locus-tag	class	description
I1H34_00010	COG1247	-acetyltransferase
I1H34_00045	COG1876	peptidase activity
I1H34_00060	COG0259	pyridoxamine-phosphate oxidase activity
I1H34_00065	COG0534	Mate efflux family protein
I1H34_00080	COG3344	reverse transcriptase
I1H34_00085	COG0583	DNA-binding transcription factor activity
I1H34_00105	COG2267	carboxylic ester hydrolase activity
I1H34_00260	COG0745	RESPONSE REGULATOR receiver
I1H34_00265	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I1H34_00270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1H34_00280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1H34_00285	COG0484	heat shock protein binding
I1H34_00320	COG0724	RNA recognition motif
I1H34_00365	COG1595	DNA-templated transcription, initiation
I1H34_00420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_00445	COG1475	DNA binding
I1H34_00455	COG0572	uridine kinase
I1H34_00485	COG1077	Cell shape determining protein MreB Mrl
I1H34_00510	COG0189	ligase activity
I1H34_00510	COG4067	protein conserved in archaea
I1H34_00550	COG0475	glutathione-regulated potassium exporter activity
I1H34_00550	COG0589	response to stress
I1H34_00570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_00575	COG5002	protein histidine kinase activity
I1H34_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1H34_00585	COG0784	Response regulator, receiver
I1H34_00585	COG2205	protein histidine kinase activity
I1H34_00590	COG2197	response regulator
I1H34_00625	COG0726	polysaccharide deacetylase
I1H34_00640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I1H34_00655	COG3093	addiction module antidote protein HigA
I1H34_00790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1H34_00870	COG0251	oxidation-reduction process
I1H34_00880	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I1H34_00880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1H34_00910	COG0028	Belongs to the TPP enzyme family
I1H34_00920	COG0583	DNA-binding transcription factor activity
I1H34_00925	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I1H34_00940	COG0469	pyruvate kinase activity
I1H34_00945	COG1959	2 iron, 2 sulfur cluster binding
I1H34_00990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I1H34_00995	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I1H34_01005	COG5002	protein histidine kinase activity
I1H34_01005	COG5001	Diguanylate cyclase
I1H34_01010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1H34_01020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1H34_01025	COG0649	NAD binding
I1H34_01045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1H34_01065	COG1063	alcohol dehydrogenase
I1H34_01090	COG0346	lactoylglutathione lyase activity
I1H34_01115	COG0625	glutathione transferase activity
I1H34_01120	COG1902	pentaerythritol trinitrate reductase activity
I1H34_01135	COG4221	oxidoreductase activity
I1H34_01140	COG1064	alcohol dehydrogenase
I1H34_01145	COG0515	serine threonine protein kinase
I1H34_01150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1H34_01165	COG2211	Major facilitator Superfamily
I1H34_01170	COG1722	exodeoxyribonuclease VII activity
I1H34_01175	COG1570	exodeoxyribonuclease VII activity
I1H34_01180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1H34_01185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I1H34_01205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1H34_01220	COG1120	ATPase activity
I1H34_01225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1H34_01230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1H34_01255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1H34_01265	COG0492	ferredoxin-NADP+ reductase activity
I1H34_01325	COG3588	fructose-bisphosphate aldolase
I1H34_01340	COG3128	pkhd-type hydroxylase
I1H34_01365	COG2207	Transcriptional regulator
I1H34_01370	COG4771	TonB-dependent receptor
I1H34_01395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1H34_01410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1H34_01475	COG0783	Belongs to the Dps family
I1H34_01480	COG0848	biopolymer transport protein
I1H34_01485	COG0811	peptide transport
I1H34_01495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I1H34_01500	COG1120	ATPase activity
I1H34_01505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I1H34_01520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_01560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I1H34_01565	COG0052	Belongs to the universal ribosomal protein uS2 family
I1H34_01570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I1H34_01590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1H34_01595	COG0768	penicillin binding
I1H34_01600	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I1H34_01630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I1H34_01635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I1H34_01640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I1H34_01645	COG0544	peptidyl-prolyl cis-trans isomerase activity
I1H34_01650	COG0740	serine-type endopeptidase activity
I1H34_01655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I1H34_01660	COG2267	carboxylic ester hydrolase activity
I1H34_01665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I1H34_01675	COG5001	Diguanylate cyclase
I1H34_01675	COG5002	protein histidine kinase activity
I1H34_01680	COG1193	negative regulation of DNA recombination
I1H34_01695	COG0288	reversible hydration of carbon dioxide
I1H34_01730	COG5002	protein histidine kinase activity
I1H34_01735	COG0745	RESPONSE REGULATOR receiver
I1H34_01765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1H34_01770	COG0581	inorganic phosphate transmembrane transporter activity
I1H34_01775	COG0573	inorganic phosphate transmembrane transporter activity
I1H34_01785	COG0640	Transcriptional regulator
I1H34_01810	COG4249	Peptidase C14 caspase catalytic subunit p20
I1H34_01810	COG2319	Wd-40 repeat
I1H34_01835	COG1748	Saccharopine dehydrogenase
I1H34_01840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1H34_01850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I1H34_01865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I1H34_01870	COG0204	Acyl-transferase
I1H34_01870	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_01880	COG0242	peptide deformylase activity
I1H34_01910	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I1H34_01915	COG0010	Belongs to the arginase family
I1H34_01925	COG0154	amidase activity
I1H34_01935	COG0004	ammonium transporteR
I1H34_01940	COG0004	ammonium transporteR
I1H34_01990	COG2385	sporulation resulting in formation of a cellular spore
I1H34_02020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I1H34_02025	COG3540	Alkaline phosphatase
I1H34_02045	COG4221	oxidoreductase activity
I1H34_02080	COG2124	cytochrome p450
I1H34_02085	COG0753	catalase activity
I1H34_02090	COG0515	serine threonine protein kinase
I1H34_02090	COG2815	serine threonine protein kinase
I1H34_02095	COG2204	response regulator
I1H34_02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1H34_02100	COG4191	Histidine kinase
I1H34_02105	COG0784	Response regulator, receiver
I1H34_02105	COG3437	response regulator, receiver
I1H34_02110	COG2203	Gaf domain
I1H34_02110	COG5001	Diguanylate cyclase
I1H34_02110	COG3706	GGDEF domain
I1H34_02110	COG4251	negative regulation of phosphorylation
I1H34_02115	COG0116	Belongs to the methyltransferase superfamily
I1H34_02120	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1H34_02130	COG0822	iron-sulfur transferase activity
I1H34_02140	COG0371	Dehydrogenase
I1H34_02145	COG0436	Aminotransferase
I1H34_02150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I1H34_02155	COG0569	domain protein
I1H34_02160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I1H34_02170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I1H34_02175	COG0406	alpha-ribazole phosphatase activity
I1H34_02205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1H34_02210	COG0268	Binds directly to 16S ribosomal RNA
I1H34_02215	COG0084	hydrolase, TatD family'
I1H34_02220	COG0085	RNA polymerase activity
I1H34_02225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1H34_02230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I1H34_02235	COG2267	carboxylic ester hydrolase activity
I1H34_02240	COG0534	Mate efflux family protein
I1H34_02255	COG2022	thiamine diphosphate biosynthetic process
I1H34_02260	COG1595	DNA-templated transcription, initiation
I1H34_02270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1H34_02325	COG2226	methyltransferase
I1H34_02340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1H34_02380	COG0673	inositol 2-dehydrogenase activity
I1H34_02415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I1H34_02420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I1H34_02425	COG0799	negative regulation of ribosome biogenesis
I1H34_02445	COG0628	permease
I1H34_02460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1H34_02480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1H34_02485	COG1215	transferase activity, transferring glycosyl groups
I1H34_02495	COG3769	mannosylglycerate metabolic process
I1H34_02505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I1H34_02525	COG2045	Belongs to the ComB family
I1H34_02530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1H34_02560	COG2082	Precorrin-8x methylmutase
I1H34_02575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I1H34_02585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I1H34_02600	COG0483	inositol monophosphate 1-phosphatase activity
I1H34_02610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1H34_02620	COG0300	oxidoreductase activity
I1H34_02635	COG0735	belongs to the Fur family
I1H34_02640	COG0678	peroxiredoxin activity
I1H34_02645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1H34_02655	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1H34_02700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1H34_02700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I1H34_02715	COG0343	queuine tRNA-ribosyltransferase activity
I1H34_02725	COG0701	Predicted permease
I1H34_02735	COG2198	Histidine kinase
I1H34_02735	COG0784	Response regulator, receiver
I1H34_02735	COG2205	protein histidine kinase activity
I1H34_02740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I1H34_02745	COG2197	response regulator
I1H34_02760	COG3263	regulation of cellular component size
I1H34_02790	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I1H34_02800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1H34_02815	COG0667	Aldo Keto reductase
I1H34_02820	COG3903	Transcriptional regulator
I1H34_02820	COG2319	Wd-40 repeat
I1H34_02845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I1H34_02865	COG3128	pkhd-type hydroxylase
I1H34_02880	COG3706	GGDEF domain
I1H34_02880	COG4251	negative regulation of phosphorylation
I1H34_02880	COG5001	Diguanylate cyclase
I1H34_02880	COG2203	Gaf domain
I1H34_02900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I1H34_02905	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_02925	COG0667	Aldo Keto reductase
I1H34_02945	COG0589	response to stress
I1H34_02950	COG0659	secondary active sulfate transmembrane transporter activity
I1H34_02955	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I1H34_02960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1H34_02960	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I1H34_02980	COG0842	Transport permease protein
I1H34_02980	COG1131	(ABC) transporter
I1H34_02980	COG1716	ATPase activity
I1H34_02985	COG0515	serine threonine protein kinase
I1H34_02985	COG3266	domain, Protein
I1H34_02990	COG0745	RESPONSE REGULATOR receiver
I1H34_03005	COG0861	Integral membrane protein TerC family
I1H34_03015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1H34_03035	COG1598	PFAM Uncharacterised protein family UPF0150
I1H34_03065	COG0105	UTP biosynthetic process
I1H34_03070	COG0671	phosphoesterase, PA-phosphatase related
I1H34_03100	COG2198	Histidine kinase
I1H34_03100	COG0784	Response regulator, receiver
I1H34_03100	COG0643	Histidine kinase
I1H34_03105	COG0840	transmembrane signaling receptor activity
I1H34_03105	COG2203	Gaf domain
I1H34_03120	COG0784	Response regulator, receiver
I1H34_03130	COG5002	protein histidine kinase activity
I1H34_03130	COG2205	protein histidine kinase activity
I1H34_03130	COG0784	Response regulator, receiver
I1H34_03135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1H34_03145	COG1876	peptidase activity
I1H34_03150	COG0515	serine threonine protein kinase
I1H34_03150	COG3266	domain, Protein
I1H34_03155	COG4948	Mandelate Racemase Muconate Lactonizing
I1H34_03160	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_03180	COG1396	sequence-specific DNA binding
I1H34_03190	COG3239	Fatty acid desaturase
I1H34_03270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1H34_03280	COG1132	(ABC) transporter
I1H34_03310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1H34_03315	COG0552	protein localization to endoplasmic reticulum
I1H34_03320	COG2208	phosphoserine phosphatase activity
I1H34_03330	COG0006	proline dipeptidase activity
I1H34_03365	COG0730	response to heat
I1H34_03375	COG0308	aminopeptidase N
I1H34_03420	COG0432	Pfam Uncharacterised protein family UPF0047
I1H34_03450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1H34_03465	COG1940	carbohydrate kinase activity
I1H34_03500	COG0521	Mo-molybdopterin cofactor biosynthetic process
I1H34_03510	COG2161	toxin-antitoxin pair type II binding
I1H34_03515	COG2226	methyltransferase
I1H34_03540	COG1201	RNA secondary structure unwinding
I1H34_03545	COG4251	negative regulation of phosphorylation
I1H34_03550	COG4251	negative regulation of phosphorylation
I1H34_03555	COG0745	RESPONSE REGULATOR receiver
I1H34_03560	COG5002	protein histidine kinase activity
I1H34_03560	COG5001	Diguanylate cyclase
I1H34_03565	COG0484	heat shock protein binding
I1H34_03575	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_03580	COG2081	HI0933 family
I1H34_03585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I1H34_03595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I1H34_03605	COG2010	Cytochrome c
I1H34_03610	COG2010	Cytochrome c
I1H34_03615	COG2010	Cytochrome c
I1H34_03630	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_03640	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
I1H34_03650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1H34_03690	COG3335	DDE superfamily endonuclease
I1H34_03710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I1H34_03730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I1H34_03740	COG4115	mRNA cleavage
I1H34_03775	COG0515	serine threonine protein kinase
I1H34_03775	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_03790	COG0745	RESPONSE REGULATOR receiver
I1H34_03795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I1H34_03800	COG1194	a g-specific adenine glycosylase
I1H34_03815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_03820	COG2091	lysine biosynthetic process via aminoadipic acid
I1H34_03825	COG0426	domain, Protein
I1H34_03825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1H34_03850	COG0511	ligase activity, forming carbon-carbon bonds
I1H34_03855	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I1H34_03865	COG0745	RESPONSE REGULATOR receiver
I1H34_03870	COG3932	Exopolysaccharide synthesis, ExoD
I1H34_03875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I1H34_03895	COG0181	hydroxymethylbilane synthase activity
I1H34_03905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1H34_03910	COG0205	6-phosphofructokinase activity
I1H34_03915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1H34_03935	COG2319	Wd-40 repeat
I1H34_03935	COG3903	Transcriptional regulator
I1H34_03950	COG0792	nuclease activity
I1H34_03960	COG0747	negative chemotaxis
I1H34_03965	COG0633	Ferredoxin
I1H34_04000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1H34_04005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I1H34_04010	COG1555	photosystem II stabilization
I1H34_04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1H34_04035	COG0330	HflC and HflK could
I1H34_04065	COG0148	phosphopyruvate hydratase activity
I1H34_04070	COG0346	lactoylglutathione lyase activity
I1H34_04075	COG3659	wide pore channel activity
I1H34_04080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I1H34_04085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I1H34_04090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I1H34_04105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1H34_04110	COG0483	inositol monophosphate 1-phosphatase activity
I1H34_04115	COG0484	heat shock protein binding
I1H34_04120	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I1H34_04125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I1H34_04150	COG0436	Aminotransferase
I1H34_04155	COG1842	Phage shock protein A
I1H34_04165	COG0667	Aldo Keto reductase
I1H34_04170	COG0372	Belongs to the citrate synthase family
I1H34_04220	COG0596	Alpha beta hydrolase
I1H34_04240	COG0384	phenazine biosynthesis protein PhzF
I1H34_04260	COG0604	alcohol dehydrogenase
I1H34_04260	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_04260	COG3321	synthase
I1H34_04310	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
I1H34_04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1H34_04325	COG0515	serine threonine protein kinase
I1H34_04345	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1H34_04350	COG5322	oxidoreductase activity
I1H34_04385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I1H34_04395	COG0745	RESPONSE REGULATOR receiver
I1H34_04400	COG4581	dead DEAH box helicase
I1H34_04405	COG0643	Histidine kinase
I1H34_04405	COG2198	Histidine kinase
I1H34_04410	COG0840	transmembrane signaling receptor activity
I1H34_04430	COG1573	uracil-dna glycosylase
I1H34_04445	COG0750	zinc metalloprotease
I1H34_04450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I1H34_04455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I1H34_04470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I1H34_04475	COG0215	cysteine-tRNA ligase activity
I1H34_04485	COG5001	Diguanylate cyclase
I1H34_04485	COG1716	ATPase activity
I1H34_04495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_04535	COG2855	membrane
I1H34_04555	COG3265	gluconokinase activity
I1H34_04560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1H34_04565	COG1121	(ABC) transporter
I1H34_04570	COG0228	four-way junction DNA binding
I1H34_04575	COG1837	Belongs to the UPF0109 family
I1H34_04580	COG1702	phosphate starvation-inducible protein PhoH
I1H34_04595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I1H34_04600	COG0336	Belongs to the RNA methyltransferase TrmD family
I1H34_04605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I1H34_04630	COG0702	epimerase
I1H34_04645	COG2183	response to ionizing radiation
I1H34_04670	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I1H34_04710	COG0006	proline dipeptidase activity
I1H34_04715	COG0438	transferase activity, transferring glycosyl groups
I1H34_04720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I1H34_04725	COG0456	acetyltransferase
I1H34_04730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I1H34_04750	COG0697	spore germination
I1H34_04770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I1H34_04780	COG1285	pathogenesis
I1H34_04785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1H34_04820	COG0583	DNA-binding transcription factor activity
I1H34_04865	COG0347	Belongs to the P(II) protein family
I1H34_04880	COG0697	spore germination
I1H34_04925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I1H34_04935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1H34_04935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1H34_04950	COG1672	PFAM Archaeal ATPase
I1H34_04950	COG2319	Wd-40 repeat
I1H34_04985	COG0252	asparaginase activity
I1H34_05010	COG2255	four-way junction helicase activity
I1H34_05015	COG1690	Belongs to the RtcB family
I1H34_05020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1H34_05030	COG0670	Belongs to the BI1 family
I1H34_05040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I1H34_05045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I1H34_05055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_05075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1H34_05080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I1H34_05085	COG1104	cysteine desulfurase activity
I1H34_05130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I1H34_05145	COG1214	PFAM Peptidase M22, glycoprotease
I1H34_05150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1H34_05160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I1H34_05165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I1H34_05165	COG0519	Catalyzes the synthesis of GMP from XMP
I1H34_05175	COG2205	protein histidine kinase activity
I1H34_05175	COG2202	Pas domain
I1H34_05220	COG0534	Mate efflux family protein
I1H34_05230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I1H34_05260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1H34_05270	COG1132	(ABC) transporter
I1H34_05280	COG3258	Cytochrome c
I1H34_05295	COG0805	protein transport
I1H34_05300	COG2259	Doxx family
I1H34_05325	COG0793	Belongs to the peptidase S41A family
I1H34_05330	COG1346	cytolysis
I1H34_05335	COG1380	Effector of murein hydrolase LrgA
I1H34_05340	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I1H34_05405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I1H34_05440	COG0745	RESPONSE REGULATOR receiver
I1H34_05445	COG1672	PFAM Archaeal ATPase
I1H34_05445	COG2319	Wd-40 repeat
I1H34_05450	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_05500	COG0519	Catalyzes the synthesis of GMP from XMP
I1H34_05520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I1H34_05525	COG0187	DNA topoisomerase II activity
I1H34_05525	COG1372	Participates in initiation and elongation during chromosome replication
I1H34_05535	COG0170	dolichyl monophosphate biosynthetic process
I1H34_05550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I1H34_05555	COG0023	Translation Initiation Factor
I1H34_05590	COG0788	formyltetrahydrofolate deformylase activity
I1H34_05615	COG1070	Carbohydrate kinase
I1H34_05650	COG0395	ABC-type sugar transport system, permease component
I1H34_05660	COG0165	Argininosuccinate lyase
I1H34_05670	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I1H34_05675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1H34_05680	COG0459	protein refolding
I1H34_05715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1H34_05715	COG1333	cytochrome c biogenesis protein
I1H34_05760	COG0739	heme binding
I1H34_05760	COG1196	nuclear chromosome segregation
I1H34_05760	COG0741	lytic transglycosylase activity
I1H34_05765	COG1132	(ABC) transporter
I1H34_05775	COG0149	triose-phosphate isomerase activity
I1H34_05780	COG0583	DNA-binding transcription factor activity
I1H34_05785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1H34_05790	COG0746	molybdenum cofactor guanylyltransferase activity
I1H34_05810	COG0531	amino acid
I1H34_05825	COG0210	DNA helicase
I1H34_05835	COG1304	FMN binding
I1H34_05840	COG3264	Mechanosensitive ion channel
I1H34_05840	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I1H34_05855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1H34_05860	COG2003	Belongs to the UPF0758 family
I1H34_05865	COG0284	orotidine-5'-phosphate decarboxylase activity
I1H34_05870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I1H34_05880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_05890	COG0517	IMP dehydrogenase activity
I1H34_05890	COG1994	Peptidase M50
I1H34_05895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1H34_05900	COG0134	indole-3-glycerol-phosphate synthase activity
I1H34_05915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I1H34_05920	COG1187	pseudouridine synthase activity
I1H34_05930	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I1H34_05935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_05940	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I1H34_05945	COG1691	(AIR) carboxylase
I1H34_05955	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I1H34_05960	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I1H34_05965	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_05970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1H34_05980	COG0612	Peptidase, M16
I1H34_05985	COG3210	domain, Protein
I1H34_06015	COG0686	Belongs to the AlaDH PNT family
I1H34_06025	COG2890	protein-(glutamine-N5) methyltransferase activity
I1H34_06050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1H34_06055	COG0515	serine threonine protein kinase
I1H34_06060	COG2815	serine threonine protein kinase
I1H34_06060	COG0515	serine threonine protein kinase
I1H34_06065	COG0515	serine threonine protein kinase
I1H34_06065	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_06070	COG0515	serine threonine protein kinase
I1H34_06075	COG0072	phenylalanine-tRNA ligase activity
I1H34_06075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1H34_06080	COG2203	Gaf domain
I1H34_06080	COG4251	negative regulation of phosphorylation
I1H34_06080	COG3706	GGDEF domain
I1H34_06080	COG5001	Diguanylate cyclase
I1H34_06085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I1H34_06160	COG4251	negative regulation of phosphorylation
I1H34_06165	COG0784	Response regulator, receiver
I1H34_06170	COG4251	negative regulation of phosphorylation
I1H34_06175	COG3335	DDE superfamily endonuclease
I1H34_06185	COG5002	protein histidine kinase activity
I1H34_06185	COG5001	Diguanylate cyclase
I1H34_06185	COG3447	MASE1 domain protein
I1H34_06205	COG2340	Cysteine-rich secretory protein family
I1H34_06210	COG2304	oxidoreductase activity
I1H34_06215	COG0640	Transcriptional regulator
I1H34_06220	COG2912	Transglutaminase-like superfamily
I1H34_06225	COG5002	protein histidine kinase activity
I1H34_06235	COG0557	exoribonuclease II activity
I1H34_06240	COG0704	Plays a role in the regulation of phosphate uptake
I1H34_06300	COG0137	argininosuccinate synthase activity
I1H34_06305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I1H34_06320	COG1077	Cell shape determining protein MreB Mrl
I1H34_06325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I1H34_06340	COG1492	cobalamin metabolic process
I1H34_06350	COG3956	TIGRFAM MazG family protein
I1H34_06385	COG0166	Belongs to the GPI family
I1H34_06400	COG2205	protein histidine kinase activity
I1H34_06405	COG3022	response to hydroperoxide
I1H34_06410	COG2226	methyltransferase
I1H34_06445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_06470	COG1132	(ABC) transporter
I1H34_06500	COG2814	Major facilitator Superfamily
I1H34_06520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1H34_06520	COG2022	thiamine diphosphate biosynthetic process
I1H34_06540	COG1595	DNA-templated transcription, initiation
I1H34_06555	COG2897	thiosulfate sulfurtransferase activity
I1H34_06560	COG4566	intracellular signal transduction
I1H34_06615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I1H34_06620	COG0563	adenylate kinase activity
I1H34_06625	COG0201	protein transport
I1H34_06630	COG0200	Binds to the 23S rRNA
I1H34_06635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I1H34_06640	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I1H34_06645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I1H34_06650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I1H34_06655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I1H34_06660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I1H34_06665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I1H34_06670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I1H34_06675	COG0255	Belongs to the universal ribosomal protein uL29 family
I1H34_06680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I1H34_06685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I1H34_06690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I1H34_06695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I1H34_06700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I1H34_06705	COG0089	rRNA binding
I1H34_06710	COG0088	Forms part of the polypeptide exit tunnel
I1H34_06715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I1H34_06755	COG2226	methyltransferase
I1H34_06765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I1H34_06780	COG1836	PFAM Integral membrane protein DUF92
I1H34_06790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I1H34_06795	COG0328	RNA-DNA hybrid ribonuclease activity
I1H34_06805	COG1078	dGTPase activity
I1H34_06810	COG0793	Belongs to the peptidase S41A family
I1H34_06815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1H34_06820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I1H34_06825	COG0242	peptide deformylase activity
I1H34_06830	COG0758	DNA mediated transformation
I1H34_06830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1H34_06835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1H34_06840	COG3239	Fatty acid desaturase
I1H34_06845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I1H34_06860	COG1595	DNA-templated transcription, initiation
I1H34_06870	COG1587	Uroporphyrinogen-III synthase
I1H34_06885	COG0601	transmembrane transport
I1H34_06895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I1H34_06905	COG0850	regulation of cytokinetic process
I1H34_06910	COG2894	cell division
I1H34_06915	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I1H34_06920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I1H34_06925	COG1543	Belongs to the glycosyl hydrolase 57 family
I1H34_06945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I1H34_06950	COG0438	transferase activity, transferring glycosyl groups
I1H34_06950	COG0297	glycogen (starch) synthase activity
I1H34_06960	COG1381	Involved in DNA repair and RecF pathway recombination
I1H34_06965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I1H34_06970	COG3735	TraB family
I1H34_06975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I1H34_07005	COG1131	(ABC) transporter
I1H34_07010	COG0109	protoheme IX farnesyltransferase activity
I1H34_07015	COG1612	heme a metabolic process
I1H34_07020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I1H34_07025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I1H34_07030	COG1845	cytochrome c oxidase, subunit III
I1H34_07035	COG0157	Belongs to the NadC ModD family
I1H34_07040	COG0583	DNA-binding transcription factor activity
I1H34_07045	COG0515	serine threonine protein kinase
I1H34_07065	COG2319	Wd-40 repeat
I1H34_07065	COG1672	PFAM Archaeal ATPase
I1H34_07080	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I1H34_07090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1H34_07115	COG4989	oxidoreductase activity
I1H34_07130	COG0259	pyridoxamine-phosphate oxidase activity
I1H34_07145	COG4249	Peptidase C14 caspase catalytic subunit p20
I1H34_07145	COG2319	Wd-40 repeat
I1H34_07170	COG0662	Cupin 2, conserved barrel domain protein
I1H34_07170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I1H34_07175	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1H34_07185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_07200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_07205	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1H34_07215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1H34_07225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I1H34_07235	COG0857	belongs to the CobB CobQ family
I1H34_07245	COG0535	radical SAM domain protein
I1H34_07250	COG1215	transferase activity, transferring glycosyl groups
I1H34_07255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I1H34_07265	COG1490	D-aminoacyl-tRNA deacylase activity
I1H34_07270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I1H34_07275	COG0539	negative regulation of cytoplasmic translation
I1H34_07285	COG3706	GGDEF domain
I1H34_07285	COG5001	Diguanylate cyclase
I1H34_07285	COG4251	negative regulation of phosphorylation
I1H34_07285	COG2203	Gaf domain
I1H34_07300	COG0714	Associated with various cellular activities
I1H34_07305	COG0714	Associated with various cellular activities
I1H34_07335	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I1H34_07340	COG2052	Domain of unknown function (DUF370)
I1H34_07345	COG0194	GDP metabolic process
I1H34_07355	COG0450	alkyl hydroperoxide reductase
I1H34_07365	COG0347	Belongs to the P(II) protein family
I1H34_07390	COG0557	exoribonuclease II activity
I1H34_07395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I1H34_07400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I1H34_07440	COG1324	tolerance protein
I1H34_07455	COG1562	ergosterol biosynthetic process
I1H34_07460	COG0493	'glutamate synthase
I1H34_07460	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I1H34_07465	COG2226	methyltransferase
I1H34_07500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I1H34_07510	COG0640	Transcriptional regulator
I1H34_07515	COG3118	belongs to the thioredoxin family
I1H34_07520	COG1902	pentaerythritol trinitrate reductase activity
I1H34_07535	COG1879	ABC-type sugar transport system periplasmic component
I1H34_07540	COG1657	PFAM Prenyltransferase squalene oxidase
I1H34_07560	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I1H34_07570	COG0793	Belongs to the peptidase S41A family
I1H34_07580	COG1429	ligase activity, forming nitrogen-metal bonds
I1H34_07585	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I1H34_07595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I1H34_07605	COG0612	Peptidase, M16
I1H34_07610	COG0612	Peptidase, M16
I1H34_07620	COG0489	protein tyrosine kinase activity
I1H34_07655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I1H34_07665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1H34_07680	COG3335	DDE superfamily endonuclease
I1H34_07705	COG0133	tryptophan synthase activity
I1H34_07715	COG0113	porphobilinogen synthase activity
I1H34_07785	COG3335	DDE superfamily endonuclease
I1H34_07840	COG1716	ATPase activity
I1H34_07840	COG5001	Diguanylate cyclase
I1H34_07845	COG0018	arginyl-trna synthetase
I1H34_07860	COG2226	methyltransferase
I1H34_07865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1H34_07870	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_07870	COG0515	serine threonine protein kinase
I1H34_07885	COG1316	TRANSCRIPTIONal
I1H34_07895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1H34_07900	COG1063	alcohol dehydrogenase
I1H34_07915	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I1H34_07920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I1H34_07925	COG0539	negative regulation of cytoplasmic translation
I1H34_07930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I1H34_07950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I1H34_07960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I1H34_07965	COG2046	Belongs to the sulfate adenylyltransferase family
I1H34_07985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I1H34_08000	COG0745	RESPONSE REGULATOR receiver
I1H34_08005	COG5002	protein histidine kinase activity
I1H34_08025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I1H34_08030	COG0481	GTPase activity
I1H34_08040	COG0501	Belongs to the peptidase M48B family
I1H34_08065	COG3659	wide pore channel activity
I1H34_08075	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I1H34_08100	COG2032	superoxide dismutase activity
I1H34_08160	COG3264	Mechanosensitive ion channel
I1H34_08160	COG1196	nuclear chromosome segregation
I1H34_08165	COG1716	ATPase activity
I1H34_08165	COG5001	Diguanylate cyclase
I1H34_08175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I1H34_08185	COG0756	dUTP diphosphatase activity
I1H34_08190	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1H34_08195	COG3657	addiction module killer protein
I1H34_08250	COG0515	serine threonine protein kinase
I1H34_08250	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_08270	COG3937	granule-associated protein
I1H34_08280	COG0783	Belongs to the Dps family
I1H34_08290	COG0673	inositol 2-dehydrogenase activity
I1H34_08300	COG1366	Belongs to the anti-sigma-factor antagonist family
I1H34_08310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1H34_08325	COG0505	Belongs to the CarA family
I1H34_08330	COG1716	ATPase activity
I1H34_08340	COG1175	transmembrane transport
I1H34_08345	COG1077	Cell shape determining protein MreB Mrl
I1H34_08360	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I1H34_08365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I1H34_08370	COG1408	metallophosphoesterase
I1H34_08380	COG0515	serine threonine protein kinase
I1H34_08380	COG3266	domain, Protein
I1H34_08420	COG3850	Histidine kinase
I1H34_08420	COG5002	protein histidine kinase activity
I1H34_08425	COG0745	RESPONSE REGULATOR receiver
I1H34_08430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1H34_08435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1H34_08440	COG1116	anion transmembrane transporter activity
I1H34_08440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I1H34_08445	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I1H34_08450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I1H34_08480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1H34_08485	COG2124	cytochrome p450
I1H34_08490	COG3300	MHYT domain
I1H34_08490	COG5001	Diguanylate cyclase
I1H34_08505	COG0514	ATP-dependent DNA helicase (RecQ)
I1H34_08510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_08520	COG5002	protein histidine kinase activity
I1H34_08530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1H34_08555	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I1H34_08560	COG0009	L-threonylcarbamoyladenylate synthase
I1H34_08565	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I1H34_08570	COG2198	Histidine kinase
I1H34_08570	COG0784	Response regulator, receiver
I1H34_08570	COG2205	protein histidine kinase activity
I1H34_08595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I1H34_08615	COG2319	Wd-40 repeat
I1H34_08615	COG3903	Transcriptional regulator
I1H34_08630	COG2319	Wd-40 repeat
I1H34_08630	COG4249	Peptidase C14 caspase catalytic subunit p20
I1H34_08645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1H34_08650	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_08650	COG0515	serine threonine protein kinase
I1H34_08665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_08670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I1H34_08680	COG2135	peptidase activity
I1H34_08685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1H34_08765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I1H34_08775	COG2197	response regulator
I1H34_08870	COG0586	Pfam SNARE associated Golgi protein
I1H34_08885	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I1H34_08930	COG0589	response to stress
I1H34_08935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I1H34_08945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_08955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I1H34_08960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I1H34_08965	COG0572	uridine kinase
I1H34_08975	COG0492	ferredoxin-NADP+ reductase activity
I1H34_08980	COG0142	geranyltranstransferase activity
I1H34_08985	COG0681	Belongs to the peptidase S26 family
I1H34_08990	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1H34_08995	COG1672	PFAM Archaeal ATPase
I1H34_09000	COG0824	Thioesterase
I1H34_09010	COG0811	peptide transport
I1H34_09015	COG0848	biopolymer transport protein
I1H34_09030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I1H34_09030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1H34_09040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I1H34_09055	COG0271	Belongs to the BolA IbaG family
I1H34_09060	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I1H34_09065	COG3063	Type IV pilus biogenesis stability protein PilW
I1H34_09075	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
I1H34_09080	COG0352	thiamine-phosphate diphosphorylase activity
I1H34_09105	COG3063	Type IV pilus biogenesis stability protein PilW
I1H34_09145	COG0793	Belongs to the peptidase S41A family
I1H34_09155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I1H34_09180	COG4251	negative regulation of phosphorylation
I1H34_09180	COG3706	GGDEF domain
I1H34_09180	COG2203	Gaf domain
I1H34_09180	COG5001	Diguanylate cyclase
I1H34_09190	COG5002	protein histidine kinase activity
I1H34_09190	COG5001	Diguanylate cyclase
I1H34_09195	COG2234	aminopeptidase activity
I1H34_09225	COG2319	Wd-40 repeat
I1H34_09225	COG1672	PFAM Archaeal ATPase
I1H34_09225	COG1672	PFAM Archaeal ATPase
I1H34_09225	COG2319	Wd-40 repeat
I1H34_09245	COG5002	protein histidine kinase activity
I1H34_09280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1H34_09295	COG1413	lyase activity
I1H34_09325	COG0039	L-malate dehydrogenase activity
I1H34_09330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I1H34_09350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I1H34_09365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1H34_09375	COG1555	photosystem II stabilization
I1H34_09380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1H34_09385	COG1994	Peptidase M50
I1H34_09385	COG0517	IMP dehydrogenase activity
I1H34_09420	COG1295	ribonuclease BN
I1H34_09420	COG1959	2 iron, 2 sulfur cluster binding
I1H34_09430	COG3237	CsbD-like
I1H34_09440	COG3437	response regulator, receiver
I1H34_09460	COG5487	UPF0391 membrane protein
I1H34_09465	COG3237	CsbD-like
I1H34_09470	COG0783	Belongs to the Dps family
I1H34_09500	COG1994	Peptidase M50
I1H34_09500	COG0517	IMP dehydrogenase activity
I1H34_09505	COG0589	response to stress
I1H34_09535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I1H34_09555	COG4251	negative regulation of phosphorylation
I1H34_09580	COG0784	Response regulator, receiver
I1H34_09585	COG4999	Histidine kinase
I1H34_09585	COG3850	Histidine kinase
I1H34_09585	COG2205	protein histidine kinase activity
I1H34_09585	COG3437	response regulator, receiver
I1H34_09590	COG0784	Response regulator, receiver
I1H34_09590	COG2205	protein histidine kinase activity
I1H34_09600	COG0668	transmembrane transport
I1H34_09625	COG1090	epimerase
I1H34_09635	COG2226	methyltransferase
I1H34_09645	COG0398	Pfam SNARE associated Golgi protein
I1H34_09650	COG0398	Pfam SNARE associated Golgi protein
I1H34_09665	COG0702	epimerase
I1H34_09705	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I1H34_09710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1H34_09710	COG4191	Histidine kinase
I1H34_09720	COG1361	Conserved repeat domain
I1H34_09725	COG0745	RESPONSE REGULATOR receiver
I1H34_09735	COG1620	l-lactate permease
I1H34_09750	COG0676	glucose-6-phosphate 1-epimerase activity
I1H34_09760	COG0829	nickel cation binding
I1H34_09765	COG0831	urea catabolic process
I1H34_09775	COG0431	NADPH-dependent FMN reductase
I1H34_09780	COG0832	Belongs to the urease beta subunit family
I1H34_09785	COG2205	protein histidine kinase activity
I1H34_09785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1H34_09795	COG0804	urea catabolic process
I1H34_09805	COG0393	Putative heavy-metal-binding
I1H34_09830	COG1132	(ABC) transporter
I1H34_09835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I1H34_09840	COG0033	Phosphoglucomutase
I1H34_09845	COG2808	Putative FMN-binding domain
I1H34_09855	COG0617	tRNA 3'-terminal CCA addition
I1H34_09875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I1H34_09885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_09900	COG3118	belongs to the thioredoxin family
I1H34_09915	COG0517	IMP dehydrogenase activity
I1H34_09915	COG0516	GMP reductase activity
I1H34_09930	COG1480	7TM receptor with intracellular HD hydrolase
I1H34_09935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1H34_09965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I1H34_09990	COG0123	including yeast histone deacetylase and acetoin utilization protein
I1H34_10030	COG2226	methyltransferase
I1H34_10040	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I1H34_10050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I1H34_10055	COG1606	tRNA processing
I1H34_10090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I1H34_10100	COG2259	Doxx family
I1H34_10105	COG0305	Participates in initiation and elongation during chromosome replication
I1H34_10105	COG1372	Participates in initiation and elongation during chromosome replication
I1H34_10105	COG0305	Participates in initiation and elongation during chromosome replication
I1H34_10105	COG1372	Participates in initiation and elongation during chromosome replication
I1H34_10110	COG0359	binds to the 23S rRNA
I1H34_10150	COG0515	serine threonine protein kinase
I1H34_10150	COG3266	domain, Protein
I1H34_10160	COG1187	pseudouridine synthase activity
I1H34_10165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I1H34_10170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I1H34_10180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I1H34_10185	COG1799	cell septum assembly
I1H34_10190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I1H34_10200	COG3842	ATPase activity
I1H34_10210	COG0596	Alpha beta hydrolase
I1H34_10215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I1H34_10220	COG0739	heme binding
I1H34_10240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_10245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1H34_10250	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_10255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_10260	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I1H34_10265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I1H34_10265	COG4451	ribulose bisphosphate carboxylase, small
I1H34_10270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I1H34_10275	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_10280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I1H34_10285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1H34_10300	COG1803	Methylglyoxal synthase
I1H34_10300	COG1597	lipid kinase activity
I1H34_10330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I1H34_10345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I1H34_10375	COG0583	DNA-binding transcription factor activity
I1H34_10390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I1H34_10400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I1H34_10405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I1H34_10435	COG0438	transferase activity, transferring glycosyl groups
I1H34_10440	COG3903	Transcriptional regulator
I1H34_10440	COG2319	Wd-40 repeat
I1H34_10445	COG0515	serine threonine protein kinase
I1H34_10445	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_10465	COG3300	MHYT domain
I1H34_10465	COG5001	Diguanylate cyclase
I1H34_10470	COG3920	Histidine kinase
I1H34_10485	COG0438	transferase activity, transferring glycosyl groups
I1H34_10510	COG5001	Diguanylate cyclase
I1H34_10515	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1H34_10520	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1H34_10530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I1H34_10535	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I1H34_10545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I1H34_10555	COG0483	inositol monophosphate 1-phosphatase activity
I1H34_10565	COG3273	potassium ion transport
I1H34_10565	COG0471	metal ion transport
I1H34_10570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1H34_10595	COG0789	Transcriptional regulator
I1H34_10600	COG0751	glycine-tRNA ligase activity
I1H34_10605	COG0612	Peptidase, M16
I1H34_10615	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1H34_10620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I1H34_10625	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1H34_10630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I1H34_10640	COG2124	cytochrome p450
I1H34_10650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1H34_10650	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I1H34_10655	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I1H34_10680	COG0408	coproporphyrinogen oxidase activity
I1H34_10685	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I1H34_10695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I1H34_10700	COG0501	Belongs to the peptidase M48B family
I1H34_10720	COG0739	heme binding
I1H34_10725	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I1H34_10725	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I1H34_10730	COG1496	oxidoreductase activity
I1H34_10760	COG1741	Belongs to the pirin family
I1H34_10770	COG2205	protein histidine kinase activity
I1H34_10770	COG0784	Response regulator, receiver
I1H34_10775	COG0589	response to stress
I1H34_10780	COG0126	phosphoglycerate kinase activity
I1H34_10795	COG0124	histidyl-tRNA synthetase
I1H34_10815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1H34_10820	COG0577	efflux transmembrane transporter activity
I1H34_10820	COG1136	(ABC) transporter
I1H34_10825	COG1136	(ABC) transporter
I1H34_10845	COG5001	Diguanylate cyclase
I1H34_10850	COG1994	Peptidase M50
I1H34_10850	COG0517	IMP dehydrogenase activity
I1H34_10855	COG0095	Lipoate-protein ligase
I1H34_10870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1H34_10875	COG0189	ligase activity
I1H34_10880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I1H34_10915	COG4279	zinc finger
I1H34_10935	COG0463	Glycosyl transferase, family 2
I1H34_10950	COG0514	ATP-dependent DNA helicase (RecQ)
I1H34_10970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_10985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I1H34_10995	COG5001	Diguanylate cyclase
I1H34_10995	COG5002	protein histidine kinase activity
I1H34_11000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1H34_11020	COG0628	permease
I1H34_11030	COG0003	Pfam Anion-transporting ATPase
I1H34_11035	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_11040	COG0825	malonyl-CoA metabolic process
I1H34_11045	COG0300	oxidoreductase activity
I1H34_11050	COG0302	gtp cyclohydrolase
I1H34_11065	COG0784	Response regulator, receiver
I1H34_11065	COG2205	protein histidine kinase activity
I1H34_11065	COG5002	protein histidine kinase activity
I1H34_11095	COG0418	dihydroorotase activity
I1H34_11105	COG2994	toxin metabolic process
I1H34_11170	COG2205	protein histidine kinase activity
I1H34_11170	COG0784	Response regulator, receiver
I1H34_11175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1H34_11195	COG2204	response regulator
I1H34_11235	COG0784	Response regulator, receiver
I1H34_11235	COG2205	protein histidine kinase activity
I1H34_11235	COG5002	protein histidine kinase activity
I1H34_11240	COG0121	glutamine amidotransferase
I1H34_11250	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I1H34_11255	COG0443	Heat shock 70 kDa protein
I1H34_11260	COG0484	heat shock protein binding
I1H34_11265	COG1704	LemA family
I1H34_11285	COG3046	protein related to deoxyribodipyrimidine photolyase
I1H34_11300	COG3266	domain, Protein
I1H34_11300	COG0515	serine threonine protein kinase
I1H34_11305	COG0515	serine threonine protein kinase
I1H34_11315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I1H34_11360	COG4178	(ABC) transporter
I1H34_11365	COG0483	inositol monophosphate 1-phosphatase activity
I1H34_11385	COG1160	GTP binding
I1H34_11410	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_11410	COG0515	serine threonine protein kinase
I1H34_11430	COG0326	Molecular chaperone. Has ATPase activity
I1H34_11435	COG4251	negative regulation of phosphorylation
I1H34_11445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1H34_11450	COG1185	polyribonucleotide nucleotidyltransferase activity
I1H34_11455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I1H34_11525	COG0776	regulation of translation
I1H34_11530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1H34_11540	COG0435	Glutathione S-transferase
I1H34_11545	COG1950	PFAM Membrane protein of
I1H34_11555	COG0697	spore germination
I1H34_11560	COG1846	Transcriptional regulator
I1H34_11565	COG4251	negative regulation of phosphorylation
I1H34_11570	COG0784	Response regulator, receiver
I1H34_11580	COG4251	negative regulation of phosphorylation
I1H34_11600	COG0659	secondary active sulfate transmembrane transporter activity
I1H34_11635	COG2273	Hydrolase Family 16
I1H34_11635	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I1H34_11640	COG5002	protein histidine kinase activity
I1H34_11650	COG0523	cobalamin synthesis protein
I1H34_11660	COG1032	radical SAM domain protein
I1H34_11670	COG3394	polysaccharide catabolic process
I1H34_11690	COG0107	imidazoleglycerol-phosphate synthase activity
I1H34_11700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1H34_11705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1H34_11715	COG0488	(ABC) transporter
I1H34_11720	COG1801	Protein of unknown function DUF72
I1H34_11725	COG0515	serine threonine protein kinase
I1H34_11740	COG2124	cytochrome p450
I1H34_11745	COG0138	bifunctional purine biosynthesis protein purh
I1H34_11750	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_11775	COG0438	transferase activity, transferring glycosyl groups
I1H34_11790	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I1H34_11795	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I1H34_11800	COG1494	fructose-1,6-bisphosphatase
I1H34_11810	COG0515	serine threonine protein kinase
I1H34_11810	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_11820	COG0473	3-isopropylmalate dehydrogenase activity
I1H34_11830	COG1131	(ABC) transporter
I1H34_11840	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I1H34_11845	COG2385	sporulation resulting in formation of a cellular spore
I1H34_11865	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I1H34_11865	COG0662	Cupin 2, conserved barrel domain protein
I1H34_11870	COG0316	Belongs to the HesB IscA family
I1H34_11895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1H34_11910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I1H34_11930	COG0438	transferase activity, transferring glycosyl groups
I1H34_11935	COG0438	transferase activity, transferring glycosyl groups
I1H34_11940	COG0489	protein tyrosine kinase activity
I1H34_11960	COG0463	Glycosyl transferase, family 2
I1H34_11960	COG1216	Glycosyl transferase, family 2
I1H34_11965	COG1132	(ABC) transporter
I1H34_11980	COG1216	Glycosyl transferase, family 2
I1H34_11990	COG1216	Glycosyl transferase, family 2
I1H34_11990	COG1442	glycosyl transferase family 8
I1H34_12005	COG0457	Tetratricopeptide repeat
I1H34_12085	COG0724	RNA recognition motif
I1H34_12125	COG5002	protein histidine kinase activity
I1H34_12125	COG0784	Response regulator, receiver
I1H34_12155	COG0716	FMN binding
I1H34_12160	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I1H34_12165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_12205	COG0745	RESPONSE REGULATOR receiver
I1H34_12250	COG1484	DNA-dependent DNA replication
I1H34_12270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I1H34_12280	COG0557	exoribonuclease II activity
I1H34_12380	COG3335	DDE superfamily endonuclease
I1H34_12510	COG1132	(ABC) transporter
I1H34_12520	COG1215	transferase activity, transferring glycosyl groups
I1H34_12525	COG1215	transferase activity, transferring glycosyl groups
I1H34_12540	COG0438	transferase activity, transferring glycosyl groups
I1H34_12550	COG0438	transferase activity, transferring glycosyl groups
I1H34_12585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I1H34_12650	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_12655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1H34_12685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I1H34_12695	COG2133	pyrroloquinoline quinone binding
I1H34_12705	COG1271	oxidase subunit
I1H34_12755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I1H34_12790	COG0405	Gamma-glutamyltransferase
I1H34_12800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I1H34_12810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_12820	COG0438	transferase activity, transferring glycosyl groups
I1H34_12840	COG0004	ammonium transporteR
I1H34_12870	COG3706	GGDEF domain
I1H34_12875	COG2988	succinylglutamate desuccinylase activity
I1H34_12890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I1H34_12890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I1H34_12910	COG0070	glutamate synthase
I1H34_12910	COG0067	glutamate synthase
I1H34_12910	COG0069	glutamate synthase activity
I1H34_12915	COG0515	serine threonine protein kinase
I1H34_12915	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_12920	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_12925	COG0306	phosphate transporter
I1H34_12940	COG2205	protein histidine kinase activity
I1H34_12940	COG0784	Response regulator, receiver
I1H34_12945	COG0784	Response regulator, receiver
I1H34_12945	COG2198	Histidine kinase
I1H34_12945	COG5002	protein histidine kinase activity
I1H34_12955	COG0493	'glutamate synthase
I1H34_12975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I1H34_13000	COG0189	ligase activity
I1H34_13005	COG0697	spore germination
I1H34_13025	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I1H34_13035	COG1254	Belongs to the acylphosphatase family
I1H34_13040	COG0745	RESPONSE REGULATOR receiver
I1H34_13060	COG3659	wide pore channel activity
I1H34_13080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1H34_13085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_13095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I1H34_13195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1H34_13220	COG0410	ABC transporter
I1H34_13255	COG4191	Histidine kinase
I1H34_13270	COG0784	Response regulator, receiver
I1H34_13270	COG2205	protein histidine kinase activity
I1H34_13275	COG2319	Wd-40 repeat
I1H34_13275	COG3903	Transcriptional regulator
I1H34_13280	COG0644	oxidoreductase
I1H34_13310	COG2197	response regulator
I1H34_13315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I1H34_13315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I1H34_13330	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I1H34_13335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1H34_13340	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I1H34_13355	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I1H34_13355	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I1H34_13360	COG0367	asparagine synthase
I1H34_13370	COG2066	Belongs to the glutaminase family
I1H34_13375	COG0517	IMP dehydrogenase activity
I1H34_13375	COG1125	glycine betaine transport
I1H34_13395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I1H34_13410	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_13515	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_13515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1H34_13515	COG0300	oxidoreductase activity
I1H34_13515	COG3321	synthase
I1H34_13515	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_13515	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_13515	COG3321	synthase
I1H34_13515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1H34_13515	COG0300	oxidoreductase activity
I1H34_13515	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_13525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1H34_13530	COG2894	cell division
I1H34_13550	COG0438	transferase activity, transferring glycosyl groups
I1H34_13555	COG0438	transferase activity, transferring glycosyl groups
I1H34_13615	COG5433	transposase activity
I1H34_13625	COG1484	DNA-dependent DNA replication
I1H34_13700	COG1484	DNA-dependent DNA replication
I1H34_13710	COG5433	transposase activity
I1H34_13750	COG0516	GMP reductase activity
I1H34_13750	COG0517	IMP dehydrogenase activity
I1H34_13760	COG0616	signal peptide processing
I1H34_13765	COG0697	spore germination
I1H34_13770	COG2233	PERMEase
I1H34_13785	COG5002	protein histidine kinase activity
I1H34_13795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I1H34_13815	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I1H34_13815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I1H34_13830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I1H34_13860	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I1H34_13865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I1H34_13875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I1H34_13890	COG3659	wide pore channel activity
I1H34_13900	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_13905	COG0802	atpase or kinase
I1H34_13915	COG0702	epimerase
I1H34_13965	COG1217	gtp-binding protein TYPA
I1H34_13970	COG5002	protein histidine kinase activity
I1H34_13970	COG0784	Response regulator, receiver
I1H34_13975	COG3706	GGDEF domain
I1H34_13975	COG4251	negative regulation of phosphorylation
I1H34_13975	COG5001	Diguanylate cyclase
I1H34_13975	COG2203	Gaf domain
I1H34_13980	COG0432	Pfam Uncharacterised protein family UPF0047
I1H34_13985	COG1840	ABC-type Fe3 transport system, periplasmic component
I1H34_13990	COG1196	nuclear chromosome segregation
I1H34_13990	COG3264	Mechanosensitive ion channel
I1H34_14005	COG0598	Magnesium transport protein CorA
I1H34_14020	COG0705	Rhomboid family
I1H34_14020	COG0457	Tetratricopeptide repeat
I1H34_14030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1H34_14070	COG3536	Protein conserved in bacteria
I1H34_14075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I1H34_14090	COG0315	cyclic pyranopterin monophosphate synthase activity
I1H34_14115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I1H34_14130	COG1595	DNA-templated transcription, initiation
I1H34_14150	COG0513	Belongs to the DEAD box helicase family
I1H34_14155	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_14160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_14165	COG1260	myo-inositol-1-phosphate synthase
I1H34_14180	COG0837	glucose binding
I1H34_14185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I1H34_14190	COG0366	Alpha amylase catalytic
I1H34_14195	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I1H34_14195	COG3291	Pkd domain containing protein
I1H34_14210	COG0672	)-iron permease
I1H34_14230	COG0515	serine threonine protein kinase
I1H34_14230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1H34_14255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_14270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I1H34_14280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I1H34_14320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I1H34_14340	COG0072	phenylalanine-tRNA ligase activity
I1H34_14440	COG4251	negative regulation of phosphorylation
I1H34_14445	COG0784	Response regulator, receiver
I1H34_14450	COG2204	response regulator
I1H34_14455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I1H34_14460	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I1H34_14495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1H34_14535	COG4191	Histidine kinase
I1H34_14540	COG2197	response regulator
I1H34_14560	COG1222	aaa ATPase
I1H34_14580	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I1H34_14600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I1H34_14600	COG3608	succinylglutamate desuccinylase aspartoacylase
I1H34_14615	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I1H34_14650	COG1943	Transposase
I1H34_14665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I1H34_14670	COG0573	inorganic phosphate transmembrane transporter activity
I1H34_14675	COG0581	inorganic phosphate transmembrane transporter activity
I1H34_14680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I1H34_14690	COG3903	Transcriptional regulator
I1H34_14690	COG2319	Wd-40 repeat
I1H34_14710	COG0175	sulfate reduction
I1H34_14745	COG5285	phytanoyl-CoA dioxygenase
I1H34_14780	COG0110	maltose O-acetyltransferase activity
I1H34_14800	COG0438	transferase activity, transferring glycosyl groups
I1H34_14815	COG0297	glycogen (starch) synthase activity
I1H34_14815	COG0438	transferase activity, transferring glycosyl groups
I1H34_14825	COG1045	serine acetyltransferase
I1H34_14840	COG1216	Glycosyl transferase, family 2
I1H34_14845	COG0438	transferase activity, transferring glycosyl groups
I1H34_14860	COG2089	acid synthase
I1H34_14865	COG1083	cytidylyl-transferase
I1H34_14910	COG0489	protein tyrosine kinase activity
I1H34_14930	COG0745	RESPONSE REGULATOR receiver
I1H34_14935	COG5002	protein histidine kinase activity
I1H34_14985	COG0542	response to heat
I1H34_14995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I1H34_15005	COG0529	Catalyzes the synthesis of activated sulfate
I1H34_15015	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I1H34_15020	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1H34_15035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1H34_15040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1H34_15050	COG0484	heat shock protein binding
I1H34_15055	COG1459	type II secretion system
I1H34_15085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I1H34_15090	COG0443	Heat shock 70 kDa protein
I1H34_15095	COG0484	heat shock protein binding
I1H34_15105	COG1162	GTPase activity
I1H34_15125	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I1H34_15130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I1H34_15160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I1H34_15180	COG0515	serine threonine protein kinase
I1H34_15210	COG0508	dehydrogenase complex catalyzes the overall conversion of
I1H34_15210	COG0022	dehydrogenase e1 component
I1H34_15215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1H34_15220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I1H34_15340	COG1487	ribonuclease activity
I1H34_15360	COG2852	Protein conserved in bacteria
I1H34_15380	COG0390	transport system, permease component
I1H34_15390	COG1994	Peptidase M50
I1H34_15395	COG0484	heat shock protein binding
I1H34_15410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1H34_15415	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_15415	COG0515	serine threonine protein kinase
I1H34_15420	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I1H34_15440	COG0517	IMP dehydrogenase activity
I1H34_15440	COG1125	glycine betaine transport
I1H34_15445	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_15450	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I1H34_15460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1H34_15465	COG0416	fatty acid biosynthetic process
I1H34_15480	COG4399	Belongs to the UPF0754 family
I1H34_15485	COG1131	(ABC) transporter
I1H34_15490	COG0631	protein serine/threonine phosphatase activity
I1H34_15495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1H34_15500	COG3937	granule-associated protein
I1H34_15505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I1H34_15520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I1H34_15520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I1H34_15530	COG0577	efflux transmembrane transporter activity
I1H34_15545	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I1H34_15555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I1H34_15555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I1H34_15570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I1H34_15580	COG1429	ligase activity, forming nitrogen-metal bonds
I1H34_15590	COG1022	Amp-dependent synthetase and ligase
I1H34_15605	COG0482	sulfurtransferase activity
I1H34_15610	COG0724	RNA recognition motif
I1H34_15615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I1H34_15620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I1H34_15635	COG0793	Belongs to the peptidase S41A family
I1H34_15645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I1H34_15655	COG0438	transferase activity, transferring glycosyl groups
I1H34_15660	COG0438	transferase activity, transferring glycosyl groups
I1H34_15670	COG0297	glycogen (starch) synthase activity
I1H34_15685	COG1234	tRNA 3'-trailer cleavage
I1H34_15715	COG5002	protein histidine kinase activity
I1H34_15750	COG0556	nucleotide-excision repair
I1H34_15755	COG2205	protein histidine kinase activity
I1H34_15765	COG2048	Heterodisulfide reductase, subunit B
I1H34_15780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1H34_15785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1H34_15790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1H34_15800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I1H34_15810	COG0193	aminoacyl-tRNA hydrolase activity
I1H34_15815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I1H34_15835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I1H34_15845	COG0233	cytoplasmic translational termination
I1H34_15850	COG0528	UMP kinase activity
I1H34_15870	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I1H34_15915	COG0668	transmembrane transport
I1H34_15940	COG1136	(ABC) transporter
I1H34_15950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I1H34_15960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_15970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I1H34_15990	COG2205	protein histidine kinase activity
I1H34_16010	COG2217	Heavy metal translocating P-type atpase
I1H34_16030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_16035	COG0469	pyruvate kinase activity
I1H34_16040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I1H34_16045	COG0625	glutathione transferase activity
I1H34_16060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1H34_16065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I1H34_16075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I1H34_16120	COG0195	Participates in both transcription termination and antitermination
I1H34_16125	COG0779	Required for maturation of 30S ribosomal subunits
I1H34_16140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I1H34_16145	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I1H34_16160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1H34_16165	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I1H34_16180	COG0643	Histidine kinase
I1H34_16180	COG2198	Histidine kinase
I1H34_16180	COG0784	Response regulator, receiver
I1H34_16185	COG0840	transmembrane signaling receptor activity
I1H34_16200	COG0784	Response regulator, receiver
I1H34_16210	COG0066	3-isopropylmalate dehydratase activity
I1H34_16225	COG4636	protein conserved in cyanobacteria
I1H34_16230	COG0473	3-isopropylmalate dehydrogenase activity
I1H34_16240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I1H34_16245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I1H34_16250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I1H34_16255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1H34_16260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I1H34_16270	COG0356	it plays a direct role in the translocation of protons across the membrane
I1H34_16320	COG0175	sulfate reduction
I1H34_16325	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I1H34_16340	COG0830	nickel cation binding
I1H34_16345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1H34_16350	COG3659	wide pore channel activity
I1H34_16360	COG0559	Belongs to the binding-protein-dependent transport system permease family
I1H34_16380	COG0625	glutathione transferase activity
I1H34_16385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I1H34_16390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I1H34_16415	COG5398	heme oxygenase
I1H34_16420	COG1970	mechanosensitive ion channel activity
I1H34_16425	COG0275	rRNA processing
I1H34_16435	COG0768	penicillin binding
I1H34_16440	COG3011	Protein conserved in bacteria
I1H34_16450	COG0612	Peptidase, M16
I1H34_16470	COG1233	COG1233 Phytoene dehydrogenase and related
I1H34_16485	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I1H34_16485	COG1672	PFAM Archaeal ATPase
I1H34_16490	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I1H34_16500	COG0745	RESPONSE REGULATOR receiver
I1H34_16510	COG0484	heat shock protein binding
I1H34_16515	COG2124	cytochrome p450
I1H34_16525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1H34_16535	COG1309	transcriptional regulator
I1H34_16540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_16545	COG1122	ATPase activity
I1H34_16555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I1H34_16560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I1H34_16580	COG0438	transferase activity, transferring glycosyl groups
I1H34_16600	COG0431	NADPH-dependent FMN reductase
I1H34_16620	COG0745	RESPONSE REGULATOR receiver
I1H34_16630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I1H34_16630	COG0646	methionine synthase
I1H34_16640	COG1615	UPF0182 protein
I1H34_16655	COG1515	deoxyribonuclease V activity
I1H34_16660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1H34_16680	COG1361	Conserved repeat domain
I1H34_16715	COG0300	oxidoreductase activity
I1H34_16725	COG0156	8-amino-7-oxononanoate synthase activity
I1H34_16730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I1H34_16730	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_16730	COG4221	oxidoreductase activity
I1H34_16730	COG3321	synthase
I1H34_16755	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_16765	COG0534	Mate efflux family protein
I1H34_16780	COG2258	MOSC domain
I1H34_16825	COG4149	molybdate abc transporter
I1H34_16830	COG0725	ABC transporter, periplasmic molybdate-binding protein
I1H34_16845	COG2363	Small membrane protein
I1H34_16860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1H34_16865	COG0724	RNA recognition motif
I1H34_16875	COG2205	protein histidine kinase activity
I1H34_16875	COG5002	protein histidine kinase activity
I1H34_16875	COG0784	Response regulator, receiver
I1H34_16920	COG0564	pseudouridine synthase activity
I1H34_16945	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I1H34_17005	COG0814	amino acid
I1H34_17010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I1H34_17020	COG0587	DNA-directed DNA polymerase activity
I1H34_17040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I1H34_17045	COG2226	methyltransferase
I1H34_17055	COG1446	asparaginase
I1H34_17070	COG2095	MarC family integral membrane protein
I1H34_17080	COG0653	protein targeting
I1H34_17105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I1H34_17115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I1H34_17125	COG1054	Belongs to the UPF0176 family
I1H34_17135	COG3239	Fatty acid desaturase
I1H34_17150	COG0277	FAD linked oxidase domain protein
I1H34_17155	COG1799	cell septum assembly
I1H34_17160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I1H34_17180	COG1968	undecaprenyl-diphosphatase activity
I1H34_17185	COG1233	COG1233 Phytoene dehydrogenase and related
I1H34_17190	COG0024	Methionine aminopeptidase
I1H34_17210	COG0424	maF-like protein
I1H34_17260	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1H34_17265	COG3657	addiction module killer protein
I1H34_17280	COG0495	leucyl-tRNA aminoacylation
I1H34_17320	COG1216	Glycosyl transferase, family 2
I1H34_17330	COG0438	transferase activity, transferring glycosyl groups
I1H34_17350	COG0515	serine threonine protein kinase
I1H34_17350	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_17355	COG0640	Transcriptional regulator
I1H34_17365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I1H34_17375	COG1126	abc transporter atp-binding protein
I1H34_17380	COG0765	amino acid transport
I1H34_17385	COG4597	amino acid ABC transporter
I1H34_17390	COG0517	IMP dehydrogenase activity
I1H34_17390	COG0617	tRNA 3'-terminal CCA addition
I1H34_17390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I1H34_17400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I1H34_17410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1H34_17430	COG1045	serine acetyltransferase
I1H34_17445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I1H34_17460	COG4251	negative regulation of phosphorylation
I1H34_17465	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I1H34_17470	COG0457	Tetratricopeptide repeat
I1H34_17470	COG0463	Glycosyl transferase, family 2
I1H34_17495	COG1136	(ABC) transporter
I1H34_17530	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1H34_17530	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
I1H34_17535	COG4372	Transposase
I1H34_17550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I1H34_17565	COG1191	sigma factor activity
I1H34_17570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I1H34_17575	COG0657	acetylesterase activity
I1H34_17605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I1H34_17610	COG4585	Histidine kinase
I1H34_17615	COG2197	response regulator
I1H34_17640	COG0681	Belongs to the peptidase S26 family
I1H34_17655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I1H34_17660	COG5001	Diguanylate cyclase
I1H34_17660	COG4251	negative regulation of phosphorylation
I1H34_17660	COG2203	Gaf domain
I1H34_17660	COG3706	GGDEF domain
I1H34_17670	COG3457	Alanine racemase
I1H34_17680	COG0724	RNA recognition motif
I1H34_17685	COG0724	RNA recognition motif
I1H34_17705	COG3706	GGDEF domain
I1H34_17715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I1H34_17740	COG1192	Involved in chromosome partitioning
I1H34_17745	COG0583	DNA-binding transcription factor activity
I1H34_17760	COG0501	Belongs to the peptidase M48B family
I1H34_17770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I1H34_17780	COG2203	Gaf domain
I1H34_17780	COG4251	negative regulation of phosphorylation
I1H34_17780	COG3706	GGDEF domain
I1H34_17780	COG5001	Diguanylate cyclase
I1H34_17810	COG3541	Predicted nucleotidyltransferase
I1H34_17825	COG0840	transmembrane signaling receptor activity
I1H34_17845	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I1H34_17855	COG1575	Belongs to the MenA family. Type 1 subfamily
I1H34_17860	COG0484	heat shock protein binding
I1H34_17865	COG0702	epimerase
I1H34_17870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I1H34_17875	COG0322	excinuclease ABC activity
I1H34_17880	COG0297	glycogen (starch) synthase activity
I1H34_17890	COG1309	transcriptional regulator
I1H34_17900	COG1649	PFAM Uncharacterised BCR, COG1649
I1H34_17915	COG0735	belongs to the Fur family
I1H34_17950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I1H34_17960	COG1420	regulation of RNA biosynthetic process
I1H34_18005	COG0776	regulation of translation
I1H34_18010	COG0575	Belongs to the CDS family
I1H34_18020	COG0745	RESPONSE REGULATOR receiver
I1H34_18030	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I1H34_18035	COG1051	belongs to the nudix hydrolase family
I1H34_18040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1H34_18055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I1H34_18095	COG1331	Highly conserved protein containing a thioredoxin domain
I1H34_18120	COG1671	Belongs to the UPF0178 family
I1H34_18125	COG4106	trans-aconitate 2-methyltransferase activity
I1H34_18140	COG0625	glutathione transferase activity
I1H34_18155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1H34_18155	COG2205	protein histidine kinase activity
I1H34_18160	COG2205	protein histidine kinase activity
I1H34_18160	COG2198	Histidine kinase
I1H34_18160	COG0784	Response regulator, receiver
I1H34_18170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I1H34_18210	COG0523	cobalamin synthesis protein
I1H34_18245	COG5635	Nacht domain
I1H34_18245	COG2319	Wd-40 repeat
I1H34_18260	COG1252	NADH dehydrogenase
I1H34_18270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1H34_18305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I1H34_18310	COG0719	Fe-S assembly protein
I1H34_18315	COG0396	ATPase activity
I1H34_18320	COG0719	Fe-S assembly protein
I1H34_18330	COG0456	acetyltransferase
I1H34_18345	COG1309	transcriptional regulator
I1H34_18410	COG4221	oxidoreductase activity
I1H34_18415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I1H34_18420	COG1376	ErfK ybiS ycfS ynhG family protein
I1H34_18425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I1H34_18430	COG0254	rRNA binding
I1H34_18435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I1H34_18440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I1H34_18445	COG0101	tRNA pseudouridine synthase activity
I1H34_18450	COG0203	ribosomal protein L17
I1H34_18455	COG0202	RNA polymerase activity
I1H34_18460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I1H34_18465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I1H34_18470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I1H34_18475	COG0646	methionine synthase
I1H34_18475	COG1410	methionine synthase
I1H34_18505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1H34_18520	COG2827	Endonuclease containing a URI domain
I1H34_18570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I1H34_18575	COG2264	protein methyltransferase activity
I1H34_18605	COG1361	Conserved repeat domain
I1H34_18605	COG2911	Protein conserved in bacteria
I1H34_18605	COG3266	domain, Protein
I1H34_18610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I1H34_18615	COG4956	integral membrane protein (PIN domain superfamily)
I1H34_18625	COG0159	tryptophan synthase activity
I1H34_18640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I1H34_18650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I1H34_18675	COG0606	chelatase, subunit chli
I1H34_18680	COG3063	Type IV pilus biogenesis stability protein PilW
I1H34_18685	COG4172	Belongs to the ABC transporter superfamily
I1H34_18690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_18700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1H34_18705	COG2045	Belongs to the ComB family
I1H34_18725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_18730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I1H34_18740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I1H34_18745	COG0339	signal peptide processing
I1H34_18750	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_18750	COG0515	serine threonine protein kinase
I1H34_18755	COG0840	transmembrane signaling receptor activity
I1H34_18755	COG2203	Gaf domain
I1H34_18760	COG2205	protein histidine kinase activity
I1H34_18760	COG0784	Response regulator, receiver
I1H34_18770	COG0303	'Molybdopterin
I1H34_18780	COG0426	domain, Protein
I1H34_18780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1H34_18790	COG0426	domain, Protein
I1H34_18790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I1H34_18805	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I1H34_18825	COG0114	fumarate hydratase activity
I1H34_18850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I1H34_18855	COG1196	nuclear chromosome segregation
I1H34_18855	COG3264	Mechanosensitive ion channel
I1H34_18865	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1H34_18870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I1H34_18890	COG1473	amidohydrolase
I1H34_18920	COG2308	Evidence 4 Homologs of previously reported genes of
I1H34_18925	COG5002	protein histidine kinase activity
I1H34_18925	COG5001	Diguanylate cyclase
I1H34_18930	COG0709	Synthesizes selenophosphate from selenide and ATP
I1H34_18970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1H34_18975	COG2319	Wd-40 repeat
I1H34_18975	COG3903	Transcriptional regulator
I1H34_18980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1H34_18985	COG0546	phosphoglycolate phosphatase activity
I1H34_19000	COG0512	Glutamine amidotransferase of anthranilate synthase
I1H34_19005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I1H34_19010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I1H34_19020	COG0047	phosphoribosylformylglycinamidine synthase activity
I1H34_19025	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1H34_19030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I1H34_19040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I1H34_19040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I1H34_19055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I1H34_19070	COG1278	Cold shock
I1H34_19075	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1H34_19080	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
I1H34_19090	COG0489	protein tyrosine kinase activity
I1H34_19095	COG0772	Belongs to the SEDS family
I1H34_19110	COG0539	negative regulation of cytoplasmic translation
I1H34_19115	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I1H34_19130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1H34_19150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I1H34_19170	COG0071	Belongs to the small heat shock protein (HSP20) family
I1H34_19190	COG2161	toxin-antitoxin pair type II binding
I1H34_19195	COG4115	mRNA cleavage
I1H34_19210	COG1233	COG1233 Phytoene dehydrogenase and related
I1H34_19240	COG0745	RESPONSE REGULATOR receiver
I1H34_19270	COG0762	integral membrane protein
I1H34_19275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I1H34_19290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I1H34_19300	COG0174	glutamine synthetase
I1H34_19310	COG0784	Response regulator, receiver
I1H34_19310	COG5002	protein histidine kinase activity
I1H34_19335	COG2239	Acts as a magnesium transporter
I1H34_19345	COG0191	fructose-bisphosphate aldolase activity
I1H34_19350	COG0739	heme binding
I1H34_19355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I1H34_19360	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I1H34_19370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I1H34_19400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I1H34_19405	COG1063	alcohol dehydrogenase
I1H34_19415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I1H34_19420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I1H34_19430	COG0509	glycine decarboxylation via glycine cleavage system
I1H34_19435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I1H34_19460	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
I1H34_19465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1H34_19500	COG1733	regulation of RNA biosynthetic process
I1H34_19515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1H34_19520	COG1121	(ABC) transporter
I1H34_19525	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1H34_19535	COG0784	Response regulator, receiver
I1H34_19535	COG2198	Histidine kinase
I1H34_19535	COG2205	protein histidine kinase activity
I1H34_19570	COG2226	methyltransferase
I1H34_19590	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I1H34_19610	COG0515	serine threonine protein kinase
I1H34_19610	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_19615	COG1216	Glycosyl transferase, family 2
I1H34_19625	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_19625	COG0515	serine threonine protein kinase
I1H34_19630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1H34_19645	COG1136	(ABC) transporter
I1H34_19690	COG0604	alcohol dehydrogenase
I1H34_19695	COG1024	Enoyl-CoA hydratase
I1H34_19700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I1H34_19705	COG4221	oxidoreductase activity
I1H34_19725	COG5001	Diguanylate cyclase
I1H34_19725	COG4251	negative regulation of phosphorylation
I1H34_19725	COG3706	GGDEF domain
I1H34_19725	COG2203	Gaf domain
I1H34_19730	COG1049	propionate catabolic process, 2-methylcitrate cycle
I1H34_19750	COG0135	phosphoribosylanthranilate isomerase activity
I1H34_19755	COG0167	dihydroorotate dehydrogenase activity
I1H34_19770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I1H34_19780	COG0574	Belongs to the PEP-utilizing enzyme family
I1H34_19780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1H34_19785	COG0589	response to stress
I1H34_19800	COG1305	Transglutaminase-like
I1H34_19820	COG3854	ATPases associated with a variety of cellular activities
I1H34_19835	COG0492	ferredoxin-NADP+ reductase activity
I1H34_19840	COG1166	arginine decarboxylase activity
I1H34_19850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_19855	COG2340	Cysteine-rich secretory protein family
I1H34_19860	COG0070	glutamate synthase
I1H34_19860	COG0069	glutamate synthase activity
I1H34_19860	COG0067	glutamate synthase
I1H34_19865	COG0784	Response regulator, receiver
I1H34_19865	COG2198	Histidine kinase
I1H34_19865	COG5002	protein histidine kinase activity
I1H34_19870	COG3437	response regulator, receiver
I1H34_19880	COG0121	glutamine amidotransferase
I1H34_19900	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I1H34_19905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I1H34_19935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1H34_19940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I1H34_19950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I1H34_19970	COG1032	radical SAM domain protein
I1H34_19990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I1H34_19995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I1H34_20005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I1H34_20010	COG0513	Belongs to the DEAD box helicase family
I1H34_20015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I1H34_20020	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I1H34_20025	COG1530	ribonuclease E activity
I1H34_20030	COG0412	Dienelactone hydrolase
I1H34_20035	COG1725	Transcriptional regulator
I1H34_20040	COG2304	oxidoreductase activity
I1H34_20055	COG0612	Peptidase, M16
I1H34_20075	COG0571	ribonuclease III activity
I1H34_20080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I1H34_20085	COG0484	heat shock protein binding
I1H34_20090	COG0037	tRNA processing
I1H34_20095	COG0745	RESPONSE REGULATOR receiver
I1H34_20120	COG0784	Response regulator, receiver
I1H34_20125	COG4251	negative regulation of phosphorylation
I1H34_20130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1H34_20145	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I1H34_20155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I1H34_20165	COG0180	Tryptophanyl-tRNA synthetase
I1H34_20170	COG2205	protein histidine kinase activity
I1H34_20180	COG0285	dihydrofolate synthase activity
I1H34_20205	COG1132	(ABC) transporter
I1H34_20210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I1H34_20215	COG2010	Cytochrome c
I1H34_20260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I1H34_20265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I1H34_20280	COG3335	DDE superfamily endonuclease
I1H34_20300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1H34_20310	COG3335	DDE superfamily endonuclease
I1H34_20350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I1H34_20355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I1H34_20450	COG4451	ribulose bisphosphate carboxylase, small
I1H34_20450	COG0464	growth
I1H34_20475	COG4451	ribulose bisphosphate carboxylase, small
I1H34_20485	COG1850	ribulose-bisphosphate carboxylase activity
I1H34_20490	COG0454	-acetyltransferase
I1H34_20505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I1H34_20525	COG0051	transcription antitermination factor activity, RNA binding
I1H34_20530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I1H34_20535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1H34_20540	COG0049	tRNA binding
I1H34_20545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I1H34_20550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I1H34_20555	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I1H34_20560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I1H34_20580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I1H34_20585	COG0745	RESPONSE REGULATOR receiver
I1H34_20595	COG1333	cytochrome c biogenesis protein
I1H34_20605	COG0772	Belongs to the SEDS family
I1H34_20625	COG3659	wide pore channel activity
I1H34_20640	COG0783	Belongs to the Dps family
I1H34_20645	COG1136	(ABC) transporter
I1H34_20685	COG0659	secondary active sulfate transmembrane transporter activity
I1H34_20690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_20695	COG2217	Heavy metal translocating P-type atpase
I1H34_20715	COG2321	neutral zinc metallopeptidase
I1H34_20755	COG1174	glycine betaine transport
I1H34_20770	COG0217	transcriptional regulatory protein
I1H34_20780	COG2884	Cell division ATP-binding protein ftsE
I1H34_20785	COG2177	Part of the ABC transporter FtsEX involved in
I1H34_20840	COG1666	GTP binding
I1H34_20845	COG1012	belongs to the aldehyde dehydrogenase family
I1H34_20860	COG0516	GMP reductase activity
I1H34_20865	COG3118	belongs to the thioredoxin family
I1H34_20875	COG5002	protein histidine kinase activity
I1H34_20875	COG2205	protein histidine kinase activity
I1H34_20875	COG0784	Response regulator, receiver
I1H34_20895	COG0693	protein deglycase activity
I1H34_20925	COG0436	Aminotransferase
I1H34_20940	COG0540	Belongs to the ATCase OTCase family
I1H34_20950	COG1122	ATPase activity
I1H34_20965	COG3594	Acyltransferase
I1H34_20975	COG2226	methyltransferase
I1H34_20985	COG0438	transferase activity, transferring glycosyl groups
I1H34_20995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1H34_21015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I1H34_21025	COG2244	polysaccharide biosynthetic process
I1H34_21035	COG0438	transferase activity, transferring glycosyl groups
I1H34_21055	COG0367	asparagine synthase
I1H34_21060	COG2850	peptidyl-arginine hydroxylation
I1H34_21065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I1H34_21090	COG1473	amidohydrolase
I1H34_21110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I1H34_21115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1H34_21135	COG0360	Binds together with S18 to 16S ribosomal RNA
I1H34_21140	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I1H34_21160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I1H34_21165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1H34_21175	COG1058	Belongs to the CinA family
I1H34_21175	COG1546	Belongs to the CinA family
I1H34_21185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I1H34_21190	COG0488	(ABC) transporter
I1H34_21200	COG0454	-acetyltransferase
I1H34_21200	COG0456	acetyltransferase
I1H34_21205	COG0542	response to heat
I1H34_21220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I1H34_21230	COG0037	tRNA processing
I1H34_21250	COG0352	thiamine-phosphate diphosphorylase activity
I1H34_21260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1H34_21265	COG0745	RESPONSE REGULATOR receiver
I1H34_21275	COG1858	cytochrome C peroxidase
I1H34_21280	COG2205	protein histidine kinase activity
I1H34_21280	COG0784	Response regulator, receiver
I1H34_21295	COG0434	BtpA family
I1H34_21300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_21305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I1H34_21310	COG0494	nUDIX hydrolase
I1H34_21315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1H34_21330	COG3596	GTP binding
I1H34_21370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1H34_21380	COG0326	Molecular chaperone. Has ATPase activity
I1H34_21385	COG3220	belongs to the UPF0276 family
I1H34_21415	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I1H34_21445	COG1233	COG1233 Phytoene dehydrogenase and related
I1H34_21475	COG2226	methyltransferase
I1H34_21480	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I1H34_21495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I1H34_21510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I1H34_21525	COG0017	Asparaginyl-tRNA synthetase
I1H34_21535	COG0297	glycogen (starch) synthase activity
I1H34_21540	COG0724	RNA recognition motif
I1H34_21565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I1H34_21570	COG3977	Valine--pyruvate aminotransferase
I1H34_21600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I1H34_21640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I1H34_21645	COG1007	ATP synthesis coupled electron transport
I1H34_21655	COG0644	oxidoreductase
I1H34_21665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I1H34_21670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I1H34_21680	COG0742	ribosomal rna small subunit methyltransferase
I1H34_21710	COG0443	Heat shock 70 kDa protein
I1H34_21725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I1H34_21730	COG0460	homoserine dehydrogenase
I1H34_21740	COG0456	acetyltransferase
I1H34_21755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I1H34_21760	COG0616	signal peptide processing
I1H34_21795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I1H34_21815	COG0793	Belongs to the peptidase S41A family
I1H34_21825	COG0747	negative chemotaxis
I1H34_21830	COG1858	cytochrome C peroxidase
I1H34_21835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I1H34_21845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I1H34_21895	COG1640	4-alpha-glucanotransferase
I1H34_21900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I1H34_21920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_21925	COG0735	belongs to the Fur family
I1H34_21935	COG0572	uridine kinase
I1H34_21940	COG0058	SHG alpha-glucan phosphorylase activity
I1H34_21945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1H34_21955	COG2267	carboxylic ester hydrolase activity
I1H34_21960	COG0440	acetolactate synthase activity
I1H34_21980	COG0439	Biotin carboxylase
I1H34_21990	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I1H34_21995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I1H34_22000	COG0542	response to heat
I1H34_22010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1H34_22020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_22030	COG0475	glutathione-regulated potassium exporter activity
I1H34_22040	COG0039	L-malate dehydrogenase activity
I1H34_22070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1H34_22070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I1H34_22095	COG2062	phosphohistidine phosphatase, SixA
I1H34_22100	COG0372	Belongs to the citrate synthase family
I1H34_22105	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I1H34_22110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_22130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I1H34_22135	COG4221	oxidoreductase activity
I1H34_22150	COG0561	phosphatase activity
I1H34_22155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1H34_22160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I1H34_22185	COG0537	adenosine 5'-monophosphoramidase activity
I1H34_22195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1H34_22200	COG0629	single-stranded DNA binding
I1H34_22205	COG0151	Belongs to the GarS family
I1H34_22235	COG1131	(ABC) transporter
I1H34_22235	COG0842	Transport permease protein
I1H34_22235	COG1716	ATPase activity
I1H34_22240	COG2815	serine threonine protein kinase
I1H34_22240	COG0515	serine threonine protein kinase
I1H34_22245	COG1253	flavin adenine dinucleotide binding
I1H34_22250	COG1178	ABC-type Fe3 transport system permease component
I1H34_22255	COG0445	tRNA wobble uridine modification
I1H34_22280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1H34_22285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1H34_22305	COG0517	IMP dehydrogenase activity
I1H34_22305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I1H34_22310	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I1H34_22315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I1H34_22320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I1H34_22435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1H34_22450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I1H34_22470	COG2072	flavoprotein involved in K transport
I1H34_22475	COG5002	protein histidine kinase activity
I1H34_22475	COG5001	Diguanylate cyclase
I1H34_22505	COG2144	transferase activity, transferring acyl groups
I1H34_22515	COG0438	transferase activity, transferring glycosyl groups
I1H34_22525	COG2197	response regulator
I1H34_22545	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_22565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I1H34_22610	COG0625	glutathione transferase activity
I1H34_22650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I1H34_22675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I1H34_22680	COG1494	fructose-1,6-bisphosphatase
I1H34_22695	COG0583	DNA-binding transcription factor activity
I1H34_22705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I1H34_22705	COG0456	acetyltransferase
I1H34_22715	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I1H34_22725	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I1H34_22730	COG0156	8-amino-7-oxononanoate synthase activity
I1H34_22760	COG4172	Belongs to the ABC transporter superfamily
I1H34_22780	COG2988	succinylglutamate desuccinylase activity
I1H34_22790	COG0728	peptidoglycan biosynthetic process
I1H34_22800	COG5001	Diguanylate cyclase
I1H34_22800	COG1716	ATPase activity
I1H34_22805	COG4221	oxidoreductase activity
I1H34_22810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I1H34_22820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I1H34_22845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I1H34_22865	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I1H34_22880	COG0442	prolyl-tRNA aminoacylation
I1H34_22900	COG0387	Pfam Sodium calcium exchanger
I1H34_22920	COG0740	serine-type endopeptidase activity
I1H34_22925	COG0740	serine-type endopeptidase activity
I1H34_22955	COG0564	pseudouridine synthase activity
I1H34_22970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_22975	COG1489	DNA binding
I1H34_22985	COG0602	queuosine metabolic process
I1H34_22990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I1H34_23000	COG1040	competence protein
I1H34_23005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1H34_23005	COG0574	Belongs to the PEP-utilizing enzyme family
I1H34_23015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I1H34_23030	COG0739	heme binding
I1H34_23040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I1H34_23055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I1H34_23070	COG0714	Associated with various cellular activities
I1H34_23090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1H34_23095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I1H34_23100	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I1H34_23125	COG0631	protein serine/threonine phosphatase activity
I1H34_23145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I1H34_23170	COG1716	ATPase activity
I1H34_23170	COG5001	Diguanylate cyclase
I1H34_23240	COG2176	DNA-directed DNA polymerase activity
I1H34_23270	COG0583	DNA-binding transcription factor activity
I1H34_23275	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I1H34_23280	COG0563	adenylate kinase activity
I1H34_23285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I1H34_23290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I1H34_23300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I1H34_23315	COG2154	pterin-4-alpha-carbinolamine dehydratase
I1H34_23320	COG0357	Ribosomal RNA small subunit methyltransferase G
I1H34_23325	COG3128	pkhd-type hydroxylase
I1H34_23330	COG2319	Wd-40 repeat
I1H34_23330	COG4249	Peptidase C14 caspase catalytic subunit p20
I1H34_23335	COG0415	Belongs to the DNA photolyase family
I1H34_23350	COG3693	PFAM glycoside hydrolase, family 10
I1H34_23370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_23390	COG0443	Heat shock 70 kDa protein
I1H34_23415	COG4122	O-methyltransferase activity
I1H34_23450	COG0351	phosphomethylpyrimidine kinase
I1H34_23485	COG0456	acetyltransferase
I1H34_23490	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I1H34_23500	COG2885	chlorophyll binding
I1H34_23505	COG2885	chlorophyll binding
I1H34_23520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I1H34_23535	COG0312	modulator of DNA gyrase
I1H34_23540	COG0312	modulator of DNA gyrase
I1H34_23545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I1H34_23550	COG0438	transferase activity, transferring glycosyl groups
I1H34_23555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I1H34_23560	COG0438	transferase activity, transferring glycosyl groups
I1H34_23625	COG3001	Fructosamine kinase
I1H34_23645	COG1619	proteins homologs of microcin C7 resistance protein MccF
I1H34_23660	COG3118	belongs to the thioredoxin family
I1H34_23665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I1H34_23670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_23680	COG0714	Associated with various cellular activities
I1H34_23685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I1H34_23695	COG2205	protein histidine kinase activity
I1H34_23700	COG2319	Wd-40 repeat
I1H34_23700	COG1672	PFAM Archaeal ATPase
I1H34_23705	COG0515	serine threonine protein kinase
I1H34_23745	COG0587	DNA-directed DNA polymerase activity
I1H34_23750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I1H34_23755	COG4245	von Willebrand factor, type A
I1H34_23770	COG0860	N-Acetylmuramoyl-L-alanine amidase
I1H34_23780	COG0705	Rhomboid family
I1H34_23795	COG3335	DDE superfamily endonuclease
I1H34_23815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1H34_23820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I1H34_23825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I1H34_23845	COG0464	growth
I1H34_23875	COG0525	valine-tRNA ligase activity
I1H34_23880	COG0724	RNA recognition motif
I1H34_23885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I1H34_23890	COG1047	Peptidyl-prolyl cis-trans
I1H34_23905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I1H34_23905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I1H34_23910	COG0436	Aminotransferase
I1H34_23935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I1H34_23965	COG4447	cellulose binding
I1H34_23970	COG1773	rubredoxin
I1H34_23980	COG0012	GTP binding
I1H34_23985	COG1982	Orn Lys Arg decarboxylase major
I1H34_24000	COG0363	glucosamine-6-phosphate deaminase activity
I1H34_24005	COG1716	ATPase activity
I1H34_24010	COG2815	serine threonine protein kinase
I1H34_24010	COG0515	serine threonine protein kinase
I1H34_24030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I1H34_24045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I1H34_24045	COG4651	solute:proton antiporter activity
I1H34_24050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I1H34_24060	COG0196	riboflavin kinase activity
I1H34_24065	COG0714	Associated with various cellular activities
I1H34_24075	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I1H34_24080	COG1104	cysteine desulfurase activity
I1H34_24115	COG0739	heme binding
I1H34_24115	COG0741	lytic transglycosylase activity
I1H34_24115	COG1196	nuclear chromosome segregation
I1H34_24125	COG1716	ATPase activity
I1H34_24125	COG5001	Diguanylate cyclase
I1H34_24130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I1H34_24140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I1H34_24160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I1H34_24175	COG1252	NADH dehydrogenase
I1H34_24180	COG0450	alkyl hydroperoxide reductase
I1H34_24185	COG0463	Glycosyl transferase, family 2
I1H34_24200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I1H34_24220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1H34_24230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I1H34_24255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_24260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I1H34_24280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I1H34_24285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I1H34_24355	COG0784	Response regulator, receiver
I1H34_24355	COG2205	protein histidine kinase activity
I1H34_24355	COG2198	Histidine kinase
I1H34_24365	COG1595	DNA-templated transcription, initiation
I1H34_24410	COG0577	efflux transmembrane transporter activity
I1H34_24410	COG1136	(ABC) transporter
I1H34_24425	COG0358	DNA primase activity
I1H34_24430	COG3118	belongs to the thioredoxin family
I1H34_24435	COG1716	ATPase activity
I1H34_24445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I1H34_24445	COG0140	phosphoribosyl-ATP diphosphatase activity
I1H34_24455	COG1716	ATPase activity
I1H34_24455	COG1716	ATPase activity
I1H34_24460	COG0475	glutathione-regulated potassium exporter activity
I1H34_24460	COG0589	response to stress
I1H34_24470	COG0431	NADPH-dependent FMN reductase
I1H34_24490	COG1695	Transcriptional regulator
I1H34_24515	COG2852	Protein conserved in bacteria
I1H34_24530	COG2197	response regulator
I1H34_24540	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I1H34_24550	COG0393	Putative heavy-metal-binding
I1H34_24580	COG0247	lactate metabolic process
I1H34_24585	COG0277	FAD linked oxidase domain protein
I1H34_24600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I1H34_24620	COG2010	Cytochrome c
I1H34_24630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I1H34_24665	COG0497	DNA recombination
I1H34_24680	COG0237	dephospho-CoA kinase activity
I1H34_24685	COG2217	Heavy metal translocating P-type atpase
I1H34_24730	COG1053	succinate dehydrogenase
I1H34_24735	COG2165	general secretion pathway protein
I1H34_24745	COG1309	transcriptional regulator
I1H34_24750	COG4680	protein conserved in bacteria
I1H34_24760	COG2267	carboxylic ester hydrolase activity
I1H34_24765	COG2723	6-phospho-beta-galactosidase activity
I1H34_24770	COG0515	serine threonine protein kinase
I1H34_24770	COG3266	domain, Protein
I1H34_24785	COG1215	transferase activity, transferring glycosyl groups
I1H34_24795	COG2954	triphosphatase activity
I1H34_24805	COG5002	protein histidine kinase activity
I1H34_24810	COG1981	membrane
I1H34_24815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I1H34_24825	COG1196	nuclear chromosome segregation
I1H34_24835	COG2894	cell division
I1H34_24855	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I1H34_24860	COG3250	beta-galactosidase activity
I1H34_24865	COG3291	Pkd domain containing protein
I1H34_24870	COG1872	DUF167
I1H34_24885	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_24885	COG0515	serine threonine protein kinase
I1H34_24890	COG0515	serine threonine protein kinase
I1H34_24890	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_24915	COG0457	Tetratricopeptide repeat
I1H34_24940	COG0010	Belongs to the arginase family
I1H34_24945	COG0375	protein maturation
I1H34_24960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I1H34_24965	COG1116	anion transmembrane transporter activity
I1H34_24975	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I1H34_24980	COG3266	domain, Protein
I1H34_24980	COG0515	serine threonine protein kinase
I1H34_24995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I1H34_25020	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
I1H34_25045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I1H34_25050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I1H34_25060	COG0717	Belongs to the dCTP deaminase family
I1H34_25065	COG3751	2OG-Fe(II) oxygenase superfamily
I1H34_25070	COG2099	Precorrin-6x reductase
I1H34_25075	COG5001	Diguanylate cyclase
I1H34_25075	COG1716	ATPase activity
I1H34_25080	COG0335	large ribosomal subunit rRNA binding
I1H34_25090	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I1H34_25095	COG0250	Participates in transcription elongation, termination and antitermination
I1H34_25100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I1H34_25105	COG0081	regulation of translation
I1H34_25110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I1H34_25115	COG0222	ribosome binding
I1H34_25120	COG1799	cell septum assembly
I1H34_25135	COG1131	(ABC) transporter
I1H34_25135	COG1716	ATPase activity
I1H34_25135	COG0842	Transport permease protein
I1H34_25140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I1H34_25150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I1H34_25155	COG3409	Peptidoglycan-binding domain 1 protein
I1H34_25155	COG3429	Glucose-6-phosphate dehydrogenase subunit
I1H34_25165	COG1797	cobyrinic acid a,c-diamide synthase activity
I1H34_25175	COG0632	four-way junction helicase activity
I1H34_25195	COG0596	Alpha beta hydrolase
I1H34_25215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I1H34_25215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I1H34_25265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I1H34_25275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I1H34_25285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I1H34_25305	COG0163	prenyltransferase activity
I1H34_25315	COG0346	lactoylglutathione lyase activity
I1H34_25325	COG0504	CTP synthase activity
I1H34_25330	COG1940	carbohydrate kinase activity
I1H34_25335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I1H34_25365	COG1253	flavin adenine dinucleotide binding
I1H34_25375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I1H34_25420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I1H34_25440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I1H34_25445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I1H34_25455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I1H34_25470	COG2084	Dehydrogenase
I1H34_25480	COG0601	transmembrane transport
I1H34_25485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I1H34_25555	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_25555	COG0515	serine threonine protein kinase
I1H34_25560	COG1175	transmembrane transport
I1H34_25605	COG1131	(ABC) transporter
I1H34_25640	COG0038	chloride channel
I1H34_25650	COG1011	Hydrolase
I1H34_25680	COG2223	nitrite transmembrane transporter activity
I1H34_25685	COG3659	wide pore channel activity
I1H34_25690	COG0243	molybdopterin cofactor binding
I1H34_25695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I1H34_25700	COG0778	Nitroreductase
I1H34_25750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I1H34_25760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I1H34_25800	COG2166	iron-sulfur cluster assembly
I1H34_25850	COG3220	belongs to the UPF0276 family
I1H34_25880	COG0523	cobalamin synthesis protein
I1H34_25960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_25970	COG4451	ribulose bisphosphate carboxylase, small
I1H34_25970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I1H34_25985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I1H34_25990	COG0302	gtp cyclohydrolase
I1H34_25995	COG0523	cobalamin synthesis protein
I1H34_26055	COG0523	cobalamin synthesis protein
I1H34_26060	COG0113	porphobilinogen synthase activity
I1H34_26065	COG3443	Belongs to the bacterial solute-binding protein 9 family
I1H34_26065	COG0803	Belongs to the bacterial solute-binding protein 9 family
I1H34_26070	COG1121	(ABC) transporter
I1H34_26075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I1H34_26110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I1H34_26115	COG1472	Belongs to the glycosyl hydrolase 3 family
I1H34_26135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I1H34_26140	COG0321	lipoyl(octanoyl) transferase activity
I1H34_26145	COG0314	molybdopterin synthase activity
I1H34_26160	COG0706	membrane insertase activity
I1H34_26170	COG0594	ribonuclease P activity
I1H34_26175	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I1H34_26180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I1H34_26185	COG0592	DNA-directed DNA polymerase activity
I1H34_26200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I1H34_26200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I1H34_26210	COG1216	Glycosyl transferase, family 2
I1H34_26225	COG0463	Glycosyl transferase, family 2
I1H34_26230	COG0745	RESPONSE REGULATOR receiver
I1H34_26235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I1H34_26240	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I1H34_26245	COG2211	Major facilitator Superfamily
I1H34_26255	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_26265	COG1012	belongs to the aldehyde dehydrogenase family
I1H34_26275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I1H34_26290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I1H34_26305	COG4251	negative regulation of phosphorylation
I1H34_26320	COG1181	Belongs to the D-alanine--D-alanine ligase family
I1H34_26325	COG2027	D-alanyl-D-alanine carboxypeptidase
I1H34_26370	COG0681	Belongs to the peptidase S26 family
I1H34_26380	COG0129	dihydroxy-acid dehydratase activity
I1H34_26395	COG3903	Transcriptional regulator
I1H34_26395	COG2319	Wd-40 repeat
I1H34_26400	COG0824	Thioesterase
I1H34_26430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I1H34_26435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_26445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I1H34_26455	COG3842	ATPase activity
I1H34_26460	COG3266	domain, Protein
I1H34_26460	COG0515	serine threonine protein kinase
I1H34_26465	COG0629	single-stranded DNA binding
I1H34_26470	COG0628	permease
I1H34_26475	COG0752	glycyl-tRNA synthetase alpha subunit
I1H34_26505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I1H34_26520	COG0316	Belongs to the HesB IscA family
I1H34_26560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I1H34_26565	COG2274	protein secretion by the type I secretion system
I1H34_26585	COG0789	Transcriptional regulator
I1H34_26585	COG4978	Transcriptional regulator
I1H34_26600	COG3266	domain, Protein
I1H34_26600	COG0515	serine threonine protein kinase
I1H34_26620	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I1H34_26620	COG2273	Hydrolase Family 16
I1H34_26630	COG0438	transferase activity, transferring glycosyl groups
I1H34_26635	COG0659	secondary active sulfate transmembrane transporter activity
I1H34_26640	COG0475	glutathione-regulated potassium exporter activity
I1H34_26645	COG1006	Multisubunit Na H antiporter MnhC subunit
I1H34_26650	COG0651	ATP synthesis coupled electron transport
I1H34_26710	COG0459	protein refolding
I1H34_26730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_26745	COG0492	ferredoxin-NADP+ reductase activity
I1H34_26770	COG0745	RESPONSE REGULATOR receiver
I1H34_26775	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1H34_26780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I1H34_26785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_26795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_26800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I1H34_26800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I1H34_26805	COG0438	transferase activity, transferring glycosyl groups
I1H34_26810	COG2226	methyltransferase
I1H34_26820	COG1216	Glycosyl transferase, family 2
I1H34_26830	COG1132	(ABC) transporter
I1H34_26835	COG1442	glycosyl transferase family 8
I1H34_26835	COG1216	Glycosyl transferase, family 2
I1H34_26840	COG1215	transferase activity, transferring glycosyl groups
I1H34_26850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I1H34_26900	COG0668	transmembrane transport
I1H34_26910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26955	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_26960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_27015	COG4974	Belongs to the 'phage' integrase family
I1H34_27025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_27040	COG4974	Belongs to the 'phage' integrase family
I1H34_27080	COG1525	nuclease
I1H34_27140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I1H34_27155	COG1357	PFAM Pentapeptide repeats (8 copies)
I1H34_27155	COG0515	serine threonine protein kinase
I1H34_27180	COG0724	RNA recognition motif
I1H34_27190	COG0628	permease
I1H34_27225	COG0668	transmembrane transport
I1H34_27250	COG1077	Cell shape determining protein MreB Mrl
I1H34_27280	COG0189	ligase activity
I1H34_27280	COG4067	protein conserved in archaea
I1H34_27285	COG0189	ligase activity
I1H34_27310	COG2205	protein histidine kinase activity
I1H34_27315	COG0745	RESPONSE REGULATOR receiver
I1H34_27340	COG0071	Belongs to the small heat shock protein (HSP20) family
I1H34_27350	COG0589	response to stress
I1H34_27350	COG0475	glutathione-regulated potassium exporter activity
I1H34_27355	COG3273	potassium ion transport
I1H34_27355	COG0471	metal ion transport
I1H34_27360	COG1132	(ABC) transporter
I1H34_27375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_27380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_27390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_27405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I1H34_27410	COG2205	protein histidine kinase activity
I1H34_27410	COG0784	Response regulator, receiver
I1H34_27415	COG2197	response regulator
I1H34_27435	COG5001	Diguanylate cyclase
I1H34_27535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_27540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I1H34_27545	COG0668	transmembrane transport
I1H34_27550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I1H34_27550	COG3264	Mechanosensitive ion channel
I1H34_27555	COG0572	uridine kinase
I1H34_27560	COG2226	methyltransferase
I1H34_27570	COG1192	Involved in chromosome partitioning
I1H34_27575	COG1475	DNA binding
I1H34_27640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I1H34_27780	COG0776	regulation of translation
I1H34_27785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_27825	COG0784	Response regulator, receiver
I1H34_27850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_27935	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I1H34_28000	COG4221	oxidoreductase activity
I1H34_28030	COG4804	nuclease activity
I1H34_28040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I1H34_28155	COG0515	serine threonine protein kinase
I1H34_28155	COG2815	serine threonine protein kinase
I1H34_28230	COG1525	nuclease
I1H34_28235	COG1192	Involved in chromosome partitioning
I1H34_28270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1H34_28275	COG3629	intracellular signal transduction
I1H34_28275	COG3903	Transcriptional regulator
I1H34_28320	COG5001	Diguanylate cyclase
I1H34_28355	COG5002	protein histidine kinase activity
I1H34_28355	COG5001	Diguanylate cyclase
I1H34_28365	COG5001	Diguanylate cyclase
I1H34_28365	COG4251	negative regulation of phosphorylation
I1H34_28365	COG3706	GGDEF domain
I1H34_28365	COG2203	Gaf domain
I1H34_28370	COG3706	GGDEF domain
I1H34_28375	COG1716	ATPase activity
I1H34_28375	COG5001	Diguanylate cyclase
I1H34_28385	COG3437	response regulator, receiver
I1H34_28390	COG5002	protein histidine kinase activity
I1H34_28390	COG2198	Histidine kinase
I1H34_28390	COG0784	Response regulator, receiver
I1H34_28405	COG0724	RNA recognition motif
I1H34_28410	COG0724	RNA recognition motif
I1H34_28415	COG0542	response to heat
I1H34_28470	COG0724	RNA recognition motif
I1H34_28510	COG1716	ATPase activity
I1H34_28530	COG5002	protein histidine kinase activity
I1H34_28550	COG0724	RNA recognition motif
I1H34_28565	COG0724	RNA recognition motif
I1H34_28575	COG2124	cytochrome p450
I1H34_28600	COG0515	serine threonine protein kinase
I1H34_28605	COG3903	Transcriptional regulator
I1H34_28605	COG2319	Wd-40 repeat
I1H34_28645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_28690	COG4942	peptidase
I1H34_28690	COG1388	LysM domain
I1H34_28810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_28815	COG0776	regulation of translation
I1H34_28865	COG1413	lyase activity
I1H34_28880	COG3335	DDE superfamily endonuclease
I1H34_28890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_28900	COG0776	regulation of translation
I1H34_28935	COG4251	negative regulation of phosphorylation
I1H34_28935	COG5001	Diguanylate cyclase
I1H34_28935	COG3706	GGDEF domain
I1H34_28935	COG2203	Gaf domain
I1H34_29075	COG1475	DNA binding
I1H34_29080	COG1192	Involved in chromosome partitioning
I1H34_29095	COG4974	Belongs to the 'phage' integrase family
I1H34_29130	COG0789	Transcriptional regulator
I1H34_29140	COG5002	protein histidine kinase activity
I1H34_29170	COG0745	RESPONSE REGULATOR receiver
I1H34_29175	COG5002	protein histidine kinase activity
I1H34_29180	COG2273	Hydrolase Family 16
I1H34_29180	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I1H34_29210	COG3629	intracellular signal transduction
I1H34_29210	COG3903	Transcriptional regulator
I1H34_29335	COG1484	DNA-dependent DNA replication
I1H34_29340	COG1799	cell septum assembly
I1H34_29360	COG2319	Wd-40 repeat
I1H34_29360	COG4249	Peptidase C14 caspase catalytic subunit p20
I1H34_29400	COG0582	viral genome integration into host DNA
I1H34_29465	COG4974	Belongs to the 'phage' integrase family
I1H34_29505	COG0583	DNA-binding transcription factor activity
I1H34_29565	COG0651	ATP synthesis coupled electron transport
I1H34_29570	COG1006	Multisubunit Na H antiporter MnhC subunit
I1H34_29575	COG0475	glutathione-regulated potassium exporter activity
I1H34_29580	COG0347	Belongs to the P(II) protein family
I1H34_29595	COG5001	Diguanylate cyclase
I1H34_29595	COG5002	protein histidine kinase activity
I1H34_29600	COG5002	protein histidine kinase activity
I1H34_29600	COG5001	Diguanylate cyclase
I1H34_29610	COG5001	Diguanylate cyclase
I1H34_29610	COG4251	negative regulation of phosphorylation
I1H34_29610	COG3706	GGDEF domain
I1H34_29610	COG2203	Gaf domain
I1H34_29625	COG3437	response regulator, receiver
I1H34_29680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I1H34_29695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I1H34_29710	COG4584	PFAM Integrase catalytic
I1H34_29715	COG0515	serine threonine protein kinase
I1H34_29715	COG2815	serine threonine protein kinase
I1H34_29770	COG2423	ornithine cyclodeaminase activity
I1H34_29825	COG0724	RNA recognition motif
I1H34_29830	COG5002	protein histidine kinase activity
I1H34_29830	COG3447	MASE1 domain protein
I1H34_29830	COG5001	Diguanylate cyclase
I1H34_29840	COG0745	RESPONSE REGULATOR receiver
I1H34_29900	COG0745	RESPONSE REGULATOR receiver
I1H34_29920	COG0724	RNA recognition motif
I1H34_29930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_29990	COG2815	serine threonine protein kinase
I1H34_29990	COG0515	serine threonine protein kinase
I1H34_30010	COG3335	DDE superfamily endonuclease
I1H34_30075	COG1799	cell septum assembly
I1H34_30110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I1H34_30170	COG0589	response to stress
I1H34_30190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1H34_30215	COG0726	polysaccharide deacetylase
I1H34_30235	COG3344	reverse transcriptase
I1H34_30245	COG1061	Type III restriction enzyme res subunit
I1H34_30255	COG5002	protein histidine kinase activity
I1H34_30260	COG0745	RESPONSE REGULATOR receiver
I1H34_30265	COG0745	RESPONSE REGULATOR receiver
I1H34_30275	COG2205	protein histidine kinase activity
I1H34_30365	COG1192	Involved in chromosome partitioning
I1H34_30370	COG1475	DNA binding
I1H34_30375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I1H34_30375	COG0674	pyruvate-flavodoxin oxidoreductase activity
I1H34_30375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I1H34_30375	COG1013	pyruvate-flavodoxin oxidoreductase activity
I1H34_30385	COG3453	Protein conserved in bacteria
I1H34_30385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I1H34_30390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I1H34_30440	COG0693	protein deglycase activity
I1H34_30445	COG2226	methyltransferase
I1H34_30465	COG0702	epimerase
I1H34_30480	COG0589	response to stress
I1H34_30520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I1H34_30545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_30550	COG0058	SHG alpha-glucan phosphorylase activity
I1H34_30560	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I1H34_30580	COG0375	protein maturation
I1H34_30585	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I1H34_30605	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I1H34_30610	COG0298	carbon dioxide binding
I1H34_30615	COG3259	Nickel-dependent hydrogenase
I1H34_30630	COG0517	IMP dehydrogenase activity
I1H34_30635	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I1H34_30640	COG1034	ATP synthesis coupled electron transport
I1H34_30665	COG0589	response to stress
I1H34_30670	COG0589	response to stress
I1H34_30695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I1H34_30725	COG0475	glutathione-regulated potassium exporter activity
I1H34_30745	COG0574	Belongs to the PEP-utilizing enzyme family
I1H34_30745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I1H34_30750	COG4251	negative regulation of phosphorylation
I1H34_30755	COG2205	protein histidine kinase activity
I1H34_30755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I1H34_30800	COG0071	Belongs to the small heat shock protein (HSP20) family
I1H34_30810	COG3335	DDE superfamily endonuclease
I1H34_30820	COG2267	carboxylic ester hydrolase activity
I1H34_30840	COG0183	Belongs to the thiolase family
I1H34_30845	COG1960	acyl-CoA dehydrogenase activity
I1H34_30855	COG0409	Hydrogenase expression formation protein
I1H34_30860	COG0205	6-phosphofructokinase activity
I1H34_31025	COG1028	Short-chain dehydrogenase reductase Sdr
I1H34_31040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_31055	COG2815	serine threonine protein kinase
I1H34_31055	COG0515	serine threonine protein kinase
I1H34_31155	COG1192	Involved in chromosome partitioning
I1H34_31190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I1H34_31195	COG3629	intracellular signal transduction
I1H34_31195	COG3903	Transcriptional regulator
I1H34_31215	COG4974	Belongs to the 'phage' integrase family
I1H34_31235	COG1061	Type III restriction enzyme res subunit
I1H34_31295	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I1H34_31300	COG0724	RNA recognition motif
I1H34_31305	COG0517	IMP dehydrogenase activity
I1H34_31315	COG0745	RESPONSE REGULATOR receiver
I1H34_31330	COG0318	PFAM AMP-dependent synthetase and ligase
I1H34_31345	COG1960	acyl-CoA dehydrogenase activity
I1H34_31390	COG4974	Belongs to the 'phage' integrase family
I1H34_31415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_31425	COG0776	regulation of translation
I1H34_31465	COG3093	addiction module antidote protein HigA
I1H34_31485	COG1799	cell septum assembly
I1H34_31495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I1H34_31500	COG0776	regulation of translation
I1H34_31565	COG3328	transposase activity
I1H34_31600	COG1799	cell septum assembly
I1H34_31630	COG1799	cell septum assembly
I1H34_31635	COG0724	RNA recognition motif
I1H34_31645	COG1476	TRANSCRIPTIONal
I1H34_31675	COG2319	Wd-40 repeat
I1H34_31675	COG4249	Peptidase C14 caspase catalytic subunit p20
I1H34_31855	COG3093	addiction module antidote protein HigA