locus-tag	class	description
AM1_0011	COG0616	signal peptide processing
AM1_0013	COG0697	spore germination
AM1_0014	COG2233	PERMEase
AM1_0020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AM1_0024	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AM1_0024	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM1_0028	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM1_0029	COG2197	response regulator
AM1_0033	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AM1_0034	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM1_0036	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM1_0040	COG3659	wide pore channel activity
AM1_0044	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_0046	COG0802	atpase or kinase
AM1_0048	COG2203	Gaf domain
AM1_0048	COG0840	transmembrane signaling receptor activity
AM1_0049	COG0702	epimerase
AM1_0064	COG3328	transposase activity
AM1_0069	COG5001	Diguanylate cyclase
AM1_0069	COG4251	negative regulation of phosphorylation
AM1_0069	COG3706	GGDEF domain
AM1_0069	COG2203	Gaf domain
AM1_0070	COG0432	Pfam Uncharacterised protein family UPF0047
AM1_0071	COG1840	ABC-type Fe3 transport system, periplasmic component
AM1_0073	COG3264	Mechanosensitive ion channel
AM1_0073	COG1196	nuclear chromosome segregation
AM1_0079	COG0598	Magnesium transport protein CorA
AM1_0083	COG0705	Rhomboid family
AM1_0083	COG0457	Tetratricopeptide repeat
AM1_0085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM1_0102	COG3328	transposase activity
AM1_0109	COG3536	Protein conserved in bacteria
AM1_0110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM1_0112	COG0315	cyclic pyranopterin monophosphate synthase activity
AM1_0117	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM1_0119	COG1595	DNA-templated transcription, initiation
AM1_0124	COG5433	transposase activity
AM1_0131	COG0513	Belongs to the DEAD box helicase family
AM1_0132	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_0133	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_0134	COG1260	myo-inositol-1-phosphate synthase
AM1_0137	COG1131	(ABC) transporter
AM1_0146	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM1_0149	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AM1_0155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM1_0159	COG4638	Rieske (2fe-2S)
AM1_0162	COG0025	NhaP-type Na H and K H
AM1_0165	COG2319	Wd-40 repeat
AM1_0165	COG3903	Transcriptional regulator
AM1_0168	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM1_0169	COG0848	biopolymer transport protein
AM1_0171	COG0811	peptide transport
AM1_0172	COG3903	Transcriptional regulator
AM1_0172	COG2319	Wd-40 repeat
AM1_0175	COG0581	inorganic phosphate transmembrane transporter activity
AM1_0176	COG0573	inorganic phosphate transmembrane transporter activity
AM1_0177	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM1_0180	COG1943	Transposase
AM1_0183	COG1366	Belongs to the anti-sigma-factor antagonist family
AM1_0188	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM1_0197	COG0784	Response regulator, receiver
AM1_0197	COG5002	protein histidine kinase activity
AM1_0204	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_0210	COG0300	oxidoreductase activity
AM1_0212	COG1017	nitric oxide dioxygenase activity
AM1_0212	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM1_0214	COG2223	nitrite transmembrane transporter activity
AM1_0218	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM1_0220	COG2205	protein histidine kinase activity
AM1_0220	COG5002	protein histidine kinase activity
AM1_0220	COG0784	Response regulator, receiver
AM1_0224	COG2205	protein histidine kinase activity
AM1_0224	COG0745	RESPONSE REGULATOR receiver
AM1_0224	COG4191	Histidine kinase
AM1_0227	COG5001	Diguanylate cyclase
AM1_0227	COG1716	ATPase activity
AM1_0245	COG0582	viral genome integration into host DNA
AM1_0249	COG3608	succinylglutamate desuccinylase aspartoacylase
AM1_0249	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AM1_0255	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AM1_0263	COG1222	aaa ATPase
AM1_0267	COG2197	response regulator
AM1_0268	COG4191	Histidine kinase
AM1_0283	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AM1_0284	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM1_0285	COG2204	response regulator
AM1_0286	COG0784	Response regulator, receiver
AM1_0287	COG4251	negative regulation of phosphorylation
AM1_0314	COG0072	phenylalanine-tRNA ligase activity
AM1_0314	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM1_0319	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AM1_0329	COG1515	deoxyribonuclease V activity
AM1_0333	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM1_0339	COG0672	)-iron permease
AM1_0350	COG0175	sulfate reduction
AM1_0359	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM1_0362	COG0534	Mate efflux family protein
AM1_0365	COG2066	Belongs to the glutaminase family
AM1_0377	COG0438	transferase activity, transferring glycosyl groups
AM1_0380	COG0438	transferase activity, transferring glycosyl groups
AM1_0386	COG1132	(ABC) transporter
AM1_0387	COG0297	glycogen (starch) synthase activity
AM1_0394	COG0745	RESPONSE REGULATOR receiver
AM1_0395	COG5002	protein histidine kinase activity
AM1_0400	COG0653	protein targeting
AM1_0401	COG1960	acyl-CoA dehydrogenase activity
AM1_0402	COG0542	response to heat
AM1_0404	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AM1_0406	COG0529	Catalyzes the synthesis of activated sulfate
AM1_0408	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AM1_0409	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AM1_0412	COG0019	diaminopimelate decarboxylase activity
AM1_0413	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AM1_0414	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM1_0419	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM1_0422	COG0443	Heat shock 70 kDa protein
AM1_0423	COG0484	heat shock protein binding
AM1_0429	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM1_0437	COG1042	CoA-binding domain protein
AM1_0437	COG0045	succinate-CoA ligase (ADP-forming) activity
AM1_0437	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM1_0439	COG1882	Formate acetyltransferase
AM1_0440	COG0574	Belongs to the PEP-utilizing enzyme family
AM1_0440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM1_0441	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AM1_0442	COG1454	alcohol dehydrogenase
AM1_0442	COG1012	belongs to the aldehyde dehydrogenase family
AM1_0443	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AM1_0445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM1_0450	COG0723	plastoquinol--plastocyanin reductase activity
AM1_0452	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM1_0454	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_0465	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AM1_0466	COG5398	heme oxygenase
AM1_0467	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM1_0473	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AM1_0482	COG2346	COG2346, Truncated hemoglobins
AM1_0485	COG3335	DDE superfamily endonuclease
AM1_0498	COG1484	DNA-dependent DNA replication
AM1_0499	COG4584	PFAM Integrase catalytic
AM1_0510	COG0681	Belongs to the peptidase S26 family
AM1_0515	COG2197	response regulator
AM1_0516	COG4585	Histidine kinase
AM1_0518	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM1_0523	COG1834	amidinotransferase
AM1_0525	COG1191	sigma factor activity
AM1_0529	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM1_0532	COG4372	Transposase
AM1_0533	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AM1_0533	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AM1_0547	COG3706	GGDEF domain
AM1_0547	COG0745	RESPONSE REGULATOR receiver
AM1_0549	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AM1_0555	COG1192	Involved in chromosome partitioning
AM1_0556	COG0583	DNA-binding transcription factor activity
AM1_0560	COG0501	Belongs to the peptidase M48B family
AM1_0563	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AM1_0564	COG3706	GGDEF domain
AM1_0564	COG4251	negative regulation of phosphorylation
AM1_0564	COG2203	Gaf domain
AM1_0564	COG5001	Diguanylate cyclase
AM1_0568	COG0724	RNA recognition motif
AM1_0573	COG1309	transcriptional regulator
AM1_0574	COG0110	maltose O-acetyltransferase activity
AM1_0575	COG0438	transferase activity, transferring glycosyl groups
AM1_0582	COG5001	Diguanylate cyclase
AM1_0584	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AM1_0586	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AM1_0588	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AM1_0590	COG0483	inositol monophosphate 1-phosphatase activity
AM1_0593	COG3273	potassium ion transport
AM1_0593	COG0471	metal ion transport
AM1_0594	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM1_0595	COG0798	PFAM Bile acid sodium symporter
AM1_0596	COG0789	Transcriptional regulator
AM1_0598	COG0751	glycine-tRNA ligase activity
AM1_0599	COG0612	Peptidase, M16
AM1_0601	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM1_0602	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM1_0603	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM1_0604	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM1_0606	COG2124	cytochrome p450
AM1_0608	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM1_0608	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM1_0609	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AM1_0615	COG0408	coproporphyrinogen oxidase activity
AM1_0617	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AM1_0619	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM1_0620	COG0501	Belongs to the peptidase M48B family
AM1_0624	COG0739	heme binding
AM1_0625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AM1_0625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AM1_0632	COG0583	DNA-binding transcription factor activity
AM1_0633	COG1741	Belongs to the pirin family
AM1_0636	COG0589	response to stress
AM1_0637	COG0126	phosphoglycerate kinase activity
AM1_0642	COG0124	histidyl-tRNA synthetase
AM1_0646	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_0647	COG1136	(ABC) transporter
AM1_0647	COG0577	efflux transmembrane transporter activity
AM1_0648	COG1136	(ABC) transporter
AM1_0652	COG0416	fatty acid biosynthetic process
AM1_0653	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM1_0654	COG0697	spore germination
AM1_0655	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM1_0656	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM1_0658	COG0517	IMP dehydrogenase activity
AM1_0658	COG1125	glycine betaine transport
AM1_0661	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AM1_0664	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM1_0667	COG0484	heat shock protein binding
AM1_0668	COG1994	Peptidase M50
AM1_0671	COG0390	transport system, permease component
AM1_0672	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AM1_0683	COG1662	PFAM IS1 transposase
AM1_0686	COG1487	ribonuclease activity
AM1_0694	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM1_0695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM1_0696	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM1_0696	COG0022	dehydrogenase e1 component
AM1_0699	COG2226	methyltransferase
AM1_0701	COG0515	serine threonine protein kinase
AM1_0705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM1_0708	COG3328	transposase activity
AM1_0713	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM1_0714	COG3706	GGDEF domain
AM1_0714	COG5001	Diguanylate cyclase
AM1_0714	COG4251	negative regulation of phosphorylation
AM1_0714	COG2203	Gaf domain
AM1_0716	COG2319	Wd-40 repeat
AM1_0716	COG1672	PFAM Archaeal ATPase
AM1_0720	COG0318	PFAM AMP-dependent synthetase and ligase
AM1_0725	COG4221	oxidoreductase activity
AM1_0725	COG3321	synthase
AM1_0725	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_0725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM1_0726	COG0156	8-amino-7-oxononanoate synthase activity
AM1_0728	COG4221	oxidoreductase activity
AM1_0742	COG1662	PFAM IS1 transposase
AM1_0744	COG0587	DNA-directed DNA polymerase activity
AM1_0746	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM1_0747	COG0814	amino acid
AM1_0769	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AM1_0772	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM1_0773	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM1_0776	COG2363	Small membrane protein
AM1_0782	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM1_0791	COG0646	methionine synthase
AM1_0791	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM1_0798	COG0431	NADPH-dependent FMN reductase
AM1_0800	COG0438	transferase activity, transferring glycosyl groups
AM1_0806	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM1_0807	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM1_0809	COG1122	ATPase activity
AM1_0810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_0817	COG0753	catalase activity
AM1_0820	COG1309	transcriptional regulator
AM1_0822	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM1_0824	COG2124	cytochrome p450
AM1_0828	COG0745	RESPONSE REGULATOR receiver
AM1_0830	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AM1_0832	COG1672	PFAM Archaeal ATPase
AM1_0832	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AM1_0835	COG1233	COG1233 Phytoene dehydrogenase and related
AM1_0841	COG0612	Peptidase, M16
AM1_0843	COG3011	Protein conserved in bacteria
AM1_0847	COG0768	penicillin binding
AM1_0849	COG0275	rRNA processing
AM1_0850	COG5398	heme oxygenase
AM1_0855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AM1_0857	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AM1_0858	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM1_0863	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM1_0866	COG3659	wide pore channel activity
AM1_0867	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AM1_0868	COG0830	nickel cation binding
AM1_0875	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AM1_0876	COG0175	sulfate reduction
AM1_0884	COG2226	methyltransferase
AM1_0891	COG0356	it plays a direct role in the translocation of protons across the membrane
AM1_0894	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM1_0895	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AM1_0896	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AM1_0897	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM1_0899	COG4636	protein conserved in cyanobacteria
AM1_0904	COG0066	3-isopropylmalate dehydratase activity
AM1_0908	COG0784	Response regulator, receiver
AM1_0912	COG2203	Gaf domain
AM1_0912	COG0840	transmembrane signaling receptor activity
AM1_0913	COG2198	Histidine kinase
AM1_0913	COG0643	Histidine kinase
AM1_0913	COG0643	Histidine kinase
AM1_0913	COG2198	Histidine kinase
AM1_0917	COG0004	ammonium transporteR
AM1_0919	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AM1_0920	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM1_0925	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AM1_0926	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AM1_0930	COG0779	Required for maturation of 30S ribosomal subunits
AM1_0931	COG0195	Participates in both transcription termination and antitermination
AM1_0932	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AM1_0940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM1_0943	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM1_0950	COG0469	pyruvate kinase activity
AM1_0951	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM1_0955	COG2217	Heavy metal translocating P-type atpase
AM1_0958	COG2831	hemolysin activation secretion protein
AM1_0959	COG2205	protein histidine kinase activity
AM1_0963	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM1_0971	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_0975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_0981	COG0564	pseudouridine synthase activity
AM1_0986	COG1136	(ABC) transporter
AM1_0991	COG0463	Glycosyl transferase, family 2
AM1_0991	COG0457	Tetratricopeptide repeat
AM1_0992	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AM1_0993	COG4251	negative regulation of phosphorylation
AM1_0996	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AM1_1002	COG1045	serine acetyltransferase
AM1_1004	COG0590	tRNA wobble adenosine to inosine editing
AM1_1006	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AM1_1014	COG4597	amino acid ABC transporter
AM1_1015	COG0765	amino acid transport
AM1_1016	COG1126	abc transporter atp-binding protein
AM1_1019	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM1_1024	COG0438	transferase activity, transferring glycosyl groups
AM1_1025	COG0438	transferase activity, transferring glycosyl groups
AM1_1037	COG0495	leucyl-tRNA aminoacylation
AM1_1040	COG3657	addiction module killer protein
AM1_1041	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_1052	COG0583	DNA-binding transcription factor activity
AM1_1055	COG1672	PFAM Archaeal ATPase
AM1_1055	COG2319	Wd-40 repeat
AM1_1056	COG2203	Gaf domain
AM1_1056	COG3706	GGDEF domain
AM1_1056	COG4251	negative regulation of phosphorylation
AM1_1056	COG5001	Diguanylate cyclase
AM1_1059	COG0424	maF-like protein
AM1_1062	COG0024	Methionine aminopeptidase
AM1_1064	COG1968	undecaprenyl-diphosphatase activity
AM1_1068	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM1_1069	COG1799	cell septum assembly
AM1_1070	COG0277	FAD linked oxidase domain protein
AM1_1073	COG3239	Fatty acid desaturase
AM1_1078	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM1_1079	COG0456	acetyltransferase
AM1_1081	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM1_1087	COG0653	protein targeting
AM1_1088	COG2095	MarC family integral membrane protein
AM1_1092	COG1446	asparaginase
AM1_1093	COG2226	methyltransferase
AM1_1094	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AM1_1102	COG3541	Predicted nucleotidyltransferase
AM1_1104	COG0840	transmembrane signaling receptor activity
AM1_1108	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AM1_1110	COG1575	Belongs to the MenA family. Type 1 subfamily
AM1_1111	COG0484	heat shock protein binding
AM1_1113	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM1_1116	COG0322	excinuclease ABC activity
AM1_1118	COG0297	glycogen (starch) synthase activity
AM1_1121	COG1309	transcriptional regulator
AM1_1131	COG0735	belongs to the Fur family
AM1_1139	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AM1_1142	COG1420	regulation of RNA biosynthetic process
AM1_1150	COG0501	Belongs to the peptidase M48B family
AM1_1154	COG0776	regulation of translation
AM1_1155	COG0575	Belongs to the CDS family
AM1_1157	COG0745	RESPONSE REGULATOR receiver
AM1_1158	COG2172	sigma factor antagonist activity
AM1_1160	COG1051	belongs to the nudix hydrolase family
AM1_1161	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM1_1163	COG0456	acetyltransferase
AM1_1164	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM1_1172	COG1331	Highly conserved protein containing a thioredoxin domain
AM1_1179	COG1671	Belongs to the UPF0178 family
AM1_1182	COG0625	glutathione transferase activity
AM1_1185	COG2205	protein histidine kinase activity
AM1_1185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM1_1186	COG2205	protein histidine kinase activity
AM1_1186	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM1_1187	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM1_1196	COG0523	cobalamin synthesis protein
AM1_1204	COG5635	Nacht domain
AM1_1204	COG2319	Wd-40 repeat
AM1_1205	COG2319	Wd-40 repeat
AM1_1205	COG5635	Nacht domain
AM1_1209	COG1252	NADH dehydrogenase
AM1_1221	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM1_1222	COG0719	Fe-S assembly protein
AM1_1223	COG0396	ATPase activity
AM1_1224	COG0719	Fe-S assembly protein
AM1_1229	COG1309	transcriptional regulator
AM1_1230	COG0625	glutathione transferase activity
AM1_1244	COG4221	oxidoreductase activity
AM1_1245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM1_1246	COG1376	ErfK ybiS ycfS ynhG family protein
AM1_1247	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AM1_1248	COG0254	rRNA binding
AM1_1249	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM1_1250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AM1_1251	COG0101	tRNA pseudouridine synthase activity
AM1_1252	COG0203	ribosomal protein L17
AM1_1253	COG0202	RNA polymerase activity
AM1_1254	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM1_1255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AM1_1256	COG0646	methionine synthase
AM1_1256	COG1410	methionine synthase
AM1_1261	COG0584	glycerophosphoryl diester phosphodiesterase
AM1_1263	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AM1_1264	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM1_1266	COG2827	Endonuclease containing a URI domain
AM1_1268	COG3012	SEC-C Motif Domain Protein
AM1_1274	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM1_1275	COG2264	protein methyltransferase activity
AM1_1283	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM1_1284	COG4956	integral membrane protein (PIN domain superfamily)
AM1_1305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_1308	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_1309	COG1803	Methylglyoxal synthase
AM1_1309	COG1597	lipid kinase activity
AM1_1317	COG2207	Transcriptional regulator
AM1_1324	COG0667	Aldo Keto reductase
AM1_1325	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_1326	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AM1_1327	COG1073	alpha beta
AM1_1334	COG1309	transcriptional regulator
AM1_1335	COG1454	alcohol dehydrogenase
AM1_1336	COG1012	belongs to the aldehyde dehydrogenase family
AM1_1347	COG0159	tryptophan synthase activity
AM1_1350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM1_1352	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM1_1360	COG0606	chelatase, subunit chli
AM1_1361	COG3063	Type IV pilus biogenesis stability protein PilW
AM1_1362	COG4172	Belongs to the ABC transporter superfamily
AM1_1363	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_1365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM1_1366	COG2045	Belongs to the ComB family
AM1_1371	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_1373	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AM1_1374	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM1_1376	COG0339	signal peptide processing
AM1_1377	COG0515	serine threonine protein kinase
AM1_1377	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_1378	COG2203	Gaf domain
AM1_1378	COG0840	transmembrane signaling receptor activity
AM1_1379	COG0784	Response regulator, receiver
AM1_1379	COG2205	protein histidine kinase activity
AM1_1382	COG0303	'Molybdopterin
AM1_1384	COG0426	domain, Protein
AM1_1384	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM1_1386	COG0426	domain, Protein
AM1_1386	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM1_1389	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM1_1394	COG0114	fumarate hydratase activity
AM1_1399	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM1_1400	COG1196	nuclear chromosome segregation
AM1_1400	COG3264	Mechanosensitive ion channel
AM1_1403	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM1_1408	COG1473	amidohydrolase
AM1_1414	COG2308	Evidence 4 Homologs of previously reported genes of
AM1_1416	COG5002	protein histidine kinase activity
AM1_1416	COG5001	Diguanylate cyclase
AM1_1423	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AM1_1425	COG3903	Transcriptional regulator
AM1_1425	COG2319	Wd-40 repeat
AM1_1426	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AM1_1427	COG0546	phosphoglycolate phosphatase activity
AM1_1430	COG0512	Glutamine amidotransferase of anthranilate synthase
AM1_1431	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AM1_1432	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM1_1434	COG0047	phosphoribosylformylglycinamidine synthase activity
AM1_1435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM1_1436	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AM1_1438	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM1_1438	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM1_1441	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AM1_1444	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AM1_1445	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AM1_1449	COG0489	protein tyrosine kinase activity
AM1_1450	COG0772	Belongs to the SEDS family
AM1_1453	COG0539	negative regulation of cytoplasmic translation
AM1_1454	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AM1_1461	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM1_1468	COG2205	protein histidine kinase activity
AM1_1480	COG0745	RESPONSE REGULATOR receiver
AM1_1489	COG0762	integral membrane protein
AM1_1490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AM1_1493	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM1_1497	COG0174	glutamine synthetase
AM1_1499	COG5002	protein histidine kinase activity
AM1_1499	COG0784	Response regulator, receiver
AM1_1504	COG2239	Acts as a magnesium transporter
AM1_1506	COG0191	fructose-bisphosphate aldolase activity
AM1_1508	COG0739	heme binding
AM1_1509	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM1_1510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AM1_1514	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AM1_1525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AM1_1526	COG1063	alcohol dehydrogenase
AM1_1528	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AM1_1529	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AM1_1531	COG0509	glycine decarboxylation via glycine cleavage system
AM1_1539	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AM1_1540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM1_1552	COG1733	regulation of RNA biosynthetic process
AM1_1557	COG0784	Response regulator, receiver
AM1_1557	COG2205	protein histidine kinase activity
AM1_1565	COG4585	Histidine kinase
AM1_1566	COG2197	response regulator
AM1_1569	COG2226	methyltransferase
AM1_1573	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AM1_1578	COG0515	serine threonine protein kinase
AM1_1578	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_1584	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_1584	COG0515	serine threonine protein kinase
AM1_1585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM1_1592	COG1126	abc transporter atp-binding protein
AM1_1593	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM1_1596	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_1599	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_1601	COG1136	(ABC) transporter
AM1_1608	COG0625	glutathione transferase activity
AM1_1610	COG1733	regulation of RNA biosynthetic process
AM1_1618	COG0604	alcohol dehydrogenase
AM1_1621	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM1_1621	COG1024	Enoyl-CoA hydratase
AM1_1622	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM1_1623	COG4221	oxidoreductase activity
AM1_1629	COG5001	Diguanylate cyclase
AM1_1629	COG4251	negative regulation of phosphorylation
AM1_1629	COG2203	Gaf domain
AM1_1629	COG3706	GGDEF domain
AM1_1630	COG1049	propionate catabolic process, 2-methylcitrate cycle
AM1_1638	COG0135	phosphoribosylanthranilate isomerase activity
AM1_1639	COG0745	RESPONSE REGULATOR receiver
AM1_1640	COG0167	dihydroorotate dehydrogenase activity
AM1_1643	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AM1_1645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM1_1645	COG0574	Belongs to the PEP-utilizing enzyme family
AM1_1646	COG0589	response to stress
AM1_1649	COG1305	Transglutaminase-like
AM1_1653	COG3854	ATPases associated with a variety of cellular activities
AM1_1654	COG5002	protein histidine kinase activity
AM1_1657	COG2072	flavoprotein involved in K transport
AM1_1658	COG1166	arginine decarboxylase activity
AM1_1660	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_1662	COG0067	glutamate synthase
AM1_1662	COG0070	glutamate synthase
AM1_1662	COG0069	glutamate synthase activity
AM1_1667	COG0121	glutamine amidotransferase
AM1_1670	COG1404	Belongs to the peptidase S8 family
AM1_1675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM1_1676	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AM1_1683	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM1_1685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AM1_1688	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM1_1692	COG1032	radical SAM domain protein
AM1_1697	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM1_1698	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM1_1701	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM1_1702	COG0513	Belongs to the DEAD box helicase family
AM1_1703	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM1_1705	COG1530	ribonuclease E activity
AM1_1706	COG0412	Dienelactone hydrolase
AM1_1707	COG1725	Transcriptional regulator
AM1_1709	COG2304	oxidoreductase activity
AM1_1712	COG0612	Peptidase, M16
AM1_1717	COG0571	ribonuclease III activity
AM1_1718	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM1_1719	COG0484	heat shock protein binding
AM1_1720	COG0037	tRNA processing
AM1_1721	COG0745	RESPONSE REGULATOR receiver
AM1_1722	COG1011	Hydrolase
AM1_1726	COG0784	Response regulator, receiver
AM1_1727	COG4251	negative regulation of phosphorylation
AM1_1728	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AM1_1731	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AM1_1733	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AM1_1735	COG5002	protein histidine kinase activity
AM1_1736	COG0180	Tryptophanyl-tRNA synthetase
AM1_1737	COG0285	dihydrofolate synthase activity
AM1_1743	COG1132	(ABC) transporter
AM1_1744	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AM1_1746	COG2010	Cytochrome c
AM1_1749	COG1819	glycosyl
AM1_1752	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AM1_1753	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM1_1758	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_1765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AM1_1766	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_1772	COG0243	molybdopterin cofactor binding
AM1_1781	COG0464	growth
AM1_1781	COG4451	ribulose bisphosphate carboxylase, small
AM1_1783	COG4451	ribulose bisphosphate carboxylase, small
AM1_1785	COG1850	ribulose-bisphosphate carboxylase activity
AM1_1786	COG0454	-acetyltransferase
AM1_1789	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AM1_1793	COG0051	transcription antitermination factor activity, RNA binding
AM1_1794	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AM1_1795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM1_1796	COG0049	tRNA binding
AM1_1797	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AM1_1798	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AM1_1799	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AM1_1800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM1_1801	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AM1_1806	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AM1_1808	COG0745	RESPONSE REGULATOR receiver
AM1_1809	COG1333	cytochrome c biogenesis protein
AM1_1811	COG0772	Belongs to the SEDS family
AM1_1814	COG3659	wide pore channel activity
AM1_1819	COG1136	(ABC) transporter
AM1_1828	COG0659	secondary active sulfate transmembrane transporter activity
AM1_1829	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_1831	COG2217	Heavy metal translocating P-type atpase
AM1_1835	COG2321	neutral zinc metallopeptidase
AM1_1841	COG2203	Gaf domain
AM1_1841	COG3706	GGDEF domain
AM1_1841	COG5001	Diguanylate cyclase
AM1_1841	COG4251	negative regulation of phosphorylation
AM1_1847	COG0217	transcriptional regulatory protein
AM1_1849	COG2884	Cell division ATP-binding protein ftsE
AM1_1850	COG2177	Part of the ABC transporter FtsEX involved in
AM1_1854	COG0515	serine threonine protein kinase
AM1_1854	COG2815	serine threonine protein kinase
AM1_1863	COG1666	GTP binding
AM1_1864	COG1012	belongs to the aldehyde dehydrogenase family
AM1_1867	COG0516	GMP reductase activity
AM1_1868	COG3118	belongs to the thioredoxin family
AM1_1870	COG0784	Response regulator, receiver
AM1_1870	COG5002	protein histidine kinase activity
AM1_1870	COG2205	protein histidine kinase activity
AM1_1874	COG0693	protein deglycase activity
AM1_1876	COG0737	Belongs to the 5'-nucleotidase family
AM1_1880	COG0436	Aminotransferase
AM1_1883	COG0540	Belongs to the ATCase OTCase family
AM1_1886	COG1122	ATPase activity
AM1_1891	COG3594	Acyltransferase
AM1_1893	COG2226	methyltransferase
AM1_1895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM1_1896	COG0438	transferase activity, transferring glycosyl groups
AM1_1901	COG2226	methyltransferase
AM1_1907	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM1_1909	COG2244	polysaccharide biosynthetic process
AM1_1911	COG0438	transferase activity, transferring glycosyl groups
AM1_1916	COG2850	peptidyl-arginine hydroxylation
AM1_1917	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AM1_1922	COG1473	amidohydrolase
AM1_1929	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AM1_1930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM1_1933	COG0360	Binds together with S18 to 16S ribosomal RNA
AM1_1934	COG2200	EAL domain
AM1_1934	COG2199	diguanylate cyclase activity
AM1_1934	COG3287	FIST C domain
AM1_1938	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AM1_1939	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM1_1941	COG1058	Belongs to the CinA family
AM1_1941	COG1546	Belongs to the CinA family
AM1_1943	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AM1_1944	COG0488	(ABC) transporter
AM1_1946	COG0456	acetyltransferase
AM1_1947	COG0542	response to heat
AM1_1950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM1_1954	COG0037	tRNA processing
AM1_1957	COG0352	thiamine-phosphate diphosphorylase activity
AM1_1959	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM1_1960	COG0745	RESPONSE REGULATOR receiver
AM1_1962	COG1858	cytochrome C peroxidase
AM1_1963	COG0784	Response regulator, receiver
AM1_1963	COG5002	protein histidine kinase activity
AM1_1966	COG4191	Histidine kinase
AM1_1966	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM1_1968	COG0434	BtpA family
AM1_1969	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM1_1972	COG0494	nUDIX hydrolase
AM1_1973	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM1_1977	COG3596	GTP binding
AM1_1985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM1_1987	COG0501	Belongs to the peptidase M48B family
AM1_1993	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AM1_2009	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AM1_2011	COG1819	glycosyl
AM1_2014	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AM1_2019	COG0668	transmembrane transport
AM1_2020	COG0017	Asparaginyl-tRNA synthetase
AM1_2022	COG0297	glycogen (starch) synthase activity
AM1_2023	COG0724	RNA recognition motif
AM1_2027	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM1_2028	COG3977	Valine--pyruvate aminotransferase
AM1_2036	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AM1_2043	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM1_2044	COG1007	ATP synthesis coupled electron transport
AM1_2046	COG0644	oxidoreductase
AM1_2048	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AM1_2049	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM1_2051	COG0742	ribosomal rna small subunit methyltransferase
AM1_2057	COG0443	Heat shock 70 kDa protein
AM1_2060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM1_2061	COG0460	homoserine dehydrogenase
AM1_2067	COG0456	acetyltransferase
AM1_2069	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AM1_2070	COG0616	signal peptide processing
AM1_2073	COG2207	Transcriptional regulator
AM1_2077	COG0702	epimerase
AM1_2079	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM1_2081	COG0747	negative chemotaxis
AM1_2083	COG0793	Belongs to the peptidase S41A family
AM1_2085	COG1858	cytochrome C peroxidase
AM1_2089	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM1_2091	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AM1_2103	COG1640	4-alpha-glucanotransferase
AM1_2104	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM1_2109	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_2111	COG0735	belongs to the Fur family
AM1_2114	COG0058	SHG alpha-glucan phosphorylase activity
AM1_2115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AM1_2117	COG2267	carboxylic ester hydrolase activity
AM1_2118	COG0440	acetolactate synthase activity
AM1_2122	COG0439	Biotin carboxylase
AM1_2123	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AM1_2124	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM1_2125	COG0542	response to heat
AM1_2127	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM1_2130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_2131	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM1_2134	COG0475	glutathione-regulated potassium exporter activity
AM1_2135	COG0039	L-malate dehydrogenase activity
AM1_2145	COG2267	carboxylic ester hydrolase activity
AM1_2148	COG1024	Enoyl-CoA hydratase
AM1_2148	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM1_2149	COG0183	Belongs to the thiolase family
AM1_2150	COG1960	acyl-CoA dehydrogenase activity
AM1_2151	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM1_2151	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AM1_2156	COG2062	phosphohistidine phosphatase, SixA
AM1_2157	COG0372	Belongs to the citrate synthase family
AM1_2158	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AM1_2159	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_2163	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM1_2167	COG0537	adenosine 5'-monophosphoramidase activity
AM1_2170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM1_2171	COG0629	single-stranded DNA binding
AM1_2172	COG0151	Belongs to the GarS family
AM1_2178	COG0842	Transport permease protein
AM1_2178	COG1131	(ABC) transporter
AM1_2178	COG1716	ATPase activity
AM1_2179	COG0515	serine threonine protein kinase
AM1_2179	COG2815	serine threonine protein kinase
AM1_2180	COG1178	ABC-type Fe3 transport system permease component
AM1_2181	COG1253	flavin adenine dinucleotide binding
AM1_2182	COG0445	tRNA wobble uridine modification
AM1_2188	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM1_2189	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM1_2193	COG0517	IMP dehydrogenase activity
AM1_2193	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AM1_2194	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AM1_2195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AM1_2219	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_2222	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM1_2225	COG2072	flavoprotein involved in K transport
AM1_2232	COG2144	transferase activity, transferring acyl groups
AM1_2233	COG0732	type I restriction modification DNA specificity domain
AM1_2239	COG0438	transferase activity, transferring glycosyl groups
AM1_2240	COG2197	response regulator
AM1_2246	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_2251	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM1_2253	COG0625	glutathione transferase activity
AM1_2260	COG0583	DNA-binding transcription factor activity
AM1_2262	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM1_2283	COG1494	fructose-1,6-bisphosphatase
AM1_2285	COG1662	PFAM IS1 transposase
AM1_2289	COG0456	acetyltransferase
AM1_2289	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM1_2292	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AM1_2294	COG0515	serine threonine protein kinase
AM1_2294	COG3266	domain, Protein
AM1_2295	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AM1_2296	COG0156	8-amino-7-oxononanoate synthase activity
AM1_2299	COG4172	Belongs to the ABC transporter superfamily
AM1_2301	COG0728	peptidoglycan biosynthetic process
AM1_2302	COG0728	peptidoglycan biosynthetic process
AM1_2306	COG4221	oxidoreductase activity
AM1_2307	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM1_2309	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM1_2314	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM1_2318	COG1127	ABC transporter
AM1_2321	COG0442	prolyl-tRNA aminoacylation
AM1_2325	COG0387	Pfam Sodium calcium exchanger
AM1_2330	COG0740	serine-type endopeptidase activity
AM1_2331	COG0740	serine-type endopeptidase activity
AM1_2336	COG0456	acetyltransferase
AM1_2336	COG1846	Transcriptional regulator
AM1_2337	COG0564	pseudouridine synthase activity
AM1_2338	COG0613	PHP domain protein
AM1_2340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_2341	COG1489	DNA binding
AM1_2342	COG0602	queuosine metabolic process
AM1_2344	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM1_2345	COG1040	competence protein
AM1_2347	COG0574	Belongs to the PEP-utilizing enzyme family
AM1_2347	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM1_2349	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AM1_2352	COG0739	heme binding
AM1_2354	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AM1_2357	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_2358	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AM1_2361	COG0714	Associated with various cellular activities
AM1_2365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM1_2366	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AM1_2367	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AM1_2373	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM1_2374	COG0631	protein serine/threonine phosphatase activity
AM1_2375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM1_2380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM1_2387	COG1716	ATPase activity
AM1_2387	COG5001	Diguanylate cyclase
AM1_2389	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM1_2401	COG2176	DNA-directed DNA polymerase activity
AM1_2407	COG5433	transposase activity
AM1_2413	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM1_2414	COG0563	adenylate kinase activity
AM1_2415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AM1_2417	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM1_2419	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AM1_2423	COG0357	Ribosomal RNA small subunit methyltransferase G
AM1_2424	COG3128	pkhd-type hydroxylase
AM1_2428	COG0415	Belongs to the DNA photolyase family
AM1_2431	COG3693	PFAM glycoside hydrolase, family 10
AM1_2436	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_2440	COG0443	Heat shock 70 kDa protein
AM1_2444	COG0351	phosphomethylpyrimidine kinase
AM1_2455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AM1_2457	COG2885	chlorophyll binding
AM1_2458	COG2885	chlorophyll binding
AM1_2461	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM1_2463	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM1_2464	COG1131	(ABC) transporter
AM1_2464	COG0842	Transport permease protein
AM1_2464	COG1716	ATPase activity
AM1_2465	COG0312	modulator of DNA gyrase
AM1_2466	COG0312	modulator of DNA gyrase
AM1_2467	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM1_2468	COG0438	transferase activity, transferring glycosyl groups
AM1_2481	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_2492	COG1619	proteins homologs of microcin C7 resistance protein MccF
AM1_2495	COG3118	belongs to the thioredoxin family
AM1_2496	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM1_2497	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_2501	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AM1_2502	COG0714	Associated with various cellular activities
AM1_2504	COG2205	protein histidine kinase activity
AM1_2505	COG1672	PFAM Archaeal ATPase
AM1_2505	COG2319	Wd-40 repeat
AM1_2506	COG0515	serine threonine protein kinase
AM1_2512	COG0587	DNA-directed DNA polymerase activity
AM1_2514	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM1_2515	COG4245	von Willebrand factor, type A
AM1_2520	COG0705	Rhomboid family
AM1_2527	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM1_2528	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM1_2529	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM1_2531	COG0667	Aldo Keto reductase
AM1_2535	COG0464	growth
AM1_2537	COG2020	methyltransferase activity
AM1_2543	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_2545	COG1695	Transcriptional regulator
AM1_2553	COG0431	NADPH-dependent FMN reductase
AM1_2555	COG0475	glutathione-regulated potassium exporter activity
AM1_2555	COG0589	response to stress
AM1_2556	COG1716	ATPase activity
AM1_2558	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM1_2558	COG0140	phosphoribosyl-ATP diphosphatase activity
AM1_2561	COG3118	belongs to the thioredoxin family
AM1_2562	COG0358	DNA primase activity
AM1_2566	COG1902	pentaerythritol trinitrate reductase activity
AM1_2567	COG2010	Cytochrome c
AM1_2569	COG1858	cytochrome C peroxidase
AM1_2571	COG1566	PFAM secretion protein HlyD family protein
AM1_2573	COG0577	efflux transmembrane transporter activity
AM1_2573	COG1136	(ABC) transporter
AM1_2580	COG1595	DNA-templated transcription, initiation
AM1_2583	COG0270	DNA (cytosine-5-)-methyltransferase activity
AM1_2595	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM1_2596	COG1509	lysine 2,3-aminomutase activity
AM1_2597	COG2720	vancomycin resistance protein
AM1_2604	COG4115	mRNA cleavage
AM1_2612	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM1_2613	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AM1_2615	COG0525	valine-tRNA ligase activity
AM1_2616	COG0724	RNA recognition motif
AM1_2617	COG1047	Peptidyl-prolyl cis-trans
AM1_2620	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AM1_2620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AM1_2621	COG0436	Aminotransferase
AM1_2626	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AM1_2631	COG4447	cellulose binding
AM1_2632	COG1773	rubredoxin
AM1_2633	COG0012	GTP binding
AM1_2634	COG1982	Orn Lys Arg decarboxylase major
AM1_2637	COG0363	glucosamine-6-phosphate deaminase activity
AM1_2638	COG1716	ATPase activity
AM1_2639	COG0515	serine threonine protein kinase
AM1_2640	COG1073	alpha beta
AM1_2644	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AM1_2649	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM1_2649	COG4651	solute:proton antiporter activity
AM1_2650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM1_2651	COG1234	tRNA 3'-trailer cleavage
AM1_2652	COG0196	riboflavin kinase activity
AM1_2653	COG0714	Associated with various cellular activities
AM1_2655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AM1_2660	COG1104	cysteine desulfurase activity
AM1_2683	COG0741	lytic transglycosylase activity
AM1_2683	COG0739	heme binding
AM1_2683	COG1196	nuclear chromosome segregation
AM1_2687	COG5001	Diguanylate cyclase
AM1_2687	COG1716	ATPase activity
AM1_2688	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM1_2690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM1_2695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM1_2697	COG1252	NADH dehydrogenase
AM1_2698	COG0450	alkyl hydroperoxide reductase
AM1_2699	COG0463	Glycosyl transferase, family 2
AM1_2702	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM1_2705	COG2226	methyltransferase
AM1_2715	COG0726	polysaccharide deacetylase
AM1_2720	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AM1_2721	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_2723	COG0640	Transcriptional regulator
AM1_2726	COG2852	Protein conserved in bacteria
AM1_2730	COG2197	response regulator
AM1_2731	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AM1_2735	COG0393	Putative heavy-metal-binding
AM1_2743	COG0247	lactate metabolic process
AM1_2744	COG0277	FAD linked oxidase domain protein
AM1_2748	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM1_2751	COG4115	mRNA cleavage
AM1_2758	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM1_2766	COG0497	DNA recombination
AM1_2784	COG1053	succinate dehydrogenase
AM1_2787	COG1309	transcriptional regulator
AM1_2788	COG3152	Membrane
AM1_2790	COG2723	6-phospho-beta-galactosidase activity
AM1_2791	COG2267	carboxylic ester hydrolase activity
AM1_2792	COG0515	serine threonine protein kinase
AM1_2792	COG3266	domain, Protein
AM1_2800	COG5002	protein histidine kinase activity
AM1_2805	COG1196	nuclear chromosome segregation
AM1_2807	COG0489	protein tyrosine kinase activity
AM1_2808	COG3206	protein involved in exopolysaccharide biosynthesis
AM1_2808	COG0489	protein tyrosine kinase activity
AM1_2813	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AM1_2814	COG3250	beta-galactosidase activity
AM1_2821	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_2821	COG0515	serine threonine protein kinase
AM1_2822	COG0515	serine threonine protein kinase
AM1_2822	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_2827	COG0457	Tetratricopeptide repeat
AM1_2833	COG0010	Belongs to the arginase family
AM1_2834	COG0375	protein maturation
AM1_2837	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM1_2838	COG1116	anion transmembrane transporter activity
AM1_2840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AM1_2841	COG0515	serine threonine protein kinase
AM1_2841	COG3266	domain, Protein
AM1_2844	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM1_2849	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
AM1_2853	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM1_2854	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AM1_2857	COG0717	Belongs to the dCTP deaminase family
AM1_2858	COG3751	2OG-Fe(II) oxygenase superfamily
AM1_2859	COG2099	Precorrin-6x reductase
AM1_2860	COG5001	Diguanylate cyclase
AM1_2860	COG1716	ATPase activity
AM1_2861	COG0335	large ribosomal subunit rRNA binding
AM1_2863	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AM1_2864	COG0250	Participates in transcription elongation, termination and antitermination
AM1_2865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AM1_2866	COG0081	regulation of translation
AM1_2867	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AM1_2868	COG0222	ribosome binding
AM1_2869	COG1799	cell septum assembly
AM1_2872	COG1716	ATPase activity
AM1_2872	COG0842	Transport permease protein
AM1_2872	COG1131	(ABC) transporter
AM1_2875	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AM1_2876	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM1_2877	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM1_2878	COG3429	Glucose-6-phosphate dehydrogenase subunit
AM1_2878	COG3409	Peptidoglycan-binding domain 1 protein
AM1_2881	COG1797	cobyrinic acid a,c-diamide synthase activity
AM1_2883	COG0632	four-way junction helicase activity
AM1_2887	COG0596	Alpha beta hydrolase
AM1_2891	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AM1_2891	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM1_2893	COG2119	membrane
AM1_2894	COG2119	membrane
AM1_2900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM1_2904	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM1_2908	COG0163	prenyltransferase activity
AM1_2913	COG1940	carbohydrate kinase activity
AM1_2914	COG0504	CTP synthase activity
AM1_2915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AM1_2921	COG1253	flavin adenine dinucleotide binding
AM1_2923	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AM1_2935	COG4243	Vitamin k epoxide reductase
AM1_2936	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AM1_2937	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AM1_2939	COG3706	GGDEF domain
AM1_2940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM1_2944	COG0601	transmembrane transport
AM1_2945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AM1_2959	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_2959	COG0515	serine threonine protein kinase
AM1_2960	COG1175	transmembrane transport
AM1_2970	COG1131	(ABC) transporter
AM1_2979	COG0038	chloride channel
AM1_2981	COG1011	Hydrolase
AM1_2985	COG2223	nitrite transmembrane transporter activity
AM1_2986	COG3659	wide pore channel activity
AM1_2987	COG0243	molybdopterin cofactor binding
AM1_2989	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AM1_2990	COG0778	Nitroreductase
AM1_3002	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AM1_3004	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM1_3013	COG2166	iron-sulfur cluster assembly
AM1_3014	COG0523	cobalamin synthesis protein
AM1_3026	COG3220	belongs to the UPF0276 family
AM1_3031	COG0523	cobalamin synthesis protein
AM1_3034	COG2197	response regulator
AM1_3040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AM1_3046	COG3706	GGDEF domain
AM1_3049	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_3052	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM1_3052	COG4451	ribulose bisphosphate carboxylase, small
AM1_3053	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM1_3055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM1_3056	COG0302	gtp cyclohydrolase
AM1_3057	COG0523	cobalamin synthesis protein
AM1_3064	COG3657	addiction module killer protein
AM1_3070	COG0523	cobalamin synthesis protein
AM1_3071	COG0113	porphobilinogen synthase activity
AM1_3072	COG3443	Belongs to the bacterial solute-binding protein 9 family
AM1_3072	COG0803	Belongs to the bacterial solute-binding protein 9 family
AM1_3073	COG1121	(ABC) transporter
AM1_3074	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM1_3076	COG0584	glycerophosphoryl diester phosphodiesterase
AM1_3081	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AM1_3082	COG1472	Belongs to the glycosyl hydrolase 3 family
AM1_3087	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AM1_3089	COG0314	molybdopterin synthase activity
AM1_3092	COG0706	membrane insertase activity
AM1_3094	COG0594	ribonuclease P activity
AM1_3095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AM1_3096	COG0592	DNA-directed DNA polymerase activity
AM1_3099	COG0463	Glycosyl transferase, family 2
AM1_3100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM1_3101	COG0745	RESPONSE REGULATOR receiver
AM1_3102	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AM1_3103	COG2211	Major facilitator Superfamily
AM1_3106	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_3110	COG1012	belongs to the aldehyde dehydrogenase family
AM1_3113	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM1_3118	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AM1_3121	COG4251	negative regulation of phosphorylation
AM1_3123	COG1994	Peptidase M50
AM1_3124	COG1181	Belongs to the D-alanine--D-alanine ligase family
AM1_3127	COG2027	D-alanyl-D-alanine carboxypeptidase
AM1_3140	COG0681	Belongs to the peptidase S26 family
AM1_3143	COG0129	dihydroxy-acid dehydratase activity
AM1_3146	COG0824	Thioesterase
AM1_3147	COG3903	Transcriptional regulator
AM1_3147	COG2319	Wd-40 repeat
AM1_3154	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AM1_3159	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_3159	COG0515	serine threonine protein kinase
AM1_3160	COG3842	ATPase activity
AM1_3161	COG0629	single-stranded DNA binding
AM1_3162	COG0628	permease
AM1_3163	COG0752	glycyl-tRNA synthetase alpha subunit
AM1_3169	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM1_3173	COG0316	Belongs to the HesB IscA family
AM1_3181	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM1_3182	COG2274	protein secretion by the type I secretion system
AM1_3187	COG0789	Transcriptional regulator
AM1_3187	COG4978	Transcriptional regulator
AM1_3191	COG3266	domain, Protein
AM1_3191	COG0515	serine threonine protein kinase
AM1_3194	COG2273	Hydrolase Family 16
AM1_3194	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AM1_3195	COG0438	transferase activity, transferring glycosyl groups
AM1_3196	COG0659	secondary active sulfate transmembrane transporter activity
AM1_3197	COG0475	glutathione-regulated potassium exporter activity
AM1_3199	COG0651	ATP synthesis coupled electron transport
AM1_3207	COG2146	nitrite reductase [NAD(P)H] activity
AM1_3209	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM1_3211	COG0515	serine threonine protein kinase
AM1_3214	COG0459	protein refolding
AM1_3218	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_3225	COG0492	ferredoxin-NADP+ reductase activity
AM1_3230	COG0745	RESPONSE REGULATOR receiver
AM1_3232	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM1_3234	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_3237	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_3241	COG0745	RESPONSE REGULATOR receiver
AM1_3242	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM1_3242	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM1_3244	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM1_3250	COG0596	Alpha beta hydrolase
AM1_3250	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM1_3254	COG3852	Histidine kinase
AM1_3255	COG0492	ferredoxin-NADP+ reductase activity
AM1_3259	COG2319	Wd-40 repeat
AM1_3259	COG3903	Transcriptional regulator
AM1_3270	COG3328	transposase activity
AM1_3271	COG3328	transposase activity
AM1_3272	COG3328	transposase activity
AM1_3280	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM1_3291	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM1_3300	COG0251	oxidation-reduction process
AM1_3303	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM1_3303	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AM1_3309	COG0028	Belongs to the TPP enzyme family
AM1_3312	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AM1_3315	COG0469	pyruvate kinase activity
AM1_3316	COG1959	2 iron, 2 sulfur cluster binding
AM1_3326	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AM1_3327	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AM1_3329	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM1_3330	COG5001	Diguanylate cyclase
AM1_3330	COG5002	protein histidine kinase activity
AM1_3332	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM1_3333	COG0649	NAD binding
AM1_3337	COG3266	domain, Protein
AM1_3337	COG0515	serine threonine protein kinase
AM1_3338	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_3342	COG2211	Major facilitator Superfamily
AM1_3343	COG1722	exodeoxyribonuclease VII activity
AM1_3344	COG1570	exodeoxyribonuclease VII activity
AM1_3345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM1_3347	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM1_3348	COG1120	ATPase activity
AM1_3349	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM1_3350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM1_3352	COG0492	ferredoxin-NADP+ reductase activity
AM1_3357	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_3369	COG3794	PFAM blue (type 1) copper domain protein
AM1_3372	COG3588	fructose-bisphosphate aldolase
AM1_3374	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AM1_3382	COG2207	Transcriptional regulator
AM1_3383	COG4771	TonB-dependent receptor
AM1_3387	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_3395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM1_3397	COG4607	ABC-type enterochelin transport system periplasmic component
AM1_3401	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_3409	COG0783	Belongs to the Dps family
AM1_3410	COG0848	biopolymer transport protein
AM1_3411	COG0811	peptide transport
AM1_3414	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM1_3415	COG1120	ATPase activity
AM1_3416	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_3419	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_3427	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AM1_3428	COG0052	Belongs to the universal ribosomal protein uS2 family
AM1_3429	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM1_3435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM1_3437	COG0768	penicillin binding
AM1_3444	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AM1_3445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM1_3447	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AM1_3448	COG0544	peptidyl-prolyl cis-trans isomerase activity
AM1_3449	COG0740	serine-type endopeptidase activity
AM1_3450	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AM1_3452	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM1_3454	COG5002	protein histidine kinase activity
AM1_3454	COG5001	Diguanylate cyclase
AM1_3455	COG1193	negative regulation of DNA recombination
AM1_3461	COG0745	RESPONSE REGULATOR receiver
AM1_3462	COG0789	Transcriptional regulator
AM1_3465	COG2205	protein histidine kinase activity
AM1_3467	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AM1_3470	COG0288	reversible hydration of carbon dioxide
AM1_3472	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM1_3475	COG1662	PFAM IS1 transposase
AM1_3481	COG0745	RESPONSE REGULATOR receiver
AM1_3488	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM1_3489	COG0581	inorganic phosphate transmembrane transporter activity
AM1_3490	COG0573	inorganic phosphate transmembrane transporter activity
AM1_3491	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM1_3492	COG0640	Transcriptional regulator
AM1_3497	COG4249	Peptidase C14 caspase catalytic subunit p20
AM1_3497	COG2319	Wd-40 repeat
AM1_3498	COG5001	Diguanylate cyclase
AM1_3498	COG2203	Gaf domain
AM1_3498	COG3706	GGDEF domain
AM1_3498	COG4251	negative regulation of phosphorylation
AM1_3500	COG3540	Alkaline phosphatase
AM1_3509	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AM1_3511	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AM1_3514	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM1_3515	COG0318	PFAM AMP-dependent synthetase and ligase
AM1_3515	COG0204	Acyl-transferase
AM1_3517	COG0242	peptide deformylase activity
AM1_3527	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AM1_3528	COG0010	Belongs to the arginase family
AM1_3531	COG0154	amidase activity
AM1_3533	COG0004	ammonium transporteR
AM1_3534	COG0004	ammonium transporteR
AM1_3540	COG2720	vancomycin resistance protein
AM1_3544	COG2385	sporulation resulting in formation of a cellular spore
AM1_3550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM1_3551	COG3540	Alkaline phosphatase
AM1_3563	COG2124	cytochrome p450
AM1_3565	COG2815	serine threonine protein kinase
AM1_3565	COG0515	serine threonine protein kinase
AM1_3566	COG2204	response regulator
AM1_3567	COG4191	Histidine kinase
AM1_3567	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM1_3568	COG0784	Response regulator, receiver
AM1_3568	COG3437	response regulator, receiver
AM1_3569	COG3706	GGDEF domain
AM1_3569	COG4251	negative regulation of phosphorylation
AM1_3569	COG5001	Diguanylate cyclase
AM1_3569	COG2203	Gaf domain
AM1_3570	COG0116	Belongs to the methyltransferase superfamily
AM1_3571	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM1_3574	COG0822	iron-sulfur transferase activity
AM1_3576	COG0371	Dehydrogenase
AM1_3577	COG0436	Aminotransferase
AM1_3578	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM1_3579	COG0569	domain protein
AM1_3580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM1_3582	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AM1_3583	COG0406	alpha-ribazole phosphatase activity
AM1_3589	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM1_3590	COG0268	Binds directly to 16S ribosomal RNA
AM1_3591	COG0084	hydrolase, TatD family'
AM1_3592	COG0085	RNA polymerase activity
AM1_3593	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM1_3594	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AM1_3595	COG2267	carboxylic ester hydrolase activity
AM1_3596	COG0534	Mate efflux family protein
AM1_3599	COG2022	thiamine diphosphate biosynthetic process
AM1_3602	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM1_3609	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM1_3611	COG2226	methyltransferase
AM1_3616	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM1_3624	COG0673	inositol 2-dehydrogenase activity
AM1_3631	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AM1_3632	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AM1_3633	COG0799	negative regulation of ribosome biogenesis
AM1_3638	COG0628	permease
AM1_3642	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM1_3645	COG0515	serine threonine protein kinase
AM1_3645	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_3646	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM1_3648	COG1215	transferase activity, transferring glycosyl groups
AM1_3650	COG3769	mannosylglycerate metabolic process
AM1_3652	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AM1_3657	COG2045	Belongs to the ComB family
AM1_3658	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM1_3661	COG1732	Glycine betaine
AM1_3664	COG2082	Precorrin-8x methylmutase
AM1_3667	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM1_3669	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM1_3672	COG0483	inositol monophosphate 1-phosphatase activity
AM1_3674	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM1_3676	COG0300	oxidoreductase activity
AM1_3679	COG0735	belongs to the Fur family
AM1_3680	COG0678	peroxiredoxin activity
AM1_3681	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM1_3692	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AM1_3695	COG3328	transposase activity
AM1_3704	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM1_3707	COG3128	pkhd-type hydroxylase
AM1_3711	COG5001	Diguanylate cyclase
AM1_3711	COG4251	negative regulation of phosphorylation
AM1_3711	COG3706	GGDEF domain
AM1_3711	COG2203	Gaf domain
AM1_3712	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AM1_3715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AM1_3716	COG0589	response to stress
AM1_3717	COG0659	secondary active sulfate transmembrane transporter activity
AM1_3719	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AM1_3720	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AM1_3724	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM1_3725	COG0745	RESPONSE REGULATOR receiver
AM1_3729	COG0861	Integral membrane protein TerC family
AM1_3731	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM1_3733	COG0105	UTP biosynthetic process
AM1_3734	COG0671	phosphoesterase, PA-phosphatase related
AM1_3740	COG0840	transmembrane signaling receptor activity
AM1_3742	COG0745	RESPONSE REGULATOR receiver
AM1_3743	COG0784	Response regulator, receiver
AM1_3746	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM1_3751	COG1876	peptidase activity
AM1_3752	COG0515	serine threonine protein kinase
AM1_3752	COG3266	domain, Protein
AM1_3753	COG4948	Mandelate Racemase Muconate Lactonizing
AM1_3754	COG0318	PFAM AMP-dependent synthetase and ligase
AM1_3757	COG1396	sequence-specific DNA binding
AM1_3759	COG3239	Fatty acid desaturase
AM1_3776	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM1_3779	COG1132	(ABC) transporter
AM1_3786	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM1_3787	COG0552	protein localization to endoplasmic reticulum
AM1_3789	COG2208	phosphoserine phosphatase activity
AM1_3790	COG0006	proline dipeptidase activity
AM1_3794	COG0730	response to heat
AM1_3796	COG0308	aminopeptidase N
AM1_3804	COG0432	Pfam Uncharacterised protein family UPF0047
AM1_3815	COG1940	carbohydrate kinase activity
AM1_3822	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM1_3823	COG2226	methyltransferase
AM1_3827	COG3903	Transcriptional regulator
AM1_3827	COG2319	Wd-40 repeat
AM1_3832	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM1_3833	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AM1_3840	COG3263	regulation of cellular component size
AM1_3841	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM1_3844	COG2197	response regulator
AM1_3845	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM1_3846	COG0784	Response regulator, receiver
AM1_3846	COG2198	Histidine kinase
AM1_3846	COG2205	protein histidine kinase activity
AM1_3848	COG0701	Predicted permease
AM1_3850	COG0343	queuine tRNA-ribosyltransferase activity
AM1_3853	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM1_3853	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM1_3854	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM1_3868	COG1201	RNA secondary structure unwinding
AM1_3869	COG4251	negative regulation of phosphorylation
AM1_3870	COG4251	negative regulation of phosphorylation
AM1_3871	COG0784	Response regulator, receiver
AM1_3875	COG5001	Diguanylate cyclase
AM1_3875	COG5002	protein histidine kinase activity
AM1_3877	COG0484	heat shock protein binding
AM1_3879	COG2081	HI0933 family
AM1_3880	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM1_3882	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AM1_3885	COG2010	Cytochrome c
AM1_3886	COG2010	Cytochrome c
AM1_3889	COG2329	Antibiotic biosynthesis monooxygenase
AM1_3890	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_3892	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
AM1_3896	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM1_3907	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM1_3912	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_3912	COG0515	serine threonine protein kinase
AM1_3916	COG0745	RESPONSE REGULATOR receiver
AM1_3917	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM1_3918	COG1194	a g-specific adenine glycosylase
AM1_3925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_3926	COG2091	lysine biosynthetic process via aminoadipic acid
AM1_3927	COG0426	domain, Protein
AM1_3927	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM1_3932	COG0511	ligase activity, forming carbon-carbon bonds
AM1_3934	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AM1_3937	COG0745	RESPONSE REGULATOR receiver
AM1_3938	COG3932	Exopolysaccharide synthesis, ExoD
AM1_3940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM1_3944	COG0181	hydroxymethylbilane synthase activity
AM1_3946	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM1_3947	COG0205	6-phosphofructokinase activity
AM1_3948	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM1_3951	COG3903	Transcriptional regulator
AM1_3951	COG2319	Wd-40 repeat
AM1_3952	COG0515	serine threonine protein kinase
AM1_3954	COG0792	nuclease activity
AM1_3956	COG0747	negative chemotaxis
AM1_3957	COG0633	Ferredoxin
AM1_3965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AM1_3966	COG1555	photosystem II stabilization
AM1_3968	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM1_3971	COG0330	HflC and HflK could
AM1_3977	COG0501	Belongs to the peptidase M48B family
AM1_3978	COG0148	phosphopyruvate hydratase activity
AM1_3979	COG0346	lactoylglutathione lyase activity
AM1_3981	COG3659	wide pore channel activity
AM1_3982	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AM1_3983	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AM1_3984	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AM1_3988	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM1_3989	COG0483	inositol monophosphate 1-phosphatase activity
AM1_3990	COG0484	heat shock protein binding
AM1_3991	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AM1_3992	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM1_3997	COG0436	Aminotransferase
AM1_3998	COG1842	Phage shock protein A
AM1_4001	COG0667	Aldo Keto reductase
AM1_4002	COG0372	Belongs to the citrate synthase family
AM1_4012	COG0596	Alpha beta hydrolase
AM1_4017	COG0384	phenazine biosynthesis protein PhzF
AM1_4021	COG0438	transferase activity, transferring glycosyl groups
AM1_4031	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
AM1_4033	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_4036	COG0515	serine threonine protein kinase
AM1_4041	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AM1_4042	COG5322	oxidoreductase activity
AM1_4047	COG2226	methyltransferase
AM1_4050	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AM1_4052	COG4581	dead DEAH box helicase
AM1_4053	COG0745	RESPONSE REGULATOR receiver
AM1_4054	COG0643	Histidine kinase
AM1_4054	COG2198	Histidine kinase
AM1_4055	COG0840	transmembrane signaling receptor activity
AM1_4059	COG1573	uracil-dna glycosylase
AM1_4063	COG0750	zinc metalloprotease
AM1_4064	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM1_4065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AM1_4068	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AM1_4070	COG0215	cysteine-tRNA ligase activity
AM1_4072	COG1716	ATPase activity
AM1_4072	COG5001	Diguanylate cyclase
AM1_4074	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_4075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM1_4078	COG3328	transposase activity
AM1_4091	COG1943	Transposase
AM1_4094	COG3265	gluconokinase activity
AM1_4097	COG1121	(ABC) transporter
AM1_4098	COG0228	four-way junction DNA binding
AM1_4100	COG1702	phosphate starvation-inducible protein PhoH
AM1_4106	COG0336	Belongs to the RNA methyltransferase TrmD family
AM1_4107	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM1_4108	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AM1_4118	COG0702	epimerase
AM1_4121	COG2183	response to ionizing radiation
AM1_4125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AM1_4135	COG0006	proline dipeptidase activity
AM1_4136	COG0438	transferase activity, transferring glycosyl groups
AM1_4137	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM1_4138	COG0456	acetyltransferase
AM1_4139	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM1_4144	COG0697	spore germination
AM1_4147	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM1_4149	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AM1_4160	COG0697	spore germination
AM1_4161	COG2124	cytochrome p450
AM1_4165	COG0347	Belongs to the P(II) protein family
AM1_4171	COG2084	Dehydrogenase
AM1_4174	COG0583	DNA-binding transcription factor activity
AM1_4182	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM1_4183	COG1285	pathogenesis
AM1_4189	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AM1_4189	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_4200	COG1366	Belongs to the anti-sigma-factor antagonist family
AM1_4208	COG2340	Cysteine-rich secretory protein family
AM1_4210	COG2304	oxidoreductase activity
AM1_4211	COG0640	Transcriptional regulator
AM1_4212	COG2912	Transglutaminase-like superfamily
AM1_4214	COG5002	protein histidine kinase activity
AM1_4216	COG0557	exoribonuclease II activity
AM1_4217	COG0704	Plays a role in the regulation of phosphate uptake
AM1_4234	COG0137	argininosuccinate synthase activity
AM1_4236	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM1_4239	COG1077	Cell shape determining protein MreB Mrl
AM1_4240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AM1_4245	COG1492	cobalamin metabolic process
AM1_4247	COG3956	TIGRFAM MazG family protein
AM1_4269	COG2720	vancomycin resistance protein
AM1_4272	COG0166	Belongs to the GPI family
AM1_4273	COG1716	ATPase activity
AM1_4275	COG2205	protein histidine kinase activity
AM1_4276	COG3022	response to hydroperoxide
AM1_4282	COG2198	Histidine kinase
AM1_4282	COG5002	protein histidine kinase activity
AM1_4282	COG0784	Response regulator, receiver
AM1_4285	COG1132	(ABC) transporter
AM1_4295	COG2319	Wd-40 repeat
AM1_4295	COG4249	Peptidase C14 caspase catalytic subunit p20
AM1_4304	COG2197	response regulator
AM1_4314	COG5001	Diguanylate cyclase
AM1_4314	COG4251	negative regulation of phosphorylation
AM1_4314	COG3706	GGDEF domain
AM1_4314	COG2203	Gaf domain
AM1_4318	COG0515	serine threonine protein kinase
AM1_4319	COG0515	serine threonine protein kinase
AM1_4319	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_4320	COG0515	serine threonine protein kinase
AM1_4321	COG0515	serine threonine protein kinase
AM1_4323	COG0515	serine threonine protein kinase
AM1_4324	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AM1_4329	COG2890	protein-(glutamine-N5) methyltransferase activity
AM1_4331	COG0686	Belongs to the AlaDH PNT family
AM1_4335	COG2852	Protein conserved in bacteria
AM1_4341	COG0612	Peptidase, M16
AM1_4342	COG3210	domain, Protein
AM1_4344	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AM1_4347	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM1_4348	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM1_4350	COG1691	(AIR) carboxylase
AM1_4352	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AM1_4353	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_4355	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
AM1_4356	COG1187	pseudouridine synthase activity
AM1_4357	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM1_4360	COG0134	indole-3-glycerol-phosphate synthase activity
AM1_4361	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM1_4362	COG1994	Peptidase M50
AM1_4362	COG0517	IMP dehydrogenase activity
AM1_4364	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_4366	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM1_4367	COG0284	orotidine-5'-phosphate decarboxylase activity
AM1_4368	COG2003	Belongs to the UPF0758 family
AM1_4369	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM1_4373	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AM1_4373	COG3264	Mechanosensitive ion channel
AM1_4374	COG1304	FMN binding
AM1_4376	COG0210	DNA helicase
AM1_4377	COG0726	polysaccharide deacetylase
AM1_4381	COG0531	amino acid
AM1_4387	COG0583	DNA-binding transcription factor activity
AM1_4389	COG0149	triose-phosphate isomerase activity
AM1_4391	COG1132	(ABC) transporter
AM1_4392	COG0741	lytic transglycosylase activity
AM1_4392	COG0739	heme binding
AM1_4392	COG1196	nuclear chromosome segregation
AM1_4403	COG1333	cytochrome c biogenesis protein
AM1_4403	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AM1_4411	COG0459	protein refolding
AM1_4412	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM1_4415	COG0165	Argininosuccinate lyase
AM1_4417	COG0395	ABC-type sugar transport system, permease component
AM1_4421	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AM1_4424	COG1214	PFAM Peptidase M22, glycoprotease
AM1_4425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM1_4427	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AM1_4428	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM1_4428	COG0519	Catalyzes the synthesis of GMP from XMP
AM1_4430	COG2205	protein histidine kinase activity
AM1_4430	COG2202	Pas domain
AM1_4442	COG0534	Mate efflux family protein
AM1_4444	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AM1_4447	COG1132	(ABC) transporter
AM1_4449	COG3258	Cytochrome c
AM1_4452	COG0805	protein transport
AM1_4459	COG0793	Belongs to the peptidase S41A family
AM1_4460	COG1346	cytolysis
AM1_4461	COG1380	Effector of murein hydrolase LrgA
AM1_4462	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM1_4475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM1_4480	COG1672	PFAM Archaeal ATPase
AM1_4480	COG2319	Wd-40 repeat
AM1_4494	COG0519	Catalyzes the synthesis of GMP from XMP
AM1_4498	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AM1_4499	COG0187	DNA topoisomerase II activity
AM1_4499	COG1372	Participates in initiation and elongation during chromosome replication
AM1_4502	COG0170	dolichyl monophosphate biosynthetic process
AM1_4505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AM1_4506	COG0023	Translation Initiation Factor
AM1_4512	COG0788	formyltetrahydrofolate deformylase activity
AM1_4517	COG1070	Carbohydrate kinase
AM1_4537	COG5001	Diguanylate cyclase
AM1_4537	COG1716	ATPase activity
AM1_4538	COG0018	arginyl-trna synthetase
AM1_4540	COG2226	methyltransferase
AM1_4541	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM1_4542	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_4542	COG0515	serine threonine protein kinase
AM1_4546	COG1316	TRANSCRIPTIONal
AM1_4548	COG1063	alcohol dehydrogenase
AM1_4549	COG1051	belongs to the nudix hydrolase family
AM1_4550	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AM1_4554	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AM1_4555	COG0539	negative regulation of cytoplasmic translation
AM1_4556	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AM1_4563	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM1_4564	COG2046	Belongs to the sulfate adenylyltransferase family
AM1_4566	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM1_4568	COG1490	D-aminoacyl-tRNA deacylase activity
AM1_4569	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM1_4571	COG5001	Diguanylate cyclase
AM1_4571	COG4251	negative regulation of phosphorylation
AM1_4571	COG2203	Gaf domain
AM1_4571	COG3706	GGDEF domain
AM1_4572	COG3240	lipase activity
AM1_4576	COG1215	transferase activity, transferring glycosyl groups
AM1_4579	COG0857	belongs to the CobB CobQ family
AM1_4581	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AM1_4583	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM1_4586	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_4590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_4592	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM1_4593	COG0662	Cupin 2, conserved barrel domain protein
AM1_4593	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AM1_4597	COG0259	pyridoxamine-phosphate oxidase activity
AM1_4606	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM1_4608	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AM1_4612	COG1672	PFAM Archaeal ATPase
AM1_4612	COG2319	Wd-40 repeat
AM1_4616	COG0515	serine threonine protein kinase
AM1_4617	COG0583	DNA-binding transcription factor activity
AM1_4618	COG0157	Belongs to the NadC ModD family
AM1_4619	COG1845	cytochrome c oxidase, subunit III
AM1_4620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM1_4621	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM1_4623	COG0109	protoheme IX farnesyltransferase activity
AM1_4624	COG1131	(ABC) transporter
AM1_4633	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AM1_4634	COG1381	Involved in DNA repair and RecF pathway recombination
AM1_4636	COG0438	transferase activity, transferring glycosyl groups
AM1_4636	COG0297	glycogen (starch) synthase activity
AM1_4637	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AM1_4640	COG1543	Belongs to the glycosyl hydrolase 57 family
AM1_4642	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AM1_4644	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AM1_4645	COG2894	cell division
AM1_4646	COG0850	regulation of cytokinetic process
AM1_4648	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AM1_4651	COG4166	transmembrane transport
AM1_4654	COG1587	Uroporphyrinogen-III synthase
AM1_4655	COG1595	DNA-templated transcription, initiation
AM1_4657	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AM1_4659	COG3239	Fatty acid desaturase
AM1_4660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM1_4662	COG0758	DNA mediated transformation
AM1_4662	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AM1_4663	COG0242	peptide deformylase activity
AM1_4665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AM1_4666	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AM1_4667	COG0793	Belongs to the peptidase S41A family
AM1_4668	COG1078	dGTPase activity
AM1_4670	COG0328	RNA-DNA hybrid ribonuclease activity
AM1_4672	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AM1_4673	COG1836	PFAM Integral membrane protein DUF92
AM1_4676	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AM1_4696	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AM1_4697	COG0088	Forms part of the polypeptide exit tunnel
AM1_4698	COG0089	rRNA binding
AM1_4699	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AM1_4700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AM1_4701	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AM1_4702	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AM1_4703	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AM1_4704	COG0255	Belongs to the universal ribosomal protein uL29 family
AM1_4705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AM1_4706	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AM1_4707	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AM1_4708	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AM1_4709	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AM1_4710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AM1_4711	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AM1_4712	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AM1_4713	COG0200	Binds to the 23S rRNA
AM1_4714	COG0201	protein transport
AM1_4715	COG0563	adenylate kinase activity
AM1_4716	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AM1_4730	COG4566	intracellular signal transduction
AM1_4731	COG2897	thiosulfate sulfurtransferase activity
AM1_4732	COG5635	Nacht domain
AM1_4732	COG2319	Wd-40 repeat
AM1_4734	COG2852	Protein conserved in bacteria
AM1_4737	COG1672	PFAM Archaeal ATPase
AM1_4737	COG2319	Wd-40 repeat
AM1_4738	COG4453	Protein conserved in bacteria
AM1_4740	COG1609	Transcriptional regulator
AM1_4753	COG2255	four-way junction helicase activity
AM1_4754	COG1690	Belongs to the RtcB family
AM1_4755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM1_4760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AM1_4761	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM1_4763	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_4767	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AM1_4768	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AM1_4769	COG1104	cysteine desulfurase activity
AM1_4772	COG5001	Diguanylate cyclase
AM1_4799	COG2264	protein methyltransferase activity
AM1_4803	COG0113	porphobilinogen synthase activity
AM1_4805	COG0133	tryptophan synthase activity
AM1_4810	COG0557	exoribonuclease II activity
AM1_4812	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AM1_4813	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM1_4818	COG1064	alcohol dehydrogenase
AM1_4821	COG1324	tolerance protein
AM1_4825	COG1562	ergosterol biosynthetic process
AM1_4826	COG0493	'glutamate synthase
AM1_4826	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AM1_4828	COG2226	methyltransferase
AM1_4836	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM1_4838	COG0640	Transcriptional regulator
AM1_4839	COG3118	belongs to the thioredoxin family
AM1_4840	COG1902	pentaerythritol trinitrate reductase activity
AM1_4844	COG1879	ABC-type sugar transport system periplasmic component
AM1_4845	COG1657	PFAM Prenyltransferase squalene oxidase
AM1_4848	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AM1_4849	COG0793	Belongs to the peptidase S41A family
AM1_4850	COG0438	transferase activity, transferring glycosyl groups
AM1_4852	COG1429	ligase activity, forming nitrogen-metal bonds
AM1_4853	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AM1_4855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AM1_4857	COG0612	Peptidase, M16
AM1_4859	COG0612	Peptidase, M16
AM1_4861	COG0489	protein tyrosine kinase activity
AM1_4861	COG3206	protein involved in exopolysaccharide biosynthesis
AM1_4868	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AM1_4872	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM1_4884	COG1505	serine-type exopeptidase activity
AM1_4885	COG1505	serine-type exopeptidase activity
AM1_4889	COG0352	thiamine-phosphate diphosphorylase activity
AM1_4890	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM1_4892	COG3063	Type IV pilus biogenesis stability protein PilW
AM1_4893	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM1_4894	COG0271	Belongs to the BolA IbaG family
AM1_4897	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AM1_4899	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM1_4899	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AM1_4901	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM1_4902	COG0848	biopolymer transport protein
AM1_4903	COG0811	peptide transport
AM1_4905	COG0824	Thioesterase
AM1_4906	COG1672	PFAM Archaeal ATPase
AM1_4907	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AM1_4908	COG0681	Belongs to the peptidase S26 family
AM1_4909	COG0142	geranyltranstransferase activity
AM1_4910	COG0492	ferredoxin-NADP+ reductase activity
AM1_4913	COG0572	uridine kinase
AM1_4914	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM1_4915	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AM1_4917	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_4921	COG0589	response to stress
AM1_4929	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AM1_4933	COG0586	Pfam SNARE associated Golgi protein
AM1_4940	COG2084	Dehydrogenase
AM1_4948	COG2197	response regulator
AM1_4950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AM1_4951	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM1_4952	COG1121	(ABC) transporter
AM1_4963	COG3063	Type IV pilus biogenesis stability protein PilW
AM1_4972	COG0793	Belongs to the peptidase S41A family
AM1_4974	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AM1_4978	COG0723	plastoquinol--plastocyanin reductase activity
AM1_4979	COG2203	Gaf domain
AM1_4979	COG3706	GGDEF domain
AM1_4979	COG4251	negative regulation of phosphorylation
AM1_4979	COG5001	Diguanylate cyclase
AM1_4980	COG0745	RESPONSE REGULATOR receiver
AM1_4981	COG5002	protein histidine kinase activity
AM1_4981	COG5001	Diguanylate cyclase
AM1_4982	COG2234	aminopeptidase activity
AM1_4989	COG1672	PFAM Archaeal ATPase
AM1_4989	COG2319	Wd-40 repeat
AM1_4994	COG0604	alcohol dehydrogenase
AM1_4996	COG4191	Histidine kinase
AM1_5005	COG3237	CsbD-like
AM1_5006	COG5433	transposase activity
AM1_5013	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM1_5014	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AM1_5034	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_5035	COG0402	S-adenosylhomocysteine deaminase activity
AM1_5038	COG0577	efflux transmembrane transporter activity
AM1_5038	COG1136	(ABC) transporter
AM1_5039	COG1136	(ABC) transporter
AM1_5046	COG1555	photosystem II stabilization
AM1_5047	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM1_5048	COG0517	IMP dehydrogenase activity
AM1_5048	COG1994	Peptidase M50
AM1_5049	COG0589	response to stress
AM1_5051	COG5002	protein histidine kinase activity
AM1_5053	COG3781	membrane
AM1_5056	COG0745	RESPONSE REGULATOR receiver
AM1_5058	COG5002	protein histidine kinase activity
AM1_5060	COG0668	transmembrane transport
AM1_5068	COG2205	protein histidine kinase activity
AM1_5074	COG1090	epimerase
AM1_5076	COG2201	protein-glutamate methylesterase activity
AM1_5078	COG0840	transmembrane signaling receptor activity
AM1_5080	COG0784	Response regulator, receiver
AM1_5081	COG3437	response regulator, receiver
AM1_5083	COG2226	methyltransferase
AM1_5085	COG0398	Pfam SNARE associated Golgi protein
AM1_5086	COG0398	Pfam SNARE associated Golgi protein
AM1_5093	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM1_5096	COG0745	RESPONSE REGULATOR receiver
AM1_5099	COG1620	l-lactate permease
AM1_5103	COG0829	nickel cation binding
AM1_5104	COG0831	urea catabolic process
AM1_5106	COG0832	Belongs to the urease beta subunit family
AM1_5107	COG2205	protein histidine kinase activity
AM1_5107	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM1_5109	COG0804	urea catabolic process
AM1_5120	COG1132	(ABC) transporter
AM1_5122	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AM1_5123	COG0033	Phosphoglucomutase
AM1_5128	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM1_5135	COG0784	Response regulator, receiver
AM1_5135	COG2198	Histidine kinase
AM1_5135	COG2205	protein histidine kinase activity
AM1_5136	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AM1_5137	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AM1_5138	COG0009	L-threonylcarbamoyladenylate synthase
AM1_5143	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM1_5145	COG5002	protein histidine kinase activity
AM1_5147	COG5433	transposase activity
AM1_5148	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_5150	COG0514	ATP-dependent DNA helicase (RecQ)
AM1_5154	COG3300	MHYT domain
AM1_5154	COG5001	Diguanylate cyclase
AM1_5155	COG2124	cytochrome p450
AM1_5164	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM1_5165	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AM1_5166	COG1116	anion transmembrane transporter activity
AM1_5166	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM1_5167	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM1_5168	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM1_5169	COG0745	RESPONSE REGULATOR receiver
AM1_5170	COG5002	protein histidine kinase activity
AM1_5180	COG3266	domain, Protein
AM1_5180	COG0515	serine threonine protein kinase
AM1_5185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AM1_5186	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AM1_5189	COG1077	Cell shape determining protein MreB Mrl
AM1_5190	COG1175	transmembrane transport
AM1_5192	COG1716	ATPase activity
AM1_5193	COG0505	Belongs to the CarA family
AM1_5195	COG0596	Alpha beta hydrolase
AM1_5196	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM1_5200	COG0673	inositol 2-dehydrogenase activity
AM1_5202	COG0783	Belongs to the Dps family
AM1_5204	COG3937	granule-associated protein
AM1_5208	COG0515	serine threonine protein kinase
AM1_5208	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_5218	COG3268	Saccharopine dehydrogenase
AM1_5221	COG3657	addiction module killer protein
AM1_5222	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_5223	COG0756	dUTP diphosphatase activity
AM1_5225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM1_5227	COG5001	Diguanylate cyclase
AM1_5227	COG1716	ATPase activity
AM1_5228	COG3264	Mechanosensitive ion channel
AM1_5228	COG1196	nuclear chromosome segregation
AM1_5239	COG2032	superoxide dismutase activity
AM1_5246	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM1_5248	COG3659	wide pore channel activity
AM1_5253	COG0501	Belongs to the peptidase M48B family
AM1_5255	COG0481	GTPase activity
AM1_5256	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AM1_5261	COG5002	protein histidine kinase activity
AM1_5262	COG0745	RESPONSE REGULATOR receiver
AM1_5264	COG0786	glutamate:sodium symporter activity
AM1_5265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM1_5275	COG0714	Associated with various cellular activities
AM1_5276	COG0714	Associated with various cellular activities
AM1_5300	COG0438	transferase activity, transferring glycosyl groups
AM1_5302	COG2319	Wd-40 repeat
AM1_5302	COG3903	Transcriptional regulator
AM1_5305	COG1283	sodium-dependent phosphate transmembrane transporter activity
AM1_5308	COG5002	protein histidine kinase activity
AM1_5308	COG2205	protein histidine kinase activity
AM1_5308	COG0784	Response regulator, receiver
AM1_5315	COG0668	transmembrane transport
AM1_5325	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AM1_5327	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AM1_5330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM1_5334	COG0583	DNA-binding transcription factor activity
AM1_5346	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM1_5348	COG2259	Doxx family
AM1_5349	COG1372	Participates in initiation and elongation during chromosome replication
AM1_5349	COG0305	Participates in initiation and elongation during chromosome replication
AM1_5349	COG1372	Participates in initiation and elongation during chromosome replication
AM1_5349	COG0305	Participates in initiation and elongation during chromosome replication
AM1_5350	COG0359	binds to the 23S rRNA
AM1_5359	COG3266	domain, Protein
AM1_5359	COG0515	serine threonine protein kinase
AM1_5361	COG1187	pseudouridine synthase activity
AM1_5362	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AM1_5363	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM1_5365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AM1_5366	COG1799	cell septum assembly
AM1_5367	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AM1_5369	COG3842	ATPase activity
AM1_5371	COG0596	Alpha beta hydrolase
AM1_5373	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AM1_5374	COG0739	heme binding
AM1_5378	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_5379	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM1_5380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM1_5381	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM1_5382	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AM1_5383	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM1_5383	COG4451	ribulose bisphosphate carboxylase, small
AM1_5386	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM1_5387	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM1_5392	COG1597	lipid kinase activity
AM1_5392	COG1803	Methylglyoxal synthase
AM1_5405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AM1_5408	COG1444	tRNA N-acetyltransferase activity
AM1_5411	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AM1_5413	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AM1_5414	COG0559	Belongs to the binding-protein-dependent transport system permease family
AM1_5416	COG1943	Transposase
AM1_5419	COG1606	tRNA processing
AM1_5420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AM1_5422	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AM1_5428	COG0123	including yeast histone deacetylase and acetoin utilization protein
AM1_5434	COG2319	Wd-40 repeat
AM1_5434	COG4249	Peptidase C14 caspase catalytic subunit p20
AM1_5436	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM1_5437	COG1480	7TM receptor with intracellular HD hydrolase
AM1_5440	COG0517	IMP dehydrogenase activity
AM1_5440	COG0516	GMP reductase activity
AM1_5443	COG3118	belongs to the thioredoxin family
AM1_5447	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_5461	COG0617	tRNA 3'-terminal CCA addition
AM1_5468	COG1917	Cupin 2, conserved barrel domain protein
AM1_5468	COG4977	sequence-specific DNA binding
AM1_5469	COG2319	Wd-40 repeat
AM1_5469	COG3903	Transcriptional regulator
AM1_5478	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM1_5480	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_5480	COG0515	serine threonine protein kinase
AM1_5482	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_5483	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM1_5485	COG2135	peptidase activity
AM1_5486	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM1_5490	COG0347	Belongs to the P(II) protein family
AM1_5494	COG0450	alkyl hydroperoxide reductase
AM1_5497	COG0194	GDP metabolic process
AM1_5498	COG2052	Domain of unknown function (DUF370)
AM1_5507	COG0233	cytoplasmic translational termination
AM1_5513	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AM1_5514	COG0193	aminoacyl-tRNA hydrolase activity
AM1_5516	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM1_5517	COG0346	lactoylglutathione lyase activity
AM1_5521	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM1_5522	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM1_5523	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM1_5526	COG2048	Heterodisulfide reductase, subunit B
AM1_5528	COG2205	protein histidine kinase activity
AM1_5528	COG3437	response regulator, receiver
AM1_5528	COG3850	Histidine kinase
AM1_5528	COG4999	Histidine kinase
AM1_5529	COG0556	nucleotide-excision repair
AM1_5539	COG5002	protein histidine kinase activity
AM1_5543	COG1234	tRNA 3'-trailer cleavage
AM1_5546	COG0297	glycogen (starch) synthase activity
AM1_5548	COG0438	transferase activity, transferring glycosyl groups
AM1_5549	COG0438	transferase activity, transferring glycosyl groups
AM1_5550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AM1_5551	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AM1_5553	COG0793	Belongs to the peptidase S41A family
AM1_5555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AM1_5556	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM1_5557	COG0724	RNA recognition motif
AM1_5559	COG0482	sulfurtransferase activity
AM1_5562	COG1022	Amp-dependent synthetase and ligase
AM1_5564	COG1429	ligase activity, forming nitrogen-metal bonds
AM1_5570	COG0095	Lipoate-protein ligase
AM1_5571	COG0517	IMP dehydrogenase activity
AM1_5571	COG1994	Peptidase M50
AM1_5575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM1_5576	COG0189	ligase activity
AM1_5577	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM1_5582	COG4279	zinc finger
AM1_5586	COG1215	transferase activity, transferring glycosyl groups
AM1_5591	COG0514	ATP-dependent DNA helicase (RecQ)
AM1_5595	COG1943	Transposase
AM1_5596	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AM1_5599	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AM1_5599	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM1_5604	COG4399	Belongs to the UPF0754 family
AM1_5605	COG0631	protein serine/threonine phosphatase activity
AM1_5606	COG1131	(ABC) transporter
AM1_5607	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM1_5608	COG3937	granule-associated protein
AM1_5610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM1_5613	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AM1_5613	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AM1_5620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AM1_5623	COG5001	Diguanylate cyclase
AM1_5623	COG5002	protein histidine kinase activity
AM1_5624	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM1_5628	COG0628	permease
AM1_5631	COG0003	Pfam Anion-transporting ATPase
AM1_5632	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_5633	COG0825	malonyl-CoA metabolic process
AM1_5634	COG0300	oxidoreductase activity
AM1_5635	COG0302	gtp cyclohydrolase
AM1_5638	COG2205	protein histidine kinase activity
AM1_5638	COG0784	Response regulator, receiver
AM1_5644	COG0418	dihydroorotase activity
AM1_5646	COG2994	toxin metabolic process
AM1_5651	COG0668	transmembrane transport
AM1_5662	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AM1_5667	COG2204	response regulator
AM1_5668	COG2205	protein histidine kinase activity
AM1_5668	COG0784	Response regulator, receiver
AM1_5687	COG1672	PFAM Archaeal ATPase
AM1_5687	COG2319	Wd-40 repeat
AM1_5688	COG0784	Response regulator, receiver
AM1_5688	COG2205	protein histidine kinase activity
AM1_5688	COG5002	protein histidine kinase activity
AM1_5689	COG0121	glutamine amidotransferase
AM1_5690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_5691	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AM1_5692	COG0443	Heat shock 70 kDa protein
AM1_5693	COG0484	heat shock protein binding
AM1_5696	COG3046	protein related to deoxyribodipyrimidine photolyase
AM1_5699	COG0515	serine threonine protein kinase
AM1_5699	COG3266	domain, Protein
AM1_5700	COG0515	serine threonine protein kinase
AM1_5701	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AM1_5704	COG0784	Response regulator, receiver
AM1_5704	COG2205	protein histidine kinase activity
AM1_5704	COG5002	protein histidine kinase activity
AM1_5706	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AM1_5714	COG1216	Glycosyl transferase, family 2
AM1_5720	COG1132	(ABC) transporter
AM1_5721	COG1215	transferase activity, transferring glycosyl groups
AM1_5722	COG1045	serine acetyltransferase
AM1_5727	COG0438	transferase activity, transferring glycosyl groups
AM1_5729	COG0438	transferase activity, transferring glycosyl groups
AM1_5733	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM1_5737	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AM1_5742	COG0316	Belongs to the HesB IscA family
AM1_5743	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AM1_5743	COG0662	Cupin 2, conserved barrel domain protein
AM1_5748	COG2385	sporulation resulting in formation of a cellular spore
AM1_5749	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AM1_5751	COG1131	(ABC) transporter
AM1_5753	COG0473	3-isopropylmalate dehydrogenase activity
AM1_5755	COG0515	serine threonine protein kinase
AM1_5755	COG3266	domain, Protein
AM1_5758	COG1494	fructose-1,6-bisphosphatase
AM1_5759	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AM1_5760	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AM1_5762	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM1_5764	COG0367	asparagine synthase
AM1_5766	COG4106	trans-aconitate 2-methyltransferase activity
AM1_5778	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AM1_5779	COG0138	bifunctional purine biosynthesis protein purh
AM1_5780	COG2124	cytochrome p450
AM1_5783	COG0515	serine threonine protein kinase
AM1_5783	COG3064	Membrane
AM1_5783	COG4991	sh3 domain protein
AM1_5784	COG1801	Protein of unknown function DUF72
AM1_5785	COG0488	(ABC) transporter
AM1_5787	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM1_5788	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM1_5796	COG3394	polysaccharide catabolic process
AM1_5798	COG1032	radical SAM domain protein
AM1_5801	COG0523	cobalamin synthesis protein
AM1_5843	COG1073	alpha beta
AM1_5858	COG0745	RESPONSE REGULATOR receiver
AM1_5858	COG3706	GGDEF domain
AM1_5863	COG3316	Transposase and inactivated derivatives
AM1_5876	COG0739	heme binding
AM1_5894	COG4251	negative regulation of phosphorylation
AM1_5896	COG0784	Response regulator, receiver
AM1_5897	COG4251	negative regulation of phosphorylation
AM1_5899	COG1846	Transcriptional regulator
AM1_5900	COG0697	spore germination
AM1_5902	COG1950	PFAM Membrane protein of
AM1_5903	COG0435	Glutathione S-transferase
AM1_5905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AM1_5906	COG0776	regulation of translation
AM1_5920	COG1185	polyribonucleotide nucleotidyltransferase activity
AM1_5922	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM1_5924	COG4251	negative regulation of phosphorylation
AM1_5927	COG0326	Molecular chaperone. Has ATPase activity
AM1_5930	COG0431	NADPH-dependent FMN reductase
AM1_5932	COG0515	serine threonine protein kinase
AM1_5932	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_5937	COG1160	GTP binding
AM1_5941	COG0483	inositol monophosphate 1-phosphatase activity
AM1_5943	COG4178	(ABC) transporter
AM1_5953	COG1733	regulation of RNA biosynthetic process
AM1_5955	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM1_5955	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AM1_5959	COG2988	succinylglutamate desuccinylase activity
AM1_5960	COG3706	GGDEF domain
AM1_5966	COG3903	Transcriptional regulator
AM1_5966	COG2319	Wd-40 repeat
AM1_5974	COG0004	ammonium transporteR
AM1_5978	COG1662	PFAM IS1 transposase
AM1_5988	COG0410	ABC transporter
AM1_5989	COG0411	ABC transporter
AM1_5993	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM1_5997	COG5002	protein histidine kinase activity
AM1_5997	COG0784	Response regulator, receiver
AM1_6004	COG0716	FMN binding
AM1_6005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AM1_6006	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_6007	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM1_6008	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM1_6011	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM1_6014	COG2133	pyrroloquinoline quinone binding
AM1_6015	COG3903	Transcriptional regulator
AM1_6015	COG2319	Wd-40 repeat
AM1_6030	COG1271	oxidase subunit
AM1_6038	COG1131	(ABC) transporter
AM1_6041	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AM1_6048	COG0438	transferase activity, transferring glycosyl groups
AM1_6050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM1_6052	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM1_6053	COG3706	GGDEF domain
AM1_6053	COG0745	RESPONSE REGULATOR receiver
AM1_6055	COG0405	Gamma-glutamyltransferase
AM1_6060	COG0076	glutamate decarboxylase activity
AM1_6067	COG4191	Histidine kinase
AM1_6069	COG0745	RESPONSE REGULATOR receiver
AM1_6069	COG3706	GGDEF domain
AM1_6070	COG0784	Response regulator, receiver
AM1_6070	COG2205	protein histidine kinase activity
AM1_6071	COG3903	Transcriptional regulator
AM1_6071	COG2319	Wd-40 repeat
AM1_6075	COG0644	oxidoreductase
AM1_6085	COG2909	trisaccharide binding
AM1_6086	COG2909	trisaccharide binding
AM1_6096	COG1309	transcriptional regulator
AM1_6103	COG0135	phosphoribosylanthranilate isomerase activity
AM1_6106	COG4977	sequence-specific DNA binding
AM1_6125	COG0582	viral genome integration into host DNA
AM1_6127	COG0582	viral genome integration into host DNA
AM1_6133	COG0534	Mate efflux family protein
AM1_6134	COG0783	Belongs to the Dps family
AM1_6138	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_6141	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_6143	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_6148	COG0475	glutathione-regulated potassium exporter activity
AM1_6151	COG1484	DNA-dependent DNA replication
AM1_6152	COG4584	PFAM Integrase catalytic
AM1_6171	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_6173	COG0776	regulation of translation
AM1_6179	COG4227	nucleotidyltransferase activity
AM1_6182	COG4974	Belongs to the 'phage' integrase family
AM1_6196	COG3063	Type IV pilus biogenesis stability protein PilW
AM1_6199	COG3706	GGDEF domain
AM1_6199	COG5001	Diguanylate cyclase
AM1_6199	COG4251	negative regulation of phosphorylation
AM1_6199	COG2203	Gaf domain
AM1_6202	COG0582	viral genome integration into host DNA
AM1_6208	COG1252	NADH dehydrogenase
AM1_6209	COG4221	oxidoreductase activity
AM1_6214	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
AM1_6220	COG2319	Wd-40 repeat
AM1_6220	COG3903	Transcriptional regulator
AM1_6223	COG3903	Transcriptional regulator
AM1_6223	COG2319	Wd-40 repeat
AM1_6232	COG1917	Cupin 2, conserved barrel domain protein
AM1_6232	COG4977	sequence-specific DNA binding
AM1_6237	COG4584	PFAM Integrase catalytic
AM1_6238	COG1484	DNA-dependent DNA replication
AM1_6240	COG3328	transposase activity
AM1_6263	COG0698	ribose 5-phosphate isomerase
AM1_6281	COG1309	transcriptional regulator
AM1_6282	COG4585	Histidine kinase
AM1_6292	COG0515	serine threonine protein kinase
AM1_6300	COG0640	Transcriptional regulator
AM1_6308	COG2197	response regulator
AM1_6313	COG2197	response regulator
AM1_6314	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM1_6314	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM1_6316	COG4977	sequence-specific DNA binding
AM1_6316	COG1917	Cupin 2, conserved barrel domain protein
AM1_6318	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AM1_6319	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AM1_6320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AM1_6321	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AM1_6328	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_6330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_6332	COG0745	RESPONSE REGULATOR receiver
AM1_6333	COG2205	protein histidine kinase activity
AM1_6333	COG3850	Histidine kinase
AM1_6333	COG3437	response regulator, receiver
AM1_6333	COG4999	Histidine kinase
AM1_6334	COG0589	response to stress
AM1_6335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM1_6336	COG0589	response to stress
AM1_6345	COG0697	spore germination
AM1_6346	COG0189	ligase activity
AM1_6351	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AM1_6355	COG0493	'glutamate synthase
AM1_6358	COG5002	protein histidine kinase activity
AM1_6358	COG2198	Histidine kinase
AM1_6358	COG0784	Response regulator, receiver
AM1_6359	COG2205	protein histidine kinase activity
AM1_6359	COG0784	Response regulator, receiver
AM1_6361	COG0683	leucine binding
AM1_6362	COG0306	phosphate transporter
AM1_6363	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_6365	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_6365	COG0515	serine threonine protein kinase
AM1_6366	COG0070	glutamate synthase
AM1_6366	COG0069	glutamate synthase activity
AM1_6366	COG0067	glutamate synthase
AM1_6370	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AM1_6372	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_6373	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM1_6374	COG5002	protein histidine kinase activity
AM1_6375	COG3659	wide pore channel activity
AM1_6376	COG0588	phosphoglycerate mutase activity
AM1_6378	COG0667	Aldo Keto reductase
AM1_6381	COG1132	(ABC) transporter
AM1_6383	COG1819	glycosyl
AM1_6387	COG0745	RESPONSE REGULATOR receiver
AM1_6388	COG1254	Belongs to the acylphosphatase family
AM1_6391	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AM1_6422	COG0528	UMP kinase activity
AM1_A0014	COG1484	DNA-dependent DNA replication
AM1_A0015	COG4584	PFAM Integrase catalytic
AM1_A0017	COG0270	DNA (cytosine-5-)-methyltransferase activity
AM1_A0018	COG4191	Histidine kinase
AM1_A0022	COG0739	heme binding
AM1_A0041	COG2226	methyltransferase
AM1_A0047	COG0668	transmembrane transport
AM1_A0051	COG0724	RNA recognition motif
AM1_A0054	COG1309	transcriptional regulator
AM1_A0071	COG0724	RNA recognition motif
AM1_A0079	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_A0090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM1_A0091	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_A0092	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM1_A0096	COG0724	RNA recognition motif
AM1_A0114	COG5001	Diguanylate cyclase
AM1_A0114	COG1716	ATPase activity
AM1_A0119	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_A0120	COG4221	oxidoreductase activity
AM1_A0125	COG1169	isochorismate synthase
AM1_A0127	COG1902	pentaerythritol trinitrate reductase activity
AM1_A0134	COG3744	PilT protein domain protein
AM1_A0135	COG0582	viral genome integration into host DNA
AM1_A0147	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AM1_A0150	COG0783	Belongs to the Dps family
AM1_A0153	COG0390	transport system, permease component
AM1_A0154	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM1_A0156	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_A0161	COG1120	ATPase activity
AM1_A0162	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM1_A0163	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM1_A0164	COG0848	biopolymer transport protein
AM1_A0165	COG0811	peptide transport
AM1_A0170	COG4771	TonB-dependent receptor
AM1_A0171	COG2223	nitrite transmembrane transporter activity
AM1_A0173	COG1132	(ABC) transporter
AM1_A0182	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_A0185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AM1_A0202	COG2119	membrane
AM1_A0215	COG1484	DNA-dependent DNA replication
AM1_A0226	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AM1_A0230	COG3433	isochorismatase activity
AM1_A0230	COG2226	methyltransferase
AM1_A0230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM1_A0234	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM1_A0237	COG2226	methyltransferase
AM1_A0251	COG1192	Involved in chromosome partitioning
AM1_A0252	COG1475	DNA binding
AM1_A0258	COG0582	viral genome integration into host DNA
AM1_A0259	COG1484	DNA-dependent DNA replication
AM1_A0260	COG4584	PFAM Integrase catalytic
AM1_A0261	COG0582	viral genome integration into host DNA
AM1_A0268	COG0735	belongs to the Fur family
AM1_A0269	COG2119	membrane
AM1_A0273	COG2814	Major facilitator Superfamily
AM1_A0274	COG4774	siderophore transport
AM1_A0277	COG0288	reversible hydration of carbon dioxide
AM1_A0289	COG2994	toxin metabolic process
AM1_A0296	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AM1_A0296	COG1024	Enoyl-CoA hydratase
AM1_A0298	COG3903	Transcriptional regulator
AM1_A0298	COG2319	Wd-40 repeat
AM1_A0300	COG0450	alkyl hydroperoxide reductase
AM1_A0302	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM1_A0303	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM1_A0313	COG1475	DNA binding
AM1_A0320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_A0329	COG0270	DNA (cytosine-5-)-methyltransferase activity
AM1_A0353	COG0776	regulation of translation
AM1_A0354	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_A0368	COG3706	GGDEF domain
AM1_A0368	COG0745	RESPONSE REGULATOR receiver
AM1_A0375	COG3328	transposase activity
AM1_A0387	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_B0002	COG1484	DNA-dependent DNA replication
AM1_B0003	COG4584	PFAM Integrase catalytic
AM1_B0006	COG1484	DNA-dependent DNA replication
AM1_B0012	COG4584	PFAM Integrase catalytic
AM1_B0013	COG1484	DNA-dependent DNA replication
AM1_B0027	COG1192	Involved in chromosome partitioning
AM1_B0028	COG1475	DNA binding
AM1_B0062	COG1960	acyl-CoA dehydrogenase activity
AM1_B0086	COG0776	regulation of translation
AM1_B0087	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_B0103	COG0456	acetyltransferase
AM1_B0112	COG0523	cobalamin synthesis protein
AM1_B0119	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM1_B0121	COG0848	biopolymer transport protein
AM1_B0122	COG0811	peptide transport
AM1_B0123	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM1_B0124	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM1_B0133	COG0625	glutathione transferase activity
AM1_B0135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM1_B0142	COG0735	belongs to the Fur family
AM1_B0146	COG0523	cobalamin synthesis protein
AM1_B0148	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM1_B0155	COG0640	Transcriptional regulator
AM1_B0161	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM1_B0166	COG0215	cysteine-tRNA ligase activity
AM1_B0169	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AM1_B0173	COG0302	gtp cyclohydrolase
AM1_B0175	COG4942	peptidase
AM1_B0179	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AM1_B0187	COG4974	Belongs to the 'phage' integrase family
AM1_B0194	COG0582	viral genome integration into host DNA
AM1_B0197	COG0572	uridine kinase
AM1_B0206	COG3328	transposase activity
AM1_B0264	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_B0264	COG0515	serine threonine protein kinase
AM1_B0265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_B0265	COG0515	serine threonine protein kinase
AM1_B0266	COG0515	serine threonine protein kinase
AM1_B0266	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_B0270	COG0515	serine threonine protein kinase
AM1_B0270	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_B0277	COG0739	heme binding
AM1_B0294	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_B0298	COG2815	serine threonine protein kinase
AM1_B0298	COG0515	serine threonine protein kinase
AM1_B0302	COG2124	cytochrome p450
AM1_B0303	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_B0307	COG2319	Wd-40 repeat
AM1_B0307	COG3903	Transcriptional regulator
AM1_B0311	COG1525	nuclease
AM1_B0315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM1_B0319	COG2319	Wd-40 repeat
AM1_B0319	COG5635	Nacht domain
AM1_B0320	COG0582	viral genome integration into host DNA
AM1_B0331	COG4974	Belongs to the 'phage' integrase family
AM1_B0364	COG1525	nuclease
AM1_B0365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_B0374	COG3093	addiction module antidote protein HigA
AM1_B0378	COG1484	DNA-dependent DNA replication
AM1_B0379	COG4584	PFAM Integrase catalytic
AM1_B0381	COG3547	Transposase (IS116 IS110 IS902 family)
AM1_B0389	COG3903	Transcriptional regulator
AM1_B0389	COG2319	Wd-40 repeat
AM1_B0400	COG3547	Transposase (IS116 IS110 IS902 family)
AM1_B0403	COG1662	PFAM IS1 transposase
AM1_B0409	COG1799	cell septum assembly
AM1_B0411	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM1_B0413	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM1_C0016	COG4585	Histidine kinase
AM1_C0017	COG2197	response regulator
AM1_C0018	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM1_C0023	COG2198	Histidine kinase
AM1_C0023	COG5002	protein histidine kinase activity
AM1_C0023	COG0784	Response regulator, receiver
AM1_C0028	COG4942	peptidase
AM1_C0048	COG0724	RNA recognition motif
AM1_C0050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM1_C0052	COG0583	DNA-binding transcription factor activity
AM1_C0055	COG0583	DNA-binding transcription factor activity
AM1_C0066	COG1484	DNA-dependent DNA replication
AM1_C0067	COG4584	PFAM Integrase catalytic
AM1_C0074	COG0724	RNA recognition motif
AM1_C0077	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM1_C0078	COG4584	PFAM Integrase catalytic
AM1_C0079	COG1484	DNA-dependent DNA replication
AM1_C0085	COG2045	Belongs to the ComB family
AM1_C0086	COG0745	RESPONSE REGULATOR receiver
AM1_C0092	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AM1_C0102	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AM1_C0108	COG5398	heme oxygenase
AM1_C0134	COG0582	viral genome integration into host DNA
AM1_C0178	COG1012	belongs to the aldehyde dehydrogenase family
AM1_C0193	COG0745	RESPONSE REGULATOR receiver
AM1_C0203	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AM1_C0205	COG5398	heme oxygenase
AM1_C0262	COG0596	Alpha beta hydrolase
AM1_C0272	COG1413	lyase activity
AM1_C0287	COG1192	Involved in chromosome partitioning
AM1_C0288	COG1475	DNA binding
AM1_C0293	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AM1_C0295	COG1216	Glycosyl transferase, family 2
AM1_C0304	COG0745	RESPONSE REGULATOR receiver
AM1_C0305	COG5002	protein histidine kinase activity
AM1_C0338	COG0776	regulation of translation
AM1_C0339	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_C0344	COG2318	DinB family
AM1_C0353	COG0776	regulation of translation
AM1_C0360	COG0776	regulation of translation
AM1_C0365	COG3706	GGDEF domain
AM1_C0365	COG0745	RESPONSE REGULATOR receiver
AM1_D0001	COG0724	RNA recognition motif
AM1_D0011	COG0745	RESPONSE REGULATOR receiver
AM1_D0013	COG1799	cell septum assembly
AM1_D0029	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_D0031	COG0739	heme binding
AM1_D0056	COG1484	DNA-dependent DNA replication
AM1_D0076	COG1662	PFAM IS1 transposase
AM1_D0085	COG0322	excinuclease ABC activity
AM1_D0087	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AM1_D0089	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_D0103	COG3657	addiction module killer protein
AM1_D0123	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_D0128	COG1192	Involved in chromosome partitioning
AM1_D0137	COG3316	Transposase and inactivated derivatives
AM1_D0138	COG1555	photosystem II stabilization
AM1_D0143	COG0205	6-phosphofructokinase activity
AM1_D0144	COG0409	Hydrogenase expression formation protein
AM1_D0147	COG0071	Belongs to the small heat shock protein (HSP20) family
AM1_D0149	COG1136	(ABC) transporter
AM1_D0156	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM1_D0156	COG0574	Belongs to the PEP-utilizing enzyme family
AM1_D0160	COG0475	glutathione-regulated potassium exporter activity
AM1_D0164	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AM1_D0167	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AM1_D0172	COG0726	polysaccharide deacetylase
AM1_D0173	COG0589	response to stress
AM1_D0175	COG0589	response to stress
AM1_D0182	COG1034	ATP synthesis coupled electron transport
AM1_D0183	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM1_D0184	COG0517	IMP dehydrogenase activity
AM1_D0187	COG3259	Nickel-dependent hydrogenase
AM1_D0188	COG0298	carbon dioxide binding
AM1_D0189	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AM1_D0192	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AM1_D0193	COG0375	protein maturation
AM1_D0197	COG0309	Hydrogenase expression formation protein (HypE)
AM1_D0200	COG0058	SHG alpha-glucan phosphorylase activity
AM1_D0201	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_D0204	COG1063	alcohol dehydrogenase
AM1_D0207	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AM1_D0219	COG4974	Belongs to the 'phage' integrase family
AM1_D0228	COG4584	PFAM Integrase catalytic
AM1_D0229	COG1484	DNA-dependent DNA replication
AM1_D0234	COG0589	response to stress
AM1_D0238	COG0702	epimerase
AM1_D0243	COG2226	methyltransferase
AM1_D0245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM1_D0256	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM1_D0260	COG0582	viral genome integration into host DNA
AM1_D0265	COG1902	pentaerythritol trinitrate reductase activity
AM1_D0271	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AM1_D0273	COG0724	RNA recognition motif
AM1_E0014	COG0582	viral genome integration into host DNA
AM1_E0025	COG0582	viral genome integration into host DNA
AM1_E0077	COG4584	PFAM Integrase catalytic
AM1_E0078	COG1484	DNA-dependent DNA replication
AM1_E0080	COG1484	DNA-dependent DNA replication
AM1_E0091	COG1192	Involved in chromosome partitioning
AM1_E0095	COG0557	exoribonuclease II activity
AM1_E0100	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_E0103	COG1733	regulation of RNA biosynthetic process
AM1_E0109	COG2319	Wd-40 repeat
AM1_E0109	COG3903	Transcriptional regulator
AM1_E0111	COG4974	Belongs to the 'phage' integrase family
AM1_E0123	COG3214	Protein conserved in bacteria
AM1_E0127	COG0557	exoribonuclease II activity
AM1_E0175	COG1484	DNA-dependent DNA replication
AM1_E0176	COG4584	PFAM Integrase catalytic
AM1_E0211	COG0739	heme binding
AM1_E0213	COG1595	DNA-templated transcription, initiation
AM1_E0215	COG2161	toxin-antitoxin pair type II binding
AM1_E0220	COG4804	nuclease activity
AM1_F0012	COG2340	Cysteine-rich secretory protein family
AM1_F0034	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM1_F0036	COG1192	Involved in chromosome partitioning
AM1_F0038	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AM1_F0041	COG5002	protein histidine kinase activity
AM1_F0042	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM1_F0044	COG0583	DNA-binding transcription factor activity
AM1_F0055	COG0640	Transcriptional regulator
AM1_F0057	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM1_F0059	COG5433	transposase activity
AM1_F0070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AM1_F0072	COG0523	cobalamin synthesis protein
AM1_F0075	COG0735	belongs to the Fur family
AM1_F0077	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AM1_F0088	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_F0088	COG0515	serine threonine protein kinase
AM1_F0097	COG1902	pentaerythritol trinitrate reductase activity
AM1_F0100	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM1_F0101	COG0501	Belongs to the peptidase M48B family
AM1_F0113	COG0745	RESPONSE REGULATOR receiver
AM1_F0127	COG2815	serine threonine protein kinase
AM1_F0127	COG0515	serine threonine protein kinase
AM1_F0128	COG2319	Wd-40 repeat
AM1_F0128	COG3903	Transcriptional regulator
AM1_F0151	COG4584	PFAM Integrase catalytic
AM1_F0152	COG1484	DNA-dependent DNA replication
AM1_F0170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM1_F0176	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_G0010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM1_G0011	COG2319	Wd-40 repeat
AM1_G0021	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_G0022	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_G0023	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM1_G0028	COG1192	Involved in chromosome partitioning
AM1_G0038	COG3316	Transposase and inactivated derivatives
AM1_G0041	COG0004	ammonium transporteR
AM1_G0047	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM1_G0054	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_G0075	COG0739	heme binding
AM1_G0080	COG1028	Short-chain dehydrogenase reductase Sdr
AM1_G0084	COG0300	oxidoreductase activity
AM1_G0085	COG0300	oxidoreductase activity
AM1_G0098	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM1_G0111	COG0515	serine threonine protein kinase
AM1_G0111	COG1357	PFAM Pentapeptide repeats (8 copies)
AM1_G0114	COG1555	photosystem II stabilization
AM1_G0115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM1_G0118	COG4584	PFAM Integrase catalytic
AM1_G0119	COG1484	DNA-dependent DNA replication
AM1_G0129	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM1_G0153	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AM1_G0162	COG2319	Wd-40 repeat
AM1_G0162	COG4249	Peptidase C14 caspase catalytic subunit p20
AM1_G0162	COG2319	Wd-40 repeat
AM1_G0162	COG4249	Peptidase C14 caspase catalytic subunit p20
AM1_G0164	COG2319	Wd-40 repeat
AM1_G0164	COG3903	Transcriptional regulator
AM1_H0001	COG4584	PFAM Integrase catalytic
AM1_H0002	COG1484	DNA-dependent DNA replication
AM1_H0057	COG3063	Type IV pilus biogenesis stability protein PilW
AM1_H0058	COG4251	negative regulation of phosphorylation
AM1_H0058	COG2203	Gaf domain
AM1_H0058	COG5001	Diguanylate cyclase
AM1_H0058	COG3706	GGDEF domain
AM1_H0059	COG4974	Belongs to the 'phage' integrase family
AM1_H0060	COG2319	Wd-40 repeat
AM1_H0060	COG4249	Peptidase C14 caspase catalytic subunit p20
AM1_H0064	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM1_H0068	COG4581	dead DEAH box helicase
AM1_H0072	COG1192	Involved in chromosome partitioning
AM1_H0074	COG4584	PFAM Integrase catalytic
AM1_H0075	COG1484	DNA-dependent DNA replication
AM1_H0091	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AM1_H0106	COG0739	heme binding