locus-tag	class	description
IAD21_00003	COG0511	ligase activity, forming carbon-carbon bonds
IAD21_00004	COG0393	Putative heavy-metal-binding
IAD21_00008	COG0174	glutamine synthetase
IAD21_00012	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAD21_00013	COG5433	transposase activity
IAD21_00018	COG2205	protein histidine kinase activity
IAD21_00027	COG1695	Transcriptional regulator
IAD21_00028	COG1132	(ABC) transporter
IAD21_00029	COG1132	(ABC) transporter
IAD21_00033	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAD21_00034	COG1116	anion transmembrane transporter activity
IAD21_00035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAD21_00036	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAD21_00037	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAD21_00038	COG0667	Aldo Keto reductase
IAD21_00039	COG0778	Nitroreductase
IAD21_00044	COG0606	chelatase, subunit chli
IAD21_00051	COG1216	Glycosyl transferase, family 2
IAD21_00054	COG1215	transferase activity, transferring glycosyl groups
IAD21_00055	COG0606	chelatase, subunit chli
IAD21_00059	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IAD21_00063	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAD21_00064	COG3162	membrane
IAD21_00065	COG0728	peptidoglycan biosynthetic process
IAD21_00067	COG1609	Transcriptional regulator
IAD21_00069	COG1063	alcohol dehydrogenase
IAD21_00071	COG0667	Aldo Keto reductase
IAD21_00072	COG3618	amidohydrolase
IAD21_00073	COG1129	ABC transporter
IAD21_00074	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAD21_00079	COG0315	cyclic pyranopterin monophosphate synthase activity
IAD21_00084	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IAD21_00087	COG0423	glycine-tRNA ligase activity
IAD21_00094	COG0443	Heat shock 70 kDa protein
IAD21_00098	COG0484	heat shock protein binding
IAD21_00099	COG0789	Transcriptional regulator
IAD21_00101	COG3253	May function as heme-dependent peroxidase
IAD21_00104	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IAD21_00105	COG0133	tryptophan synthase activity
IAD21_00108	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_00121	COG1609	Transcriptional regulator
IAD21_00123	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_00137	COG1609	Transcriptional regulator
IAD21_00139	COG3291	Pkd domain containing protein
IAD21_00145	COG3534	alpha-L-arabinofuranosidase
IAD21_00147	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IAD21_00156	COG3420	alginic acid biosynthetic process
IAD21_00160	COG4977	sequence-specific DNA binding
IAD21_00161	COG3335	DDE superfamily endonuclease
IAD21_00172	COG0606	chelatase, subunit chli
IAD21_00174	COG1621	beta-fructofuranosidase activity
IAD21_00175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAD21_00176	COG1621	beta-fructofuranosidase activity
IAD21_00177	COG1621	beta-fructofuranosidase activity
IAD21_00180	COG1609	Transcriptional regulator
IAD21_00188	COG1404	Belongs to the peptidase S8 family
IAD21_00223	COG0606	chelatase, subunit chli
IAD21_00226	COG0606	chelatase, subunit chli
IAD21_00233	COG1136	(ABC) transporter
IAD21_00233	COG0577	efflux transmembrane transporter activity
IAD21_00234	COG1136	(ABC) transporter
IAD21_00234	COG0577	efflux transmembrane transporter activity
IAD21_00235	COG0577	efflux transmembrane transporter activity
IAD21_00235	COG1136	(ABC) transporter
IAD21_00239	COG0606	chelatase, subunit chli
IAD21_00265	COG3250	beta-galactosidase activity
IAD21_00276	COG4249	Peptidase C14 caspase catalytic subunit p20
IAD21_00276	COG2319	Wd-40 repeat
IAD21_00285	COG0747	negative chemotaxis
IAD21_00300	COG3385	transposase activity
IAD21_00306	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_00311	COG1132	(ABC) transporter
IAD21_00312	COG3306	glycosyltransferase involved in LPS biosynthesis
IAD21_00315	COG1213	nucleotidyl transferase
IAD21_00338	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_00339	COG1940	carbohydrate kinase activity
IAD21_00340	COG4821	SIS domain
IAD21_00343	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAD21_00345	COG0673	inositol 2-dehydrogenase activity
IAD21_00346	COG0673	inositol 2-dehydrogenase activity
IAD21_00347	COG3415	Transposase
IAD21_00347	COG2801	Transposase and inactivated derivatives
IAD21_00353	COG1609	Transcriptional regulator
IAD21_00361	COG2197	response regulator
IAD21_00362	COG4585	Histidine kinase
IAD21_00368	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_00369	COG0717	Belongs to the dCTP deaminase family
IAD21_00377	COG0538	isocitrate dehydrogenase activity
IAD21_00385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAD21_00388	COG3206	protein involved in exopolysaccharide biosynthesis
IAD21_00388	COG0489	protein tyrosine kinase activity
IAD21_00392	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAD21_00395	COG2192	nodulation
IAD21_00396	COG0297	glycogen (starch) synthase activity
IAD21_00401	COG0438	transferase activity, transferring glycosyl groups
IAD21_00407	COG0438	transferase activity, transferring glycosyl groups
IAD21_00408	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAD21_00411	COG0367	asparagine synthase
IAD21_00415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IAD21_00422	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAD21_00428	COG0644	oxidoreductase
IAD21_00431	COG2186	Transcriptional regulator
IAD21_00441	COG3177	Filamentation induced by cAMP protein fic
IAD21_00452	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAD21_00457	COG0673	inositol 2-dehydrogenase activity
IAD21_00460	COG1609	Transcriptional regulator
IAD21_00474	COG0590	tRNA wobble adenosine to inosine editing
IAD21_00492	COG1132	(ABC) transporter
IAD21_00493	COG1132	(ABC) transporter
IAD21_00496	COG2165	general secretion pathway protein
IAD21_00502	COG2815	serine threonine protein kinase
IAD21_00502	COG0515	serine threonine protein kinase
IAD21_00507	COG0577	efflux transmembrane transporter activity
IAD21_00507	COG1136	(ABC) transporter
IAD21_00508	COG1136	(ABC) transporter
IAD21_00518	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_00528	COG5002	protein histidine kinase activity
IAD21_00529	COG4249	Peptidase C14 caspase catalytic subunit p20
IAD21_00529	COG2319	Wd-40 repeat
IAD21_00556	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IAD21_00563	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAD21_00618	COG1475	DNA binding
IAD21_00636	COG1846	Transcriptional regulator
IAD21_00649	COG2205	protein histidine kinase activity
IAD21_00650	COG2197	response regulator
IAD21_00712	COG1278	Cold shock
IAD21_00715	COG0745	RESPONSE REGULATOR receiver
IAD21_00735	COG3119	arylsulfatase activity
IAD21_00741	COG1472	Belongs to the glycosyl hydrolase 3 family
IAD21_00742	COG1609	Transcriptional regulator
IAD21_00757	COG1609	Transcriptional regulator
IAD21_00771	COG2801	Transposase and inactivated derivatives
IAD21_00772	COG1609	Transcriptional regulator
IAD21_00775	COG3250	beta-galactosidase activity
IAD21_00779	COG0673	inositol 2-dehydrogenase activity
IAD21_00782	COG2207	Transcriptional regulator
IAD21_00782	COG1917	Cupin 2, conserved barrel domain protein
IAD21_00784	COG0673	inositol 2-dehydrogenase activity
IAD21_00789	COG1609	Transcriptional regulator
IAD21_00791	COG1609	Transcriptional regulator
IAD21_00794	COG3537	Alpha-1,2-mannosidase
IAD21_00832	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAD21_00839	COG1121	(ABC) transporter
IAD21_00842	COG4977	sequence-specific DNA binding
IAD21_00848	COG3093	addiction module antidote protein HigA
IAD21_00857	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAD21_00862	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IAD21_00864	COG4974	Belongs to the 'phage' integrase family
IAD21_00904	COG1783	phage Terminase large subunit
IAD21_00930	COG3409	Peptidoglycan-binding domain 1 protein
IAD21_00959	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IAD21_00960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAD21_00961	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IAD21_00962	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAD21_00963	COG0356	it plays a direct role in the translocation of protons across the membrane
IAD21_00967	COG1562	ergosterol biosynthetic process
IAD21_00968	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IAD21_00978	COG3842	ATPase activity
IAD21_00980	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAD21_00981	COG2304	oxidoreductase activity
IAD21_00986	COG3588	fructose-bisphosphate aldolase
IAD21_00989	COG0653	protein targeting
IAD21_00989	COG0653	protein targeting
IAD21_00998	COG3663	DNA glycosylase
IAD21_01000	COG2897	thiosulfate sulfurtransferase activity
IAD21_01001	COG2197	response regulator
IAD21_01004	COG0359	binds to the 23S rRNA
IAD21_01012	COG1136	(ABC) transporter
IAD21_01015	COG0165	Argininosuccinate lyase
IAD21_01016	COG1472	Belongs to the glycosyl hydrolase 3 family
IAD21_01020	COG0431	NADPH-dependent FMN reductase
IAD21_01025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAD21_01026	COG2226	methyltransferase
IAD21_01028	COG2165	general secretion pathway protein
IAD21_01032	COG1058	Belongs to the CinA family
IAD21_01032	COG1546	Belongs to the CinA family
IAD21_01035	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IAD21_01039	COG0802	atpase or kinase
IAD21_01044	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IAD21_01048	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAD21_01049	COG0243	molybdopterin cofactor binding
IAD21_01051	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAD21_01051	COG1116	anion transmembrane transporter activity
IAD21_01053	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAD21_01053	COG1116	anion transmembrane transporter activity
IAD21_01074	COG0437	4 iron, 4 sulfur cluster binding
IAD21_01076	COG0109	protoheme IX farnesyltransferase activity
IAD21_01076	COG1612	heme a metabolic process
IAD21_01078	COG1309	transcriptional regulator
IAD21_01091	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAD21_01107	COG3842	ATPase activity
IAD21_01111	COG0395	ABC-type sugar transport system, permease component
IAD21_01114	COG4537	Required for transformation and DNA binding
IAD21_01115	COG0247	lactate metabolic process
IAD21_01116	COG1139	Iron-sulfur cluster binding protein
IAD21_01117	COG1556	Lactate utilization protein
IAD21_01118	COG3254	rhamnose metabolic process
IAD21_01119	COG4952	isomerase
IAD21_01120	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_01120	COG3347	Dehydrogenase
IAD21_01122	COG1132	(ABC) transporter
IAD21_01123	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IAD21_01128	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IAD21_01132	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAD21_01133	COG0741	lytic transglycosylase activity
IAD21_01144	COG3250	beta-galactosidase activity
IAD21_01150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IAD21_01151	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAD21_01154	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAD21_01161	COG0544	peptidyl-prolyl cis-trans isomerase activity
IAD21_01163	COG0740	serine-type endopeptidase activity
IAD21_01175	COG0864	Transcriptional regulator
IAD21_01192	COG0038	chloride channel
IAD21_01193	COG0667	Aldo Keto reductase
IAD21_01197	COG0686	Belongs to the AlaDH PNT family
IAD21_01198	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAD21_01199	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAD21_01200	COG0509	glycine decarboxylation via glycine cleavage system
IAD21_01201	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAD21_01247	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAD21_01250	COG1943	Transposase
IAD21_01253	COG2890	protein-(glutamine-N5) methyltransferase activity
IAD21_01254	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IAD21_01257	COG1090	epimerase
IAD21_01261	COG0431	NADPH-dependent FMN reductase
IAD21_01273	COG2204	response regulator
IAD21_01277	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IAD21_01278	COG4956	integral membrane protein (PIN domain superfamily)
IAD21_01279	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IAD21_01280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IAD21_01281	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IAD21_01284	COG0463	Glycosyl transferase, family 2
IAD21_01284	COG1216	Glycosyl transferase, family 2
IAD21_01285	COG0671	phosphoesterase, PA-phosphatase related
IAD21_01290	COG0495	leucyl-tRNA aminoacylation
IAD21_01297	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IAD21_01305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAD21_01306	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IAD21_01307	COG0402	S-adenosylhomocysteine deaminase activity
IAD21_01311	COG0537	adenosine 5'-monophosphoramidase activity
IAD21_01312	COG0504	CTP synthase activity
IAD21_01313	COG1970	mechanosensitive ion channel activity
IAD21_01314	COG0784	Response regulator, receiver
IAD21_01314	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAD21_01314	COG2205	protein histidine kinase activity
IAD21_01314	COG2198	Histidine kinase
IAD21_01323	COG1252	NADH dehydrogenase
IAD21_01326	COG0542	response to heat
IAD21_01328	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAD21_01329	COG3693	PFAM glycoside hydrolase, family 10
IAD21_01333	COG0322	excinuclease ABC activity
IAD21_01335	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_01339	COG0745	RESPONSE REGULATOR receiver
IAD21_01342	COG0432	Pfam Uncharacterised protein family UPF0047
IAD21_01346	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IAD21_01347	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAD21_01348	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IAD21_01349	COG1994	Peptidase M50
IAD21_01354	COG0019	diaminopimelate decarboxylase activity
IAD21_01355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_01356	COG1088	dTDP-glucose 4,6-dehydratase activity
IAD21_01361	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAD21_01362	COG3940	Belongs to the glycosyl hydrolase 43 family
IAD21_01364	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IAD21_01367	COG0667	Aldo Keto reductase
IAD21_01369	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IAD21_01372	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAD21_01377	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IAD21_01379	COG0460	homoserine dehydrogenase
IAD21_01382	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAD21_01383	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAD21_01384	COG0573	inorganic phosphate transmembrane transporter activity
IAD21_01385	COG0581	inorganic phosphate transmembrane transporter activity
IAD21_01386	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAD21_01387	COG0704	Plays a role in the regulation of phosphate uptake
IAD21_01391	COG2205	protein histidine kinase activity
IAD21_01391	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAD21_01391	COG0784	Response regulator, receiver
IAD21_01391	COG2198	Histidine kinase
IAD21_01392	COG1234	tRNA 3'-trailer cleavage
IAD21_01396	COG1053	succinate dehydrogenase
IAD21_01397	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IAD21_01405	COG0745	RESPONSE REGULATOR receiver
IAD21_01411	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IAD21_01413	COG0673	inositol 2-dehydrogenase activity
IAD21_01414	COG0494	nUDIX hydrolase
IAD21_01417	COG2319	Wd-40 repeat
IAD21_01419	COG0205	6-phosphofructokinase activity
IAD21_01421	COG2188	Transcriptional regulator
IAD21_01422	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IAD21_01423	COG0673	inositol 2-dehydrogenase activity
IAD21_01427	COG0180	Tryptophanyl-tRNA synthetase
IAD21_01430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IAD21_01433	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAD21_01434	COG1187	pseudouridine synthase activity
IAD21_01435	COG1686	Belongs to the peptidase S11 family
IAD21_01439	COG0642	Histidine kinase
IAD21_01446	COG3876	Protein conserved in bacteria
IAD21_01448	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IAD21_01449	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAD21_01452	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IAD21_01454	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAD21_01459	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IAD21_01461	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAD21_01462	COG1120	ATPase activity
IAD21_01469	COG1132	(ABC) transporter
IAD21_01472	COG3361	conserved protein (COG2071)
IAD21_01474	COG4124	Belongs to the glycosyl hydrolase 26 family
IAD21_01479	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_01480	COG0724	RNA recognition motif
IAD21_01483	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAD21_01485	COG1074	ATP-dependent DNA helicase activity
IAD21_01492	COG3290	protein histidine kinase activity
IAD21_01493	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IAD21_01495	COG0514	ATP-dependent DNA helicase (RecQ)
IAD21_01499	COG1217	gtp-binding protein TYPA
IAD21_01508	COG1137	ATPase activity
IAD21_01515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAD21_01517	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IAD21_01518	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_01522	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IAD21_01524	COG0528	UMP kinase activity
IAD21_01529	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAD21_01533	COG2267	carboxylic ester hydrolase activity
IAD21_01534	COG3119	arylsulfatase activity
IAD21_01540	COG0440	acetolactate synthase activity
IAD21_01541	COG0028	Belongs to the TPP enzyme family
IAD21_01543	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_01544	COG1309	transcriptional regulator
IAD21_01548	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IAD21_01550	COG0195	Participates in both transcription termination and antitermination
IAD21_01559	COG0823	Involved in the tonB-independent uptake of proteins
IAD21_01559	COG1506	peptidase
IAD21_01560	COG0793	Belongs to the peptidase S41A family
IAD21_01566	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAD21_01571	COG3250	beta-galactosidase activity
IAD21_01577	COG2091	lysine biosynthetic process via aminoadipic acid
IAD21_01579	COG0318	PFAM AMP-dependent synthetase and ligase
IAD21_01592	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAD21_01594	COG3665	Urea carboxylase-associated protein
IAD21_01596	COG0439	Biotin carboxylase
IAD21_01607	COG1937	Protein conserved in bacteria
IAD21_01608	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IAD21_01615	COG3250	beta-galactosidase activity
IAD21_01617	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAD21_01621	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAD21_01623	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IAD21_01626	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IAD21_01630	COG1473	amidohydrolase
IAD21_01632	COG2226	methyltransferase
IAD21_01633	COG0572	uridine kinase
IAD21_01634	COG0632	four-way junction helicase activity
IAD21_01641	COG1132	(ABC) transporter
IAD21_01643	COG1690	Belongs to the RtcB family
IAD21_01650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAD21_01652	COG1621	beta-fructofuranosidase activity
IAD21_01653	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAD21_01654	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAD21_01663	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAD21_01663	COG0574	Belongs to the PEP-utilizing enzyme family
IAD21_01664	COG3940	Belongs to the glycosyl hydrolase 43 family
IAD21_01666	COG0438	transferase activity, transferring glycosyl groups
IAD21_01667	COG0233	cytoplasmic translational termination
IAD21_01668	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAD21_01670	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAD21_01672	COG2199	diguanylate cyclase activity
IAD21_01672	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IAD21_01673	COG0612	Peptidase, M16
IAD21_01674	COG1573	uracil-dna glycosylase
IAD21_01675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IAD21_01678	COG1917	Cupin 2, conserved barrel domain protein
IAD21_01678	COG2207	Transcriptional regulator
IAD21_01680	COG0366	Alpha amylase catalytic
IAD21_01683	COG0297	glycogen (starch) synthase activity
IAD21_01685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAD21_01688	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_01689	COG0601	transmembrane transport
IAD21_01690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAD21_01694	COG0512	Glutamine amidotransferase of anthranilate synthase
IAD21_01696	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IAD21_01697	COG0134	indole-3-glycerol-phosphate synthase activity
IAD21_01698	COG4124	Belongs to the glycosyl hydrolase 26 family
IAD21_01698	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IAD21_01699	COG0133	tryptophan synthase activity
IAD21_01703	COG1305	Transglutaminase-like
IAD21_01705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IAD21_01707	COG0745	RESPONSE REGULATOR receiver
IAD21_01709	COG1063	alcohol dehydrogenase
IAD21_01711	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAD21_01715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IAD21_01723	COG1085	galactose-1-phosphate uridylyltransferase
IAD21_01725	COG0166	Belongs to the GPI family
IAD21_01729	COG0070	glutamate synthase
IAD21_01729	COG0069	glutamate synthase activity
IAD21_01729	COG0067	glutamate synthase
IAD21_01732	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAD21_01738	COG1595	DNA-templated transcription, initiation
IAD21_01744	COG0235	Class ii aldolase
IAD21_01745	COG1069	ribulokinase activity
IAD21_01746	COG1063	alcohol dehydrogenase
IAD21_01748	COG2160	L-arabinose isomerase activity
IAD21_01749	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAD21_01750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAD21_01759	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
IAD21_01760	COG1231	oxidoreductase activity
IAD21_01763	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAD21_01764	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IAD21_01765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IAD21_01765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IAD21_01768	COG1609	Transcriptional regulator
IAD21_01770	COG1748	Saccharopine dehydrogenase
IAD21_01772	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAD21_01773	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_01776	COG1695	Transcriptional regulator
IAD21_01780	COG4122	O-methyltransferase activity
IAD21_01783	COG5433	transposase activity
IAD21_01797	COG0346	lactoylglutathione lyase activity
IAD21_01798	COG2217	Heavy metal translocating P-type atpase
IAD21_01804	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAD21_01806	COG0314	molybdopterin synthase activity
IAD21_01808	COG1199	ATP-dependent helicase activity
IAD21_01809	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAD21_01809	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAD21_01810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IAD21_01812	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IAD21_01812	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAD21_01816	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAD21_01816	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAD21_01822	COG0745	RESPONSE REGULATOR receiver
IAD21_01823	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAD21_01824	COG5183	chlorophyll binding
IAD21_01824	COG2133	pyrroloquinoline quinone binding
IAD21_01825	COG5002	protein histidine kinase activity
IAD21_01843	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAD21_01845	COG2852	Protein conserved in bacteria
IAD21_01848	COG0646	methionine synthase
IAD21_01848	COG1410	methionine synthase
IAD21_01849	COG3629	intracellular signal transduction
IAD21_01849	COG3903	Transcriptional regulator
IAD21_01853	COG0584	glycerophosphoryl diester phosphodiesterase
IAD21_01854	COG0673	inositol 2-dehydrogenase activity
IAD21_01859	COG0791	NLP P60 protein
IAD21_01860	COG1040	competence protein
IAD21_01863	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAD21_01872	COG2348	transferase activity, transferring amino-acyl groups
IAD21_01873	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IAD21_01874	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAD21_01875	COG1215	transferase activity, transferring glycosyl groups
IAD21_01876	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IAD21_01887	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAD21_01888	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAD21_01890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IAD21_01892	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAD21_01894	COG0750	zinc metalloprotease
IAD21_01897	COG5285	phytanoyl-CoA dioxygenase
IAD21_01909	COG0175	sulfate reduction
IAD21_01916	COG0442	prolyl-tRNA aminoacylation
IAD21_01920	COG1695	Transcriptional regulator
IAD21_01921	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAD21_01925	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IAD21_01931	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IAD21_01933	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_01934	COG1959	2 iron, 2 sulfur cluster binding
IAD21_01935	COG1902	pentaerythritol trinitrate reductase activity
IAD21_01936	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_01937	COG1064	alcohol dehydrogenase
IAD21_01940	COG1063	alcohol dehydrogenase
IAD21_01941	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_01945	COG0673	inositol 2-dehydrogenase activity
IAD21_01946	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IAD21_01952	COG0778	Nitroreductase
IAD21_01953	COG0477	Major facilitator Superfamily
IAD21_01955	COG0285	dihydrofolate synthase activity
IAD21_01958	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IAD21_01959	COG0667	Aldo Keto reductase
IAD21_01960	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IAD21_01961	COG0443	Heat shock 70 kDa protein
IAD21_01963	COG2340	Cysteine-rich secretory protein family
IAD21_01970	COG0322	excinuclease ABC activity
IAD21_01973	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAD21_01975	COG1418	mRNA catabolic process
IAD21_01976	COG2359	stage V sporulation protein S
IAD21_01978	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IAD21_01979	COG0287	Prephenate dehydrogenase
IAD21_01980	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IAD21_01981	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAD21_01983	COG0484	heat shock protein binding
IAD21_01984	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IAD21_01989	COG0148	phosphopyruvate hydratase activity
IAD21_01993	COG3119	arylsulfatase activity
IAD21_01994	COG0215	cysteine-tRNA ligase activity
IAD21_01998	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAD21_02002	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAD21_02020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAD21_02024	COG2815	serine threonine protein kinase
IAD21_02024	COG0515	serine threonine protein kinase
IAD21_02036	COG1131	(ABC) transporter
IAD21_02037	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IAD21_02044	COG1819	glycosyl
IAD21_02045	COG0628	permease
IAD21_02046	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_02051	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IAD21_02056	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAD21_02061	COG0463	Glycosyl transferase, family 2
IAD21_02066	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IAD21_02067	COG2843	Capsule synthesis protein
IAD21_02070	COG2205	protein histidine kinase activity
IAD21_02075	COG0196	riboflavin kinase activity
IAD21_02077	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IAD21_02080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IAD21_02084	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IAD21_02085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IAD21_02089	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAD21_02097	COG0586	Pfam SNARE associated Golgi protein
IAD21_02100	COG1487	ribonuclease activity
IAD21_02102	COG0542	response to heat
IAD21_02103	COG2169	Transcriptional regulator
IAD21_02103	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAD21_02107	COG0501	Belongs to the peptidase M48B family
IAD21_02108	COG0577	efflux transmembrane transporter activity
IAD21_02109	COG0745	RESPONSE REGULATOR receiver
IAD21_02112	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAD21_02116	COG0463	Glycosyl transferase, family 2
IAD21_02117	COG0416	fatty acid biosynthetic process
IAD21_02125	COG0758	DNA mediated transformation
IAD21_02125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAD21_02126	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IAD21_02128	COG2326	polyphosphate kinase activity
IAD21_02133	COG0745	RESPONSE REGULATOR receiver
IAD21_02134	COG2205	protein histidine kinase activity
IAD21_02138	COG1196	nuclear chromosome segregation
IAD21_02149	COG2719	SpoVR family
IAD21_02151	COG2718	Belongs to the UPF0229 family
IAD21_02152	COG2766	serine protein kinase
IAD21_02154	COG2272	Belongs to the type-B carboxylesterase lipase family
IAD21_02155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAD21_02157	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IAD21_02159	COG1515	deoxyribonuclease V activity
IAD21_02164	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAD21_02165	COG0747	negative chemotaxis
IAD21_02168	COG4172	Belongs to the ABC transporter superfamily
IAD21_02173	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAD21_02173	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAD21_02176	COG4464	protein tyrosine phosphatase activity
IAD21_02180	COG0095	Lipoate-protein ligase
IAD21_02182	COG2815	serine threonine protein kinase
IAD21_02182	COG0515	serine threonine protein kinase
IAD21_02185	COG0018	arginyl-trna synthetase
IAD21_02186	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAD21_02188	COG0004	ammonium transporteR
IAD21_02192	COG0174	glutamine synthetase
IAD21_02194	COG0010	Belongs to the arginase family
IAD21_02196	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IAD21_02196	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IAD21_02197	COG0772	Belongs to the SEDS family
IAD21_02205	COG5433	transposase activity
IAD21_02209	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAD21_02211	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAD21_02212	COG0037	tRNA processing
IAD21_02213	COG2062	phosphohistidine phosphatase, SixA
IAD21_02224	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
IAD21_02229	COG0163	prenyltransferase activity
IAD21_02231	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IAD21_02236	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAD21_02237	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IAD21_02241	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IAD21_02243	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IAD21_02244	COG0268	Binds directly to 16S ribosomal RNA
IAD21_02248	COG0328	RNA-DNA hybrid ribonuclease activity
IAD21_02251	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IAD21_02252	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAD21_02261	COG0156	8-amino-7-oxononanoate synthase activity
IAD21_02263	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IAD21_02271	COG0552	protein localization to endoplasmic reticulum
IAD21_02272	COG2199	diguanylate cyclase activity
IAD21_02272	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IAD21_02277	COG1450	Type ii and iii secretion system protein
IAD21_02279	COG1253	flavin adenine dinucleotide binding
IAD21_02295	COG0254	rRNA binding
IAD21_02296	COG1088	dTDP-glucose 4,6-dehydratase activity
IAD21_02302	COG0745	RESPONSE REGULATOR receiver
IAD21_02312	COG5001	Diguanylate cyclase
IAD21_02313	COG1164	Oligoendopeptidase f
IAD21_02317	COG1136	(ABC) transporter
IAD21_02317	COG0577	efflux transmembrane transporter activity
IAD21_02322	COG2967	ApaG domain
IAD21_02325	COG0768	penicillin binding
IAD21_02326	COG3385	transposase activity
IAD21_02328	COG4974	Belongs to the 'phage' integrase family
IAD21_02330	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IAD21_02333	COG2835	tetraacyldisaccharide 4'-kinase activity
IAD21_02344	COG0352	thiamine-phosphate diphosphorylase activity
IAD21_02346	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAD21_02347	COG1372	Participates in initiation and elongation during chromosome replication
IAD21_02347	COG0187	DNA topoisomerase II activity
IAD21_02350	COG4964	Belongs to the GSP D family
IAD21_02352	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IAD21_02354	COG0546	phosphoglycolate phosphatase activity
IAD21_02360	COG0393	Putative heavy-metal-binding
IAD21_02363	COG2154	pterin-4-alpha-carbinolamine dehydratase
IAD21_02365	COG2223	nitrite transmembrane transporter activity
IAD21_02369	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IAD21_02370	COG1185	polyribonucleotide nucleotidyltransferase activity
IAD21_02376	COG4566	intracellular signal transduction
IAD21_02379	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_02382	COG2199	diguanylate cyclase activity
IAD21_02382	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IAD21_02383	COG4636	protein conserved in cyanobacteria
IAD21_02384	COG2264	protein methyltransferase activity
IAD21_02385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IAD21_02387	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IAD21_02389	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAD21_02406	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IAD21_02407	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IAD21_02411	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IAD21_02449	COG5433	transposase activity
IAD21_02457	COG3250	beta-galactosidase activity
IAD21_02458	COG3250	beta-galactosidase activity
IAD21_02459	COG3250	beta-galactosidase activity
IAD21_02461	COG1609	Transcriptional regulator
IAD21_02462	COG3250	beta-galactosidase activity
IAD21_02467	COG1278	Cold shock
IAD21_02468	COG2096	Adenosyltransferase
IAD21_02469	COG5002	protein histidine kinase activity
IAD21_02470	COG0745	RESPONSE REGULATOR receiver
IAD21_02471	COG2226	methyltransferase
IAD21_02472	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IAD21_02480	COG3583	domain protein
IAD21_02480	COG3584	3D domain protein
IAD21_02482	COG3781	membrane
IAD21_02484	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IAD21_02487	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IAD21_02489	COG0640	Transcriptional regulator
IAD21_02493	COG3706	GGDEF domain
IAD21_02499	COG1064	alcohol dehydrogenase
IAD21_02505	COG2124	cytochrome p450
IAD21_02507	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IAD21_02509	COG0602	queuosine metabolic process
IAD21_02511	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IAD21_02513	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IAD21_02514	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IAD21_02515	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAD21_02517	COG1609	Transcriptional regulator
IAD21_02518	COG3250	beta-galactosidase activity
IAD21_02520	COG0583	DNA-binding transcription factor activity
IAD21_02521	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAD21_02523	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IAD21_02525	COG4191	Histidine kinase
IAD21_02532	COG2273	Hydrolase Family 16
IAD21_02532	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IAD21_02547	COG1215	transferase activity, transferring glycosyl groups
IAD21_02550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IAD21_02552	COG0765	amino acid transport
IAD21_02554	COG1501	Belongs to the glycosyl hydrolase 31 family
IAD21_02557	COG1609	Transcriptional regulator
IAD21_02558	COG0656	L-ascorbic acid biosynthetic process
IAD21_02568	COG0577	efflux transmembrane transporter activity
IAD21_02568	COG1136	(ABC) transporter
IAD21_02569	COG1136	(ABC) transporter
IAD21_02571	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAD21_02573	COG0745	RESPONSE REGULATOR receiver
IAD21_02577	COG1301	dicarboxylic acid transport
IAD21_02580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAD21_02581	COG0629	single-stranded DNA binding
IAD21_02582	COG0360	Binds together with S18 to 16S ribosomal RNA
IAD21_02587	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IAD21_02587	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAD21_02589	COG0415	Belongs to the DNA photolyase family
IAD21_02590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAD21_02595	COG0529	Catalyzes the synthesis of activated sulfate
IAD21_02596	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
IAD21_02597	COG0210	DNA helicase
IAD21_02598	COG0438	transferase activity, transferring glycosyl groups
IAD21_02599	COG0438	transferase activity, transferring glycosyl groups
IAD21_02599	COG0438	transferase activity, transferring glycosyl groups
IAD21_02600	COG1611	Belongs to the LOG family
IAD21_02603	COG0412	Dienelactone hydrolase
IAD21_02606	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IAD21_02612	COG2205	protein histidine kinase activity
IAD21_02612	COG0784	Response regulator, receiver
IAD21_02613	COG0784	Response regulator, receiver
IAD21_02614	COG4251	negative regulation of phosphorylation
IAD21_02615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAD21_02621	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IAD21_02625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_02626	COG0673	inositol 2-dehydrogenase activity
IAD21_02635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IAD21_02637	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAD21_02638	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAD21_02639	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IAD21_02640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IAD21_02645	COG0768	penicillin binding
IAD21_02648	COG2001	Belongs to the MraZ family
IAD21_02658	COG4122	O-methyltransferase activity
IAD21_02659	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_02660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAD21_02664	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IAD21_02667	COG1846	Transcriptional regulator
IAD21_02668	COG1566	PFAM secretion protein HlyD family protein
IAD21_02669	COG2814	Major facilitator Superfamily
IAD21_02673	COG2135	peptidase activity
IAD21_02677	COG1070	Carbohydrate kinase
IAD21_02678	COG2207	Transcriptional regulator
IAD21_02686	COG0205	6-phosphofructokinase activity
IAD21_02691	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_02696	COG5002	protein histidine kinase activity
IAD21_02697	COG0438	transferase activity, transferring glycosyl groups
IAD21_02698	COG1216	Glycosyl transferase, family 2
IAD21_02700	COG0463	Glycosyl transferase, family 2
IAD21_02700	COG1216	Glycosyl transferase, family 2
IAD21_02708	COG1321	iron dependent repressor
IAD21_02711	COG1129	ABC transporter
IAD21_02712	COG0546	phosphoglycolate phosphatase activity
IAD21_02716	COG2267	carboxylic ester hydrolase activity
IAD21_02717	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_02720	COG5001	Diguanylate cyclase
IAD21_02722	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IAD21_02725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IAD21_02727	COG0109	protoheme IX farnesyltransferase activity
IAD21_02733	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IAD21_02735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAD21_02739	COG0745	RESPONSE REGULATOR receiver
IAD21_02743	COG3214	Protein conserved in bacteria
IAD21_02745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IAD21_02746	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IAD21_02752	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IAD21_02755	COG0583	DNA-binding transcription factor activity
IAD21_02758	COG4122	O-methyltransferase activity
IAD21_02760	COG0438	transferase activity, transferring glycosyl groups
IAD21_02760	COG0297	glycogen (starch) synthase activity
IAD21_02761	COG0297	glycogen (starch) synthase activity
IAD21_02765	COG0438	transferase activity, transferring glycosyl groups
IAD21_02775	COG0438	transferase activity, transferring glycosyl groups
IAD21_02776	COG2244	polysaccharide biosynthetic process
IAD21_02792	COG1609	Transcriptional regulator
IAD21_02795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IAD21_02795	COG1796	DNA polymerase
IAD21_02800	COG0123	including yeast histone deacetylase and acetoin utilization protein
IAD21_02801	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IAD21_02803	COG0484	heat shock protein binding
IAD21_02804	COG1459	type II secretion system
IAD21_02805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IAD21_02806	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IAD21_02811	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IAD21_02815	COG0783	Belongs to the Dps family
IAD21_02821	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAD21_02836	COG0784	Response regulator, receiver
IAD21_02836	COG2205	protein histidine kinase activity
IAD21_02836	COG5002	protein histidine kinase activity
IAD21_02837	COG0745	RESPONSE REGULATOR receiver
IAD21_02844	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IAD21_02845	COG0830	nickel cation binding
IAD21_02849	COG0804	urea catabolic process
IAD21_02850	COG0832	Belongs to the urease beta subunit family
IAD21_02851	COG0831	urea catabolic process
IAD21_02853	COG0411	ABC transporter
IAD21_02860	COG2318	DinB family
IAD21_02868	COG0346	lactoylglutathione lyase activity
IAD21_02870	COG0456	acetyltransferase
IAD21_02885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IAD21_02889	COG5473	translation initiation factor activity
IAD21_02891	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IAD21_02892	COG0459	protein refolding
IAD21_02898	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_02907	COG0006	proline dipeptidase activity
IAD21_02909	COG3706	GGDEF domain
IAD21_02913	COG0800	Aldolase
IAD21_02914	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_02916	COG0673	inositol 2-dehydrogenase activity
IAD21_02918	COG4977	sequence-specific DNA binding
IAD21_02920	COG3852	Histidine kinase
IAD21_02922	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IAD21_02923	COG1192	Involved in chromosome partitioning
IAD21_02925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IAD21_02927	COG0167	dihydroorotate dehydrogenase activity
IAD21_02928	COG0667	Aldo Keto reductase
IAD21_02934	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAD21_02938	COG1051	belongs to the nudix hydrolase family
IAD21_02942	COG0018	arginyl-trna synthetase
IAD21_02949	COG0523	cobalamin synthesis protein
IAD21_02950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAD21_02959	COG0527	aspartate kinase activity
IAD21_02961	COG0515	serine threonine protein kinase
IAD21_02961	COG2815	serine threonine protein kinase
IAD21_02963	COG1959	2 iron, 2 sulfur cluster binding
IAD21_02964	COG0179	Fumarylacetoacetate (FAA) hydrolase
IAD21_02969	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IAD21_02973	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IAD21_02974	COG0628	permease
IAD21_02975	COG1968	undecaprenyl-diphosphatase activity
IAD21_02981	COG3118	belongs to the thioredoxin family
IAD21_02982	COG0470	DNA polymerase III
IAD21_02983	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IAD21_02986	COG3854	ATPases associated with a variety of cellular activities
IAD21_02987	COG1011	Hydrolase
IAD21_02988	COG0489	protein tyrosine kinase activity
IAD21_02991	COG1104	cysteine desulfurase activity
IAD21_02993	COG4989	oxidoreductase activity
IAD21_02994	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IAD21_03000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAD21_03001	COG0154	amidase activity
IAD21_03003	COG3119	arylsulfatase activity
IAD21_03009	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAD21_03011	COG0242	peptide deformylase activity
IAD21_03016	COG0159	tryptophan synthase activity
IAD21_03017	COG1381	Involved in DNA repair and RecF pathway recombination
IAD21_03024	COG0698	ribose 5-phosphate isomerase
IAD21_03025	COG5002	protein histidine kinase activity
IAD21_03029	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IAD21_03031	COG4969	Belongs to the N-Me-Phe pilin family
IAD21_03036	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IAD21_03042	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IAD21_03043	COG0131	Imidazoleglycerol-phosphate dehydratase
IAD21_03045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IAD21_03046	COG1573	uracil-dna glycosylase
IAD21_03048	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAD21_03055	COG3250	beta-galactosidase activity
IAD21_03064	COG1129	ABC transporter
IAD21_03065	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAD21_03066	COG0488	(ABC) transporter
IAD21_03071	COG0612	Peptidase, M16
IAD21_03072	COG2205	protein histidine kinase activity
IAD21_03091	COG1408	metallophosphoesterase
IAD21_03102	COG1609	Transcriptional regulator
IAD21_03103	COG5434	Belongs to the glycosyl hydrolase 28 family
IAD21_03104	COG1215	transferase activity, transferring glycosyl groups
IAD21_03121	COG1940	carbohydrate kinase activity
IAD21_03124	COG0667	Aldo Keto reductase
IAD21_03132	COG0058	SHG alpha-glucan phosphorylase activity
IAD21_03138	COG0647	UMP catabolic process
IAD21_03139	COG0575	Belongs to the CDS family
IAD21_03141	COG0714	Associated with various cellular activities
IAD21_03150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAD21_03152	COG0482	sulfurtransferase activity
IAD21_03156	COG2373	Large extracellular alpha-helical protein
IAD21_03164	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAD21_03173	COG0484	heat shock protein binding
IAD21_03174	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IAD21_03175	COG1420	regulation of RNA biosynthetic process
IAD21_03188	COG0513	Belongs to the DEAD box helicase family
IAD21_03190	COG0668	transmembrane transport
IAD21_03197	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IAD21_03204	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IAD21_03209	COG1408	metallophosphoesterase
IAD21_03210	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAD21_03216	COG0723	plastoquinol--plastocyanin reductase activity
IAD21_03225	COG4783	chaperone-mediated protein folding
IAD21_03227	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAD21_03229	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAD21_03232	COG1136	(ABC) transporter
IAD21_03233	COG0577	efflux transmembrane transporter activity
IAD21_03235	COG1847	R3H domain protein
IAD21_03236	COG0706	membrane insertase activity
IAD21_03237	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IAD21_03246	COG0475	glutathione-regulated potassium exporter activity
IAD21_03247	COG0438	transferase activity, transferring glycosyl groups
IAD21_03248	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IAD21_03257	COG0194	GDP metabolic process
IAD21_03258	COG1595	DNA-templated transcription, initiation
IAD21_03262	COG0004	ammonium transporteR
IAD21_03264	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IAD21_03266	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IAD21_03269	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAD21_03275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAD21_03279	COG3885	ferrous iron binding
IAD21_03279	COG2078	PFAM AMMECR1 domain protein
IAD21_03284	COG1132	(ABC) transporter
IAD21_03286	COG1372	Participates in initiation and elongation during chromosome replication
IAD21_03286	COG0305	Participates in initiation and elongation during chromosome replication
IAD21_03290	COG0151	Belongs to the GarS family
IAD21_03293	COG0047	phosphoribosylformylglycinamidine synthase activity
IAD21_03297	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAD21_03299	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IAD21_03301	COG0497	DNA recombination
IAD21_03302	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IAD21_03303	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IAD21_03307	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAD21_03309	COG1722	exodeoxyribonuclease VII activity
IAD21_03310	COG1570	exodeoxyribonuclease VII activity
IAD21_03318	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IAD21_03322	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IAD21_03330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IAD21_03331	COG0316	Belongs to the HesB IscA family
IAD21_03332	COG5001	Diguanylate cyclase
IAD21_03336	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAD21_03342	COG0084	hydrolase, TatD family'
IAD21_03343	COG4977	sequence-specific DNA binding
IAD21_03354	COG0728	peptidoglycan biosynthetic process
IAD21_03358	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IAD21_03360	COG0750	zinc metalloprotease
IAD21_03361	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IAD21_03364	COG0633	Ferredoxin
IAD21_03364	COG3217	Mosc domain protein beta barrel domain protein
IAD21_03367	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IAD21_03373	COG2304	oxidoreductase activity
IAD21_03375	COG2207	Transcriptional regulator
IAD21_03381	COG0138	bifunctional purine biosynthesis protein purh
IAD21_03389	COG1132	(ABC) transporter
IAD21_03390	COG0009	L-threonylcarbamoyladenylate synthase
IAD21_03396	COG1704	LemA family
IAD21_03400	COG1162	GTPase activity
IAD21_03401	COG2385	sporulation resulting in formation of a cellular spore
IAD21_03402	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAD21_03404	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IAD21_03404	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IAD21_03406	COG0022	dehydrogenase e1 component
IAD21_03406	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAD21_03427	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IAD21_03428	COG1366	Belongs to the anti-sigma-factor antagonist family
IAD21_03429	COG2172	sigma factor antagonist activity
IAD21_03432	COG1733	regulation of RNA biosynthetic process
IAD21_03433	COG0702	epimerase
IAD21_03440	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAD21_03441	COG0564	pseudouridine synthase activity
IAD21_03443	COG0739	heme binding
IAD21_03447	COG3458	cephalosporin-C deacetylase activity
IAD21_03448	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_03452	COG2814	Major facilitator Superfamily
IAD21_03459	COG0667	Aldo Keto reductase
IAD21_03463	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IAD21_03463	COG5297	Belongs to the glycosyl hydrolase family 6
IAD21_03470	COG3250	beta-galactosidase activity
IAD21_03474	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_03482	COG1222	aaa ATPase
IAD21_03486	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IAD21_03489	COG0363	glucosamine-6-phosphate deaminase activity
IAD21_03496	COG2202	Pas domain
IAD21_03496	COG2205	protein histidine kinase activity
IAD21_03499	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IAD21_03500	COG1138	Cytochrome C-type biogenesis protein
IAD21_03504	COG3119	arylsulfatase activity
IAD21_03507	COG0012	GTP binding
IAD21_03511	COG1063	alcohol dehydrogenase
IAD21_03515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAD21_03517	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IAD21_03518	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAD21_03519	COG2890	protein-(glutamine-N5) methyltransferase activity
IAD21_03520	COG0514	ATP-dependent DNA helicase (RecQ)
IAD21_03522	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAD21_03525	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IAD21_03526	COG0540	Belongs to the ATCase OTCase family
IAD21_03530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAD21_03533	COG0505	Belongs to the CarA family
IAD21_03537	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAD21_03539	COG0753	catalase activity
IAD21_03539	COG0693	protein deglycase activity
IAD21_03540	COG1073	alpha beta
IAD21_03542	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IAD21_03550	COG1609	Transcriptional regulator
IAD21_03558	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IAD21_03559	COG0191	fructose-bisphosphate aldolase activity
IAD21_03564	COG5002	protein histidine kinase activity
IAD21_03565	COG0791	NLP P60 protein
IAD21_03573	COG3622	Belongs to the hyi family
IAD21_03578	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IAD21_03581	COG3206	protein involved in exopolysaccharide biosynthesis
IAD21_03582	COG0616	signal peptide processing
IAD21_03585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAD21_03585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAD21_03589	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IAD21_03590	COG0049	tRNA binding
IAD21_03597	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAD21_03599	COG4636	protein conserved in cyanobacteria
IAD21_03602	COG4636	protein conserved in cyanobacteria
IAD21_03607	COG0587	DNA-directed DNA polymerase activity
IAD21_03608	COG1404	Belongs to the peptidase S8 family
IAD21_03610	COG0673	inositol 2-dehydrogenase activity
IAD21_03615	COG1401	restriction endodeoxyribonuclease activity
IAD21_03615	COG1401	restriction endodeoxyribonuclease activity
IAD21_03616	COG0525	valine-tRNA ligase activity
IAD21_03617	COG3548	integral membrane protein
IAD21_03624	COG1609	Transcriptional regulator
IAD21_03627	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IAD21_03628	COG1127	ABC transporter
IAD21_03642	COG0598	Magnesium transport protein CorA
IAD21_03643	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IAD21_03644	COG0673	inositol 2-dehydrogenase activity
IAD21_03645	COG1929	Belongs to the glycerate kinase type-1 family
IAD21_03648	COG0673	inositol 2-dehydrogenase activity
IAD21_03651	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IAD21_03677	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IAD21_03678	COG0110	maltose O-acetyltransferase activity
IAD21_03684	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IAD21_03685	COG0640	Transcriptional regulator
IAD21_03699	COG4974	Belongs to the 'phage' integrase family
IAD21_03701	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IAD21_03758	COG0745	RESPONSE REGULATOR receiver
IAD21_03761	COG4251	negative regulation of phosphorylation
IAD21_03762	COG0784	Response regulator, receiver
IAD21_03763	COG0784	Response regulator, receiver
IAD21_03763	COG2205	protein histidine kinase activity
IAD21_03763	COG2198	Histidine kinase
IAD21_03769	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IAD21_03771	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAD21_03773	COG2208	phosphoserine phosphatase activity
IAD21_03775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAD21_03780	COG0537	adenosine 5'-monophosphoramidase activity
IAD21_03783	COG1691	(AIR) carboxylase
IAD21_03784	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IAD21_03814	COG0811	peptide transport
IAD21_03815	COG0811	peptide transport
IAD21_03816	COG0848	biopolymer transport protein
IAD21_03823	COG1595	DNA-templated transcription, initiation
IAD21_03826	COG0772	Belongs to the SEDS family
IAD21_03827	COG2815	serine threonine protein kinase
IAD21_03827	COG0515	serine threonine protein kinase
IAD21_03829	COG0542	response to heat
IAD21_03830	COG0515	serine threonine protein kinase
IAD21_03830	COG2815	serine threonine protein kinase
IAD21_03841	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IAD21_03847	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IAD21_03851	COG3956	TIGRFAM MazG family protein
IAD21_03853	COG0217	transcriptional regulatory protein
IAD21_03856	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAD21_03859	COG0492	ferredoxin-NADP+ reductase activity
IAD21_03860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAD21_03861	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IAD21_03867	COG1469	GTP cyclohydrolase I activity
IAD21_03869	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IAD21_03869	COG1793	dna ligase
IAD21_03871	COG1793	dna ligase
IAD21_03872	COG3409	Peptidoglycan-binding domain 1 protein
IAD21_03877	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAD21_03882	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAD21_03887	COG0463	Glycosyl transferase, family 2
IAD21_03889	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAD21_03893	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IAD21_03894	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_03897	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAD21_03906	COG1609	Transcriptional regulator
IAD21_03910	COG1609	Transcriptional regulator
IAD21_03914	COG3250	beta-galactosidase activity
IAD21_03918	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IAD21_03919	COG4677	pectinesterase activity
IAD21_03920	COG2271	Major facilitator Superfamily
IAD21_03921	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IAD21_03922	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_03927	COG3537	Alpha-1,2-mannosidase
IAD21_03928	COG4213	ABC transporter substrate-binding protein
IAD21_03929	COG1129	ABC transporter
IAD21_03930	COG4214	carbohydrate transport
IAD21_03931	COG4282	regulation of fungal-type cell wall biogenesis
IAD21_03932	COG0395	ABC-type sugar transport system, permease component
IAD21_03933	COG1175	transmembrane transport
IAD21_03936	COG1609	Transcriptional regulator
IAD21_03939	COG1609	Transcriptional regulator
IAD21_03941	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAD21_03943	COG0419	ATPase involved in DNA repair
IAD21_03945	COG1595	DNA-templated transcription, initiation
IAD21_03946	COG4260	virion core protein, lumpy skin disease virus
IAD21_03947	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IAD21_03949	COG3537	Alpha-1,2-mannosidase
IAD21_03951	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_03953	COG4251	negative regulation of phosphorylation
IAD21_03953	COG3706	GGDEF domain
IAD21_03953	COG2203	Gaf domain
IAD21_03953	COG5001	Diguanylate cyclase
IAD21_03959	COG1070	Carbohydrate kinase
IAD21_03967	COG0284	orotidine-5'-phosphate decarboxylase activity
IAD21_03977	COG0110	maltose O-acetyltransferase activity
IAD21_03985	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_03986	COG1305	Transglutaminase-like
IAD21_03990	COG2308	Evidence 4 Homologs of previously reported genes of
IAD21_03993	COG0628	permease
IAD21_03994	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IAD21_03999	COG0613	PHP domain protein
IAD21_04000	COG0529	Catalyzes the synthesis of activated sulfate
IAD21_04004	COG3872	metal-dependent enzyme
IAD21_04005	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IAD21_04007	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IAD21_04010	COG1331	Highly conserved protein containing a thioredoxin domain
IAD21_04012	COG1051	belongs to the nudix hydrolase family
IAD21_04013	COG1733	regulation of RNA biosynthetic process
IAD21_04014	COG0702	epimerase
IAD21_04017	COG1363	Peptidase, m42
IAD21_04019	COG1335	isochorismatase
IAD21_04020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IAD21_04027	COG0714	Associated with various cellular activities
IAD21_04033	COG4974	Belongs to the 'phage' integrase family
IAD21_04036	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IAD21_04039	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAD21_04040	COG4636	protein conserved in cyanobacteria
IAD21_04043	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IAD21_04045	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IAD21_04047	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IAD21_04049	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAD21_04051	COG2814	Major facilitator Superfamily
IAD21_04056	COG0673	inositol 2-dehydrogenase activity
IAD21_04060	COG3875	lactate racemase activity
IAD21_04069	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IAD21_04077	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IAD21_04079	COG0666	response to abiotic stimulus
IAD21_04086	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IAD21_04087	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IAD21_04090	COG0519	Catalyzes the synthesis of GMP from XMP
IAD21_04090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAD21_04092	COG0516	GMP reductase activity
IAD21_04099	COG2197	response regulator
IAD21_04101	COG2197	response regulator
IAD21_04102	COG4585	Histidine kinase
IAD21_04106	COG0673	inositol 2-dehydrogenase activity
IAD21_04108	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IAD21_04108	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IAD21_04113	COG2195	Cleaves the N-terminal amino acid of tripeptides
IAD21_04115	COG0697	spore germination
IAD21_04116	COG2226	methyltransferase
IAD21_04118	COG0438	transferase activity, transferring glycosyl groups
IAD21_04121	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IAD21_04123	COG5433	transposase activity
IAD21_04124	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IAD21_04126	COG0579	oxidoreductase
IAD21_04127	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IAD21_04144	COG2304	oxidoreductase activity
IAD21_04145	COG2304	oxidoreductase activity
IAD21_04152	COG4245	von Willebrand factor, type A
IAD21_04153	COG4245	von Willebrand factor, type A
IAD21_04158	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IAD21_04160	COG2197	response regulator
IAD21_04161	COG4585	Histidine kinase
IAD21_04163	COG0025	NhaP-type Na H and K H
IAD21_04167	COG1234	tRNA 3'-trailer cleavage
IAD21_04169	COG0726	polysaccharide deacetylase
IAD21_04171	COG1073	alpha beta
IAD21_04180	COG2205	protein histidine kinase activity
IAD21_04183	COG1131	(ABC) transporter
IAD21_04187	COG0354	folic acid binding
IAD21_04190	COG3359	exonuclease
IAD21_04193	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAD21_04194	COG0135	phosphoribosylanthranilate isomerase activity
IAD21_04196	COG1091	dTDP-4-dehydrorhamnose reductase activity
IAD21_04198	COG1803	Methylglyoxal synthase
IAD21_04199	COG1280	lysine exporter protein (LysE YggA)
IAD21_04206	COG0113	porphobilinogen synthase activity
IAD21_04207	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IAD21_04218	COG0181	hydroxymethylbilane synthase activity
IAD21_04220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IAD21_04226	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAD21_04226	COG1648	precorrin-2 dehydrogenase activity
IAD21_04238	COG3459	Glycosyltransferase 36 associated
IAD21_04239	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IAD21_04252	COG1231	oxidoreductase activity
IAD21_04259	COG0714	Associated with various cellular activities
IAD21_04260	COG1305	Transglutaminase-like
IAD21_04263	COG1295	ribonuclease BN
IAD21_04265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IAD21_04266	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_04272	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IAD21_04273	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IAD21_04279	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IAD21_04282	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IAD21_04286	COG0583	DNA-binding transcription factor activity
IAD21_04299	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAD21_04300	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IAD21_04301	COG0861	Integral membrane protein TerC family
IAD21_04302	COG3250	beta-galactosidase activity
IAD21_04303	COG2166	iron-sulfur cluster assembly
IAD21_04304	COG2151	metal-sulfur cluster biosynthetic enzyme
IAD21_04308	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IAD21_04309	COG0358	DNA primase activity
IAD21_04310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAD21_04315	COG0742	ribosomal rna small subunit methyltransferase
IAD21_04319	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IAD21_04320	COG0668	transmembrane transport
IAD21_04323	COG2239	Acts as a magnesium transporter
IAD21_04324	COG2239	Acts as a magnesium transporter
IAD21_04325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IAD21_04328	COG0494	nUDIX hydrolase
IAD21_04331	COG1609	Transcriptional regulator
IAD21_04333	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IAD21_04335	COG0483	inositol monophosphate 1-phosphatase activity
IAD21_04337	COG0736	holo-[acyl-carrier-protein] synthase activity
IAD21_04338	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_04341	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAD21_04345	COG0330	HflC and HflK could
IAD21_04347	COG0251	oxidation-reduction process
IAD21_04359	COG1160	GTP binding
IAD21_04362	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IAD21_04364	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IAD21_04365	COG0776	regulation of translation
IAD21_04369	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IAD21_04374	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IAD21_04388	COG0556	nucleotide-excision repair
IAD21_04393	COG1609	Transcriptional regulator
IAD21_04395	COG1609	Transcriptional regulator
IAD21_04396	COG3250	beta-galactosidase activity
IAD21_04403	COG2207	Transcriptional regulator
IAD21_04411	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAD21_04413	COG1063	alcohol dehydrogenase
IAD21_04417	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAD21_04419	COG1840	ABC-type Fe3 transport system, periplasmic component
IAD21_04425	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_04431	COG2165	general secretion pathway protein
IAD21_04438	COG5434	Belongs to the glycosyl hydrolase 28 family
IAD21_04460	COG2201	protein-glutamate methylesterase activity
IAD21_04462	COG0840	transmembrane signaling receptor activity
IAD21_04462	COG5278	phosphoserine phosphatase activity
IAD21_04470	COG0745	RESPONSE REGULATOR receiver
IAD21_04474	COG5001	Diguanylate cyclase
IAD21_04475	COG3250	beta-galactosidase activity
IAD21_04481	COG1609	Transcriptional regulator
IAD21_04483	COG3250	beta-galactosidase activity
IAD21_04485	COG0667	Aldo Keto reductase
IAD21_04495	COG4249	Peptidase C14 caspase catalytic subunit p20
IAD21_04495	COG2319	Wd-40 repeat
IAD21_04504	COG0667	Aldo Keto reductase
IAD21_04510	COG1472	Belongs to the glycosyl hydrolase 3 family
IAD21_04512	COG1054	Belongs to the UPF0176 family
IAD21_04513	COG3119	arylsulfatase activity
IAD21_04525	COG3250	beta-galactosidase activity
IAD21_04531	COG2226	methyltransferase
IAD21_04532	COG0784	Response regulator, receiver
IAD21_04532	COG2205	protein histidine kinase activity
IAD21_04536	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IAD21_04537	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IAD21_04542	COG3940	Belongs to the glycosyl hydrolase 43 family
IAD21_04545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAD21_04545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAD21_04550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAD21_04551	COG1312	Catalyzes the dehydration of D-mannonate
IAD21_04552	COG1063	alcohol dehydrogenase
IAD21_04553	COG0156	8-amino-7-oxononanoate synthase activity
IAD21_04554	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IAD21_04559	COG2200	EAL domain
IAD21_04570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAD21_04572	COG0534	Mate efflux family protein
IAD21_04573	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IAD21_04575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAD21_04575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAD21_04575	COG3321	synthase
IAD21_04575	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IAD21_04581	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_04585	COG3119	arylsulfatase activity
IAD21_04593	COG1609	Transcriptional regulator
IAD21_04594	COG3119	arylsulfatase activity
IAD21_04607	COG1132	(ABC) transporter
IAD21_04609	COG2186	Transcriptional regulator
IAD21_04613	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAD21_04617	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_04639	COG5002	protein histidine kinase activity
IAD21_04643	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IAD21_04644	COG0107	imidazoleglycerol-phosphate synthase activity
IAD21_04646	COG2720	vancomycin resistance protein
IAD21_04651	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IAD21_04655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IAD21_04657	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAD21_04659	COG0149	triose-phosphate isomerase activity
IAD21_04660	COG0670	Belongs to the BI1 family
IAD21_04661	COG0126	phosphoglycerate kinase activity
IAD21_04676	COG3250	beta-galactosidase activity
IAD21_04677	COG3250	beta-galactosidase activity
IAD21_04681	COG0521	Mo-molybdopterin cofactor biosynthetic process
IAD21_04685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IAD21_04694	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAD21_04695	COG5001	Diguanylate cyclase
IAD21_04698	COG0673	inositol 2-dehydrogenase activity
IAD21_04704	COG0051	transcription antitermination factor activity, RNA binding
IAD21_04705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IAD21_04706	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAD21_04708	COG0088	Forms part of the polypeptide exit tunnel
IAD21_04709	COG0089	rRNA binding
IAD21_04710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IAD21_04711	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IAD21_04712	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IAD21_04713	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IAD21_04714	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IAD21_04715	COG0255	Belongs to the universal ribosomal protein uL29 family
IAD21_04716	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IAD21_04717	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IAD21_04718	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IAD21_04719	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IAD21_04721	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAD21_04723	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IAD21_04725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IAD21_04726	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IAD21_04727	COG0200	Binds to the 23S rRNA
IAD21_04730	COG1501	Belongs to the glycosyl hydrolase 31 family
IAD21_04732	COG0848	biopolymer transport protein
IAD21_04734	COG0201	protein transport
IAD21_04736	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_04739	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IAD21_04740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IAD21_04741	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IAD21_04742	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IAD21_04743	COG0202	RNA polymerase activity
IAD21_04745	COG0101	tRNA pseudouridine synthase activity
IAD21_04746	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IAD21_04758	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IAD21_04761	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAD21_04763	COG4106	trans-aconitate 2-methyltransferase activity
IAD21_04766	COG4796	Type ii and iii secretion system protein
IAD21_04770	COG4948	Mandelate Racemase Muconate Lactonizing
IAD21_04772	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAD21_04773	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAD21_04777	COG0667	Aldo Keto reductase
IAD21_04778	COG1643	Atp-dependent helicase
IAD21_04780	COG4989	oxidoreductase activity
IAD21_04782	COG2514	catechol 2,3-dioxygenase activity
IAD21_04783	COG0022	dehydrogenase e1 component
IAD21_04794	COG2084	Dehydrogenase
IAD21_04798	COG2720	vancomycin resistance protein
IAD21_04800	COG2815	serine threonine protein kinase
IAD21_04800	COG0515	serine threonine protein kinase
IAD21_04802	COG0515	serine threonine protein kinase
IAD21_04802	COG2815	serine threonine protein kinase
IAD21_04805	COG1609	Transcriptional regulator
IAD21_04809	COG1472	Belongs to the glycosyl hydrolase 3 family
IAD21_04810	COG2755	lipolytic protein G-D-S-L family
IAD21_04814	COG2723	6-phospho-beta-galactosidase activity
IAD21_04823	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_04824	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAD21_04825	COG0681	Belongs to the peptidase S26 family
IAD21_04828	COG0335	large ribosomal subunit rRNA binding
IAD21_04829	COG0336	Belongs to the RNA methyltransferase TrmD family
IAD21_04832	COG0730	response to heat
IAD21_04834	COG5002	protein histidine kinase activity
IAD21_04838	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IAD21_04840	COG0228	four-way junction DNA binding
IAD21_04844	COG4208	sulfate ABC transporter
IAD21_04846	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IAD21_04847	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IAD21_04848	COG0745	RESPONSE REGULATOR receiver
IAD21_04849	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IAD21_04850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAD21_04858	COG1459	type II secretion system
IAD21_04868	COG0673	inositol 2-dehydrogenase activity
IAD21_04872	COG1609	Transcriptional regulator
IAD21_04885	COG2205	protein histidine kinase activity
IAD21_04886	COG2200	EAL domain
IAD21_04917	COG5002	protein histidine kinase activity
IAD21_04918	COG5002	protein histidine kinase activity
IAD21_04919	COG1610	YqeY-like protein
IAD21_04921	COG1702	phosphate starvation-inducible protein PhoH
IAD21_04922	COG2852	Protein conserved in bacteria
IAD21_04923	COG1480	7TM receptor with intracellular HD hydrolase
IAD21_04924	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IAD21_04936	COG0745	RESPONSE REGULATOR receiver
IAD21_04938	COG0306	phosphate transporter
IAD21_04939	COG0825	malonyl-CoA metabolic process
IAD21_04940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IAD21_04941	COG0077	Prephenate dehydratase
IAD21_04941	COG1605	Chorismate mutase
IAD21_04942	COG1335	isochorismatase
IAD21_04947	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IAD21_04949	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IAD21_04950	COG1758	RNA polymerase activity
IAD21_04951	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAD21_04962	COG0676	glucose-6-phosphate 1-epimerase activity
IAD21_04965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IAD21_04970	COG2813	Specifically methylates the guanine in position
IAD21_04972	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_04973	COG0463	Glycosyl transferase, family 2
IAD21_04974	COG1674	ftsk spoiiie
IAD21_04980	COG0488	(ABC) transporter
IAD21_04995	COG0542	response to heat
IAD21_04996	COG0542	response to heat
IAD21_04998	COG0052	Belongs to the universal ribosomal protein uS2 family
IAD21_05001	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IAD21_05002	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IAD21_05005	COG2815	serine threonine protein kinase
IAD21_05005	COG0515	serine threonine protein kinase
IAD21_05010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IAD21_05012	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAD21_05014	COG0567	Dehydrogenase, E1 component
IAD21_05020	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_05040	COG0745	RESPONSE REGULATOR receiver
IAD21_05041	COG5002	protein histidine kinase activity
IAD21_05042	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAD21_05043	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAD21_05049	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAD21_05050	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_05054	COG2755	lipolytic protein G-D-S-L family
IAD21_05054	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAD21_05058	COG3629	intracellular signal transduction
IAD21_05058	COG3903	Transcriptional regulator
IAD21_05070	COG1295	ribonuclease BN
IAD21_05071	COG0747	negative chemotaxis
IAD21_05074	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAD21_05074	COG0072	phenylalanine-tRNA ligase activity
IAD21_05075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IAD21_05078	COG2094	Belongs to the DNA glycosylase MPG family
IAD21_05080	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IAD21_05083	COG5001	Diguanylate cyclase
IAD21_05083	COG3300	MHYT domain
IAD21_05085	COG2146	nitrite reductase [NAD(P)H] activity
IAD21_05085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAD21_05087	COG0569	domain protein
IAD21_05088	COG0531	amino acid
IAD21_05092	COG0515	serine threonine protein kinase
IAD21_05092	COG2815	serine threonine protein kinase
IAD21_05093	COG0631	protein serine/threonine phosphatase activity
IAD21_05095	COG2304	oxidoreductase activity
IAD21_05103	COG0673	inositol 2-dehydrogenase activity
IAD21_05104	COG0667	Aldo Keto reductase
IAD21_05105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IAD21_05108	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_05109	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IAD21_05119	COG0823	Involved in the tonB-independent uptake of proteins
IAD21_05127	COG1185	polyribonucleotide nucleotidyltransferase activity
IAD21_05129	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IAD21_05135	COG0436	Aminotransferase
IAD21_05141	COG3422	double-strand break repair
IAD21_05142	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IAD21_05144	COG2814	Major facilitator Superfamily
IAD21_05145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAD21_05149	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IAD21_05154	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IAD21_05156	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IAD21_05162	COG0463	Glycosyl transferase, family 2
IAD21_05164	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IAD21_05174	COG0601	transmembrane transport
IAD21_05175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAD21_05177	COG0747	negative chemotaxis
IAD21_05179	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAD21_05180	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IAD21_05191	COG3119	arylsulfatase activity
IAD21_05192	COG5002	protein histidine kinase activity
IAD21_05193	COG0673	inositol 2-dehydrogenase activity
IAD21_05194	COG2706	6-phosphogluconolactonase activity
IAD21_05198	COG3345	alpha-galactosidase
IAD21_05200	COG3408	Glycogen debranching enzyme
IAD21_05200	COG3119	arylsulfatase activity
IAD21_05214	COG0481	GTPase activity
IAD21_05218	COG1597	lipid kinase activity
IAD21_05218	COG1803	Methylglyoxal synthase
IAD21_05219	COG1606	tRNA processing
IAD21_05228	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAD21_05230	COG0628	permease
IAD21_05232	COG1764	response to oxidative stress
IAD21_05233	COG1490	D-aminoacyl-tRNA deacylase activity
IAD21_05236	COG2207	Transcriptional regulator
IAD21_05236	COG1917	Cupin 2, conserved barrel domain protein
IAD21_05240	COG3386	PFAM SMP-30 Gluconolaconase
IAD21_05242	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IAD21_05247	COG1082	Xylose isomerase domain protein TIM barrel
IAD21_05266	COG1193	negative regulation of DNA recombination
IAD21_05277	COG0746	molybdenum cofactor guanylyltransferase activity
IAD21_05278	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IAD21_05279	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAD21_05280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IAD21_05281	COG2080	2 iron, 2 sulfur cluster binding
IAD21_05290	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_05293	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IAD21_05295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAD21_05300	COG0714	Associated with various cellular activities
IAD21_05301	COG0237	dephospho-CoA kinase activity
IAD21_05306	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IAD21_05307	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IAD21_05310	COG2267	carboxylic ester hydrolase activity
IAD21_05313	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_05315	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_05317	COG1459	type II secretion system
IAD21_05320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IAD21_05323	COG0511	ligase activity, forming carbon-carbon bonds
IAD21_05325	COG0439	Biotin carboxylase
IAD21_05326	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAD21_05332	COG0438	transferase activity, transferring glycosyl groups
IAD21_05335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAD21_05337	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAD21_05338	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IAD21_05345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAD21_05350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IAD21_05351	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAD21_05355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IAD21_05357	COG0137	argininosuccinate synthase activity
IAD21_05363	COG0346	lactoylglutathione lyase activity
IAD21_05364	COG0400	carboxylic ester hydrolase activity
IAD21_05366	COG0515	serine threonine protein kinase
IAD21_05374	COG1609	Transcriptional regulator
IAD21_05374	COG2207	Transcriptional regulator
IAD21_05376	COG3119	arylsulfatase activity
IAD21_05377	COG3119	arylsulfatase activity
IAD21_05390	COG1501	Belongs to the glycosyl hydrolase 31 family
IAD21_05391	COG2755	lipolytic protein G-D-S-L family
IAD21_05393	COG2382	esterase
IAD21_05395	COG4948	Mandelate Racemase Muconate Lactonizing
IAD21_05404	COG1609	Transcriptional regulator
IAD21_05406	COG1349	DNA-binding transcription factor activity
IAD21_05409	COG1621	beta-fructofuranosidase activity
IAD21_05411	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAD21_05415	COG3385	transposase activity
IAD21_05419	COG4977	sequence-specific DNA binding
IAD21_05421	COG3250	beta-galactosidase activity
IAD21_05423	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_05424	COG3250	beta-galactosidase activity
IAD21_05429	COG1022	Amp-dependent synthetase and ligase
IAD21_05434	COG0792	nuclease activity
IAD21_05435	COG0606	chelatase, subunit chli
IAD21_05441	COG3250	beta-galactosidase activity
IAD21_05443	COG3335	DDE superfamily endonuclease
IAD21_05447	COG5002	protein histidine kinase activity
IAD21_05459	COG5433	transposase activity
IAD21_05467	COG1609	Transcriptional regulator
IAD21_05474	COG0372	Belongs to the citrate synthase family
IAD21_05478	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IAD21_05484	COG5001	Diguanylate cyclase
IAD21_05486	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_05489	COG2205	protein histidine kinase activity
IAD21_05489	COG0784	Response regulator, receiver
IAD21_05490	COG1301	dicarboxylic acid transport
IAD21_05495	COG3940	Belongs to the glycosyl hydrolase 43 family
IAD21_05496	COG1695	Transcriptional regulator
IAD21_05503	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IAD21_05513	COG0745	RESPONSE REGULATOR receiver
IAD21_05514	COG2205	protein histidine kinase activity
IAD21_05515	COG3345	alpha-galactosidase
IAD21_05516	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_05521	COG1904	glucuronate isomerase
IAD21_05524	COG0667	Aldo Keto reductase
IAD21_05527	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAD21_05529	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAD21_05530	COG0135	phosphoribosylanthranilate isomerase activity
IAD21_05531	COG4232	protein-disulfide reductase activity
IAD21_05532	COG0193	aminoacyl-tRNA hydrolase activity
IAD21_05537	COG3250	beta-galactosidase activity
IAD21_05541	COG3250	beta-galactosidase activity
IAD21_05542	COG0673	inositol 2-dehydrogenase activity
IAD21_05543	COG2755	lipolytic protein G-D-S-L family
IAD21_05546	COG1252	NADH dehydrogenase
IAD21_05550	COG1595	DNA-templated transcription, initiation
IAD21_05555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAD21_05563	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_05565	COG2205	protein histidine kinase activity
IAD21_05567	COG5433	transposase activity
IAD21_05568	COG0793	Belongs to the peptidase S41A family
IAD21_05568	COG4946	Tricorn protease homolog
IAD21_05571	COG3876	Protein conserved in bacteria
IAD21_05574	COG0667	Aldo Keto reductase
IAD21_05576	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IAD21_05577	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_05579	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAD21_05585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IAD21_05585	COG1918	ferrous iron import across plasma membrane
IAD21_05587	COG1918	ferrous iron import across plasma membrane
IAD21_05587	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IAD21_05592	COG4589	Belongs to the CDS family
IAD21_05599	COG0095	Lipoate-protein ligase
IAD21_05600	COG0745	RESPONSE REGULATOR receiver
IAD21_05602	COG1595	DNA-templated transcription, initiation
IAD21_05607	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IAD21_05611	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAD21_05612	COG0386	Belongs to the glutathione peroxidase family
IAD21_05614	COG2081	HI0933 family
IAD21_05628	COG2124	cytochrome p450
IAD21_05631	COG0716	FMN binding
IAD21_05633	COG0778	Nitroreductase
IAD21_05637	COG0716	FMN binding
IAD21_05639	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IAD21_05643	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IAD21_05645	COG1609	Transcriptional regulator
IAD21_05650	COG1609	Transcriptional regulator
IAD21_05652	COG0657	acetylesterase activity
IAD21_05657	COG1725	Transcriptional regulator
IAD21_05661	COG0673	inositol 2-dehydrogenase activity
IAD21_05665	COG0363	glucosamine-6-phosphate deaminase activity
IAD21_05666	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IAD21_05667	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IAD21_05670	COG1012	belongs to the aldehyde dehydrogenase family
IAD21_05672	COG0667	Aldo Keto reductase
IAD21_05673	COG3263	regulation of cellular component size
IAD21_05674	COG0475	glutathione-regulated potassium exporter activity
IAD21_05677	COG0142	geranyltranstransferase activity
IAD21_05678	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IAD21_05683	COG3437	response regulator, receiver
IAD21_05684	COG0105	UTP biosynthetic process
IAD21_05685	COG1131	(ABC) transporter
IAD21_05687	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAD21_05690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IAD21_05695	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
IAD21_05696	COG5433	transposase activity
IAD21_05698	COG2204	response regulator
IAD21_05700	COG5002	protein histidine kinase activity
IAD21_05701	COG0531	amino acid
IAD21_05703	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IAD21_05704	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IAD21_05708	COG1175	transmembrane transport
IAD21_05716	COG3250	beta-galactosidase activity
IAD21_05721	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAD21_05725	COG0343	queuine tRNA-ribosyltransferase activity
IAD21_05727	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IAD21_05734	COG0129	dihydroxy-acid dehydratase activity
IAD21_05740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAD21_05743	COG2046	Belongs to the sulfate adenylyltransferase family
IAD21_05745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IAD21_05746	COG0357	Ribosomal RNA small subunit methyltransferase G
IAD21_05749	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IAD21_05755	COG0250	Participates in transcription elongation, termination and antitermination
IAD21_05756	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IAD21_05757	COG0081	regulation of translation
IAD21_05758	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IAD21_05759	COG0222	ribosome binding
IAD21_05767	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IAD21_05773	COG0667	Aldo Keto reductase
IAD21_05774	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IAD21_05775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IAD21_05776	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IAD21_05777	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IAD21_05778	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IAD21_05784	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAD21_05786	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IAD21_05787	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IAD21_05788	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IAD21_05791	COG0493	'glutamate synthase
IAD21_05793	COG1953	Uracil, thiamine, allantoin
IAD21_05795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAD21_05796	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IAD21_05798	COG2351	hydroxyisourate hydrolase activity
IAD21_05800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAD21_05801	COG2072	flavoprotein involved in K transport
IAD21_05802	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAD21_05805	COG0590	tRNA wobble adenosine to inosine editing
IAD21_05807	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAD21_05809	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAD21_05810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IAD21_05811	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IAD21_05812	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAD21_05814	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAD21_05815	COG3250	beta-galactosidase activity
IAD21_05816	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IAD21_05818	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IAD21_05818	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IAD21_05821	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IAD21_05827	COG0534	Mate efflux family protein
IAD21_05833	COG1129	ABC transporter
IAD21_05840	COG1609	Transcriptional regulator
IAD21_05844	COG3401	FG-GAP repeat protein
IAD21_05847	COG2755	lipolytic protein G-D-S-L family
IAD21_05854	COG2197	response regulator
IAD21_05859	COG0827	DNA restriction-modification system
IAD21_05860	COG0827	DNA restriction-modification system
IAD21_05861	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IAD21_05862	COG1733	regulation of RNA biosynthetic process
IAD21_05868	COG4149	molybdate abc transporter
IAD21_05869	COG0725	ABC transporter, periplasmic molybdate-binding protein
IAD21_05874	COG0848	biopolymer transport protein
IAD21_05875	COG0811	peptide transport
IAD21_05877	COG1505	serine-type exopeptidase activity
IAD21_05881	COG1132	(ABC) transporter
IAD21_05885	COG3940	Belongs to the glycosyl hydrolase 43 family
IAD21_05889	COG1028	Short-chain dehydrogenase reductase Sdr
IAD21_05891	COG3345	alpha-galactosidase
IAD21_05893	COG3345	alpha-galactosidase
IAD21_05898	COG2814	Major facilitator Superfamily
IAD21_05905	COG2205	protein histidine kinase activity
IAD21_05906	COG5002	protein histidine kinase activity
IAD21_05906	COG0784	Response regulator, receiver
IAD21_05906	COG2205	protein histidine kinase activity
IAD21_05916	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAD21_05928	COG1560	Kdo2-lipid A biosynthetic process
IAD21_05930	COG1663	tetraacyldisaccharide 4'-kinase activity
IAD21_05933	COG1132	(ABC) transporter
IAD21_05936	COG1472	Belongs to the glycosyl hydrolase 3 family
IAD21_05938	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IAD21_05939	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IAD21_05941	COG0473	3-isopropylmalate dehydrogenase activity
IAD21_05945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IAD21_05948	COG0756	dUTP diphosphatase activity
IAD21_05950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAD21_05951	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAD21_05954	COG0805	protein transport
IAD21_05955	COG1194	a g-specific adenine glycosylase
IAD21_05962	COG0509	glycine decarboxylation via glycine cleavage system
IAD21_05964	COG1774	PSP1 C-terminal conserved region
IAD21_05966	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAD21_05966	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAD21_05977	COG0791	NLP P60 protein
IAD21_05979	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IAD21_05980	COG0085	RNA polymerase activity
IAD21_05982	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IAD21_05983	COG2755	lipolytic protein G-D-S-L family
IAD21_05983	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAD21_05985	COG4974	Belongs to the 'phage' integrase family
IAD21_05988	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAD21_05997	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IAD21_06003	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IAD21_06005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IAD21_06006	COG2720	vancomycin resistance protein
IAD21_06037	COG3547	Transposase (IS116 IS110 IS902 family)
IAD21_06047	COG0542	response to heat
IAD21_06062	COG0326	Molecular chaperone. Has ATPase activity
IAD21_06070	COG1640	4-alpha-glucanotransferase
IAD21_06075	COG1609	Transcriptional regulator
IAD21_06075	COG2207	Transcriptional regulator
IAD21_06077	COG1063	alcohol dehydrogenase
IAD21_06083	COG2211	Major facilitator Superfamily
IAD21_06087	COG1609	Transcriptional regulator
IAD21_06096	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IAD21_06099	COG2895	sulfate adenylyltransferase (ATP) activity
IAD21_06101	COG0175	sulfate reduction
IAD21_06104	COG0351	phosphomethylpyrimidine kinase
IAD21_06104	COG0352	thiamine-phosphate diphosphorylase activity
IAD21_06105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAD21_06105	COG2022	thiamine diphosphate biosynthetic process
IAD21_06106	COG2022	thiamine diphosphate biosynthetic process
IAD21_06108	COG0352	thiamine-phosphate diphosphorylase activity
IAD21_06109	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IAD21_06110	COG3119	arylsulfatase activity
IAD21_06110	COG3408	Glycogen debranching enzyme
IAD21_06111	COG0277	FAD linked oxidase domain protein
IAD21_06113	COG0456	acetyltransferase
IAD21_06131	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IAD21_06141	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAD21_06150	COG2319	Wd-40 repeat
IAD21_06150	COG4249	Peptidase C14 caspase catalytic subunit p20
IAD21_06156	COG2208	phosphoserine phosphatase activity
IAD21_06160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAD21_06162	COG3458	cephalosporin-C deacetylase activity
IAD21_06165	COG4221	oxidoreductase activity
IAD21_06166	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IAD21_06173	COG4974	Belongs to the 'phage' integrase family
IAD21_06175	COG2255	four-way junction helicase activity
IAD21_06175	COG2255	four-way junction helicase activity
IAD21_06178	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IAD21_06181	COG0242	peptide deformylase activity
IAD21_06182	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAD21_06184	COG0681	Belongs to the peptidase S26 family
IAD21_06189	COG0297	glycogen (starch) synthase activity
IAD21_06196	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IAD21_06197	COG1792	Involved in formation and maintenance of cell shape
IAD21_06198	COG1077	Cell shape determining protein MreB Mrl
IAD21_06199	COG0424	maF-like protein
IAD21_06215	COG2234	aminopeptidase activity
IAD21_06217	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IAD21_06218	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAD21_06221	COG1215	transferase activity, transferring glycosyl groups
IAD21_06225	COG1621	beta-fructofuranosidase activity
IAD21_06227	COG0745	RESPONSE REGULATOR receiver
IAD21_06230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IAD21_06232	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAD21_06233	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IAD21_06234	COG4232	protein-disulfide reductase activity
IAD21_06240	COG1662	PFAM IS1 transposase
IAD21_06253	COG0719	Fe-S assembly protein
IAD21_06255	COG0396	ATPase activity
IAD21_06256	COG0719	Fe-S assembly protein
IAD21_06258	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAD21_06262	COG0066	3-isopropylmalate dehydratase activity
IAD21_06266	COG4968	Prepilin-type N-terminal cleavage methylation domain
IAD21_06269	COG3534	alpha-L-arabinofuranosidase
IAD21_06270	COG3507	Belongs to the glycosyl hydrolase 43 family
IAD21_06276	COG0612	Peptidase, M16
IAD21_06280	COG1216	Glycosyl transferase, family 2
IAD21_06281	COG0438	transferase activity, transferring glycosyl groups
IAD21_06282	COG1216	Glycosyl transferase, family 2
IAD21_06286	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IAD21_06291	COG2165	general secretion pathway protein
IAD21_06307	COG1609	Transcriptional regulator
IAD21_06312	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IAD21_06314	COG1609	Transcriptional regulator
IAD21_06315	COG0667	Aldo Keto reductase
IAD21_06316	COG1091	dTDP-4-dehydrorhamnose reductase activity
IAD21_06317	COG0667	Aldo Keto reductase
IAD21_06334	COG0069	glutamate synthase activity
IAD21_06338	COG0501	Belongs to the peptidase M48B family
IAD21_06347	COG1609	Transcriptional regulator
IAD21_06350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAD21_06352	COG0823	Involved in the tonB-independent uptake of proteins
IAD21_06353	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAD21_06367	COG1874	Beta-galactosidase
IAD21_06368	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAD21_06368	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAD21_06370	COG1216	Glycosyl transferase, family 2
IAD21_06371	COG0297	glycogen (starch) synthase activity
IAD21_06374	COG0297	glycogen (starch) synthase activity
IAD21_06387	COG5433	transposase activity
IAD21_06405	COG2801	Transposase and inactivated derivatives
IAD21_06413	COG1672	PFAM Archaeal ATPase
IAD21_06413	COG2319	Wd-40 repeat
IAD21_06416	COG4974	Belongs to the 'phage' integrase family
IAD21_06439	COG1192	Involved in chromosome partitioning
IAD21_06444	COG0587	DNA-directed DNA polymerase activity
IAD21_06448	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IAD21_06454	COG4804	nuclease activity
IAD21_06464	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released