locus-tag	class	description
AD2_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AD2_00002	COG0592	DNA-directed DNA polymerase activity
AD2_00004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AD2_00006	COG0187	DNA topoisomerase II activity
AD2_00007	COG1192	Involved in chromosome partitioning
AD2_00008	COG1475	DNA binding
AD2_00011	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AD2_00012	COG2814	Major facilitator Superfamily
AD2_00014	COG2373	Large extracellular alpha-helical protein
AD2_00016	COG2720	vancomycin resistance protein
AD2_00020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AD2_00022	COG0674	pyruvate-flavodoxin oxidoreductase activity
AD2_00023	COG1013	pyruvate-flavodoxin oxidoreductase activity
AD2_00030	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AD2_00034	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AD2_00035	COG1802	Transcriptional regulator
AD2_00036	COG2608	mercury ion transmembrane transporter activity
AD2_00038	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AD2_00043	COG4717	serine-type aminopeptidase activity
AD2_00044	COG0791	NLP P60 protein
AD2_00045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AD2_00048	COG2959	enzyme of heme biosynthesis
AD2_00052	COG1078	dGTPase activity
AD2_00059	COG3872	metal-dependent enzyme
AD2_00060	COG2890	protein-(glutamine-N5) methyltransferase activity
AD2_00062	COG4656	Part of a membrane complex involved in electron transport
AD2_00063	COG4658	electron transport chain
AD2_00064	COG4659	FMN binding
AD2_00065	COG4660	Part of a membrane complex involved in electron transport
AD2_00066	COG4657	Part of a membrane complex involved in electron transport
AD2_00067	COG2878	Part of a membrane complex involved in electron transport
AD2_00073	COG1349	DNA-binding transcription factor activity
AD2_00074	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AD2_00075	COG3959	Transketolase, thiamine diphosphate binding domain
AD2_00076	COG3958	Transketolase
AD2_00077	COG1063	alcohol dehydrogenase
AD2_00078	COG1879	ABC-type sugar transport system periplasmic component
AD2_00079	COG1129	ABC transporter
AD2_00081	COG0406	alpha-ribazole phosphatase activity
AD2_00082	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AD2_00083	COG1164	Oligoendopeptidase f
AD2_00085	COG3693	PFAM glycoside hydrolase, family 10
AD2_00086	COG0590	tRNA wobble adenosine to inosine editing
AD2_00088	COG0662	Cupin 2, conserved barrel domain protein
AD2_00089	COG3584	3D domain protein
AD2_00090	COG1609	Transcriptional regulator
AD2_00095	COG0668	transmembrane transport
AD2_00097	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_00099	COG0590	tRNA wobble adenosine to inosine editing
AD2_00100	COG0028	Belongs to the TPP enzyme family
AD2_00101	COG0440	acetolactate synthase activity
AD2_00102	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AD2_00103	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AD2_00105	COG1191	sigma factor activity
AD2_00108	COG1959	2 iron, 2 sulfur cluster binding
AD2_00109	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AD2_00111	COG0181	hydroxymethylbilane synthase activity
AD2_00113	COG0113	porphobilinogen synthase activity
AD2_00114	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AD2_00115	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AD2_00116	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AD2_00117	COG4208	sulfate ABC transporter
AD2_00119	COG0175	sulfate reduction
AD2_00120	COG0175	sulfate reduction
AD2_00123	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AD2_00128	COG1595	DNA-templated transcription, initiation
AD2_00135	COG3534	alpha-L-arabinofuranosidase
AD2_00137	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_00139	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_00141	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_00144	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_00145	COG1216	Glycosyl transferase, family 2
AD2_00146	COG1088	dTDP-glucose 4,6-dehydratase activity
AD2_00148	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AD2_00152	COG3328	transposase activity
AD2_00154	COG1032	radical SAM domain protein
AD2_00162	COG1116	anion transmembrane transporter activity
AD2_00163	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_00164	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AD2_00166	COG2954	triphosphatase activity
AD2_00170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AD2_00171	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AD2_00172	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AD2_00174	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AD2_00174	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AD2_00177	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AD2_00179	COG3693	PFAM glycoside hydrolase, family 10
AD2_00182	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AD2_00183	COG0428	transporter
AD2_00184	COG0009	L-threonylcarbamoyladenylate synthase
AD2_00186	COG0698	ribose 5-phosphate isomerase
AD2_00187	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AD2_00188	COG2131	deaminase
AD2_00189	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AD2_00190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AD2_00191	COG0356	it plays a direct role in the translocation of protons across the membrane
AD2_00192	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AD2_00193	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AD2_00194	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AD2_00195	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AD2_00196	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AD2_00197	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AD2_00198	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AD2_00202	COG2911	Protein conserved in bacteria
AD2_00202	COG3266	domain, Protein
AD2_00202	COG1361	Conserved repeat domain
AD2_00204	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_00205	COG2385	sporulation resulting in formation of a cellular spore
AD2_00207	COG1609	Transcriptional regulator
AD2_00209	COG4786	Flagellar basal body rod
AD2_00213	COG0577	efflux transmembrane transporter activity
AD2_00213	COG1136	(ABC) transporter
AD2_00214	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AD2_00215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AD2_00216	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AD2_00217	COG2088	sporulation resulting in formation of a cellular spore
AD2_00218	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AD2_00220	COG0193	aminoacyl-tRNA hydrolase activity
AD2_00221	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AD2_00222	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AD2_00224	COG1917	Cupin 2, conserved barrel domain protein
AD2_00224	COG2207	Transcriptional regulator
AD2_00225	COG0259	pyridoxamine-phosphate oxidase activity
AD2_00226	COG0728	peptidoglycan biosynthetic process
AD2_00230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AD2_00231	COG2089	acid synthase
AD2_00233	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AD2_00234	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AD2_00235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AD2_00237	COG1181	Belongs to the D-alanine--D-alanine ligase family
AD2_00238	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AD2_00244	COG4464	protein tyrosine phosphatase activity
AD2_00245	COG2002	toxin-antitoxin pair type II binding
AD2_00246	COG3956	TIGRFAM MazG family protein
AD2_00248	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AD2_00252	COG1098	S1 RNA binding domain
AD2_00254	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AD2_00271	COG3852	Histidine kinase
AD2_00274	COG0793	Belongs to the peptidase S41A family
AD2_00280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AD2_00281	COG0849	cell division
AD2_00282	COG1607	acyl-coa hydrolase
AD2_00283	COG2244	polysaccharide biosynthetic process
AD2_00285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AD2_00287	COG0110	maltose O-acetyltransferase activity
AD2_00292	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AD2_00292	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AD2_00293	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AD2_00294	COG0864	Transcriptional regulator
AD2_00295	COG2337	Toxic component of a toxin-antitoxin (TA) module
AD2_00298	COG0438	transferase activity, transferring glycosyl groups
AD2_00299	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AD2_00300	COG3959	Transketolase, thiamine diphosphate binding domain
AD2_00301	COG3958	Transketolase
AD2_00302	COG1131	(ABC) transporter
AD2_00306	COG3949	Membrane
AD2_00309	COG0129	dihydroxy-acid dehydratase activity
AD2_00310	COG0028	Belongs to the TPP enzyme family
AD2_00313	COG0250	Participates in transcription elongation, termination and antitermination
AD2_00314	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AD2_00315	COG0081	regulation of translation
AD2_00316	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AD2_00318	COG0085	RNA polymerase activity
AD2_00319	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AD2_00320	COG1358	cellular component organization or biogenesis
AD2_00321	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AD2_00322	COG0049	tRNA binding
AD2_00323	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AD2_00324	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AD2_00328	COG2720	vancomycin resistance protein
AD2_00330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AD2_00331	COG0322	excinuclease ABC activity
AD2_00333	COG0544	peptidyl-prolyl cis-trans isomerase activity
AD2_00334	COG0740	serine-type endopeptidase activity
AD2_00335	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AD2_00336	COG0470	DNA polymerase III
AD2_00336	COG1067	ATP-dependent peptidase activity
AD2_00337	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AD2_00338	COG0741	lytic transglycosylase activity
AD2_00341	COG0613	PHP domain protein
AD2_00342	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AD2_00346	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AD2_00350	COG3263	regulation of cellular component size
AD2_00352	COG2207	Transcriptional regulator
AD2_00352	COG3708	Transcriptional regulator
AD2_00353	COG4447	cellulose binding
AD2_00353	COG4733	cellulase activity
AD2_00354	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_00361	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AD2_00362	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AD2_00364	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AD2_00374	COG1361	Conserved repeat domain
AD2_00374	COG2911	Protein conserved in bacteria
AD2_00374	COG3266	domain, Protein
AD2_00376	COG5012	cobalamin binding
AD2_00377	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AD2_00382	COG1116	anion transmembrane transporter activity
AD2_00383	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_00384	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AD2_00385	COG0436	Aminotransferase
AD2_00386	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AD2_00388	COG0674	pyruvate-flavodoxin oxidoreductase activity
AD2_00389	COG1013	pyruvate-flavodoxin oxidoreductase activity
AD2_00391	COG0251	oxidation-reduction process
AD2_00392	COG0626	cystathionine gamma-synthase activity
AD2_00393	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AD2_00394	COG1151	hydroxylamine reductase activity
AD2_00396	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_00397	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AD2_00399	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_00400	COG1609	Transcriptional regulator
AD2_00403	COG4124	Belongs to the glycosyl hydrolase 26 family
AD2_00404	COG4733	cellulase activity
AD2_00404	COG4447	cellulose binding
AD2_00406	COG2205	protein histidine kinase activity
AD2_00408	COG0835	chemotaxis
AD2_00409	COG2198	Histidine kinase
AD2_00409	COG0784	Response regulator, receiver
AD2_00409	COG0643	Histidine kinase
AD2_00411	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_00412	COG2201	protein-glutamate methylesterase activity
AD2_00414	COG1253	flavin adenine dinucleotide binding
AD2_00416	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_00418	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AD2_00424	COG0124	histidyl-tRNA synthetase
AD2_00425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AD2_00426	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AD2_00427	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AD2_00428	COG0131	Imidazoleglycerol-phosphate dehydratase
AD2_00429	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AD2_00430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AD2_00431	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AD2_00432	COG0107	imidazoleglycerol-phosphate synthase activity
AD2_00435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AD2_00436	COG0459	protein refolding
AD2_00439	COG3858	chitin binding
AD2_00441	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AD2_00442	COG1366	Belongs to the anti-sigma-factor antagonist family
AD2_00444	COG1191	sigma factor activity
AD2_00449	COG0051	transcription antitermination factor activity, RNA binding
AD2_00450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AD2_00451	COG0088	Forms part of the polypeptide exit tunnel
AD2_00452	COG0089	rRNA binding
AD2_00453	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AD2_00454	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AD2_00455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AD2_00456	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AD2_00457	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AD2_00458	COG0255	Belongs to the universal ribosomal protein uL29 family
AD2_00459	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AD2_00460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AD2_00461	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AD2_00462	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AD2_00463	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AD2_00464	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AD2_00465	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AD2_00466	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AD2_00467	COG1841	ribosomal large subunit assembly
AD2_00468	COG0200	Binds to the 23S rRNA
AD2_00469	COG0201	protein transport
AD2_00470	COG0563	adenylate kinase activity
AD2_00473	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AD2_00474	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AD2_00475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AD2_00476	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AD2_00477	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AD2_00478	COG0202	RNA polymerase activity
AD2_00479	COG0203	ribosomal protein L17
AD2_00480	COG1122	ATPase activity
AD2_00481	COG2813	Specifically methylates the guanine in position
AD2_00490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AD2_00491	COG1122	ATPase activity
AD2_00492	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AD2_00493	COG1940	carbohydrate kinase activity
AD2_00494	COG0101	tRNA pseudouridine synthase activity
AD2_00495	COG1329	Transcriptional regulator
AD2_00496	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AD2_00497	COG4555	ABC transporter
AD2_00498	COG1668	transmembrane transport
AD2_00499	COG4191	Histidine kinase
AD2_00499	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AD2_00500	COG3290	protein histidine kinase activity
AD2_00501	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AD2_00502	COG0442	prolyl-tRNA aminoacylation
AD2_00503	COG2340	Cysteine-rich secretory protein family
AD2_00504	COG2273	Hydrolase Family 16
AD2_00505	COG3250	beta-galactosidase activity
AD2_00517	COG4166	transmembrane transport
AD2_00518	COG4608	Belongs to the ABC transporter superfamily
AD2_00519	COG0444	Belongs to the ABC transporter superfamily
AD2_00520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AD2_00521	COG0601	transmembrane transport
AD2_00526	COG1725	Transcriptional regulator
AD2_00527	COG1131	(ABC) transporter
AD2_00531	COG1489	DNA binding
AD2_00532	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AD2_00533	COG1191	sigma factor activity
AD2_00540	COG0840	transmembrane signaling receptor activity
AD2_00541	COG1131	(ABC) transporter
AD2_00549	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AD2_00555	COG0693	protein deglycase activity
AD2_00557	COG1132	(ABC) transporter
AD2_00559	COG0306	phosphate transporter
AD2_00563	COG1388	LysM domain
AD2_00564	COG1376	ErfK ybiS ycfS ynhG family protein
AD2_00570	COG5520	Belongs to the glycosyl hydrolase 30 family
AD2_00572	COG0409	Hydrogenase expression formation protein
AD2_00574	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AD2_00578	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AD2_00578	COG3261	NADH dehydrogenase
AD2_00580	COG3260	NADH ubiquinone oxidoreductase 20
AD2_00582	COG2111	Na H antiporter
AD2_00582	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AD2_00584	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AD2_00585	COG0372	Belongs to the citrate synthase family
AD2_00586	COG0076	glutamate decarboxylase activity
AD2_00587	COG0835	chemotaxis
AD2_00588	COG0840	transmembrane signaling receptor activity
AD2_00593	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AD2_00594	COG0840	transmembrane signaling receptor activity
AD2_00601	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AD2_00605	COG0768	penicillin binding
AD2_00606	COG2003	Belongs to the UPF0758 family
AD2_00609	COG3328	transposase activity
AD2_00618	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AD2_00621	COG3458	cephalosporin-C deacetylase activity
AD2_00626	COG1131	(ABC) transporter
AD2_00628	COG5002	protein histidine kinase activity
AD2_00629	COG0745	RESPONSE REGULATOR receiver
AD2_00633	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AD2_00634	COG0561	phosphatase activity
AD2_00635	COG2304	oxidoreductase activity
AD2_00637	COG2911	Protein conserved in bacteria
AD2_00638	COG3266	domain, Protein
AD2_00638	COG2911	Protein conserved in bacteria
AD2_00638	COG1361	Conserved repeat domain
AD2_00639	COG1361	Conserved repeat domain
AD2_00640	COG1361	Conserved repeat domain
AD2_00644	COG0116	Belongs to the methyltransferase superfamily
AD2_00646	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AD2_00650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AD2_00653	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AD2_00655	COG0463	Glycosyl transferase, family 2
AD2_00658	COG0463	Glycosyl transferase, family 2
AD2_00660	COG1216	Glycosyl transferase, family 2
AD2_00661	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AD2_00662	COG0436	Aminotransferase
AD2_00663	COG1316	TRANSCRIPTIONal
AD2_00666	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AD2_00667	COG0720	synthase
AD2_00668	COG0602	queuosine metabolic process
AD2_00669	COG1573	uracil-dna glycosylase
AD2_00670	COG1573	uracil-dna glycosylase
AD2_00673	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AD2_00677	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
AD2_00678	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AD2_00681	COG1482	cell wall glycoprotein biosynthetic process
AD2_00683	COG2703	oxygen carrier activity
AD2_00684	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AD2_00684	COG1773	rubredoxin
AD2_00687	COG1361	Conserved repeat domain
AD2_00689	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_00691	COG1051	belongs to the nudix hydrolase family
AD2_00691	COG1056	cytidyltransferase-related domain
AD2_00694	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AD2_00697	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_00698	COG2267	carboxylic ester hydrolase activity
AD2_00701	COG1404	Belongs to the peptidase S8 family
AD2_00705	COG2755	lipolytic protein G-D-S-L family
AD2_00705	COG3401	FG-GAP repeat protein
AD2_00708	COG2207	Transcriptional regulator
AD2_00708	COG3708	Transcriptional regulator
AD2_00711	COG1132	(ABC) transporter
AD2_00712	COG1132	(ABC) transporter
AD2_00713	COG2195	Cleaves the N-terminal amino acid of tripeptides
AD2_00716	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AD2_00720	COG0840	transmembrane signaling receptor activity
AD2_00721	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AD2_00722	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AD2_00723	COG1802	Transcriptional regulator
AD2_00724	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AD2_00724	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AD2_00725	COG1187	pseudouridine synthase activity
AD2_00730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AD2_00731	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AD2_00732	COG1597	lipid kinase activity
AD2_00734	COG1136	(ABC) transporter
AD2_00736	COG1136	(ABC) transporter
AD2_00736	COG0577	efflux transmembrane transporter activity
AD2_00739	COG2323	membrane
AD2_00743	COG1686	Belongs to the peptidase S11 family
AD2_00745	COG0569	domain protein
AD2_00752	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AD2_00761	COG0628	permease
AD2_00762	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AD2_00780	COG3328	transposase activity
AD2_00797	COG3328	transposase activity
AD2_00802	COG3328	transposase activity
AD2_00803	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AD2_00803	COG0723	plastoquinol--plastocyanin reductase activity
AD2_00807	COG1126	abc transporter atp-binding protein
AD2_00816	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_00824	COG1595	DNA-templated transcription, initiation
AD2_00828	COG1028	Short-chain dehydrogenase reductase Sdr
AD2_00835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AD2_00836	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AD2_00838	COG0628	permease
AD2_00841	COG1714	RDD family
AD2_00842	COG0616	signal peptide processing
AD2_00843	COG1971	Probably functions as a manganese efflux pump
AD2_00846	COG1131	(ABC) transporter
AD2_00849	COG0133	tryptophan synthase activity
AD2_00850	COG0159	tryptophan synthase activity
AD2_00851	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AD2_00852	COG5002	protein histidine kinase activity
AD2_00853	COG0745	RESPONSE REGULATOR receiver
AD2_00856	COG5337	Spore coat protein CotH
AD2_00857	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AD2_00859	COG1321	iron dependent repressor
AD2_00863	COG4447	cellulose binding
AD2_00864	COG1442	glycosyl transferase family 8
AD2_00865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AD2_00866	COG0745	RESPONSE REGULATOR receiver
AD2_00867	COG5002	protein histidine kinase activity
AD2_00868	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AD2_00869	COG2267	carboxylic ester hydrolase activity
AD2_00870	COG0617	tRNA 3'-terminal CCA addition
AD2_00871	COG4496	protein, YerC YecD
AD2_00874	COG0653	protein targeting
AD2_00875	COG0285	dihydrofolate synthase activity
AD2_00877	COG1752	Esterase of the alpha-beta hydrolase superfamily
AD2_00879	COG2201	protein-glutamate methylesterase activity
AD2_00880	COG0673	inositol 2-dehydrogenase activity
AD2_00881	COG2199	diguanylate cyclase activity
AD2_00881	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_00882	COG4492	Belongs to the UPF0735 family
AD2_00883	COG0460	homoserine dehydrogenase
AD2_00884	COG0527	aspartate kinase activity
AD2_00894	COG0537	adenosine 5'-monophosphoramidase activity
AD2_00895	COG1361	Conserved repeat domain
AD2_00897	COG4464	protein tyrosine phosphatase activity
AD2_00901	COG0489	protein tyrosine kinase activity
AD2_00909	COG1216	Glycosyl transferase, family 2
AD2_00912	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AD2_00914	COG0629	single-stranded DNA binding
AD2_00915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AD2_00916	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AD2_00918	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AD2_00918	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AD2_00919	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AD2_00920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AD2_00921	COG1490	D-aminoacyl-tRNA deacylase activity
AD2_00922	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AD2_00923	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AD2_00933	COG0124	histidyl-tRNA synthetase
AD2_00934	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AD2_00940	COG0481	GTPase activity
AD2_00941	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AD2_00942	COG1420	regulation of RNA biosynthetic process
AD2_00943	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AD2_00944	COG0443	Heat shock 70 kDa protein
AD2_00945	COG0484	heat shock protein binding
AD2_00946	COG2264	protein methyltransferase activity
AD2_00947	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AD2_00948	COG2201	protein-glutamate methylesterase activity
AD2_00950	COG1561	YicC-like family, N-terminal region
AD2_00951	COG2052	Domain of unknown function (DUF370)
AD2_00952	COG0194	GDP metabolic process
AD2_00953	COG1758	RNA polymerase activity
AD2_00954	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AD2_00955	COG0423	glycine-tRNA ligase activity
AD2_00956	COG3290	protein histidine kinase activity
AD2_00959	COG0535	radical SAM domain protein
AD2_00960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AD2_00960	COG0574	Belongs to the PEP-utilizing enzyme family
AD2_00961	COG3693	PFAM glycoside hydrolase, family 10
AD2_00963	COG0662	Cupin 2, conserved barrel domain protein
AD2_00964	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AD2_00966	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AD2_00967	COG1323	Belongs to the UPF0348 family
AD2_00971	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AD2_00973	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AD2_00977	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AD2_00981	COG0745	RESPONSE REGULATOR receiver
AD2_00982	COG3850	Histidine kinase
AD2_00982	COG5002	protein histidine kinase activity
AD2_00983	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_00984	COG2199	diguanylate cyclase activity
AD2_00984	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_00985	COG0297	glycogen (starch) synthase activity
AD2_00986	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AD2_00989	COG2261	transglycosylase associated protein
AD2_00990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AD2_00991	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AD2_00992	COG0742	ribosomal rna small subunit methyltransferase
AD2_00993	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AD2_00995	COG3314	Sporulation integral membrane protein YlbJ
AD2_00996	COG2755	lipolytic protein G-D-S-L family
AD2_00997	COG1191	sigma factor activity
AD2_00998	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_01002	COG2197	response regulator
AD2_01003	COG0840	transmembrane signaling receptor activity
AD2_01004	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AD2_01008	COG0205	6-phosphofructokinase activity
AD2_01013	COG1472	Belongs to the glycosyl hydrolase 3 family
AD2_01018	COG2252	PERMEase
AD2_01019	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AD2_01020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AD2_01021	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AD2_01022	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AD2_01023	COG0138	bifunctional purine biosynthesis protein purh
AD2_01024	COG0151	Belongs to the GarS family
AD2_01025	COG1216	Glycosyl transferase, family 2
AD2_01027	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AD2_01028	COG1713	HD superfamily hydrolase involved in NAD metabolism
AD2_01030	COG0799	negative regulation of ribosome biogenesis
AD2_01031	COG0495	leucyl-tRNA aminoacylation
AD2_01033	COG0840	transmembrane signaling receptor activity
AD2_01035	COG1022	Amp-dependent synthetase and ligase
AD2_01036	COG1686	Belongs to the peptidase S11 family
AD2_01037	COG1555	photosystem II stabilization
AD2_01037	COG1596	polysaccharide export
AD2_01040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AD2_01042	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AD2_01043	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AD2_01044	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AD2_01045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AD2_01046	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AD2_01047	COG3459	Glycosyltransferase 36 associated
AD2_01050	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AD2_01051	COG0542	response to heat
AD2_01052	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AD2_01053	COG0730	response to heat
AD2_01057	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AD2_01063	COG2766	serine protein kinase
AD2_01064	COG2718	Belongs to the UPF0229 family
AD2_01065	COG2719	SpoVR family
AD2_01068	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AD2_01069	COG0402	S-adenosylhomocysteine deaminase activity
AD2_01077	COG3328	transposase activity
AD2_01079	COG0546	phosphoglycolate phosphatase activity
AD2_01081	COG4555	ABC transporter
AD2_01084	COG0657	acetylesterase activity
AD2_01087	COG0714	Associated with various cellular activities
AD2_01089	COG1305	Transglutaminase-like
AD2_01093	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AD2_01094	COG1406	Chemotaxis phosphatase CheX
AD2_01101	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AD2_01104	COG3885	ferrous iron binding
AD2_01104	COG2078	PFAM AMMECR1 domain protein
AD2_01106	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AD2_01108	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AD2_01109	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AD2_01110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AD2_01111	COG0640	Transcriptional regulator
AD2_01112	COG0798	PFAM Bile acid sodium symporter
AD2_01118	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AD2_01120	COG1459	type II secretion system
AD2_01128	COG0740	serine-type endopeptidase activity
AD2_01130	COG1674	ftsk spoiiie
AD2_01132	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AD2_01134	COG1418	mRNA catabolic process
AD2_01135	COG1692	metallophosphoesterase
AD2_01136	COG2359	stage V sporulation protein S
AD2_01140	COG0438	transferase activity, transferring glycosyl groups
AD2_01142	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AD2_01146	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AD2_01154	COG1702	phosphate starvation-inducible protein PhoH
AD2_01155	COG1480	7TM receptor with intracellular HD hydrolase
AD2_01156	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AD2_01157	COG0295	cytidine deaminase activity
AD2_01158	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AD2_01160	COG1381	Involved in DNA repair and RecF pathway recombination
AD2_01162	COG1104	cysteine desulfurase activity
AD2_01163	COG0301	tRNA thio-modification
AD2_01164	COG2720	vancomycin resistance protein
AD2_01168	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AD2_01169	COG1983	PspC domain protein
AD2_01170	COG1305	Transglutaminase-like
AD2_01172	COG0714	Associated with various cellular activities
AD2_01173	COG0039	L-malate dehydrogenase activity
AD2_01174	COG1058	Belongs to the CinA family
AD2_01174	COG1546	Belongs to the CinA family
AD2_01175	COG0728	peptidoglycan biosynthetic process
AD2_01176	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AD2_01178	COG0705	Rhomboid family
AD2_01178	COG0457	Tetratricopeptide repeat
AD2_01186	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AD2_01187	COG1466	dna polymerase III delta subunit
AD2_01188	COG0268	Binds directly to 16S ribosomal RNA
AD2_01192	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AD2_01195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AD2_01196	COG0154	amidase activity
AD2_01197	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AD2_01199	COG0280	phosphate acetyltransferase
AD2_01200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AD2_01202	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AD2_01204	COG1160	GTP binding
AD2_01206	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AD2_01207	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AD2_01209	COG1175	transmembrane transport
AD2_01210	COG0395	ABC-type sugar transport system, permease component
AD2_01211	COG2247	cell wall binding repeat
AD2_01211	COG0860	N-Acetylmuramoyl-L-alanine amidase
AD2_01214	COG1193	negative regulation of DNA recombination
AD2_01215	COG0628	permease
AD2_01217	COG0768	penicillin binding
AD2_01218	COG0826	peptidase U32
AD2_01219	COG4122	O-methyltransferase activity
AD2_01220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AD2_01221	COG1217	gtp-binding protein TYPA
AD2_01222	COG0052	Belongs to the universal ribosomal protein uS2 family
AD2_01223	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AD2_01224	COG0528	UMP kinase activity
AD2_01225	COG0233	cytoplasmic translational termination
AD2_01227	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AD2_01228	COG0575	Belongs to the CDS family
AD2_01229	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AD2_01231	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AD2_01234	COG0779	Required for maturation of 30S ribosomal subunits
AD2_01235	COG0195	Participates in both transcription termination and antitermination
AD2_01236	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AD2_01238	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AD2_01239	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AD2_01240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AD2_01241	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AD2_01242	COG0196	riboflavin kinase activity
AD2_01244	COG0612	Peptidase, M16
AD2_01245	COG0612	Peptidase, M16
AD2_01246	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AD2_01248	COG0772	Belongs to the SEDS family
AD2_01249	COG2001	Belongs to the MraZ family
AD2_01250	COG0275	rRNA processing
AD2_01252	COG0768	penicillin binding
AD2_01253	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AD2_01254	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AD2_01255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AD2_01256	COG0772	Belongs to the SEDS family
AD2_01257	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AD2_01258	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_01261	COG3328	transposase activity
AD2_01265	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AD2_01267	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AD2_01268	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AD2_01269	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AD2_01270	COG2247	cell wall binding repeat
AD2_01270	COG2385	sporulation resulting in formation of a cellular spore
AD2_01271	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AD2_01272	COG0343	queuine tRNA-ribosyltransferase activity
AD2_01273	COG1862	Preprotein translocase
AD2_01276	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AD2_01278	COG0540	Belongs to the ATCase OTCase family
AD2_01279	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AD2_01282	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AD2_01283	COG0543	2 iron, 2 sulfur cluster binding
AD2_01284	COG0167	dihydroorotate dehydrogenase activity
AD2_01285	COG0588	phosphoglycerate mutase activity
AD2_01289	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AD2_01290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AD2_01293	COG2030	dehydratase
AD2_01294	COG0416	fatty acid biosynthetic process
AD2_01295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AD2_01296	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AD2_01297	COG1028	Short-chain dehydrogenase reductase Sdr
AD2_01298	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AD2_01299	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AD2_01300	COG0571	ribonuclease III activity
AD2_01302	COG2359	stage V sporulation protein S
AD2_01305	COG0552	protein localization to endoplasmic reticulum
AD2_01309	COG1748	Saccharopine dehydrogenase
AD2_01316	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AD2_01321	COG1496	oxidoreductase activity
AD2_01323	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AD2_01324	COG0564	pseudouridine synthase activity
AD2_01326	COG1418	mRNA catabolic process
AD2_01327	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AD2_01328	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AD2_01329	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AD2_01330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AD2_01331	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AD2_01334	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AD2_01336	COG0358	DNA primase activity
AD2_01337	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AD2_01340	COG2384	SAM-dependent methyltransferase
AD2_01341	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AD2_01342	COG3437	response regulator, receiver
AD2_01343	COG1595	DNA-templated transcription, initiation
AD2_01347	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AD2_01347	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AD2_01348	COG0237	dephospho-CoA kinase activity
AD2_01351	COG0697	spore germination
AD2_01352	COG3706	GGDEF domain
AD2_01353	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AD2_01354	COG0835	chemotaxis
AD2_01355	COG0012	GTP binding
AD2_01358	COG0512	Glutamine amidotransferase of anthranilate synthase
AD2_01358	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AD2_01359	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AD2_01360	COG0134	indole-3-glycerol-phosphate synthase activity
AD2_01361	COG0135	phosphoribosylanthranilate isomerase activity
AD2_01372	COG1316	TRANSCRIPTIONal
AD2_01373	COG1592	Rubrerythrin
AD2_01375	COG4864	UPF0365 protein
AD2_01376	COG1030	water channel activity
AD2_01377	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AD2_01378	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AD2_01379	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AD2_01380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AD2_01381	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AD2_01383	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AD2_01384	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AD2_01385	COG0006	proline dipeptidase activity
AD2_01386	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AD2_01389	COG3854	ATPases associated with a variety of cellular activities
AD2_01397	COG1302	Protein conserved in bacteria
AD2_01400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AD2_01401	COG1570	exodeoxyribonuclease VII activity
AD2_01402	COG1722	exodeoxyribonuclease VII activity
AD2_01404	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AD2_01406	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AD2_01407	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AD2_01409	COG3291	Pkd domain containing protein
AD2_01414	COG1131	(ABC) transporter
AD2_01416	COG3706	GGDEF domain
AD2_01417	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AD2_01418	COG1438	arginine binding
AD2_01419	COG0497	DNA recombination
AD2_01420	COG0750	zinc metalloprotease
AD2_01421	COG0745	RESPONSE REGULATOR receiver
AD2_01422	COG2201	protein-glutamate methylesterase activity
AD2_01423	COG0643	Histidine kinase
AD2_01423	COG2198	Histidine kinase
AD2_01424	COG0835	chemotaxis
AD2_01426	COG2201	protein-glutamate methylesterase activity
AD2_01428	COG0745	RESPONSE REGULATOR receiver
AD2_01430	COG0564	pseudouridine synthase activity
AD2_01433	COG3328	transposase activity
AD2_01434	COG5002	protein histidine kinase activity
AD2_01435	COG0745	RESPONSE REGULATOR receiver
AD2_01437	COG2755	lipolytic protein G-D-S-L family
AD2_01437	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_01438	COG0366	Alpha amylase catalytic
AD2_01439	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AD2_01441	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AD2_01442	COG1799	cell septum assembly
AD2_01444	COG2302	S4 RNA-binding domain
AD2_01445	COG3599	regulation of cell shape
AD2_01447	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AD2_01450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AD2_01452	COG0840	transmembrane signaling receptor activity
AD2_01454	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AD2_01455	COG2340	Cysteine-rich secretory protein family
AD2_01457	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AD2_01458	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AD2_01459	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AD2_01460	COG1923	regulation of RNA biosynthetic process
AD2_01461	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AD2_01463	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AD2_01464	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AD2_01465	COG0228	four-way junction DNA binding
AD2_01466	COG1837	Belongs to the UPF0109 family
AD2_01467	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AD2_01468	COG0336	Belongs to the RNA methyltransferase TrmD family
AD2_01469	COG0335	large ribosomal subunit rRNA binding
AD2_01473	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AD2_01476	COG0792	nuclease activity
AD2_01477	COG2003	Belongs to the UPF0758 family
AD2_01484	COG3842	ATPase activity
AD2_01485	COG1176	ABC-type spermidine putrescine transport system, permease component I
AD2_01489	COG4733	cellulase activity
AD2_01490	COG0793	Belongs to the peptidase S41A family
AD2_01490	COG3409	Peptidoglycan-binding domain 1 protein
AD2_01491	COG0534	Mate efflux family protein
AD2_01493	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AD2_01494	COG2188	Transcriptional regulator
AD2_01500	COG2911	Protein conserved in bacteria
AD2_01500	COG1361	Conserved repeat domain
AD2_01500	COG3266	domain, Protein
AD2_01501	COG2911	Protein conserved in bacteria
AD2_01501	COG1361	Conserved repeat domain
AD2_01501	COG3266	domain, Protein
AD2_01504	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AD2_01507	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_01508	COG4974	Belongs to the 'phage' integrase family
AD2_01510	COG1362	aminopeptidase activity
AD2_01511	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_01511	COG2199	diguanylate cyclase activity
AD2_01512	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AD2_01513	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AD2_01514	COG0482	sulfurtransferase activity
AD2_01515	COG0822	iron-sulfur transferase activity
AD2_01517	COG1959	2 iron, 2 sulfur cluster binding
AD2_01520	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_01521	COG0105	UTP biosynthetic process
AD2_01522	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AD2_01523	COG0539	negative regulation of cytoplasmic translation
AD2_01523	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AD2_01524	COG0204	Acyl-transferase
AD2_01529	COG2081	HI0933 family
AD2_01530	COG0406	alpha-ribazole phosphatase activity
AD2_01531	COG1737	Transcriptional regulator
AD2_01537	COG0511	ligase activity, forming carbon-carbon bonds
AD2_01539	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AD2_01541	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AD2_01542	COG0010	Belongs to the arginase family
AD2_01543	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AD2_01544	COG1187	pseudouridine synthase activity
AD2_01545	COG3874	Sporulation protein YtfJ
AD2_01548	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AD2_01549	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AD2_01550	COG0180	Tryptophanyl-tRNA synthetase
AD2_01551	COG1994	Peptidase M50
AD2_01552	COG0617	tRNA 3'-terminal CCA addition
AD2_01552	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AD2_01552	COG3620	sequence-specific DNA binding
AD2_01555	COG0517	IMP dehydrogenase activity
AD2_01555	COG0516	GMP reductase activity
AD2_01557	COG1686	Belongs to the peptidase S11 family
AD2_01559	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AD2_01560	COG4974	Belongs to the 'phage' integrase family
AD2_01561	COG1300	Membrane
AD2_01563	COG0328	RNA-DNA hybrid ribonuclease activity
AD2_01564	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AD2_01569	COG0697	spore germination
AD2_01570	COG0330	HflC and HflK could
AD2_01572	COG3583	domain protein
AD2_01572	COG3584	3D domain protein
AD2_01574	COG2273	Hydrolase Family 16
AD2_01575	COG4447	cellulose binding
AD2_01581	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AD2_01584	COG1942	4-Oxalocrotonate Tautomerase
AD2_01589	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AD2_01594	COG3949	Membrane
AD2_01598	COG2273	Hydrolase Family 16
AD2_01599	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AD2_01603	COG0631	protein serine/threonine phosphatase activity
AD2_01604	COG0515	serine threonine protein kinase
AD2_01604	COG2815	serine threonine protein kinase
AD2_01614	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_01616	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AD2_01617	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AD2_01618	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AD2_01619	COG1321	iron dependent repressor
AD2_01621	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AD2_01621	COG1918	ferrous iron import across plasma membrane
AD2_01623	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AD2_01627	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AD2_01629	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AD2_01630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AD2_01635	COG0791	NLP P60 protein
AD2_01638	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AD2_01639	COG0352	thiamine-phosphate diphosphorylase activity
AD2_01641	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AD2_01642	COG2022	thiamine diphosphate biosynthetic process
AD2_01643	COG2022	thiamine diphosphate biosynthetic process
AD2_01643	COG2104	thiamine diphosphate biosynthetic process
AD2_01644	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AD2_01649	COG2226	methyltransferase
AD2_01658	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AD2_01660	COG1201	RNA secondary structure unwinding
AD2_01672	COG2204	response regulator
AD2_01674	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AD2_01675	COG0436	Aminotransferase
AD2_01676	COG0778	Nitroreductase
AD2_01679	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AD2_01680	COG1162	GTPase activity
AD2_01681	COG0515	serine threonine protein kinase
AD2_01681	COG2815	serine threonine protein kinase
AD2_01682	COG0631	protein serine/threonine phosphatase activity
AD2_01683	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AD2_01684	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AD2_01684	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AD2_01685	COG2738	Putative neutral zinc metallopeptidase
AD2_01687	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AD2_01688	COG0242	peptide deformylase activity
AD2_01689	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AD2_01694	COG1477	protein flavinylation
AD2_01695	COG1252	NADH dehydrogenase
AD2_01698	COG0726	polysaccharide deacetylase
AD2_01699	COG0367	asparagine synthase
AD2_01700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AD2_01701	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AD2_01702	COG0583	DNA-binding transcription factor activity
AD2_01704	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AD2_01705	COG0326	Molecular chaperone. Has ATPase activity
AD2_01706	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AD2_01707	COG1121	(ABC) transporter
AD2_01708	COG0803	Belongs to the bacterial solute-binding protein 9 family
AD2_01709	COG0735	belongs to the Fur family
AD2_01711	COG0631	protein serine/threonine phosphatase activity
AD2_01712	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_01715	COG0577	efflux transmembrane transporter activity
AD2_01715	COG1136	(ABC) transporter
AD2_01716	COG1136	(ABC) transporter
AD2_01717	COG5002	protein histidine kinase activity
AD2_01717	COG3850	Histidine kinase
AD2_01718	COG0745	RESPONSE REGULATOR receiver
AD2_01719	COG4447	cellulose binding
AD2_01719	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_01721	COG2274	protein secretion by the type I secretion system
AD2_01730	COG5002	protein histidine kinase activity
AD2_01731	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AD2_01734	COG2176	DNA-directed DNA polymerase activity
AD2_01735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AD2_01737	COG2843	Capsule synthesis protein
AD2_01744	COG1191	sigma factor activity
AD2_01746	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AD2_01747	COG1776	CheC inhibitor of MCP methylation
AD2_01748	COG0835	chemotaxis
AD2_01749	COG0643	Histidine kinase
AD2_01749	COG2198	Histidine kinase
AD2_01750	COG2201	protein-glutamate methylesterase activity
AD2_01753	COG1419	protein localization to endoplasmic reticulum
AD2_01754	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AD2_01755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AD2_01756	COG1684	flagellar biosynthetic protein fliR
AD2_01757	COG1987	bacterial-type flagellum assembly
AD2_01758	COG1338	Plays a role in the flagellum-specific transport system
AD2_01760	COG2201	protein-glutamate methylesterase activity
AD2_01761	COG1776	CheC inhibitor of MCP methylation
AD2_01761	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AD2_01762	COG1776	CheC inhibitor of MCP methylation
AD2_01762	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AD2_01763	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AD2_01765	COG1582	Flagellar protein (FlbD)
AD2_01768	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AD2_01772	COG1157	protein secretion by the type III secretion system
AD2_01773	COG1317	bacterial-type flagellum organization
AD2_01774	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AD2_01776	COG1677	Flagellar hook-basal body complex protein FliE
AD2_01777	COG1558	bacterial-type flagellum-dependent cell motility
AD2_01778	COG1815	bacterial-type flagellum-dependent cell motility
AD2_01779	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AD2_01780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AD2_01781	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AD2_01781	COG0758	DNA mediated transformation
AD2_01782	COG0708	Exodeoxyribonuclease III
AD2_01783	COG3304	Inner membrane component domain
AD2_01785	COG0606	chelatase, subunit chli
AD2_01790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AD2_01791	COG1873	PFAM PRC-barrel domain
AD2_01792	COG1191	sigma factor activity
AD2_01793	COG1191	sigma factor activity
AD2_01795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AD2_01796	COG0849	cell division
AD2_01797	COG3856	small basic protein
AD2_01798	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AD2_01799	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_01800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AD2_01801	COG3442	glutamine amidotransferase
AD2_01802	COG3328	transposase activity
AD2_01803	COG4447	cellulose binding
AD2_01810	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AD2_01818	COG1454	alcohol dehydrogenase
AD2_01818	COG1012	belongs to the aldehyde dehydrogenase family
AD2_01819	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AD2_01820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AD2_01822	COG0612	Peptidase, M16
AD2_01823	COG1185	polyribonucleotide nucleotidyltransferase activity
AD2_01824	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AD2_01827	COG3546	catalase activity
AD2_01829	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_01829	COG2273	Hydrolase Family 16
AD2_01832	COG2848	UPF0210 protein
AD2_01833	COG3830	Belongs to the UPF0237 family
AD2_01838	COG4447	cellulose binding
AD2_01839	COG1191	sigma factor activity
AD2_01844	COG0393	Putative heavy-metal-binding
AD2_01845	COG1132	(ABC) transporter
AD2_01846	COG1132	(ABC) transporter
AD2_01847	COG1869	D-ribose catabolic process
AD2_01850	COG1172	Belongs to the binding-protein-dependent transport system permease family
AD2_01851	COG1129	ABC transporter
AD2_01852	COG1940	carbohydrate kinase activity
AD2_01853	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AD2_01854	COG1063	alcohol dehydrogenase
AD2_01857	COG1136	(ABC) transporter
AD2_01857	COG0577	efflux transmembrane transporter activity
AD2_01867	COG0519	Catalyzes the synthesis of GMP from XMP
AD2_01868	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AD2_01871	COG3328	transposase activity
AD2_01873	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AD2_01874	COG1691	(AIR) carboxylase
AD2_01875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AD2_01878	COG3620	sequence-specific DNA binding
AD2_01879	COG0436	Aminotransferase
AD2_01880	COG1522	sequence-specific DNA binding
AD2_01883	COG3118	belongs to the thioredoxin family
AD2_01885	COG3328	transposase activity
AD2_01890	COG3328	transposase activity
AD2_01891	COG1379	DNA repair
AD2_01892	COG1924	4 iron, 4 sulfur cluster binding
AD2_01895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AD2_01896	COG0681	Belongs to the peptidase S26 family
AD2_01897	COG0191	fructose-bisphosphate aldolase activity
AD2_01898	COG0205	6-phosphofructokinase activity
AD2_01900	COG0039	L-malate dehydrogenase activity
AD2_01901	COG0281	malic enzyme
AD2_01906	COG0784	Response regulator, receiver
AD2_01906	COG2205	protein histidine kinase activity
AD2_01913	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AD2_01915	COG2226	methyltransferase
AD2_01918	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AD2_01919	COG3266	domain, Protein
AD2_01919	COG2911	Protein conserved in bacteria
AD2_01919	COG1361	Conserved repeat domain
AD2_01923	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AD2_01923	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AD2_01924	COG0525	valine-tRNA ligase activity
AD2_01926	COG1472	Belongs to the glycosyl hydrolase 3 family
AD2_01930	COG1376	ErfK ybiS ycfS ynhG family protein
AD2_01932	COG5183	chlorophyll binding
AD2_01932	COG2133	pyrroloquinoline quinone binding
AD2_01933	COG1191	sigma factor activity
AD2_01936	COG0542	response to heat
AD2_01939	COG3583	domain protein
AD2_01939	COG3584	3D domain protein
AD2_01940	COG0556	nucleotide-excision repair
AD2_01943	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AD2_01944	COG0187	DNA topoisomerase II activity
AD2_01948	COG2966	Psort location CytoplasmicMembrane, score
AD2_01949	COG2340	Cysteine-rich secretory protein family
AD2_01950	COG0534	Mate efflux family protein
AD2_01951	COG0840	transmembrane signaling receptor activity
AD2_01962	COG1331	Highly conserved protein containing a thioredoxin domain
AD2_01963	COG0460	homoserine dehydrogenase
AD2_01964	COG1199	ATP-dependent helicase activity
AD2_01965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_01966	COG2205	protein histidine kinase activity
AD2_01966	COG0784	Response regulator, receiver
AD2_01967	COG2205	protein histidine kinase activity
AD2_01969	COG0538	isocitrate dehydrogenase activity
AD2_01971	COG0667	Aldo Keto reductase
AD2_01972	COG0297	glycogen (starch) synthase activity
AD2_01975	COG0564	pseudouridine synthase activity
AD2_01976	COG0116	Belongs to the methyltransferase superfamily
AD2_01976	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AD2_01978	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AD2_01979	COG3459	Glycosyltransferase 36 associated
AD2_01980	COG4733	cellulase activity
AD2_01980	COG4447	cellulose binding
AD2_01981	COG2199	diguanylate cyclase activity
AD2_01981	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_01982	COG1686	Belongs to the peptidase S11 family
AD2_01983	COG4733	cellulase activity
AD2_01983	COG4447	cellulose binding
AD2_01985	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_01986	COG1191	sigma factor activity
AD2_01987	COG4447	cellulose binding
AD2_01988	COG0840	transmembrane signaling receptor activity
AD2_01989	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AD2_01992	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AD2_01994	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AD2_01996	COG4447	cellulose binding
AD2_01998	COG1609	Transcriptional regulator
AD2_02001	COG0714	Associated with various cellular activities
AD2_02004	COG1690	Belongs to the RtcB family
AD2_02007	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AD2_02008	COG3401	FG-GAP repeat protein
AD2_02010	COG2217	Heavy metal translocating P-type atpase
AD2_02011	COG3409	Peptidoglycan-binding domain 1 protein
AD2_02011	COG3773	Cell wall hydrolase
AD2_02015	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_02016	COG0667	Aldo Keto reductase
AD2_02018	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_02019	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AD2_02021	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AD2_02032	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AD2_02035	COG3328	transposase activity
AD2_02043	COG1408	metallophosphoesterase
AD2_02044	COG0166	Belongs to the GPI family
AD2_02046	COG0072	phenylalanine-tRNA ligase activity
AD2_02046	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AD2_02047	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AD2_02049	COG2723	6-phospho-beta-galactosidase activity
AD2_02051	COG2273	Hydrolase Family 16
AD2_02052	COG1609	Transcriptional regulator
AD2_02053	COG1215	transferase activity, transferring glycosyl groups
AD2_02063	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AD2_02064	COG0493	'glutamate synthase
AD2_02064	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AD2_02065	COG0069	glutamate synthase activity
AD2_02066	COG0067	glutamate synthase
AD2_02071	COG0475	glutathione-regulated potassium exporter activity
AD2_02072	COG2273	Hydrolase Family 16
AD2_02073	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AD2_02074	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AD2_02075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AD2_02076	COG5401	PFAM Sporulation and spore germination
AD2_02077	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AD2_02078	COG0860	N-Acetylmuramoyl-L-alanine amidase
AD2_02080	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AD2_02081	COG2255	four-way junction helicase activity
AD2_02082	COG0632	four-way junction helicase activity
AD2_02083	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AD2_02084	COG0137	argininosuccinate synthase activity
AD2_02085	COG0165	Argininosuccinate lyase
AD2_02089	COG1368	sulfuric ester hydrolase activity
AD2_02090	COG0493	'glutamate synthase
AD2_02090	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AD2_02095	COG2201	protein-glutamate methylesterase activity
AD2_02096	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AD2_02098	COG1534	Rna-binding protein
AD2_02099	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AD2_02100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AD2_02102	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AD2_02106	COG1470	cell adhesion involved in biofilm formation
AD2_02107	COG3906	Belongs to the UPF0473 family
AD2_02108	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AD2_02109	COG0667	Aldo Keto reductase
AD2_02110	COG4472	Bacterial protein of unknown function (DUF965)
AD2_02111	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AD2_02114	COG0557	exoribonuclease II activity
AD2_02118	COG0148	phosphopyruvate hydratase activity
AD2_02119	COG2199	diguanylate cyclase activity
AD2_02119	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AD2_02120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AD2_02121	COG0149	triose-phosphate isomerase activity
AD2_02122	COG0126	phosphoglycerate kinase activity
AD2_02127	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_02128	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AD2_02129	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AD2_02130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AD2_02141	COG1366	Belongs to the anti-sigma-factor antagonist family
AD2_02142	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AD2_02143	COG1481	regulation of sporulation
AD2_02145	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AD2_02146	COG1660	Displays ATPase and GTPase activities
AD2_02147	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AD2_02148	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AD2_02149	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AD2_02152	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AD2_02156	COG0432	Pfam Uncharacterised protein family UPF0047
AD2_02157	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AD2_02158	COG1979	alcohol dehydrogenase
AD2_02160	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AD2_02161	COG1994	Peptidase M50
AD2_02161	COG0517	IMP dehydrogenase activity
AD2_02162	COG0739	heme binding
AD2_02164	COG1803	Methylglyoxal synthase
AD2_02165	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AD2_02166	COG2894	cell division
AD2_02167	COG0850	regulation of cytokinetic process
AD2_02168	COG0768	penicillin binding
AD2_02171	COG1077	Cell shape determining protein MreB Mrl
AD2_02172	COG0424	maF-like protein
AD2_02177	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AD2_02178	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AD2_02179	COG0835	chemotaxis
AD2_02188	COG4447	cellulose binding
AD2_02188	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_02189	COG0017	Asparaginyl-tRNA synthetase
AD2_02190	COG2502	aspartate--ammonia ligase
AD2_02191	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AD2_02195	COG1283	sodium-dependent phosphate transmembrane transporter activity
AD2_02197	COG1368	sulfuric ester hydrolase activity
AD2_02198	COG1268	BioY protein
AD2_02199	COG0653	protein targeting
AD2_02200	COG4447	cellulose binding
AD2_02201	COG1191	sigma factor activity
AD2_02205	COG1649	PFAM Uncharacterised BCR, COG1649
AD2_02206	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AD2_02215	COG3693	PFAM glycoside hydrolase, family 10
AD2_02215	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02215	COG2382	esterase
AD2_02216	COG4733	cellulase activity
AD2_02216	COG4447	cellulose binding
AD2_02217	COG1160	GTP binding
AD2_02219	COG4447	cellulose binding
AD2_02219	COG4733	cellulase activity
AD2_02220	COG0840	transmembrane signaling receptor activity
AD2_02221	COG0835	chemotaxis
AD2_02222	COG0840	transmembrane signaling receptor activity
AD2_02223	COG0835	chemotaxis
AD2_02225	COG1151	hydroxylamine reductase activity
AD2_02229	COG4124	Belongs to the glycosyl hydrolase 26 family
AD2_02234	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_02235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_02236	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AD2_02238	COG4106	trans-aconitate 2-methyltransferase activity
AD2_02239	COG2267	carboxylic ester hydrolase activity
AD2_02240	COG0156	8-amino-7-oxononanoate synthase activity
AD2_02241	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AD2_02242	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AD2_02247	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02257	COG3328	transposase activity
AD2_02261	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AD2_02265	COG1595	DNA-templated transcription, initiation
AD2_02267	COG4124	Belongs to the glycosyl hydrolase 26 family
AD2_02267	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_02271	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AD2_02272	COG0717	Belongs to the dCTP deaminase family
AD2_02275	COG2409	Drug exporters of the RND superfamily
AD2_02277	COG0561	phosphatase activity
AD2_02280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AD2_02280	COG0426	domain, Protein
AD2_02281	COG0494	nUDIX hydrolase
AD2_02283	COG0840	transmembrane signaling receptor activity
AD2_02288	COG1695	Transcriptional regulator
AD2_02292	COG0840	transmembrane signaling receptor activity
AD2_02293	COG0004	ammonium transporteR
AD2_02294	COG1132	(ABC) transporter
AD2_02295	COG1132	(ABC) transporter
AD2_02299	COG1361	Conserved repeat domain
AD2_02303	COG1393	Belongs to the ArsC family
AD2_02324	COG0577	efflux transmembrane transporter activity
AD2_02325	COG1136	(ABC) transporter
AD2_02326	COG2205	protein histidine kinase activity
AD2_02327	COG0745	RESPONSE REGULATOR receiver
AD2_02334	COG1131	(ABC) transporter
AD2_02336	COG3620	sequence-specific DNA binding
AD2_02338	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AD2_02339	COG0154	amidase activity
AD2_02341	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AD2_02345	COG1024	Enoyl-CoA hydratase
AD2_02346	COG4106	trans-aconitate 2-methyltransferase activity
AD2_02347	COG2140	Oxalate decarboxylase
AD2_02351	COG1464	Belongs to the NlpA lipoprotein family
AD2_02352	COG2011	ABC-type metal ion transport system permease component
AD2_02353	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AD2_02355	COG0626	cystathionine gamma-synthase activity
AD2_02356	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AD2_02364	COG0535	radical SAM domain protein
AD2_02365	COG2873	o-acetylhomoserine
AD2_02366	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AD2_02367	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_02369	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AD2_02371	COG0813	purine-nucleoside phosphorylase activity
AD2_02372	COG1744	ABC transporter substrate-binding protein PnrA-like
AD2_02373	COG1328	CTP reductase activity
AD2_02374	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AD2_02375	COG3845	ABC transporter
AD2_02376	COG4603	Belongs to the binding-protein-dependent transport system permease family
AD2_02377	COG1079	Belongs to the binding-protein-dependent transport system permease family
AD2_02378	COG0295	cytidine deaminase activity
AD2_02380	COG2207	Transcriptional regulator
AD2_02380	COG4753	response regulator
AD2_02383	COG3842	ATPase activity
AD2_02394	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AD2_02405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AD2_02409	COG3409	Peptidoglycan-binding domain 1 protein
AD2_02409	COG5632	N-Acetylmuramoyl-L-alanine amidase
AD2_02425	COG0740	serine-type endopeptidase activity
AD2_02426	COG4695	Portal protein
AD2_02427	COG1802	Transcriptional regulator
AD2_02427	COG4626	Terminase
AD2_02441	COG1136	(ABC) transporter
AD2_02443	COG2205	protein histidine kinase activity
AD2_02444	COG0745	RESPONSE REGULATOR receiver
AD2_02454	COG1120	ATPase activity
AD2_02455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AD2_02456	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AD2_02458	COG0739	heme binding
AD2_02462	COG0577	efflux transmembrane transporter activity
AD2_02464	COG1136	(ABC) transporter
AD2_02472	COG1592	Rubrerythrin
AD2_02473	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AD2_02474	COG1067	ATP-dependent peptidase activity
AD2_02475	COG0456	acetyltransferase
AD2_02476	COG1214	PFAM Peptidase M22, glycoprotease
AD2_02477	COG0802	atpase or kinase
AD2_02478	COG1228	amidohydrolase
AD2_02483	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AD2_02484	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AD2_02486	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AD2_02487	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AD2_02489	COG1215	transferase activity, transferring glycosyl groups
AD2_02490	COG0542	response to heat
AD2_02491	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AD2_02492	COG3880	PFAM UvrB UvrC protein
AD2_02496	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AD2_02497	COG0287	Prephenate dehydrogenase
AD2_02498	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AD2_02499	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AD2_02500	COG0488	(ABC) transporter
AD2_02502	COG1122	ATPase activity
AD2_02504	COG0310	cobalt ion transport
AD2_02505	COG0860	N-Acetylmuramoyl-L-alanine amidase
AD2_02506	COG0745	RESPONSE REGULATOR receiver
AD2_02510	COG1595	DNA-templated transcription, initiation
AD2_02513	COG0829	nickel cation binding
AD2_02514	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AD2_02516	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AD2_02517	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AD2_02518	COG0804	urea catabolic process
AD2_02519	COG0832	Belongs to the urease beta subunit family
AD2_02520	COG0831	urea catabolic process
AD2_02526	COG4753	response regulator
AD2_02526	COG2207	Transcriptional regulator
AD2_02528	COG4251	negative regulation of phosphorylation
AD2_02544	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AD2_02546	COG1606	tRNA processing
AD2_02548	COG1959	2 iron, 2 sulfur cluster binding
AD2_02549	COG1959	2 iron, 2 sulfur cluster binding
AD2_02550	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AD2_02551	COG5002	protein histidine kinase activity
AD2_02552	COG0745	RESPONSE REGULATOR receiver
AD2_02553	COG2217	Heavy metal translocating P-type atpase
AD2_02557	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AD2_02558	COG1278	Cold shock
AD2_02559	COG3695	enzyme binding
AD2_02562	COG3409	Peptidoglycan-binding domain 1 protein
AD2_02562	COG0793	Belongs to the peptidase S41A family
AD2_02564	COG2177	Part of the ABC transporter FtsEX involved in
AD2_02565	COG2884	Cell division ATP-binding protein ftsE
AD2_02566	COG3835	regulator
AD2_02567	COG3842	ATPase activity
AD2_02568	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AD2_02569	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AD2_02571	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AD2_02572	COG0505	Belongs to the CarA family
AD2_02573	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AD2_02574	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AD2_02577	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AD2_02581	COG1695	Transcriptional regulator
AD2_02582	COG1408	metallophosphoesterase
AD2_02584	COG1876	peptidase activity
AD2_02586	COG3328	transposase activity
AD2_02588	COG0726	polysaccharide deacetylase
AD2_02592	COG0300	oxidoreductase activity
AD2_02592	COG3321	synthase
AD2_02592	COG0318	PFAM AMP-dependent synthetase and ligase
AD2_02592	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AD2_02592	COG1028	Short-chain dehydrogenase reductase Sdr
AD2_02601	COG5002	protein histidine kinase activity
AD2_02602	COG0745	RESPONSE REGULATOR receiver
AD2_02603	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AD2_02604	COG1982	Orn Lys Arg decarboxylase major
AD2_02605	COG1285	pathogenesis
AD2_02607	COG1695	Transcriptional regulator
AD2_02609	COG0504	CTP synthase activity
AD2_02614	COG0793	Belongs to the peptidase S41A family
AD2_02614	COG3409	Peptidoglycan-binding domain 1 protein
AD2_02617	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AD2_02619	COG0018	arginyl-trna synthetase
AD2_02621	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AD2_02622	COG1181	Belongs to the D-alanine--D-alanine ligase family
AD2_02623	COG2239	Acts as a magnesium transporter
AD2_02628	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AD2_02629	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AD2_02630	COG0492	ferredoxin-NADP+ reductase activity
AD2_02632	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AD2_02633	COG0785	Cytochrome C biogenesis protein
AD2_02640	COG2183	response to ionizing radiation
AD2_02645	COG2226	methyltransferase
AD2_02647	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AD2_02649	COG3693	PFAM glycoside hydrolase, family 10
AD2_02649	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02649	COG2382	esterase
AD2_02650	COG3634	alkyl hydroperoxide reductase activity
AD2_02651	COG0450	alkyl hydroperoxide reductase
AD2_02654	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AD2_02686	COG3328	transposase activity
AD2_02692	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AD2_02703	COG3328	transposase activity
AD2_02719	COG0457	Tetratricopeptide repeat
AD2_02719	COG0515	serine threonine protein kinase
AD2_02725	COG1074	ATP-dependent DNA helicase activity
AD2_02726	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AD2_02750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AD2_02753	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AD2_02755	COG0697	spore germination
AD2_02758	COG0215	cysteine-tRNA ligase activity
AD2_02759	COG1045	serine acetyltransferase
AD2_02766	COG1473	amidohydrolase
AD2_02767	COG2155	Conserved Protein
AD2_02769	COG0217	transcriptional regulatory protein
AD2_02771	COG5002	protein histidine kinase activity
AD2_02773	COG1739	Uncharacterized protein family UPF0029
AD2_02774	COG0681	Belongs to the peptidase S26 family
AD2_02775	COG0494	nUDIX hydrolase
AD2_02776	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AD2_02778	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AD2_02779	COG0756	dUTP diphosphatase activity
AD2_02780	COG0826	peptidase U32
AD2_02781	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AD2_02783	COG5297	Belongs to the glycosyl hydrolase family 6
AD2_02786	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AD2_02787	COG3583	domain protein
AD2_02787	COG3584	3D domain protein
AD2_02789	COG0084	hydrolase, TatD family'
AD2_02790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AD2_02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AD2_02792	COG0700	Nucleoside recognition
AD2_02793	COG2715	membrane protein required for spore maturation
AD2_02794	COG2002	toxin-antitoxin pair type II binding
AD2_02795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AD2_02796	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AD2_02798	COG1774	PSP1 C-terminal conserved region
AD2_02799	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AD2_02800	COG1728	Protein conserved in bacteria
AD2_02802	COG1982	Orn Lys Arg decarboxylase major
AD2_02805	COG1136	(ABC) transporter
AD2_02808	COG5002	protein histidine kinase activity
AD2_02810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AD2_02811	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AD2_02813	COG3693	PFAM glycoside hydrolase, family 10
AD2_02814	COG1191	sigma factor activity
AD2_02819	COG0395	ABC-type sugar transport system, permease component
AD2_02820	COG1175	transmembrane transport
AD2_02821	COG0714	Associated with various cellular activities
AD2_02829	COG3940	Belongs to the glycosyl hydrolase 43 family
AD2_02830	COG3940	Belongs to the glycosyl hydrolase 43 family
AD2_02833	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AD2_02834	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AD2_02835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AD2_02836	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AD2_02846	COG1361	Conserved repeat domain
AD2_02854	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AD2_02857	COG1773	rubredoxin
AD2_02862	COG1408	metallophosphoesterase
AD2_02865	COG0254	rRNA binding
AD2_02866	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AD2_02878	COG0038	chloride channel
AD2_02879	COG0037	tRNA processing
AD2_02881	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AD2_02882	COG1295	ribonuclease BN
AD2_02883	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AD2_02884	COG0629	single-stranded DNA binding
AD2_02885	COG0360	Binds together with S18 to 16S ribosomal RNA
AD2_02887	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AD2_02888	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AD2_02890	COG3693	PFAM glycoside hydrolase, family 10
AD2_02890	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02890	COG2382	esterase
AD2_02891	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02892	COG3693	PFAM glycoside hydrolase, family 10
AD2_02892	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02892	COG2382	esterase
AD2_02893	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02893	COG2382	esterase
AD2_02893	COG3693	PFAM glycoside hydrolase, family 10
AD2_02894	COG3507	Belongs to the glycosyl hydrolase 43 family
AD2_02895	COG3250	beta-galactosidase activity
AD2_02898	COG4978	Transcriptional regulator
AD2_02898	COG0789	Transcriptional regulator
AD2_02899	COG0577	efflux transmembrane transporter activity
AD2_02900	COG1136	(ABC) transporter
AD2_02901	COG5002	protein histidine kinase activity
AD2_02902	COG0745	RESPONSE REGULATOR receiver
AD2_02910	COG0302	gtp cyclohydrolase
AD2_02911	COG1181	Belongs to the D-alanine--D-alanine ligase family
AD2_02911	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AD2_02912	COG4242	Belongs to the peptidase S51 family
AD2_02914	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AD2_02915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AD2_02916	COG0473	3-isopropylmalate dehydrogenase activity
AD2_02917	COG0066	3-isopropylmalate dehydratase activity
AD2_02918	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AD2_02919	COG2207	Transcriptional regulator
AD2_02920	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AD2_02924	COG1516	flagellar protein fliS
AD2_02925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AD2_02927	COG1088	dTDP-glucose 4,6-dehydratase activity
AD2_02928	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AD2_02931	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AD2_02934	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AD2_02936	COG2089	acid synthase
AD2_02937	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AD2_02938	COG2226	methyltransferase
AD2_02939	COG1086	Polysaccharide biosynthesis protein
AD2_02943	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AD2_02944	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AD2_02946	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AD2_02947	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AD2_02949	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AD2_02950	COG1256	bacterial-type flagellum assembly
AD2_02950	COG4786	Flagellar basal body rod
AD2_02955	COG1040	competence protein
AD2_02956	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AD2_02958	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AD2_02960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AD2_02961	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AD2_02962	COG0037	tRNA processing
AD2_02963	COG0305	Participates in initiation and elongation during chromosome replication
AD2_02964	COG0359	binds to the 23S rRNA
AD2_02965	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AD2_02967	COG1605	Chorismate mutase
AD2_02967	COG0077	Prephenate dehydratase
AD2_02969	COG1269	ATP hydrolysis coupled proton transport
AD2_02970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AD2_02971	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
AD2_02974	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
AD2_02975	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
AD2_02976	COG1394	ATPase activity, coupled to movement of substances
AD2_02977	COG0488	(ABC) transporter
AD2_02984	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AD2_02987	COG0765	amino acid transport
AD2_02989	COG2201	protein-glutamate methylesterase activity
AD2_02990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AD2_02992	COG0643	Histidine kinase
AD2_02992	COG2198	Histidine kinase
AD2_02993	COG0835	chemotaxis
AD2_02994	COG0582	viral genome integration into host DNA
AD2_02995	COG3708	Transcriptional regulator
AD2_02995	COG2207	Transcriptional regulator
AD2_02998	COG1131	(ABC) transporter
AD2_03004	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AD2_03005	COG1518	maintenance of DNA repeat elements
AD2_03013	COG1968	undecaprenyl-diphosphatase activity
AD2_03014	COG0534	Mate efflux family protein
AD2_03022	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AD2_03023	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AD2_03024	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AD2_03028	COG5002	protein histidine kinase activity
AD2_03029	COG0745	RESPONSE REGULATOR receiver
AD2_03034	COG0438	transferase activity, transferring glycosyl groups
AD2_03036	COG0438	transferase activity, transferring glycosyl groups
AD2_03042	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AD2_03043	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AD2_03046	COG1361	Conserved repeat domain
AD2_03048	COG3773	Cell wall hydrolase
AD2_03050	COG0517	IMP dehydrogenase activity
AD2_03053	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AD2_03054	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AD2_03059	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AD2_03060	COG4447	cellulose binding
AD2_03060	COG4733	cellulase activity
AD2_03061	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AD2_03062	COG1475	DNA binding
AD2_03063	COG0357	Ribosomal RNA small subunit methyltransferase G
AD2_03064	COG0445	tRNA wobble uridine modification
AD2_03065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AD2_03066	COG1847	R3H domain protein
AD2_03067	COG0706	membrane insertase activity
AD2_03068	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AD2_03070	COG0230	Belongs to the bacterial ribosomal protein bL34 family