locus-tag	class	description
A35E_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A35E_RS00010	COG0592	DNA-directed DNA polymerase activity
A35E_RS00015	COG1846	Transcriptional regulator
A35E_RS00020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A35E_RS00025	COG4988	ABC transporter
A35E_RS00030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A35E_RS00035	COG0617	tRNA 3'-terminal CCA addition
A35E_RS00045	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A35E_RS00055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A35E_RS00060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A35E_RS00065	COG4942	peptidase
A35E_RS00070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A35E_RS00075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A35E_RS00080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A35E_RS00085	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A35E_RS00095	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A35E_RS00100	COG0564	pseudouridine synthase activity
A35E_RS00105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A35E_RS00115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A35E_RS00120	COG0539	negative regulation of cytoplasmic translation
A35E_RS00125	COG0776	regulation of translation
A35E_RS00130	COG0217	transcriptional regulatory protein
A35E_RS00135	COG2706	6-phosphogluconolactonase activity
A35E_RS00145	COG2823	Periplasmic or secreted lipoprotein
A35E_RS00155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A35E_RS00160	COG0598	Magnesium transport protein CorA
A35E_RS00170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A35E_RS00180	COG1561	YicC-like family, N-terminal region
A35E_RS00185	COG1770	oligopeptidase
A35E_RS00190	COG0439	Biotin carboxylase
A35E_RS00195	COG0511	ligase activity, forming carbon-carbon bonds
A35E_RS00200	COG1271	oxidase subunit
A35E_RS00205	COG1294	oxidase, subunit
A35E_RS00210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A35E_RS00220	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A35E_RS00230	COG0159	tryptophan synthase activity
A35E_RS00235	COG0133	tryptophan synthase activity
A35E_RS00240	COG0135	phosphoribosylanthranilate isomerase activity
A35E_RS00240	COG0134	indole-3-glycerol-phosphate synthase activity
A35E_RS00245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A35E_RS00255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A35E_RS00260	COG1121	(ABC) transporter
A35E_RS00265	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A35E_RS00270	COG0739	heme binding
A35E_RS00275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A35E_RS00280	COG1074	ATP-dependent DNA helicase activity
A35E_RS00285	COG0742	ribosomal rna small subunit methyltransferase
A35E_RS00290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A35E_RS00295	COG1435	thymidine kinase activity
A35E_RS00300	COG3118	belongs to the thioredoxin family
A35E_RS00305	COG0552	protein localization to endoplasmic reticulum
A35E_RS00310	COG2884	Cell division ATP-binding protein ftsE
A35E_RS00315	COG2177	Part of the ABC transporter FtsEX involved in
A35E_RS00330	COG1418	mRNA catabolic process
A35E_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A35E_RS00345	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A35E_RS00350	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A35E_RS00355	COG3263	regulation of cellular component size
A35E_RS00365	COG3104	oligopeptide transport
A35E_RS00370	COG1914	H( )-stimulated, divalent metal cation uptake system
A35E_RS00375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A35E_RS00380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A35E_RS00390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A35E_RS00400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A35E_RS00405	COG0018	arginyl-trna synthetase
A35E_RS00410	COG0237	dephospho-CoA kinase activity
A35E_RS00440	COG0561	phosphatase activity
A35E_RS00445	COG0306	phosphate transporter
A35E_RS00450	COG0728	peptidoglycan biosynthetic process
A35E_RS00455	COG0149	triose-phosphate isomerase activity
A35E_RS00460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A35E_RS00465	COG0017	Asparaginyl-tRNA synthetase
A35E_RS00475	COG0729	surface antigen
A35E_RS00480	COG2911	Protein conserved in bacteria
A35E_RS00485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A35E_RS00490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A35E_RS00500	COG0859	PFAM glycosyl transferase family 9
A35E_RS00505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A35E_RS00510	COG1792	Involved in formation and maintenance of cell shape
A35E_RS00515	COG1077	Cell shape determining protein MreB Mrl
A35E_RS00520	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A35E_RS00525	COG3785	DNA binding
A35E_RS00530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A35E_RS00535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A35E_RS00540	COG0180	Tryptophanyl-tRNA synthetase
A35E_RS00545	COG0193	aminoacyl-tRNA hydrolase activity
A35E_RS00550	COG0012	GTP binding
A35E_RS00555	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A35E_RS00560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A35E_RS00565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A35E_RS00575	COG0037	tRNA processing
A35E_RS00580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A35E_RS00590	COG0484	heat shock protein binding
A35E_RS00595	COG0443	Heat shock 70 kDa protein
A35E_RS00600	COG0359	binds to the 23S rRNA
A35E_RS00610	COG2965	DNA replication, synthesis of RNA primer
A35E_RS00615	COG0360	Binds together with S18 to 16S ribosomal RNA
A35E_RS00630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A35E_RS00635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A35E_RS00640	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A35E_RS00645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A35E_RS00655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A35E_RS00665	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A35E_RS00670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A35E_RS00675	COG3264	Mechanosensitive ion channel
A35E_RS00675	COG1511	domain protein
A35E_RS00680	COG0688	phosphatidylethanolamine metabolic process
A35E_RS00685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A35E_RS00690	COG0813	purine-nucleoside phosphorylase activity
A35E_RS00695	COG2885	chlorophyll binding
A35E_RS00700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A35E_RS00705	COG0571	ribonuclease III activity
A35E_RS00710	COG0681	Belongs to the peptidase S26 family
A35E_RS00715	COG0481	GTPase activity
A35E_RS00720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A35E_RS00730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A35E_RS00740	COG0006	proline dipeptidase activity
A35E_RS00745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A35E_RS00750	COG0752	glycyl-tRNA synthetase alpha subunit
A35E_RS00755	COG0751	glycine-tRNA ligase activity
A35E_RS00760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A35E_RS00765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A35E_RS00775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A35E_RS00775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A35E_RS00780	COG0445	tRNA wobble uridine modification
A35E_RS00785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A35E_RS00790	COG0762	integral membrane protein
A35E_RS00795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A35E_RS00800	COG2920	part of a sulfur-relay system
A35E_RS00805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A35E_RS00810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A35E_RS00815	COG0285	dihydrofolate synthase activity
A35E_RS00820	COG0450	alkyl hydroperoxide reductase
A35E_RS00825	COG0459	protein refolding
A35E_RS00835	COG1560	Kdo2-lipid A biosynthetic process
A35E_RS00840	COG1286	toxin biosynthetic process
A35E_RS00845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A35E_RS00845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A35E_RS00850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A35E_RS00855	COG0166	Belongs to the GPI family
A35E_RS00860	COG0326	Molecular chaperone. Has ATPase activity
A35E_RS00865	COG0563	adenylate kinase activity
A35E_RS00870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A35E_RS00870	COG0519	Catalyzes the synthesis of GMP from XMP
A35E_RS00875	COG0564	pseudouridine synthase activity
A35E_RS00880	COG0442	prolyl-tRNA aminoacylation
A35E_RS00885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A35E_RS00900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A35E_RS00905	COG0259	pyridoxamine-phosphate oxidase activity
A35E_RS00910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A35E_RS00915	COG0726	polysaccharide deacetylase
A35E_RS00920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A35E_RS00920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A35E_RS00925	COG0463	Glycosyl transferase, family 2
A35E_RS00935	COG1519	Transferase
A35E_RS00940	COG0438	transferase activity, transferring glycosyl groups
A35E_RS00945	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A35E_RS00950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A35E_RS00955	COG3117	lipopolysaccharide transmembrane transporter activity
A35E_RS00960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A35E_RS00965	COG1137	ATPase activity
A35E_RS00970	COG0736	holo-[acyl-carrier-protein] synthase activity
A35E_RS00975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A35E_RS00985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A35E_RS00990	COG2974	May be involved in recombination
A35E_RS01000	COG2926	Belongs to the UPF0265 family
A35E_RS01005	COG2166	iron-sulfur cluster assembly
A35E_RS01010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A35E_RS01015	COG0719	Fe-S assembly protein
A35E_RS01020	COG0396	ATPase activity
A35E_RS01025	COG0719	Fe-S assembly protein
A35E_RS01030	COG0316	Belongs to the HesB IscA family
A35E_RS01035	COG0795	lipopolysaccharide-transporting ATPase activity
A35E_RS01040	COG0795	lipopolysaccharide-transporting ATPase activity
A35E_RS01050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A35E_RS01060	COG1561	YicC-like family, N-terminal region
A35E_RS01065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A35E_RS01070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A35E_RS01075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A35E_RS01080	COG0557	exoribonuclease II activity
A35E_RS01085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A35E_RS01090	COG0330	HflC and HflK could
A35E_RS01095	COG0330	HflC and HflK could
A35E_RS01100	COG1923	regulation of RNA biosynthetic process
A35E_RS01105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A35E_RS01120	COG0802	atpase or kinase
A35E_RS01140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A35E_RS01145	COG0228	four-way junction DNA binding
A35E_RS01150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A35E_RS01155	COG0336	Belongs to the RNA methyltransferase TrmD family
A35E_RS01160	COG0335	large ribosomal subunit rRNA binding
A35E_RS01165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A35E_RS01170	COG1322	Protein conserved in bacteria
A35E_RS01175	COG3714	YhhN family
A35E_RS01180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A35E_RS01185	COG0508	dehydrogenase complex catalyzes the overall conversion of
A35E_RS01190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A35E_RS01200	COG0671	phosphoesterase, PA-phosphatase related
A35E_RS01205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A35E_RS01215	COG0425	Belongs to the sulfur carrier protein TusA family
A35E_RS01220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A35E_RS01230	COG0469	pyruvate kinase activity
A35E_RS01235	COG0488	(ABC) transporter
A35E_RS01240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A35E_RS01260	COG1252	NADH dehydrogenase
A35E_RS01275	COG0126	phosphoglycerate kinase activity
A35E_RS01285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A35E_RS01290	COG0495	leucyl-tRNA aminoacylation
A35E_RS01295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A35E_RS01300	COG1466	dna polymerase III delta subunit
A35E_RS01305	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A35E_RS01310	COG0768	penicillin binding
A35E_RS01315	COG0772	Belongs to the SEDS family
A35E_RS01325	COG0203	ribosomal protein L17
A35E_RS01335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A35E_RS01340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A35E_RS01345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A35E_RS01350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A35E_RS01355	COG0201	protein transport
A35E_RS01360	COG0200	Binds to the 23S rRNA
A35E_RS01365	COG1841	ribosomal large subunit assembly
A35E_RS01370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A35E_RS01375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A35E_RS01380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A35E_RS01385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A35E_RS01390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A35E_RS01395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A35E_RS01400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A35E_RS01410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A35E_RS01415	COG0255	Belongs to the universal ribosomal protein uL29 family
A35E_RS01420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A35E_RS01425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A35E_RS01430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A35E_RS01435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A35E_RS01440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A35E_RS01445	COG0089	rRNA binding
A35E_RS01450	COG0088	Forms part of the polypeptide exit tunnel
A35E_RS01455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A35E_RS01465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A35E_RS01470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A35E_RS01475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A35E_RS01480	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A35E_RS01485	COG0594	ribonuclease P activity
A35E_RS01490	COG0706	membrane insertase activity
A35E_RS01495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A35E_RS01500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A35E_RS01505	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A35E_RS01510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A35E_RS01515	COG0588	phosphoglycerate mutase activity
A35E_RS01520	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A35E_RS01525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A35E_RS01530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A35E_RS01535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A35E_RS01540	COG0085	RNA polymerase activity
A35E_RS01545	COG0222	ribosome binding
A35E_RS01550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A35E_RS01560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A35E_RS01565	COG0250	Participates in transcription elongation, termination and antitermination
A35E_RS01570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A35E_RS01580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A35E_RS01585	COG2927	DNA polymerase III (CHI subunit)
A35E_RS01595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A35E_RS01620	COG0215	cysteine-tRNA ligase activity
A35E_RS01625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A35E_RS01635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A35E_RS01645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A35E_RS01655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A35E_RS01660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A35E_RS01665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A35E_RS01670	COG0354	folic acid binding
A35E_RS01675	COG0024	Methionine aminopeptidase
A35E_RS01680	COG5007	Belongs to the BolA IbaG family
A35E_RS01685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A35E_RS01695	COG0205	6-phosphofructokinase activity
A35E_RS01700	COG3074	FtsZ-dependent cytokinesis
A35E_RS01710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A35E_RS01715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A35E_RS01720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A35E_RS01730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A35E_RS01730	COG0072	phenylalanine-tRNA ligase activity
A35E_RS01735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A35E_RS01740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A35E_RS01745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A35E_RS01750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A35E_RS01755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A35E_RS01765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A35E_RS01770	COG0358	DNA primase activity
A35E_RS01780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A35E_RS01785	COG1528	Iron-storage protein
A35E_RS01790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A35E_RS01790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A35E_RS01795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A35E_RS01800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A35E_RS01805	COG1530	ribonuclease E activity
A35E_RS01810	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A35E_RS01815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A35E_RS01820	COG0653	protein targeting
A35E_RS01830	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A35E_RS01840	COG0849	cell division
A35E_RS01850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A35E_RS01855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A35E_RS01865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A35E_RS01870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A35E_RS01875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A35E_RS01880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A35E_RS01890	COG0275	rRNA processing
A35E_RS01895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A35E_RS01895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A35E_RS01900	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A35E_RS01910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A35E_RS01930	COG2900	Belongs to the SlyX family
A35E_RS01940	COG0504	CTP synthase activity
A35E_RS01945	COG0148	phosphopyruvate hydratase activity
A35E_RS01950	COG0602	queuosine metabolic process
A35E_RS01955	COG0720	synthase
A35E_RS01960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A35E_RS01965	COG1132	(ABC) transporter
A35E_RS01970	COG1132	(ABC) transporter
A35E_RS01975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A35E_RS01980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A35E_RS01985	COG0307	riboflavin synthase, alpha
A35E_RS01990	COG2814	Major facilitator Superfamily
A35E_RS01995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A35E_RS01995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A35E_RS02005	COG0328	RNA-DNA hybrid ribonuclease activity
A35E_RS02010	COG0101	tRNA pseudouridine synthase activity
A35E_RS02015	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A35E_RS02025	COG0560	Phosphoserine phosphatase
A35E_RS02040	COG0708	Exodeoxyribonuclease III
A35E_RS02045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A35E_RS02050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A35E_RS02055	COG0280	phosphate acetyltransferase
A35E_RS02055	COG0857	belongs to the CobB CobQ family
A35E_RS02060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A35E_RS02065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A35E_RS02070	COG2894	cell division
A35E_RS02075	COG0850	regulation of cytokinetic process
A35E_RS02080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A35E_RS02085	COG2923	Belongs to the DsrF TusC family
A35E_RS02090	COG2168	tRNA wobble position uridine thiolation
A35E_RS02095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A35E_RS02100	COG0049	tRNA binding
A35E_RS02105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A35E_RS02110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A35E_RS02115	COG1051	belongs to the nudix hydrolase family
A35E_RS02120	COG0033	Phosphoglucomutase
A35E_RS02125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A35E_RS02130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A35E_RS02135	COG0482	sulfurtransferase activity
A35E_RS02145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A35E_RS02155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A35E_RS02160	COG0242	peptide deformylase activity
A35E_RS02170	COG0492	ferredoxin-NADP+ reductase activity
A35E_RS02175	COG0009	L-threonylcarbamoyladenylate synthase
A35E_RS02180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A35E_RS02185	COG2976	Protein conserved in bacteria
A35E_RS02190	COG0124	histidyl-tRNA synthetase
A35E_RS02195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A35E_RS02205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A35E_RS02210	COG2921	Belongs to the UPF0250 family
A35E_RS02215	COG0321	lipoyl(octanoyl) transferase activity
A35E_RS02220	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A35E_RS02225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A35E_RS02230	COG1278	Cold shock
A35E_RS02235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A35E_RS02250	COG1181	Belongs to the D-alanine--D-alanine ligase family
A35E_RS02255	COG0204	Acyl-transferase
A35E_RS02260	COG1253	flavin adenine dinucleotide binding
A35E_RS02265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A35E_RS02270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A35E_RS02275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A35E_RS02280	COG0196	riboflavin kinase activity
A35E_RS02285	COG0305	Participates in initiation and elongation during chromosome replication
A35E_RS02295	COG0302	gtp cyclohydrolase
A35E_RS02300	COG0617	tRNA 3'-terminal CCA addition
A35E_RS02305	COG0537	adenosine 5'-monophosphoramidase activity
A35E_RS02310	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A35E_RS02320	COG0189	ligase activity
A35E_RS02325	COG3115	cell septum assembly
A35E_RS02330	COG0483	inositol monophosphate 1-phosphatase activity
A35E_RS02335	COG0670	Belongs to the BI1 family
A35E_RS02350	COG0052	Belongs to the universal ribosomal protein uS2 family
A35E_RS02355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A35E_RS02360	COG0528	UMP kinase activity
A35E_RS02365	COG0233	cytoplasmic translational termination
A35E_RS02370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A35E_RS02375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A35E_RS02380	COG0575	Belongs to the CDS family
A35E_RS02385	COG0750	zinc metalloprotease
A35E_RS02390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A35E_RS02395	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A35E_RS02400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A35E_RS02405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A35E_RS02410	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A35E_RS02415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A35E_RS02420	COG0587	DNA-directed DNA polymerase activity
A35E_RS02425	COG0825	malonyl-CoA metabolic process
A35E_RS02430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A35E_RS02435	COG1388	LysM domain
A35E_RS02435	COG4942	peptidase
A35E_RS02440	COG0590	tRNA wobble adenosine to inosine editing
A35E_RS02445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A35E_RS02450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A35E_RS02455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A35E_RS02455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A35E_RS02460	COG3715	PTS system
A35E_RS02465	COG3716	PTS system mannose fructose sorbose family IID component
A35E_RS02470	COG1862	Preprotein translocase
A35E_RS02475	COG0343	queuine tRNA-ribosyltransferase activity
A35E_RS02480	COG1072	(Pantothenic acid kinase))
A35E_RS02485	COG0308	aminopeptidase N
A35E_RS02490	COG4591	ABC-type transport system involved in lipoprotein release permease component
A35E_RS02495	COG1136	(ABC) transporter
A35E_RS02500	COG4591	ABC-type transport system involved in lipoprotein release permease component
A35E_RS02510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A35E_RS02515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A35E_RS02520	COG0339	signal peptide processing
A35E_RS02525	COG0572	uridine kinase
A35E_RS02530	COG0210	DNA helicase
A35E_RS02540	COG1846	Transcriptional regulator
A35E_RS02545	COG0586	Pfam SNARE associated Golgi protein
A35E_RS02550	COG1160	GTP binding
A35E_RS02555	COG1028	Short-chain dehydrogenase reductase Sdr
A35E_RS02560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A35E_RS02570	COG2969	positive regulation of protein catabolic process
A35E_RS02575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A35E_RS02580	COG2925	Exonuclease
A35E_RS02585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A35E_RS02590	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A35E_RS02595	COG0268	Binds directly to 16S ribosomal RNA
A35E_RS02605	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A35E_RS02610	COG0741	lytic transglycosylase activity
A35E_RS02615	COG0544	peptidyl-prolyl cis-trans isomerase activity
A35E_RS02620	COG1663	tetraacyldisaccharide 4'-kinase activity
A35E_RS02625	COG1132	(ABC) transporter
A35E_RS02645	COG2918	glutathione biosynthetic process
A35E_RS02650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A35E_RS02660	COG0756	dUTP diphosphatase activity
A35E_RS02665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A35E_RS02675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A35E_RS02680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A35E_RS02695	COG0187	DNA topoisomerase II activity
A35E_RS02700	COG0716	FMN binding
A35E_RS02705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A35E_RS02710	COG0416	fatty acid biosynthetic process
A35E_RS02715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A35E_RS02725	COG1028	Short-chain dehydrogenase reductase Sdr
A35E_RS02730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A35E_RS02740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A35E_RS02745	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A35E_RS02750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A35E_RS02755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A35E_RS02760	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A35E_RS02765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A35E_RS02770	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A35E_RS02775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A35E_RS02785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A35E_RS02790	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A35E_RS02805	COG0779	Required for maturation of 30S ribosomal subunits
A35E_RS02810	COG0195	Participates in both transcription termination and antitermination
A35E_RS02815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A35E_RS02820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A35E_RS02825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A35E_RS02830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A35E_RS02835	COG1185	polyribonucleotide nucleotidyltransferase activity
A35E_RS02840	COG0513	Belongs to the DEAD box helicase family
A35E_RS02845	COG0084	hydrolase, TatD family'
A35E_RS02850	COG0470	DNA polymerase III
A35E_RS02855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A35E_RS02860	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A35E_RS02865	COG1758	RNA polymerase activity
A35E_RS02870	COG0194	GDP metabolic process
A35E_RS02875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A35E_RS02885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A35E_RS02900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A35E_RS02905	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A35E_RS02910	COG1104	cysteine desulfurase activity
A35E_RS02915	COG1959	2 iron, 2 sulfur cluster binding
A35E_RS02945	COG0316	Belongs to the HesB IscA family
A35E_RS02955	COG2937	Belongs to the GPAT DAPAT family
A35E_RS02960	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A35E_RS02960	COG0316	Belongs to the HesB IscA family
A35E_RS02990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A35E_RS03020	COG5567	small periplasmic lipoprotein
A35E_RS03060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A35E_RS03105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A35E_RS03115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A35E_RS03125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A35E_RS03155	COG1678	Uncharacterized ACR, COG1678
A35E_RS03165	COG1067	ATP-dependent peptidase activity