locus_tag old_locus_tag gene Name start end strand product note type ID NCBI A35E_RS00005 A35E_00001 dnaA dnaA 1 1410 + chromosomal replication initiator protein DnaA binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication%3B can also affect transcription of multiple genes including itself. gene gene0 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00005 A35E_RS00010 A35E_00002 A35E_RS00010 1413 2513 + DNA polymerase III subunit beta binds the polymerase to DNA and acts as a sliding clamp gene gene1 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00010 A35E_RS00015 A35E_00003 A35E_RS00015 3385 3810 - MarR family transcriptional regulator gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00015 A35E_RS00020 A35E_00004 A35E_RS00020 5816 7552 - glutathione ABC transporter ATP-binding protein in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance%3B important for cytochrome bd and c gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00020 A35E_RS00025 A35E_00005 A35E_RS00025 7573 9324 - amino acid ABC transporter permease in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance%3B important for cytochrome bd and c gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00025 A35E_RS00030 A35E_00006 A35E_RS00030 11209 11712 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00030 A35E_RS00035 A35E_00007 pcnB pcnB 11713 13008 - poly(A) polymerase I Polymerase that creates the 3' poly(A) tail found in some mRNA's gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00035 A35E_RS00040 A35E_00008 A35E_RS00040 14318 15319 - membrane protein gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00040 A35E_RS00045 A35E_00009 A35E_RS00045 16902 18659 + aspartyl-tRNA synthetase gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00045 A35E_RS00050 A35E_00010 A35E_RS00050 19735 19822 - tRNA-Ser tRNA gene9 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00050 A35E_RS00055 A35E_00013 glmU glmU 30119 31495 + bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase forms a homotrimer%3B catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc%3B function in cell wall synthesis gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00055 A35E_RS00060 A35E_00014 A35E_RS00060 31648 33480 + glucosamine--fructose-6-phosphate aminotransferase Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00060 A35E_RS00065 A35E_00015 A35E_RS00065 35086 36168 + hypothetical protein gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00065 A35E_RS00070 A35E_00016 rpmA rpmA 37223 37480 - 50S ribosomal protein L27 involved in the peptidyltransferase reaction during translation gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00070 A35E_RS00075 A35E_00017 rplU rplU 37485 37808 - 50S ribosomal protein L21 gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00075 A35E_RS00080 A35E_00018 hslU hslU 38956 40287 - ATP-dependent protease heat shock protein involved in degradation of misfolded proteins gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00080 A35E_RS00085 A35E_00019 A35E_RS00085 40280 40828 - ATP-dependent protease heat shock protein involved in degradation of misfolded proteins gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00085 A35E_RS00090 A35E_00020 A35E_RS00090 43377 44237 - RNA polymerase factor sigma-32 binds with the catalytic core of RNA polymerase to produce the holoenzyme%3B this sigma factor is responsible for the expression of heat shock promoters gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00090 A35E_RS00095 A35E_00021 A35E_RS00095 45305 46057 - outer membrane biogenesis protein BamD gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00095 A35E_RS00100 A35E_00022 rluD rluD 46188 47135 + ribosomal large subunit pseudouridine synthase D responsible for synthesis of pseudouridine from uracil at positions 1911%2C 1915 and 1917 in 23S ribosomal RNA gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00100 A35E_RS00105 A35E_00023 ligA ligA 48518 50569 - NAD-dependent DNA ligase LigA this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction%3B essential for DNA replication and repair of damaged DNA%3B similar to ligase LigB gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00105 A35E_RS00115 A35E_00025 cmk cmk 53071 53778 + cytidylate kinase Catalyzes the formation of (d)CDP from ATP and (d)CMP gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00115 A35E_RS00120 A35E_00026 rpsA rpsA 53878 55557 + 30S ribosomal protein S1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit%3B autoregulates expression via a C-terminal domain%3B in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats%3B the S1 nucleic acid-binding domain is found associated with other proteins gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00120 A35E_RS00125 A35E_00027 ihfB ihfB 55644 55925 + integration host factor subunit beta This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00125 A35E_RS00130 A35E_00028 A35E_RS00130 56801 57571 - hypothetical protein gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00130 A35E_RS00135 A35E_00029 A35E_RS00135 58827 59816 - 6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00135 A35E_RS00140 A35E_RS00140 A35E_RS00140 59808 60089 + hypothetical protein gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00140 A35E_RS00145 A35E_00030 A35E_RS00145 60668 61201 - membrane protein gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00145 A35E_RS00150 A35E_00031 A35E_RS00150 62746 63783 - GMP reductase catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00150 A35E_RS00155 A35E_00032 A35E_RS00155 64955 65569 - GTP-binding protein gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00155 A35E_RS00160 A35E_00033 A35E_RS00160 70030 70980 + magnesium/nickel/cobalt transporter CorA responsible for the influx of magnesium ions gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00160 A35E_RS00165 A35E_00034 A35E_RS00165 74543 74615 + tRNA-Ala tRNA gene32 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00165 A35E_RS00170 A35E_00035 obgE obgE 75234 76235 - GTPase CgtA ObgE%3B essential GTPase%3B exhibits high exchange rate for GTP/GDP%3B associates with 50S ribosomal subunit%3B involved in regulation of chromosomal replication gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00170 A35E_RS00175 A35E_00036 A35E_RS00175 78037 78681 + superoxide dismutase SodA%3B manganese binding%3B only present under aerobic conditions%3B destroys free radicals gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00175 A35E_RS00180 A35E_00037 A35E_RS00180 79435 80301 - hypothetical protein gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00180 A35E_RS00185 A35E_00038 A35E_RS00185 81662 83713 + protease PtrB%3B oligopeptidase that cleaves peptide bonds following arginine and lysine residues gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00185 A35E_RS00190 A35E_00039 A35E_RS00190 84347 85708 - acetyl-CoA carboxylase biotin carboxylase subunit an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase%2C an enzyme that catalyzes the formation of malonyl-CoA%2C which in turn controls the rate of fatty acid metabolism gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00190 A35E_RS00195 A35E_00040 A35E_RS00195 85720 86178 - acetyl-CoA carboxylase gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00195 A35E_RS00200 A35E_00041 A35E_RS00200 87713 89284 + cytochrome BD oxidase subunit I part of the aerobic respiratory chain%3B catalyzes the ubiquinol to ubiquinone gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00200 A35E_RS00205 A35E_00042 A35E_RS00205 89300 90439 + cytochrome BD oxidase subunit II gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00205 A35E_RS00210 A35E_00043 ppnK ppnK 92083 92961 + inorganic polyphosphate/ATP-NAD kinase catalyzes the phosphorylation of NAD to NADP gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00210 A35E_RS00215 A35E_00044 A35E_RS00215 94028 94717 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaB gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00215 A35E_RS00220 A35E_00045 A35E_RS00220 98420 100285 - 1-deoxy-D-xylulose-5-phosphate synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00220 A35E_RS00230 A35E_00048 A35E_RS00230 102769 103602 - tryptophan synthase subunit alpha gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00230 A35E_RS00235 A35E_00049 A35E_RS00235 103602 104792 - tryptophan synthase subunit beta catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00235 A35E_RS00240 A35E_00050 A35E_RS00240 104834 106198 - phosphoribosylanthranilate isomerase monomeric bifunctional protein%3B functions in tryptophan biosynthesis pathway%3B phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00240 A35E_RS00245 A35E_00051 A35E_RS00245 106206 107204 - anthranilate phosphoribosyltransferase gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00245 A35E_RS00250 A35E_00053 A35E_RS00250 108970 109053 + tRNA-Leu tRNA gene49 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00250 A35E_RS00255 A35E_00054 znuB znuB 109828 110613 - zinc transporter involved in transport of zinc(II) with ZnuA and C gene gene50 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00255 A35E_RS00260 A35E_00055 znuC znuC 110685 111401 - Mn2+/Zn2+ABC transporter ATP-binding protein involved in transport of zinc(II) with ZnuA and C gene gene51 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00260 A35E_RS00265 A35E_00056 znuA znuA 111475 112458 + zinc ABC transporter substrate-binding protein involved in transport of zinc(II) with ZnuA and C gene gene52 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00265 A35E_RS00270 A35E_00057 A35E_RS00270 112458 113780 + peptidase gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00270 A35E_RS00275 A35E_00058 recD recD 114621 116489 - exonuclease V subunit alpha helicase/nuclease%3B with RecBC catalyzes the exonucleolytic cleavage of DNA%3B RecD has 5' to 3' helicase activity gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00275 A35E_RS00280 A35E_00059 recB recB 116523 120074 - exonuclease V subunit beta helicase/nuclease%3B with RecCD catalyzes the exonucleolytic cleavage of DNA%3B RecD has 5' to 3' helicase activity gene gene55 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00280 A35E_RS00285 A35E_00060 rsmD rsmD 124684 125301 - 16S rRNA methyltransferase catalyzes the methylation of 16S rRNA at position G966 gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00285 A35E_RS00290 A35E_00061 A35E_RS00290 126546 127184 + endonuclease IV DNA-(apurinic or apyrimidinic site) lyase%3B has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity%3B removed damaged DNA at cytosines%2C thymines and guanines gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00290 A35E_RS00295 A35E_00062 A35E_RS00295 127953 128570 - thymidine kinase catalyzes the formation of thymidine 5'-phosphate from thymidine gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00295 A35E_RS00300 A35E_00063 trxA trxA 129526 129852 + thioredoxin gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00300 A35E_RS00305 A35E_00065 A35E_RS00305 131706 132965 + signal recognition particle-docking protein FtsY gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00305 A35E_RS00310 A35E_00066 A35E_RS00310 132978 133646 + cell division protein FtsE ATP-binding protein of an ATP-binding cassette transporter%3B when bound to FtsX%2C FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00310 A35E_RS00315 A35E_00067 A35E_RS00315 133875 134642 + cell division protein gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00315 A35E_RS00320 A35E_00068 rpmG rpmG 134946 135113 - 50S ribosomal protein L33 in Escherichia coli BM108%2C a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function%3B there are paralogous genes in several bacterial genomes%2C and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31%3B the proteins in this group lack the CXXC motif gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00320 A35E_RS00325 A35E_00069 A35E_RS00325 135130 135375 - 50S ribosomal protein L28 gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00325 A35E_RS00330 A35E_00070 A35E_RS00330 143133 143843 + hydrolase gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00330 A35E_RS00335 A35E_00071 A35E_RS00335 145235 146182 - ribose-phosphate pyrophosphokinase catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00335 A35E_RS00340 A35E_RS00340 A35E_RS00340 146320 147167 - kinase gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00340 A35E_RS00345 A35E_00074 A35E_RS00345 147164 147799 - outer membrane lipoprotein LolB gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00345 A35E_RS00350 A35E_00075 A35E_RS00350 148633 149487 - 2-dehydro-3-deoxyphosphooctonate aldolase catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00350 A35E_RS00355 A35E_00076 cvrA cvrA 151839 153566 + potassium:proton antiporter the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter%3B can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00355 A35E_RS00360 A35E_RS00360 A35E_RS00360 154993 156994 + excinuclease ABC subunit B The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands%2C where it probes for the presence of a lesion gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00360 A35E_RS00365 A35E_00079 tppB tppB 157140 158624 - peptide ABC transporter permease mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium%3B member of proton-dependent oligopeptide transport (POT) system family%3B in Escherichia coli this gene is regulated by OmpR although not via osmoregulation gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00365 A35E_RS00370 A35E_00080 A35E_RS00370 159856 161211 - manganese transporter gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00370 A35E_RS00375 A35E_00081 A35E_RS00375 162722 163159 + hypothetical protein gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00375 A35E_RS00380 A35E_00082 A35E_RS00380 163180 163458 + glutaredoxin gene gene76 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00380 A35E_RS00385 A35E_00083 A35E_RS00385 163500 163958 + preprotein translocase subunit SecB molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm%3B in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA gene gene77 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00385 A35E_RS00390 A35E_00084 A35E_RS00390 163973 164989 + NAD(P)H-dependent glycerol-3-phosphate dehydrogenase gene gene78 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00390 A35E_RS00395 A35E_00085 A35E_RS00395 165723 166511 - enoyl-ACP reductase Catalyzes a key regulatory step in fatty acid biosynthesis gene gene79 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00395 A35E_RS00400 A35E_00086 coaD coaD 168206 168691 - phosphopantetheine adenylyltransferase Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA gene gene80 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00400 A35E_RS00405 A35E_00087 A35E_RS00405 170062 171792 + arginyl-tRNA synthetase gene gene81 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00405 A35E_RS00410 A35E_00088 coaE coaE 171855 172457 - dephospho-CoA kinase catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A%3B involved in coenzyme A biosynthesis gene gene82 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00410 A35E_RS00415 A35E_00089 A35E_RS00415 174208 174284 + tRNA-Asp tRNA gene83 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00415 A35E_RS00420 A35E_00090 A35E_RS00420 174293 174365 + tRNA-Trp tRNA gene84 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00420 A35E_RS00425 A35E_00091 A35E_RS00425 175584 175660 + tRNA-Ile tRNA gene85 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00425 A35E_RS00430 A35E_00092 A35E_RS00430 175809 175884 + tRNA-Ala tRNA gene86 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00430 A35E_RS00435 A35E_00093 A35E_RS00435 177443 177519 - tRNA-Thr tRNA gene87 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00435 A35E_RS00440 A35E_00094 A35E_RS00440 178879 179685 - hydrolase gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00440 A35E_RS00445 A35E_00095 A35E_RS00445 182173 183747 + phosphate transporter PitA involved in the transport of inorganic phosphate gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00445 A35E_RS00450 A35E_00096 A35E_RS00450 184919 186457 + membrane protein gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00450 A35E_RS00455 A35E_00097 A35E_RS00455 187862 188626 + triosephosphate isomerase Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00455 A35E_RS00460 A35E_00098 A35E_RS00460 190170 190388 - translation initiation factor IF-1 gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00460 A35E_RS00465 A35E_00099 A35E_RS00465 191519 192919 + asparaginyl-tRNA synthetase gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00465 A35E_RS00470 A35E_00100 A35E_RS00470 193388 193459 - tRNA-Gly tRNA gene94 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00470 A35E_RS00475 A35E_00101 A35E_RS00475 194342 196090 + hypothetical protein gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00475 A35E_RS00480 A35E_00102 A35E_RS00480 196135 199914 + hypothetical protein gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00480 A35E_RS00485 A35E_00103 A35E_RS00485 199957 200844 + 2-dehydropantoate 2-reductase ketopantoate reductase%3B catalyzes the NADPH reduction of ketopantoate to pantoate%3B functions in pantothenate (vitamin B5) biosynthesis gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00485 A35E_RS00490 A35E_00104 rfaD rfaD 202710 203648 + ADP-L-glycero-D-manno-heptose-6-epimerase catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00490 A35E_RS00495 A35E_00105 A35E_RS00495 203668 204705 + ADP-heptose--LPS heptosyltransferase catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00495 A35E_RS00500 A35E_00106 A35E_RS00500 204719 205723 + ADP-heptose--LPS heptosyl transferase gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00500 A35E_RS00505 A35E_00107 A35E_RS00505 207301 207789 - rod shape-determining protein MreD part of cell wall structural complex MreBCD%3B transmembrane component gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00505 A35E_RS00510 A35E_00108 A35E_RS00510 208050 208985 - rod shape-determining protein MreC gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00510 A35E_RS00515 A35E_00109 A35E_RS00515 209076 210119 - rod shape-determining protein Mbl gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00515 A35E_RS00520 A35E_00110 A35E_RS00520 211485 212174 + DnaA regulatory inactivator Hda controls initiation of DNA replication by inhibiting re-initiation of replication%2C promotes hydrolysis of DnaA-bound ATP gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00520 A35E_RS00525 A35E_RS00525 A35E_RS00525 213664 213981 - heat-shock protein HspQ gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00525 A35E_RS00530 A35E_00112 A35E_RS00530 215860 216810 + transaldolase gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00530 A35E_RS00535 A35E_00113 A35E_RS00535 216826 218826 + transketolase catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate%3B can transfer ketol groups between several groups%3B in Escherichia coli there are two tkt genes%2C tktA expressed during exponential growth and the tktB during stationary phase gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00535 A35E_RS00540 A35E_00114 A35E_RS00540 220542 221549 - tryptophanyl-tRNA synthetase gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00540 A35E_RS00545 A35E_00115 A35E_RS00545 223188 223787 + peptidyl-tRNA hydrolase Enables the recycling of peptidyl-tRNAs produced at termination of translation gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00545 A35E_RS00550 A35E_00116 ychF ychF 223874 224962 + GTP-binding protein EngD%3B translation-associated GTPase%3B the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3)%3B fluorescence spectroscopy revealed nucleic acid binding%3B the yeast protein YBR025c interacts with the translation elongation factor eEF1 gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00550 A35E_RS00555 A35E_00117 A35E_RS00555 226114 226881 + 3-deoxy-manno-octulosonate cytidylyltransferase CMP-2-keto-3-deoxyoctulosonic acid synthetase%3B catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00555 A35E_RS00560 A35E_00118 A35E_RS00560 227468 228292 + diadenosine tetraphosphatase gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00560 A35E_RS00565 A35E_00119 A35E_RS00565 229409 229741 + glutaredoxin gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00565 A35E_RS00570 A35E_00120 A35E_RS00570 230428 231105 - ribonuclease T Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00570 A35E_RS00575 A35E_00121 A35E_RS00575 232288 233850 - tRNA(Ile)-lysidine synthetase gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00575 A35E_RS00580 A35E_00122 murB murB 235705 236745 + UDP-N-acetylenolpyruvoylglucosamine reductase catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00580 A35E_RS00585 A35E_00123 A35E_RS00585 236742 237698 + bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor catalyzes the formation of biotinyl-5'-AMP%2C also acts as a transcriptional repressor of the biotin operon gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00585 A35E_RS00590 A35E_00124 A35E_RS00590 239085 240221 - molecular chaperone DnaJ chaperone Hsp40%3B co-chaperone with DnaK%3B Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C dnaK-independent fashion gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00590 A35E_RS00595 A35E_00125 dnaK dnaK 240299 242212 - molecular chaperone DnaK heat shock protein 70%3B assists in folding of nascent polypeptide chains%3B refolding of misfolded proteins%3B utilizes ATPase activity to help fold%3B co-chaperones are DnaJ and GrpE%3B multiple copies in some bacteria gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00595 A35E_RS00600 A35E_00126 rplI rplI 243977 244429 - 50S ribosomal protein L9 in Escherichia coli this protein is wrapped around the base of the L1 stalk gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00600 A35E_RS00605 A35E_00127 rpsR rpsR 244471 244698 - 30S ribosomal protein S18 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%3B helps stabilize the platform of the 30S subunit gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00605 A35E_RS00610 A35E_00128 A35E_RS00610 244703 245023 - primosomal replication protein N binds single-stranded DNA at the primosome assembly site gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00610 A35E_RS00615 A35E_00129 rpsF rpsF 245030 245422 - 30S ribosomal protein S6 binds cooperatively with S18 to the S15-16S complex%2C allowing platform assembly to continue with S11 and S21 gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00615 A35E_RS00620 A35E_00130 A35E_RS00620 249067 249141 + tRNA-Arg tRNA gene124 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00620 A35E_RS00625 A35E_00131 djlA djlA 250359 251180 - molecular chaperone DnaJ functions as a co-chaperone with DnaK%3B involved in regulation of colanic acid capsule%3B inner membrane protein%3B dimerized via transmembrane domain%3B J-like domain is cytoplasmic and can functionally substitute for DnaJ%3B stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00625 A35E_RS00630 A35E_00132 A35E_RS00630 251368 253704 + LPS assembly protein LptD is involved in outer membrane permeability gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00630 A35E_RS00635 A35E_00133 A35E_RS00635 253769 255064 + peptidyl-prolyl isomerase gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00635 A35E_RS00640 A35E_00134 pdxA pdxA 255057 256049 + 4-hydroxythreonine-4-phosphate dehydrogenase catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00640 A35E_RS00645 A35E_00135 ksgA ksgA 256036 256842 + dimethyladenosine transferase in Escherichia coli this enzyme catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA%3B mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin%3B members of this protein family have secondary functions gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00645 A35E_RS00650 A35E_00136 A35E_RS00650 257527 258426 - peptide chain release factor 2 catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00650 A35E_RS00655 A35E_00137 A35E_RS00655 260231 261265 - tRNA-dihydrouridine synthase A gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00655 A35E_RS00660 A35E_00138 A35E_RS00660 261579 264563 - 23S ribosomal RNA rRNA gene132 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00660 A35E_RS00665 A35E_00140 A35E_RS00665 266126 267112 - lysyl-tRNA synthetase poxA%3B regulates pyruvate oxidase poxB gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00665 A35E_RS00670 A35E_00141 A35E_RS00670 268375 269202 + glutamate racemase converts L-glutamate to D-glutamate%2C a component of peptidoglycan gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00670 A35E_RS00675 A35E_00142 A35E_RS00675 270434 273760 - mechanosensitive channel protein gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00675 A35E_RS00680 A35E_00143 A35E_RS00680 273792 274682 - phosphatidylserine decarboxylase gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00680 A35E_RS00685 A35E_00144 A35E_RS00685 277336 278559 + phosphopentomutase gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00685 A35E_RS00690 A35E_00145 deoD deoD 278672 279391 + purine nucleoside phosphorylase catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00690 A35E_RS00695 A35E_00146 A35E_RS00695 282940 283452 + hypothetical protein gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00695 A35E_RS00700 A35E_00147 A35E_RS00700 284665 285516 - GTPase Era gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00700 A35E_RS00705 A35E_00148 rnc rnc 285513 286193 - ribonuclease III cytoplasmic enzyme involved in processing rRNA and some mRNAs%3B substrates typically have dsRNA regions%3B forms a homodimer%3B have N-terminal nuclease and C-terminal RNA-binding domains%3B requires magnesium as preferred ion for activity gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00705 A35E_RS00710 A35E_00149 A35E_RS00710 286352 287347 - signal peptidase catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00710 A35E_RS00715 A35E_00150 A35E_RS00715 287363 289162 - elongation factor 4 gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00715 A35E_RS00720 A35E_00151 gltX gltX 291419 292843 + glutamate--tRNA ligase catalyzes a two-step reaction%2C first charging an glutamate molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B contains discriminating and non-discriminating subtypes gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00720 A35E_RS00725 A35E_00152 bioD bioD 295314 296006 + dithiobiotin synthetase DTB synthetase%3B dethiobiotin synthase%3B involved in production of dethiobiotin from ATP and 7%2C8-diaminononanoate and carbon dioxide%3B contains magnesium gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00725 A35E_RS00730 A35E_00153 A35E_RS00730 296993 298033 - biotin synthase catalyzes the formation of biotin from dethiobiotin gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00730 A35E_RS00735 A35E_00154 A35E_RS00735 299522 299608 + tRNA-Leu tRNA gene147 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00735 A35E_RS00740 A35E_00155 A35E_RS00740 301160 302491 + proline aminopeptidase P II exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue%3B substrate can be as short as a dipeptide gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00740 A35E_RS00745 A35E_00156 A35E_RS00745 304689 305321 + hypothetical protein gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00745 A35E_RS00750 A35E_00157 A35E_RS00750 306259 307173 + glycyl-tRNA synthetase subunit alpha gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00750 A35E_RS00755 A35E_00158 glyS glyS 307183 309258 + glycyl-tRNA synthetase glycine--tRNA ligase beta chain%3B glyS%3B class II aminoacyl tRNA synthetase%3B tetramer of alpha(2)beta(2)%3B catalyzes a two-step reaction%3B first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP%3B second by transfer of the aminoacyl-adenylate to its tRNA gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00755 A35E_RS00760 A35E_00159 A35E_RS00760 309767 310954 + nucleoside permease gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00760 A35E_RS00765 A35E_00160 A35E_RS00765 311968 313143 + S-adenosylmethionine synthetase catalyzes the formation of S-adenosylmethionine from methionine and ATP%3B methionine adenosyltransferase gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00765 A35E_RS00770 A35E_00161 A35E_RS00770 313905 313980 - tRNA-Val tRNA gene154 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00770 A35E_RS00775 A35E_00162 A35E_RS00775 314260 317058 - DNA polymerase I gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00775 A35E_RS00780 A35E_00163 A35E_RS00780 319245 321155 + hypothetical protein gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00780 A35E_RS00785 A35E_00164 A35E_RS00785 321797 322489 + YggS family pyridoxal phosphate enzyme gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00785 A35E_RS00790 A35E_00165 A35E_RS00790 323342 323896 + hypothetical protein gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00790 A35E_RS00795 A35E_00166 A35E_RS00795 324700 325830 + HemN family oxidoreductase gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00795 A35E_RS00800 A35E_00167 A35E_RS00800 325913 326239 - sulfur transfer protein TusE transfers sulfur from TusBCD complex to MnmA%3B involved in thiouridation of U34 position of some tRNAs gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00800 A35E_RS00805 A35E_00168 A35E_RS00805 327496 328041 + oligoribonuclease 3'-5' exoribonuclease specific for small oligoribonuclotides gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00805 A35E_RS00810 A35E_00169 A35E_RS00810 329728 330600 + acetyl-CoA carboxylase subunit beta catalyzes the carboxylation of acetyl-CoA to malonyl-CoA%3B forms a tetramer of AccA2D2 subunits gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00810 A35E_RS00815 A35E_00170 A35E_RS00815 330708 331994 + bifunctional folylpolyglutamate synthase/ dihydrofolate synthase gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00815 A35E_RS00820 A35E_00171 A35E_RS00820 332595 333197 + peroxiredoxin gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00820 A35E_RS00825 A35E_00172 groEL groEL 333405 335054 - molecular chaperone GroEL 60 kDa chaperone family%3B promotes refolding of misfolded polypeptides especially under stressful conditions%3B forms two stacked rings of heptamers to form a barrel-shaped 14mer%3B ends can be capped by GroES%3B misfolded proteins enter the barrel where they are refolded when GroES binds%3B many bacteria have multiple copies of the groEL gene which are active under different environmental conditions%3B the B.japonicum protein in this cluster is expressed constitutively%3B in Rhodobacter%2C Corynebacterium and Rhizobium this protein is essential for growth gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00825 A35E_RS00830 A35E_00173 groES groES 335102 335395 - molecular chaperone GroES 10 kDa chaperonin%3B Cpn10%3B GroES%3B forms homoheptameric ring%3B binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it%3B folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES%3B release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00830 A35E_RS00835 A35E_00174 A35E_RS00835 336613 337539 - lipid A biosynthesis lauroyl acyltransferase Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00835 A35E_RS00840 A35E_00175 A35E_RS00840 338026 338535 - colicin V production protein membrane protein required for colicin V production gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00840 A35E_RS00845 A35E_00176 A35E_RS00845 339241 340677 - bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D%2CD-heptose-1%2C7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D%2CD-heptose gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00845 A35E_RS00850 A35E_00177 ribB ribB 341906 342559 - 3%2C4-dihydroxy-2-butanone 4-phosphate synthase DHBP synthase%3B functions during riboflavin biosynthesis gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00850 A35E_RS00855 A35E_00178 pgi pgi 345063 346709 + glucose-6-phosphate isomerase functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis%3B catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate%3B member of PGI family gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00855 A35E_RS00860 A35E_00179 A35E_RS00860 348478 350370 + heat-shock protein Hsp90 molecular chaperone gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00860 A35E_RS00865 A35E_00180 adk adk 350654 351298 + adenylate kinase essential enzyme that recycles AMP in active cells%3B converts ATP and AMP to two molecules of ADP gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00865 A35E_RS00870 A35E_00181 guaA guaA 352949 354529 + GMP synthase contains glutamine-hydrolyzing domain and glutamine amidotransferase%3B GMP-binding domain%3B functions to produce GMP from XMP in the IMP pathway gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00870 A35E_RS00875 A35E_00182 A35E_RS00875 354864 355814 - 23S rRNA pseudouridylate synthase C catalyzes the transformation of uracil to pseudouracil at nucleotides U955%2C U2504%2C and U2580 in 23S rRNA gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00875 A35E_RS00880 A35E_00183 A35E_RS00880 356409 358130 - prolyl-tRNA synthetase catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00880 A35E_RS00885 A35E_00184 prfC prfC 359623 361227 + peptide chain release factor 3 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred%3B GDP/GTP-binding protein gene gene177 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00885 A35E_RS00890 A35E_00185 A35E_RS00890 362716 363744 - EF-P beta-lysylation protein EpmB gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00890 A35E_RS00895 A35E_00186 A35E_RS00895 365083 366372 + adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7%2C8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00895 A35E_RS00900 A35E_00187 A35E_RS00900 366972 368255 - tyrosyl-tRNA synthetase gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00900 A35E_RS00905 A35E_00188 A35E_RS00905 368357 369007 - pyridoxamine 5'-phosphate oxidase catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00905 A35E_RS00910 A35E_00189 arnT arnT 371541 373184 - 4-amino-4-deoxy-L-arabinose transferase catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00910 A35E_RS00915 A35E_00190 A35E_RS00915 373181 374086 - 4-deoxy-4-formamido-L-arabinose-phospho-UDP deformylase catalyzes the formation of 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol from 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00915 A35E_RS00920 A35E_00191 A35E_RS00920 374083 376068 - bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase Bifunctional polymyxin resistance arnA protein%3B catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose%3B active in certain mutant strains gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00920 A35E_RS00925 A35E_00192 A35E_RS00925 376065 377045 - UDP phosphate 4-deoxy-4-formamido-L-arabinose transferase catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00925 A35E_RS00930 A35E_00194 A35E_RS00930 378929 379699 - LPS biosynthesis protein gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00930 A35E_RS00935 A35E_00195 A35E_RS00935 379711 380967 - 3-deoxy-D-manno-octulosonic acid transferase catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00935 A35E_RS00940 A35E_00196 A35E_RS00940 382102 383232 - glycosyl transferase family 1 gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00940 A35E_RS00945 A35E_00197 A35E_RS00945 384844 385272 - DNA polymerase III%2C psi subunit gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00945 A35E_RS00950 A35E_00198 A35E_RS00950 385567 386130 + 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase forms homotetramers%3B catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate%3B functions in lipopolysaccharide biosynthesis gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00950 A35E_RS00955 A35E_00199 A35E_RS00955 386127 386693 + LPS export ABC transporter periplasmic protein LptC gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00955 A35E_RS00960 A35E_00200 A35E_RS00960 386674 387183 + sugar ABC transporter substrate-binding protein LptA%3B periplasmic binding protein part of a putative ABC superfamily of uptake transporters%3B interacts with LptB protein%2C the ATP binding component of the uptake system gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00960 A35E_RS00965 A35E_00201 A35E_RS00965 387230 387955 + LPS export ABC transporter ATP-binding protein gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00965 A35E_RS00970 A35E_00202 acpS acpS 388108 388488 - 4'-phosphopantetheinyl transferase Catalyzes the formation of holo-ACP%2C which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00970 A35E_RS00975 A35E_00203 A35E_RS00975 388488 389219 - pyridoxine 5'-phosphate synthase involved in the de novo synthesis of pyridoxine (Vitamin B6) gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00975 A35E_RS00980 A35E_RS00980 A35E_RS00980 389793 389984 + hypothetical protein gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00980 A35E_RS00985 A35E_00204 A35E_RS00985 390081 391682 + L-aspartate oxidase catalyzes the formation of oxaloacetate from L-aspartate gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00985 A35E_RS00990 A35E_00205 A35E_RS00990 392608 393516 + recombinase Required for efficient pilin antigenic variation gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS00990 A35E_RS01000 A35E_00207 A35E_RS01000 399311 399652 + hypothetical protein gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01000 A35E_RS01005 A35E_00208 A35E_RS01005 401593 402012 - cysteine desufuration protein SufE Acts with SufS to catalyze the formation of L-alanine from L-cysteine gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01005 A35E_RS01010 A35E_00209 A35E_RS01010 402040 403266 - bifunctional cysteine desulfurase/selenocysteine lyase gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01010 A35E_RS01015 A35E_00210 A35E_RS01015 403263 404549 - Fe-S cluster assembly protein SufD gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01015 A35E_RS01020 A35E_00211 sufC sufC 404530 405270 - Fe-S cluster assembly ATPase SufC part of SUF system involved in inserting iron-sulfur clusters into proteins%3B in Escherichia coli this protein forms a complex with SufBD%3B the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01020 A35E_RS01025 A35E_00212 A35E_RS01025 405334 406842 - cysteine desulfurase activator complex subunit SufB with SufCD activates cysteine desulfurase SufS gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01025 A35E_RS01030 A35E_00213 sufA sufA 406856 407230 - (Fe-S)-cluster assembly protein functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]%3B [4Fe-4S]) are assembled%3B forms a homodimer%3B similar to IscA protein gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01030 A35E_RS01035 A35E_00214 A35E_RS01035 409545 410627 + LPS export ABC transporter permease LptF with LptBGC is involved in lipopolysaccharide export gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01035 A35E_RS01040 A35E_00215 A35E_RS01040 410646 411719 + LPS export ABC transporter permease LptG with LptABCF is involved in the transport of lipopolysaccharides gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01040 A35E_RS01045 A35E_00216 A35E_RS01045 412526 412601 + tRNA-Phe tRNA gene209 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01045 A35E_RS01050 A35E_00217 A35E_RS01050 414243 414500 + PTS sugar transporter gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01050 A35E_RS01055 A35E_00218 A35E_RS01055 414555 416282 + phosphoenolpyruvate-protein phosphotransferase Phosphotransferase system%2C enzyme I%3B transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein%3B part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active-transport system gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01055 A35E_RS01060 A35E_00219 A35E_RS01060 418505 419368 + hypothetical protein gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01060 A35E_RS01065 A35E_00220 cls cls 420892 422352 + cardiolipin synthase catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01065 A35E_RS01070 A35E_00221 nadE nadE 426871 427695 - NAD synthetase catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP%3B ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one%3B forms homodimers gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01070 A35E_RS01075 A35E_00222 A35E_RS01075 427768 428517 - 23S rRNA (guanosine-2'-O-)-methyltransferase Specifically methylates the ribose of guanosine 2251 in 23S rRNA gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01075 A35E_RS01080 A35E_00223 A35E_RS01080 429562 431877 - exoribonuclease R 3'-5'exoribonuclease that acts nonspecifically on poly(A)%2C poly(U) and ribosomal RNAs gene gene216 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01080 A35E_RS01085 A35E_00224 A35E_RS01085 433189 434487 - adenylosuccinate synthetase catalyzes the formation of N6-(1%2C2%2C-dicarboxyethyl)-AMP from L-aspartate%2C inosine monophosphate and GTP in AMP biosynthesis gene gene217 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01085 A35E_RS01090 A35E_00225 A35E_RS01090 436160 437179 - cell division protein FtsH with HflK inhibits proteolysis of lambda cII protein by FtsH gene gene218 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01090 A35E_RS01095 A35E_00226 A35E_RS01095 437182 438429 - cell division protein FtsH with HflC inhibits proteolysis of lambda cII protein by FtsH gene gene219 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01095 A35E_RS01100 A35E_00227 A35E_RS01100 440069 440374 - RNA chaperone Hfq gene gene220 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01100 A35E_RS01105 A35E_00228 miaA miaA 440490 441434 - tRNA dimethylallyltransferase IPP transferase%3B isopentenyltransferase%3B involved in tRNA modification%3B in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil%3B further tRNA modifications may occur%3B mutations in miaA result in defects in translation efficiency and fidelity gene gene221 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01105 A35E_RS01115 A35E_00230 A35E_RS01115 443833 445380 - N-acetylmuramoyl-L-alanine amidase gene gene223 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01115 A35E_RS01120 A35E_00231 A35E_RS01120 445398 445886 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaE gene gene224 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01120 A35E_RS01125 A35E_00232 A35E_RS01125 447871 447946 + tRNA-Lys tRNA gene225 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01125 A35E_RS01130 A35E_RS01130 A35E_RS01130 448487 449630 - hypothetical protein gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01130 A35E_RS01135 A35E_00237 fre fre 452855 453577 + FMN reductase NAD(P)H-flavin reductase%3B catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide%3B in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01135 A35E_RS01140 A35E_00238 A35E_RS01140 455138 456484 + signal recognition particle protein gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01140 A35E_RS01145 A35E_00239 A35E_RS01145 456598 456846 + 30S ribosomal protein S16 gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01145 A35E_RS01150 A35E_00240 rimM rimM 456866 457414 + 16S rRNA-processing protein M Essential for efficient processing of 16S rRNA gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01150 A35E_RS01155 A35E_00241 trmD trmD 457447 458190 + tRNA (guanine(37)-N(1))-methyltransferase methylates guanosine-37 in various tRNAs%3B uses S-adenosyl-L-methionine to transfer methyl group to tRNA gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01155 A35E_RS01160 A35E_00242 A35E_RS01160 458266 458613 + 50S ribosomal protein L19 gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01160 A35E_RS01165 A35E_00243 folA folA 459832 460320 + dihydrofolate reductase catalyzes the reduction of dihydrofolate to tetrahydrofolate gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01165 A35E_RS01170 A35E_00244 A35E_RS01170 463736 465214 - DNA recombination protein RmuC YigN%3B nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence%3B transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01170 A35E_RS01175 A35E_00245 A35E_RS01175 468920 469555 - membrane protein gene gene235 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01175 A35E_RS01180 A35E_00246 A35E_RS01180 470635 472059 - dihydrolipoamide dehydrogenase E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex%3B catalyzes the oxidation of dihydrolipoamide to lipoamide gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01180 A35E_RS01185 A35E_00247 A35E_RS01185 472309 473838 - dihydrolipoamide acetyltransferase gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01185 A35E_RS01190 A35E_00248 aceE aceE 473854 476520 - pyruvate dehydrogenase E1 component%3B part of pyruvate dehydrogenase%3B forms a complex with DlaT and LpdC gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01190 A35E_RS01195 A35E_00249 ribA ribA 479266 479865 - GTP cyclohydrolase II catalyzes the conversion of GTP to formate and 2%2C5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01195 A35E_RS01200 A35E_00250 A35E_RS01200 480127 480822 + phosphatidylglycerophosphatase B gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01200 A35E_RS01205 A35E_00252 A35E_RS01205 481733 482074 - Z-ring-associated protein gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01205 A35E_RS01210 A35E_00253 A35E_RS01210 483930 484679 + ferredoxin-NADP reductase gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01210 A35E_RS01215 A35E_00254 A35E_RS01215 485076 485321 - sulfurtransferase gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01215 A35E_RS01220 A35E_00255 A35E_RS01220 487004 487288 + 50S ribosomal protein L25 the Ctc family of proteins consists of two types%2C one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01220 A35E_RS01225 A35E_00256 A35E_RS01225 488836 489804 - sulfurtransferase gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01225 A35E_RS01230 A35E_00257 A35E_RS01230 491227 492669 - pyruvate kinase catalyzes the formation of phosphoenolpyruvate from pyruvate gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01230 A35E_RS01235 A35E_00258 A35E_RS01235 494364 495962 - heme ABC transporter ATP-binding protein gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01235 A35E_RS01240 A35E_00259 A35E_RS01240 503756 504967 + 3-oxoacyl-ACP synthase FabB%2C beta-Ketoacyl-ACP synthase I%2C KASI%3B catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP%3B required for the elongation of short-chain unsaturated acyl-ACP gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01240 A35E_RS01245 A35E_00260 A35E_RS01245 506555 507856 - aminopeptidase B catalyzes the removal of an N-terminal amino acid from a peptide or arylamide gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01245 A35E_RS01250 A35E_00261 A35E_RS01250 516169 517719 + 16S ribosomal RNA rRNA gene250 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01250 A35E_RS01255 A35E_00262 A35E_RS01255 517807 517881 + tRNA-Glu tRNA gene251 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01255 A35E_RS01260 A35E_00263 A35E_RS01260 518084 519388 - NADH dehydrogenase gene gene252 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01260 A35E_RS01265 A35E_00264 A35E_RS01265 521641 521907 + ferredoxin gene gene253 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01265 A35E_RS01270 A35E_00265 A35E_RS01270 522516 522591 + tRNA-Met tRNA gene254 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01270 A35E_RS01275 A35E_00266 A35E_RS01275 524889 526055 + phosphoglycerate kinase gene gene255 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01275 A35E_RS01280 A35E_00267 A35E_RS01280 526159 527235 + fructose-bisphosphate aldolase catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1%2C6%2C bisphosphate gene gene256 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01280 A35E_RS01285 A35E_00268 pssA pssA 527961 529316 - phosphatidylserine synthase catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine%3B bounds to the ribosome gene gene257 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01285 A35E_RS01290 A35E_00269 leuS leuS 530941 533532 + leucyl-tRNA synthetase leucine--tRNA ligase%3B LeuRS%3B class-I aminoacyl-tRNA synthetase%3B charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA%3B due to the large number of codons that tRNA(Leu) recognizes%2C the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA%2C but instead recognition is dependent on a conserved discriminator base A37 and a long arm%3B an editing domain hydrolyzes misformed products%3B in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase gene gene258 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01290 A35E_RS01295 A35E_00270 A35E_RS01295 533552 534085 + hypothetical protein rare lipoprotein B%3B involved in the assembly of LPS in the outer membrane gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01295 A35E_RS01300 A35E_00271 holA holA 534145 535179 + DNA polymerase III subunit delta required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01300 A35E_RS01305 A35E_00272 A35E_RS01305 535172 535828 + nicotinic acid mononucleotide adenylyltransferase gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01305 A35E_RS01310 A35E_00273 A35E_RS01310 537549 539429 + penicillin-binding protein 2 gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01310 A35E_RS01315 A35E_00274 A35E_RS01315 539460 540572 + cell wall shape-determining protein gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01315 A35E_RS01320 A35E_00275 A35E_RS01320 541607 544132 + DNA gyrase subunit A gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01320 A35E_RS01325 A35E_00276 A35E_RS01325 544228 544605 - 50S ribosomal protein L17 gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01325 A35E_RS01330 A35E_00277 A35E_RS01330 544640 545632 - DNA-directed RNA polymerase subunit alpha catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01330 A35E_RS01335 A35E_00278 A35E_RS01335 545658 546278 - 30S ribosomal protein S4 gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01335 A35E_RS01340 A35E_00279 A35E_RS01340 546308 546697 - 30S ribosomal protein S11 gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01340 A35E_RS01345 A35E_RS01345 A35E_RS01345 546719 547075 - 30S ribosomal protein S13 gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01345 A35E_RS01350 A35E_00282 A35E_RS01350 547222 547338 - 50S ribosomal protein L36 gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01350 A35E_RS01355 A35E_00283 secY secY 547372 548703 - preprotein translocase subunit SecY forms heterotrimeric complex in the membrane%3B in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG%3B the SecG subunit is not essential%3B in bacteria translocation is driven via the SecA ATPase gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01355 A35E_RS01360 A35E_00284 A35E_RS01360 548696 549145 - 50S ribosomal protein L15 gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01360 A35E_RS01365 A35E_00285 rpmD rpmD 549149 549328 - 50S ribosomal protein L30 L30 binds domain II of the 23S rRNA and the 5S rRNA%3B similar to eukaryotic protein L7 gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01365 A35E_RS01370 A35E_00286 A35E_RS01370 549336 549833 - 30S ribosomal protein S5 gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01370 A35E_RS01375 A35E_00287 A35E_RS01375 549850 550203 - 50S ribosomal protein L18 gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01375 A35E_RS01380 A35E_00288 A35E_RS01380 550213 550746 - 50S ribosomal protein L6 gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01380 A35E_RS01385 A35E_00289 A35E_RS01385 550762 551154 - 30S ribosomal protein S8 gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01385 A35E_RS01390 A35E_00290 rpsN rpsN 551189 551494 - 30S ribosomal protein S14 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit%3B similar to what is observed with proteins L31 and L33%2C some proteins in this family contain CXXC motifs that are involved in zinc binding%3B if two copies are present in a genome%2C then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc%3B the proteins in this group do not appear to have the zinc-binding motif gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01390 A35E_RS01395 A35E_00291 A35E_RS01395 551508 552047 - 50S ribosomal protein L5 gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01395 A35E_RS01400 A35E_00292 A35E_RS01400 552062 552376 - 50S ribosomal protein L24 gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01400 A35E_RS01405 A35E_00293 A35E_RS01405 552388 552756 - 50S ribosomal protein L14 gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01405 A35E_RS01410 A35E_00294 A35E_RS01410 552906 553160 - 30S ribosomal protein S17 gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01410 A35E_RS01415 A35E_00295 A35E_RS01415 553117 553350 - 50S ribosomal protein L29 one of the stabilizing components for the large ribosomal subunit gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01415 A35E_RS01420 A35E_00296 A35E_RS01420 553350 553760 - 50S ribosomal protein L16 gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01420 A35E_RS01425 A35E_00297 A35E_RS01425 553773 554471 - 30S ribosomal protein S3 gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01425 A35E_RS01430 A35E_00298 A35E_RS01430 554489 554821 - 50S ribosomal protein L22 gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01430 A35E_RS01435 A35E_00299 A35E_RS01435 554838 555116 - 30S ribosomal protein S19 gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01435 A35E_RS01440 A35E_00300 A35E_RS01440 555133 555957 - 50S ribosomal protein L2 gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01440 A35E_RS01445 A35E_00301 rplW rplW 555974 556276 - 50S ribosomal protein L23 binds third domain of 23S rRNA and protein L29%3B part of exit tunnel gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01445 A35E_RS01450 A35E_00302 rplD rplD 556273 556878 - 50S ribosomal protein L4 L4 is important during the early stages of 50S assembly%3B it initially binds near the 5' end of the 23S rRNA gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01450 A35E_RS01455 A35E_00303 A35E_RS01455 556895 557524 - 50S ribosomal protein L3 gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01455 A35E_RS01460 A35E_00304 rpsJ rpsJ 557560 557871 - 30S ribosomal protein S10 NusE%3B involved in assembly of the 30S subunit%3B in the ribosome%2C this protein is involved in the binding of tRNA%3B in Escherichia coli this protein was also found to be involved in transcription antitermination%3B NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination%3B binding of NusB/S10 to boxA nucleates assembly of the antitermination complex gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01460 A35E_RS01465 A35E_00305 rho rho 559276 560535 + transcription termination factor Rho An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01465 A35E_RS01470 A35E_00306 A35E_RS01470 564313 565434 + TDP-4-oxo-6-deoxy-D-glucose aminotransferase catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01470 A35E_RS01475 A35E_00307 A35E_RS01475 566821 567705 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01475 A35E_RS01480 A35E_00308 rpmH rpmH 568440 568583 + 50S ribosomal protein L34 in Escherichia coli transcription of this gene is enhanced by polyamines gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01480 A35E_RS01485 A35E_00309 rnpA rnpA 568602 568958 + ribonuclease P protein component protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus%3B this enzyme also cleaves other RNA substrates gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01485 A35E_RS01490 A35E_00311 A35E_RS01490 569192 570820 + membrane protein insertase functions to insert inner membrane proteins into the IM in Escherichia coli%3B interacts with transmembrane segments%3B functions in both Sec-dependent and -independent membrane insertion%3B similar to Oxa1p in mitochondria gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01490 A35E_RS01495 A35E_00312 trmE trmE 570938 572308 + tRNA modification GTPase TrmE in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine%2C which is found in the wobble position of some tRNAs and affects ribosomal frameshifting%3B shows potassium-dependent dimerization and GTP hydrolysis%3B also involved in regulation of glutamate-dependent acid resistance and activation of gadE gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01495 A35E_RS01500 A35E_00313 A35E_RS01500 572666 573421 - hydroxyacylglutathione hydrolase catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione%3B plays an important role in cellular detoxification using glutathione gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01500 A35E_RS01505 A35E_00314 folB folB 573913 574266 - dihydroneopterin triphosphate 2'-epimerase catalyzes the conversion of 7%2C8-dihydroneopterin to 6-hydroxymethyl-7%2C8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01505 A35E_RS01510 A35E_00315 lysS lysS 575033 576553 - lysyl-tRNA synthetase class II%3B LysRS2%3B catalyzes a two-step reaction%2C first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B in Methanosarcina barkeri%2C LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01510 A35E_RS01515 A35E_00316 gpmA gpmA 578780 579489 + phosphoglyceromutase 2%2C3-bisphosphoglycerate-dependent%3B catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01515 A35E_RS01520 A35E_00317 panC panC 581973 582827 - pantoate--beta-alanine ligase catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01520 A35E_RS01525 A35E_00318 panB panB 582848 583639 - 3-methyl-2-oxobutanoate hydroxymethyltransferase catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5%2C10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01525 A35E_RS01530 A35E_00319 A35E_RS01530 584889 585908 + tRNA threonylcarbamoyladenosine modification protein TsaD universal genome maintenance protein%3B Kae1/Qri7/OSGEP/YgjD family protein%3B in Archaea%2C some Kae1 are found as fusion proteins similar to two distinct proteins in yeast that are involved in the KEOPS complex%3B kinase associated endopeptidase 1 (Kae1) and a serine/threonine protein kinase (Bud32)%3B in Pyrococcus Kae1 has atypical AP endonuclease activity and inhibits the kinase activity of Bud32%3B the protein is essential in Escherichia coli and Bacillus subtilis gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01530 A35E_RS01535 A35E_00320 A35E_RS01535 587238 591461 - DNA-directed RNA polymerase subunit beta' DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01535 A35E_RS01540 A35E_00321 rpoB rpoB 591555 595583 - DNA-directed RNA polymerase subunit beta DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01540 A35E_RS01545 A35E_00323 A35E_RS01545 595910 596272 - 50S ribosomal protein L7/L12 gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01545 A35E_RS01550 A35E_00324 rplJ rplJ 596339 596836 - 50S ribosomal protein L10 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01550 A35E_RS01555 A35E_00325 A35E_RS01555 597146 597850 - 50S ribosomal protein L1 gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01555 A35E_RS01560 A35E_00326 A35E_RS01560 597834 598283 - 50S ribosomal protein L11 gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01560 A35E_RS01565 A35E_00327 nusG nusG 598433 598978 - transcription termination/antitermination factor NusG Modulates Rho-dependent transcription termination gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01565 A35E_RS01570 A35E_00328 secE secE 598980 599363 - preprotein translocase subunit SecE forms a complex with SecY and SecG%3B SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane%2C a process driven by ATP and a proton-motive force gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01570 A35E_RS01575 A35E_RS01575 A35E_RS01575 600772 603637 - excinuclease ABC subunit A gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01575 A35E_RS01580 A35E_00334 A35E_RS01580 605133 605828 + 7-cyano-7-deazaguanine synthase YbaX%3B catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0)%2C as one of the early reactions of quenosine biosynthesis%3B quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn%2C Asp%2C Tyr%2C and His gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01580 A35E_RS01585 A35E_00335 A35E_RS01585 606502 606954 + DNA polymerase III subunit chi binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01585 A35E_RS01590 A35E_00337 A35E_RS01590 606971 609829 + valine--tRNA ligase gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01590 A35E_RS01595 A35E_00338 smpB smpB 611127 611609 - SsrA-binding protein binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes%3B also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site%3B SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus%3B both the tmRNA and SmpB are regulated in cell cycle-dependent manner%3B functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01595 A35E_RS01600 A35E_00339 A35E_RS01600 612730 612801 - tRNA-Gln tRNA gene320 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01600 A35E_RS01605 A35E_00340 A35E_RS01605 612814 612890 - tRNA-Met tRNA gene321 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01605 A35E_RS01610 A35E_00341 A35E_RS01610 613038 613109 - tRNA-Gln tRNA gene322 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01610 A35E_RS01615 A35E_00342 A35E_RS01615 613132 613213 - tRNA-Leu tRNA gene323 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01615 A35E_RS01620 A35E_00343 cysS cysS 614952 616340 + cysteinyl-tRNA synthetase catalyzes a two-step reaction%3B charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01620 A35E_RS01625 A35E_00344 A35E_RS01625 616584 617453 - methenyltetrahydrofolate cyclohydrolase gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01625 A35E_RS01630 A35E_00345 A35E_RS01630 617611 617687 + tRNA-Arg tRNA gene326 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01630 A35E_RS01635 A35E_00346 lnt lnt 618011 619573 - apolipoprotein N-acyltransferase Transfers the fatty acyl group on membrane lipoproteins gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01635 A35E_RS01640 A35E_00347 rpmE rpmE 620260 620472 - 50S ribosomal protein L31 RpmE%3B there appears to be two types of ribosomal proteins L31 in bacterial genomes%3B some contain a CxxC motif while others do not%3B Bacillus subtilis has both types%3B the proteins in this cluster have the CXXC motif%3B RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth%3B expression of ytiA is controlled by a zinc-specific transcriptional repressor%3B RpmE contains one zinc ion and a CxxC motif is responsible for this binding%3B forms an RNP particle along with proteins L5%2C L18%2C and L25 and 5S rRNA%3B found crosslinked to L2 and L25 and EF-G%3B may be near the peptidyltransferase site of the 50S ribosome gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01640 A35E_RS01645 A35E_00348 A35E_RS01645 620653 622854 + primosome assembly protein PriA binding of PriA to forked DNA starts the assembly of the primosome%2C also possesses 3'-5' helicase activity gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01645 A35E_RS01650 A35E_00349 A35E_RS01650 623244 624134 - nicotinate-nucleotide pyrophosphorylase catalyzes the formation of pyridine-2%2C3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01650 A35E_RS01655 A35E_00351 A35E_RS01655 627551 628639 + 3-phosphoserine/phosphohydroxythreonine aminotransferase catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate%3B catalyzes 4 phosphohydroxy L-threonine from 2-oxo 3 hydroxy 4- phosphobutanoate%3B required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01655 A35E_RS01660 A35E_00352 A35E_RS01660 629778 631193 + 6-phosphogluconate dehydrogenase catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01660 A35E_RS01665 A35E_00353 A35E_RS01665 631925 632386 + 16S rRNA maturation RNase YbeY gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01665 A35E_RS01670 A35E_00354 ygfZ ygfZ 633222 634205 + global regulator physiological role is not clear%3B not essential for growth but mutants grow poorly%3B mutations suppress hda null mutations%3B may be involved in regulation of ATP-DnaA levels%3B may also be involved in regulation of tRNA modifications%3B can bind folic acid and tetrahydrofolate%3B forms a three domain ring-like structure with a central channel%3B structurally similar to DMGO protein from A. globiformis%3B shows sequence similarity to yeast CAF17 transcriptional regulato%3B Hda supressor gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01670 A35E_RS01675 A35E_00355 A35E_RS01675 634531 635325 - methionine aminopeptidase catalyzes the removal of N-terminal amino acids from peptides and arylamides%3B generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn%2C Fe%2C or Mn gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01675 A35E_RS01680 A35E_00356 A35E_RS01680 636634 636891 + hypothetical protein gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01680 A35E_RS01685 A35E_00357 A35E_RS01685 636947 638197 + UDP-N-acetylglucosamine 1-carboxyvinyltransferase gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01685 A35E_RS01690 A35E_00358 A35E_RS01690 642561 642637 + tRNA-Val tRNA gene338 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01690 A35E_RS01695 A35E_00359 A35E_RS01695 645548 646510 + 6-phosphofructokinase catalyzes the formation of D-fructose 1%2C6-bisphosphate from D-fructose 6-phosphate in glycolysis gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01695 A35E_RS01700 A35E_00360 A35E_RS01700 647560 647799 - septal ring assembly protein ZapB interacts with FisZ and is necessary for Z-ring formation gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01700 A35E_RS01705 A35E_RS01705 A35E_RS01705 649503 652007 - DNA mismatch repair protein MutS This protein performs the mismatch recognition step during the DNA repair process gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01705 A35E_RS01710 A35E_00364 A35E_RS01710 653965 655215 - serine hydroxymethyltransferase gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01710 A35E_RS01715 A35E_00366 ispF ispF 657057 657560 - 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01715 A35E_RS01720 A35E_00367 A35E_RS01720 657572 658285 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01720 A35E_RS01725 A35E_00368 ihfA ihfA 660172 660468 - integration host factor subunit alpha This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01725 A35E_RS01730 A35E_00369 A35E_RS01730 660473 662872 - phenylalanine--tRNA ligase subunit beta gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01730 A35E_RS01735 A35E_00370 A35E_RS01735 662888 663871 - phenylalanyl-tRNA synthetase subunit alpha gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01735 A35E_RS01740 A35E_00371 rplT rplT 665185 665541 - 50S ribosomal protein L20 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01740 A35E_RS01745 A35E_00372 A35E_RS01745 665586 665783 - 50S ribosomal protein L35 gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01745 A35E_RS01750 A35E_RS01750 A35E_RS01750 665860 666354 - translation initiation factor IF-3 gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01750 A35E_RS01755 A35E_00374 thrS thrS 666412 668340 - threonyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01755 A35E_RS01760 A35E_00375 aroK aroK 669448 669969 - shikimate kinase type I enzyme similar to type II but differentially regulated%3B major shikimate kinase in fully repressed cells%3B catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01760 A35E_RS01765 A35E_00376 A35E_RS01765 672343 674190 - RNA polymerase sigma factor RpoD sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released%3B this is the primary sigma factor of bacteria gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01765 A35E_RS01770 A35E_00377 dnaG dnaG 674346 676097 - DNA primase synthesizes RNA primers at the replication forks gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01770 A35E_RS01775 A35E_00378 rpsU rpsU 676224 676439 - 30S ribosomal protein S21 a small basic protein that is one of the last in the subunit assembly%3B omission does not prevent assembly but the subunit is inactive%3B binds central domain of 16S rRNA gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01775 A35E_RS01780 A35E_00379 A35E_RS01780 677728 678480 - Nif3-like dinuclear metal center hexameric protein gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01780 A35E_RS01785 A35E_00380 A35E_RS01785 679332 679841 - ferritin cytoplasmic iron storage protein gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01785 A35E_RS01790 A35E_00381 ribD ribD 680375 681502 + diaminohydroxyphosphoribosylaminopyrimidine deaminase riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway%3B catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2%2C5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01790 A35E_RS01795 A35E_00382 ribH ribH 681584 682054 + 6%2C7-dimethyl-8-ribityllumazine synthase RibE%3B 6%2C7-diimethyl-8-ribityllumazine synthase%3B DMRL synthase%3B lumazine synthase%3B beta subunit of riboflavin synthase%3B condenses 5-amino-6-(1'-D)-ribityl-amino-2%2C4(1H%2C3H)-pyrimidinedione with L-3%2C4-dihydrohy-2-butanone-4-phosphate to generate 6%2C6-dimethyl-8-lumazine (DMRL)%3B riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12)%3B involved in the last steps of riboflavin biosynthesis%3B forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli%3B in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01795 A35E_RS01800 A35E_00383 nusB nusB 682068 682505 + transcription antitermination protein NusB Regulates rRNA biosynthesis by transcriptional antitermination gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01800 A35E_RS01805 A35E_00384 A35E_RS01805 685027 688251 + ribonuclease E gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01805 A35E_RS01810 A35E_00385 A35E_RS01810 690008 690193 - carbon storage regulator affects carbohydrate metabolism%3B has regulatory role in many processes gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01810 A35E_RS01815 A35E_00386 A35E_RS01815 690461 693091 - alanyl-tRNA synthetase gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01815 A35E_RS01820 A35E_00387 secA secA 695528 698224 - preprotein translocase subunit SecA functions in protein export%3B can interact with acidic membrane phospholipids and the SecYEG protein complex%3B binds to preproteins%3B binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein%3B ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane%3B additional proteins SecD/F/YajC aid SecA recycling%3B exists in an equilibrium between monomers and dimers%3B may possibly form higher order oligomers%3B proteins in this cluster correspond SecA1%3B SecA2 is not essential and seems to play a role in secretion of a subset of proteins gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01820 A35E_RS01825 A35E_00388 A35E_RS01825 698809 699300 + hypothetical protein gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01825 A35E_RS01830 A35E_00389 lpxC lpxC 699405 700322 - UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase zinc-dependent%3B catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis gene gene368 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01830 A35E_RS01835 A35E_00390 A35E_RS01835 700429 701589 - peptidase M23 GTPase%3B similar structure to tubulin%3B forms ring-shaped polymers at the site of cell division%3B other proteins such as FtsA%2C ZipA%2C and ZapA%2C interact with and regulate FtsZ function gene gene369 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01835 A35E_RS01840 A35E_00391 ftsA ftsA 701666 702922 - cell division protein FtsA ATP-binding involved in recruitment of FtsK to Z ring%3B essential cell division protein%3B colocalizes with FtsZ through direct interaction to the septal ring structure%3B structurally similar to eukaryotic actin%3B binds directly to the cell membrane gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01840 A35E_RS01850 A35E_00394 A35E_RS01850 703787 705283 - UDP-N-acetylmuramate--alanine ligase gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01850 A35E_RS01855 A35E_00395 murG murG 705361 706440 - UDP-diphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase N-acetylglucosaminyl transferase%3B UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase%3B involved in cell wall formation%3B inner membrane-associated%3B last step of peptidoglycan synthesis gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01855 A35E_RS01860 A35E_RS01860 A35E_RS01860 706437 707642 - cell division protein FtsW integral membrane protein involved in stabilizing FstZ ring during cell division gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01860 A35E_RS01865 A35E_00397 murD murD 707639 708955 - UDP-N-acetylmuramoylalanine--D-glutamate ligase UDP-N-acetylmuramoylalanine--D-glutamate ligase%3B involved in peptidoglycan biosynthesis%3B cytoplasmic%3B catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01865 A35E_RS01870 A35E_00398 mraY mraY 708958 710040 - phospho-N-acetylmuramoyl-pentapeptide transferase First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01870 A35E_RS01875 A35E_00399 murF murF 710034 711389 - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01875 A35E_RS01880 A35E_00400 murE murE 711386 712876 - UDP-N-acetylmuramoylalanyl-D-glutamate--2%2C 6-diaminopimelate ligase involved in cell wall formation%3B peptidoglycan synthesis%3B cytoplasmic enzyme%3B catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01880 A35E_RS01885 A35E_RS01885 A35E_RS01885 712869 714585 - cell division protein FtsI penicillin-binding protein 3%3B transpeptidase involved in septal peptidoglycan synthesis gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01885 A35E_RS01890 A35E_00404 A35E_RS01890 714989 715936 - 16S rRNA (cytosine(1402)-N(4))-methyltransferase gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01890 A35E_RS01895 A35E_00405 A35E_RS01895 718228 719526 + 16S rRNA methyltransferase catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA%3B SAM-dependent methyltransferase gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01895 A35E_RS01900 A35E_00406 A35E_RS01900 720603 721061 - xanthine phosphoribosyltransferase catalyzes the conversion of guanine%2C xanthine and%2C to a lesser extent%2C hypoxanthine to GMP%2C XMP and IMP%2C respectively gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01900 A35E_RS01905 A35E_00407 A35E_RS01905 721817 721906 - tRNA-Ser tRNA gene383 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01905 A35E_RS01910 A35E_00408 A35E_RS01910 723405 724004 - co-chaperone GrpE with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%3B may act as a thermosensor gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01910 A35E_RS01915 A35E_00409 A35E_RS01915 724431 724634 + hypothetical protein gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01915 A35E_RS01920 A35E_00410 A35E_RS01920 726156 726506 + small protein A (tmRNA-binding) gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01920 A35E_RS01925 A35E_00411 A35E_RS01925 727080 727340 - oligoketide cyclase/lipid transporter gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01925 A35E_RS01930 A35E_00412 A35E_RS01930 728576 728794 - hypothetical protein required for phi X174 lysis gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01930 A35E_RS01935 A35E_00413 queF queF 729530 730369 - 7-cyano-7-deazaguanine reductase catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01935 A35E_RS01940 A35E_00414 pyrG pyrG 732255 733919 + CTP synthase CTP synthase%3B cytidine triphosphate synthetase%3B catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B in Escherichia coli this enzyme forms a homotetramer gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01940 A35E_RS01945 A35E_00415 eno eno 733970 735271 + enolase catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01945 A35E_RS01950 A35E_00416 A35E_RS01950 735320 735991 + 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01950 A35E_RS01955 A35E_00417 A35E_RS01955 736144 736506 - 6-carboxy-5%2C6%2C7%2C8-tetrahydropterin synthase gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01955 A35E_RS01960 A35E_00418 A35E_RS01960 737610 738365 - DNA polymerase III subunit epsilon 3'-5' exonuclease of DNA polymerase III gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01960 A35E_RS01965 A35E_00419 A35E_RS01965 740232 742001 + multidrug ABC transporter ATP-binding protein gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01965 A35E_RS01970 A35E_00420 A35E_RS01970 742001 743767 + multidrug ABC transporter ATP-binding protein gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01970 A35E_RS01975 A35E_00421 A35E_RS01975 745056 745730 + ribose 5-phosphate isomerase catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01975 A35E_RS01980 A35E_00422 A35E_RS01980 746723 747856 + erythronate-4-phosphate dehydrogenase catalyzes the formation of 3-hydroxy-2-oxo-4-phosphonooxybutanoate from erythronate-4-phosphate gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01980 A35E_RS01985 A35E_00423 A35E_RS01985 748680 749297 + riboflavin synthase subunit alpha catalyzes the formation of riboflavin from 6%2C7-dimethyl-8-(1-D-ribityl)lumazine gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01985 A35E_RS01990 A35E_00424 emrD emrD 750901 752067 + multidrug resistance protein D multidrug efflux protein involved in adaptation to low energy shock gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01990 A35E_RS01995 A35E_00425 metG metG 756585 758225 - methionine--tRNA ligase methionine--tRNA ligase%3B MetRS%3B adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate%3B some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not%3B four subfamilies exist based on sequence motifs and zinc content gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS01995 A35E_RS02000 A35E_00426 A35E_RS02000 759274 760392 + porin gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02000 A35E_RS02005 A35E_00427 A35E_RS02005 761092 761553 + ribonuclease H gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02005 A35E_RS02010 A35E_00428 truA truA 762371 763156 - tRNA pseudouridine synthase A mediates pseudouridylation (positions 38%2C 39%2C 40) at the tRNA anticodon region which contributes to the structural stability gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02010 A35E_RS02015 A35E_00429 recC recC 764255 767641 - exonuclease V subunit gamma catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides%3B component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02015 A35E_RS02020 A35E_RS02020 A35E_RS02020 769799 770887 + DNA polymerase III subunit gamma/tau gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02020 A35E_RS02025 A35E_00431 A35E_RS02025 772605 773243 - hypothetical protein gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02025 A35E_RS02030 A35E_00432 A35E_RS02030 773746 775086 + UDP-glucose 6-dehydrogenase gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02030 A35E_RS02035 A35E_00433 A35E_RS02035 775099 776106 + hypothetical protein gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02035 A35E_RS02040 A35E_00434 A35E_RS02040 776697 777503 - exonuclease III gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02040 A35E_RS02045 A35E_00435 A35E_RS02045 780047 781717 + glutamine--tRNA ligase gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02045 A35E_RS02050 A35E_00436 A35E_RS02050 783272 784474 + acetate kinase AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation%3B utilizes magnesium and ATP%3B also involved in conversion of acetate to aceyl-CoA%3B also known to act on propionate gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02050 A35E_RS02055 A35E_00437 A35E_RS02055 784553 786697 + phosphate acetyltransferase catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate%3B when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02055 A35E_RS02060 A35E_00438 A35E_RS02060 787694 788227 + inorganic pyrophosphatase catalyzes the hydrolysis of pyrophosphate to phosphate gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02060 A35E_RS02065 A35E_00439 minE minE 789292 789597 - cell division topological specificity factor MinE works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02065 A35E_RS02070 A35E_00440 A35E_RS02070 789601 790413 - cell division inhibitor MinD ATPase%3B with MinC inhibits cell division by blocking formation of the polar Z ring septums gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02070 A35E_RS02075 A35E_00441 minC minC 790435 791115 - septum formation inhibitor blocks the formation of polar Z-ring septums gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02075 A35E_RS02080 A35E_00442 A35E_RS02080 794329 794715 + sulfur transfer complex subunit TusD in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02080 A35E_RS02085 A35E_00443 A35E_RS02085 794723 795082 + sulfur relay protein TusC gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02085 A35E_RS02090 A35E_00444 A35E_RS02090 795097 795384 + sulfur transfer complex subunit TusB in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02090 A35E_RS02095 A35E_00445 A35E_RS02095 795518 795892 + 30S ribosomal protein S12 gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02095 A35E_RS02100 A35E_00446 A35E_RS02100 795984 796454 + 30S ribosomal protein S7 gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02100 A35E_RS02105 A35E_00447 fusA fusA 796555 798660 + elongation factor G EF-G%3B promotes GTP-dependent translocation of the ribosome during translation%3B many organisms have multiple copies of this gene gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02105 A35E_RS02110 A35E_00448 tuf tuf 798728 799912 + elongation factor Tu EF-Tu%3B promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B when the tRNA anticodon matches the mRNA codon%2C GTP hydrolysis results%3B the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts%3B many prokaryotes have two copies of the gene encoding EF-Tu gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02110 A35E_RS02115 A35E_00449 A35E_RS02115 800729 801223 + RNA pyrophosphohydrolase hydrolyzes diadenosine polyphosphate gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02115 A35E_RS02120 A35E_00450 A35E_RS02120 802024 803658 - phosphoglucomutase catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02120 A35E_RS02125 A35E_00451 A35E_RS02125 804603 805322 - UDP-2%2C3-diacylglucosamine hydrolase catalyzes the formation of 2%2C3%3Ddiacylglucosamine 1-phosphate from UDP-2%2C3%3Ddiacylglucosamine gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02125 A35E_RS02130 A35E_00452 A35E_RS02130 806505 807872 - adenylosuccinate lyase Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02130 A35E_RS02135 A35E_00453 mnmA mnmA 809414 810520 - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02135 A35E_RS02140 A35E_00454 A35E_RS02140 812026 812454 + 50S ribosomal protein L13 gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02140 A35E_RS02145 A35E_00455 A35E_RS02145 812470 812862 + 30S ribosomal protein S9 gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02145 A35E_RS02150 A35E_00456 A35E_RS02150 814180 814295 - 5S ribosomal RNA rRNA gene432 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02150 A35E_RS02155 A35E_00457 fmt fmt 815201 816151 - methionyl-tRNA formyltransferase modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation%3B inactivation of this gene in Escherichia coli severely impairs growth gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02155 A35E_RS02160 A35E_00458 A35E_RS02160 816160 816687 - peptide deformylase gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02160 A35E_RS02165 A35E_00459 A35E_RS02165 817491 817566 - tRNA-Thr tRNA gene435 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02165 A35E_RS02170 A35E_00460 A35E_RS02170 818043 818996 + thioredoxin reductase catalyzes the transfer of electrons from NADPH to thioredoxin%3B FAD/NAD(P) binding gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02170 A35E_RS02175 A35E_00461 A35E_RS02175 819748 820320 - tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein involved in the biosynthesis of the threonylcarbamoyladenosine (t6A) residue at position 37 of ANN-decoding tRNAs gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02175 A35E_RS02180 A35E_00462 A35E_RS02180 822502 823686 - outer membrane biogenesis protein BamB gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02180 A35E_RS02185 A35E_00463 A35E_RS02185 823696 824319 - hypothetical protein gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02185 A35E_RS02190 A35E_00464 hisS hisS 824340 825614 - histidyl-tRNA synthetase catalyzes a two-step reaction%2C first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP%2C followed by transfer of the aminoacyl-adenylate to its tRNA%3B class II aminoacyl-tRNA synthetase%3B forms homodimers%3B some organisms have a paralogous gene%2C hisZ%2C that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02190 A35E_RS02195 A35E_00465 A35E_RS02195 825631 826755 - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02195 A35E_RS02200 A35E_00466 A35E_RS02200 827143 827643 - XRE family transcriptional regulator gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02200 A35E_RS02205 A35E_00467 A35E_RS02205 828443 829543 - 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN 23S rRNA m2A2503 methyltransferase%3B methylates the C2 position of the A2530 nucleotide in 23S rRNA%3B may be involved in antibiotic resistance gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02205 A35E_RS02210 A35E_00468 A35E_RS02210 830986 831249 + hypothetical protein gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02210 A35E_RS02215 A35E_00469 A35E_RS02215 831264 831920 + lipoate-protein ligase B lipoyl/octanoyltransferase%3B catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02215 A35E_RS02220 A35E_00470 A35E_RS02220 832093 833058 + lipoyl synthase catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02220 A35E_RS02225 A35E_00471 gmhA gmhA 834335 834913 - phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02225 A35E_RS02230 A35E_00472 A35E_RS02230 836079 836288 - cold-shock protein CspC gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02230 A35E_RS02235 A35E_00473 A35E_RS02235 837673 838239 + elongation factor P gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02235 A35E_RS02240 A35E_00474 A35E_RS02240 838633 838715 - tRNA-Leu tRNA gene450 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02240 A35E_RS02245 A35E_00475 A35E_RS02245 838735 838808 - tRNA-Cys tRNA gene451 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02245 A35E_RS02250 A35E_00476 A35E_RS02250 840282 841364 + D-alanine--D-alanine ligase gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02250 A35E_RS02255 A35E_00477 A35E_RS02255 841957 842682 - 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02255 A35E_RS02260 A35E_00478 A35E_RS02260 844266 845531 - tellurium resistance protein TerC gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02260 A35E_RS02265 A35E_00479 ispH ispH 847801 848751 - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)%3B functions in the nonmevalonate isoprenoid biosynthesis pathway gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02265 A35E_RS02270 A35E_00480 lspA lspA 849880 850380 - lipoprotein signal peptidase lipoprotein signal peptidase%3B integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02270 A35E_RS02275 A35E_00481 ileS ileS 850380 853196 - isoleucyl-tRNA synthetase IleRS%3B catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile)%3B since isoleucine and other amino acids such as valine are similar%2C there are additional editing function in this enzyme%3B one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile)%3B there are two active sites%2C one for aminoacylation and one for editing%3B class-I aminoacyl-tRNA synthetase family type 1 subfamily%3B some organisms carry two different copies of this enzyme gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02275 A35E_RS02280 A35E_00482 A35E_RS02280 853216 854166 - bifunctional riboflavin kinase/FMN adenylyltransferase gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02280 A35E_RS02285 A35E_00483 A35E_RS02285 855577 856974 - DNA helicase unwinds double stranded DNA gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02285 A35E_RS02290 A35E_00484 A35E_RS02290 857135 858115 + quinone oxidoreductase gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02290 A35E_RS02295 A35E_00485 folE folE 859481 860146 + GTP cyclohydrolase I involved in the first step of tetrahydrofolate biosynthesis%3B catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1%2C2%2C3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water%3B forms a homopolymer gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02295 A35E_RS02300 A35E_00486 A35E_RS02300 860442 861680 - tRNA nucleotidyl transferase gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02300 A35E_RS02305 A35E_00487 A35E_RS02305 863133 863483 + purine nucleoside phosphoramidase gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02305 A35E_RS02310 A35E_00488 A35E_RS02310 863744 864127 - Holliday junction DNA helicase similar to RuvC resolvase with substantial differences%3B NMR structural information suggests this protein is monomeric%3B unknown cellular function gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02310 A35E_RS02320 A35E_00490 A35E_RS02320 864870 865826 - glutathione synthetase catalyzes the second step in the glutathione biosynthesis pathway%2C where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine %3D ADP + phosphate + glutathione gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02320 A35E_RS02325 A35E_00491 A35E_RS02325 867324 868358 + cell division protein ZipA gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02325 A35E_RS02330 A35E_00492 A35E_RS02330 869130 869912 + inositol monophosphatase gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02330 A35E_RS02335 A35E_00493 A35E_RS02335 870998 871708 + membrane protein gene gene469 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02335 A35E_RS02340 A35E_00494 A35E_RS02340 872136 872212 - tRNA-Pro tRNA gene470 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02340 A35E_RS02345 A35E_00495 A35E_RS02345 874738 875310 + D%2CD-heptose 1%2C7-bisphosphate phosphatase Converts the D-glycero-beta-D-manno-heptose 1%2C7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate gene gene471 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02345 A35E_RS02350 A35E_00496 A35E_RS02350 875761 876492 + 30S ribosomal protein S2 gene gene472 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02350 A35E_RS02355 A35E_00497 tsf tsf 876607 877407 + elongation factor Ts EF-Ts%3B functions during elongation stage of protein translation%3B forms a dimer%3B associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02355 A35E_RS02360 A35E_00498 A35E_RS02360 877595 878332 + uridylate kinase gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02360 A35E_RS02365 A35E_00499 frr frr 878389 878946 + ribosome recycling factor Rrf%3B Frr%3B ribosome-recycling factor%3B release factor 4%3B RF4%3B recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G%3B A GTPase-dependent process results in release of 50S from 70S%3B inhibited by release factor RF-1%3B essential for viability%3B structurally similar to tRNAs gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02365 A35E_RS02370 A35E_00500 A35E_RS02370 879097 880293 + 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzes the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02370 A35E_RS02375 A35E_00501 A35E_RS02375 881808 882584 + UDP pyrophosphate synthase catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02375 A35E_RS02380 A35E_00502 cdsA cdsA 882581 883426 + CDP-diglyceride synthase catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02380 A35E_RS02385 A35E_00503 A35E_RS02385 884379 885617 + zinc metallopeptidase RseP catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02385 A35E_RS02390 A35E_00504 A35E_RS02390 885654 888080 + outer membrane protein assembly factor YaeT part of a complex with YfgL%2C YfiO%2C and NlpB involved in outer membrane protein biosynthesis%3B involved in the assembly of outer membrane proteins gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02390 A35E_RS02395 A35E_00505 A35E_RS02395 888215 888712 + molecular chaperone gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02395 A35E_RS02400 A35E_00506 lpxD lpxD 888716 889741 + UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02400 A35E_RS02405 A35E_00507 A35E_RS02405 889820 890275 + hydroxymyristoyl-ACP dehydratase gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02405 A35E_RS02410 A35E_00508 A35E_RS02410 890280 891068 + UDP-N-acetylglucosamine acyltransferase catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02410 A35E_RS02415 A35E_00509 lpxB lpxB 891071 892246 + lipid-A-disaccharide synthase catalyzes the formation of lipid A disaccharide from UDP-2%2C3-diacylglucosamine and 2%2C3-diacylglucosamine-1-phosphate%2C lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02415 A35E_RS02420 A35E_00510 dnaE dnaE 893368 896853 + DNA polymerase III subunit alpha catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time%3B main replicative polymerase gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02420 A35E_RS02425 A35E_00511 A35E_RS02425 896866 897825 + acetyl-CoA carboxylase subunit alpha catalyzes the carboxylation of acetyl-CoA to malonyl-CoA%3B forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits%3B one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02425 A35E_RS02430 A35E_00512 dksA dksA 898877 899332 + transcriptional regulator gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02430 A35E_RS02435 A35E_00513 A35E_RS02435 900348 901130 - hypothetical protein gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02435 A35E_RS02440 A35E_00514 A35E_RS02440 905195 905680 - adenosine deaminase gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02440 A35E_RS02445 A35E_00515 A35E_RS02445 906374 908995 - DNA topoisomerase I catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining%2C maintains net negative superhelicity gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02445 A35E_RS02450 A35E_00516 A35E_RS02450 910609 911487 + prolipoprotein diacylglyceryl transferase transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02450 A35E_RS02455 A35E_00517 A35E_RS02455 912157 913110 + PTS mannose transporter subunit IIAB catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B subunit IIA transfers a phosphoryl group to subunit IIB%3B subunit IIB transfers the phosphoryl group to the substrate gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02455 A35E_RS02460 A35E_00518 A35E_RS02460 913198 913998 + PTS mannose transporter subunit IIC catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B the IIC domain forms the PTS system translocation channel and contains the specific substrate-binding site gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02460 A35E_RS02465 A35E_00519 A35E_RS02465 914008 914859 + PTS mannose transporter subunit IID hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B IID with IIC forms the translocation channel gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02465 A35E_RS02470 A35E_00520 yajC yajC 917607 917939 - preprotein translocase subunit YajC member of preprotein translocase%3B forms a heterotrimer with SecD and SecF%3B links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02470 A35E_RS02475 A35E_00521 tgt tgt 917969 919087 - queuine tRNA-ribosyltransferase Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr) gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02475 A35E_RS02480 A35E_00522 A35E_RS02480 921108 922061 - type I pantothenate kinase gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02480 A35E_RS02485 A35E_00523 pepN pepN 923384 926002 - aminopeptidase N gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02485 A35E_RS02490 A35E_00524 A35E_RS02490 928263 929525 - transporter part of the ATP-dependent transport system LolCDE%3B responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02490 A35E_RS02495 A35E_00525 lolD lolD 929527 930210 - peptide ABC transporter ATP-binding protein outer membrane specific%3B part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02495 A35E_RS02500 A35E_00526 A35E_RS02500 930203 931396 - transporter gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02500 A35E_RS02505 A35E_RS02505 A35E_RS02505 931654 935048 + transcription-repair coupling factor gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02505 A35E_RS02510 A35E_00528 lolA lolA 936059 936670 + outer membrane lipoprotein carrier protein LolA participates with LolB in the incorporation of lipoprotein into the outer membrane gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02510 A35E_RS02515 A35E_00529 A35E_RS02515 938322 939629 + seryl-tRNA synthetase gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02515 A35E_RS02520 A35E_00530 A35E_RS02520 940807 942843 + oligopeptidase A gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02520 A35E_RS02525 A35E_00531 A35E_RS02525 943978 944619 + uridine/cytidine kinase gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02525 A35E_RS02530 A35E_00532 A35E_RS02530 945222 947252 + ATP-dependent DNA helicase Rep single-stranded DNA-dependent ATPase%3B initiates unwinding at a nick in the DNA%3B involved in DNA replication gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02530 A35E_RS02535 A35E_00533 A35E_RS02535 948282 949046 - ribosomal large subunit pseudouridine synthase B gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02535 A35E_RS02540 A35E_00534 A35E_RS02540 950214 950648 + MarR family transcriptional regulator Transcription regulator that can both activate or repress expression gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02540 A35E_RS02545 A35E_00535 A35E_RS02545 952522 953193 + membrane protein gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02545 A35E_RS02550 A35E_00536 A35E_RS02550 955804 957279 + ribosome-associated GTPase EngA gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02550 A35E_RS02555 A35E_00537 A35E_RS02555 958492 959250 + oxoacyl-ACP reductase gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02555 A35E_RS02560 A35E_00538 trmB trmB 959565 960284 - tRNA (guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase%3B catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02560 A35E_RS02565 A35E_00540 A35E_RS02565 963409 963936 + single-stranded DNA-binding protein gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02565 A35E_RS02570 A35E_00541 A35E_RS02570 965716 966216 + stringent starvation protein B gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02570 A35E_RS02575 A35E_00542 A35E_RS02575 967335 968240 + UTP--glucose-1-phosphate uridylyltransferase together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase%2C an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate%3B regulates cellular levels of UDP-glucose gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02575 A35E_RS02580 A35E_00543 A35E_RS02580 971326 972762 + exonuclease I gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02580 A35E_RS02585 A35E_00544 A35E_RS02585 974703 975833 - ribonucleotide-diphosphate reductase subunit beta B2 or R2 protein%3B type 1a enzyme%3B catalyzes the rate-limiting step in dNTP synthesis%3B converts nucleotides to deoxynucleotides%3B forms a homodimer and then a multimeric complex with NrdA gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02585 A35E_RS02590 A35E_00545 A35E_RS02590 975888 978158 - ribonucleotide-diphosphate reductase subunit alpha Catalyzes the rate-limiting step in dNTP synthesis gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02590 A35E_RS02595 A35E_00546 rpsT rpsT 979521 979784 - 30S ribosomal protein S20 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02595 A35E_RS02600 A35E_RS02600 A35E_RS02600 984403 985483 + adenine glycosylase gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02600 A35E_RS02605 A35E_00550 A35E_RS02605 985492 985764 + iron transporter protects iron-sulfur proteins against oxidative damage gene gene523 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02605 A35E_RS02610 A35E_00551 mltC mltC 985822 986895 + murein transglycosylase Murein hydrolase C%3B membrane-bound%3B lytic%3B catalyzes the cleavage of the beta-1%2C4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02610 A35E_RS02615 A35E_00552 A35E_RS02615 988146 989450 - trigger factor gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02615 A35E_RS02620 A35E_00553 lpxK lpxK 990911 991924 - tetraacyldisaccharide 4'-kinase transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1%2C4'-bis-phosphate gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02620 A35E_RS02625 A35E_00554 A35E_RS02625 991924 993669 - ATP-binding protein involved in the transport of lipid A across the inner membrane gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02625 A35E_RS02630 A35E_00555 A35E_RS02630 994824 994900 - tRNA-Pro tRNA gene528 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02630 A35E_RS02635 A35E_00556 A35E_RS02635 995077 995152 - tRNA-His tRNA gene529 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02635 A35E_RS02640 A35E_00557 A35E_RS02640 995220 995293 - tRNA-Arg tRNA gene530 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02640 A35E_RS02645 A35E_00558 A35E_RS02645 996536 998107 - glutamate--cysteine ligase involved in the first step of glutathione biosynthesis gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02645 A35E_RS02650 A35E_00559 A35E_RS02650 1000254 1001624 + serine endoprotease gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02650 A35E_RS02655 A35E_RS02655 slmA slmA 1002839 1003423 - division inhibitor protein FtsZ binding protein%3B synthetically lethal with a defect in the Min system%3B this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02655 A35E_RS02660 A35E_00561 A35E_RS02660 1003547 1004005 - deoxyuridine 5'-triphosphate nucleotidohydrolase catalyzes the formation of dUMP from dUTP gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02660 A35E_RS02665 A35E_00562 A35E_RS02665 1003983 1005197 - phosphopantothenoylcysteine decarboxylase catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C which is then decarboxylated to form 4'-phosphopantotheine gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02665 A35E_RS02670 A35E_RS02670 A35E_RS02670 1008258 1008970 - uracil-DNA glycosylase Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02670 A35E_RS02675 A35E_00565 A35E_RS02675 1009896 1010576 - ribulose-phosphate 3-epimerase gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02675 A35E_RS02680 A35E_00566 A35E_RS02680 1013025 1014908 - peptidyl-prolyl isomerase gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02680 A35E_RS02685 A35E_00567 A35E_RS02685 1016794 1016870 - tRNA-Asn tRNA gene539 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02685 A35E_RS02690 A35E_00568 A35E_RS02690 1018078 1018350 - lipoprotein gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02690 A35E_RS02695 A35E_00569 gyrB gyrB 1020095 1022509 - DNA gyrase subunit B negatively supercoils closed circular double-stranded DNA gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02695 A35E_RS02700 A35E_00570 A35E_RS02700 1025014 1025529 + flavodoxin An electron-transfer protein%3B flavodoxin binds one FMN molecule%2C which serves as a redox-active prosthetic group gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02700 A35E_RS02705 A35E_00571 rpmF rpmF 1031370 1031537 + 50S ribosomal protein L32 some L32 proteins have zinc finger motifs consisting of CXXC while others do not gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02705 A35E_RS02710 A35E_00572 A35E_RS02710 1031595 1032596 + phosphate acyltransferase gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02710 A35E_RS02715 A35E_00573 A35E_RS02715 1032607 1033560 + 3-oxoacyl-ACP synthase FabH%3B beta-ketoacyl-acyl carrier protein synthase III%3B catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation%3B differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02715 A35E_RS02720 A35E_00574 A35E_RS02720 1033576 1034505 + malonyl CoA-ACP transacylase gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02720 A35E_RS02725 A35E_00575 fabG fabG 1034519 1035253 + 3-ketoacyl-ACP reductase catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02725 A35E_RS02730 A35E_00576 A35E_RS02730 1035405 1035641 + acyl carrier protein carries the fatty acid chain in fatty acid biosynthesis gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02730 A35E_RS02735 A35E_RS02735 A35E_RS02735 1037555 1039286 + hypothetical protein gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02735 A35E_RS02740 A35E_00580 A35E_RS02740 1039372 1039890 + 3-hydroxydecanoyl-ACP dehydratase catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2%2C3-decenoyl-ACP or 3%2C4-decenoyl-ACP gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02740 A35E_RS02745 A35E_00581 A35E_RS02745 1041873 1042574 + 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02745 A35E_RS02750 A35E_00582 A35E_RS02750 1043312 1044793 - glucose-6-phosphate 1-dehydrogenase catalyzes the formation of D-glucono-1%2C5-lactone 6-phosphate from D-glucose 6-phosphate gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02750 A35E_RS02755 A35E_00583 A35E_RS02755 1047592 1048137 + CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02755 A35E_RS02760 A35E_00584 A35E_RS02760 1049436 1050482 - quinolinate synthetase 3 different subfamilies%3B catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02760 A35E_RS02765 A35E_00585 greA greA 1052440 1052919 + transcription elongation factor GreA necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites%3B arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02765 A35E_RS02770 A35E_00586 rrmJ rrmJ 1053536 1054165 + 23S rRNA methyltransferase Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02770 A35E_RS02775 A35E_00587 hflB hflB 1054221 1056149 + ATP-dependent metalloprotease inner membrane metalloprotease%3B may be involved in degradation of aberrant cytoplasmic and membrane proteins gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02775 A35E_RS02780 A35E_RS02780 folP folP 1057252 1058098 + dihydropteroate synthase catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7%2C8-dihydropteridine diphosphate and 4-aminobenzoate gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02780 A35E_RS02785 A35E_00590 glmM glmM 1058095 1059456 + phosphoglucosamine mutase catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02785 A35E_RS02790 A35E_00591 A35E_RS02790 1060365 1060676 + preprotein translocase subunit SecG gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02790 A35E_RS02795 A35E_00592 A35E_RS02795 1060730 1060816 + tRNA-Leu tRNA gene561 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02795 A35E_RS02800 A35E_00593 A35E_RS02800 1060878 1060954 + tRNA-Met tRNA gene562 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02800 A35E_RS02805 A35E_00594 A35E_RS02805 1061097 1061549 + hypothetical protein required for the maturation of the 30S ribosomal subunits gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02805 A35E_RS02810 A35E_00595 nusA nusA 1061571 1063058 + transcription termination factor NusA modifies transcription through interactions with RNA polymerase affecting elongation%2C readthrough%2C termination%2C and antitermination gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02810 A35E_RS02815 A35E_00596 infB infB 1063084 1065774 + translation initiation factor IF-2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02815 A35E_RS02820 A35E_00597 A35E_RS02820 1065843 1066259 + ribosome-binding factor A gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02820 A35E_RS02825 A35E_00598 truB truB 1066259 1067194 + tRNA pseudouridine synthase B catalyzes isomerization of specific uridines in RNA to pseudouridine%3B responsible for residues in T loops of many tRNAs gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02825 A35E_RS02830 A35E_RS02830 A35E_RS02830 1067319 1067588 + 30S ribosomal protein S15 gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02830 A35E_RS02835 A35E_00600 A35E_RS02835 1067840 1069957 + polynucleotide phosphorylase/polyadenylase gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02835 A35E_RS02840 A35E_00601 A35E_RS02840 1071081 1072742 + DEAD/DEAH box helicase participates in the assembly of the large subunit of the ribosome%3B plays a key role in optimal cell growth at low temperature and is required for normal cell division gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02840 A35E_RS02845 A35E_00602 A35E_RS02845 1074006 1074782 - DNAse gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02845 A35E_RS02850 A35E_00603 A35E_RS02850 1074806 1075801 - DNA polymerase III subunit delta' catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand%3B the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02850 A35E_RS02855 A35E_00604 A35E_RS02855 1075809 1076450 - thymidylate kinase gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02855 A35E_RS02860 A35E_00605 A35E_RS02860 1079068 1081002 + exoribonuclease II Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02860 A35E_RS02865 A35E_00606 A35E_RS02865 1081551 1081772 - DNA-directed RNA polymerase subunit omega gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02865 A35E_RS02870 A35E_00607 A35E_RS02870 1081818 1082441 - guanylate kinase gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02870 A35E_RS02875 A35E_00608 prfA prfA 1085345 1086427 + peptide chain release factor 1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1%3B this protein is similar to release factor 2 gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02875 A35E_RS02880 A35E_00609 A35E_RS02880 1086424 1087266 + N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase HemK%3B PrmC%3B transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02880 A35E_RS02885 A35E_00610 queA queA 1088545 1089636 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02885 A35E_RS02890 A35E_00611 A35E_RS02890 1091217 1093028 + GTP-binding protein gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02890 A35E_RS02895 A35E_00612 A35E_RS02895 1094404 1095027 + Clp protease proteolytic subunit ClpP gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02895 A35E_RS02900 A35E_00613 clpX clpX 1095144 1096418 + ATP-dependent Clp protease ATP-binding subunit ClpX binds and unfolds substrates as part of the ClpXP protease gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02900 A35E_RS02905 A35E_00614 A35E_RS02905 1096625 1098988 + peptidase gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02905 A35E_RS02910 A35E_00615 A35E_RS02910 1099853 1101010 - cysteine desulfurase catalyzes the removal of elemental sulfur from cysteine to produce alanine%3B involved in NAD biosynthesis gene gene584 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02910 A35E_RS02915 A35E_00616 A35E_RS02915 1101110 1101559 - Fe-S cluster assembly transcriptional regulator IscR gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02915 A35E_RS02920 A35E_00617 A35E_RS02920 1102918 1102994 - tRNA-Arg tRNA gene586 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02920 A35E_RS02925 A35E_00618 A35E_RS02925 1103003 1103095 - tRNA-Ser tRNA gene587 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02925 A35E_RS02930 A35E_00619 A35E_RS02930 1104869 1104941 + tRNA-Thr tRNA gene588 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02930 A35E_RS02935 A35E_00620 A35E_RS02935 1104952 1105036 + tRNA-Tyr tRNA gene589 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02935 A35E_RS02940 A35E_00621 A35E_RS02940 1105199 1105273 + tRNA-Gly tRNA gene590 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02940 A35E_RS02945 A35E_00622 A35E_RS02945 1106971 1107315 + iron-sulfur cluster insertion protein ErpA essential respiratory protein A%3B may be involved in the transfer of iron-sulfur clusters%3B essential for growth using oxygen or alternate electron acceptors gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02945 A35E_RS02950 A35E_00623 A35E_RS02950 1109710 1110714 - glyceraldehyde-3-phosphate dehydrogenase gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02950 A35E_RS02955 A35E_00625 A35E_RS02955 1114666 1117128 + glycerol-3-phosphate acyltransferase PlsB%3B catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02955 A35E_RS02960 A35E_00626 A35E_RS02960 1119689 1120264 - fe/S biogenesis protein nfuA cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02960 A35E_RS02975 A35E_00024 A35E_RS02975 52364 52945 + 5-enolpyruvylshikimate-3-phosphate synthase gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02975 A35E_RS02980 A35E_00046 A35E_RS02980 100353 100640 - hypothetical protein gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02980 A35E_RS02985 A35E_RS02985 A35E_RS02985 396677 396880 - hypothetical protein gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02985 A35E_RS02990 A35E_00229 A35E_RS02990 441427 443697 - DNA mismatch repair enzyme (predicted ATPase) gene gene222 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02990 A35E_RS02995 A35E_RS02995 A35E_RS02995 656452 656532 + gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS02995 A35E_RS03000 A35E_00393 A35E_RS03000 703334 703750 - cell division septal protein gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS03000 A35E_RS03005 A35E_00489 A35E_RS03005 864321 864554 - putative transcriptional regulator gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS03005 A35E_RS03010 A35E_RS03010 A35E_RS03010 130403 130496 - Bacterial signal recognition particle RNA IMG reference gene:2512398126 ncRNA gene60 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS03010 A35E_RS03015 A35E_RS03015 A35E_RS03015 656304 656680 - bacterial RNase P ncRNA gene343 http://www.ncbi.nlm.nih.gov/gene/?term=A35E_RS03015