locus-tag	class	description
CVPH_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVPH_0002	COG0592	DNA-directed DNA polymerase activity
CVPH_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVPH_0004	COG0187	DNA topoisomerase II activity
CVPH_0005	COG3954	Phosphoribulokinase
CVPH_0008	COG0495	leucyl-tRNA aminoacylation
CVPH_0009	COG0167	dihydroorotate dehydrogenase activity
CVPH_0010	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVPH_0012	COG0625	glutathione transferase activity
CVPH_0013	COG2857	Cytochrome c1
CVPH_0014	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CVPH_0015	COG0723	plastoquinol--plastocyanin reductase activity
CVPH_0017	COG0653	protein targeting
CVPH_0018	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CVPH_0019	COG0418	dihydroorotase activity
CVPH_0021	COG0196	riboflavin kinase activity
CVPH_0022	COG1194	a g-specific adenine glycosylase
CVPH_0023	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CVPH_0025	COG0436	Aminotransferase
CVPH_0028	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVPH_0031	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVPH_0032	COG0575	Belongs to the CDS family
CVPH_0033	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVPH_0034	COG0107	imidazoleglycerol-phosphate synthase activity
CVPH_0036	COG0109	protoheme IX farnesyltransferase activity
CVPH_0038	COG1999	signal sequence binding
CVPH_0041	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVPH_0042	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVPH_0047	COG3278	Belongs to the heme-copper respiratory oxidase family
CVPH_0050	COG2010	Cytochrome c
CVPH_0056	COG1007	ATP synthesis coupled electron transport
CVPH_0060	COG0713	ATP synthesis coupled electron transport
CVPH_0062	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVPH_0063	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVPH_0064	COG1034	ATP synthesis coupled electron transport
CVPH_0065	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CVPH_0067	COG0649	NAD binding
CVPH_0068	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVPH_0069	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVPH_0070	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVPH_0071	COG0312	modulator of DNA gyrase
CVPH_0077	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVPH_0078	COG0543	2 iron, 2 sulfur cluster binding
CVPH_0079	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVPH_0099	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVPH_0104	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVPH_0108	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVPH_0109	COG0740	serine-type endopeptidase activity
CVPH_0110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVPH_0111	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVPH_0112	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVPH_0115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVPH_0116	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVPH_0127	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVPH_0128	COG0470	DNA polymerase III
CVPH_0129	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVPH_0132	COG2210	Belongs to the sulfur carrier protein TusA family
CVPH_0133	COG0425	Belongs to the sulfur carrier protein TusA family
CVPH_0134	COG4783	chaperone-mediated protein folding
CVPH_0135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CVPH_0136	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVPH_0137	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVPH_0148	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVPH_0155	COG2226	methyltransferase
CVPH_0157	COG0500	methyltransferase
CVPH_0159	COG0233	cytoplasmic translational termination
CVPH_0160	COG0528	UMP kinase activity
CVPH_0161	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVPH_0163	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CVPH_0164	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVPH_0165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVPH_0166	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVPH_0168	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVPH_0168	COG1648	precorrin-2 dehydrogenase activity
CVPH_0170	COG0560	Phosphoserine phosphatase
CVPH_0171	COG1138	Cytochrome C-type biogenesis protein
CVPH_0173	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVPH_0174	COG0336	Belongs to the RNA methyltransferase TrmD family
CVPH_0205	COG0347	Belongs to the P(II) protein family
CVPH_0206	COG0004	ammonium transporteR
CVPH_0207	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVPH_0208	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CVPH_0209	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVPH_0210	COG0347	Belongs to the P(II) protein family
CVPH_0213	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CVPH_0214	COG3707	response regulator
CVPH_0216	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVPH_0217	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVPH_0218	COG0140	phosphoribosyl-ATP diphosphatase activity
CVPH_0219	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CVPH_0223	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVPH_0229	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CVPH_0230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVPH_0231	COG1560	Kdo2-lipid A biosynthetic process
CVPH_0232	COG0358	DNA primase activity
CVPH_0235	COG0275	rRNA processing
CVPH_0236	COG2001	Belongs to the MraZ family
CVPH_0238	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVPH_0240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CVPH_0242	COG1469	GTP cyclohydrolase I activity
CVPH_0243	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVPH_0248	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVPH_0250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVPH_0258	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVPH_0262	COG1472	Belongs to the glycosyl hydrolase 3 family
CVPH_0274	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVPH_0276	COG0564	pseudouridine synthase activity
CVPH_0279	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVPH_0283	COG0354	folic acid binding
CVPH_0284	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVPH_0285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CVPH_0286	COG0180	Tryptophanyl-tRNA synthetase
CVPH_0288	COG1187	pseudouridine synthase activity
CVPH_0289	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVPH_0290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVPH_0292	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVPH_0293	COG0154	amidase activity
CVPH_0294	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVPH_0295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CVPH_0296	COG1994	Peptidase M50
CVPH_0297	COG0442	prolyl-tRNA aminoacylation
CVPH_0298	COG0688	phosphatidylethanolamine metabolic process
CVPH_0299	COG4536	flavin adenine dinucleotide binding
CVPH_0300	COG0148	phosphopyruvate hydratase activity
CVPH_0301	COG0484	heat shock protein binding
CVPH_0302	COG0443	Heat shock 70 kDa protein
CVPH_0303	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVPH_0304	COG0742	ribosomal rna small subunit methyltransferase
CVPH_0305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVPH_0307	COG5000	phosphorelay sensor kinase activity
CVPH_0309	COG0569	domain protein
CVPH_0310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVPH_0311	COG1199	ATP-dependent helicase activity
CVPH_0312	COG0142	geranyltranstransferase activity
CVPH_0313	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CVPH_0317	COG1331	Highly conserved protein containing a thioredoxin domain
CVPH_0320	COG0066	3-isopropylmalate dehydratase activity
CVPH_0321	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVPH_0322	COG0367	asparagine synthase
CVPH_0323	COG0328	RNA-DNA hybrid ribonuclease activity
CVPH_0329	COG2867	negative regulation of translational initiation
CVPH_0330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVPH_0332	COG0105	UTP biosynthetic process
CVPH_0333	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVPH_0335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CVPH_0337	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVPH_0338	COG0826	peptidase U32
CVPH_0339	COG2813	Specifically methylates the guanine in position
CVPH_0340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CVPH_0344	COG0047	phosphoribosylformylglycinamidine synthase activity
CVPH_0344	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVPH_0345	COG0217	transcriptional regulatory protein
CVPH_0346	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CVPH_0347	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVPH_0349	COG0024	Methionine aminopeptidase
CVPH_0350	COG0501	Belongs to the peptidase M48B family
CVPH_0351	COG1704	LemA family
CVPH_0356	COG1758	RNA polymerase activity
CVPH_0361	COG2176	DNA-directed DNA polymerase activity
CVPH_0362	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVPH_0365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVPH_0366	COG1519	Transferase
CVPH_0367	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVPH_0371	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVPH_0372	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CVPH_0373	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVPH_0374	COG0316	Belongs to the HesB IscA family
CVPH_0374	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CVPH_0376	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CVPH_0378	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVPH_0392	COG0436	Aminotransferase
CVPH_0394	COG0602	queuosine metabolic process
CVPH_0397	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVPH_0400	COG0284	orotidine-5'-phosphate decarboxylase activity
CVPH_0404	COG0259	pyridoxamine-phosphate oxidase activity
CVPH_0405	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVPH_0406	COG1530	ribonuclease E activity
CVPH_0407	COG1028	Short-chain dehydrogenase reductase Sdr
CVPH_0409	COG1968	undecaprenyl-diphosphatase activity
CVPH_0410	COG0671	phosphoesterase, PA-phosphatase related
CVPH_0411	COG0308	aminopeptidase N
CVPH_0412	COG1058	Belongs to the CinA family
CVPH_0412	COG1546	Belongs to the CinA family
CVPH_0417	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CVPH_0418	COG0028	Belongs to the TPP enzyme family
CVPH_0420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVPH_0421	COG1183	phosphatidylcholine synthase activity
CVPH_0422	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVPH_0425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVPH_0426	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVPH_0429	COG2239	Acts as a magnesium transporter
CVPH_0433	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVPH_0438	COG0697	spore germination
CVPH_0439	COG1185	polyribonucleotide nucleotidyltransferase activity
CVPH_0445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVPH_0448	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVPH_0452	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVPH_0454	COG2217	Heavy metal translocating P-type atpase
CVPH_0466	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVPH_0467	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVPH_0469	COG0359	binds to the 23S rRNA
CVPH_0470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVPH_0471	COG0360	Binds together with S18 to 16S ribosomal RNA
CVPH_0472	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVPH_0473	COG1214	PFAM Peptidase M22, glycoprotease
CVPH_0475	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CVPH_0476	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVPH_0477	COG0776	regulation of translation
CVPH_0501	COG0151	Belongs to the GarS family
CVPH_0522	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVPH_0528	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVPH_0530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CVPH_0531	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVPH_0532	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVPH_0533	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVPH_0534	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVPH_0536	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVPH_0537	COG0072	phenylalanine-tRNA ligase activity
CVPH_0538	COG0776	regulation of translation
CVPH_0543	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVPH_0544	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVPH_0548	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVPH_0549	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVPH_0552	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CVPH_0554	COG4206	TonB-dependent receptor
CVPH_0555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVPH_0556	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVPH_0558	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVPH_0559	COG0287	Prephenate dehydrogenase
CVPH_0560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVPH_0562	COG2920	part of a sulfur-relay system
CVPH_0563	COG0681	Belongs to the peptidase S26 family
CVPH_0564	COG1475	DNA binding
CVPH_0566	COG0793	Belongs to the peptidase S41A family
CVPH_0570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CVPH_0573	COG0571	ribonuclease III activity
CVPH_0574	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVPH_0576	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CVPH_0577	COG0736	holo-[acyl-carrier-protein] synthase activity
CVPH_0580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVPH_0581	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVPH_0582	COG0481	GTPase activity
CVPH_0585	COG4137	Cytochrome C assembly protein
CVPH_0586	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVPH_0588	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVPH_0589	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVPH_0590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVPH_0592	COG0322	excinuclease ABC activity
CVPH_0594	COG0488	(ABC) transporter
CVPH_0595	COG3088	subunit of a heme lyase
CVPH_0596	COG0432	Pfam Uncharacterised protein family UPF0047
CVPH_0597	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVPH_0599	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVPH_0601	COG0776	regulation of translation
CVPH_0604	COG2363	Small membrane protein
CVPH_0606	COG1162	GTPase activity
CVPH_0608	COG0501	Belongs to the peptidase M48B family
CVPH_0609	COG0527	aspartate kinase activity
CVPH_0612	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVPH_0619	COG1104	cysteine desulfurase activity
CVPH_0620	COG0822	iron-sulfur transferase activity
CVPH_0623	COG0443	Heat shock 70 kDa protein
CVPH_0628	COG0489	protein tyrosine kinase activity
CVPH_0629	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVPH_0630	COG0339	signal peptide processing
CVPH_0632	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVPH_0633	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVPH_0634	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVPH_0636	COG0459	protein refolding
CVPH_0637	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVPH_0638	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVPH_0639	COG0194	GDP metabolic process
CVPH_0640	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CVPH_0641	COG0728	peptidoglycan biosynthetic process
CVPH_0642	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVPH_0643	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVPH_0644	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVPH_0646	COG0750	zinc metalloprotease
CVPH_0648	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVPH_0649	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVPH_0650	COG2967	ApaG domain
CVPH_0652	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVPH_0655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVPH_0656	COG0321	lipoyl(octanoyl) transferase activity
CVPH_0657	COG2921	Belongs to the UPF0250 family
CVPH_0658	COG2255	four-way junction helicase activity
CVPH_0661	COG3864	Putative metallopeptidase domain
CVPH_0668	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVPH_0669	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVPH_0670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVPH_0671	COG0330	HflC and HflK could
CVPH_0672	COG0330	HflC and HflK could
CVPH_0673	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CVPH_0674	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVPH_0675	COG0557	exoribonuclease II activity
CVPH_0676	COG0129	dihydroxy-acid dehydratase activity
CVPH_0679	COG1984	allophanate hydrolase subunit 2
CVPH_0680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVPH_0684	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CVPH_0686	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVPH_0687	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVPH_0689	COG3621	Patatin-like phospholipase
CVPH_0690	COG0183	Belongs to the thiolase family
CVPH_0691	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVPH_0691	COG1024	Enoyl-CoA hydratase
CVPH_0692	COG1960	acyl-CoA dehydrogenase activity
CVPH_0694	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVPH_0701	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVPH_0701	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVPH_0709	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CVPH_0712	COG0823	Involved in the tonB-independent uptake of proteins
CVPH_0714	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVPH_0716	COG2814	Major facilitator Superfamily
CVPH_0717	COG0629	single-stranded DNA binding
CVPH_0718	COG0537	adenosine 5'-monophosphoramidase activity
CVPH_0727	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVPH_0728	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVPH_0732	COG0488	(ABC) transporter
CVPH_0733	COG0772	Belongs to the SEDS family
CVPH_0734	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVPH_0735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVPH_0736	COG0174	glutamine synthetase
CVPH_0738	COG0408	coproporphyrinogen oxidase activity
CVPH_0740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CVPH_0741	COG0326	Molecular chaperone. Has ATPase activity
CVPH_0745	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CVPH_0747	COG1028	Short-chain dehydrogenase reductase Sdr
CVPH_0753	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVPH_0754	COG0416	fatty acid biosynthetic process
CVPH_0755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVPH_0756	COG0142	geranyltranstransferase activity
CVPH_0757	COG1722	exodeoxyribonuclease VII activity
CVPH_0759	COG0617	tRNA 3'-terminal CCA addition
CVPH_0760	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVPH_0761	COG0795	lipopolysaccharide-transporting ATPase activity
CVPH_0763	COG3118	belongs to the thioredoxin family
CVPH_0765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVPH_0768	COG0772	Belongs to the SEDS family
CVPH_0769	COG2951	lytic endotransglycosylase activity
CVPH_0770	COG1686	Belongs to the peptidase S11 family
CVPH_0774	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVPH_0775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CVPH_0776	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVPH_0781	COG0517	IMP dehydrogenase activity
CVPH_0781	COG0516	GMP reductase activity
CVPH_0787	COG0124	histidyl-tRNA synthetase
CVPH_0788	COG2976	Protein conserved in bacteria
CVPH_0789	COG1160	GTP binding
CVPH_0791	COG0504	CTP synthase activity
CVPH_0794	COG1132	(ABC) transporter
CVPH_0795	COG1012	belongs to the aldehyde dehydrogenase family
CVPH_0810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVPH_0813	COG1278	Cold shock
CVPH_0817	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVPH_0822	COG0515	serine threonine protein kinase
CVPH_0822	COG2815	serine threonine protein kinase
CVPH_0823	COG2223	nitrite transmembrane transporter activity
CVPH_0824	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVPH_0825	COG0314	molybdopterin synthase activity
CVPH_0826	COG0746	molybdenum cofactor guanylyltransferase activity
CVPH_0827	COG0303	'Molybdopterin
CVPH_0828	COG0315	cyclic pyranopterin monophosphate synthase activity
CVPH_0829	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVPH_0830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CVPH_0840	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVPH_0844	COG1850	ribulose-bisphosphate carboxylase activity
CVPH_0848	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CVPH_0849	COG1177	transmembrane transport
CVPH_0851	COG3842	ATPase activity
CVPH_0852	COG2132	Multicopper oxidase
CVPH_0862	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVPH_0863	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVPH_0864	COG1393	Belongs to the ArsC family
CVPH_0867	COG1490	D-aminoacyl-tRNA deacylase activity
CVPH_0868	COG0751	glycine-tRNA ligase activity
CVPH_0873	COG0811	peptide transport
CVPH_0875	COG2255	four-way junction helicase activity
CVPH_0877	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVPH_0878	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVPH_0879	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVPH_0880	COG0735	belongs to the Fur family
CVPH_0881	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVPH_0883	COG4133	protoheme IX ABC transporter activity
CVPH_0884	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVPH_0885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CVPH_0886	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CVPH_0888	COG1238	metal cluster binding
CVPH_0890	COG0668	transmembrane transport
CVPH_0891	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVPH_0894	COG1702	phosphate starvation-inducible protein PhoH
CVPH_0895	COG0482	sulfurtransferase activity
CVPH_0896	COG2915	High frequency lysogenization protein hflD homolog
CVPH_0897	COG0268	Binds directly to 16S ribosomal RNA
CVPH_0899	COG1570	exodeoxyribonuclease VII activity
CVPH_0900	COG0739	heme binding
CVPH_0904	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVPH_0907	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CVPH_0908	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVPH_0910	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVPH_0913	COG1388	LysM domain
CVPH_0913	COG0741	lytic transglycosylase activity
CVPH_0914	COG0271	Belongs to the BolA IbaG family
CVPH_0915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVPH_0915	COG0543	2 iron, 2 sulfur cluster binding
CVPH_0916	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVPH_0925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVPH_0929	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVPH_0932	COG1981	membrane
CVPH_0936	COG0612	Peptidase, M16
CVPH_0937	COG0612	Peptidase, M16
CVPH_0938	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CVPH_0939	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVPH_0940	COG0552	protein localization to endoplasmic reticulum
CVPH_0945	COG2154	pterin-4-alpha-carbinolamine dehydratase
CVPH_0946	COG0181	hydroxymethylbilane synthase activity
CVPH_0948	COG0165	Argininosuccinate lyase
CVPH_0949	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVPH_0952	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CVPH_0953	COG0542	response to heat
CVPH_0956	COG4660	Part of a membrane complex involved in electron transport
CVPH_0958	COG2890	protein-(glutamine-N5) methyltransferase activity
CVPH_0962	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CVPH_0962	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CVPH_0963	COG1077	Cell shape determining protein MreB Mrl
CVPH_0964	COG1792	Involved in formation and maintenance of cell shape
CVPH_0966	COG0768	penicillin binding
CVPH_0967	COG0343	queuine tRNA-ribosyltransferase activity
CVPH_0968	COG5265	(ABC) transporter
CVPH_0971	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVPH_0972	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVPH_0972	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVPH_0973	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVPH_0975	COG0587	DNA-directed DNA polymerase activity
CVPH_0977	COG3258	Cytochrome c
CVPH_0982	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVPH_0983	COG0085	RNA polymerase activity
CVPH_0984	COG0222	ribosome binding
CVPH_0985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVPH_0986	COG0081	regulation of translation
CVPH_0987	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVPH_0990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVPH_0991	COG0281	malic enzyme
CVPH_0995	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVPH_0995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVPH_0996	COG0537	adenosine 5'-monophosphoramidase activity
CVPH_1005	COG0778	Nitroreductase
CVPH_1009	COG2081	HI0933 family
CVPH_1010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVPH_1013	COG2350	Protein conserved in bacteria
CVPH_1015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CVPH_1022	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CVPH_1023	COG0134	indole-3-glycerol-phosphate synthase activity
CVPH_1024	COG1765	OsmC-like protein
CVPH_1025	COG2022	thiamine diphosphate biosynthetic process
CVPH_1030	COG0156	8-amino-7-oxononanoate synthase activity
CVPH_1031	COG2267	carboxylic ester hydrolase activity
CVPH_1032	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVPH_1035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVPH_1036	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVPH_1037	COG2835	tetraacyldisaccharide 4'-kinase activity
CVPH_1038	COG1663	tetraacyldisaccharide 4'-kinase activity
CVPH_1040	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVPH_1041	COG1136	(ABC) transporter
CVPH_1046	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CVPH_1047	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CVPH_1050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVPH_1051	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CVPH_1056	COG0802	atpase or kinase
CVPH_1057	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVPH_1059	COG1797	cobyrinic acid a,c-diamide synthase activity
CVPH_1066	COG2920	part of a sulfur-relay system
CVPH_1068	COG2923	Belongs to the DsrF TusC family
CVPH_1069	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CVPH_1070	COG2221	Nitrite and sulphite reductase 4Fe-4S
CVPH_1071	COG2221	Nitrite and sulphite reductase 4Fe-4S
CVPH_1072	COG0493	'glutamate synthase
CVPH_1073	COG0335	large ribosomal subunit rRNA binding
CVPH_1074	COG4974	Belongs to the 'phage' integrase family
CVPH_1078	COG1213	nucleotidyl transferase
CVPH_1079	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVPH_1080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVPH_1081	COG2853	Lipoprotein
CVPH_1082	COG0505	Belongs to the CarA family
CVPH_1085	COG0482	sulfurtransferase activity
CVPH_1088	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVPH_1089	COG0009	L-threonylcarbamoyladenylate synthase
CVPH_1091	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVPH_1092	COG0166	Belongs to the GPI family
CVPH_1100	COG0438	transferase activity, transferring glycosyl groups
CVPH_1103	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVPH_1107	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CVPH_1108	COG0542	response to heat
CVPH_1109	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVPH_1110	COG0795	lipopolysaccharide-transporting ATPase activity
CVPH_1111	COG0519	Catalyzes the synthesis of GMP from XMP
CVPH_1111	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVPH_1114	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CVPH_1115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVPH_1116	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVPH_1117	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVPH_1118	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVPH_1119	COG0557	exoribonuclease II activity
CVPH_1120	COG0509	glycine decarboxylation via glycine cleavage system
CVPH_1125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVPH_1126	COG3161	chorismate lyase activity
CVPH_1127	COG2226	methyltransferase
CVPH_1128	COG0512	Glutamine amidotransferase of anthranilate synthase
CVPH_1129	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVPH_1130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVPH_1131	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVPH_1134	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVPH_1135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVPH_1138	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVPH_1143	COG0513	Belongs to the DEAD box helicase family
CVPH_1144	COG0659	secondary active sulfate transmembrane transporter activity
CVPH_1145	COG1278	Cold shock
CVPH_1151	COG2925	Exonuclease
CVPH_1152	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CVPH_1154	COG3001	Fructosamine kinase
CVPH_1155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVPH_1156	COG0131	Imidazoleglycerol-phosphate dehydratase
CVPH_1160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVPH_1161	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVPH_1162	COG0351	phosphomethylpyrimidine kinase
CVPH_1164	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVPH_1165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVPH_1166	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVPH_1169	COG0842	Transport permease protein
CVPH_1170	COG1131	(ABC) transporter
CVPH_1171	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVPH_1172	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVPH_1173	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVPH_1175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CVPH_1181	COG0513	Belongs to the DEAD box helicase family
CVPH_1182	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CVPH_1185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVPH_1186	COG0312	modulator of DNA gyrase
CVPH_1188	COG4535	Mg2 and Co2 transporter CorC
CVPH_1189	COG2914	Belongs to the UPF0125 (RnfH) family
CVPH_1190	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVPH_1192	COG0346	lactoylglutathione lyase activity
CVPH_1201	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVPH_1202	COG1137	ATPase activity
CVPH_1204	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CVPH_1204	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CVPH_1205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CVPH_1207	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVPH_1208	COG0583	DNA-binding transcription factor activity
CVPH_1209	COG0471	metal ion transport
CVPH_1209	COG3273	potassium ion transport
CVPH_1213	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVPH_1215	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVPH_1216	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVPH_1225	COG1610	YqeY-like protein
CVPH_1226	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVPH_1227	COG0203	ribosomal protein L17
CVPH_1228	COG0202	RNA polymerase activity
CVPH_1229	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVPH_1230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVPH_1231	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVPH_1232	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVPH_1234	COG0200	Binds to the 23S rRNA
CVPH_1235	COG1841	ribosomal large subunit assembly
CVPH_1236	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVPH_1237	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVPH_1238	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVPH_1239	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVPH_1240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVPH_1241	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVPH_1242	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVPH_1243	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVPH_1244	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVPH_1245	COG0255	Belongs to the universal ribosomal protein uL29 family
CVPH_1246	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVPH_1247	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVPH_1248	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVPH_1249	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVPH_1250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVPH_1251	COG0089	rRNA binding
CVPH_1252	COG0088	Forms part of the polypeptide exit tunnel
CVPH_1253	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVPH_1254	COG0051	transcription antitermination factor activity, RNA binding
CVPH_1255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVPH_1256	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVPH_1257	COG0049	tRNA binding
CVPH_1258	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVPH_1259	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVPH_1260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CVPH_1260	COG0517	IMP dehydrogenase activity
CVPH_1263	COG0737	Belongs to the 5'-nucleotidase family
CVPH_1267	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CVPH_1268	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVPH_1269	COG0137	argininosuccinate synthase activity
CVPH_1271	COG2983	Belongs to the UPF0260 family
CVPH_1273	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CVPH_1274	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVPH_1277	COG0045	succinate-CoA ligase (ADP-forming) activity
CVPH_1278	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CVPH_1283	COG4659	FMN binding
CVPH_1284	COG4658	electron transport chain
CVPH_1286	COG2878	Part of a membrane complex involved in electron transport
CVPH_1287	COG4657	Part of a membrane complex involved in electron transport
CVPH_1299	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVPH_1300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CVPH_1301	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVPH_1304	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVPH_1305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVPH_1307	COG0513	Belongs to the DEAD box helicase family
CVPH_1309	COG0306	phosphate transporter
CVPH_1310	COG1392	Phosphate transport regulator
CVPH_1312	COG0825	malonyl-CoA metabolic process
CVPH_1313	COG0037	tRNA processing
CVPH_1314	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVPH_1315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVPH_1317	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVPH_1318	COG0546	phosphoglycolate phosphatase activity
CVPH_1322	COG0006	proline dipeptidase activity
CVPH_1323	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVPH_1324	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CVPH_1325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVPH_1326	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVPH_1327	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVPH_1329	COG0157	Belongs to the NadC ModD family
CVPH_1330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVPH_1332	COG0019	diaminopimelate decarboxylase activity
CVPH_1337	COG0494	nUDIX hydrolase
CVPH_1357	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVPH_1358	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVPH_1359	COG0473	3-isopropylmalate dehydrogenase activity
CVPH_1360	COG1773	rubredoxin
CVPH_1361	COG0450	alkyl hydroperoxide reductase
CVPH_1362	COG0215	cysteine-tRNA ligase activity
CVPH_1372	COG0205	6-phosphofructokinase activity
CVPH_1373	COG0563	adenylate kinase activity
CVPH_1375	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CVPH_1377	COG1047	Peptidyl-prolyl cis-trans
CVPH_1382	COG2046	Belongs to the sulfate adenylyltransferase family
CVPH_1385	COG0352	thiamine-phosphate diphosphorylase activity
CVPH_1387	COG1074	ATP-dependent DNA helicase activity
CVPH_1388	COG0018	arginyl-trna synthetase
CVPH_1393	COG0348	domain, Protein
CVPH_1394	COG2171	N-acyltransferase activity
CVPH_1396	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CVPH_1398	COG0084	hydrolase, TatD family'
CVPH_1400	COG0357	Ribosomal RNA small subunit methyltransferase G
CVPH_1401	COG0445	tRNA wobble uridine modification
CVPH_1403	COG0469	pyruvate kinase activity
CVPH_1404	COG0126	phosphoglycerate kinase activity
CVPH_1406	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVPH_1407	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVPH_1408	COG0237	dephospho-CoA kinase activity
CVPH_1410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CVPH_1418	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVPH_1419	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVPH_1420	COG0195	Participates in both transcription termination and antitermination
CVPH_1421	COG0779	Required for maturation of 30S ribosomal subunits
CVPH_1422	COG0189	ligase activity
CVPH_1424	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CVPH_1425	COG1477	protein flavinylation
CVPH_1426	COG2951	lytic endotransglycosylase activity
CVPH_1428	COG0540	Belongs to the ATCase OTCase family
CVPH_1430	COG0492	ferredoxin-NADP+ reductase activity
CVPH_1431	COG1674	ftsk spoiiie
CVPH_1442	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVPH_1443	COG0708	Exodeoxyribonuclease III
CVPH_1444	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVPH_1445	COG3030	protein affecting phage T7 exclusion by the F plasmid
CVPH_1446	COG0285	dihydrofolate synthase activity
CVPH_1450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVPH_1452	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVPH_1453	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVPH_1454	COG1862	Preprotein translocase
CVPH_1455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVPH_1456	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVPH_1460	COG2197	response regulator
CVPH_1461	COG3850	Histidine kinase
CVPH_1462	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVPH_1463	COG2918	glutathione biosynthetic process
CVPH_1464	COG0352	thiamine-phosphate diphosphorylase activity
CVPH_1472	COG1040	competence protein
CVPH_1473	COG3022	response to hydroperoxide
CVPH_1474	COG0070	glutamate synthase
CVPH_1474	COG0069	glutamate synthase activity
CVPH_1474	COG0067	glutamate synthase
CVPH_1476	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CVPH_1478	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVPH_1479	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVPH_1480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVPH_1481	COG1047	Peptidyl-prolyl cis-trans
CVPH_1483	COG0159	tryptophan synthase activity
CVPH_1484	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVPH_1485	COG0254	rRNA binding
CVPH_1486	COG2217	Heavy metal translocating P-type atpase
CVPH_1488	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVPH_1494	COG0133	tryptophan synthase activity
CVPH_1495	COG0135	phosphoribosylanthranilate isomerase activity
CVPH_1504	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CVPH_1505	COG0594	ribonuclease P activity
CVPH_1506	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVPH_1507	COG0706	membrane insertase activity
CVPH_1508	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CVPH_1510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CVPH_1512	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVPH_1513	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVPH_1514	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVPH_1515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVPH_1516	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVPH_1517	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVPH_1519	COG0356	it plays a direct role in the translocation of protons across the membrane
CVPH_1521	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVPH_1523	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVPH_1524	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVPH_1541	COG4232	protein-disulfide reductase activity
CVPH_1542	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVPH_1543	COG0511	ligase activity, forming carbon-carbon bonds
CVPH_1544	COG0439	Biotin carboxylase
CVPH_1545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVPH_1546	COG0316	Belongs to the HesB IscA family
CVPH_1548	COG2226	methyltransferase
CVPH_1550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVPH_1551	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVPH_1552	COG0193	aminoacyl-tRNA hydrolase activity
CVPH_1553	COG0012	GTP binding
CVPH_1554	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CVPH_1555	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVPH_1558	COG0052	Belongs to the universal ribosomal protein uS2 family
CVPH_1559	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVPH_1573	COG0149	triose-phosphate isomerase activity