglycerate kinase
A359_RS02790	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
A359_RS02800	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
A359_RS02805	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A359_RS02810	ENOG4105E55	glycerol-3-phosphate acyltransferase
A359_RS02820	ENOG4105VG0	50S ribosomal protein l34
A359_RS02825	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
A359_RS02830	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
A359_RS02835	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
A359_RS02840	ENOG4107QKA	exodeoxyribonuclease V beta
A359_RS02850	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A359_RS02855	ENOG4107ZVW	dihydroneopterin aldolase
A359_RS02865	ENOG4105DSY	exodeoxyribonuclease V, gamma
A359_RS02870	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
A359_RS02875	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
A359_RS02910	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
A359_RS02915	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
A359_RS02920	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
A359_RS02925	ENOG4105CE9	30S ribosomal protein S2
A359_RS02930	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
A359_RS02935	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
A359_RS02940	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
A359_RS02945	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
A359_RS02970	ENOG4105CDU	Replicative dna helicase
A359_RS02995	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
A359_RS03010	ENOG4105KZ7	phosphocarrier protein hpr
A359_RS03015	ENOG4105C6T	cysteine synthase
A359_RS03020	ENOG4105CP7	Triose-phosphate isomerase
A359_RS03030	ENOG4105DP0	ferredoxin-NADP reductase
A359_RS03060	ENOG4108JA2	transcriptioN-repair coupling factor
A359_RS03065	ENOG4105D60	lipoprotein releasing system transmembrane protein
A359_RS03070	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A359_RS03075	ENOG4105D60	lipoprotein releasing system transmembrane protein
A359_RS03090	ENOG4105C5H	ABC transporter
A359_RS03095	ENOG4107VZS	Nicotinamide-nucleotide adenylyltransferase
A359_RS03105	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
A359_RS03110	ENOG41082NP	Multiple antibiotic resistance
A359_RS03115	ENOG4105DBV	ornithine carbamoyltransferase
A359_RS03130	ENOG4105MYG	DNA polymerase iii, chi subunit
A359_RS03140	ENOG4105D16	lipopolysaccharide heptosyltransferase i
A359_RS03145	ENOG4105XA0	heptosyltransferase ii
A359_RS03150	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
A359_RS03160	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
A359_RS03165	ENOG4105CKK	Glycosyl transferase, family 2
A359_RS03170	ENOG4105C3I	Nad-dependent epimerase dehydratase
A359_RS03175	ENOG4105F73	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
A359_RS03180	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
A359_RS03185	ENOG41060GT	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity)
A359_RS03190	ENOG4105PE8	Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity)
A359_RS03215	ENOG4107QYG	anthranilate phosphoribosyltransferase
A359_RS03220	ENOG4105DK0	Indole-3-glycerol phosphate synthase
A359_RS03225	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A359_RS03230	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
A359_RS03235	ENOG4108UUM	single-stranded DNA-binding protein
A359_RS03250	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A359_RS03280	ENOG4105DJV	ribulose-phosphate 3-epimerase
A359_RS03285	ENOG4105C31	Tryptophanyl-tRNA synthetase
A359_RS03290	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
A359_RS03300	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
A359_RS03305	ENOG4105C3F	Signal peptidase i
A359_RS03310	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
A359_RS03320	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
A359_RS03325	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
A359_RS03335	ENOG4105C0H	protease
A359_RS03340	ENOG4108W2Q	Cytochrome d ubiquinol oxidase subunit III
A359_RS03355	ENOG4105C9X	ppx gppa phosphatase
A359_RS03360	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
A359_RS03365	ENOG4105CA9	Pyruvate kinase
A359_RS03370	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
A359_RS03375	ENOG4105EKE	dihydroorotase
A359_RS03380	ENOG4107QQB	Ribonuclease E
A359_RS03390	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
A359_RS03395	ENOG4105C25	Primosomal protein n'
A359_RS03400	ENOG4105VFB	Binds the 23S rRNA (By similarity)
A359_RS03410	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
A359_RS03415	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
A359_RS03425	ENOG4105D9N	nucleoside
A359_RS03435	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
A359_RS03450	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
A359_RS03455	ENOG4105DIK	(ABC) transporter
A359_RS03460	ENOG4105CC5	ABC transporter
A359_RS03465	ENOG4105DSE	periplasmic solute binding protein
A359_RS03470	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
A359_RS03475	ENOG4108UJD	30S ribosomal protein S9
A359_RS03485	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
A359_RS03500	ENOG4108WEF	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)
A359_RS03505	ENOG4105K59	histidine triad (HIT) protein
A359_RS03510	ENOG4105F8V	Hydrolase, tatD family
A359_RS03515	ENOG4107QRG	dna polymerase iii
A359_RS03520	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
A359_RS03535	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
A359_RS03540	ENOG4105CHR	reductase
A359_RS03545	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
A359_RS03550	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
A359_RS03555	ENOG4105VGS	50s ribosomal protein l32
A359_RS03560	ENOG4105CFU	surface antigen
A359_RS03565	ENOG4105MA0	exported protein
A359_RS03570	ENOG4105F0N	pyrophosphate phospho-hydrolase
A359_RS03575	ENOG4105EI2	Pseudouridine synthase
A359_RS03590	ENOG4105C3J	Cysteine desulfurase
A359_RS03595	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
A359_RS03600	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
A359_RS03605	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A359_RS03610	ENOG4105CUT	histidyl-tRNA synthetase
A359_RS03615	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
A359_RS03635	ENOG4105CSA	Coproporphyrinogen iii oxidase
A359_RS03640	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
A359_RS03645	ENOG4108VIA	integral membrane protein
A359_RS03650	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
A359_RS03655	ENOG4105CEN	a g-specific adenine glycosylase
A359_RS03660	ENOG4108Z1B	Cyclase dehydrase
A359_RS03665	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
A359_RS03670	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
A359_RS03675	ENOG4105DGW	oligopeptidase A
A359_RS03680	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
A359_RS03685	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
A359_RS03690	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
A359_RS03695	ENOG4105JC1	sterol-binding domain protein
A359_RS03700	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
A359_RS03705	ENOG4105CGY	Dna recombination protein
A359_RS03710	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
A359_RS03715	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
A359_RS03725	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
A359_RS03730	ENOG4105EST	Metal Dependent Phosphohydrolase
A359_RS03740	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
A359_RS03745	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
A359_RS03750	ENOG4105K5M	30s ribosomal protein S16
A359_RS03755	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A359_RS03760	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
A359_RS03765	ENOG4105VFK	BolA family
A359_RS03770	ENOG4105C2X	Arabinose 5-phosphate isomerase
A359_RS03780	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
A359_RS03785	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
A359_RS03790	ENOG4108IUZ	ABC transporter
A359_RS03795	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
A359_RS03800	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
A359_RS03805	ENOG4105CTB	Polyprenyl synthetase
A359_RS03810	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
A359_RS03815	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
A359_RS03825	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
A359_RS03830	ENOG4105CCU	oxidase (Subunit III)
A359_RS03835	ENOG4105BZ9	Cytochrome C oxidase, subunit I
A359_RS03840	ENOG4105E2S	oxidase) subunit II
A359_RS03855	ENOG4105CRK	lysyL-tRNA synthetase
A359_RS03865	ENOG4105CHC	glucokinase (EC 2.7.1.2)
A359_RS03870	ENOG4105C2M	dna polymerase I
A359_RS03875	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
A359_RS03880	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
A359_RS03895	ENOG41090A1	ferritin
A359_RS03905	ENOG4105D7Z	glutathione synthase
A359_RS03915	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
A359_RS03920	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
A359_RS03925	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
A359_RS03930	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
A359_RS03945	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
A359_RS03965	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
A359_RS03970	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
A359_RS03975	ENOG4107TH8	cina domain protein
A359_RS03980	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
A359_RS03990	ENOG4105D0M	Protease HtpX homolog
A359_RS03995	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
A359_RS04000	ENOG4105JIM	Phosphatidylserine synthase
A359_RS04010	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
A359_RS04015	ENOG4105KNE	Phosphatidate cytidylyltransferase
A359_RS04020	ENOG4105DZP	Membrane-associated zinc metalloprotease
A359_RS04025	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A359_RS04030	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
A359_RS04035	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A359_RS04040	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
A359_RS04045	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A359_RS04050	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
A359_RS04055	ENOG4105C0B	DNA polymerase III (alpha subunit)
A359_RS04060	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
A359_RS04075	ENOG4105CTQ	phosphohexokinase
A359_RS04080	ENOG4105C6X	Major Facilitator
A359_RS04085	ENOG4105BZ4	penicillin-binding protein
A359_RS04090	ENOG4105M85	Bola protein
A359_RS04095	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
A359_RS04105	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
A359_RS04110	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A359_RS04115	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
A359_RS04165	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
A359_RS04175	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
A359_RS04185	ENOG4107RDB	Major Facilitator
A359_RS04215	ENOG4105X5C	UPF0181 protein
A359_RS04225	ENOG41067V7	50S ribosomal protein L36
A359_RS04235	ENOG4107QMP	dna polymerase iii subunits gamma and tau
A359_RS04245	ENOG4105CE1	Ferrous iron transport protein b
A359_RS04275	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
A359_RS04280	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha