locus-tag	class	description
HRE53_00010	COG3335	DDE superfamily endonuclease
HRE53_00070	COG0517	IMP dehydrogenase activity
HRE53_00070	COG0516	GMP reductase activity
HRE53_00080	COG0616	signal peptide processing
HRE53_00085	COG0697	spore germination
HRE53_00105	COG5002	protein histidine kinase activity
HRE53_00115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HRE53_00135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRE53_00135	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HRE53_00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRE53_00180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRE53_00190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRE53_00205	COG3659	wide pore channel activity
HRE53_00215	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_00220	COG0802	atpase or kinase
HRE53_00280	COG1217	gtp-binding protein TYPA
HRE53_00285	COG5002	protein histidine kinase activity
HRE53_00285	COG0784	Response regulator, receiver
HRE53_00290	COG3706	GGDEF domain
HRE53_00290	COG4251	negative regulation of phosphorylation
HRE53_00290	COG5001	Diguanylate cyclase
HRE53_00290	COG2203	Gaf domain
HRE53_00295	COG0432	Pfam Uncharacterised protein family UPF0047
HRE53_00300	COG1840	ABC-type Fe3 transport system, periplasmic component
HRE53_00305	COG3264	Mechanosensitive ion channel
HRE53_00305	COG1196	nuclear chromosome segregation
HRE53_00320	COG0598	Magnesium transport protein CorA
HRE53_00335	COG0457	Tetratricopeptide repeat
HRE53_00335	COG0705	Rhomboid family
HRE53_00345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRE53_00385	COG3536	Protein conserved in bacteria
HRE53_00390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRE53_00405	COG0315	cyclic pyranopterin monophosphate synthase activity
HRE53_00430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRE53_00440	COG1595	DNA-templated transcription, initiation
HRE53_00460	COG0513	Belongs to the DEAD box helicase family
HRE53_00465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_00470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_00475	COG1260	myo-inositol-1-phosphate synthase
HRE53_00490	COG0837	glucose binding
HRE53_00495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE53_00505	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HRE53_00505	COG3291	Pkd domain containing protein
HRE53_00525	COG0672	)-iron permease
HRE53_00575	COG0436	Aminotransferase
HRE53_00580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_00595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRE53_00605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRE53_00620	COG2226	methyltransferase
HRE53_00645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRE53_00665	COG0072	phenylalanine-tRNA ligase activity
HRE53_00755	COG4251	negative regulation of phosphorylation
HRE53_00760	COG0784	Response regulator, receiver
HRE53_00765	COG2204	response regulator
HRE53_00770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRE53_00775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_00815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_00840	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HRE53_00860	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRE53_00860	COG3608	succinylglutamate desuccinylase aspartoacylase
HRE53_00875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRE53_00910	COG1943	Transposase
HRE53_00925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_00930	COG0573	inorganic phosphate transmembrane transporter activity
HRE53_00935	COG0581	inorganic phosphate transmembrane transporter activity
HRE53_00940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRE53_00950	COG3903	Transcriptional regulator
HRE53_00950	COG2319	Wd-40 repeat
HRE53_00960	COG3328	transposase activity
HRE53_00980	COG0175	sulfate reduction
HRE53_01005	COG5285	phytanoyl-CoA dioxygenase
HRE53_01030	COG5433	transposase activity
HRE53_01045	COG0438	transferase activity, transferring glycosyl groups
HRE53_01080	COG1132	(ABC) transporter
HRE53_01115	COG0489	protein tyrosine kinase activity
HRE53_01130	COG0745	RESPONSE REGULATOR receiver
HRE53_01165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRE53_01185	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRE53_01190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRE53_01200	COG0019	diaminopimelate decarboxylase activity
HRE53_01205	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HRE53_01220	COG0484	heat shock protein binding
HRE53_01225	COG1459	type II secretion system
HRE53_01235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRE53_01240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_01245	COG0443	Heat shock 70 kDa protein
HRE53_01250	COG0484	heat shock protein binding
HRE53_01260	COG1162	GTPase activity
HRE53_01280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRE53_01285	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRE53_01315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRE53_01335	COG0515	serine threonine protein kinase
HRE53_01365	COG0022	dehydrogenase e1 component
HRE53_01365	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRE53_01370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRE53_01375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRE53_01450	COG0390	transport system, permease component
HRE53_01460	COG1994	Peptidase M50
HRE53_01465	COG0484	heat shock protein binding
HRE53_01480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE53_01515	COG1125	glycine betaine transport
HRE53_01515	COG0517	IMP dehydrogenase activity
HRE53_01520	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_01525	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_01535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRE53_01540	COG0416	fatty acid biosynthetic process
HRE53_01550	COG4399	Belongs to the UPF0754 family
HRE53_01555	COG1131	(ABC) transporter
HRE53_01560	COG0631	protein serine/threonine phosphatase activity
HRE53_01565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRE53_01570	COG3937	granule-associated protein
HRE53_01575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRE53_01590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRE53_01590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRE53_01615	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HRE53_01630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRE53_01630	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRE53_01655	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_01660	COG0463	Glycosyl transferase, family 2
HRE53_01660	COG1216	Glycosyl transferase, family 2
HRE53_01665	COG2244	polysaccharide biosynthetic process
HRE53_01705	COG1429	ligase activity, forming nitrogen-metal bonds
HRE53_01715	COG1022	Amp-dependent synthetase and ligase
HRE53_01730	COG0482	sulfurtransferase activity
HRE53_01735	COG0724	RNA recognition motif
HRE53_01740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRE53_01745	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRE53_01760	COG0793	Belongs to the peptidase S41A family
HRE53_01770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRE53_01780	COG0438	transferase activity, transferring glycosyl groups
HRE53_01785	COG0438	transferase activity, transferring glycosyl groups
HRE53_01795	COG0297	glycogen (starch) synthase activity
HRE53_01810	COG1234	tRNA 3'-trailer cleavage
HRE53_01835	COG5002	protein histidine kinase activity
HRE53_01870	COG0556	nucleotide-excision repair
HRE53_01875	COG2205	protein histidine kinase activity
HRE53_01885	COG2048	Heterodisulfide reductase, subunit B
HRE53_01895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE53_01900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRE53_01905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRE53_01915	COG0346	lactoylglutathione lyase activity
HRE53_01940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRE53_01950	COG0193	aminoacyl-tRNA hydrolase activity
HRE53_01955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRE53_01975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HRE53_01985	COG0233	cytoplasmic translational termination
HRE53_01990	COG0528	UMP kinase activity
HRE53_02005	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRE53_02050	COG0668	transmembrane transport
HRE53_02075	COG0577	efflux transmembrane transporter activity
HRE53_02075	COG1136	(ABC) transporter
HRE53_02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_02090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_02100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRE53_02120	COG2205	protein histidine kinase activity
HRE53_02140	COG2217	Heavy metal translocating P-type atpase
HRE53_02165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRE53_02170	COG0469	pyruvate kinase activity
HRE53_02175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRE53_02180	COG0625	glutathione transferase activity
HRE53_02205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRE53_02215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRE53_02255	COG0195	Participates in both transcription termination and antitermination
HRE53_02260	COG0779	Required for maturation of 30S ribosomal subunits
HRE53_02275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRE53_02280	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HRE53_02320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRE53_02325	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRE53_02335	COG0004	ammonium transporteR
HRE53_02350	COG0784	Response regulator, receiver
HRE53_02350	COG2198	Histidine kinase
HRE53_02350	COG0643	Histidine kinase
HRE53_02355	COG0840	transmembrane signaling receptor activity
HRE53_02355	COG2203	Gaf domain
HRE53_02370	COG0784	Response regulator, receiver
HRE53_02380	COG0066	3-isopropylmalate dehydratase activity
HRE53_02395	COG4636	protein conserved in cyanobacteria
HRE53_02400	COG0473	3-isopropylmalate dehydrogenase activity
HRE53_02410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRE53_02415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRE53_02420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRE53_02425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRE53_02430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRE53_02440	COG0356	it plays a direct role in the translocation of protons across the membrane
HRE53_02465	COG2226	methyltransferase
HRE53_02490	COG0175	sulfate reduction
HRE53_02495	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRE53_02510	COG0830	nickel cation binding
HRE53_02515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRE53_02520	COG3659	wide pore channel activity
HRE53_02530	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRE53_02550	COG0625	glutathione transferase activity
HRE53_02555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRE53_02560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRE53_02585	COG5398	heme oxygenase
HRE53_02590	COG1970	mechanosensitive ion channel activity
HRE53_02595	COG0275	rRNA processing
HRE53_02605	COG0768	penicillin binding
HRE53_02610	COG3011	Protein conserved in bacteria
HRE53_02620	COG0612	Peptidase, M16
HRE53_02640	COG1233	COG1233 Phytoene dehydrogenase and related
HRE53_02660	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HRE53_02670	COG0745	RESPONSE REGULATOR receiver
HRE53_02680	COG0484	heat shock protein binding
HRE53_02685	COG2124	cytochrome p450
HRE53_02695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE53_02705	COG1309	transcriptional regulator
HRE53_02710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_02715	COG1122	ATPase activity
HRE53_02725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRE53_02730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRE53_02750	COG0438	transferase activity, transferring glycosyl groups
HRE53_02765	COG0431	NADPH-dependent FMN reductase
HRE53_02780	COG0745	RESPONSE REGULATOR receiver
HRE53_02790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRE53_02790	COG0646	methionine synthase
HRE53_02795	COG1615	UPF0182 protein
HRE53_02825	COG1515	deoxyribonuclease V activity
HRE53_02830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRE53_02885	COG0300	oxidoreductase activity
HRE53_02895	COG0156	8-amino-7-oxononanoate synthase activity
HRE53_02900	COG4221	oxidoreductase activity
HRE53_02900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRE53_02900	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_02900	COG3321	synthase
HRE53_02925	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_02950	COG2258	MOSC domain
HRE53_02995	COG4149	molybdate abc transporter
HRE53_03000	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRE53_03015	COG2363	Small membrane protein
HRE53_03025	COG0724	RNA recognition motif
HRE53_03035	COG2205	protein histidine kinase activity
HRE53_03035	COG5002	protein histidine kinase activity
HRE53_03035	COG0784	Response regulator, receiver
HRE53_03085	COG0564	pseudouridine synthase activity
HRE53_03190	COG0814	amino acid
HRE53_03195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRE53_03205	COG0587	DNA-directed DNA polymerase activity
HRE53_03230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRE53_03235	COG2226	methyltransferase
HRE53_03245	COG1446	asparaginase
HRE53_03265	COG2095	MarC family integral membrane protein
HRE53_03300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_03310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRE53_03325	COG1054	Belongs to the UPF0176 family
HRE53_03350	COG0277	FAD linked oxidase domain protein
HRE53_03355	COG1799	cell septum assembly
HRE53_03360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRE53_03380	COG1968	undecaprenyl-diphosphatase activity
HRE53_03390	COG0024	Methionine aminopeptidase
HRE53_03405	COG0424	maF-like protein
HRE53_03470	COG0495	leucyl-tRNA aminoacylation
HRE53_03515	COG1216	Glycosyl transferase, family 2
HRE53_03545	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_03545	COG0515	serine threonine protein kinase
HRE53_03550	COG0640	Transcriptional regulator
HRE53_03560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRE53_03575	COG1126	abc transporter atp-binding protein
HRE53_03580	COG0765	amino acid transport
HRE53_03585	COG4597	amino acid ABC transporter
HRE53_03590	COG0517	IMP dehydrogenase activity
HRE53_03590	COG0617	tRNA 3'-terminal CCA addition
HRE53_03590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRE53_03600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRE53_03610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRE53_03630	COG1045	serine acetyltransferase
HRE53_03645	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRE53_03660	COG4251	negative regulation of phosphorylation
HRE53_03665	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HRE53_03670	COG0463	Glycosyl transferase, family 2
HRE53_03670	COG0457	Tetratricopeptide repeat
HRE53_03695	COG1136	(ABC) transporter
HRE53_03735	COG4372	Transposase
HRE53_03750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRE53_03765	COG1191	sigma factor activity
HRE53_03775	COG0657	acetylesterase activity
HRE53_03805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_03815	COG2197	response regulator
HRE53_03840	COG0681	Belongs to the peptidase S26 family
HRE53_03860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRE53_03865	COG3706	GGDEF domain
HRE53_03865	COG2203	Gaf domain
HRE53_03865	COG5001	Diguanylate cyclase
HRE53_03865	COG4251	negative regulation of phosphorylation
HRE53_03875	COG3457	Alanine racemase
HRE53_03885	COG0724	RNA recognition motif
HRE53_03890	COG0724	RNA recognition motif
HRE53_03920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRE53_03945	COG1192	Involved in chromosome partitioning
HRE53_03950	COG0583	DNA-binding transcription factor activity
HRE53_03965	COG0501	Belongs to the peptidase M48B family
HRE53_03975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRE53_03985	COG4251	negative regulation of phosphorylation
HRE53_03985	COG3706	GGDEF domain
HRE53_03985	COG5001	Diguanylate cyclase
HRE53_03985	COG2203	Gaf domain
HRE53_04015	COG3541	Predicted nucleotidyltransferase
HRE53_04030	COG0840	transmembrane signaling receptor activity
HRE53_04050	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRE53_04060	COG1575	Belongs to the MenA family. Type 1 subfamily
HRE53_04065	COG0484	heat shock protein binding
HRE53_04070	COG0702	epimerase
HRE53_04075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRE53_04085	COG0322	excinuclease ABC activity
HRE53_04090	COG0297	glycogen (starch) synthase activity
HRE53_04100	COG1309	transcriptional regulator
HRE53_04130	COG3328	transposase activity
HRE53_04145	COG0735	belongs to the Fur family
HRE53_04180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRE53_04190	COG1420	regulation of RNA biosynthetic process
HRE53_04210	COG0582	viral genome integration into host DNA
HRE53_04220	COG0582	viral genome integration into host DNA
HRE53_04260	COG0776	regulation of translation
HRE53_04265	COG0575	Belongs to the CDS family
HRE53_04275	COG0745	RESPONSE REGULATOR receiver
HRE53_04285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRE53_04290	COG1051	belongs to the nudix hydrolase family
HRE53_04295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_04310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE53_04345	COG1331	Highly conserved protein containing a thioredoxin domain
HRE53_04370	COG1671	Belongs to the UPF0178 family
HRE53_04390	COG0625	glutathione transferase activity
HRE53_04405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_04405	COG2205	protein histidine kinase activity
HRE53_04410	COG2198	Histidine kinase
HRE53_04410	COG0784	Response regulator, receiver
HRE53_04410	COG2205	protein histidine kinase activity
HRE53_04425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRE53_04470	COG0523	cobalamin synthesis protein
HRE53_04510	COG2319	Wd-40 repeat
HRE53_04510	COG5635	Nacht domain
HRE53_04525	COG1252	NADH dehydrogenase
HRE53_04535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRE53_04570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRE53_04575	COG0719	Fe-S assembly protein
HRE53_04580	COG0396	ATPase activity
HRE53_04585	COG0719	Fe-S assembly protein
HRE53_04615	COG1309	transcriptional regulator
HRE53_04650	COG3328	transposase activity
HRE53_04660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRE53_04665	COG1376	ErfK ybiS ycfS ynhG family protein
HRE53_04670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRE53_04675	COG0254	rRNA binding
HRE53_04680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRE53_04685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRE53_04690	COG0101	tRNA pseudouridine synthase activity
HRE53_04695	COG0203	ribosomal protein L17
HRE53_04700	COG0202	RNA polymerase activity
HRE53_04705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRE53_04710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRE53_04715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRE53_04720	COG0646	methionine synthase
HRE53_04720	COG1410	methionine synthase
HRE53_04760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_04775	COG2827	Endonuclease containing a URI domain
HRE53_04830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRE53_04835	COG2264	protein methyltransferase activity
HRE53_04875	COG1361	Conserved repeat domain
HRE53_04875	COG2911	Protein conserved in bacteria
HRE53_04875	COG3266	domain, Protein
HRE53_04880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRE53_04885	COG4956	integral membrane protein (PIN domain superfamily)
HRE53_04895	COG0159	tryptophan synthase activity
HRE53_04910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRE53_04920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRE53_04940	COG4584	PFAM Integrase catalytic
HRE53_04945	COG1484	DNA-dependent DNA replication
HRE53_04965	COG0606	chelatase, subunit chli
HRE53_04970	COG3063	Type IV pilus biogenesis stability protein PilW
HRE53_04975	COG4172	Belongs to the ABC transporter superfamily
HRE53_04980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_04990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRE53_05015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_05020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRE53_05025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRE53_05030	COG0339	signal peptide processing
HRE53_05035	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_05035	COG0515	serine threonine protein kinase
HRE53_05040	COG0840	transmembrane signaling receptor activity
HRE53_05040	COG2203	Gaf domain
HRE53_05045	COG0784	Response regulator, receiver
HRE53_05045	COG2205	protein histidine kinase activity
HRE53_05055	COG0303	'Molybdopterin
HRE53_05065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRE53_05065	COG0426	domain, Protein
HRE53_05075	COG0426	domain, Protein
HRE53_05075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRE53_05090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRE53_05110	COG0114	fumarate hydratase activity
HRE53_05135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRE53_05140	COG1196	nuclear chromosome segregation
HRE53_05140	COG3264	Mechanosensitive ion channel
HRE53_05150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRE53_05155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRE53_05175	COG1473	amidohydrolase
HRE53_05205	COG2308	Evidence 4 Homologs of previously reported genes of
HRE53_05210	COG5002	protein histidine kinase activity
HRE53_05210	COG5001	Diguanylate cyclase
HRE53_05215	COG0709	Synthesizes selenophosphate from selenide and ATP
HRE53_05255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_05260	COG2319	Wd-40 repeat
HRE53_05260	COG3903	Transcriptional regulator
HRE53_05265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_05270	COG0546	phosphoglycolate phosphatase activity
HRE53_05285	COG0512	Glutamine amidotransferase of anthranilate synthase
HRE53_05290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRE53_05295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRE53_05305	COG0047	phosphoribosylformylglycinamidine synthase activity
HRE53_05310	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRE53_05315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRE53_05325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRE53_05325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRE53_05340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRE53_05355	COG1278	Cold shock
HRE53_05360	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HRE53_05365	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HRE53_05375	COG0489	protein tyrosine kinase activity
HRE53_05380	COG0772	Belongs to the SEDS family
HRE53_05395	COG0539	negative regulation of cytoplasmic translation
HRE53_05400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRE53_05415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE53_05435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRE53_05450	COG0071	Belongs to the small heat shock protein (HSP20) family
HRE53_05470	COG2161	toxin-antitoxin pair type II binding
HRE53_05475	COG4115	mRNA cleavage
HRE53_05480	COG1233	COG1233 Phytoene dehydrogenase and related
HRE53_05500	COG0745	RESPONSE REGULATOR receiver
HRE53_05530	COG0762	integral membrane protein
HRE53_05535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRE53_05550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRE53_05560	COG0174	glutamine synthetase
HRE53_05570	COG0784	Response regulator, receiver
HRE53_05570	COG5002	protein histidine kinase activity
HRE53_05595	COG2239	Acts as a magnesium transporter
HRE53_05605	COG0191	fructose-bisphosphate aldolase activity
HRE53_05610	COG0739	heme binding
HRE53_05615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRE53_05620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HRE53_05630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRE53_05700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRE53_05705	COG1063	alcohol dehydrogenase
HRE53_05715	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HRE53_05720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRE53_05730	COG0509	glycine decarboxylation via glycine cleavage system
HRE53_05735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRE53_05785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HRE53_05790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRE53_05830	COG1733	regulation of RNA biosynthetic process
HRE53_05835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_05845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE53_05850	COG1121	(ABC) transporter
HRE53_05855	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRE53_05865	COG2205	protein histidine kinase activity
HRE53_05865	COG0784	Response regulator, receiver
HRE53_05865	COG2198	Histidine kinase
HRE53_05895	COG2226	methyltransferase
HRE53_05935	COG3328	transposase activity
HRE53_05940	COG0515	serine threonine protein kinase
HRE53_05940	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_05945	COG1216	Glycosyl transferase, family 2
HRE53_05995	COG0515	serine threonine protein kinase
HRE53_05995	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_06000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_06015	COG1136	(ABC) transporter
HRE53_06045	COG0604	alcohol dehydrogenase
HRE53_06050	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRE53_06050	COG1024	Enoyl-CoA hydratase
HRE53_06055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRE53_06060	COG4221	oxidoreductase activity
HRE53_06080	COG2203	Gaf domain
HRE53_06080	COG5001	Diguanylate cyclase
HRE53_06080	COG4251	negative regulation of phosphorylation
HRE53_06080	COG3706	GGDEF domain
HRE53_06105	COG0135	phosphoribosylanthranilate isomerase activity
HRE53_06110	COG0167	dihydroorotate dehydrogenase activity
HRE53_06125	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRE53_06135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRE53_06135	COG0574	Belongs to the PEP-utilizing enzyme family
HRE53_06140	COG0589	response to stress
HRE53_06175	COG3854	ATPases associated with a variety of cellular activities
HRE53_06185	COG5002	protein histidine kinase activity
HRE53_06190	COG5002	protein histidine kinase activity
HRE53_06245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_06255	COG0069	glutamate synthase activity
HRE53_06255	COG0067	glutamate synthase
HRE53_06255	COG0070	glutamate synthase
HRE53_06260	COG0784	Response regulator, receiver
HRE53_06260	COG2198	Histidine kinase
HRE53_06260	COG5002	protein histidine kinase activity
HRE53_06265	COG3437	response regulator, receiver
HRE53_06275	COG0121	glutamine amidotransferase
HRE53_06290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRE53_06295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRE53_06310	COG0454	-acetyltransferase
HRE53_06330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRE53_06335	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HRE53_06345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRE53_06360	COG1032	radical SAM domain protein
HRE53_06380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRE53_06385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRE53_06400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRE53_06405	COG0513	Belongs to the DEAD box helicase family
HRE53_06415	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HRE53_06420	COG1530	ribonuclease E activity
HRE53_06425	COG0412	Dienelactone hydrolase
HRE53_06430	COG1725	Transcriptional regulator
HRE53_06435	COG2304	oxidoreductase activity
HRE53_06450	COG0612	Peptidase, M16
HRE53_06470	COG0571	ribonuclease III activity
HRE53_06475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRE53_06480	COG0484	heat shock protein binding
HRE53_06485	COG0037	tRNA processing
HRE53_06515	COG0784	Response regulator, receiver
HRE53_06520	COG4251	negative regulation of phosphorylation
HRE53_06525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRE53_06550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRE53_06560	COG0180	Tryptophanyl-tRNA synthetase
HRE53_06575	COG0285	dihydrofolate synthase activity
HRE53_06600	COG1132	(ABC) transporter
HRE53_06605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRE53_06610	COG2010	Cytochrome c
HRE53_06630	COG1819	glycosyl
HRE53_06645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRE53_06650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRE53_06675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_06710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRE53_06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_06735	COG0243	molybdopterin cofactor binding
HRE53_06760	COG4451	ribulose bisphosphate carboxylase, small
HRE53_06770	COG1850	ribulose-bisphosphate carboxylase activity
HRE53_06780	COG0454	-acetyltransferase
HRE53_06795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRE53_06815	COG0051	transcription antitermination factor activity, RNA binding
HRE53_06820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRE53_06825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRE53_06830	COG0049	tRNA binding
HRE53_06835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRE53_06840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRE53_06845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRE53_06850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRE53_06880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRE53_06885	COG0745	RESPONSE REGULATOR receiver
HRE53_06895	COG1333	cytochrome c biogenesis protein
HRE53_06905	COG0772	Belongs to the SEDS family
HRE53_06920	COG3659	wide pore channel activity
HRE53_06940	COG0783	Belongs to the Dps family
HRE53_06945	COG1136	(ABC) transporter
HRE53_06985	COG0659	secondary active sulfate transmembrane transporter activity
HRE53_06990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_06995	COG2217	Heavy metal translocating P-type atpase
HRE53_07015	COG2321	neutral zinc metallopeptidase
HRE53_07055	COG1174	glycine betaine transport
HRE53_07070	COG0217	transcriptional regulatory protein
HRE53_07080	COG2884	Cell division ATP-binding protein ftsE
HRE53_07085	COG2177	Part of the ABC transporter FtsEX involved in
HRE53_07105	COG0515	serine threonine protein kinase
HRE53_07140	COG1666	GTP binding
HRE53_07145	COG1012	belongs to the aldehyde dehydrogenase family
HRE53_07160	COG0516	GMP reductase activity
HRE53_07165	COG3118	belongs to the thioredoxin family
HRE53_07195	COG0693	protein deglycase activity
HRE53_07230	COG0436	Aminotransferase
HRE53_07245	COG0540	Belongs to the ATCase OTCase family
HRE53_07255	COG1122	ATPase activity
HRE53_07290	COG3594	Acyltransferase
HRE53_07310	COG0438	transferase activity, transferring glycosyl groups
HRE53_07315	COG0438	transferase activity, transferring glycosyl groups
HRE53_07315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRE53_07320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_07355	COG2244	polysaccharide biosynthetic process
HRE53_07385	COG0367	asparagine synthase
HRE53_07390	COG2850	peptidyl-arginine hydroxylation
HRE53_07395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HRE53_07420	COG1473	amidohydrolase
HRE53_07430	COG1397	ADP-ribosylglycohydrolase
HRE53_07440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRE53_07445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRE53_07465	COG0360	Binds together with S18 to 16S ribosomal RNA
HRE53_07470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HRE53_07490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRE53_07515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRE53_07520	COG0488	(ABC) transporter
HRE53_07530	COG0456	acetyltransferase
HRE53_07530	COG0454	-acetyltransferase
HRE53_07535	COG0542	response to heat
HRE53_07550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRE53_07565	COG0037	tRNA processing
HRE53_07605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_07610	COG0745	RESPONSE REGULATOR receiver
HRE53_07620	COG1858	cytochrome C peroxidase
HRE53_07625	COG2205	protein histidine kinase activity
HRE53_07625	COG0784	Response regulator, receiver
HRE53_07645	COG0434	BtpA family
HRE53_07650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_07655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRE53_07675	COG3596	GTP binding
HRE53_07700	COG0307	riboflavin synthase, alpha
HRE53_07725	COG3220	belongs to the UPF0276 family
HRE53_07775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRE53_07805	COG1233	COG1233 Phytoene dehydrogenase and related
HRE53_07835	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HRE53_07850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRE53_07865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRE53_07880	COG0017	Asparaginyl-tRNA synthetase
HRE53_07890	COG0297	glycogen (starch) synthase activity
HRE53_07895	COG0724	RNA recognition motif
HRE53_07920	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRE53_07925	COG3977	Valine--pyruvate aminotransferase
HRE53_07955	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRE53_07985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRE53_07990	COG1007	ATP synthesis coupled electron transport
HRE53_08010	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRE53_08015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRE53_08025	COG0742	ribosomal rna small subunit methyltransferase
HRE53_08075	COG0443	Heat shock 70 kDa protein
HRE53_08085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_08090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRE53_08095	COG0460	homoserine dehydrogenase
HRE53_08105	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HRE53_08110	COG0456	acetyltransferase
HRE53_08125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRE53_08130	COG0616	signal peptide processing
HRE53_08160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRE53_08180	COG0793	Belongs to the peptidase S41A family
HRE53_08190	COG0747	negative chemotaxis
HRE53_08195	COG1858	cytochrome C peroxidase
HRE53_08200	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HRE53_08210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRE53_08230	COG3335	DDE superfamily endonuclease
HRE53_08245	COG1640	4-alpha-glucanotransferase
HRE53_08270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_08275	COG0735	belongs to the Fur family
HRE53_08285	COG0572	uridine kinase
HRE53_08290	COG0058	SHG alpha-glucan phosphorylase activity
HRE53_08295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRE53_08305	COG2267	carboxylic ester hydrolase activity
HRE53_08310	COG0440	acetolactate synthase activity
HRE53_08330	COG0439	Biotin carboxylase
HRE53_08340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRE53_08345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRE53_08350	COG0542	response to heat
HRE53_08360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_08370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_08380	COG0475	glutathione-regulated potassium exporter activity
HRE53_08390	COG0039	L-malate dehydrogenase activity
HRE53_08440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRE53_08440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRE53_08465	COG2062	phosphohistidine phosphatase, SixA
HRE53_08470	COG0372	Belongs to the citrate synthase family
HRE53_08475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRE53_08480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_08500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRE53_08540	COG0629	single-stranded DNA binding
HRE53_08545	COG0151	Belongs to the GarS family
HRE53_08575	COG0842	Transport permease protein
HRE53_08575	COG1131	(ABC) transporter
HRE53_08575	COG1716	ATPase activity
HRE53_08580	COG2815	serine threonine protein kinase
HRE53_08580	COG0515	serine threonine protein kinase
HRE53_08585	COG1253	flavin adenine dinucleotide binding
HRE53_08590	COG1178	ABC-type Fe3 transport system permease component
HRE53_08595	COG0445	tRNA wobble uridine modification
HRE53_08620	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_08625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_08645	COG0517	IMP dehydrogenase activity
HRE53_08645	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRE53_08650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRE53_08660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRE53_08780	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_08790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRE53_08810	COG2072	flavoprotein involved in K transport
HRE53_08815	COG5002	protein histidine kinase activity
HRE53_08815	COG5001	Diguanylate cyclase
HRE53_08845	COG2144	transferase activity, transferring acyl groups
HRE53_08900	COG0438	transferase activity, transferring glycosyl groups
HRE53_08930	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_08950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE53_08965	COG1597	lipid kinase activity
HRE53_08965	COG1803	Methylglyoxal synthase
HRE53_08970	COG0625	glutathione transferase activity
HRE53_08990	COG0583	DNA-binding transcription factor activity
HRE53_09005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRE53_09030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRE53_09035	COG1494	fructose-1,6-bisphosphatase
HRE53_09045	COG0583	DNA-binding transcription factor activity
HRE53_09055	COG0456	acetyltransferase
HRE53_09055	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HRE53_09085	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HRE53_09090	COG0156	8-amino-7-oxononanoate synthase activity
HRE53_09125	COG0596	Alpha beta hydrolase
HRE53_09150	COG0728	peptidoglycan biosynthetic process
HRE53_09165	COG2988	succinylglutamate desuccinylase activity
HRE53_09170	COG2988	succinylglutamate desuccinylase activity
HRE53_09180	COG0728	peptidoglycan biosynthetic process
HRE53_09190	COG1716	ATPase activity
HRE53_09190	COG5001	Diguanylate cyclase
HRE53_09195	COG4221	oxidoreductase activity
HRE53_09200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRE53_09210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRE53_09235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE53_09255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRE53_09270	COG0442	prolyl-tRNA aminoacylation
HRE53_09290	COG0387	Pfam Sodium calcium exchanger
HRE53_09310	COG0740	serine-type endopeptidase activity
HRE53_09315	COG0740	serine-type endopeptidase activity
HRE53_09355	COG0564	pseudouridine synthase activity
HRE53_09370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_09375	COG1489	DNA binding
HRE53_09385	COG0602	queuosine metabolic process
HRE53_09390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRE53_09400	COG1040	competence protein
HRE53_09405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRE53_09405	COG0574	Belongs to the PEP-utilizing enzyme family
HRE53_09415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRE53_09430	COG0739	heme binding
HRE53_09440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRE53_09455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRE53_09470	COG0714	Associated with various cellular activities
HRE53_09490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_09495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRE53_09500	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HRE53_09525	COG0631	protein serine/threonine phosphatase activity
HRE53_09570	COG5001	Diguanylate cyclase
HRE53_09570	COG1716	ATPase activity
HRE53_09620	COG2176	DNA-directed DNA polymerase activity
HRE53_09655	COG0583	DNA-binding transcription factor activity
HRE53_09660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRE53_09665	COG0563	adenylate kinase activity
HRE53_09670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRE53_09675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRE53_09685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRE53_09700	COG2154	pterin-4-alpha-carbinolamine dehydratase
HRE53_09705	COG0357	Ribosomal RNA small subunit methyltransferase G
HRE53_09710	COG3128	pkhd-type hydroxylase
HRE53_09720	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_09720	COG2319	Wd-40 repeat
HRE53_09725	COG0415	Belongs to the DNA photolyase family
HRE53_09740	COG3693	PFAM glycoside hydrolase, family 10
HRE53_09760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_09780	COG0443	Heat shock 70 kDa protein
HRE53_09790	COG3328	transposase activity
HRE53_09810	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRE53_09820	COG2885	chlorophyll binding
HRE53_09825	COG2885	chlorophyll binding
HRE53_09840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRE53_09855	COG0312	modulator of DNA gyrase
HRE53_09860	COG0312	modulator of DNA gyrase
HRE53_09865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRE53_09875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRE53_09880	COG0438	transferase activity, transferring glycosyl groups
HRE53_09955	COG3001	Fructosamine kinase
HRE53_09975	COG1619	proteins homologs of microcin C7 resistance protein MccF
HRE53_09990	COG3118	belongs to the thioredoxin family
HRE53_09995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_10000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_10005	COG0714	Associated with various cellular activities
HRE53_10010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRE53_10020	COG2205	protein histidine kinase activity
HRE53_10025	COG2319	Wd-40 repeat
HRE53_10025	COG1672	PFAM Archaeal ATPase
HRE53_10065	COG0587	DNA-directed DNA polymerase activity
HRE53_10070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRE53_10075	COG4245	von Willebrand factor, type A
HRE53_10100	COG0705	Rhomboid family
HRE53_10115	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_10120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRE53_10125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRE53_10150	COG0464	growth
HRE53_10170	COG0724	RNA recognition motif
HRE53_10175	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRE53_10180	COG1047	Peptidyl-prolyl cis-trans
HRE53_10195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRE53_10195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRE53_10200	COG0436	Aminotransferase
HRE53_10225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRE53_10255	COG4447	cellulose binding
HRE53_10260	COG1773	rubredoxin
HRE53_10270	COG0012	GTP binding
HRE53_10275	COG1982	Orn Lys Arg decarboxylase major
HRE53_10290	COG0363	glucosamine-6-phosphate deaminase activity
HRE53_10295	COG1716	ATPase activity
HRE53_10300	COG2815	serine threonine protein kinase
HRE53_10300	COG0515	serine threonine protein kinase
HRE53_10320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRE53_10335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRE53_10335	COG4651	solute:proton antiporter activity
HRE53_10340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRE53_10345	COG1234	tRNA 3'-trailer cleavage
HRE53_10350	COG0196	riboflavin kinase activity
HRE53_10355	COG0714	Associated with various cellular activities
HRE53_10375	COG1104	cysteine desulfurase activity
HRE53_10410	COG1196	nuclear chromosome segregation
HRE53_10410	COG0741	lytic transglycosylase activity
HRE53_10410	COG0739	heme binding
HRE53_10420	COG5001	Diguanylate cyclase
HRE53_10420	COG1716	ATPase activity
HRE53_10425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRE53_10455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRE53_10465	COG1252	NADH dehydrogenase
HRE53_10470	COG0450	alkyl hydroperoxide reductase
HRE53_10475	COG0463	Glycosyl transferase, family 2
HRE53_10490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRE53_10515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE53_10525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE53_10555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_10560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_10585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRE53_10590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRE53_10660	COG1595	DNA-templated transcription, initiation
HRE53_10700	COG3328	transposase activity
HRE53_10720	COG0358	DNA primase activity
HRE53_10725	COG3118	belongs to the thioredoxin family
HRE53_10730	COG1716	ATPase activity
HRE53_10740	COG0140	phosphoribosyl-ATP diphosphatase activity
HRE53_10740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRE53_10755	COG0475	glutathione-regulated potassium exporter activity
HRE53_10755	COG0589	response to stress
HRE53_10765	COG0431	NADPH-dependent FMN reductase
HRE53_10780	COG1695	Transcriptional regulator
HRE53_10800	COG2852	Protein conserved in bacteria
HRE53_10815	COG2197	response regulator
HRE53_10825	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HRE53_10835	COG0393	Putative heavy-metal-binding
HRE53_10865	COG0247	lactate metabolic process
HRE53_10870	COG0277	FAD linked oxidase domain protein
HRE53_10905	COG2010	Cytochrome c
HRE53_10915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRE53_10945	COG0497	DNA recombination
HRE53_10960	COG0237	dephospho-CoA kinase activity
HRE53_10965	COG2217	Heavy metal translocating P-type atpase
HRE53_11010	COG1053	succinate dehydrogenase
HRE53_11015	COG2165	general secretion pathway protein
HRE53_11025	COG1309	transcriptional regulator
HRE53_11030	COG4680	protein conserved in bacteria
HRE53_11040	COG2267	carboxylic ester hydrolase activity
HRE53_11045	COG2723	6-phospho-beta-galactosidase activity
HRE53_11050	COG3266	domain, Protein
HRE53_11050	COG0515	serine threonine protein kinase
HRE53_11075	COG2954	triphosphatase activity
HRE53_11085	COG5002	protein histidine kinase activity
HRE53_11090	COG1981	membrane
HRE53_11095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRE53_11105	COG1196	nuclear chromosome segregation
HRE53_11115	COG2894	cell division
HRE53_11135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRE53_11145	COG3250	beta-galactosidase activity
HRE53_11150	COG3291	Pkd domain containing protein
HRE53_11155	COG1872	DUF167
HRE53_11170	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_11170	COG0515	serine threonine protein kinase
HRE53_11200	COG0457	Tetratricopeptide repeat
HRE53_11225	COG0010	Belongs to the arginase family
HRE53_11230	COG0375	protein maturation
HRE53_11245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRE53_11250	COG1116	anion transmembrane transporter activity
HRE53_11260	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRE53_11265	COG0515	serine threonine protein kinase
HRE53_11265	COG3266	domain, Protein
HRE53_11280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRE53_11305	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HRE53_11330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRE53_11335	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRE53_11345	COG0717	Belongs to the dCTP deaminase family
HRE53_11350	COG3751	2OG-Fe(II) oxygenase superfamily
HRE53_11355	COG2099	Precorrin-6x reductase
HRE53_11360	COG1716	ATPase activity
HRE53_11360	COG5001	Diguanylate cyclase
HRE53_11365	COG0335	large ribosomal subunit rRNA binding
HRE53_11375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRE53_11380	COG0250	Participates in transcription elongation, termination and antitermination
HRE53_11385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRE53_11390	COG0081	regulation of translation
HRE53_11395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRE53_11400	COG0222	ribosome binding
HRE53_11405	COG1799	cell septum assembly
HRE53_11420	COG1131	(ABC) transporter
HRE53_11420	COG1716	ATPase activity
HRE53_11420	COG0842	Transport permease protein
HRE53_11425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRE53_11435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRE53_11440	COG3429	Glucose-6-phosphate dehydrogenase subunit
HRE53_11440	COG3409	Peptidoglycan-binding domain 1 protein
HRE53_11450	COG1797	cobyrinic acid a,c-diamide synthase activity
HRE53_11460	COG0632	four-way junction helicase activity
HRE53_11475	COG0596	Alpha beta hydrolase
HRE53_11540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRE53_11550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRE53_11560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRE53_11580	COG0163	prenyltransferase activity
HRE53_11590	COG0346	lactoylglutathione lyase activity
HRE53_11600	COG0504	CTP synthase activity
HRE53_11605	COG1940	carbohydrate kinase activity
HRE53_11610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRE53_11640	COG1253	flavin adenine dinucleotide binding
HRE53_11650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRE53_11705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRE53_11730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRE53_11740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_11765	COG0601	transmembrane transport
HRE53_11770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRE53_11815	COG4636	protein conserved in cyanobacteria
HRE53_11835	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_11835	COG0515	serine threonine protein kinase
HRE53_11840	COG1175	transmembrane transport
HRE53_11885	COG1131	(ABC) transporter
HRE53_11920	COG0038	chloride channel
HRE53_11930	COG1011	Hydrolase
HRE53_11965	COG2223	nitrite transmembrane transporter activity
HRE53_11970	COG3659	wide pore channel activity
HRE53_11975	COG0243	molybdopterin cofactor binding
HRE53_11980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRE53_11985	COG0778	Nitroreductase
HRE53_12035	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRE53_12045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRE53_12085	COG2166	iron-sulfur cluster assembly
HRE53_12090	COG0523	cobalamin synthesis protein
HRE53_12125	COG3220	belongs to the UPF0276 family
HRE53_12155	COG0523	cobalamin synthesis protein
HRE53_12190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRE53_12210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_12220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRE53_12220	COG4451	ribulose bisphosphate carboxylase, small
HRE53_12235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRE53_12240	COG0302	gtp cyclohydrolase
HRE53_12245	COG0523	cobalamin synthesis protein
HRE53_12280	COG3328	transposase activity
HRE53_12295	COG0523	cobalamin synthesis protein
HRE53_12300	COG0113	porphobilinogen synthase activity
HRE53_12305	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRE53_12305	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRE53_12310	COG1121	(ABC) transporter
HRE53_12315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE53_12325	COG3328	transposase activity
HRE53_12360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRE53_12365	COG1472	Belongs to the glycosyl hydrolase 3 family
HRE53_12385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRE53_12390	COG0321	lipoyl(octanoyl) transferase activity
HRE53_12395	COG0314	molybdopterin synthase activity
HRE53_12410	COG0706	membrane insertase activity
HRE53_12420	COG0594	ribonuclease P activity
HRE53_12425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRE53_12430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRE53_12435	COG0592	DNA-directed DNA polymerase activity
HRE53_12450	COG0463	Glycosyl transferase, family 2
HRE53_12455	COG0745	RESPONSE REGULATOR receiver
HRE53_12460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRE53_12465	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HRE53_12470	COG2211	Major facilitator Superfamily
HRE53_12495	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_12515	COG1012	belongs to the aldehyde dehydrogenase family
HRE53_12525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRE53_12540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRE53_12555	COG4251	negative regulation of phosphorylation
HRE53_12565	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRE53_12575	COG2027	D-alanyl-D-alanine carboxypeptidase
HRE53_12605	COG3328	transposase activity
HRE53_12620	COG0681	Belongs to the peptidase S26 family
HRE53_12630	COG0129	dihydroxy-acid dehydratase activity
HRE53_12655	COG2319	Wd-40 repeat
HRE53_12655	COG3903	Transcriptional regulator
HRE53_12660	COG0824	Thioesterase
HRE53_12695	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRE53_12700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_12710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRE53_12720	COG3842	ATPase activity
HRE53_12725	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_12725	COG0515	serine threonine protein kinase
HRE53_12730	COG0629	single-stranded DNA binding
HRE53_12735	COG0628	permease
HRE53_12740	COG0752	glycyl-tRNA synthetase alpha subunit
HRE53_12770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_12785	COG0316	Belongs to the HesB IscA family
HRE53_12825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRE53_12830	COG2274	protein secretion by the type I secretion system
HRE53_12855	COG0789	Transcriptional regulator
HRE53_12855	COG4978	Transcriptional regulator
HRE53_12870	COG0515	serine threonine protein kinase
HRE53_12870	COG3266	domain, Protein
HRE53_12890	COG2273	Hydrolase Family 16
HRE53_12890	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRE53_12900	COG0438	transferase activity, transferring glycosyl groups
HRE53_12905	COG0659	secondary active sulfate transmembrane transporter activity
HRE53_12910	COG0475	glutathione-regulated potassium exporter activity
HRE53_12915	COG1006	Multisubunit Na H antiporter MnhC subunit
HRE53_12980	COG0459	protein refolding
HRE53_13000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_13015	COG0492	ferredoxin-NADP+ reductase activity
HRE53_13040	COG0745	RESPONSE REGULATOR receiver
HRE53_13050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_13055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_13060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_13070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_13075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRE53_13075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRE53_13080	COG3328	transposase activity
HRE53_13090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRE53_13190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRE53_13235	COG0251	oxidation-reduction process
HRE53_13245	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRE53_13245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRE53_13275	COG0028	Belongs to the TPP enzyme family
HRE53_13290	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRE53_13305	COG0469	pyruvate kinase activity
HRE53_13310	COG1959	2 iron, 2 sulfur cluster binding
HRE53_13355	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRE53_13360	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRE53_13370	COG5002	protein histidine kinase activity
HRE53_13370	COG5001	Diguanylate cyclase
HRE53_13375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE53_13385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRE53_13390	COG0649	NAD binding
HRE53_13410	COG1063	alcohol dehydrogenase
HRE53_13430	COG1063	alcohol dehydrogenase
HRE53_13435	COG1063	alcohol dehydrogenase
HRE53_13440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRE53_13460	COG0346	lactoylglutathione lyase activity
HRE53_13485	COG0625	glutathione transferase activity
HRE53_13490	COG1902	pentaerythritol trinitrate reductase activity
HRE53_13505	COG4221	oxidoreductase activity
HRE53_13510	COG1064	alcohol dehydrogenase
HRE53_13520	COG0515	serine threonine protein kinase
HRE53_13520	COG3266	domain, Protein
HRE53_13525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_13540	COG2211	Major facilitator Superfamily
HRE53_13545	COG1722	exodeoxyribonuclease VII activity
HRE53_13550	COG1570	exodeoxyribonuclease VII activity
HRE53_13555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRE53_13560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRE53_13605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_13625	COG1120	ATPase activity
HRE53_13630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRE53_13645	COG0492	ferredoxin-NADP+ reductase activity
HRE53_13660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_13705	COG3588	fructose-bisphosphate aldolase
HRE53_13720	COG3128	pkhd-type hydroxylase
HRE53_13750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_13765	COG3335	DDE superfamily endonuclease
HRE53_13770	COG2207	Transcriptional regulator
HRE53_13775	COG4771	TonB-dependent receptor
HRE53_13805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_13840	COG0783	Belongs to the Dps family
HRE53_13845	COG0848	biopolymer transport protein
HRE53_13850	COG0811	peptide transport
HRE53_13865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRE53_13870	COG1120	ATPase activity
HRE53_13875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_13890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_13925	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRE53_13930	COG0052	Belongs to the universal ribosomal protein uS2 family
HRE53_13935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRE53_13955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRE53_13965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRE53_13995	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRE53_14000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRE53_14005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRE53_14010	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRE53_14015	COG0740	serine-type endopeptidase activity
HRE53_14020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRE53_14025	COG2267	carboxylic ester hydrolase activity
HRE53_14040	COG5001	Diguanylate cyclase
HRE53_14040	COG5002	protein histidine kinase activity
HRE53_14055	COG0456	acetyltransferase
HRE53_14080	COG0288	reversible hydration of carbon dioxide
HRE53_14090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRE53_14125	COG5002	protein histidine kinase activity
HRE53_14130	COG0745	RESPONSE REGULATOR receiver
HRE53_14160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRE53_14170	COG0573	inorganic phosphate transmembrane transporter activity
HRE53_14180	COG0640	Transcriptional regulator
HRE53_14210	COG3328	transposase activity
HRE53_14215	COG1733	regulation of RNA biosynthetic process
HRE53_14220	COG1902	pentaerythritol trinitrate reductase activity
HRE53_14255	COG1748	Saccharopine dehydrogenase
HRE53_14260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRE53_14270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRE53_14285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRE53_14290	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_14290	COG0204	Acyl-transferase
HRE53_14300	COG0242	peptide deformylase activity
HRE53_14330	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRE53_14335	COG0010	Belongs to the arginase family
HRE53_14345	COG0154	amidase activity
HRE53_14355	COG0004	ammonium transporteR
HRE53_14440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_14445	COG3540	Alkaline phosphatase
HRE53_14465	COG4221	oxidoreductase activity
HRE53_14500	COG2124	cytochrome p450
HRE53_14505	COG0753	catalase activity
HRE53_14510	COG0515	serine threonine protein kinase
HRE53_14510	COG2815	serine threonine protein kinase
HRE53_14515	COG2204	response regulator
HRE53_14520	COG4191	Histidine kinase
HRE53_14520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_14535	COG0116	Belongs to the methyltransferase superfamily
HRE53_14550	COG0822	iron-sulfur transferase activity
HRE53_14560	COG0371	Dehydrogenase
HRE53_14565	COG0436	Aminotransferase
HRE53_14570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRE53_14575	COG0569	domain protein
HRE53_14580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRE53_14590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRE53_14595	COG0406	alpha-ribazole phosphatase activity
HRE53_14625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRE53_14630	COG0268	Binds directly to 16S ribosomal RNA
HRE53_14635	COG0084	hydrolase, TatD family'
HRE53_14640	COG0085	RNA polymerase activity
HRE53_14645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRE53_14650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRE53_14660	COG0534	Mate efflux family protein
HRE53_14675	COG2022	thiamine diphosphate biosynthetic process
HRE53_14680	COG1595	DNA-templated transcription, initiation
HRE53_14690	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRE53_14735	COG0438	transferase activity, transferring glycosyl groups
HRE53_14745	COG2226	methyltransferase
HRE53_14775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE53_14820	COG0673	inositol 2-dehydrogenase activity
HRE53_14850	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRE53_14855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRE53_14860	COG0799	negative regulation of ribosome biogenesis
HRE53_14895	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRE53_14910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE53_14915	COG1215	transferase activity, transferring glycosyl groups
HRE53_14925	COG3769	mannosylglycerate metabolic process
HRE53_14935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRE53_14955	COG2045	Belongs to the ComB family
HRE53_14960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRE53_14990	COG2082	Precorrin-8x methylmutase
HRE53_15005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRE53_15015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRE53_15030	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_15040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_15050	COG0300	oxidoreductase activity
HRE53_15065	COG0735	belongs to the Fur family
HRE53_15075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE53_15085	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HRE53_15115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRE53_15115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRE53_15130	COG0343	queuine tRNA-ribosyltransferase activity
HRE53_15140	COG0701	Predicted permease
HRE53_15150	COG2205	protein histidine kinase activity
HRE53_15150	COG2198	Histidine kinase
HRE53_15150	COG0784	Response regulator, receiver
HRE53_15160	COG2197	response regulator
HRE53_15175	COG3263	regulation of cellular component size
HRE53_15205	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRE53_15215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE53_15240	COG3903	Transcriptional regulator
HRE53_15240	COG2319	Wd-40 repeat
HRE53_15255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRE53_15275	COG3128	pkhd-type hydroxylase
HRE53_15295	COG2203	Gaf domain
HRE53_15295	COG3706	GGDEF domain
HRE53_15295	COG4251	negative regulation of phosphorylation
HRE53_15295	COG5001	Diguanylate cyclase
HRE53_15315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HRE53_15320	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_15340	COG0667	Aldo Keto reductase
HRE53_15360	COG0589	response to stress
HRE53_15370	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRE53_15390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRE53_15395	COG1716	ATPase activity
HRE53_15395	COG0842	Transport permease protein
HRE53_15395	COG1131	(ABC) transporter
HRE53_15400	COG0515	serine threonine protein kinase
HRE53_15400	COG3266	domain, Protein
HRE53_15410	COG0745	RESPONSE REGULATOR receiver
HRE53_15425	COG0861	Integral membrane protein TerC family
HRE53_15450	COG0105	UTP biosynthetic process
HRE53_15455	COG0671	phosphoesterase, PA-phosphatase related
HRE53_15465	COG3328	transposase activity
HRE53_15485	COG2198	Histidine kinase
HRE53_15485	COG0784	Response regulator, receiver
HRE53_15485	COG0643	Histidine kinase
HRE53_15490	COG2203	Gaf domain
HRE53_15490	COG0840	transmembrane signaling receptor activity
HRE53_15505	COG0784	Response regulator, receiver
HRE53_15515	COG5002	protein histidine kinase activity
HRE53_15515	COG0784	Response regulator, receiver
HRE53_15515	COG2205	protein histidine kinase activity
HRE53_15520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRE53_15530	COG1876	peptidase activity
HRE53_15535	COG0515	serine threonine protein kinase
HRE53_15535	COG3266	domain, Protein
HRE53_15540	COG4948	Mandelate Racemase Muconate Lactonizing
HRE53_15545	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_15575	COG3239	Fatty acid desaturase
HRE53_15660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRE53_15700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRE53_15705	COG0552	protein localization to endoplasmic reticulum
HRE53_15710	COG2208	phosphoserine phosphatase activity
HRE53_15720	COG0006	proline dipeptidase activity
HRE53_15765	COG0308	aminopeptidase N
HRE53_15790	COG0432	Pfam Uncharacterised protein family UPF0047
HRE53_15820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE53_15835	COG1940	carbohydrate kinase activity
HRE53_15865	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRE53_15875	COG2161	toxin-antitoxin pair type II binding
HRE53_15880	COG2226	methyltransferase
HRE53_15895	COG1201	RNA secondary structure unwinding
HRE53_15900	COG4251	negative regulation of phosphorylation
HRE53_15905	COG4251	negative regulation of phosphorylation
HRE53_15910	COG0745	RESPONSE REGULATOR receiver
HRE53_15920	COG0484	heat shock protein binding
HRE53_15930	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_15935	COG2081	HI0933 family
HRE53_15940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRE53_15950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRE53_15960	COG2010	Cytochrome c
HRE53_15965	COG2010	Cytochrome c
HRE53_15970	COG2010	Cytochrome c
HRE53_15985	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_15995	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HRE53_16005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRE53_16065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRE53_16075	COG4115	mRNA cleavage
HRE53_16110	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_16110	COG0515	serine threonine protein kinase
HRE53_16125	COG0745	RESPONSE REGULATOR receiver
HRE53_16130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRE53_16135	COG1194	a g-specific adenine glycosylase
HRE53_16150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_16155	COG2091	lysine biosynthetic process via aminoadipic acid
HRE53_16160	COG0426	domain, Protein
HRE53_16160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRE53_16185	COG0511	ligase activity, forming carbon-carbon bonds
HRE53_16190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRE53_16205	COG3932	Exopolysaccharide synthesis, ExoD
HRE53_16210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRE53_16230	COG0181	hydroxymethylbilane synthase activity
HRE53_16240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE53_16245	COG0205	6-phosphofructokinase activity
HRE53_16250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRE53_16260	COG2319	Wd-40 repeat
HRE53_16260	COG3903	Transcriptional regulator
HRE53_16265	COG0515	serine threonine protein kinase
HRE53_16275	COG0792	nuclease activity
HRE53_16285	COG0747	negative chemotaxis
HRE53_16290	COG0633	Ferredoxin
HRE53_16325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRE53_16335	COG1555	photosystem II stabilization
HRE53_16345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_16390	COG0148	phosphopyruvate hydratase activity
HRE53_16395	COG0346	lactoylglutathione lyase activity
HRE53_16400	COG3659	wide pore channel activity
HRE53_16405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRE53_16410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRE53_16415	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRE53_16430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRE53_16435	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_16440	COG0484	heat shock protein binding
HRE53_16445	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HRE53_16450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRE53_16475	COG0436	Aminotransferase
HRE53_16480	COG1842	Phage shock protein A
HRE53_16490	COG0667	Aldo Keto reductase
HRE53_16495	COG0372	Belongs to the citrate synthase family
HRE53_16645	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HRE53_16650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_16660	COG0515	serine threonine protein kinase
HRE53_16680	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HRE53_16685	COG5322	oxidoreductase activity
HRE53_16720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRE53_16730	COG0745	RESPONSE REGULATOR receiver
HRE53_16735	COG4581	dead DEAH box helicase
HRE53_16740	COG0643	Histidine kinase
HRE53_16740	COG2198	Histidine kinase
HRE53_16745	COG0840	transmembrane signaling receptor activity
HRE53_16765	COG1573	uracil-dna glycosylase
HRE53_16780	COG0750	zinc metalloprotease
HRE53_16785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRE53_16790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRE53_16805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRE53_16810	COG0215	cysteine-tRNA ligase activity
HRE53_16820	COG5001	Diguanylate cyclase
HRE53_16820	COG1716	ATPase activity
HRE53_16830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_16860	COG2855	membrane
HRE53_16880	COG3265	gluconokinase activity
HRE53_16885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE53_16890	COG1121	(ABC) transporter
HRE53_16895	COG0228	four-way junction DNA binding
HRE53_16905	COG1702	phosphate starvation-inducible protein PhoH
HRE53_16920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRE53_16930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRE53_16950	COG0702	epimerase
HRE53_16965	COG2183	response to ionizing radiation
HRE53_16980	COG3328	transposase activity
HRE53_17005	COG3328	transposase activity
HRE53_17025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRE53_17030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRE53_17085	COG0456	acetyltransferase
HRE53_17090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRE53_17115	COG0697	spore germination
HRE53_17130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRE53_17145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRE53_17150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_17150	COG5549	protein import
HRE53_17180	COG0583	DNA-binding transcription factor activity
HRE53_17200	COG2319	Wd-40 repeat
HRE53_17200	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_17225	COG0347	Belongs to the P(II) protein family
HRE53_17240	COG0697	spore germination
HRE53_17290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRE53_17315	COG1672	PFAM Archaeal ATPase
HRE53_17315	COG2319	Wd-40 repeat
HRE53_17345	COG2255	four-way junction helicase activity
HRE53_17350	COG1690	Belongs to the RtcB family
HRE53_17375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRE53_17380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRE53_17390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_17430	COG1104	cysteine desulfurase activity
HRE53_17470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRE53_17485	COG1214	PFAM Peptidase M22, glycoprotease
HRE53_17490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRE53_17500	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRE53_17505	COG0519	Catalyzes the synthesis of GMP from XMP
HRE53_17505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRE53_17515	COG2202	Pas domain
HRE53_17515	COG2205	protein histidine kinase activity
HRE53_17545	COG0534	Mate efflux family protein
HRE53_17555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRE53_17570	COG1132	(ABC) transporter
HRE53_17580	COG3258	Cytochrome c
HRE53_17595	COG0805	protein transport
HRE53_17600	COG2259	Doxx family
HRE53_17630	COG0793	Belongs to the peptidase S41A family
HRE53_17640	COG1380	Effector of murein hydrolase LrgA
HRE53_17645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRE53_17720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRE53_17750	COG0745	RESPONSE REGULATOR receiver
HRE53_17755	COG1672	PFAM Archaeal ATPase
HRE53_17755	COG2319	Wd-40 repeat
HRE53_17760	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_17790	COG0519	Catalyzes the synthesis of GMP from XMP
HRE53_17805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRE53_17820	COG0170	dolichyl monophosphate biosynthetic process
HRE53_17835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRE53_17875	COG0788	formyltetrahydrofolate deformylase activity
HRE53_17905	COG1070	Carbohydrate kinase
HRE53_17940	COG0395	ABC-type sugar transport system, permease component
HRE53_17950	COG0165	Argininosuccinate lyase
HRE53_17960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRE53_17965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRE53_17970	COG0459	protein refolding
HRE53_18005	COG1333	cytochrome c biogenesis protein
HRE53_18005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRE53_18050	COG0741	lytic transglycosylase activity
HRE53_18050	COG1196	nuclear chromosome segregation
HRE53_18050	COG0739	heme binding
HRE53_18055	COG1132	(ABC) transporter
HRE53_18065	COG0149	triose-phosphate isomerase activity
HRE53_18070	COG0583	DNA-binding transcription factor activity
HRE53_18075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRE53_18080	COG0746	molybdenum cofactor guanylyltransferase activity
HRE53_18100	COG0531	amino acid
HRE53_18115	COG0210	DNA helicase
HRE53_18125	COG1304	FMN binding
HRE53_18145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRE53_18150	COG2003	Belongs to the UPF0758 family
HRE53_18155	COG0284	orotidine-5'-phosphate decarboxylase activity
HRE53_18160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRE53_18170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_18180	COG0517	IMP dehydrogenase activity
HRE53_18180	COG1994	Peptidase M50
HRE53_18185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE53_18190	COG0134	indole-3-glycerol-phosphate synthase activity
HRE53_18210	COG1187	pseudouridine synthase activity
HRE53_18220	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
HRE53_18225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_18230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRE53_18235	COG1691	(AIR) carboxylase
HRE53_18245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRE53_18250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRE53_18255	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_18260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRE53_18305	COG0686	Belongs to the AlaDH PNT family
HRE53_18315	COG2890	protein-(glutamine-N5) methyltransferase activity
HRE53_18340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRE53_18355	COG0515	serine threonine protein kinase
HRE53_18365	COG0515	serine threonine protein kinase
HRE53_18365	COG3064	Membrane
HRE53_18365	COG4991	sh3 domain protein
HRE53_18370	COG0515	serine threonine protein kinase
HRE53_18375	COG0072	phenylalanine-tRNA ligase activity
HRE53_18375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE53_18380	COG2203	Gaf domain
HRE53_18380	COG5001	Diguanylate cyclase
HRE53_18380	COG4251	negative regulation of phosphorylation
HRE53_18380	COG3706	GGDEF domain
HRE53_18450	COG1704	LemA family
HRE53_18460	COG4251	negative regulation of phosphorylation
HRE53_18465	COG0784	Response regulator, receiver
HRE53_18470	COG5001	Diguanylate cyclase
HRE53_18470	COG3447	MASE1 domain protein
HRE53_18470	COG5002	protein histidine kinase activity
HRE53_18485	COG2340	Cysteine-rich secretory protein family
HRE53_18490	COG2304	oxidoreductase activity
HRE53_18495	COG0640	Transcriptional regulator
HRE53_18500	COG2912	Transglutaminase-like superfamily
HRE53_18505	COG5002	protein histidine kinase activity
HRE53_18515	COG0557	exoribonuclease II activity
HRE53_18590	COG0137	argininosuccinate synthase activity
HRE53_18610	COG1077	Cell shape determining protein MreB Mrl
HRE53_18615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRE53_18625	COG1492	cobalamin metabolic process
HRE53_18635	COG3956	TIGRFAM MazG family protein
HRE53_18685	COG2205	protein histidine kinase activity
HRE53_18690	COG3022	response to hydroperoxide
HRE53_18695	COG2226	methyltransferase
HRE53_18720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_18745	COG1132	(ABC) transporter
HRE53_18750	COG0745	RESPONSE REGULATOR receiver
HRE53_18785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRE53_18785	COG2022	thiamine diphosphate biosynthetic process
HRE53_18790	COG0009	L-threonylcarbamoyladenylate synthase
HRE53_18800	COG3655	Transcriptional regulator
HRE53_18805	COG0270	DNA (cytosine-5-)-methyltransferase activity
HRE53_18855	COG2897	thiosulfate sulfurtransferase activity
HRE53_18860	COG4566	intracellular signal transduction
HRE53_18920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRE53_18925	COG0563	adenylate kinase activity
HRE53_18930	COG0201	protein transport
HRE53_18935	COG0200	Binds to the 23S rRNA
HRE53_18940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRE53_18945	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRE53_18950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRE53_18955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRE53_18960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRE53_18965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRE53_18970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRE53_18975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRE53_18980	COG0255	Belongs to the universal ribosomal protein uL29 family
HRE53_18985	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRE53_18990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRE53_18995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRE53_19000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRE53_19005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRE53_19010	COG0089	rRNA binding
HRE53_19015	COG0088	Forms part of the polypeptide exit tunnel
HRE53_19020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRE53_19085	COG2226	methyltransferase
HRE53_19095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRE53_19120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRE53_19125	COG0328	RNA-DNA hybrid ribonuclease activity
HRE53_19135	COG1078	dGTPase activity
HRE53_19140	COG0793	Belongs to the peptidase S41A family
HRE53_19145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRE53_19150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRE53_19155	COG0242	peptide deformylase activity
HRE53_19160	COG0758	DNA mediated transformation
HRE53_19160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRE53_19165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRE53_19170	COG3239	Fatty acid desaturase
HRE53_19175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRE53_19190	COG1595	DNA-templated transcription, initiation
HRE53_19200	COG1587	Uroporphyrinogen-III synthase
HRE53_19225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRE53_19235	COG0850	regulation of cytokinetic process
HRE53_19240	COG2894	cell division
HRE53_19245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRE53_19250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRE53_19255	COG1543	Belongs to the glycosyl hydrolase 57 family
HRE53_19280	COG0438	transferase activity, transferring glycosyl groups
HRE53_19280	COG0297	glycogen (starch) synthase activity
HRE53_19290	COG1381	Involved in DNA repair and RecF pathway recombination
HRE53_19295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRE53_19305	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRE53_19340	COG0109	protoheme IX farnesyltransferase activity
HRE53_19345	COG1612	heme a metabolic process
HRE53_19350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRE53_19355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRE53_19360	COG1845	cytochrome c oxidase, subunit III
HRE53_19365	COG0157	Belongs to the NadC ModD family
HRE53_19370	COG0583	DNA-binding transcription factor activity
HRE53_19395	COG2319	Wd-40 repeat
HRE53_19395	COG1672	PFAM Archaeal ATPase
HRE53_19415	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HRE53_19425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_19450	COG4989	oxidoreductase activity
HRE53_19465	COG0259	pyridoxamine-phosphate oxidase activity
HRE53_19485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_19495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_19515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_19520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_19530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_19540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRE53_19550	COG0857	belongs to the CobB CobQ family
HRE53_19560	COG0535	radical SAM domain protein
HRE53_19565	COG1215	transferase activity, transferring glycosyl groups
HRE53_19570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRE53_19580	COG1490	D-aminoacyl-tRNA deacylase activity
HRE53_19585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRE53_19590	COG0539	negative regulation of cytoplasmic translation
HRE53_19600	COG5001	Diguanylate cyclase
HRE53_19600	COG4251	negative regulation of phosphorylation
HRE53_19600	COG3706	GGDEF domain
HRE53_19600	COG2203	Gaf domain
HRE53_19605	COG0714	Associated with various cellular activities
HRE53_19610	COG0714	Associated with various cellular activities
HRE53_19635	COG2052	Domain of unknown function (DUF370)
HRE53_19640	COG0194	GDP metabolic process
HRE53_19650	COG0450	alkyl hydroperoxide reductase
HRE53_19660	COG0347	Belongs to the P(II) protein family
HRE53_19680	COG0557	exoribonuclease II activity
HRE53_19685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRE53_19690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRE53_19730	COG1324	tolerance protein
HRE53_19745	COG1562	ergosterol biosynthetic process
HRE53_19755	COG2226	methyltransferase
HRE53_19795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRE53_19805	COG0640	Transcriptional regulator
HRE53_19810	COG3118	belongs to the thioredoxin family
HRE53_19815	COG1902	pentaerythritol trinitrate reductase activity
HRE53_19830	COG1879	ABC-type sugar transport system periplasmic component
HRE53_19835	COG1657	PFAM Prenyltransferase squalene oxidase
HRE53_19860	COG0793	Belongs to the peptidase S41A family
HRE53_19875	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HRE53_19885	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_19910	COG0612	Peptidase, M16
HRE53_19915	COG0612	Peptidase, M16
HRE53_19925	COG0489	protein tyrosine kinase activity
HRE53_19950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRE53_19960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRE53_19990	COG0133	tryptophan synthase activity
HRE53_20000	COG0113	porphobilinogen synthase activity
HRE53_20115	COG5001	Diguanylate cyclase
HRE53_20115	COG1716	ATPase activity
HRE53_20120	COG0018	arginyl-trna synthetase
HRE53_20135	COG2226	methyltransferase
HRE53_20140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRE53_20145	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_20145	COG0515	serine threonine protein kinase
HRE53_20160	COG1316	TRANSCRIPTIONal
HRE53_20170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_20175	COG1063	alcohol dehydrogenase
HRE53_20185	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HRE53_20190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRE53_20195	COG0539	negative regulation of cytoplasmic translation
HRE53_20200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRE53_20225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRE53_20230	COG2046	Belongs to the sulfate adenylyltransferase family
HRE53_20250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRE53_20265	COG0745	RESPONSE REGULATOR receiver
HRE53_20270	COG5002	protein histidine kinase activity
HRE53_20290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRE53_20295	COG0481	GTPase activity
HRE53_20305	COG0501	Belongs to the peptidase M48B family
HRE53_20340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRE53_20435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRE53_20445	COG0756	dUTP diphosphatase activity
HRE53_20450	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_20455	COG3657	addiction module killer protein
HRE53_20530	COG0515	serine threonine protein kinase
HRE53_20530	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_20550	COG3937	granule-associated protein
HRE53_20560	COG0783	Belongs to the Dps family
HRE53_20570	COG0673	inositol 2-dehydrogenase activity
HRE53_20580	COG1366	Belongs to the anti-sigma-factor antagonist family
HRE53_20590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRE53_20605	COG0505	Belongs to the CarA family
HRE53_20610	COG1716	ATPase activity
HRE53_20620	COG1175	transmembrane transport
HRE53_20625	COG1077	Cell shape determining protein MreB Mrl
HRE53_20640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRE53_20645	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRE53_20650	COG1408	metallophosphoesterase
HRE53_20660	COG0515	serine threonine protein kinase
HRE53_20660	COG3266	domain, Protein
HRE53_20695	COG5002	protein histidine kinase activity
HRE53_20700	COG0745	RESPONSE REGULATOR receiver
HRE53_20710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRE53_20715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRE53_20715	COG1116	anion transmembrane transporter activity
HRE53_20720	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HRE53_20725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRE53_20770	COG2124	cytochrome p450
HRE53_20775	COG3300	MHYT domain
HRE53_20775	COG5001	Diguanylate cyclase
HRE53_20790	COG0514	ATP-dependent DNA helicase (RecQ)
HRE53_20795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_20815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRE53_20840	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRE53_20845	COG0009	L-threonylcarbamoyladenylate synthase
HRE53_20850	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HRE53_20855	COG2205	protein histidine kinase activity
HRE53_20855	COG2198	Histidine kinase
HRE53_20855	COG0784	Response regulator, receiver
HRE53_20880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRE53_20925	COG2319	Wd-40 repeat
HRE53_20925	COG3903	Transcriptional regulator
HRE53_20945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_20950	COG0515	serine threonine protein kinase
HRE53_20950	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_20965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_20970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_20985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRE53_21080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRE53_21090	COG2197	response regulator
HRE53_21155	COG0586	Pfam SNARE associated Golgi protein
HRE53_21170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HRE53_21185	COG3654	unkown
HRE53_21210	COG0589	response to stress
HRE53_21215	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRE53_21225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_21235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRE53_21240	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRE53_21245	COG0572	uridine kinase
HRE53_21255	COG0492	ferredoxin-NADP+ reductase activity
HRE53_21260	COG0142	geranyltranstransferase activity
HRE53_21265	COG0681	Belongs to the peptidase S26 family
HRE53_21270	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HRE53_21275	COG1672	PFAM Archaeal ATPase
HRE53_21280	COG0824	Thioesterase
HRE53_21290	COG0811	peptide transport
HRE53_21295	COG0848	biopolymer transport protein
HRE53_21310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRE53_21310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRE53_21320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRE53_21335	COG0271	Belongs to the BolA IbaG family
HRE53_21340	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRE53_21345	COG3063	Type IV pilus biogenesis stability protein PilW
HRE53_21355	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRE53_21360	COG0352	thiamine-phosphate diphosphorylase activity
HRE53_21385	COG3063	Type IV pilus biogenesis stability protein PilW
HRE53_21415	COG0793	Belongs to the peptidase S41A family
HRE53_21425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HRE53_21455	COG2203	Gaf domain
HRE53_21455	COG5001	Diguanylate cyclase
HRE53_21455	COG3706	GGDEF domain
HRE53_21455	COG4251	negative regulation of phosphorylation
HRE53_21465	COG5002	protein histidine kinase activity
HRE53_21465	COG5001	Diguanylate cyclase
HRE53_21470	COG2234	aminopeptidase activity
HRE53_21555	COG0515	serine threonine protein kinase
HRE53_21555	COG3266	domain, Protein
HRE53_21560	COG0631	protein serine/threonine phosphatase activity
HRE53_21605	COG5002	protein histidine kinase activity
HRE53_21640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_21655	COG1413	lyase activity
HRE53_21690	COG0039	L-malate dehydrogenase activity
HRE53_21695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRE53_21715	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_21735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_21745	COG1555	photosystem II stabilization
HRE53_21750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_21755	COG0517	IMP dehydrogenase activity
HRE53_21755	COG1994	Peptidase M50
HRE53_21810	COG1959	2 iron, 2 sulfur cluster binding
HRE53_21810	COG1295	ribonuclease BN
HRE53_21820	COG3237	CsbD-like
HRE53_21830	COG3437	response regulator, receiver
HRE53_21850	COG5487	UPF0391 membrane protein
HRE53_21855	COG3237	CsbD-like
HRE53_21865	COG0783	Belongs to the Dps family
HRE53_21905	COG0259	pyridoxamine-phosphate oxidase activity
HRE53_21910	COG0534	Mate efflux family protein
HRE53_21925	COG0517	IMP dehydrogenase activity
HRE53_21925	COG1994	Peptidase M50
HRE53_21935	COG0589	response to stress
HRE53_21970	COG4251	negative regulation of phosphorylation
HRE53_21995	COG0784	Response regulator, receiver
HRE53_22000	COG2205	protein histidine kinase activity
HRE53_22000	COG3437	response regulator, receiver
HRE53_22000	COG4999	Histidine kinase
HRE53_22000	COG3850	Histidine kinase
HRE53_22005	COG0784	Response regulator, receiver
HRE53_22005	COG2205	protein histidine kinase activity
HRE53_22015	COG0668	transmembrane transport
HRE53_22040	COG1090	epimerase
HRE53_22050	COG2226	methyltransferase
HRE53_22065	COG0398	Pfam SNARE associated Golgi protein
HRE53_22080	COG0702	epimerase
HRE53_22120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRE53_22125	COG4191	Histidine kinase
HRE53_22125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_22140	COG1361	Conserved repeat domain
HRE53_22145	COG0745	RESPONSE REGULATOR receiver
HRE53_22155	COG1620	l-lactate permease
HRE53_22175	COG0676	glucose-6-phosphate 1-epimerase activity
HRE53_22185	COG0829	nickel cation binding
HRE53_22190	COG0831	urea catabolic process
HRE53_22200	COG0431	NADPH-dependent FMN reductase
HRE53_22205	COG0832	Belongs to the urease beta subunit family
HRE53_22210	COG2815	serine threonine protein kinase
HRE53_22210	COG0515	serine threonine protein kinase
HRE53_22220	COG5002	protein histidine kinase activity
HRE53_22220	COG5001	Diguanylate cyclase
HRE53_22220	COG3447	MASE1 domain protein
HRE53_22225	COG5002	protein histidine kinase activity
HRE53_22225	COG0784	Response regulator, receiver
HRE53_22225	COG2205	protein histidine kinase activity
HRE53_22240	COG0804	urea catabolic process
HRE53_22255	COG0393	Putative heavy-metal-binding
HRE53_22280	COG1132	(ABC) transporter
HRE53_22285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRE53_22290	COG0033	Phosphoglucomutase
HRE53_22295	COG2808	Putative FMN-binding domain
HRE53_22305	COG0617	tRNA 3'-terminal CCA addition
HRE53_22315	COG5433	transposase activity
HRE53_22335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRE53_22375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_22390	COG3118	belongs to the thioredoxin family
HRE53_22405	COG0516	GMP reductase activity
HRE53_22405	COG0517	IMP dehydrogenase activity
HRE53_22420	COG1480	7TM receptor with intracellular HD hydrolase
HRE53_22425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_22450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRE53_22505	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRE53_22555	COG2226	methyltransferase
HRE53_22565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRE53_22575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRE53_22580	COG1606	tRNA processing
HRE53_22600	COG3550	peptidyl-serine autophosphorylation
HRE53_22605	COG3550	peptidyl-serine autophosphorylation
HRE53_22620	COG0438	transferase activity, transferring glycosyl groups
HRE53_22630	COG0297	glycogen (starch) synthase activity
HRE53_22650	COG3206	protein involved in exopolysaccharide biosynthesis
HRE53_22650	COG0489	protein tyrosine kinase activity
HRE53_22660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_22725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE53_22735	COG2259	Doxx family
HRE53_22740	COG0305	Participates in initiation and elongation during chromosome replication
HRE53_22740	COG1372	Participates in initiation and elongation during chromosome replication
HRE53_22740	COG0305	Participates in initiation and elongation during chromosome replication
HRE53_22740	COG1372	Participates in initiation and elongation during chromosome replication
HRE53_22745	COG0359	binds to the 23S rRNA
HRE53_22805	COG1216	Glycosyl transferase, family 2
HRE53_22880	COG3266	domain, Protein
HRE53_22880	COG0515	serine threonine protein kinase
HRE53_22890	COG1187	pseudouridine synthase activity
HRE53_22895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRE53_22910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRE53_22915	COG1799	cell septum assembly
HRE53_22920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRE53_22940	COG0596	Alpha beta hydrolase
HRE53_22945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRE53_22950	COG0739	heme binding
HRE53_22970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_22975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_22980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_22985	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_22990	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HRE53_22995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRE53_22995	COG4451	ribulose bisphosphate carboxylase, small
HRE53_23000	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRE53_23005	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_23010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRE53_23030	COG1597	lipid kinase activity
HRE53_23030	COG1803	Methylglyoxal synthase
HRE53_23060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRE53_23075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRE53_23105	COG0583	DNA-binding transcription factor activity
HRE53_23120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE53_23130	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRE53_23135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRE53_23165	COG0438	transferase activity, transferring glycosyl groups
HRE53_23170	COG2319	Wd-40 repeat
HRE53_23170	COG3903	Transcriptional regulator
HRE53_23175	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_23175	COG0515	serine threonine protein kinase
HRE53_23195	COG3300	MHYT domain
HRE53_23195	COG5001	Diguanylate cyclase
HRE53_23200	COG3920	Histidine kinase
HRE53_23215	COG0438	transferase activity, transferring glycosyl groups
HRE53_23235	COG5001	Diguanylate cyclase
HRE53_23255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRE53_23260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HRE53_23270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRE53_23280	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_23290	COG0471	metal ion transport
HRE53_23290	COG3273	potassium ion transport
HRE53_23295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRE53_23300	COG0798	PFAM Bile acid sodium symporter
HRE53_23305	COG0789	Transcriptional regulator
HRE53_23310	COG0751	glycine-tRNA ligase activity
HRE53_23315	COG0612	Peptidase, M16
HRE53_23325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRE53_23330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRE53_23335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_23340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRE53_23350	COG2124	cytochrome p450
HRE53_23355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRE53_23355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRE53_23360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRE53_23385	COG0408	coproporphyrinogen oxidase activity
HRE53_23390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRE53_23400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRE53_23405	COG0501	Belongs to the peptidase M48B family
HRE53_23425	COG0739	heme binding
HRE53_23430	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRE53_23430	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRE53_23435	COG1496	oxidoreductase activity
HRE53_23465	COG1741	Belongs to the pirin family
HRE53_23475	COG0784	Response regulator, receiver
HRE53_23475	COG2205	protein histidine kinase activity
HRE53_23480	COG0589	response to stress
HRE53_23485	COG0126	phosphoglycerate kinase activity
HRE53_23500	COG0124	histidyl-tRNA synthetase
HRE53_23520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_23525	COG1136	(ABC) transporter
HRE53_23525	COG0577	efflux transmembrane transporter activity
HRE53_23530	COG1136	(ABC) transporter
HRE53_23550	COG5001	Diguanylate cyclase
HRE53_23555	COG0517	IMP dehydrogenase activity
HRE53_23555	COG1994	Peptidase M50
HRE53_23560	COG0095	Lipoate-protein ligase
HRE53_23575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE53_23580	COG0189	ligase activity
HRE53_23585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE53_23620	COG4279	zinc finger
HRE53_23625	COG3328	transposase activity
HRE53_23655	COG0514	ATP-dependent DNA helicase (RecQ)
HRE53_23670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_23685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRE53_23695	COG5002	protein histidine kinase activity
HRE53_23695	COG5001	Diguanylate cyclase
HRE53_23700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_23720	COG0628	permease
HRE53_23730	COG0003	Pfam Anion-transporting ATPase
HRE53_23735	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_23740	COG0825	malonyl-CoA metabolic process
HRE53_23745	COG0300	oxidoreductase activity
HRE53_23750	COG0302	gtp cyclohydrolase
HRE53_23785	COG0418	dihydroorotase activity
HRE53_23795	COG2994	toxin metabolic process
HRE53_23865	COG2201	protein-glutamate methylesterase activity
HRE53_23870	COG5002	protein histidine kinase activity
HRE53_23870	COG2198	Histidine kinase
HRE53_23870	COG0784	Response regulator, receiver
HRE53_23905	COG2204	response regulator
HRE53_23945	COG0784	Response regulator, receiver
HRE53_23945	COG2205	protein histidine kinase activity
HRE53_23945	COG5002	protein histidine kinase activity
HRE53_23950	COG0121	glutamine amidotransferase
HRE53_23960	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HRE53_23965	COG0443	Heat shock 70 kDa protein
HRE53_23970	COG0484	heat shock protein binding
HRE53_23975	COG1704	LemA family
HRE53_23995	COG3046	protein related to deoxyribodipyrimidine photolyase
HRE53_24015	COG0515	serine threonine protein kinase
HRE53_24015	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_24025	COG0515	serine threonine protein kinase
HRE53_24035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRE53_24040	COG0546	phosphoglycolate phosphatase activity
HRE53_24045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRE53_24105	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_24130	COG1160	GTP binding
HRE53_24145	COG0515	serine threonine protein kinase
HRE53_24145	COG3266	domain, Protein
HRE53_24165	COG0326	Molecular chaperone. Has ATPase activity
HRE53_24170	COG4251	negative regulation of phosphorylation
HRE53_24180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE53_24185	COG1185	polyribonucleotide nucleotidyltransferase activity
HRE53_24190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRE53_24255	COG0776	regulation of translation
HRE53_24260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRE53_24270	COG0435	Glutathione S-transferase
HRE53_24275	COG1950	PFAM Membrane protein of
HRE53_24290	COG1846	Transcriptional regulator
HRE53_24295	COG4251	negative regulation of phosphorylation
HRE53_24300	COG0784	Response regulator, receiver
HRE53_24310	COG4251	negative regulation of phosphorylation
HRE53_24335	COG0659	secondary active sulfate transmembrane transporter activity
HRE53_24380	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRE53_24380	COG2273	Hydrolase Family 16
HRE53_24385	COG5002	protein histidine kinase activity
HRE53_24395	COG0523	cobalamin synthesis protein
HRE53_24405	COG1032	radical SAM domain protein
HRE53_24415	COG3394	polysaccharide catabolic process
HRE53_24430	COG0107	imidazoleglycerol-phosphate synthase activity
HRE53_24440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE53_24445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRE53_24455	COG0488	(ABC) transporter
HRE53_24460	COG1801	Protein of unknown function DUF72
HRE53_24465	COG0515	serine threonine protein kinase
HRE53_24480	COG2124	cytochrome p450
HRE53_24485	COG0138	bifunctional purine biosynthesis protein purh
HRE53_24490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_24495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRE53_24500	COG0673	inositol 2-dehydrogenase activity
HRE53_24505	COG0367	asparagine synthase
HRE53_24520	COG2226	methyltransferase
HRE53_24550	COG1216	Glycosyl transferase, family 2
HRE53_24550	COG0438	transferase activity, transferring glycosyl groups
HRE53_24555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_24560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRE53_24565	COG1494	fructose-1,6-bisphosphatase
HRE53_24585	COG0473	3-isopropylmalate dehydrogenase activity
HRE53_24595	COG1131	(ABC) transporter
HRE53_24605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRE53_24610	COG2385	sporulation resulting in formation of a cellular spore
HRE53_24630	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HRE53_24630	COG0662	Cupin 2, conserved barrel domain protein
HRE53_24635	COG0316	Belongs to the HesB IscA family
HRE53_24660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRE53_24670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRE53_24690	COG0438	transferase activity, transferring glycosyl groups
HRE53_24695	COG0438	transferase activity, transferring glycosyl groups
HRE53_24700	COG0489	protein tyrosine kinase activity
HRE53_24725	COG0463	Glycosyl transferase, family 2
HRE53_24725	COG1216	Glycosyl transferase, family 2
HRE53_24730	COG1132	(ABC) transporter
HRE53_24800	COG5002	protein histidine kinase activity
HRE53_24800	COG0784	Response regulator, receiver
HRE53_24830	COG0716	FMN binding
HRE53_24835	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HRE53_24840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_24845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_24850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_24865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRE53_24875	COG2133	pyrroloquinoline quinone binding
HRE53_24885	COG1271	oxidase subunit
HRE53_24930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRE53_24965	COG0405	Gamma-glutamyltransferase
HRE53_24975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRE53_24985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_24995	COG0438	transferase activity, transferring glycosyl groups
HRE53_25015	COG0004	ammonium transporteR
HRE53_25050	COG2988	succinylglutamate desuccinylase activity
HRE53_25065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRE53_25065	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRE53_25100	COG0515	serine threonine protein kinase
HRE53_25100	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_25105	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_25110	COG0306	phosphate transporter
HRE53_25130	COG2198	Histidine kinase
HRE53_25130	COG5002	protein histidine kinase activity
HRE53_25130	COG0784	Response regulator, receiver
HRE53_25150	COG0493	'glutamate synthase
HRE53_25170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRE53_25195	COG0189	ligase activity
HRE53_25200	COG0697	spore germination
HRE53_25220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_25225	COG1254	Belongs to the acylphosphatase family
HRE53_25230	COG0745	RESPONSE REGULATOR receiver
HRE53_25240	COG3328	transposase activity
HRE53_25265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_25275	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRE53_25410	COG0410	ABC transporter
HRE53_25450	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_25510	COG3328	transposase activity
HRE53_25545	COG4191	Histidine kinase
HRE53_25560	COG0784	Response regulator, receiver
HRE53_25560	COG2205	protein histidine kinase activity
HRE53_25565	COG3903	Transcriptional regulator
HRE53_25565	COG2319	Wd-40 repeat
HRE53_25570	COG0644	oxidoreductase
HRE53_25600	COG2197	response regulator
HRE53_25605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRE53_25605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRE53_25625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HRE53_25630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRE53_25635	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRE53_25650	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HRE53_25660	COG0367	asparagine synthase
HRE53_25670	COG2066	Belongs to the glutaminase family
HRE53_25675	COG0517	IMP dehydrogenase activity
HRE53_25675	COG1125	glycine betaine transport
HRE53_25695	COG1484	DNA-dependent DNA replication
HRE53_25725	COG5433	transposase activity
HRE53_25825	COG3335	DDE superfamily endonuclease
HRE53_25870	COG0484	heat shock protein binding
HRE53_25875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_25890	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRE53_26040	COG4251	negative regulation of phosphorylation
HRE53_26050	COG2375	cellular response to nickel ion
HRE53_26075	COG0784	Response regulator, receiver
HRE53_26095	COG5001	Diguanylate cyclase
HRE53_26095	COG5002	protein histidine kinase activity
HRE53_26095	COG3447	MASE1 domain protein
HRE53_26135	COG3920	Histidine kinase
HRE53_26155	COG4999	Histidine kinase
HRE53_26155	COG3850	Histidine kinase
HRE53_26155	COG2205	protein histidine kinase activity
HRE53_26155	COG3437	response regulator, receiver
HRE53_26165	COG3437	response regulator, receiver
HRE53_26220	COG5002	protein histidine kinase activity
HRE53_26220	COG5001	Diguanylate cyclase
HRE53_26310	COG0724	RNA recognition motif
HRE53_26330	COG0745	RESPONSE REGULATOR receiver
HRE53_26345	COG0724	RNA recognition motif
HRE53_26395	COG0515	serine threonine protein kinase
HRE53_26435	COG2205	protein histidine kinase activity
HRE53_26435	COG3437	response regulator, receiver
HRE53_26435	COG3850	Histidine kinase
HRE53_26435	COG4999	Histidine kinase
HRE53_26465	COG4584	PFAM Integrase catalytic
HRE53_26470	COG1484	DNA-dependent DNA replication
HRE53_26475	COG0784	Response regulator, receiver
HRE53_26495	COG3920	Histidine kinase
HRE53_26515	COG3437	response regulator, receiver
HRE53_26530	COG1716	ATPase activity
HRE53_26530	COG5001	Diguanylate cyclase
HRE53_26535	COG2203	Gaf domain
HRE53_26535	COG4251	negative regulation of phosphorylation
HRE53_26535	COG3706	GGDEF domain
HRE53_26535	COG5001	Diguanylate cyclase
HRE53_26545	COG5001	Diguanylate cyclase
HRE53_26545	COG5002	protein histidine kinase activity
HRE53_26550	COG5001	Diguanylate cyclase
HRE53_26550	COG5002	protein histidine kinase activity
HRE53_26565	COG0347	Belongs to the P(II) protein family
HRE53_26570	COG0475	glutathione-regulated potassium exporter activity
HRE53_26575	COG1006	Multisubunit Na H antiporter MnhC subunit
HRE53_26580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_26625	COG0583	DNA-binding transcription factor activity
HRE53_26640	COG4584	PFAM Integrase catalytic
HRE53_26645	COG1484	DNA-dependent DNA replication
HRE53_26690	COG4974	Belongs to the 'phage' integrase family
HRE53_26695	COG4974	Belongs to the 'phage' integrase family
HRE53_26740	COG1484	DNA-dependent DNA replication
HRE53_26745	COG4584	PFAM Integrase catalytic
HRE53_26750	COG4584	PFAM Integrase catalytic
HRE53_26755	COG1309	transcriptional regulator
HRE53_26780	COG2814	Major facilitator Superfamily
HRE53_26785	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_26790	COG1169	isochorismate synthase
HRE53_26795	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRE53_26800	COG3433	isochorismatase activity
HRE53_26800	COG1535	isochorismatase
HRE53_26805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRE53_26805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRE53_26830	COG3335	DDE superfamily endonuclease
HRE53_26880	COG4974	Belongs to the 'phage' integrase family
HRE53_26920	COG2197	response regulator
HRE53_26925	COG2205	protein histidine kinase activity
HRE53_26925	COG0784	Response regulator, receiver
HRE53_26930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HRE53_26935	COG5002	protein histidine kinase activity
HRE53_26940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_26955	COG0589	response to stress
HRE53_26955	COG0475	glutathione-regulated potassium exporter activity
HRE53_26975	COG0189	ligase activity
HRE53_26980	COG4067	protein conserved in archaea
HRE53_26980	COG0189	ligase activity
HRE53_27005	COG1077	Cell shape determining protein MreB Mrl
HRE53_27045	COG0572	uridine kinase
HRE53_27055	COG1475	DNA binding
HRE53_27085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_27220	COG0776	regulation of translation
HRE53_27230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_27260	COG0187	DNA topoisomerase II activity
HRE53_27260	COG1372	Participates in initiation and elongation during chromosome replication
HRE53_27340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_27565	COG1484	DNA-dependent DNA replication
HRE53_27570	COG4584	PFAM Integrase catalytic
HRE53_27615	COG4584	PFAM Integrase catalytic
HRE53_27620	COG1484	DNA-dependent DNA replication
HRE53_27665	COG0724	RNA recognition motif
HRE53_27675	COG1484	DNA-dependent DNA replication
HRE53_27685	COG4584	PFAM Integrase catalytic
HRE53_27710	COG0702	epimerase
HRE53_27730	COG2226	methyltransferase
HRE53_27735	COG0693	protein deglycase activity
HRE53_27795	COG4584	PFAM Integrase catalytic
HRE53_27815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRE53_27820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE53_27820	COG3453	Protein conserved in bacteria
HRE53_27835	COG1475	DNA binding
HRE53_27840	COG1192	Involved in chromosome partitioning
HRE53_27885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_27945	COG0589	response to stress
HRE53_27970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRE53_27980	COG0726	polysaccharide deacetylase
HRE53_28000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_28115	COG0515	serine threonine protein kinase
HRE53_28115	COG2815	serine threonine protein kinase
HRE53_28190	COG2124	cytochrome p450
HRE53_28215	COG1799	cell septum assembly
HRE53_28235	COG0724	RNA recognition motif
HRE53_28255	COG0745	RESPONSE REGULATOR receiver
HRE53_28300	COG1484	DNA-dependent DNA replication
HRE53_28305	COG4584	PFAM Integrase catalytic
HRE53_28310	COG4584	PFAM Integrase catalytic
HRE53_28315	COG1484	DNA-dependent DNA replication
HRE53_28365	COG0745	RESPONSE REGULATOR receiver
HRE53_28375	COG0724	RNA recognition motif
HRE53_28450	COG1555	photosystem II stabilization
HRE53_28465	COG1484	DNA-dependent DNA replication
HRE53_28470	COG1484	DNA-dependent DNA replication
HRE53_28490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRE53_28510	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRE53_28525	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_28530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_28545	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_28555	COG0484	heat shock protein binding
HRE53_28595	COG1484	DNA-dependent DNA replication
HRE53_28600	COG4584	PFAM Integrase catalytic
HRE53_28615	COG5002	protein histidine kinase activity
HRE53_28620	COG0724	RNA recognition motif
HRE53_28630	COG0724	RNA recognition motif
HRE53_28665	COG1077	Cell shape determining protein MreB Mrl
HRE53_28675	COG0205	6-phosphofructokinase activity
HRE53_28680	COG0409	Hydrogenase expression formation protein
HRE53_28690	COG1960	acyl-CoA dehydrogenase activity
HRE53_28695	COG0183	Belongs to the thiolase family
HRE53_28715	COG2267	carboxylic ester hydrolase activity
HRE53_28720	COG0071	Belongs to the small heat shock protein (HSP20) family
HRE53_28765	COG2205	protein histidine kinase activity
HRE53_28765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_28770	COG4251	negative regulation of phosphorylation
HRE53_28775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRE53_28775	COG0574	Belongs to the PEP-utilizing enzyme family
HRE53_28795	COG0475	glutathione-regulated potassium exporter activity
HRE53_28825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRE53_28850	COG0589	response to stress
HRE53_28855	COG0589	response to stress
HRE53_28880	COG1034	ATP synthesis coupled electron transport
HRE53_28885	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_28890	COG0517	IMP dehydrogenase activity
HRE53_28905	COG3259	Nickel-dependent hydrogenase
HRE53_28910	COG0298	carbon dioxide binding
HRE53_28935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRE53_28940	COG0375	protein maturation
HRE53_28975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_29000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRE53_29040	COG4584	PFAM Integrase catalytic
HRE53_29045	COG1484	DNA-dependent DNA replication
HRE53_29065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRE53_29075	COG0569	domain protein
HRE53_29080	COG2204	response regulator
HRE53_29115	COG5002	protein histidine kinase activity
HRE53_29155	COG3437	response regulator, receiver
HRE53_29160	COG2205	protein histidine kinase activity
HRE53_29160	COG0784	Response regulator, receiver
HRE53_29220	COG0058	SHG alpha-glucan phosphorylase activity
HRE53_29240	COG0784	Response regulator, receiver
HRE53_29240	COG2198	Histidine kinase
HRE53_29240	COG2205	protein histidine kinase activity
HRE53_29250	COG3093	addiction module antidote protein HigA
HRE53_29295	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRE53_29295	COG2273	Hydrolase Family 16
HRE53_29300	COG5002	protein histidine kinase activity
HRE53_29305	COG0745	RESPONSE REGULATOR receiver
HRE53_29330	COG5002	protein histidine kinase activity
HRE53_29340	COG0789	Transcriptional regulator
HRE53_29365	COG4974	Belongs to the 'phage' integrase family
HRE53_29380	COG1192	Involved in chromosome partitioning
HRE53_29385	COG1475	DNA binding
HRE53_29550	COG0776	regulation of translation
HRE53_29565	COG1366	Belongs to the anti-sigma-factor antagonist family
HRE53_29590	COG0776	regulation of translation
HRE53_29600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_29785	COG2226	methyltransferase
HRE53_29795	COG0724	RNA recognition motif
HRE53_29840	COG0484	heat shock protein binding
HRE53_29845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_29865	COG0745	RESPONSE REGULATOR receiver
HRE53_29910	COG4572	Cation transport regulator
HRE53_29935	COG0557	exoribonuclease II activity
HRE53_29980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRE53_29995	COG4974	Belongs to the 'phage' integrase family
HRE53_30000	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_30000	COG2319	Wd-40 repeat
HRE53_30030	COG2319	Wd-40 repeat
HRE53_30030	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_30055	COG1672	PFAM Archaeal ATPase
HRE53_30055	COG2319	Wd-40 repeat
HRE53_30075	COG4974	Belongs to the 'phage' integrase family
HRE53_30080	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_30080	COG2319	Wd-40 repeat
HRE53_30150	COG0629	single-stranded DNA binding
HRE53_30235	COG4974	Belongs to the 'phage' integrase family
HRE53_30345	COG3093	addiction module antidote protein HigA
HRE53_30355	COG3903	Transcriptional regulator
HRE53_30355	COG3629	intracellular signal transduction
HRE53_30380	COG4227	nucleotidyltransferase activity
HRE53_30410	COG3093	addiction module antidote protein HigA
HRE53_30470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_30485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_30495	COG1216	Glycosyl transferase, family 2
HRE53_30535	COG0739	heme binding
HRE53_30600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_30615	COG0515	serine threonine protein kinase
HRE53_30615	COG2815	serine threonine protein kinase
HRE53_30680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_30700	COG1475	DNA binding
HRE53_30790	COG3328	transposase activity
HRE53_30805	COG3093	addiction module antidote protein HigA
HRE53_30870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRE53_31030	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_31030	COG0515	serine threonine protein kinase
HRE53_31110	COG1401	restriction endodeoxyribonuclease activity
HRE53_31125	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRE53_31180	COG1476	TRANSCRIPTIONal
HRE53_31250	COG1484	DNA-dependent DNA replication
HRE53_31255	COG4584	PFAM Integrase catalytic
HRE53_31290	COG1192	Involved in chromosome partitioning
HRE53_31295	COG1475	DNA binding
HRE53_31320	COG1525	nuclease
HRE53_31375	COG2815	serine threonine protein kinase
HRE53_31375	COG0515	serine threonine protein kinase
HRE53_31545	COG3093	addiction module antidote protein HigA
HRE53_31600	COG1078	dGTPase activity
HRE53_31620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_31625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_31630	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_31655	COG2329	Antibiotic biosynthesis monooxygenase
HRE53_31660	COG1309	transcriptional regulator
HRE53_31690	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRE53_31780	COG1799	cell septum assembly
HRE53_31790	COG0724	RNA recognition motif
HRE53_31795	COG0724	RNA recognition motif
HRE53_31800	COG0542	response to heat
HRE53_31810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_31980	COG0515	serine threonine protein kinase
HRE53_31980	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_32025	COG3093	addiction module antidote protein HigA
HRE53_32075	COG1484	DNA-dependent DNA replication
HRE53_32095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRE53_32095	COG0515	serine threonine protein kinase
HRE53_32105	COG1484	DNA-dependent DNA replication
HRE53_32165	COG3328	transposase activity
HRE53_32200	COG3328	transposase activity
HRE53_32210	COG1484	DNA-dependent DNA replication
HRE53_32215	COG4584	PFAM Integrase catalytic
HRE53_32220	COG4584	PFAM Integrase catalytic
HRE53_32225	COG2201	protein-glutamate methylesterase activity
HRE53_32265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_32275	COG0557	exoribonuclease II activity
HRE53_32350	COG2226	methyltransferase
HRE53_32365	COG1476	TRANSCRIPTIONal
HRE53_32525	COG1484	DNA-dependent DNA replication
HRE53_32550	COG2319	Wd-40 repeat
HRE53_32550	COG3903	Transcriptional regulator
HRE53_32555	COG3903	Transcriptional regulator
HRE53_32555	COG2319	Wd-40 repeat
HRE53_32560	COG2319	Wd-40 repeat
HRE53_32560	COG3903	Transcriptional regulator
HRE53_32620	COG0724	RNA recognition motif
HRE53_32660	COG1216	Glycosyl transferase, family 2
HRE53_32670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_32885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRE53_32950	COG0515	serine threonine protein kinase
HRE53_32965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_33055	COG0739	heme binding
HRE53_33130	COG1192	Involved in chromosome partitioning
HRE53_33220	COG1404	Belongs to the peptidase S8 family
HRE53_33275	COG3328	transposase activity