locus-tag	class	description
HVS_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HVS_00010	COG0592	DNA-directed DNA polymerase activity
HVS_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HVS_00030	COG0187	DNA topoisomerase II activity
HVS_00035	COG1192	Involved in chromosome partitioning
HVS_00040	COG1475	DNA binding
HVS_00055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HVS_00070	COG1183	phosphatidylcholine synthase activity
HVS_00080	COG2373	Large extracellular alpha-helical protein
HVS_00090	COG2720	vancomycin resistance protein
HVS_00110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVS_00120	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_00125	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_00155	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HVS_00175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HVS_00180	COG1802	Transcriptional regulator
HVS_00195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVS_00215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HVS_00225	COG2959	enzyme of heme biosynthesis
HVS_00235	COG1484	DNA-dependent DNA replication
HVS_00250	COG1653	transport
HVS_00260	COG1175	transmembrane transport
HVS_00265	COG0395	ABC-type sugar transport system, permease component
HVS_00270	COG3275	phosphorelay sensor kinase activity
HVS_00275	COG3279	Response regulator of the LytR AlgR family
HVS_00315	COG1595	DNA-templated transcription, initiation
HVS_00320	COG3693	PFAM glycoside hydrolase, family 10
HVS_00325	COG1361	Conserved repeat domain
HVS_00350	COG3848	Pyruvate phosphate dikinase
HVS_00350	COG0574	Belongs to the PEP-utilizing enzyme family
HVS_00360	COG0688	phosphatidylethanolamine metabolic process
HVS_00370	COG0574	Belongs to the PEP-utilizing enzyme family
HVS_00370	COG3848	Pyruvate phosphate dikinase
HVS_00380	COG0840	transmembrane signaling receptor activity
HVS_00405	COG0693	protein deglycase activity
HVS_00410	COG0667	Aldo Keto reductase
HVS_00415	COG0546	phosphoglycolate phosphatase activity
HVS_00440	COG4942	peptidase
HVS_00440	COG1418	mRNA catabolic process
HVS_00460	COG2208	phosphoserine phosphatase activity
HVS_00470	COG2382	esterase
HVS_00470	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_00470	COG3693	PFAM glycoside hydrolase, family 10
HVS_00475	COG2382	esterase
HVS_00475	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_00475	COG3693	PFAM glycoside hydrolase, family 10
HVS_00495	COG4786	Flagellar basal body rod
HVS_00510	COG0840	transmembrane signaling receptor activity
HVS_00515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HVS_00520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVS_00530	COG2088	sporulation resulting in formation of a cellular spore
HVS_00535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HVS_00545	COG0193	aminoacyl-tRNA hydrolase activity
HVS_00550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVS_00555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVS_00560	COG2002	toxin-antitoxin pair type II binding
HVS_00565	COG3956	TIGRFAM MazG family protein
HVS_00570	COG0776	regulation of translation
HVS_00575	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVS_00595	COG1098	S1 RNA binding domain
HVS_00600	COG2897	thiosulfate sulfurtransferase activity
HVS_00605	COG0668	transmembrane transport
HVS_00610	COG1388	LysM domain
HVS_00610	COG3942	CHAP domain
HVS_00640	COG1773	rubredoxin
HVS_00650	COG1366	Belongs to the anti-sigma-factor antagonist family
HVS_00660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVS_00665	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HVS_00670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HVS_00750	COG3464	Transposase
HVS_00810	COG3464	Transposase
HVS_00880	COG3266	domain, Protein
HVS_00880	COG1361	Conserved repeat domain
HVS_00880	COG2911	Protein conserved in bacteria
HVS_01085	COG3328	transposase activity
HVS_01100	COG3464	Transposase
HVS_01110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_01160	COG1361	Conserved repeat domain
HVS_01170	COG0590	tRNA wobble adenosine to inosine editing
HVS_01175	COG0028	Belongs to the TPP enzyme family
HVS_01180	COG0440	acetolactate synthase activity
HVS_01185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HVS_01190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVS_01195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVS_01200	COG1191	sigma factor activity
HVS_01205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVS_01210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVS_01225	COG0629	single-stranded DNA binding
HVS_01230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVS_01235	COG1295	ribonuclease BN
HVS_01240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVS_01265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVS_01270	COG0254	rRNA binding
HVS_01280	COG1394	ATPase activity, coupled to movement of substances
HVS_01285	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HVS_01290	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HVS_01300	COG1527	subunit (C
HVS_01305	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HVS_01310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HVS_01315	COG1269	ATP hydrolysis coupled proton transport
HVS_01325	COG1605	Chorismate mutase
HVS_01325	COG0077	Prephenate dehydratase
HVS_01335	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HVS_01340	COG0359	binds to the 23S rRNA
HVS_01345	COG0305	Participates in initiation and elongation during chromosome replication
HVS_01350	COG0037	tRNA processing
HVS_01355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVS_01360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVS_01365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HVS_01390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVS_01395	COG1040	competence protein
HVS_01415	COG4786	Flagellar basal body rod
HVS_01415	COG1256	bacterial-type flagellum assembly
HVS_01425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVS_01435	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HVS_01440	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVS_01455	COG2604	Protein of unknown function DUF115
HVS_01460	COG1086	Polysaccharide biosynthesis protein
HVS_01465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HVS_01475	COG2089	acid synthase
HVS_01480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HVS_01500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVS_01505	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_01510	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HVS_01580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVS_01590	COG0732	type I restriction modification DNA specificity domain
HVS_01595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HVS_01615	COG1802	Transcriptional regulator
HVS_01615	COG4626	Terminase
HVS_01630	COG1164	Oligoendopeptidase f
HVS_01645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVS_01650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVS_01655	COG1121	(ABC) transporter
HVS_01660	COG0803	Belongs to the bacterial solute-binding protein 9 family
HVS_01665	COG2239	Acts as a magnesium transporter
HVS_01670	COG0590	tRNA wobble adenosine to inosine editing
HVS_01685	COG2878	Part of a membrane complex involved in electron transport
HVS_01685	COG1245	4Fe-4S binding domain
HVS_01690	COG4657	Part of a membrane complex involved in electron transport
HVS_01695	COG4660	Part of a membrane complex involved in electron transport
HVS_01705	COG4658	electron transport chain
HVS_01710	COG4656	Part of a membrane complex involved in electron transport
HVS_01715	COG2890	protein-(glutamine-N5) methyltransferase activity
HVS_01720	COG3872	metal-dependent enzyme
HVS_01745	COG3291	Pkd domain containing protein
HVS_01765	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVS_01770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HVS_01780	COG0018	arginyl-trna synthetase
HVS_01800	COG0793	Belongs to the peptidase S41A family
HVS_01805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVS_01815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HVS_01820	COG2183	response to ionizing radiation
HVS_01850	COG0785	Cytochrome C biogenesis protein
HVS_01855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVS_01870	COG0492	ferredoxin-NADP+ reductase activity
HVS_01920	COG3547	Transposase (IS116 IS110 IS902 family)
HVS_01945	COG1361	Conserved repeat domain
HVS_01950	COG3344	reverse transcriptase
HVS_01990	COG3464	Transposase
HVS_02210	COG1131	(ABC) transporter
HVS_02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVS_02255	COG1131	(ABC) transporter
HVS_02310	COG2217	Heavy metal translocating P-type atpase
HVS_02315	COG0658	competence protein
HVS_02315	COG2333	competence protein COMEC
HVS_02325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HVS_02340	COG0246	Mannitol dehydrogenase
HVS_02345	COG1312	Catalyzes the dehydration of D-mannonate
HVS_02350	COG0800	Aldolase
HVS_02365	COG4753	response regulator
HVS_02365	COG2207	Transcriptional regulator
HVS_02370	COG2972	Histidine kinase
HVS_02375	COG2207	Transcriptional regulator
HVS_02375	COG4753	response regulator
HVS_02375	COG2207	Transcriptional regulator
HVS_02375	COG4753	response regulator
HVS_02385	COG4209	transmembrane transport
HVS_02390	COG0395	ABC-type sugar transport system, permease component
HVS_02400	COG1472	Belongs to the glycosyl hydrolase 3 family
HVS_02405	COG1070	Carbohydrate kinase
HVS_02425	COG0628	permease
HVS_02430	COG0194	GDP metabolic process
HVS_02435	COG0133	tryptophan synthase activity
HVS_02440	COG0159	tryptophan synthase activity
HVS_02445	COG1361	Conserved repeat domain
HVS_02445	COG3266	domain, Protein
HVS_02445	COG2911	Protein conserved in bacteria
HVS_02460	COG3409	Peptidoglycan-binding domain 1 protein
HVS_02460	COG3773	Cell wall hydrolase
HVS_02470	COG0372	Belongs to the citrate synthase family
HVS_02475	COG3279	Response regulator of the LytR AlgR family
HVS_02495	COG3852	Histidine kinase
HVS_02505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVS_02510	COG4224	UPF0291 protein
HVS_02520	COG0714	Associated with various cellular activities
HVS_02530	COG1305	Transglutaminase-like
HVS_02540	COG1674	ftsk spoiiie
HVS_02545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVS_02565	COG0768	penicillin binding
HVS_02570	COG0688	phosphatidylethanolamine metabolic process
HVS_02575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVS_02580	COG4447	cellulose binding
HVS_02580	COG4733	cellulase activity
HVS_02585	COG2911	Protein conserved in bacteria
HVS_02590	COG3266	domain, Protein
HVS_02590	COG2911	Protein conserved in bacteria
HVS_02590	COG1361	Conserved repeat domain
HVS_02595	COG3266	domain, Protein
HVS_02595	COG1361	Conserved repeat domain
HVS_02595	COG2911	Protein conserved in bacteria
HVS_02600	COG1361	Conserved repeat domain
HVS_02605	COG1361	Conserved repeat domain
HVS_02635	COG0542	response to heat
HVS_02660	COG1472	Belongs to the glycosyl hydrolase 3 family
HVS_02685	COG0525	valine-tRNA ligase activity
HVS_02710	COG0113	porphobilinogen synthase activity
HVS_02715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HVS_02720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVS_02720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HVS_02730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVS_02735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVS_02740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVS_02760	COG2873	o-acetylhomoserine
HVS_02775	COG0175	sulfate reduction
HVS_02800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HVS_02805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HVS_02815	COG2172	sigma factor antagonist activity
HVS_02835	COG3464	Transposase
HVS_02840	COG2357	RelA SpoT domain protein
HVS_02845	COG1121	(ABC) transporter
HVS_02855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HVS_02860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HVS_02875	COG1484	DNA-dependent DNA replication
HVS_02880	COG4584	PFAM Integrase catalytic
HVS_02930	COG3464	Transposase
HVS_02945	COG0640	Transcriptional regulator
HVS_02950	COG1131	(ABC) transporter
HVS_02965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_03005	COG0640	Transcriptional regulator
HVS_03010	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HVS_03015	COG3682	Transcriptional regulator
HVS_03025	COG3209	COG3209 Rhs family protein
HVS_03045	COG3464	Transposase
HVS_03060	COG3620	sequence-specific DNA binding
HVS_03095	COG0745	RESPONSE REGULATOR receiver
HVS_03105	COG1131	(ABC) transporter
HVS_03145	COG2207	Transcriptional regulator
HVS_03145	COG3708	Transcriptional regulator
HVS_03160	COG0745	RESPONSE REGULATOR receiver
HVS_03175	COG2205	protein histidine kinase activity
HVS_03205	COG3328	transposase activity
HVS_03230	COG1361	Conserved repeat domain
HVS_03250	COG1228	amidohydrolase
HVS_03255	COG0802	atpase or kinase
HVS_03260	COG1214	PFAM Peptidase M22, glycoprotease
HVS_03265	COG0456	acetyltransferase
HVS_03270	COG1067	ATP-dependent peptidase activity
HVS_03285	COG0210	DNA helicase
HVS_03300	COG1611	Belongs to the LOG family
HVS_03340	COG0739	heme binding
HVS_03350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVS_03355	COG1120	ATPase activity
HVS_03380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_03385	COG1368	sulfuric ester hydrolase activity
HVS_03400	COG4305	rare lipoprotein A
HVS_03410	COG3464	Transposase
HVS_03415	COG2002	toxin-antitoxin pair type II binding
HVS_03435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVS_03440	COG0066	3-isopropylmalate dehydratase activity
HVS_03445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVS_03460	COG3775	system Galactitol-specific IIC component
HVS_03485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVS_03530	COG3501	Rhs element vgr protein
HVS_03530	COG3409	Peptidoglycan-binding domain 1 protein
HVS_03680	COG0640	Transcriptional regulator
HVS_03690	COG3464	Transposase
HVS_03695	COG1404	Belongs to the peptidase S8 family
HVS_03700	COG1404	Belongs to the peptidase S8 family
HVS_03720	COG3464	Transposase
HVS_03730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HVS_03740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HVS_03745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HVS_03750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HVS_03755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HVS_03765	COG0629	single-stranded DNA binding
HVS_03770	COG1408	metallophosphoesterase
HVS_03795	COG1518	maintenance of DNA repeat elements
HVS_03810	COG1196	nuclear chromosome segregation
HVS_03810	COG0739	heme binding
HVS_03810	COG0741	lytic transglycosylase activity
HVS_03820	COG1937	Protein conserved in bacteria
HVS_03830	COG2217	Heavy metal translocating P-type atpase
HVS_03845	COG1361	Conserved repeat domain
HVS_03850	COG2911	Protein conserved in bacteria
HVS_04105	COG3464	Transposase
HVS_04185	COG1811	Na channel or pump
HVS_04195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HVS_04225	COG4733	cellulase activity
HVS_04230	COG4733	cellulase activity
HVS_04230	COG4447	cellulose binding
HVS_04235	COG0673	inositol 2-dehydrogenase activity
HVS_04245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVS_04250	COG0514	ATP-dependent DNA helicase (RecQ)
HVS_04255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HVS_04270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HVS_04275	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HVS_04280	COG0438	transferase activity, transferring glycosyl groups
HVS_04285	COG3973	AAA domain
HVS_04290	COG0484	heat shock protein binding
HVS_04295	COG0542	response to heat
HVS_04305	COG4372	Transposase
HVS_04320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_04350	COG1361	Conserved repeat domain
HVS_04350	COG3266	domain, Protein
HVS_04350	COG2911	Protein conserved in bacteria
HVS_04410	COG3464	Transposase
HVS_04415	COG3464	Transposase
HVS_04430	COG5433	transposase activity
HVS_04450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_04460	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_04465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HVS_04475	COG4310	Domain of unknown function (DUF2172)
HVS_04485	COG2089	acid synthase
HVS_04515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVS_04520	COG1088	dTDP-glucose 4,6-dehydratase activity
HVS_04590	COG0697	spore germination
HVS_04600	COG1136	(ABC) transporter
HVS_04610	COG1136	(ABC) transporter
HVS_04610	COG0577	efflux transmembrane transporter activity
HVS_04620	COG0697	spore germination
HVS_04645	COG4974	Belongs to the 'phage' integrase family
HVS_04675	COG3464	Transposase
HVS_04710	COG4626	Terminase
HVS_04710	COG1802	Transcriptional regulator
HVS_04725	COG4695	Portal protein
HVS_04760	COG1131	(ABC) transporter
HVS_04775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HVS_04790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_04835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVS_04840	COG1191	sigma factor activity
HVS_04845	COG2755	lipolytic protein G-D-S-L family
HVS_04885	COG3866	Pectate lyase
HVS_04890	COG1609	Transcriptional regulator
HVS_04905	COG0318	PFAM AMP-dependent synthetase and ligase
HVS_04915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVS_04935	COG1131	(ABC) transporter
HVS_04965	COG4447	cellulose binding
HVS_04965	COG4733	cellulase activity
HVS_04980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HVS_04990	COG1518	maintenance of DNA repeat elements
HVS_05070	COG2323	membrane
HVS_05080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_05105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HVS_05110	COG1686	Belongs to the peptidase S11 family
HVS_05135	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVS_05150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HVS_05155	COG0248	Ppx GppA phosphatase
HVS_05155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HVS_05160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVS_05165	COG0116	Belongs to the methyltransferase superfamily
HVS_05165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HVS_05170	COG0564	pseudouridine synthase activity
HVS_05180	COG0297	glycogen (starch) synthase activity
HVS_05195	COG1482	cell wall glycoprotein biosynthetic process
HVS_05210	COG2197	response regulator
HVS_05215	COG3328	transposase activity
HVS_05235	COG1331	Highly conserved protein containing a thioredoxin domain
HVS_05240	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVS_05245	COG1489	DNA binding
HVS_05250	COG2340	Cysteine-rich secretory protein family
HVS_05260	COG0187	DNA topoisomerase II activity
HVS_05270	COG0473	3-isopropylmalate dehydrogenase activity
HVS_05280	COG1690	Belongs to the RtcB family
HVS_05290	COG0556	nucleotide-excision repair
HVS_05295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVS_05300	COG2502	aspartate--ammonia ligase
HVS_05305	COG0017	Asparaginyl-tRNA synthetase
HVS_05310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVS_05315	COG0390	transport system, permease component
HVS_05335	COG2059	Chromate
HVS_05350	COG1595	DNA-templated transcription, initiation
HVS_05370	COG0835	chemotaxis
HVS_05375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HVS_05380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_05405	COG0424	maF-like protein
HVS_05410	COG1077	Cell shape determining protein MreB Mrl
HVS_05425	COG0768	penicillin binding
HVS_05430	COG0850	regulation of cytokinetic process
HVS_05435	COG2894	cell division
HVS_05440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HVS_05445	COG1803	Methylglyoxal synthase
HVS_05455	COG1994	Peptidase M50
HVS_05460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVS_05475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HVS_05475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HVS_05480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HVS_05490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HVS_05495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HVS_05515	COG3464	Transposase
HVS_05525	COG2323	membrane
HVS_05530	COG0569	domain protein
HVS_05540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVS_05580	COG0631	protein serine/threonine phosphatase activity
HVS_05590	COG3464	Transposase
HVS_05600	COG1132	(ABC) transporter
HVS_05605	COG1132	(ABC) transporter
HVS_05610	COG1132	(ABC) transporter
HVS_05675	COG1674	ftsk spoiiie
HVS_05690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_05795	COG3328	transposase activity
HVS_05905	COG0515	serine threonine protein kinase
HVS_05920	COG1686	Belongs to the peptidase S11 family
HVS_05945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HVS_05985	COG0628	permease
HVS_06035	COG3344	reverse transcriptase
HVS_06060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVS_06065	COG1516	flagellar protein fliS
HVS_06075	COG1073	alpha beta
HVS_06080	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HVS_06085	COG2207	Transcriptional regulator
HVS_06095	COG1361	Conserved repeat domain
HVS_06095	COG2911	Protein conserved in bacteria
HVS_06095	COG3266	domain, Protein
HVS_06115	COG1191	sigma factor activity
HVS_06120	COG0473	3-isopropylmalate dehydrogenase activity
HVS_06125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVS_06135	COG0302	gtp cyclohydrolase
HVS_06165	COG1496	oxidoreductase activity
HVS_06175	COG3464	Transposase
HVS_06180	COG0537	adenosine 5'-monophosphoramidase activity
HVS_06185	COG1361	Conserved repeat domain
HVS_06200	COG0489	protein tyrosine kinase activity
HVS_06215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVS_06225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HVS_06235	COG1022	Amp-dependent synthetase and ligase
HVS_06275	COG1132	(ABC) transporter
HVS_06290	COG0519	Catalyzes the synthesis of GMP from XMP
HVS_06305	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVS_06310	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HVS_06315	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVS_06320	COG0138	bifunctional purine biosynthesis protein purh
HVS_06325	COG0151	Belongs to the GarS family
HVS_06335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HVS_06340	COG1713	HD superfamily hydrolase involved in NAD metabolism
HVS_06345	COG0799	negative regulation of ribosome biogenesis
HVS_06350	COG0495	leucyl-tRNA aminoacylation
HVS_06355	COG1686	Belongs to the peptidase S11 family
HVS_06360	COG1555	photosystem II stabilization
HVS_06360	COG1596	polysaccharide export
HVS_06385	COG2373	Large extracellular alpha-helical protein
HVS_06400	COG0768	penicillin binding
HVS_06405	COG0826	peptidase U32
HVS_06410	COG4122	O-methyltransferase activity
HVS_06415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVS_06420	COG1217	gtp-binding protein TYPA
HVS_06430	COG0052	Belongs to the universal ribosomal protein uS2 family
HVS_06435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HVS_06440	COG0528	UMP kinase activity
HVS_06445	COG0233	cytoplasmic translational termination
HVS_06460	COG0575	Belongs to the CDS family
HVS_06465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVS_06470	COG0750	zinc metalloprotease
HVS_06475	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HVS_06480	COG0463	Glycosyl transferase, family 2
HVS_06485	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HVS_06490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HVS_06495	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HVS_06500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVS_06505	COG3459	Glycosyltransferase 36 associated
HVS_06525	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HVS_06530	COG0542	response to heat
HVS_06535	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HVS_06545	COG1686	Belongs to the peptidase S11 family
HVS_06550	COG1509	lysine 2,3-aminomutase activity
HVS_06555	COG0456	acetyltransferase
HVS_06560	COG3870	Protein conserved in bacteria
HVS_06570	COG3885	ferrous iron binding
HVS_06570	COG2078	PFAM AMMECR1 domain protein
HVS_06580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HVS_06590	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HVS_06595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVS_06600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVS_06630	COG3328	transposase activity
HVS_06635	COG3464	Transposase
HVS_06645	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVS_06680	COG0514	ATP-dependent DNA helicase (RecQ)
HVS_06685	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVS_06695	COG3586	endonuclease activity
HVS_06700	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HVS_06750	COG1956	GAF domain-containing protein
HVS_06790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVS_06885	COG3464	Transposase
HVS_06970	COG0626	cystathionine gamma-synthase activity
HVS_06995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVS_07005	COG0730	response to heat
HVS_07010	COG0730	response to heat
HVS_07025	COG4447	cellulose binding
HVS_07025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_07035	COG3326	Membrane
HVS_07040	COG0668	transmembrane transport
HVS_07045	COG0708	Exodeoxyribonuclease III
HVS_07055	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_07065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVS_07085	COG3547	Transposase (IS116 IS110 IS902 family)
HVS_07115	COG0726	polysaccharide deacetylase
HVS_07145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVS_07150	COG0242	peptide deformylase activity
HVS_07155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HVS_07165	COG2738	Putative neutral zinc metallopeptidase
HVS_07170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HVS_07170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HVS_07175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HVS_07180	COG0631	protein serine/threonine phosphatase activity
HVS_07185	COG2815	serine threonine protein kinase
HVS_07185	COG0515	serine threonine protein kinase
HVS_07190	COG1162	GTPase activity
HVS_07195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVS_07210	COG0436	Aminotransferase
HVS_07215	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HVS_07225	COG2204	response regulator
HVS_07235	COG1030	water channel activity
HVS_07260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HVS_07265	COG2022	thiamine diphosphate biosynthetic process
HVS_07265	COG2104	thiamine diphosphate biosynthetic process
HVS_07270	COG2022	thiamine diphosphate biosynthetic process
HVS_07275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVS_07285	COG0352	thiamine-phosphate diphosphorylase activity
HVS_07290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HVS_07300	COG0791	NLP P60 protein
HVS_07305	COG2333	competence protein COMEC
HVS_07305	COG0658	competence protein
HVS_07310	COG1466	dna polymerase III delta subunit
HVS_07315	COG0268	Binds directly to 16S ribosomal RNA
HVS_07325	COG3464	Transposase
HVS_07330	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVS_07330	COG2247	cell wall binding repeat
HVS_07340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HVS_07365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HVS_07375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HVS_07385	COG0280	phosphate acetyltransferase
HVS_07390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVS_07400	COG1674	ftsk spoiiie
HVS_07405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HVS_07415	COG1418	mRNA catabolic process
HVS_07420	COG1692	metallophosphoesterase
HVS_07425	COG2359	stage V sporulation protein S
HVS_07435	COG1606	tRNA processing
HVS_07455	COG0438	transferase activity, transferring glycosyl groups
HVS_07460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVS_07465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVS_07480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HVS_07485	COG3879	Bacterial protein of unknown function (DUF881)
HVS_07530	COG1702	phosphate starvation-inducible protein PhoH
HVS_07535	COG1480	7TM receptor with intracellular HD hydrolase
HVS_07540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HVS_07545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVS_07550	COG0295	cytidine deaminase activity
HVS_07555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HVS_07565	COG1381	Involved in DNA repair and RecF pathway recombination
HVS_07575	COG1484	DNA-dependent DNA replication
HVS_07580	COG4584	PFAM Integrase catalytic
HVS_07590	COG0301	tRNA thio-modification
HVS_07595	COG2720	vancomycin resistance protein
HVS_07605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HVS_07615	COG0714	Associated with various cellular activities
HVS_07620	COG1305	Transglutaminase-like
HVS_07625	COG0039	L-malate dehydrogenase activity
HVS_07635	COG1546	Belongs to the CinA family
HVS_07635	COG1058	Belongs to the CinA family
HVS_07640	COG0728	peptidoglycan biosynthetic process
HVS_07645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HVS_07680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HVS_07715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVS_07730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVS_07735	COG0134	indole-3-glycerol-phosphate synthase activity
HVS_07745	COG0135	phosphoribosylanthranilate isomerase activity
HVS_07755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVS_07800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVS_07800	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_07805	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_07825	COG4864	UPF0365 protein
HVS_07830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVS_07835	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HVS_07840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVS_07865	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVS_07895	COG3541	Predicted nucleotidyltransferase
HVS_07905	COG3940	Belongs to the glycosyl hydrolase 43 family
HVS_07915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVS_07920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVS_07940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVS_07945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVS_07950	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_07950	COG3250	beta-galactosidase activity
HVS_07955	COG3266	domain, Protein
HVS_07955	COG2911	Protein conserved in bacteria
HVS_07955	COG1361	Conserved repeat domain
HVS_07960	COG1361	Conserved repeat domain
HVS_07960	COG3266	domain, Protein
HVS_07960	COG2911	Protein conserved in bacteria
HVS_07970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HVS_07980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVS_07985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVS_08000	COG1959	2 iron, 2 sulfur cluster binding
HVS_08030	COG3853	Toxic anion resistance protein (TelA)
HVS_08045	COG2310	stress, protein
HVS_08050	COG2310	stress, protein
HVS_08055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVS_08065	COG1358	cellular component organization or biogenesis
HVS_08085	COG3693	PFAM glycoside hydrolase, family 10
HVS_08090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVS_08095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVS_08100	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_08105	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_08135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HVS_08140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HVS_08145	COG4974	Belongs to the 'phage' integrase family
HVS_08155	COG1362	aminopeptidase activity
HVS_08160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVS_08160	COG2199	diguanylate cyclase activity
HVS_08170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HVS_08175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HVS_08180	COG0482	sulfurtransferase activity
HVS_08185	COG0822	iron-sulfur transferase activity
HVS_08200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVS_08205	COG0105	UTP biosynthetic process
HVS_08210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HVS_08215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HVS_08215	COG0539	negative regulation of cytoplasmic translation
HVS_08220	COG0204	Acyl-transferase
HVS_08225	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HVS_08230	COG4401	Chorismate mutase type I
HVS_08245	COG2081	HI0933 family
HVS_08270	COG4447	cellulose binding
HVS_08270	COG4733	cellulase activity
HVS_08285	COG0511	ligase activity, forming carbon-carbon bonds
HVS_08290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HVS_08300	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVS_08305	COG0010	Belongs to the arginase family
HVS_08310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HVS_08355	COG1187	pseudouridine synthase activity
HVS_08360	COG3874	Sporulation protein YtfJ
HVS_08370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HVS_08375	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HVS_08380	COG0180	Tryptophanyl-tRNA synthetase
HVS_08385	COG1994	Peptidase M50
HVS_08390	COG0617	tRNA 3'-terminal CCA addition
HVS_08390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HVS_08390	COG3620	sequence-specific DNA binding
HVS_08400	COG1368	sulfuric ester hydrolase activity
HVS_08500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_08520	COG0336	Belongs to the RNA methyltransferase TrmD family
HVS_08525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HVS_08530	COG1837	Belongs to the UPF0109 family
HVS_08535	COG0228	four-way junction DNA binding
HVS_08540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVS_08545	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HVS_08550	COG0569	domain protein
HVS_08550	COG0189	ligase activity
HVS_08555	COG0189	ligase activity
HVS_08560	COG1388	LysM domain
HVS_08565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVS_08570	COG1923	regulation of RNA biosynthetic process
HVS_08575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HVS_08580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HVS_08585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HVS_08600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HVS_08605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HVS_08620	COG1686	Belongs to the peptidase S11 family
HVS_08625	COG1686	Belongs to the peptidase S11 family
HVS_08635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HVS_08670	COG1725	Transcriptional regulator
HVS_08680	COG0546	phosphoglycolate phosphatase activity
HVS_08710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVS_08715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVS_08720	COG0156	8-amino-7-oxononanoate synthase activity
HVS_08725	COG2267	carboxylic ester hydrolase activity
HVS_08730	COG4106	trans-aconitate 2-methyltransferase activity
HVS_08735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVS_08740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVS_08755	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HVS_08760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVS_08775	COG1570	exodeoxyribonuclease VII activity
HVS_08780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HVS_08795	COG1302	Protein conserved in bacteria
HVS_08835	COG3854	ATPases associated with a variety of cellular activities
HVS_08845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HVS_08850	COG0006	proline dipeptidase activity
HVS_08855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HVS_08860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HVS_08870	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVS_08880	COG0012	GTP binding
HVS_08890	COG0772	Belongs to the SEDS family
HVS_08895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HVS_08900	COG3706	GGDEF domain
HVS_08920	COG0237	dephospho-CoA kinase activity
HVS_08925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVS_08925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVS_08940	COG0552	protein localization to endoplasmic reticulum
HVS_08950	COG2359	stage V sporulation protein S
HVS_08960	COG0571	ribonuclease III activity
HVS_08965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVS_08970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVS_08975	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_08980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVS_08985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_08990	COG0416	fatty acid biosynthetic process
HVS_08995	COG2030	dehydratase
HVS_09000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVS_09005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HVS_09025	COG0406	alpha-ribazole phosphatase activity
HVS_09035	COG3693	PFAM glycoside hydrolase, family 10
HVS_09035	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_09035	COG2382	esterase
HVS_09045	COG0167	dihydroorotate dehydrogenase activity
HVS_09050	COG0543	2 iron, 2 sulfur cluster binding
HVS_09060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HVS_09065	COG0540	Belongs to the ATCase OTCase family
HVS_09075	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HVS_09110	COG1862	Preprotein translocase
HVS_09115	COG0343	queuine tRNA-ribosyltransferase activity
HVS_09120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HVS_09125	COG2247	cell wall binding repeat
HVS_09125	COG2385	sporulation resulting in formation of a cellular spore
HVS_09130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVS_09135	COG0527	aspartate kinase activity
HVS_09140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HVS_09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HVS_09150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVS_09180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVS_09185	COG1191	sigma factor activity
HVS_09205	COG2273	Hydrolase Family 16
HVS_09215	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_09220	COG3693	PFAM glycoside hydrolase, family 10
HVS_09220	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_09220	COG2382	esterase
HVS_09225	COG4978	Transcriptional regulator
HVS_09225	COG0789	Transcriptional regulator
HVS_09270	COG0534	Mate efflux family protein
HVS_09290	COG0714	Associated with various cellular activities
HVS_09305	COG1131	(ABC) transporter
HVS_09320	COG2188	Transcriptional regulator
HVS_09325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVS_09340	COG1484	DNA-dependent DNA replication
HVS_09345	COG4584	PFAM Integrase catalytic
HVS_09350	COG0628	permease
HVS_09355	COG2003	Belongs to the UPF0758 family
HVS_09360	COG0792	nuclease activity
HVS_09365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVS_09375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HVS_09380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HVS_09390	COG3464	Transposase
HVS_09395	COG0335	large ribosomal subunit rRNA binding
HVS_09400	COG4447	cellulose binding
HVS_09400	COG4733	cellulase activity
HVS_09405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVS_09435	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVS_09440	COG0358	DNA primase activity
HVS_09445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HVS_09460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HVS_09465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HVS_09470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HVS_09475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVS_09480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVS_09485	COG1418	mRNA catabolic process
HVS_09500	COG0564	pseudouridine synthase activity
HVS_09505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HVS_09525	COG4124	Belongs to the glycosyl hydrolase 26 family
HVS_09555	COG0840	transmembrane signaling receptor activity
HVS_09600	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_09600	COG2755	lipolytic protein G-D-S-L family
HVS_09610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVS_09640	COG0714	Associated with various cellular activities
HVS_09660	COG1686	Belongs to the peptidase S11 family
HVS_09665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HVS_09670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVS_09675	COG4974	Belongs to the 'phage' integrase family
HVS_09680	COG1300	Membrane
HVS_09685	COG0494	nUDIX hydrolase
HVS_09690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVS_09715	COG0697	spore germination
HVS_09740	COG1509	lysine 2,3-aminomutase activity
HVS_09745	COG0328	RNA-DNA hybrid ribonuclease activity
HVS_09750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVS_09780	COG3599	regulation of cell shape
HVS_09790	COG1799	cell septum assembly
HVS_09795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVS_09805	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HVS_09810	COG0564	pseudouridine synthase activity
HVS_09820	COG0745	RESPONSE REGULATOR receiver
HVS_09825	COG2205	protein histidine kinase activity
HVS_09825	COG4999	Histidine kinase
HVS_09825	COG3850	Histidine kinase
HVS_09825	COG3437	response regulator, receiver
HVS_09830	COG2201	protein-glutamate methylesterase activity
HVS_09840	COG0835	chemotaxis
HVS_09845	COG0643	Histidine kinase
HVS_09845	COG2198	Histidine kinase
HVS_09850	COG2201	protein-glutamate methylesterase activity
HVS_09855	COG0745	RESPONSE REGULATOR receiver
HVS_09860	COG0750	zinc metalloprotease
HVS_09865	COG2755	lipolytic protein G-D-S-L family
HVS_09865	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_09890	COG0497	DNA recombination
HVS_09895	COG1438	arginine binding
HVS_09900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HVS_09905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVS_09945	COG0463	Glycosyl transferase, family 2
HVS_09945	COG0457	Tetratricopeptide repeat
HVS_09965	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_09970	COG1083	cytidylyl-transferase
HVS_09980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HVS_09990	COG2089	acid synthase
HVS_09995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVS_10005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVS_10015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVS_10025	COG1131	(ABC) transporter
HVS_10045	COG1595	DNA-templated transcription, initiation
HVS_10055	COG1122	ATPase activity
HVS_10075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVS_10080	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HVS_10090	COG0457	Tetratricopeptide repeat
HVS_10090	COG0463	Glycosyl transferase, family 2
HVS_10105	COG0740	serine-type endopeptidase activity
HVS_10140	COG4969	Belongs to the N-Me-Phe pilin family
HVS_10145	COG1459	type II secretion system
HVS_10155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVS_10160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVS_10170	COG0612	Peptidase, M16
HVS_10175	COG1185	polyribonucleotide nucleotidyltransferase activity
HVS_10180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HVS_10185	COG2848	UPF0210 protein
HVS_10190	COG3830	Belongs to the UPF0237 family
HVS_10210	COG4447	cellulose binding
HVS_10215	COG1191	sigma factor activity
HVS_10220	COG2176	DNA-directed DNA polymerase activity
HVS_10225	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVS_10260	COG1191	sigma factor activity
HVS_10270	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HVS_10275	COG1776	CheC inhibitor of MCP methylation
HVS_10285	COG0643	Histidine kinase
HVS_10285	COG2198	Histidine kinase
HVS_10290	COG2201	protein-glutamate methylesterase activity
HVS_10305	COG1419	protein localization to endoplasmic reticulum
HVS_10310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVS_10315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVS_10320	COG1684	flagellar biosynthetic protein fliR
HVS_10325	COG1987	bacterial-type flagellum assembly
HVS_10330	COG1338	Plays a role in the flagellum-specific transport system
HVS_10340	COG2201	protein-glutamate methylesterase activity
HVS_10345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVS_10345	COG1776	CheC inhibitor of MCP methylation
HVS_10350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVS_10360	COG1582	Flagellar protein (FlbD)
HVS_10375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVS_10395	COG1157	protein secretion by the type III secretion system
HVS_10405	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVS_10415	COG1677	Flagellar hook-basal body complex protein FliE
HVS_10420	COG1558	bacterial-type flagellum-dependent cell motility
HVS_10425	COG1815	bacterial-type flagellum-dependent cell motility
HVS_10430	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HVS_10435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVS_10440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HVS_10440	COG0758	DNA mediated transformation
HVS_10445	COG0606	chelatase, subunit chli
HVS_10455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HVS_10460	COG1873	PFAM PRC-barrel domain
HVS_10465	COG1191	sigma factor activity
HVS_10470	COG1191	sigma factor activity
HVS_10480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVS_10490	COG0849	cell division
HVS_10495	COG3856	small basic protein
HVS_10505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_10510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVS_10515	COG3442	glutamine amidotransferase
HVS_10530	COG1122	ATPase activity
HVS_10570	COG1136	(ABC) transporter
HVS_10580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_10585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HVS_10590	COG0772	Belongs to the SEDS family
HVS_10595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVS_10600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVS_10605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVS_10610	COG0768	penicillin binding
HVS_10620	COG0275	rRNA processing
HVS_10625	COG2001	Belongs to the MraZ family
HVS_10635	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HVS_10640	COG0612	Peptidase, M16
HVS_10645	COG0612	Peptidase, M16
HVS_10660	COG0196	riboflavin kinase activity
HVS_10665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HVS_10670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HVS_10675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HVS_10680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HVS_10690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HVS_10695	COG0195	Participates in both transcription termination and antitermination
HVS_10700	COG0779	Required for maturation of 30S ribosomal subunits
HVS_10715	COG0697	spore germination
HVS_10730	COG1361	Conserved repeat domain
HVS_10735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVS_10745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HVS_10770	COG0628	permease
HVS_10775	COG1193	negative regulation of DNA recombination
HVS_10785	COG2201	protein-glutamate methylesterase activity
HVS_10790	COG2205	protein histidine kinase activity
HVS_10800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVS_10805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HVS_10810	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HVS_10815	COG1160	GTP binding
HVS_10820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HVS_10835	COG3850	Histidine kinase
HVS_10835	COG5002	protein histidine kinase activity
HVS_10840	COG0745	RESPONSE REGULATOR receiver
HVS_10845	COG3458	cephalosporin-C deacetylase activity
HVS_10865	COG0824	Thioesterase
HVS_10870	COG0205	6-phosphofructokinase activity
HVS_10890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVS_10905	COG3314	Sporulation integral membrane protein YlbJ
HVS_10935	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVS_10935	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVS_10935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVS_10935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVS_10950	COG1136	(ABC) transporter
HVS_10955	COG0024	Methionine aminopeptidase
HVS_10960	COG3850	Histidine kinase
HVS_10960	COG5002	protein histidine kinase activity
HVS_10970	COG0318	PFAM AMP-dependent synthetase and ligase
HVS_10975	COG0656	L-ascorbic acid biosynthetic process
HVS_11010	COG2832	Protein of unknown function (DUF454)
HVS_11025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HVS_11030	COG0742	ribosomal rna small subunit methyltransferase
HVS_11035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVS_11040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HVS_11050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVS_11055	COG0297	glycogen (starch) synthase activity
HVS_11060	COG2199	diguanylate cyclase activity
HVS_11060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HVS_11070	COG5002	protein histidine kinase activity
HVS_11075	COG0745	RESPONSE REGULATOR receiver
HVS_11090	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVS_11100	COG0735	belongs to the Fur family
HVS_11105	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HVS_11110	COG3328	transposase activity
HVS_11130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HVS_11145	COG1323	Belongs to the UPF0348 family
HVS_11150	COG0840	transmembrane signaling receptor activity
HVS_11155	COG3464	Transposase
HVS_11165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HVS_11170	COG2273	Hydrolase Family 16
HVS_11170	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_11180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HVS_11195	COG3693	PFAM glycoside hydrolase, family 10
HVS_11210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVS_11210	COG0574	Belongs to the PEP-utilizing enzyme family
HVS_11215	COG0423	glycine-tRNA ligase activity
HVS_11220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVS_11225	COG1758	RNA polymerase activity
HVS_11230	COG2052	Domain of unknown function (DUF370)
HVS_11235	COG1561	YicC-like family, N-terminal region
HVS_11240	COG2201	protein-glutamate methylesterase activity
HVS_11245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVS_11250	COG2264	protein methyltransferase activity
HVS_11255	COG0484	heat shock protein binding
HVS_11260	COG0443	Heat shock 70 kDa protein
HVS_11265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HVS_11270	COG1420	regulation of RNA biosynthetic process
HVS_11275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVS_11280	COG0481	GTPase activity
HVS_11305	COG0681	Belongs to the peptidase S26 family
HVS_11310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HVS_11315	COG0124	histidyl-tRNA synthetase
HVS_11325	COG1490	D-aminoacyl-tRNA deacylase activity
HVS_11330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVS_11345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HVS_11345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVS_11350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVS_11355	COG0629	single-stranded DNA binding
HVS_11365	COG0493	'glutamate synthase
HVS_11365	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVS_11375	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HVS_11380	COG1691	(AIR) carboxylase
HVS_11395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVS_11410	COG0436	Aminotransferase
HVS_11415	COG1522	sequence-specific DNA binding
HVS_11425	COG3118	belongs to the thioredoxin family
HVS_11445	COG1595	DNA-templated transcription, initiation
HVS_11460	COG0285	dihydrofolate synthase activity
HVS_11465	COG0653	protein targeting
HVS_11480	COG4496	protein, YerC YecD
HVS_11485	COG3464	Transposase
HVS_11515	COG0166	Belongs to the GPI family
HVS_11525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVS_11525	COG0072	phenylalanine-tRNA ligase activity
HVS_11530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HVS_11535	COG2723	6-phospho-beta-galactosidase activity
HVS_11545	COG0393	Putative heavy-metal-binding
HVS_11555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVS_11555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HVS_11565	COG1074	ATP-dependent DNA helicase activity
HVS_11595	COG0840	transmembrane signaling receptor activity
HVS_11645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HVS_11650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HVS_11660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVS_11665	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVS_11665	COG2247	cell wall binding repeat
HVS_11675	COG2255	four-way junction helicase activity
HVS_11680	COG0632	four-way junction helicase activity
HVS_11685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HVS_11705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVS_11715	COG1534	Rna-binding protein
HVS_11720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HVS_11725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HVS_11735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HVS_11765	COG3906	Belongs to the UPF0473 family
HVS_11770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HVS_11775	COG0667	Aldo Keto reductase
HVS_11780	COG4472	Bacterial protein of unknown function (DUF965)
HVS_11785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HVS_11795	COG1683	Conserved Protein
HVS_11800	COG0557	exoribonuclease II activity
HVS_11815	COG0148	phosphopyruvate hydratase activity
HVS_11860	COG0714	Associated with various cellular activities
HVS_11920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_11950	COG4447	cellulose binding
HVS_11955	COG1191	sigma factor activity
HVS_11960	COG3693	PFAM glycoside hydrolase, family 10
HVS_11965	COG1649	PFAM Uncharacterised BCR, COG1649
HVS_11970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVS_11980	COG3464	Transposase
HVS_12015	COG1573	uracil-dna glycosylase
HVS_12020	COG1573	uracil-dna glycosylase
HVS_12025	COG0602	queuosine metabolic process
HVS_12030	COG0720	synthase
HVS_12035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HVS_12050	COG1988	membrane-bound metal-dependent
HVS_12055	COG1316	TRANSCRIPTIONal
HVS_12065	COG0463	Glycosyl transferase, family 2
HVS_12100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HVS_12130	COG0745	RESPONSE REGULATOR receiver
HVS_12135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HVS_12140	COG4565	transcriptional regulatory protein
HVS_12145	COG0116	Belongs to the methyltransferase superfamily
HVS_12150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVS_12155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVS_12160	COG1116	anion transmembrane transporter activity
HVS_12170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HVS_12175	COG0149	triose-phosphate isomerase activity
HVS_12180	COG0126	phosphoglycerate kinase activity
HVS_12210	COG0318	PFAM AMP-dependent synthetase and ligase
HVS_12215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_12220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVS_12225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVS_12240	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVS_12245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVS_12265	COG2172	sigma factor antagonist activity
HVS_12270	COG1366	Belongs to the anti-sigma-factor antagonist family
HVS_12280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVS_12285	COG1481	regulation of sporulation
HVS_12295	COG1660	Displays ATPase and GTPase activities
HVS_12300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVS_12305	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HVS_12325	COG2207	Transcriptional regulator
HVS_12325	COG4753	response regulator
HVS_12345	COG1187	pseudouridine synthase activity
HVS_12350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HVS_12350	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HVS_12355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HVS_12360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVS_12365	COG0840	transmembrane signaling receptor activity
HVS_12375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HVS_12390	COG0527	aspartate kinase activity
HVS_12395	COG0460	homoserine dehydrogenase
HVS_12400	COG4492	Belongs to the UPF0735 family
HVS_12410	COG3464	Transposase
HVS_12415	COG1472	Belongs to the glycosyl hydrolase 3 family
HVS_12420	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_12425	COG0402	S-adenosylhomocysteine deaminase activity
HVS_12435	COG1136	(ABC) transporter
HVS_12445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HVS_12480	COG1131	(ABC) transporter
HVS_12495	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HVS_12520	COG0395	ABC-type sugar transport system, permease component
HVS_12535	COG1924	4 iron, 4 sulfur cluster binding
HVS_12550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVS_12555	COG0191	fructose-bisphosphate aldolase activity
HVS_12560	COG0205	6-phosphofructokinase activity
HVS_12565	COG1882	Formate acetyltransferase
HVS_12590	COG5002	protein histidine kinase activity
HVS_12615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HVS_12625	COG0428	transporter
HVS_12630	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVS_12645	COG0662	Cupin 2, conserved barrel domain protein
HVS_12675	COG3949	Membrane
HVS_12685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HVS_12690	COG3464	Transposase
HVS_12705	COG1484	DNA-dependent DNA replication
HVS_12710	COG4584	PFAM Integrase catalytic
HVS_12715	COG4584	PFAM Integrase catalytic
HVS_12715	COG2390	Transcriptional regulator
HVS_12735	COG0488	(ABC) transporter
HVS_12750	COG1132	(ABC) transporter
HVS_12755	COG1132	(ABC) transporter
HVS_12785	COG0037	tRNA processing
HVS_12795	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HVS_12800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVS_12815	COG1408	metallophosphoesterase
HVS_12830	COG0542	response to heat
HVS_12835	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HVS_12840	COG0556	nucleotide-excision repair
HVS_12860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVS_12865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HVS_12870	COG0287	Prephenate dehydrogenase
HVS_12875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HVS_12880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HVS_12885	COG0488	(ABC) transporter
HVS_12890	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVS_12900	COG2094	Belongs to the DNA glycosylase MPG family
HVS_12915	COG0432	Pfam Uncharacterised protein family UPF0047
HVS_12930	COG4221	oxidoreductase activity
HVS_12950	COG0714	Associated with various cellular activities
HVS_12955	COG1668	transmembrane transport
HVS_12965	COG4152	abc transporter atp-binding protein
HVS_12980	COG0840	transmembrane signaling receptor activity
HVS_12990	COG2273	Hydrolase Family 16
HVS_13000	COG1361	Conserved repeat domain
HVS_13010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HVS_13015	COG2273	Hydrolase Family 16
HVS_13020	COG3291	Pkd domain containing protein
HVS_13025	COG2755	lipolytic protein G-D-S-L family
HVS_13025	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_13030	COG3693	PFAM glycoside hydrolase, family 10
HVS_13045	COG0613	PHP domain protein
HVS_13055	COG0741	lytic transglycosylase activity
HVS_13060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HVS_13065	COG1968	undecaprenyl-diphosphatase activity
HVS_13070	COG0470	DNA polymerase III
HVS_13070	COG1067	ATP-dependent peptidase activity
HVS_13095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HVS_13100	COG0740	serine-type endopeptidase activity
HVS_13105	COG0544	peptidyl-prolyl cis-trans isomerase activity
HVS_13115	COG0322	excinuclease ABC activity
HVS_13135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVS_13140	COG5662	AntiSigma factor
HVS_13145	COG1595	DNA-templated transcription, initiation
HVS_13150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HVS_13155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HVS_13160	COG0049	tRNA binding
HVS_13165	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HVS_13170	COG1358	cellular component organization or biogenesis
HVS_13175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HVS_13180	COG0085	RNA polymerase activity
HVS_13185	COG0222	ribosome binding
HVS_13190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HVS_13195	COG0081	regulation of translation
HVS_13200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HVS_13205	COG0250	Participates in transcription elongation, termination and antitermination
HVS_13220	COG0028	Belongs to the TPP enzyme family
HVS_13225	COG0129	dihydroxy-acid dehydratase activity
HVS_13240	COG3464	Transposase
HVS_13245	COG3949	Membrane
HVS_13265	COG1131	(ABC) transporter
HVS_13270	COG0793	Belongs to the peptidase S41A family
HVS_13285	COG1395	domain, Protein
HVS_13290	COG0705	Rhomboid family
HVS_13290	COG0457	Tetratricopeptide repeat
HVS_13295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVS_13300	COG3850	Histidine kinase
HVS_13300	COG5002	protein histidine kinase activity
HVS_13320	COG0840	transmembrane signaling receptor activity
HVS_13345	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVS_13430	COG0740	serine-type endopeptidase activity
HVS_13435	COG4695	Portal protein
HVS_13440	COG1802	Transcriptional regulator
HVS_13440	COG4626	Terminase
HVS_13535	COG1484	DNA-dependent DNA replication
HVS_13540	COG4584	PFAM Integrase catalytic
HVS_13605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVS_13635	COG0438	transferase activity, transferring glycosyl groups
HVS_13670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVS_13695	COG0514	ATP-dependent DNA helicase (RecQ)
HVS_13715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVS_13735	COG5632	N-Acetylmuramoyl-L-alanine amidase
HVS_13735	COG3409	Peptidoglycan-binding domain 1 protein
HVS_13815	COG3464	Transposase
HVS_13850	COG1353	crispr-associated protein
HVS_13890	COG2207	Transcriptional regulator
HVS_13890	COG3708	Transcriptional regulator
HVS_13930	COG1361	Conserved repeat domain
HVS_13935	COG3328	transposase activity
HVS_13940	COG1028	Short-chain dehydrogenase reductase Sdr
HVS_13945	COG0583	DNA-binding transcription factor activity
HVS_13965	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HVS_13990	COG0535	radical SAM domain protein
HVS_14010	COG4447	cellulose binding
HVS_14010	COG4733	cellulase activity
HVS_14015	COG4447	cellulose binding
HVS_14020	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVS_14075	COG0493	'glutamate synthase
HVS_14090	COG0697	spore germination
HVS_14100	COG2217	Heavy metal translocating P-type atpase
HVS_14110	COG0668	transmembrane transport
HVS_14120	COG0840	transmembrane signaling receptor activity
HVS_14125	COG1012	belongs to the aldehyde dehydrogenase family
HVS_14125	COG1454	alcohol dehydrogenase
HVS_14160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVS_14165	COG0601	transmembrane transport
HVS_14170	COG4166	transmembrane transport
HVS_14175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVS_14185	COG2755	lipolytic protein G-D-S-L family
HVS_14185	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_14195	COG0071	Belongs to the small heat shock protein (HSP20) family
HVS_14200	COG2244	polysaccharide biosynthetic process
HVS_14210	COG0297	glycogen (starch) synthase activity
HVS_14215	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HVS_14225	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVS_14230	COG0864	Transcriptional regulator
HVS_14240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVS_14245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVS_14245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVS_14270	COG0110	maltose O-acetyltransferase activity
HVS_14275	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HVS_14280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVS_14315	COG0714	Associated with various cellular activities
HVS_14330	COG2304	oxidoreductase activity
HVS_14350	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HVS_14370	COG1395	domain, Protein
HVS_14380	COG3546	catalase activity
HVS_14420	COG1151	hydroxylamine reductase activity
HVS_14430	COG1982	Orn Lys Arg decarboxylase major
HVS_14445	COG0504	CTP synthase activity
HVS_14450	COG3464	Transposase
HVS_14455	COG2340	Cysteine-rich secretory protein family
HVS_14460	COG0442	prolyl-tRNA aminoacylation
HVS_14475	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HVS_14490	COG4166	transmembrane transport
HVS_14495	COG4166	transmembrane transport
HVS_14505	COG0745	RESPONSE REGULATOR receiver
HVS_14535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HVS_14540	COG1278	Cold shock
HVS_14550	COG5444	nuclease activity
HVS_14565	COG0739	heme binding
HVS_14570	COG2177	Part of the ABC transporter FtsEX involved in
HVS_14575	COG2884	Cell division ATP-binding protein ftsE
HVS_14580	COG2508	Transcriptional regulator
HVS_14585	COG3842	ATPase activity
HVS_14590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVS_14595	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVS_14605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVS_14610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVS_14620	COG4585	Histidine kinase
HVS_14625	COG2197	response regulator
HVS_14685	COG3459	Glycosyltransferase 36 associated
HVS_14695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVS_14700	COG3959	Transketolase, thiamine diphosphate binding domain
HVS_14705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HVS_14730	COG4447	cellulose binding
HVS_14735	COG1607	acyl-coa hydrolase
HVS_14745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVS_14750	COG0681	Belongs to the peptidase S26 family
HVS_14770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVS_14780	COG1063	alcohol dehydrogenase
HVS_14790	COG0826	peptidase U32
HVS_14800	COG5297	Belongs to the glycosyl hydrolase family 6
HVS_14815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HVS_14820	COG3583	domain protein
HVS_14820	COG3584	3D domain protein
HVS_14830	COG0084	hydrolase, TatD family'
HVS_14835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVS_14835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVS_14840	COG0700	Nucleoside recognition
HVS_14845	COG2715	membrane protein required for spore maturation
HVS_14850	COG2002	toxin-antitoxin pair type II binding
HVS_14855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVS_14860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HVS_14870	COG1774	PSP1 C-terminal conserved region
HVS_14875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVS_14890	COG1982	Orn Lys Arg decarboxylase major
HVS_14900	COG0281	malic enzyme
HVS_14905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HVS_14915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVS_14915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVS_14925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVS_14930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVS_14935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVS_14940	COG0248	Ppx GppA phosphatase
HVS_14945	COG2382	esterase
HVS_14945	COG3507	Belongs to the glycosyl hydrolase 43 family
HVS_14945	COG3693	PFAM glycoside hydrolase, family 10
HVS_14950	COG2133	pyrroloquinoline quinone binding
HVS_14950	COG5183	chlorophyll binding
HVS_14955	COG1191	sigma factor activity
HVS_14960	COG3464	Transposase
HVS_14970	COG1496	oxidoreductase activity
HVS_15000	COG0302	gtp cyclohydrolase
HVS_15010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVS_15015	COG0473	3-isopropylmalate dehydrogenase activity
HVS_15020	COG1191	sigma factor activity
HVS_15040	COG2911	Protein conserved in bacteria
HVS_15040	COG3266	domain, Protein
HVS_15040	COG1361	Conserved repeat domain
HVS_15050	COG2207	Transcriptional regulator
HVS_15055	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HVS_15060	COG1073	alpha beta
HVS_15070	COG1516	flagellar protein fliS
HVS_15075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVS_15100	COG3344	reverse transcriptase
HVS_15135	COG3464	Transposase
HVS_15145	COG4974	Belongs to the 'phage' integrase family
HVS_15150	COG0732	type I restriction modification DNA specificity domain
HVS_15195	COG4191	Histidine kinase
HVS_15200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HVS_15210	COG1329	Transcriptional regulator
HVS_15215	COG0101	tRNA pseudouridine synthase activity
HVS_15220	COG1940	carbohydrate kinase activity
HVS_15225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HVS_15230	COG1122	ATPase activity
HVS_15235	COG2813	Specifically methylates the guanine in position
HVS_15240	COG1122	ATPase activity
HVS_15245	COG0203	ribosomal protein L17
HVS_15250	COG0202	RNA polymerase activity
HVS_15255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HVS_15260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HVS_15265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HVS_15270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HVS_15275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HVS_15290	COG0563	adenylate kinase activity
HVS_15295	COG0201	protein transport
HVS_15300	COG0200	Binds to the 23S rRNA
HVS_15305	COG1841	ribosomal large subunit assembly
HVS_15310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HVS_15315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HVS_15320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HVS_15325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HVS_15330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HVS_15335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HVS_15340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HVS_15345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HVS_15350	COG0255	Belongs to the universal ribosomal protein uL29 family
HVS_15355	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HVS_15360	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HVS_15365	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HVS_15370	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HVS_15375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HVS_15380	COG0089	rRNA binding
HVS_15385	COG0088	Forms part of the polypeptide exit tunnel
HVS_15390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HVS_15395	COG0051	transcription antitermination factor activity, RNA binding
HVS_15425	COG1191	sigma factor activity
HVS_15435	COG1366	Belongs to the anti-sigma-factor antagonist family
HVS_15440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVS_15445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVS_15450	COG3464	Transposase
HVS_15460	COG0516	GMP reductase activity
HVS_15460	COG0517	IMP dehydrogenase activity
HVS_15475	COG0459	protein refolding
HVS_15480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HVS_15495	COG0107	imidazoleglycerol-phosphate synthase activity
HVS_15500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HVS_15505	COG0131	Imidazoleglycerol-phosphate dehydratase
HVS_15510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HVS_15515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVS_15520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HVS_15525	COG0124	histidyl-tRNA synthetase
HVS_15530	COG0840	transmembrane signaling receptor activity
HVS_15530	COG5278	phosphoserine phosphatase activity
HVS_15535	COG0210	DNA helicase
HVS_15540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVS_15550	COG1714	RDD family
HVS_15555	COG0616	signal peptide processing
HVS_15560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVS_15565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HVS_15580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVS_15605	COG3464	Transposase
HVS_15615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVS_15620	COG4481	Protein conserved in bacteria
HVS_15635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVS_15635	COG0551	DNA topoisomerase type I activity
HVS_15645	COG2033	superoxide reductase activity
HVS_15650	COG3401	FG-GAP repeat protein
HVS_15655	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HVS_15660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVS_15665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HVS_15685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVS_15720	COG0561	phosphatase activity
HVS_15735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_15760	COG3546	catalase activity
HVS_15780	COG3546	catalase activity
HVS_15795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVS_15805	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HVS_15810	COG0698	ribose 5-phosphate isomerase
HVS_15820	COG0009	L-threonylcarbamoyladenylate synthase
HVS_15830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HVS_15850	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVS_15875	COG0386	Belongs to the glutathione peroxidase family
HVS_15880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVS_15890	COG2268	Band 7 protein
HVS_15920	COG0655	NAD(P)H dehydrogenase (quinone) activity
HVS_15925	COG2755	lipolytic protein G-D-S-L family
HVS_15925	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HVS_15935	COG0653	protein targeting
HVS_15940	COG1368	sulfuric ester hydrolase activity
HVS_15945	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVS_15960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVS_15970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVS_15980	COG0215	cysteine-tRNA ligase activity
HVS_15985	COG1045	serine acetyltransferase
HVS_15990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVS_15990	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HVS_16025	COG2155	Conserved Protein
HVS_16030	COG0217	transcriptional regulatory protein
HVS_16035	COG4191	Histidine kinase
HVS_16035	COG0745	RESPONSE REGULATOR receiver
HVS_16035	COG2205	protein histidine kinase activity
HVS_16045	COG1739	Uncharacterized protein family UPF0029
HVS_16065	COG3250	beta-galactosidase activity
HVS_16075	COG1609	Transcriptional regulator
HVS_16085	COG2385	sporulation resulting in formation of a cellular spore
HVS_16190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HVS_16195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVS_16200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HVS_16220	COG5002	protein histidine kinase activity
HVS_16245	COG0517	IMP dehydrogenase activity
HVS_16260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVS_16265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HVS_16385	COG0726	polysaccharide deacetylase
HVS_16390	COG0840	transmembrane signaling receptor activity
HVS_16395	COG2207	Transcriptional regulator
HVS_16405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVS_16410	COG0840	transmembrane signaling receptor activity
HVS_16415	COG1475	DNA binding
HVS_16420	COG0357	Ribosomal RNA small subunit methyltransferase G
HVS_16425	COG0445	tRNA wobble uridine modification
HVS_16430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HVS_16435	COG1847	R3H domain protein
HVS_16445	COG0594	ribonuclease P activity
HVS_16450	COG0230	Belongs to the bacterial ribosomal protein bL34 family