locus-tag	class	description
Cthe_0015	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_0020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Cthe_0021	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Cthe_0022	COG0156	8-amino-7-oxononanoate synthase activity
Cthe_0023	COG2267	carboxylic ester hydrolase activity
Cthe_0024	COG4106	trans-aconitate 2-methyltransferase activity
Cthe_0032	COG4124	Belongs to the glycosyl hydrolase 26 family
Cthe_0036	COG1151	hydroxylamine reductase activity
Cthe_0039	COG0840	transmembrane signaling receptor activity
Cthe_0040	COG4447	cellulose binding
Cthe_0040	COG4733	cellulase activity
Cthe_0042	COG1160	GTP binding
Cthe_0043	COG4447	cellulose binding
Cthe_0043	COG4733	cellulase activity
Cthe_0044	COG3693	PFAM glycoside hydrolase, family 10
Cthe_0044	COG2382	esterase
Cthe_0044	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_0053	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Cthe_0054	COG1649	PFAM Uncharacterised BCR, COG1649
Cthe_0058	COG1191	sigma factor activity
Cthe_0059	COG4447	cellulose binding
Cthe_0060	COG0653	protein targeting
Cthe_0061	COG1268	BioY protein
Cthe_0062	COG1368	sulfuric ester hydrolase activity
Cthe_0064	COG1283	sodium-dependent phosphate transmembrane transporter activity
Cthe_0068	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Cthe_0069	COG2502	aspartate--ammonia ligase
Cthe_0070	COG0017	Asparaginyl-tRNA synthetase
Cthe_0071	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_0071	COG4447	cellulose binding
Cthe_0080	COG0835	chemotaxis
Cthe_0081	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Cthe_0082	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Cthe_0087	COG0424	maF-like protein
Cthe_0088	COG1077	Cell shape determining protein MreB Mrl
Cthe_0091	COG0768	penicillin binding
Cthe_0092	COG0850	regulation of cytokinetic process
Cthe_0093	COG2894	cell division
Cthe_0094	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Cthe_0095	COG1803	Methylglyoxal synthase
Cthe_0097	COG0739	heme binding
Cthe_0098	COG1994	Peptidase M50
Cthe_0098	COG0517	IMP dehydrogenase activity
Cthe_0099	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Cthe_0101	COG1979	alcohol dehydrogenase
Cthe_0102	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Cthe_0103	COG0432	Pfam Uncharacterised protein family UPF0047
Cthe_0107	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Cthe_0110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Cthe_0111	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Cthe_0112	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Cthe_0113	COG1660	Displays ATPase and GTPase activities
Cthe_0114	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Cthe_0116	COG1481	regulation of sporulation
Cthe_0117	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Cthe_0118	COG1366	Belongs to the anti-sigma-factor antagonist family
Cthe_0130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Cthe_0131	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Cthe_0132	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Cthe_0133	COG0318	PFAM AMP-dependent synthetase and ligase
Cthe_0138	COG0126	phosphoglycerate kinase activity
Cthe_0139	COG0149	triose-phosphate isomerase activity
Cthe_0140	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Cthe_0142	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Cthe_0142	COG2199	diguanylate cyclase activity
Cthe_0143	COG0148	phosphopyruvate hydratase activity
Cthe_0146	COG0557	exoribonuclease II activity
Cthe_0148	COG3328	transposase activity
Cthe_0150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Cthe_0151	COG4472	Bacterial protein of unknown function (DUF965)
Cthe_0152	COG0667	Aldo Keto reductase
Cthe_0153	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Cthe_0154	COG3906	Belongs to the UPF0473 family
Cthe_0155	COG1470	cell adhesion involved in biofilm formation
Cthe_0160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Cthe_0162	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Cthe_0163	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Cthe_0164	COG1534	Rna-binding protein
Cthe_0166	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Cthe_0167	COG2201	protein-glutamate methylesterase activity
Cthe_0173	COG0493	'glutamate synthase
Cthe_0173	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
Cthe_0174	COG1368	sulfuric ester hydrolase activity
Cthe_0178	COG0165	Argininosuccinate lyase
Cthe_0179	COG0137	argininosuccinate synthase activity
Cthe_0180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Cthe_0181	COG0632	four-way junction helicase activity
Cthe_0182	COG2255	four-way junction helicase activity
Cthe_0183	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Cthe_0185	COG0860	N-Acetylmuramoyl-L-alanine amidase
Cthe_0186	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Cthe_0187	COG5401	PFAM Sporulation and spore germination
Cthe_0188	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Cthe_0189	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Cthe_0190	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Cthe_0191	COG2273	Hydrolase Family 16
Cthe_0193	COG0475	glutathione-regulated potassium exporter activity
Cthe_0197	COG0067	glutamate synthase
Cthe_0198	COG0069	glutamate synthase activity
Cthe_0199	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Cthe_0199	COG0493	'glutamate synthase
Cthe_0200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Cthe_0208	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Cthe_0208	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Cthe_0209	COG1215	transferase activity, transferring glycosyl groups
Cthe_0210	COG1609	Transcriptional regulator
Cthe_0211	COG2273	Hydrolase Family 16
Cthe_0212	COG2723	6-phospho-beta-galactosidase activity
Cthe_0214	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Cthe_0215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Cthe_0215	COG0072	phenylalanine-tRNA ligase activity
Cthe_0217	COG0166	Belongs to the GPI family
Cthe_0218	COG1408	metallophosphoesterase
Cthe_0223	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Cthe_0231	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Cthe_0233	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Cthe_0234	COG0318	PFAM AMP-dependent synthetase and ligase
Cthe_0236	COG0667	Aldo Keto reductase
Cthe_0237	COG0745	RESPONSE REGULATOR receiver
Cthe_0239	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Cthe_0243	COG3409	Peptidoglycan-binding domain 1 protein
Cthe_0243	COG3773	Cell wall hydrolase
Cthe_0244	COG2217	Heavy metal translocating P-type atpase
Cthe_0246	COG3401	FG-GAP repeat protein
Cthe_0247	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Cthe_0250	COG1690	Belongs to the RtcB family
Cthe_0253	COG0714	Associated with various cellular activities
Cthe_0256	COG1609	Transcriptional regulator
Cthe_0258	COG4447	cellulose binding
Cthe_0260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Cthe_0262	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Cthe_0265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Cthe_0266	COG0840	transmembrane signaling receptor activity
Cthe_0267	COG4447	cellulose binding
Cthe_0268	COG1191	sigma factor activity
Cthe_0269	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Cthe_0271	COG4447	cellulose binding
Cthe_0271	COG4733	cellulase activity
Cthe_0272	COG1686	Belongs to the peptidase S11 family
Cthe_0273	COG2199	diguanylate cyclase activity
Cthe_0273	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Cthe_0274	COG4733	cellulase activity
Cthe_0274	COG4447	cellulose binding
Cthe_0275	COG3459	Glycosyltransferase 36 associated
Cthe_0276	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Cthe_0277	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Cthe_0277	COG0116	Belongs to the methyltransferase superfamily
Cthe_0278	COG0564	pseudouridine synthase activity
Cthe_0282	COG0297	glycogen (starch) synthase activity
Cthe_0283	COG0667	Aldo Keto reductase
Cthe_0285	COG0538	isocitrate dehydrogenase activity
Cthe_0286	COG2205	protein histidine kinase activity
Cthe_0287	COG0784	Response regulator, receiver
Cthe_0287	COG2205	protein histidine kinase activity
Cthe_0288	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Cthe_0289	COG1199	ATP-dependent helicase activity
Cthe_0290	COG0460	homoserine dehydrogenase
Cthe_0291	COG1331	Highly conserved protein containing a thioredoxin domain
Cthe_0292	COG3328	transposase activity
Cthe_0298	COG0840	transmembrane signaling receptor activity
Cthe_0299	COG0534	Mate efflux family protein
Cthe_0300	COG2340	Cysteine-rich secretory protein family
Cthe_0301	COG2966	Psort location CytoplasmicMembrane, score
Cthe_0305	COG0187	DNA topoisomerase II activity
Cthe_0306	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Cthe_0309	COG0556	nucleotide-excision repair
Cthe_0310	COG3583	domain protein
Cthe_0310	COG3584	3D domain protein
Cthe_0312	COG0542	response to heat
Cthe_0315	COG1191	sigma factor activity
Cthe_0316	COG5183	chlorophyll binding
Cthe_0316	COG2133	pyrroloquinoline quinone binding
Cthe_0318	COG1376	ErfK ybiS ycfS ynhG family protein
Cthe_0322	COG1472	Belongs to the glycosyl hydrolase 3 family
Cthe_0324	COG0525	valine-tRNA ligase activity
Cthe_0325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Cthe_0325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Cthe_0327	COG1361	Conserved repeat domain
Cthe_0327	COG2911	Protein conserved in bacteria
Cthe_0327	COG3266	domain, Protein
Cthe_0328	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Cthe_0330	COG2226	methyltransferase
Cthe_0332	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Cthe_0339	COG2205	protein histidine kinase activity
Cthe_0339	COG0784	Response regulator, receiver
Cthe_0344	COG0281	malic enzyme
Cthe_0345	COG0039	L-malate dehydrogenase activity
Cthe_0347	COG0205	6-phosphofructokinase activity
Cthe_0349	COG0191	fructose-bisphosphate aldolase activity
Cthe_0350	COG0681	Belongs to the peptidase S26 family
Cthe_0351	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Cthe_0354	COG1924	4 iron, 4 sulfur cluster binding
Cthe_0355	COG1379	DNA repair
Cthe_0356	COG3328	transposase activity
Cthe_0360	COG3118	belongs to the thioredoxin family
Cthe_0362	COG1522	sequence-specific DNA binding
Cthe_0363	COG0436	Aminotransferase
Cthe_0364	COG3620	sequence-specific DNA binding
Cthe_0367	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Cthe_0368	COG1691	(AIR) carboxylase
Cthe_0369	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Cthe_0371	COG3328	transposase activity
Cthe_0374	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Cthe_0375	COG0519	Catalyzes the synthesis of GMP from XMP
Cthe_0384	COG1136	(ABC) transporter
Cthe_0384	COG0577	efflux transmembrane transporter activity
Cthe_0388	COG1063	alcohol dehydrogenase
Cthe_0389	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Cthe_0390	COG1940	carbohydrate kinase activity
Cthe_0391	COG1129	ABC transporter
Cthe_0392	COG1172	Belongs to the binding-protein-dependent transport system permease family
Cthe_0395	COG1869	D-ribose catabolic process
Cthe_0396	COG1132	(ABC) transporter
Cthe_0397	COG1132	(ABC) transporter
Cthe_0398	COG0393	Putative heavy-metal-binding
Cthe_0403	COG1191	sigma factor activity
Cthe_0404	COG4447	cellulose binding
Cthe_0409	COG3830	Belongs to the UPF0237 family
Cthe_0410	COG2848	UPF0210 protein
Cthe_0412	COG2273	Hydrolase Family 16
Cthe_0412	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_0414	COG3546	catalase activity
Cthe_0417	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Cthe_0418	COG1185	polyribonucleotide nucleotidyltransferase activity
Cthe_0419	COG0612	Peptidase, M16
Cthe_0421	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Cthe_0422	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Cthe_0423	COG1454	alcohol dehydrogenase
Cthe_0423	COG1012	belongs to the aldehyde dehydrogenase family
Cthe_0431	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Cthe_0438	COG4447	cellulose binding
Cthe_0439	COG3442	glutamine amidotransferase
Cthe_0440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Cthe_0441	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Cthe_0442	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Cthe_0443	COG3856	small basic protein
Cthe_0444	COG0849	cell division
Cthe_0445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Cthe_0447	COG1191	sigma factor activity
Cthe_0448	COG1191	sigma factor activity
Cthe_0449	COG1873	PFAM PRC-barrel domain
Cthe_0450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Cthe_0455	COG0606	chelatase, subunit chli
Cthe_0456	COG0432	Pfam Uncharacterised protein family UPF0047
Cthe_0458	COG0708	Exodeoxyribonuclease III
Cthe_0459	COG0758	DNA mediated transformation
Cthe_0459	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Cthe_0460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Cthe_0461	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Cthe_0463	COG1558	bacterial-type flagellum-dependent cell motility
Cthe_0464	COG1677	Flagellar hook-basal body complex protein FliE
Cthe_0466	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Cthe_0467	COG1317	bacterial-type flagellum organization
Cthe_0468	COG1157	protein secretion by the type III secretion system
Cthe_0472	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Cthe_0475	COG1582	Flagellar protein (FlbD)
Cthe_0477	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Cthe_0478	COG1776	CheC inhibitor of MCP methylation
Cthe_0478	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Cthe_0479	COG2201	protein-glutamate methylesterase activity
Cthe_0481	COG1338	Plays a role in the flagellum-specific transport system
Cthe_0482	COG1987	bacterial-type flagellum assembly
Cthe_0483	COG1684	flagellar biosynthetic protein fliR
Cthe_0484	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Cthe_0485	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Cthe_0486	COG1419	protein localization to endoplasmic reticulum
Cthe_0489	COG2201	protein-glutamate methylesterase activity
Cthe_0490	COG0643	Histidine kinase
Cthe_0490	COG2198	Histidine kinase
Cthe_0491	COG0835	chemotaxis
Cthe_0492	COG1776	CheC inhibitor of MCP methylation
Cthe_0493	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Cthe_0504	COG2843	Capsule synthesis protein
Cthe_0506	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Cthe_0507	COG2176	DNA-directed DNA polymerase activity
Cthe_0509	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Cthe_0511	COG5002	protein histidine kinase activity
Cthe_0512	COG0582	viral genome integration into host DNA
Cthe_0515	COG4372	Transposase
Cthe_0521	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Cthe_0534	COG2274	protein secretion by the type I secretion system
Cthe_0536	COG4447	cellulose binding
Cthe_0536	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Cthe_0537	COG0745	RESPONSE REGULATOR receiver
Cthe_0538	COG3850	Histidine kinase
Cthe_0538	COG5002	protein histidine kinase activity
Cthe_0539	COG1136	(ABC) transporter
Cthe_0540	COG0577	efflux transmembrane transporter activity
Cthe_0540	COG1136	(ABC) transporter
Cthe_0543	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_0544	COG0631	protein serine/threonine phosphatase activity
Cthe_0546	COG0735	belongs to the Fur family
Cthe_0547	COG0803	Belongs to the bacterial solute-binding protein 9 family
Cthe_0548	COG1121	(ABC) transporter
Cthe_0549	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Cthe_0550	COG0326	Molecular chaperone. Has ATPase activity
Cthe_0551	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Cthe_0553	COG0583	DNA-binding transcription factor activity
Cthe_0554	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Cthe_0555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Cthe_0556	COG0367	asparagine synthase
Cthe_0557	COG0726	polysaccharide deacetylase
Cthe_0560	COG1252	NADH dehydrogenase
Cthe_0561	COG1477	protein flavinylation
Cthe_0566	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Cthe_0567	COG0242	peptide deformylase activity
Cthe_0568	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Cthe_0570	COG2738	Putative neutral zinc metallopeptidase
Cthe_0571	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Cthe_0571	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Cthe_0572	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Cthe_0573	COG0631	protein serine/threonine phosphatase activity
Cthe_0574	COG2815	serine threonine protein kinase
Cthe_0574	COG0515	serine threonine protein kinase
Cthe_0575	COG1162	GTPase activity
Cthe_0576	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Cthe_0579	COG0778	Nitroreductase
Cthe_0580	COG0436	Aminotransferase
Cthe_0581	COG1293	RNA-binding protein homologous to eukaryotic snRNP
Cthe_0583	COG2204	response regulator
Cthe_0587	COG3328	transposase activity
Cthe_0592	COG2226	methyltransferase
Cthe_0594	COG3328	transposase activity
Cthe_0596	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Cthe_0597	COG2022	thiamine diphosphate biosynthetic process
Cthe_0597	COG2104	thiamine diphosphate biosynthetic process
Cthe_0598	COG2022	thiamine diphosphate biosynthetic process
Cthe_0599	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Cthe_0601	COG0352	thiamine-phosphate diphosphorylase activity
Cthe_0602	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Cthe_0605	COG0791	NLP P60 protein
Cthe_0610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Cthe_0611	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Cthe_0617	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Cthe_0618	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Cthe_0618	COG1918	ferrous iron import across plasma membrane
Cthe_0620	COG1321	iron dependent repressor
Cthe_0621	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Cthe_0622	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Cthe_0623	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Cthe_0625	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_0634	COG0515	serine threonine protein kinase
Cthe_0634	COG2815	serine threonine protein kinase
Cthe_0635	COG0631	protein serine/threonine phosphatase activity
Cthe_0639	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Cthe_0640	COG2273	Hydrolase Family 16
Cthe_0643	COG3949	Membrane
Cthe_0648	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Cthe_0652	COG1942	4-Oxalocrotonate Tautomerase
Cthe_0655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Cthe_0660	COG4447	cellulose binding
Cthe_0661	COG2273	Hydrolase Family 16
Cthe_0664	COG3584	3D domain protein
Cthe_0664	COG3583	domain protein
Cthe_0666	COG0330	HflC and HflK could
Cthe_0667	COG0697	spore germination
Cthe_0672	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Cthe_0673	COG0328	RNA-DNA hybrid ribonuclease activity
Cthe_0675	COG1300	Membrane
Cthe_0676	COG4974	Belongs to the 'phage' integrase family
Cthe_0677	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Cthe_0679	COG1686	Belongs to the peptidase S11 family
Cthe_0681	COG0516	GMP reductase activity
Cthe_0681	COG0517	IMP dehydrogenase activity
Cthe_0684	COG0617	tRNA 3'-terminal CCA addition
Cthe_0684	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Cthe_0684	COG3620	sequence-specific DNA binding
Cthe_0685	COG1994	Peptidase M50
Cthe_0686	COG0180	Tryptophanyl-tRNA synthetase
Cthe_0687	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Cthe_0688	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Cthe_0691	COG3874	Sporulation protein YtfJ
Cthe_0693	COG1187	pseudouridine synthase activity
Cthe_0694	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Cthe_0695	COG0010	Belongs to the arginase family
Cthe_0696	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Cthe_0699	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Cthe_0700	COG0511	ligase activity, forming carbon-carbon bonds
Cthe_0706	COG1737	Transcriptional regulator
Cthe_0707	COG0406	alpha-ribazole phosphatase activity
Cthe_0708	COG2081	HI0933 family
Cthe_0713	COG0204	Acyl-transferase
Cthe_0714	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Cthe_0714	COG0539	negative regulation of cytoplasmic translation
Cthe_0715	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Cthe_0716	COG0105	UTP biosynthetic process
Cthe_0717	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Cthe_0719	COG1959	2 iron, 2 sulfur cluster binding
Cthe_0721	COG0822	iron-sulfur transferase activity
Cthe_0722	COG0482	sulfurtransferase activity
Cthe_0723	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Cthe_0724	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Cthe_0725	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Cthe_0725	COG2199	diguanylate cyclase activity
Cthe_0726	COG1362	aminopeptidase activity
Cthe_0728	COG4974	Belongs to the 'phage' integrase family
Cthe_0729	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Cthe_0732	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Cthe_0735	COG2911	Protein conserved in bacteria
Cthe_0735	COG3266	domain, Protein
Cthe_0735	COG1361	Conserved repeat domain
Cthe_0736	COG1361	Conserved repeat domain
Cthe_0736	COG2911	Protein conserved in bacteria
Cthe_0736	COG3266	domain, Protein
Cthe_0740	COG2188	Transcriptional regulator
Cthe_0741	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Cthe_0743	COG0534	Mate efflux family protein
Cthe_0744	COG0793	Belongs to the peptidase S41A family
Cthe_0744	COG3409	Peptidoglycan-binding domain 1 protein
Cthe_0745	COG4733	cellulase activity
Cthe_0749	COG1176	ABC-type spermidine putrescine transport system, permease component I
Cthe_0750	COG3842	ATPase activity
Cthe_0757	COG2003	Belongs to the UPF0758 family
Cthe_0758	COG0792	nuclease activity
Cthe_0761	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Cthe_0765	COG0335	large ribosomal subunit rRNA binding
Cthe_0766	COG0336	Belongs to the RNA methyltransferase TrmD family
Cthe_0767	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Cthe_0768	COG1837	Belongs to the UPF0109 family
Cthe_0769	COG0228	four-way junction DNA binding
Cthe_0770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Cthe_0771	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Cthe_0773	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Cthe_0774	COG1923	regulation of RNA biosynthetic process
Cthe_0775	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Cthe_0776	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Cthe_0777	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Cthe_0779	COG2340	Cysteine-rich secretory protein family
Cthe_0780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Cthe_0783	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Cthe_0786	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Cthe_0788	COG3599	regulation of cell shape
Cthe_0789	COG2302	S4 RNA-binding domain
Cthe_0791	COG1799	cell septum assembly
Cthe_0792	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Cthe_0794	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Cthe_0795	COG0366	Alpha amylase catalytic
Cthe_0797	COG2755	lipolytic protein G-D-S-L family
Cthe_0797	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Cthe_0799	COG0745	RESPONSE REGULATOR receiver
Cthe_0800	COG5002	protein histidine kinase activity
Cthe_0801	COG3328	transposase activity
Cthe_0803	COG0564	pseudouridine synthase activity
Cthe_0805	COG0745	RESPONSE REGULATOR receiver
Cthe_0807	COG2201	protein-glutamate methylesterase activity
Cthe_0809	COG0835	chemotaxis
Cthe_0810	COG0643	Histidine kinase
Cthe_0810	COG2198	Histidine kinase
Cthe_0811	COG2201	protein-glutamate methylesterase activity
Cthe_0812	COG0745	RESPONSE REGULATOR receiver
Cthe_0813	COG0750	zinc metalloprotease
Cthe_0814	COG0497	DNA recombination
Cthe_0815	COG1438	arginine binding
Cthe_0816	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Cthe_0817	COG3706	GGDEF domain
Cthe_0819	COG1131	(ABC) transporter
Cthe_0825	COG3291	Pkd domain containing protein
Cthe_0827	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Cthe_0828	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Cthe_0830	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Cthe_0832	COG1722	exodeoxyribonuclease VII activity
Cthe_0833	COG1570	exodeoxyribonuclease VII activity
Cthe_0834	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Cthe_0837	COG1302	Protein conserved in bacteria
Cthe_0845	COG3854	ATPases associated with a variety of cellular activities
Cthe_0847	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Cthe_0848	COG0006	proline dipeptidase activity
Cthe_0849	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Cthe_0852	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Cthe_0853	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Cthe_0854	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Cthe_0855	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Cthe_0856	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Cthe_0857	COG1030	water channel activity
Cthe_0858	COG4864	UPF0365 protein
Cthe_0860	COG1592	Rubrerythrin
Cthe_0861	COG1316	TRANSCRIPTIONal
Cthe_0871	COG0135	phosphoribosylanthranilate isomerase activity
Cthe_0872	COG0134	indole-3-glycerol-phosphate synthase activity
Cthe_0873	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Cthe_0874	COG0512	Glutamine amidotransferase of anthranilate synthase
Cthe_0874	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Cthe_0877	COG0012	GTP binding
Cthe_0878	COG0835	chemotaxis
Cthe_0880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Cthe_0881	COG3706	GGDEF domain
Cthe_0882	COG0697	spore germination
Cthe_0885	COG0237	dephospho-CoA kinase activity
Cthe_0886	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Cthe_0886	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Cthe_0890	COG1595	DNA-templated transcription, initiation
Cthe_0891	COG3437	response regulator, receiver
Cthe_0892	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Cthe_0893	COG2384	SAM-dependent methyltransferase
Cthe_0895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Cthe_0896	COG0358	DNA primase activity
Cthe_0897	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Cthe_0900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Cthe_0901	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Cthe_0902	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Cthe_0903	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Cthe_0904	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Cthe_0905	COG1418	mRNA catabolic process
Cthe_0908	COG0564	pseudouridine synthase activity
Cthe_0909	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Cthe_0911	COG1496	oxidoreductase activity
Cthe_0913	COG3547	Transposase (IS116 IS110 IS902 family)
Cthe_0917	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Cthe_0922	COG1748	Saccharopine dehydrogenase
Cthe_0926	COG0552	protein localization to endoplasmic reticulum
Cthe_0929	COG2359	stage V sporulation protein S
Cthe_0931	COG0571	ribonuclease III activity
Cthe_0932	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Cthe_0933	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Cthe_0934	COG1028	Short-chain dehydrogenase reductase Sdr
Cthe_0935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Cthe_0936	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Cthe_0937	COG0416	fatty acid biosynthetic process
Cthe_0938	COG2030	dehydratase
Cthe_0941	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Cthe_0942	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Cthe_0946	COG0588	phosphoglycerate mutase activity
Cthe_0947	COG0167	dihydroorotate dehydrogenase activity
Cthe_0948	COG0543	2 iron, 2 sulfur cluster binding
Cthe_0949	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Cthe_0952	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Cthe_0953	COG0540	Belongs to the ATCase OTCase family
Cthe_0954	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Cthe_0957	COG1862	Preprotein translocase
Cthe_0958	COG0343	queuine tRNA-ribosyltransferase activity
Cthe_0959	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Cthe_0960	COG2385	sporulation resulting in formation of a cellular spore
Cthe_0960	COG2247	cell wall binding repeat
Cthe_0961	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Cthe_0962	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Cthe_0963	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Cthe_0965	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Cthe_0970	COG3328	transposase activity
Cthe_0973	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Cthe_0974	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Cthe_0975	COG0772	Belongs to the SEDS family
Cthe_0976	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Cthe_0977	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Cthe_0978	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Cthe_0979	COG0768	penicillin binding
Cthe_0981	COG0275	rRNA processing
Cthe_0982	COG2001	Belongs to the MraZ family
Cthe_0983	COG0772	Belongs to the SEDS family
Cthe_0984	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Cthe_0985	COG0612	Peptidase, M16
Cthe_0986	COG0612	Peptidase, M16
Cthe_0987	COG0196	riboflavin kinase activity
Cthe_0988	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Cthe_0989	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Cthe_0990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Cthe_0991	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Cthe_0993	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Cthe_0994	COG0195	Participates in both transcription termination and antitermination
Cthe_0995	COG0779	Required for maturation of 30S ribosomal subunits
Cthe_0997	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Cthe_0999	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Cthe_1000	COG0575	Belongs to the CDS family
Cthe_1001	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Cthe_1003	COG0233	cytoplasmic translational termination
Cthe_1004	COG0528	UMP kinase activity
Cthe_1005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Cthe_1006	COG0052	Belongs to the universal ribosomal protein uS2 family
Cthe_1007	COG1217	gtp-binding protein TYPA
Cthe_1008	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Cthe_1009	COG4122	O-methyltransferase activity
Cthe_1010	COG0826	peptidase U32
Cthe_1011	COG0768	penicillin binding
Cthe_1013	COG0628	permease
Cthe_1014	COG1193	negative regulation of DNA recombination
Cthe_1016	COG0860	N-Acetylmuramoyl-L-alanine amidase
Cthe_1016	COG2247	cell wall binding repeat
Cthe_1018	COG0395	ABC-type sugar transport system, permease component
Cthe_1019	COG1175	transmembrane transport
Cthe_1021	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Cthe_1022	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Cthe_1024	COG1160	GTP binding
Cthe_1026	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Cthe_1028	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Cthe_1029	COG0280	phosphate acetyltransferase
Cthe_1031	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Cthe_1032	COG0154	amidase activity
Cthe_1033	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Cthe_1035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Cthe_1039	COG0268	Binds directly to 16S ribosomal RNA
Cthe_1040	COG1466	dna polymerase III delta subunit
Cthe_1041	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Cthe_1048	COG0705	Rhomboid family
Cthe_1048	COG0457	Tetratricopeptide repeat
Cthe_1050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Cthe_1051	COG0728	peptidoglycan biosynthetic process
Cthe_1052	COG1058	Belongs to the CinA family
Cthe_1052	COG1546	Belongs to the CinA family
Cthe_1053	COG0039	L-malate dehydrogenase activity
Cthe_1054	COG0714	Associated with various cellular activities
Cthe_1056	COG1305	Transglutaminase-like
Cthe_1057	COG1983	PspC domain protein
Cthe_1058	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Cthe_1062	COG2720	vancomycin resistance protein
Cthe_1063	COG0301	tRNA thio-modification
Cthe_1064	COG1104	cysteine desulfurase activity
Cthe_1066	COG1381	Involved in DNA repair and RecF pathway recombination
Cthe_1067	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Cthe_1068	COG0295	cytidine deaminase activity
Cthe_1069	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Cthe_1070	COG1480	7TM receptor with intracellular HD hydrolase
Cthe_1071	COG1702	phosphate starvation-inducible protein PhoH
Cthe_1079	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Cthe_1083	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Cthe_1085	COG0438	transferase activity, transferring glycosyl groups
Cthe_1089	COG2359	stage V sporulation protein S
Cthe_1090	COG1692	metallophosphoesterase
Cthe_1091	COG1418	mRNA catabolic process
Cthe_1093	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Cthe_1095	COG1674	ftsk spoiiie
Cthe_1097	COG0740	serine-type endopeptidase activity
Cthe_1105	COG1459	type II secretion system
Cthe_1107	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Cthe_1111	COG0798	PFAM Bile acid sodium symporter
Cthe_1112	COG0640	Transcriptional regulator
Cthe_1113	COG0653	protein targeting
Cthe_1136	COG0515	serine threonine protein kinase
Cthe_1136	COG2815	serine threonine protein kinase
Cthe_1153	COG3706	GGDEF domain
Cthe_1162	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Cthe_1163	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Cthe_1164	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Cthe_1166	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Cthe_1168	COG3885	ferrous iron binding
Cthe_1168	COG2078	PFAM AMMECR1 domain protein
Cthe_1170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Cthe_1176	COG1406	Chemotaxis phosphatase CheX
Cthe_1177	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Cthe_1181	COG1305	Transglutaminase-like
Cthe_1183	COG0714	Associated with various cellular activities
Cthe_1186	COG0657	acetylesterase activity
Cthe_1189	COG4555	ABC transporter
Cthe_1191	COG0546	phosphoglycolate phosphatase activity
Cthe_1193	COG3328	transposase activity
Cthe_1199	COG0402	S-adenosylhomocysteine deaminase activity
Cthe_1200	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Cthe_1203	COG2719	SpoVR family
Cthe_1204	COG2718	Belongs to the UPF0229 family
Cthe_1205	COG2766	serine protein kinase
Cthe_1211	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Cthe_1215	COG0730	response to heat
Cthe_1216	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Cthe_1217	COG0542	response to heat
Cthe_1218	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Cthe_1221	COG3459	Glycosyltransferase 36 associated
Cthe_1222	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Cthe_1223	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Cthe_1224	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Cthe_1225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Cthe_1226	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Cthe_1228	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Cthe_1230	COG1555	photosystem II stabilization
Cthe_1230	COG1596	polysaccharide export
Cthe_1231	COG1686	Belongs to the peptidase S11 family
Cthe_1232	COG1022	Amp-dependent synthetase and ligase
Cthe_1234	COG0840	transmembrane signaling receptor activity
Cthe_1237	COG0495	leucyl-tRNA aminoacylation
Cthe_1238	COG0799	negative regulation of ribosome biogenesis
Cthe_1240	COG1713	HD superfamily hydrolase involved in NAD metabolism
Cthe_1241	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Cthe_1244	COG1216	Glycosyl transferase, family 2
Cthe_1245	COG0151	Belongs to the GarS family
Cthe_1246	COG0138	bifunctional purine biosynthesis protein purh
Cthe_1247	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Cthe_1248	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Cthe_1249	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Cthe_1250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Cthe_1251	COG2252	PERMEase
Cthe_1256	COG1472	Belongs to the glycosyl hydrolase 3 family
Cthe_1261	COG0205	6-phosphofructokinase activity
Cthe_1265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Cthe_1266	COG0840	transmembrane signaling receptor activity
Cthe_1267	COG2197	response regulator
Cthe_1271	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_1272	COG1191	sigma factor activity
Cthe_1273	COG2755	lipolytic protein G-D-S-L family
Cthe_1274	COG3314	Sporulation integral membrane protein YlbJ
Cthe_1276	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Cthe_1277	COG0742	ribosomal rna small subunit methyltransferase
Cthe_1278	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Cthe_1279	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Cthe_1280	COG2261	transglycosylase associated protein
Cthe_1283	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Cthe_1284	COG0297	glycogen (starch) synthase activity
Cthe_1285	COG2199	diguanylate cyclase activity
Cthe_1285	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Cthe_1286	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Cthe_1287	COG3850	Histidine kinase
Cthe_1287	COG5002	protein histidine kinase activity
Cthe_1288	COG0745	RESPONSE REGULATOR receiver
Cthe_1292	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Cthe_1295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Cthe_1297	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Cthe_1301	COG1323	Belongs to the UPF0348 family
Cthe_1302	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Cthe_1304	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Cthe_1305	COG0662	Cupin 2, conserved barrel domain protein
Cthe_1307	COG3693	PFAM glycoside hydrolase, family 10
Cthe_1308	COG0574	Belongs to the PEP-utilizing enzyme family
Cthe_1308	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Cthe_1309	COG0535	radical SAM domain protein
Cthe_1311	COG3290	protein histidine kinase activity
Cthe_1312	COG0423	glycine-tRNA ligase activity
Cthe_1313	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Cthe_1314	COG1758	RNA polymerase activity
Cthe_1315	COG0194	GDP metabolic process
Cthe_1316	COG2052	Domain of unknown function (DUF370)
Cthe_1317	COG1561	YicC-like family, N-terminal region
Cthe_1318	COG2201	protein-glutamate methylesterase activity
Cthe_1319	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Cthe_1320	COG2264	protein methyltransferase activity
Cthe_1321	COG0484	heat shock protein binding
Cthe_1322	COG0443	Heat shock 70 kDa protein
Cthe_1323	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Cthe_1324	COG1420	regulation of RNA biosynthetic process
Cthe_1325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Cthe_1326	COG0481	GTPase activity
Cthe_1331	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Cthe_1332	COG0124	histidyl-tRNA synthetase
Cthe_1341	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Cthe_1342	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Cthe_1343	COG1490	D-aminoacyl-tRNA deacylase activity
Cthe_1344	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Cthe_1345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Cthe_1346	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Cthe_1346	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Cthe_1348	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Cthe_1349	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Cthe_1350	COG0629	single-stranded DNA binding
Cthe_1352	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Cthe_1355	COG1216	Glycosyl transferase, family 2
Cthe_1363	COG0489	protein tyrosine kinase activity
Cthe_1367	COG4464	protein tyrosine phosphatase activity
Cthe_1368	COG1361	Conserved repeat domain
Cthe_1369	COG0537	adenosine 5'-monophosphoramidase activity
Cthe_1375	COG0527	aspartate kinase activity
Cthe_1376	COG0460	homoserine dehydrogenase
Cthe_1377	COG4492	Belongs to the UPF0735 family
Cthe_1378	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Cthe_1378	COG2199	diguanylate cyclase activity
Cthe_1379	COG0673	inositol 2-dehydrogenase activity
Cthe_1380	COG2201	protein-glutamate methylesterase activity
Cthe_1382	COG1752	Esterase of the alpha-beta hydrolase superfamily
Cthe_1384	COG0285	dihydrofolate synthase activity
Cthe_1385	COG0653	protein targeting
Cthe_1388	COG4496	protein, YerC YecD
Cthe_1389	COG0617	tRNA 3'-terminal CCA addition
Cthe_1390	COG2267	carboxylic ester hydrolase activity
Cthe_1391	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Cthe_1393	COG5002	protein histidine kinase activity
Cthe_1394	COG0745	RESPONSE REGULATOR receiver
Cthe_1396	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Cthe_1397	COG1442	glycosyl transferase family 8
Cthe_1398	COG4447	cellulose binding
Cthe_1402	COG1321	iron dependent repressor
Cthe_1404	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Cthe_1405	COG5337	Spore coat protein CotH
Cthe_1408	COG0745	RESPONSE REGULATOR receiver
Cthe_1409	COG5002	protein histidine kinase activity
Cthe_1410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Cthe_1411	COG0159	tryptophan synthase activity
Cthe_1412	COG0133	tryptophan synthase activity
Cthe_1415	COG1131	(ABC) transporter
Cthe_1420	COG1971	Probably functions as a manganese efflux pump
Cthe_1421	COG0616	signal peptide processing
Cthe_1422	COG1714	RDD family
Cthe_1423	COG0628	permease
Cthe_1425	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Cthe_1426	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Cthe_1433	COG1028	Short-chain dehydrogenase reductase Sdr
Cthe_1438	COG1595	DNA-templated transcription, initiation
Cthe_1446	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Cthe_1456	COG1126	abc transporter atp-binding protein
Cthe_1461	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Cthe_1461	COG0723	plastoquinol--plastocyanin reductase activity
Cthe_1465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Cthe_1470	COG1595	DNA-templated transcription, initiation
Cthe_1472	COG4124	Belongs to the glycosyl hydrolase 26 family
Cthe_1472	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Cthe_1475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Cthe_1477	COG0717	Belongs to the dCTP deaminase family
Cthe_1480	COG2409	Drug exporters of the RND superfamily
Cthe_1482	COG0561	phosphatase activity
Cthe_1485	COG0426	domain, Protein
Cthe_1485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Cthe_1486	COG0494	nUDIX hydrolase
Cthe_1488	COG0840	transmembrane signaling receptor activity
Cthe_1493	COG1695	Transcriptional regulator
Cthe_1498	COG0840	transmembrane signaling receptor activity
Cthe_1499	COG0004	ammonium transporteR
Cthe_1500	COG1132	(ABC) transporter
Cthe_1501	COG1132	(ABC) transporter
Cthe_1505	COG1361	Conserved repeat domain
Cthe_1508	COG1393	Belongs to the ArsC family
Cthe_1525	COG0577	efflux transmembrane transporter activity
Cthe_1526	COG1136	(ABC) transporter
Cthe_1527	COG2205	protein histidine kinase activity
Cthe_1528	COG0745	RESPONSE REGULATOR receiver
Cthe_1533	COG3328	transposase activity
Cthe_1536	COG1131	(ABC) transporter
Cthe_1538	COG3620	sequence-specific DNA binding
Cthe_1540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Cthe_1541	COG0154	amidase activity
Cthe_1543	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Cthe_1548	COG1024	Enoyl-CoA hydratase
Cthe_1549	COG4106	trans-aconitate 2-methyltransferase activity
Cthe_1550	COG3547	Transposase (IS116 IS110 IS902 family)
Cthe_1555	COG1464	Belongs to the NlpA lipoprotein family
Cthe_1556	COG2011	ABC-type metal ion transport system permease component
Cthe_1557	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Cthe_1559	COG0626	cystathionine gamma-synthase activity
Cthe_1560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Cthe_1568	COG0535	radical SAM domain protein
Cthe_1569	COG2873	o-acetylhomoserine
Cthe_1570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Cthe_1571	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Cthe_1573	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Cthe_1575	COG0813	purine-nucleoside phosphorylase activity
Cthe_1576	COG1744	ABC transporter substrate-binding protein PnrA-like
Cthe_1577	COG1328	CTP reductase activity
Cthe_1578	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Cthe_1579	COG3845	ABC transporter
Cthe_1580	COG4603	Belongs to the binding-protein-dependent transport system permease family
Cthe_1581	COG1079	Belongs to the binding-protein-dependent transport system permease family
Cthe_1582	COG0295	cytidine deaminase activity
Cthe_1584	COG2207	Transcriptional regulator
Cthe_1584	COG4753	response regulator
Cthe_1587	COG3842	ATPase activity
Cthe_1593	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Cthe_1599	COG5002	protein histidine kinase activity
Cthe_1600	COG0745	RESPONSE REGULATOR receiver
Cthe_1601	COG0704	Plays a role in the regulation of phosphate uptake
Cthe_1602	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Cthe_1603	COG0581	inorganic phosphate transmembrane transporter activity
Cthe_1604	COG0573	inorganic phosphate transmembrane transporter activity
Cthe_1611	COG3409	Peptidoglycan-binding domain 1 protein
Cthe_1611	COG5632	N-Acetylmuramoyl-L-alanine amidase
Cthe_1629	COG0740	serine-type endopeptidase activity
Cthe_1630	COG4695	Portal protein
Cthe_1649	COG3617	BRO family, N-terminal domain
Cthe_1650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Cthe_1650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Cthe_1658	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Cthe_1659	COG0569	domain protein
Cthe_1664	COG0789	Transcriptional regulator
Cthe_1665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Cthe_1668	COG1131	(ABC) transporter
Cthe_1679	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Cthe_1685	COG1132	(ABC) transporter
Cthe_1690	COG0535	radical SAM domain protein
Cthe_1695	COG0535	radical SAM domain protein
Cthe_1702	COG0860	N-Acetylmuramoyl-L-alanine amidase
Cthe_1720	COG0740	serine-type endopeptidase activity
Cthe_1728	COG0270	DNA (cytosine-5-)-methyltransferase activity
Cthe_1740	COG3617	BRO family, N-terminal domain
Cthe_1752	COG1120	ATPase activity
Cthe_1753	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cthe_1754	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Cthe_1757	COG0739	heme binding
Cthe_1761	COG0577	efflux transmembrane transporter activity
Cthe_1763	COG1136	(ABC) transporter
Cthe_1771	COG1592	Rubrerythrin
Cthe_1772	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Cthe_1773	COG1067	ATP-dependent peptidase activity
Cthe_1774	COG0456	acetyltransferase
Cthe_1775	COG1214	PFAM Peptidase M22, glycoprotease
Cthe_1776	COG0802	atpase or kinase
Cthe_1777	COG1228	amidohydrolase
Cthe_1782	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cthe_1783	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Cthe_1785	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Cthe_1786	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Cthe_1788	COG1215	transferase activity, transferring glycosyl groups
Cthe_1789	COG0542	response to heat
Cthe_1790	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Cthe_1791	COG3880	PFAM UvrB UvrC protein
Cthe_1795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Cthe_1796	COG0287	Prephenate dehydrogenase
Cthe_1797	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Cthe_1798	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Cthe_1799	COG0488	(ABC) transporter
Cthe_1801	COG1122	ATPase activity
Cthe_1803	COG0310	cobalt ion transport
Cthe_1804	COG0860	N-Acetylmuramoyl-L-alanine amidase
Cthe_1805	COG0745	RESPONSE REGULATOR receiver
Cthe_1808	COG3547	Transposase (IS116 IS110 IS902 family)
Cthe_1809	COG1595	DNA-templated transcription, initiation
Cthe_1812	COG0829	nickel cation binding
Cthe_1813	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Cthe_1815	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Cthe_1816	COG0804	urea catabolic process
Cthe_1817	COG0832	Belongs to the urease beta subunit family
Cthe_1818	COG0831	urea catabolic process
Cthe_1824	COG2207	Transcriptional regulator
Cthe_1824	COG4753	response regulator
Cthe_1826	COG4251	negative regulation of phosphorylation
Cthe_1839	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Cthe_1841	COG1606	tRNA processing
Cthe_1843	COG1959	2 iron, 2 sulfur cluster binding
Cthe_1844	COG1959	2 iron, 2 sulfur cluster binding
Cthe_1845	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Cthe_1846	COG5002	protein histidine kinase activity
Cthe_1847	COG0745	RESPONSE REGULATOR receiver
Cthe_1848	COG2217	Heavy metal translocating P-type atpase
Cthe_1852	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Cthe_1853	COG1278	Cold shock
Cthe_1854	COG3695	enzyme binding
Cthe_1857	COG0793	Belongs to the peptidase S41A family
Cthe_1857	COG3409	Peptidoglycan-binding domain 1 protein
Cthe_1859	COG2177	Part of the ABC transporter FtsEX involved in
Cthe_1860	COG2884	Cell division ATP-binding protein ftsE
Cthe_1861	COG3835	regulator
Cthe_1862	COG3842	ATPase activity
Cthe_1863	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Cthe_1864	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Cthe_1866	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Cthe_1867	COG0505	Belongs to the CarA family
Cthe_1868	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Cthe_1869	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Cthe_1874	COG3328	transposase activity
Cthe_1884	COG3547	Transposase (IS116 IS110 IS902 family)
Cthe_1889	COG3328	transposase activity
Cthe_1890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Cthe_1895	COG1695	Transcriptional regulator
Cthe_1896	COG1408	metallophosphoesterase
Cthe_1899	COG1876	peptidase activity
Cthe_1901	COG3328	transposase activity
Cthe_1903	COG0726	polysaccharide deacetylase
Cthe_1907	COG0300	oxidoreductase activity
Cthe_1907	COG0318	PFAM AMP-dependent synthetase and ligase
Cthe_1907	COG1028	Short-chain dehydrogenase reductase Sdr
Cthe_1907	COG3321	synthase
Cthe_1907	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Cthe_1915	COG5002	protein histidine kinase activity
Cthe_1916	COG0745	RESPONSE REGULATOR receiver
Cthe_1917	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Cthe_1918	COG1982	Orn Lys Arg decarboxylase major
Cthe_1919	COG1285	pathogenesis
Cthe_1921	COG1695	Transcriptional regulator
Cthe_1923	COG0504	CTP synthase activity
Cthe_1930	COG3409	Peptidoglycan-binding domain 1 protein
Cthe_1930	COG0793	Belongs to the peptidase S41A family
Cthe_1933	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Cthe_1935	COG0018	arginyl-trna synthetase
Cthe_1937	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Cthe_1938	COG1181	Belongs to the D-alanine--D-alanine ligase family
Cthe_1939	COG2239	Acts as a magnesium transporter
Cthe_1943	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Cthe_1944	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Cthe_1945	COG0492	ferredoxin-NADP+ reductase activity
Cthe_1947	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Cthe_1948	COG0785	Cytochrome C biogenesis protein
Cthe_1955	COG2183	response to ionizing radiation
Cthe_1959	COG2226	methyltransferase
Cthe_1961	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Cthe_1963	COG2382	esterase
Cthe_1963	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_1963	COG3693	PFAM glycoside hydrolase, family 10
Cthe_1964	COG3634	alkyl hydroperoxide reductase activity
Cthe_1965	COG0450	alkyl hydroperoxide reductase
Cthe_1967	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Cthe_1991	COG3328	transposase activity
Cthe_2004	COG2390	Transcriptional regulator
Cthe_2004	COG4584	PFAM Integrase catalytic
Cthe_2017	COG3328	transposase activity
Cthe_2034	COG0457	Tetratricopeptide repeat
Cthe_2034	COG0515	serine threonine protein kinase
Cthe_2039	COG1074	ATP-dependent DNA helicase activity
Cthe_2040	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
Cthe_2058	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Cthe_2060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Cthe_2062	COG0697	spore germination
Cthe_2065	COG0215	cysteine-tRNA ligase activity
Cthe_2066	COG1045	serine acetyltransferase
Cthe_2073	COG1473	amidohydrolase
Cthe_2074	COG2155	Conserved Protein
Cthe_2075	COG0217	transcriptional regulatory protein
Cthe_2076	COG5002	protein histidine kinase activity
Cthe_2078	COG1739	Uncharacterized protein family UPF0029
Cthe_2079	COG0681	Belongs to the peptidase S26 family
Cthe_2080	COG0494	nUDIX hydrolase
Cthe_2081	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Cthe_2083	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Cthe_2085	COG0756	dUTP diphosphatase activity
Cthe_2086	COG0826	peptidase U32
Cthe_2087	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Cthe_2089	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_2092	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Cthe_2093	COG3583	domain protein
Cthe_2093	COG3584	3D domain protein
Cthe_2095	COG0084	hydrolase, TatD family'
Cthe_2096	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Cthe_2096	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Cthe_2098	COG0700	Nucleoside recognition
Cthe_2099	COG2715	membrane protein required for spore maturation
Cthe_2100	COG2002	toxin-antitoxin pair type II binding
Cthe_2101	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Cthe_2102	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Cthe_2104	COG1774	PSP1 C-terminal conserved region
Cthe_2105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Cthe_2106	COG1728	Protein conserved in bacteria
Cthe_2108	COG1982	Orn Lys Arg decarboxylase major
Cthe_2110	COG1136	(ABC) transporter
Cthe_2113	COG5002	protein histidine kinase activity
Cthe_2116	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Cthe_2117	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Cthe_2119	COG3693	PFAM glycoside hydrolase, family 10
Cthe_2120	COG1191	sigma factor activity
Cthe_2125	COG0395	ABC-type sugar transport system, permease component
Cthe_2126	COG1175	transmembrane transport
Cthe_2127	COG0714	Associated with various cellular activities
Cthe_2138	COG3940	Belongs to the glycosyl hydrolase 43 family
Cthe_2139	COG3940	Belongs to the glycosyl hydrolase 43 family
Cthe_2141	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Cthe_2142	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Cthe_2143	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Cthe_2144	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Cthe_2155	COG1361	Conserved repeat domain
Cthe_2162	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Cthe_2164	COG1773	rubredoxin
Cthe_2169	COG1408	metallophosphoesterase
Cthe_2172	COG0254	rRNA binding
Cthe_2174	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Cthe_2180	COG0038	chloride channel
Cthe_2181	COG0037	tRNA processing
Cthe_2183	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Cthe_2184	COG1295	ribonuclease BN
Cthe_2185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Cthe_2186	COG0629	single-stranded DNA binding
Cthe_2187	COG0360	Binds together with S18 to 16S ribosomal RNA
Cthe_2190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Cthe_2191	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Cthe_2193	COG3693	PFAM glycoside hydrolase, family 10
Cthe_2193	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_2193	COG2382	esterase
Cthe_2194	COG3693	PFAM glycoside hydrolase, family 10
Cthe_2194	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_2194	COG2382	esterase
Cthe_2195	COG2382	esterase
Cthe_2195	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_2195	COG3693	PFAM glycoside hydrolase, family 10
Cthe_2196	COG3507	Belongs to the glycosyl hydrolase 43 family
Cthe_2198	COG2390	Transcriptional regulator
Cthe_2198	COG4584	PFAM Integrase catalytic
Cthe_2201	COG3328	transposase activity
Cthe_2203	COG0302	gtp cyclohydrolase
Cthe_2204	COG1181	Belongs to the D-alanine--D-alanine ligase family
Cthe_2204	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Cthe_2205	COG4242	Belongs to the peptidase S51 family
Cthe_2207	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Cthe_2208	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Cthe_2209	COG0473	3-isopropylmalate dehydrogenase activity
Cthe_2210	COG0066	3-isopropylmalate dehydratase activity
Cthe_2211	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Cthe_2212	COG2207	Transcriptional regulator
Cthe_2213	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Cthe_2217	COG1516	flagellar protein fliS
Cthe_2218	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Cthe_2220	COG1088	dTDP-glucose 4,6-dehydratase activity
Cthe_2221	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Cthe_2224	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Cthe_2227	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Cthe_2229	COG2089	acid synthase
Cthe_2230	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
Cthe_2231	COG2226	methyltransferase
Cthe_2232	COG1086	Polysaccharide biosynthesis protein
Cthe_2236	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Cthe_2237	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Cthe_2239	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Cthe_2240	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Cthe_2242	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Cthe_2243	COG4786	Flagellar basal body rod
Cthe_2243	COG1256	bacterial-type flagellum assembly
Cthe_2248	COG1040	competence protein
Cthe_2249	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Cthe_2251	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Cthe_2253	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Cthe_2254	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Cthe_2255	COG0037	tRNA processing
Cthe_2256	COG0305	Participates in initiation and elongation during chromosome replication
Cthe_2257	COG0359	binds to the 23S rRNA
Cthe_2258	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Cthe_2260	COG0077	Prephenate dehydratase
Cthe_2260	COG1605	Chorismate mutase
Cthe_2262	COG1269	ATP hydrolysis coupled proton transport
Cthe_2263	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Cthe_2264	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Cthe_2267	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Cthe_2268	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Cthe_2269	COG1394	ATPase activity, coupled to movement of substances
Cthe_2270	COG0488	(ABC) transporter
Cthe_2276	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Cthe_2279	COG0765	amino acid transport
Cthe_2281	COG2201	protein-glutamate methylesterase activity
Cthe_2282	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Cthe_2284	COG2198	Histidine kinase
Cthe_2284	COG0643	Histidine kinase
Cthe_2285	COG0835	chemotaxis
Cthe_2286	COG0582	viral genome integration into host DNA
Cthe_2287	COG2207	Transcriptional regulator
Cthe_2287	COG3708	Transcriptional regulator
Cthe_2290	COG1131	(ABC) transporter
Cthe_2294	COG2390	Transcriptional regulator
Cthe_2294	COG4584	PFAM Integrase catalytic
Cthe_2296	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Cthe_2297	COG1518	maintenance of DNA repeat elements
Cthe_2305	COG1968	undecaprenyl-diphosphatase activity
Cthe_2306	COG0534	Mate efflux family protein
Cthe_2326	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Cthe_2327	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Cthe_2328	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Cthe_2332	COG5002	protein histidine kinase activity
Cthe_2333	COG0745	RESPONSE REGULATOR receiver
Cthe_2336	COG0438	transferase activity, transferring glycosyl groups
Cthe_2338	COG0438	transferase activity, transferring glycosyl groups
Cthe_2344	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Cthe_2345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Cthe_2348	COG1361	Conserved repeat domain
Cthe_2350	COG3773	Cell wall hydrolase
Cthe_2352	COG0517	IMP dehydrogenase activity
Cthe_2355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Cthe_2356	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Cthe_2359	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Cthe_2360	COG4733	cellulase activity
Cthe_2360	COG4447	cellulose binding
Cthe_2361	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Cthe_2362	COG1475	DNA binding
Cthe_2363	COG0357	Ribosomal RNA small subunit methyltransferase G
Cthe_2364	COG0445	tRNA wobble uridine modification
Cthe_2365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Cthe_2366	COG1847	R3H domain protein
Cthe_2367	COG0706	membrane insertase activity
Cthe_2368	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Cthe_2370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Cthe_2371	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Cthe_2372	COG0592	DNA-directed DNA polymerase activity
Cthe_2374	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Cthe_2376	COG0187	DNA topoisomerase II activity
Cthe_2377	COG1192	Involved in chromosome partitioning
Cthe_2378	COG1475	DNA binding
Cthe_2381	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Cthe_2382	COG2814	Major facilitator Superfamily
Cthe_2384	COG2373	Large extracellular alpha-helical protein
Cthe_2386	COG2720	vancomycin resistance protein
Cthe_2390	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Cthe_2392	COG0674	pyruvate-flavodoxin oxidoreductase activity
Cthe_2393	COG1013	pyruvate-flavodoxin oxidoreductase activity
Cthe_2399	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Cthe_2403	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Cthe_2404	COG1802	Transcriptional regulator
Cthe_2405	COG2608	mercury ion transmembrane transporter activity
Cthe_2407	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Cthe_2412	COG4717	serine-type aminopeptidase activity
Cthe_2413	COG0791	NLP P60 protein
Cthe_2414	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Cthe_2416	COG2959	enzyme of heme biosynthesis
Cthe_2420	COG1078	dGTPase activity
Cthe_2427	COG3872	metal-dependent enzyme
Cthe_2428	COG2890	protein-(glutamine-N5) methyltransferase activity
Cthe_2430	COG4656	Part of a membrane complex involved in electron transport
Cthe_2431	COG4658	electron transport chain
Cthe_2432	COG4659	FMN binding
Cthe_2433	COG4660	Part of a membrane complex involved in electron transport
Cthe_2434	COG4657	Part of a membrane complex involved in electron transport
Cthe_2435	COG2878	Part of a membrane complex involved in electron transport
Cthe_2441	COG1349	DNA-binding transcription factor activity
Cthe_2442	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Cthe_2443	COG3959	Transketolase, thiamine diphosphate binding domain
Cthe_2444	COG3958	Transketolase
Cthe_2445	COG1063	alcohol dehydrogenase
Cthe_2446	COG1879	ABC-type sugar transport system periplasmic component
Cthe_2447	COG1129	ABC transporter
Cthe_2449	COG0406	alpha-ribazole phosphatase activity
Cthe_2451	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Cthe_2452	COG1164	Oligoendopeptidase f
Cthe_2454	COG3693	PFAM glycoside hydrolase, family 10
Cthe_2455	COG0582	viral genome integration into host DNA
Cthe_2460	COG1396	sequence-specific DNA binding
Cthe_2462	COG3617	BRO family, N-terminal domain
Cthe_2467	COG1484	DNA-dependent DNA replication
Cthe_2474	COG1783	phage Terminase large subunit
Cthe_2484	COG3547	Transposase (IS116 IS110 IS902 family)
Cthe_2489	COG2823	Periplasmic or secreted lipoprotein
Cthe_2489	COG1652	LysM domain
Cthe_2490	COG4193	domain, Protein
Cthe_2492	COG3299	homolog of phage Mu protein gp47
Cthe_2498	COG3409	Peptidoglycan-binding domain 1 protein
Cthe_2498	COG5632	N-Acetylmuramoyl-L-alanine amidase
Cthe_2502	COG0590	tRNA wobble adenosine to inosine editing
Cthe_2503	COG0662	Cupin 2, conserved barrel domain protein
Cthe_2504	COG3584	3D domain protein
Cthe_2505	COG1609	Transcriptional regulator
Cthe_2506	COG4447	cellulose binding
Cthe_2506	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_2511	COG0668	transmembrane transport
Cthe_2513	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Cthe_2515	COG0590	tRNA wobble adenosine to inosine editing
Cthe_2516	COG0028	Belongs to the TPP enzyme family
Cthe_2517	COG0440	acetolactate synthase activity
Cthe_2518	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Cthe_2519	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Cthe_2521	COG1191	sigma factor activity
Cthe_2524	COG1959	2 iron, 2 sulfur cluster binding
Cthe_2525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Cthe_2527	COG0181	hydroxymethylbilane synthase activity
Cthe_2529	COG0113	porphobilinogen synthase activity
Cthe_2530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Cthe_2531	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Cthe_2532	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Cthe_2533	COG4208	sulfate ABC transporter
Cthe_2535	COG0175	sulfate reduction
Cthe_2536	COG0175	sulfate reduction
Cthe_2539	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Cthe_2544	COG1595	DNA-templated transcription, initiation
Cthe_2548	COG3534	alpha-L-arabinofuranosidase
Cthe_2549	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_2551	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Cthe_2553	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Cthe_2556	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Cthe_2557	COG1216	Glycosyl transferase, family 2
Cthe_2558	COG1088	dTDP-glucose 4,6-dehydratase activity
Cthe_2560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Cthe_2566	COG1032	radical SAM domain protein
Cthe_2573	COG1116	anion transmembrane transporter activity
Cthe_2574	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Cthe_2575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Cthe_2577	COG2954	triphosphatase activity
Cthe_2581	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Cthe_2582	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Cthe_2583	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Cthe_2585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Cthe_2585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Cthe_2588	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Cthe_2590	COG3693	PFAM glycoside hydrolase, family 10
Cthe_2593	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Cthe_2594	COG0428	transporter
Cthe_2595	COG0009	L-threonylcarbamoyladenylate synthase
Cthe_2597	COG0698	ribose 5-phosphate isomerase
Cthe_2598	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Cthe_2599	COG2131	deaminase
Cthe_2600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Cthe_2601	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Cthe_2602	COG0356	it plays a direct role in the translocation of protons across the membrane
Cthe_2603	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Cthe_2604	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Cthe_2605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Cthe_2606	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Cthe_2607	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Cthe_2608	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Cthe_2609	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Cthe_2613	COG3266	domain, Protein
Cthe_2613	COG2911	Protein conserved in bacteria
Cthe_2613	COG1361	Conserved repeat domain
Cthe_2615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Cthe_2616	COG2385	sporulation resulting in formation of a cellular spore
Cthe_2618	COG1609	Transcriptional regulator
Cthe_2620	COG4786	Flagellar basal body rod
Cthe_2625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Cthe_2626	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Cthe_2627	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Cthe_2628	COG2088	sporulation resulting in formation of a cellular spore
Cthe_2629	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Cthe_2631	COG0193	aminoacyl-tRNA hydrolase activity
Cthe_2632	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Cthe_2633	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Cthe_2634	COG1917	Cupin 2, conserved barrel domain protein
Cthe_2634	COG2207	Transcriptional regulator
Cthe_2635	COG0259	pyridoxamine-phosphate oxidase activity
Cthe_2636	COG0728	peptidoglycan biosynthetic process
Cthe_2640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Cthe_2641	COG2089	acid synthase
Cthe_2643	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Cthe_2644	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Cthe_2645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Cthe_2647	COG1181	Belongs to the D-alanine--D-alanine ligase family
Cthe_2648	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Cthe_2654	COG4464	protein tyrosine phosphatase activity
Cthe_2655	COG2002	toxin-antitoxin pair type II binding
Cthe_2656	COG3956	TIGRFAM MazG family protein
Cthe_2658	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Cthe_2662	COG1098	S1 RNA binding domain
Cthe_2663	COG0840	transmembrane signaling receptor activity
Cthe_2664	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Cthe_2671	COG3328	transposase activity
Cthe_2672	COG3328	transposase activity
Cthe_2677	COG4191	Histidine kinase
Cthe_2680	COG0793	Belongs to the peptidase S41A family
Cthe_2685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Cthe_2686	COG0849	cell division
Cthe_2687	COG1607	acyl-coa hydrolase
Cthe_2688	COG2244	polysaccharide biosynthetic process
Cthe_2689	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Cthe_2691	COG0110	maltose O-acetyltransferase activity
Cthe_2696	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Cthe_2696	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Cthe_2697	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Cthe_2698	COG0864	Transcriptional regulator
Cthe_2699	COG2337	Toxic component of a toxin-antitoxin (TA) module
Cthe_2702	COG0438	transferase activity, transferring glycosyl groups
Cthe_2703	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Cthe_2704	COG3959	Transketolase, thiamine diphosphate binding domain
Cthe_2705	COG3958	Transketolase
Cthe_2706	COG1131	(ABC) transporter
Cthe_2710	COG3949	Membrane
Cthe_2713	COG0129	dihydroxy-acid dehydratase activity
Cthe_2714	COG0028	Belongs to the TPP enzyme family
Cthe_2719	COG0250	Participates in transcription elongation, termination and antitermination
Cthe_2720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Cthe_2721	COG0081	regulation of translation
Cthe_2722	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Cthe_2724	COG0085	RNA polymerase activity
Cthe_2725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Cthe_2726	COG1358	cellular component organization or biogenesis
Cthe_2727	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Cthe_2728	COG0049	tRNA binding
Cthe_2729	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Cthe_2730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Cthe_2734	COG2720	vancomycin resistance protein
Cthe_2736	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Cthe_2737	COG0322	excinuclease ABC activity
Cthe_2739	COG0544	peptidyl-prolyl cis-trans isomerase activity
Cthe_2740	COG0740	serine-type endopeptidase activity
Cthe_2741	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Cthe_2742	COG1067	ATP-dependent peptidase activity
Cthe_2742	COG0470	DNA polymerase III
Cthe_2743	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Cthe_2744	COG0741	lytic transglycosylase activity
Cthe_2747	COG0613	PHP domain protein
Cthe_2748	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Cthe_2752	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Cthe_2757	COG3263	regulation of cellular component size
Cthe_2759	COG3708	Transcriptional regulator
Cthe_2759	COG2207	Transcriptional regulator
Cthe_2760	COG4447	cellulose binding
Cthe_2760	COG4733	cellulase activity
Cthe_2761	COG5297	Belongs to the glycosyl hydrolase family 6
Cthe_2768	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Cthe_2769	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Cthe_2770	COG3547	Transposase (IS116 IS110 IS902 family)
Cthe_2775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Cthe_2782	COG2911	Protein conserved in bacteria
Cthe_2782	COG1361	Conserved repeat domain
Cthe_2782	COG3266	domain, Protein
Cthe_2784	COG5012	cobalamin binding
Cthe_2785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Cthe_2790	COG1116	anion transmembrane transporter activity
Cthe_2791	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Cthe_2792	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Cthe_2794	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Cthe_2796	COG0674	pyruvate-flavodoxin oxidoreductase activity
Cthe_2797	COG1013	pyruvate-flavodoxin oxidoreductase activity
Cthe_2798	COG0251	oxidation-reduction process
Cthe_2799	COG0626	cystathionine gamma-synthase activity
Cthe_2800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Cthe_2801	COG1151	hydroxylamine reductase activity
Cthe_2803	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Cthe_2804	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Cthe_2807	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Cthe_2808	COG1609	Transcriptional regulator
Cthe_2811	COG4124	Belongs to the glycosyl hydrolase 26 family
Cthe_2812	COG4447	cellulose binding
Cthe_2812	COG4733	cellulase activity
Cthe_2814	COG2205	protein histidine kinase activity
Cthe_2816	COG3328	transposase activity
Cthe_2817	COG0835	chemotaxis
Cthe_2818	COG0643	Histidine kinase
Cthe_2818	COG2198	Histidine kinase
Cthe_2818	COG0784	Response regulator, receiver
Cthe_2820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Cthe_2821	COG2201	protein-glutamate methylesterase activity
Cthe_2829	COG3328	transposase activity
Cthe_2831	COG4584	PFAM Integrase catalytic
Cthe_2831	COG2390	Transcriptional regulator
Cthe_2832	COG3328	transposase activity
Cthe_2858	COG3328	transposase activity
Cthe_2870	COG1253	flavin adenine dinucleotide binding
Cthe_2872	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Cthe_2874	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Cthe_2880	COG0124	histidyl-tRNA synthetase
Cthe_2881	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Cthe_2882	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Cthe_2883	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Cthe_2884	COG0131	Imidazoleglycerol-phosphate dehydratase
Cthe_2885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Cthe_2886	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Cthe_2887	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Cthe_2888	COG0107	imidazoleglycerol-phosphate synthase activity
Cthe_2891	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Cthe_2892	COG0459	protein refolding
Cthe_2895	COG3858	chitin binding
Cthe_2897	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Cthe_2898	COG1366	Belongs to the anti-sigma-factor antagonist family
Cthe_2899	COG2172	sigma factor antagonist activity
Cthe_2900	COG1191	sigma factor activity
Cthe_2902	COG0051	transcription antitermination factor activity, RNA binding
Cthe_2903	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Cthe_2904	COG0088	Forms part of the polypeptide exit tunnel
Cthe_2905	COG0089	rRNA binding
Cthe_2906	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Cthe_2907	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Cthe_2908	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Cthe_2909	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Cthe_2910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Cthe_2911	COG0255	Belongs to the universal ribosomal protein uL29 family
Cthe_2912	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Cthe_2913	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Cthe_2914	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Cthe_2915	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Cthe_2916	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Cthe_2917	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Cthe_2918	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Cthe_2919	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Cthe_2920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Cthe_2921	COG1841	ribosomal large subunit assembly
Cthe_2922	COG0200	Binds to the 23S rRNA
Cthe_2923	COG0201	protein transport
Cthe_2924	COG0563	adenylate kinase activity
Cthe_2927	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Cthe_2928	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Cthe_2929	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Cthe_2930	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Cthe_2931	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Cthe_2932	COG0202	RNA polymerase activity
Cthe_2933	COG0203	ribosomal protein L17
Cthe_2934	COG1122	ATPase activity
Cthe_2935	COG2813	Specifically methylates the guanine in position
Cthe_2936	COG1122	ATPase activity
Cthe_2937	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Cthe_2938	COG1940	carbohydrate kinase activity
Cthe_2939	COG0101	tRNA pseudouridine synthase activity
Cthe_2940	COG1329	Transcriptional regulator
Cthe_2941	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Cthe_2942	COG4555	ABC transporter
Cthe_2943	COG1668	transmembrane transport
Cthe_2944	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Cthe_2944	COG4191	Histidine kinase
Cthe_2945	COG3290	protein histidine kinase activity
Cthe_2946	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Cthe_2947	COG0442	prolyl-tRNA aminoacylation
Cthe_2948	COG2340	Cysteine-rich secretory protein family
Cthe_2949	COG2273	Hydrolase Family 16
Cthe_2950	COG3250	beta-galactosidase activity
Cthe_2958	COG3328	transposase activity
Cthe_2961	COG4166	transmembrane transport
Cthe_2962	COG4608	Belongs to the ABC transporter superfamily
Cthe_2963	COG0444	Belongs to the ABC transporter superfamily
Cthe_2964	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Cthe_2965	COG0601	transmembrane transport
Cthe_2969	COG1725	Transcriptional regulator
Cthe_2970	COG1131	(ABC) transporter
Cthe_2973	COG1489	DNA binding
Cthe_2974	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Cthe_2975	COG1191	sigma factor activity
Cthe_2983	COG0840	transmembrane signaling receptor activity
Cthe_2990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Cthe_2996	COG0693	protein deglycase activity
Cthe_2998	COG1132	(ABC) transporter
Cthe_3000	COG0306	phosphate transporter
Cthe_3005	COG1388	LysM domain
Cthe_3006	COG1376	ErfK ybiS ycfS ynhG family protein
Cthe_3012	COG5520	Belongs to the glycosyl hydrolase 30 family
Cthe_3014	COG0409	Hydrogenase expression formation protein
Cthe_3016	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Cthe_3020	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Cthe_3020	COG3261	NADH dehydrogenase
Cthe_3022	COG3260	NADH ubiquinone oxidoreductase 20
Cthe_3024	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Cthe_3024	COG2111	Na H antiporter
Cthe_3026	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Cthe_3027	COG0372	Belongs to the citrate synthase family
Cthe_3028	COG0076	glutamate decarboxylase activity
Cthe_3029	COG0835	chemotaxis
Cthe_3030	COG0840	transmembrane signaling receptor activity
Cthe_3035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Cthe_3036	COG0840	transmembrane signaling receptor activity
Cthe_3043	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Cthe_3047	COG0768	penicillin binding
Cthe_3048	COG2003	Belongs to the UPF0758 family
Cthe_3051	COG3328	transposase activity
Cthe_3059	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
Cthe_3063	COG3458	cephalosporin-C deacetylase activity
Cthe_3066	COG1131	(ABC) transporter
Cthe_3068	COG5002	protein histidine kinase activity
Cthe_3069	COG0745	RESPONSE REGULATOR receiver
Cthe_3073	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Cthe_3074	COG0561	phosphatase activity
Cthe_3075	COG2304	oxidoreductase activity
Cthe_3077	COG2911	Protein conserved in bacteria
Cthe_3078	COG1361	Conserved repeat domain
Cthe_3078	COG2911	Protein conserved in bacteria
Cthe_3078	COG3266	domain, Protein
Cthe_3079	COG1361	Conserved repeat domain
Cthe_3080	COG1361	Conserved repeat domain
Cthe_3084	COG0116	Belongs to the methyltransferase superfamily
Cthe_3086	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Cthe_3090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Cthe_3093	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Cthe_3094	COG0463	Glycosyl transferase, family 2
Cthe_3097	COG0463	Glycosyl transferase, family 2
Cthe_3099	COG1216	Glycosyl transferase, family 2
Cthe_3100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Cthe_3101	COG0436	Aminotransferase
Cthe_3102	COG1316	TRANSCRIPTIONal
Cthe_3105	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Cthe_3106	COG0720	synthase
Cthe_3107	COG0602	queuosine metabolic process
Cthe_3108	COG1573	uracil-dna glycosylase
Cthe_3109	COG1573	uracil-dna glycosylase
Cthe_3110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Cthe_3112	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Cthe_3113	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Cthe_3116	COG1482	cell wall glycoprotein biosynthetic process
Cthe_3118	COG2703	oxygen carrier activity
Cthe_3119	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Cthe_3119	COG1773	rubredoxin
Cthe_3122	COG1361	Conserved repeat domain
Cthe_3124	COG0318	PFAM AMP-dependent synthetase and ligase
Cthe_3126	COG1056	cytidyltransferase-related domain
Cthe_3126	COG1051	belongs to the nudix hydrolase family
Cthe_3129	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Cthe_3132	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Cthe_3133	COG2267	carboxylic ester hydrolase activity
Cthe_3141	COG3401	FG-GAP repeat protein
Cthe_3141	COG2755	lipolytic protein G-D-S-L family
Cthe_3144	COG3708	Transcriptional regulator
Cthe_3144	COG2207	Transcriptional regulator
Cthe_3147	COG1132	(ABC) transporter
Cthe_3148	COG1132	(ABC) transporter
Cthe_3149	COG2195	Cleaves the N-terminal amino acid of tripeptides
Cthe_3152	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Cthe_3156	COG0840	transmembrane signaling receptor activity
Cthe_3157	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Cthe_3158	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Cthe_3159	COG1802	Transcriptional regulator
Cthe_3160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Cthe_3160	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Cthe_3161	COG1187	pseudouridine synthase activity
Cthe_3166	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Cthe_3167	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Cthe_3168	COG1597	lipid kinase activity
Cthe_3170	COG1136	(ABC) transporter
Cthe_3172	COG1136	(ABC) transporter
Cthe_3172	COG0577	efflux transmembrane transporter activity
Cthe_3175	COG2323	membrane
Cthe_3179	COG1686	Belongs to the peptidase S11 family
Cthe_3183	COG0569	domain protein
Cthe_3190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Cthe_3199	COG0628	permease
Cthe_3200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Cthe_3207	COG3328	transposase activity
Cthe_3216	COG3328	transposase activity